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Results 601 - 650 of 2827
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Bigham Abigail W - - 2013
OBJECTIVES: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean Altiplano and the Tibetan Plateau for millennia and exhibit unique circulatory, respiratory, and hematological adaptations to life at high ...
Sjölander Annica - - 2013
Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimer's disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal ...
Thorstensen Anders - - 2013
We aimed to compare three-dimensional (3D) and two-dimensional (2D) echocardiography in the evaluation of patients with recent myocardial infarction (MI), using late-enhancement magnetic resonance imaging (LE-MRI) as a reference method. Echocardiography and LE-MRI were performed approximately 1 month after first-time MI in 58 patients. Echocardiography was also performed on 35 healthy ...
Al-Nawafleh Ahmed - - 2013
There is a dearth of research exploring the development of postdoctoral nursing research careers in non-Western contexts. This paper reports on a qualitative study of Jordanian graduates of UK PhD programs. Interviews were held with 16 graduates who worked in the nursing faculty of seven different universities in Jordan. Participants ...
Wollburg Eileen - - 2013
OBJECTIVE: Anorexia nervosa (AN) is a debilitating and often chronic and treatment-resistant disorder. Despite decades of theoretical progress and research, many questions remain with regard to the psychological mechanisms explaining why and how some AN patients respond to treatment whereas others do not. Based on the premise that the broader, ...
Wang Jinguo - - 2013
A novel mesoporous yolk-shell SnS(2)-TiO(2) visible photocatalyst (ST-is) was synthesized by in situ doping TiO(2) with SnO(2) through solvothermal alcoholysis, followed by sulfurization under hydrothermal conditions. The ST-is displayed higher activity in photocatalytic reduction of Cr(vi) owing to the strong photosensitizing effect of SnS(2) in uniform nanoparticles and the enhanced ...
Liu Xin - - 2013
Rice-shaped Ti(3+) self-doped TiO(2-x) nanoparticles were synthesized by mild hydrothermal treatment of TiH(2) in H(2)O(2) aqueous solution. The structure, crystallinity, morphology, and other properties of the as-prepared samples were characterized by X-ray diffraction, transmission electron microscopy, high-resolution transmission electron microcopy and X-ray photoelectron spectra. Electron paramagnetic resonance spectra confirm the ...
Fan Wei - - 2013
Abstract The results of several studies about the effectiveness of recombinant luteinizing hormone (rLH) supplementation in poor responder in vitro fertilization (IVF) patients were conflicting. To evaluate the current available data regarding the efficacy of rLH supplementation in poor responders, a meta-analysis was performed. A systemic search was performed without ...
Manchaiah Vinaya Kc - - 2013
ABSTRACT: BACKGROUND: Hearing impairment is one of the most frequent chronic conditions. Persons with a hearing impairment (PHI) have various experiences during their 'journey' through hearing loss. In our previous studies we have developed a 'patient journey' model of PHI and their communication partners (CPs). We suggest this model could ...
Ip Alex Y K - - 2013
The objective of this study was to examine the effects of 6 days of emersion on nitrogen metabolism and excretion in the Chinese soft-shelled turtle, Pelodiscus sinensis. Despite having a soft shell with a cutaneous surface which is known to be water permeable, P. sinensis lost only ~2% of body ...
Szabó Péter M - - 2013
MicroRNAs (miRNAs) are small (16-24 nucleotides) noncoding RNAs that negatively regulate gene expression. Growing evidence demonstrates that miRNAs participate in the regulation of numerous physiological and pathological processes. The clinical utility of the cell-type-specific miRNA expression profile (miRomics) has been directly demonstrated in molecular classification of tumor samples and in ...
Kota Daniel Jiro - - 2013
Genetic and immunological screening for type 1 diabetes has led to the possibility of preventing disease in susceptible individuals. Here, we show that human Mesenchymal Stem/Stromal Cells (hMSCs) and TNF-α-stimulated gene 6 (TSG-6), a protein produced by hMSCs in response to signals from injured tissues, delayed the onset of spontaneous ...
Foschini Maria P - - 2013
Metastases to cervical lymph nodes (LNs) are an important independent adverse indicator in the prognosis of oral squamous cell carcinoma (OSCC). An accurate evaluation of molecular patterns favoring the metastatic process can be helpful in predicting cases of OSCC with elevated probability of early or late metastases and, moreover, in ...
