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Results 501 - 550 of 2841
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Robinson Jeffrey M - - 2013
We present the discovery of microRNAs (miRNAs) in the calcisponges Sycon and Leucosolenia (phylum Calcarea), and potential miRNAs in the homoscleromorph Oscarella carmela (Phylum Homoscleromorpha), expanding the complement of poriferan miRNAs previously known only from the siliceous sponges (demosponges and hexactinellids). Comparison of these miRNAs with those previously described from ...
Xue Ting - - 2013
Although previous resting-state studies have reported abnormal functional cerebral changes in patients with migraine without aura (MwoA), few have focused on alterations in both regional spontaneous neuronal activity and corresponding brain circuits in MwoA patients during rest. Eighteen MwoA patients and 18 age- and gender-matched healthy controls (HC) were recruited ...
Rojas Asheebo - - 2013
The function of many ion channels is under dynamic control by coincident activation of G protein - coupled receptors (GPCRs), particularly those coupled to the G(α-s) and G(α-q) family members. Such regulation is typically dependent upon the subunit composition of the ionotropic receptor or channel as well as the GPCR ...
Kimple Michelle E ME Department of Medicine, University of Wisconsin, Madison, Madison, Wisconsin, USA. - - 2013
BTBR mice develop severe diabetes in response to genetically induced obesity due to a failure of the β-cells to compensate for peripheral insulin resistance. In analyzing BTBR islet gene expression patterns, we observed that Pgter3, the gene for the prostaglandin E receptor 3 (EP3), was upregulated with diabetes. The EP3 ...
Savage Tim - - 2013
BACKGROUND: There is evidence suggesting that first-born children and adults are anthropometrically different to later-borns. Thus, we aimed to assess whether birth order was associated with changes in growth and metabolism in childhood. METHODS: We studied 312 healthy pre-pubertal children: 157 first-born and 155 later-borns. Children were aged 3-10 years, ...
Read S - - 2013
The Bernoulli version of the spatial scan statistic is a well established method of detecting localised spatial clusters in binary labelled point data, a typical application being the epidemiological case-control study. A recent study suggests the inferential accuracy of several versions of the spatial scan statistic (principally the Poisson version) ...
Saastamoinen Marjo - - 2013
In insects, the length of larval development time typically influences adult body size and individual fitness, and hence development time can be expected to respond in an adaptive manner to variation in environmental conditions. In the wild, larval growth may be influenced by individual condition, which can be affected by ...
Schwoebel Frank - - 2013
Anemia of chronic inflammation is the most prevalent form of anemia in hospitalized patients. A hallmark of this disease is the intracellular sequestration of iron. This is a consequence of hepcidin-induced internalization and subsequent degradation of ferroportin, the hepcidin receptor and only known iron-export protein. This study describes the characterization ...
Varchi Greta - - 2013
Among the medical applications of nanoparticles, their usage as photosensitizer (PS) carriers for photodynamic therapy (PDT) has attracted increasing attention. In the present study we explored the morphological and photophysical properties of core-shell PMMA nanoparticles (PMMA-NPs) electrostatically post-loaded with the synthetic, water soluble 5,10,15,20-tetrakis(4-sulphonatophenyl)-porphyrin (TPPS(4)). pH response and singlet oxygen ...
Sano Kazuhiro - - 2013
Testosterone is known to play an important role in the regulation of male-type sexual and aggressive behavior. As an aromatised metabolite of testosterone, estradiol-induced activation of estrogen receptor α (ERα) may be crucial for the induction of these behaviors in male mice. However, the importance of ERα expressed in different ...
Wanitphakdeedecha R - - 2013
BACKGROUND: Melasma treatment modalities including topical and procedural therapy have been employed with variable results and high recurrence rate. OBJECTIVE: To quantitatively assess improvement in melasma and side effects after 1410 nm fractional photothermolysis laser treatments and to determine efficacy at 1-, 2- and 3-month follow-up after treatment. METHODS: Thirty volunteers ...
Reardon M A - - 2013
SUMMARY:Arachnoid webs are intradural extramedullary bands of arachnoid tissue that can extend to the pial surface of the spinal cord, causing a focal dorsal indentation of the cord. These webs tend to occur in the upper thoracic spine and may produce a characteristic deformity of the cord that we term ...
Schäfer Dominik - - 2013
All chemical reactions are influenced by temperature, however, temperature is usually not considered an important parameter which has to be varied or at least controlled in SECM measurements. A precise temperature-control unit was designed and integrated into a SECM setup which allows setting the temperature of the sample and the ...