Sarris J - - 2013
Presently, little is known about a number issues concerning kava (Piper methysticum), including (i) whether kava has any withdrawal or addictive effects; (ii) if genetic polymorphisms of the cytochrome (CYP) P450 2D6 liver enzyme moderates any potential adverse effects; and (iii) if medicinal application of kava has any negative or ...
Bayramoglu Aysegul - - 2013
Abstract In the present study, we describe the effects of lycopene on the symptoms of streptozotocin (STZ)-induced diabetes in rats. Lycopene at the dose of 2.5 mg/kg body weight (bw) per day was orally administered to STZ-induced diabetic rats for a period of 7 days after onset of diabetes. At the ...
Wallace Lorraine S - - 2013
This study examined adults' self-reported understanding and formatting preferences of medical statistics, confidence in self-care and ability to obtain health advice or information, and perceptions of patient-health-care provider communication measured through dual survey modes (random digital dial and mail). Even while controlling for sociodemographic characteristics, significant differences in regard to ...
Cha Yong Sung - - 2013
BACKGROUND AND PURPOSE: By contrast with neurologic injury, myocardial injury associated with carbon monoxide (CO) poisoning has not been well investigated. Therefore, this study assessed features and predictors of myocardial injury in CO poisoned patients. SUBJECTS AND METHODS: 250 CO poisoning cases that were diagnosed and treated by the emergency ...
Nam Hyeyoung - - 2013
Background. The liver, pancreas, and heart are particularly susceptible to iron-related disorders. These tissues take up plasma iron from transferrin or non-transferrin-bound iron, which appears during iron overload. Here, we assessed the effect of iron status on the levels of the transmembrane transporters, ZRT/IRT-like protein 14 and divalent metal-ion transporter-1, ...
Lichtenstern Christoph - - 2013
Liver transplant recipients are at a significant risk for invasive fungal infections (IFI). This retrospective study evaluated the impact of the pretransplant model for end stage liver disease (MELD) on the incidence of posttransplant IFI in a single centre. From 2004 to 2008, 385 liver transplantations were included, from which ...
Morotti Elena - - 2013
INTRODUCTION: Increased body mass index is associated with a higher prevalence of metabolic diseases, depression, and sexual dysfunction. In obese patients, the perception of an altered body image may influence health and psychologically related behaviors. Furthermore, there is a significant positive relationship between sexual function, sexual satisfaction, and all body ...
Lind Eric M - - 2013
Plant growth can be limited by resource acquisition and defence against consumers, leading to contrasting trade-off possibilities. The competition-defence hypothesis posits a trade-off between competitive ability and defence against enemies (e.g. herbivores and pathogens). The growth-defence hypothesis suggests that strong competitors for nutrients are also defended against enemies, at a ...
De Jong Audrey - - 2013
RATIONALE: Difficult intubation in ICU is a challenging issue. OBJECTIVES: To develop and validate a simplified score for identifying patients with difficult intubation in ICU and to report related complications. METHODS: Data collected in a prospective multicenter-study from 1000 consecutive intubation from 42 ICU were used to develop a simplified ...
von Knobelsdorff-Brenkenhoff Florian - - 2013
PURPOSE: To establish a suitable setup for combining isometric handgrip exercise with cardiovascular magnetic resonance (CMR) imaging and to assess cardiovascular effects. MATERIALS AND METHODS: Fifty-three healthy volunteers (31 males, mean age 45 ± 17 years) underwent handgrip exercise in a 3T scanner using a prototype handgrip system and a ...
Groeneveldt Lara - - 2013
ABSTRACT: BACKGROUND: Exercise programmes are beneficial for cancer patients however evidence is limited in patients with multiple myeloma (MM), a cancer that is characterised by osteolytic bone disease, giving rise to high levels of bone morbidity including fractures and bone pain. METHODS: We conducted a single arm phase 2 study ...
Clark-Price Stuart C - - 2013
OBJECTIVE: To compare a towel under, a warm water pad under or a forced warm air blanket over dogs as techniques to reduce heat loss during a standardized anesthetic. STUDY DESIGN: Prospective, randomized, crossover study. ANIMALS: Eight, healthy, mixed breed dogs weighing 16.3-19.6 kg. METHODS: Dogs were anesthetized four times for ...