Reil Angelika - - 2013
BACKGROUND: Neonatal immune neutropenia (NIN) is a rare, but potentially life-threatening, disorder caused by maternal alloantibodies recognizing paternal neutrophil antigens on fetal cells. Alloantibodies directed against the human neutrophil alloantigen system (HNA)-1 located on Fcγ receptor IIIb (FcγRIIIb) are most frequently implicated in NIN. In this report, we describe two ...
Pil Hwang Yong - - 2013
SCOPE: Increasing evidence indicates that polyphenols may protect against metabolic disease through activating AMP-activated protein kinase (AMPK). The aims of our study were to provide new data on the molecular mechanism(s) underlying the role of the phenolic compound, 3-caffeoyl, 4-dihydrocaffeoylquinic acid (CDCQ) from Salicornia herbacea, in the prevention of high ...
Grigore Mihaela - - 2013
Serous borderline ovarian tumors (BOTs) represent 25-30% of "nonbenign" serous ovarian tumors. We present HDlive pictures from a case of a serous BOT in a 25-year-old patient. Using HDlive technology allowed increased depth perception, and thus, provided a clear view of the tumor content and papillae, as well as the ...
Nonell S - - 2013
Singlet oxygen is a non-radical reactive oxygen species believed to play a major role in many photooxidation processes in connection with diverse photo-biological processes such as skin aging or photocarcinogenesis. Dimethylmethoxy chromanol (3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran) is a potent antioxidant used in cosmetic and pharmaceutical formulations. We have assessed the singlet oxygen quenching ...
Meijer Rosa J - - 2013
In model building and model evaluation, cross-validation is a frequently used resampling method. Unfortunately, this method can be quite time consuming. In this article, we discuss an approximation method that is much faster and can be used in generalized linear models and Cox' proportional hazards model with a ridge penalty ...
Federspiel Jerome J JJ Department of Health Policy and Management, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7411, - - 2013
To use coronary revascularization choice to illustrate the application of a method simulating a treatment's effect on subsequent resource use. Medicare inpatient and outpatient claims from 2002 to 2008 for patients receiving multivessel revascularization for symptomatic coronary disease in 2003-2004. This retrospective cohort study of 102,877 beneficiaries assessed survival, days ...
Lilja Tobias - - 2013
Rett syndrome (RTT) is a neurodevelopmental disorder with neurological symptoms, such as motor disorders and mental retardation. In most cases, RTT is caused by mutations in the DNA binding protein MeCP2. In mice, MeCP2 gene deletion has been reported to result in genome-wide increased histone acetylation. Transcriptional regulation of neurotrophic ...
Pozin Inna - - 2013
Although levodopa is the main treatment for dystonia, its role in cerebral palsy has not been assessed. We hypothesized that levodopa will improve upper limb function in individuals with cerebral palsy. Nine participants (age 16.8 ± 5.6 years) with quadriplegic cerebral palsy and upper limb dystonia were enrolled in this ...
Lin Chi-Wei - - 2013
ABSTRACT: BACKGROUND: The Objective Structured Clinical Examination (OSCE) has been widely applied as a high-stakes examination for assessing physicians' clinical competency. In 1992, OSCE was first introduced in Taiwan, and the authorities announced that passing the OSCE would be a prerequisite for step-2 medical licensure examination in 2013. This study ...
Gao Hong-Lian - - 2013
Abstract Objective: To assess the prevalence of musculoskeletal symptom of four different anatomical sites and the impact of menopause, age, and other factors on musculoskeletal symptoms. Methods: Generally healthy women aged 35 to 64 years were recruited from a general community in Beijing, People's Republic of China. Data were collected ...
Wei Lin-Hung - - 2013
Context:The inflammatory cytokine IL-6 is related to ovarian hyperstimulation syndrome (OHSS), although the functional role of IL-6 in OHSS remains largely unknown.Objective:A key feature of the IL-6 response is that its regulation is dependent on IL-6 trans-signaling via soluble IL-6 receptor-α (sIL-6Rα). The objective of the study was to elucidate ...
Corona Giovanni - - 2013
INTRODUCTION: The Atherosclerosis Risk in Communities (ARIC) algorithm is one of the most efficient instruments for the prediction of incident type 2 diabetes. Recently, it has been shown to predict another relevant cardiovascular (CV) risk factor, such as chronic kidney disease. AIM: To verify whether, in patients with erectile dysfunction ...