Bago-Rozankovic Petra - - 2013
The papillary carcinoma of the thyroid gland is the most common type of tumor of the thyroid gland with good prognosis and low incidence of distant metastasis. The brain metastases of thyroid gland carcinoma are extremely rare. We report a patient with multiple cystic brain lesions and satisfying criteria for ...
Lima Steven L - - 2013
Many aspects of animal behaviour are affected by real-time changes in the risk of predation. This conclusion holds for virtually all taxa and ecological systems studied, but does it hold for bats? Bats are poorly represented in the literature on anti-predator behaviour, which may reflect a lack of nocturnal predators ...
Courand Pierre-Yves - - 2013
BACKGROUND: Late presentation of abnormal origin of coronary artery from the pulmonary artery (ACAPA) is uncommon compared with early presentation, which usually induces extended myocardial necrosis and severe heart failure. The late presentation is characterized by abundant development of intercoronary collaterals resulting in mild and rare symptoms, but nevertheless can ...
Romero-Picó Amparo - - 2013
The opioid system is well recognized as an important regulator of appetite and energy balance. We now hypothesized that the hypothalamic opioid system might modulate the orexigenic effect of ghrelin. Using pharmacological and gene silencing approaches we demonstrate that ghrelin utilizes a hypothalamic kappa opioid receptor (KOR) pathway to increase ...
Seike Kensaku - - 2013
OBJECTIVES: Trichomonas vaginalis is one of the pathogens causing sexually transmitted infections. This microorganism is a common pathogen among women, but its significance as a cause of morbidity among men remains uncertain. We sought to determine the prevalence and morbidity of T. vaginalis infection in Japanese men with and without ...
Monajjemi Majid - - 2013
In BnNn cages or tubes, when the quasi borazine rings are attached to each other through a pair of common atoms of B and N, the bonding structure is named class A, On the other hand, there are some BnNn rings including a covalent bond between two atoms of B ...
Gu Junsi - - 2013
An electrochemical liquid-liquid-solid (ec-LLS) process that yields crystalline silicon at low temperature (80 °C) without any physical or chemical templating agent has been demonstrated. Electroreduction of dissolved SiCl(4) in propylene carbonate using a liquid gallium [Ga(l)] pool as the working electrode consistently yielded crystalline Si. X-ray diffraction and electron diffraction ...
Baglin T - - 2013
Oral direct inhibitors (ODIs) of thrombin and factor Xa are now approved as anticoagulant drugs. The first two drugs to complete phase III clinical trials for thromboprophylaxis in orthopaedic surgery and treatment of patients with atrial fibrillation or venous thromboembolism were dabigatran and rivaroxaban. These small molecules are given at ...
Riyaz-Ul-Hassan Syed - - 2013
In this study, methodologies were developed for cost-effective, rapid and user-friendly culture-independent detection of Salmonella in milk by real-time PCR. The SYBR Green based real-time PCR assay was standardized with primers targeting the Salmonella enterotoxin gene (stn) that have been earlier used for its detection by conventional PCR. Inclusivity tests ...
Giuliano François - - 2013
INTRODUCTION: Tadalafil, a long-acting phosphodiesterase type 5 inhibitor, is approved for treating signs and symptoms of benign prostatic hyperplasia (BPH) and erectile dysfunction (ED); tamsulosin, an alpha-blocker, is approved for treating signs and symptoms of BPH. AIM: To determine the effects of tadalafil or tamsulosin on sexual function, including ejaculation ...
Schüttler Christian - - 2013
Both, cis- and trans-3,4-disubstituted thiadiazolidines 5 and 6 can enantioselectively be obtained from thiadiazoles 2 which, in turn, are efficiently prepared from the respective 1,2-diketone by an improved protocol. An asymmetric ruthenium-catalyzed transfer hydrogenation followed by a diastereoselective hydride addition furnishes exclusively the cis-isomers 5 which, under acidic conditions, undergo ...
Huang Franklin W - - 2013
Systematic sequencing of human cancer genomes has identified many recurrent mutations in the protein coding regions of genes but rarely in gene regulatory regions. Here, we describe two independent mutations within the core promoter of TERT, the gene coding for the catalytic subunit of telomerase, which collectively occur in 50 ...
Horn Susanne - - 2013
Cutaneous melanoma occurs in both familial and sporadic forms. We investigated a melanoma-prone family through linkage analysis and high-throughput sequencing and identified a disease-segregating germ line mutation in the promoter of the telomerase reverse transcriptase (TERT) gene, which encodes the catalytic subunit of telomerase. The mutation creates a new binding ...
Li Xiangming - - 2013
The ability to generate a large area micropillar array with spatially varying heights allows for exploring numerous new interesting applications in biotechnology, surface engineering, microfluidics, etc. This letter presents a clever and straightforward method, called electrically modulated microtransfer molding (EM3), for generating such unique micro-structures from a silicon mold arrayed ...
Enright Brian P - - 2013
BACKGROUND: This study was conducted as part of an ILSI-HESIconsortium effort to assess the utility of circulating inhibin B as an early biomarker of testicular toxicity in rats. METHODS: Two known testicular toxicants were selected for use in this study: ethylene glycol monomethyl ether (EGME) and dibromoacetic acid (DBAA). EGME ...
Geist Matthias F - - 2013
Nanocomposites made from Na-Montmorillonite and metallo-supramolecular polyelectrolytes (MEPE) based on nickel and ditopic bis-terpyridine ligands are prepared by an aqueous synthesis. Intercalation is confirmed by IR-spectroscopy, thermogravimetric analysis and X-ray powder diffraction. The rheological response in the presence of an electric field of the dispersed nanocomposites in silicon oil is ...
Jacono Andrew A - - 2013
OBJECTIVE To aid the aesthetic surgeon in midface analysis and selection of treatment plans offering the greatest likelihood of success in midface rejuvenation. METHODS We performed a retrospective review of all patients who underwent surgical midface rejuvenation by a single surgeon. We recorded demographics, history, procedures, outcomes, and complications. Results ...
Lendrum Robbie A - - 2013
A case of pre-hospital administration of prothrombin complex concentrate to a patient anticoagulated with warfarin and with suspected intracranial haemorrhage is described. Effective, early reversal of anticoagulation by the time of arrival at hospital was achieved.
Mollet Karen - - 2013
The reactivity of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams with regard to the oxidant sodium periodate was evaluated, unexpectedly resulting in the exclusive formation of new 2-hydroxy-1,4-oxazin-3-ones through a C3C4 bond cleavage of the intermediate 4-formyl-3-hydroxy-β-lactams followed by a ring expansion. This peculiar transformation stands in sharp contrast with the known NaIO(4) -mediated oxidation of ...
Tomita Katsuyuki - - 2013
BACKGROUND: To predict the presence of asthma in adult patients with respiratory symptoms, we developed a scoring algorithm using clinical parameters. METHODS: We prospectively analysed 566 adult outpatients who visited Kinki University Hospital for the first time with complaints of nonspecific respiratory symptoms. Asthma was comprehensively diagnosed by specialists using ...
Case Amy A - - 2013
Abstract In this review we discuss the history of Hospice and Palliative Medicine (HPM) physician education in the United States over the last 20 years, as there has been dramatic growth in our specialty during this time. A Medline literature search was completed and we surveyed leaders in the field ...
Semark Birgitta - - 2013
PURPOSE: Socioeconomic factors have been suggested to influence the prescribing of newer and more expensive drugs. In the present study, individual and health care provider factors were studied in relation to the prevalence of differently priced drugs. METHODS: Register data for dispensed drugs were retrieved for 18 486 individuals in a ...
van Es J - - 2013
INTRODUCTION: Little is known about the natural history of clot resolution in the initial weeks of anticoagulant therapy in patients with acute pulmonary embolism (PE). Clot resolution of acute pulmonary embolism (PE) was assessed with either computed tomography pulmonary angiography (CT-scan) or perfusion scintigraphy (Q-scan) after 3 weeks of treatment. ...
Kim Gun-Hwa - - 2013
Type 2 diabetes mellitus (T2DM) is the most prevalent and serious metabolic disease affecting people worldwide. T2DM results from insulin resistance of the liver, muscle, and adipose tissue. In this study we used proteomic and bioinformatic methodologies to identify novel hepatic membrane proteins that are related to the development of ...
Tonduti Davide - - 2013
A novel leukoencephalopathy, termed hypomyelinating leukoencephalopathy affecting early myelinating structures (HEMS), was recently described. Here we report on two patients affected by HEMS with a clinical picture characterized by early-onset nystagmus and thereafter progressive cerebellar signs and mild spasticity predominantly affecting the legs. In one patient, who has the longest ...
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