Cubbon Richard M RM Multidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, - - 2013
It is unclear whether diabetes mellitus (DM) is an adverse prognostic factor in chronic heart failure (CHF) of ischaemic and non-ischaemic aetiology managed with contemporary evidence-based care. In total, 1091 outpatients with CHF with reduced ejection fraction were prospectively observed for a mean of 960 days. Total and cardiovascular mortality ...
Benato Francesca F Department of Biology, University of Padova, Padova, - - 2013
AMBRA1 is a positive regulator of the BECN1-dependent program of autophagy recently identified in mouse. In this study, we cloned the full-length cDNAs of ambra1a and ambra1b zebrafish paralogous genes. As in mouse, both Ambra1 proteins contain the characteristic WD40 repeat region. The transcripts of both genes are present as ...
Davila Johanna - - 2013
The identification and the quantification of biomarkers or proteins is a real challenge to allow early detection of diseases. The functionalization of the biosensor surface has to be properly designed to prevent non-specific interactions and to specifically detect the biomolecule of interest. A multilayered nano-architecture, based on polyelectrolyte multilayers (PEM) ...
Hagan Teresa L TL Department of Acute and Tertiary Care, The University of Pittsburgh School of Nursing, PA, - - 2013
To report an analysis of the concept of self-advocacy among individuals with cancer to clarify its meaning, to differentiate this meaning with related concepts, and to unify understanding of the concept in cancer research and practice. Cancer survivors are increasingly required to assume an active role in their health care. ...
Kohashi Teruo - - 2013
A sample-heating system for spin-polarized scanning electron microscopy (spin SEM) has been developed and used for microscopic magnetization analysis at temperatures up to 500°C. In this system, a compact ceramic heater and a preheating operation keep the ultra-high vacuum conditions while the sample is heated during spin SEM measurement. Moreover, ...
Oude Rengerink Katrien K Department of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands. - - 2013
To identify and compare tools to assess Evidence-Based Practice (EBP) behaviour among healthcare professionals. Systematic review. MEDLINE, EMBASE, Cochrane Library, PsychInfo and CINAHL up to July 2011. Titles, abstracts and eligible full text articles were screened by two reviewers independently. Relevant data were extracted by one reviewer and checked by ...
Avouac Jérôme - - 2013
OBJECTIVE: To establish an expert consensus on which criteria are the most appropriate in clinical practice to refer patients with systemic sclerosis (SSc) for right heart catheterisation (RHC) when pulmonary hypertension (PH) is suspected. METHODS: A three stage internet based Delphi consensus exercise involving worldwide PH experts was designed. In ...
Reese Robert J - - 2013
OBJECTIVE: To examine demand characteristics, social desirability on clients' rating of working alliance using the Session Rating Scale (SRS; Miller, Duncan, & Johnson, 2000). METHOD: Clients (N = 102) at two sites were randomly assigned to one of three alliance feedback conditions: (a) IF-SRS completed in presence of therapist and ...
Schofield Timothy P - - 2013
AIMS: Alcohol-related harm places a significant strain on victims, perpetrators and society. The present research reports on how licensed alcohol outlet business hours may influence the reported incidence of interpersonal violence and the associated burden of disease. METHODS: We examined the relationship between alcohol outlet business hours and violent crime ...
Halbritter K - - 2013
BACKGROUND: Bleeding complications are common side effects of Vitamin-K antagonist (VKA) therapy. Data on the in-hospital management and outcomes of these bleeding events are scarce and information is mostly derived from trial cohorts. Objectives: The objective was to collect data on the management and clinical outcome of hospitalizations due to ...
Chen Shuqin - - 2013
To explore the association of polymorphisms in the region of three neighboring genes TRIT1, MYCL1 and MFSD2A with risk and clinicopathological features of gastric cancer, 19 tagging SNPs (tSNPs) in this region were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in a case-control study of 610 Chinese gastric cancer ...
Santillo Alexander Frizell - - 2013
Von Economo neurons (VEN) are bipolar neurons located in the anterior cingulate cortex (ACC) and the frontoinsular cortex (FI), areas affected early in behavioural variant frontotemporal dementia (bvFTD), in which VEN may constitute a selectively vulnerable cellular population. Aim A previous study has shown a selective loss of VEN in ...
Cordova Amado - - 2013
OBJECTIVE: To present a microsimulation model that addresses the methodological challenge of estimating the firm decision to self-insure. METHODOLOGY: The model considers the risk that the firm bears when self-insuring and the opportunity to mitigate that risk by purchasing stop-loss insurance. The model makes use of a structural, utility maximization ...
Aachoui Youssef Y Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, - - 2013
Caspases are either apoptotic or inflammatory. Among inflammatory caspases, caspase-1 and -11 trigger pyroptosis, a form of programmed cell death. Whereas both can be detrimental in inflammatory disease, only caspase-1 has an established protective role during infection. Here, we report that caspase-11 is required for innate immunity to cytosolic, but ...
Silva Rinaldo Florencio - - 2013
ABSTRACT Objective: to investigate the effects of soy isoflavones (Iso) and mechanical vibration (Vib) treatments alone or combined on bone extracellular matrix constituents of ovariectomized (Ovx) rats. Methods: 40 female Wistar rats at the age of 6 months were ovariectomized (Ovx) and 10 were sham-operated (sham) and after three months, ...
Alonso-Magdalena Paloma P Institute of Bioengineering and Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Miguel Hernandez University of Elche, Alicante, Spain. Alonso-Magdalena, - - 2013
The estrogen receptor β (ERβ) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ERβ selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances glucose-stimulated insulin secretion both in mouse and human islets. In ...
Burnett Arthur L - - 2013
INTRODUCTION: Although testosterone replacement therapy (TRT) is the preferred treatment for hypogonadism, information for patients using testosterone includes too frequent or prolonged erections as a potential side effect. AIM: To assess the frequency and risk of priapism or related adverse events (AEs) in hypogonadal men treated with a 1% testosterone ...
Strbac Georg D - - 2013
OBJECTIVES: Based on a novel standardized bovine specimen, the aim of this study was to investigate thermal effects of different irrigation methods during intermittent and graduated drilling. MATERIAL AND METHODS: Temperature changes during implant osteotomies (n = 320) of 10 and 16 mm drilling depths with various irrigation methods were investigated on manufactured ...
Dyer Martin J S - - 2013
There is now a plethora of new precision medicines for B-cell malignancy including 'classical' kinase inhibitors, rationally designed inhibitors of anti-apoptotic proteins and antibody or antibody drug/toxin conjugates with functional properties. Some are showing spectacular single agent activity in early phase clinical studies and may reduce or, in combination, even ...
Clark Andrew P-Z - - 2013
In an effort to favor straight polymer chains without crystalline grain boundaries, we have synthesized an amphiphilic conjugated polyelectrolyte, poly(fluorene-alt-thiophene) (PFT), which self-assembles in aqueous solutions to form cylindrical micelles. In contrast to many diblock copolymer assemblies, the semiconducting backbone runs parallel, not perpendicular, to the long axis of the ...
Parker Lindsay M - - 2013
Glucoprivation or hypoglycemia induces a range of counter regulatory responses including glucose mobilization, reduced glucose utilization and de novo glucose synthesis. These responses are mediated in part by the sympathetic nervous system. The aim of this study was to determine the chemical codes of sympathetic preganglionic neurons (SPN) activated by ...
Horn Morten A - - 2013
OBJECTIVES: X-linked adrenoleukodystrophy is an important cause of Addison's disease in boys, but less is known about its contribution to Addison's disease in adult males. After surveying all known cases of X-linked adrenoleukodystrophy in Norway in a separate study, we aimed to look for any missed cases among the population ...
Bauri Kamal - - 2013
Leucine/isoleucine side chain polymers are of interest due to their hydrophobicity and reported role in the formation of α-helical structures. The synthesis and reversible addition-fragmentation chain transfer (RAFT) polymerization of amino acid based chiral monomers, namely Boc-L-leucine methacryloyloxyethyl ester (Boc-L-Leu-HEMA, 1a), Boc-L-leucine acryloyloxyethyl ester (Boc-L-Leu-HEA, 1b), Boc-L-isoleucine methacryloyloxyethyl ester (Boc-L-Ile-HEMA, ...
Chang Mei-Chi - - 2013
Betel quid (BQ) chewing is an oral habit that increases the risk of oral cancer and oral submucous fibrosis (OSF), a precancerous condition showing epithelial atrophy and tissue fibrosis. Persistent fibroblast contraction may induce the fibrotic contracture of tissue. In this study, we found that areca nut extract (ANE) (200-1200 ...
Philipsen P A - - 2013
There is a general need for methods to obtain fast in vivo diagnosis of skin tumours. Raman spectroscopy measures molecular structure and may thus have potential as a tool for skin tumour diagnosis. The purpose of this study was to investigate how skin pigmentation influenced the Raman spectra and skin ...
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