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Results 451 - 500 of 2841
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Smailiene Dalia - - 2013
There is lack of consensus with respect to the preferred surgical procedure for the treatment of palatally impacted maxillary canines. The aim of this study was to evaluate post-treatment periodontal status of palatally impacted canines treated by open technique with free eruption and closed flap technique and compare it with ...
Kanto Laura - - 2013
We explored variation in the linguistic environments of hearing children of Deaf parents and how it was associated with their early bilingual language development. For that purpose we followed up the children's productive vocabulary (measured with the MCDI; MacArthur Communicative Development Inventory) and syntactic complexity (measured with the MLU10; mean ...
Schiele Nathan R - - 2013
Engineering strategies guided by developmental biology may enhance and accelerate in vitro tissue formation for tissue engineering and regenerative medicine applications. In this study, we looked toward embryonic tendon development as a model system to guide our soft tissue engineering approach. To direct cellular self-assembly, we utilized laser micromachined, differentially ...
Kimura Genki - - 2013
ABSTRACT BACKGROUND: RNA virus infections, such as rhinovirus and respiratory syncytial virus, induce exacerbations in patients with chronic obstructive pulmonary disease (COPD) and asthma, and the inflammation is corticosteroid refractory. The main aim of this study is to establish a murine model induced by a Toll-like receptor 3 (TLR3) agonist, ...
Toh C H - - 2013
BACKGROUND AND PURPOSE:Contrast leakage results in underestimation of the CBV of brain tumors. Our aim was to compare the diagnostic performance of DSC perfusion MR imaging without and with mathematic contrast-leakage correction in differentiating PCNSLs and glioblastomas.MATERIALS AND METHODS:Perfusion parameters-CBV, corrected CBV, and leakage coefficient-were measured in enhancing tumor portions ...
Gaymes Terry J - - 2013
Background Inactivation of the DNA mismatch repair pathway manifests as microsatellite instability, an accumulation of mutations that drives carcinogenesis. Here, we determined whether microsatellite instability in acute myeloid leukaemia and myelodysplastic syndrome correlated with chromosomal instability and PARP inhibitor sensitivity through disruption of DNA repair function. Design and Methods Acute ...
Demoranville Leonard Thomas - - 2013
Ion mobility spectrometers (IMS) have found widespread use for the screening of explosives, chemical warfare agents and illicit drugs. These instruments often rely on drift-time calibrants to perform qualitative identification. Such calibrants are suitable to determine the reduced mobility of compounds, but may not necessarily provide information on instrument performance. ...
Loera Muro Victor M - - 2013
Actinobacillus pleuropneumoniae (App) is the aetiological agent of porcine pleuropneumonia and is normally transmitted by aerosols and direct contact between animals. App has traditionally been considered an obligate pathogen of pigs and its presence in the environment has yet to be investigated. Here, the presence of App was detected in ...
Veenendaal Mve - - 2013
OBJECTIVE: We previously showed that maternal under-nutrition during gestation is associated with increased metabolic and cardiovascular disease in the offspring. Also, we found increased neonatal adiposity among the grandchildren of women who had been undernourished during pregnancy. In the present study we investigated whether these transgenerational effects have led to ...
Joseph Ryan - - 2013
Herein is described the chemoselective Cu(II)-HOBt promoted chemical ligation of glycosylamines and peptide thioacids to give N-glycosylated peptides. The method is distinguished from other chemical approaches to peptide N-glycosylation in that (1) it can be employed in the presence of unprotected N-terminal and Lys side chain amines; (2) it is ...
Therkelsen Kate E KE Boston University School of Medicine, Boston, MA, - - 2013
Intramuscular fat accumulates between muscle fibers or within muscle cells. We investigated the association of intramuscular fat with other ectopic fat deposits and metabolic risk factors. Participants (n=2945; 50.2% women; mean age 50.8 years) from the Framingham Heart Study underwent multidetector computed tomography scanning of the abdomen. Regions of interest ...
Chronis Demosthenis - - 2013
Nematode effector proteins originating from the esophageal gland cells play central roles in suppressing plant defenses and in the formation of the plant feeding cells required for growth and development of cyst nematodes. A gene (GrUBCEP12) encoding a unique ubiquitin carboxyl extension protein (UBCEP) that consists of a signal peptide ...
Tran Chieu D CD Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201, USA. - - 2013
We have successfully developed a simple and totally recyclable method to synthesize novel, biocompatible, and biodegradable composite materials from cellulose (CEL) and chitosan (CS). In this method, [BMIm(+) Cl(-) ], an ionic liquid (IL), was used as a green solvent to dissolve and synthesize the [CEL+CS] composites. Since, the IL ...
Skinner Jessica - - 2013
Considerable research has been done on childhood bullying, including its antecedents and consequences. Yet, with all of the attention on bullying, particularly school bullying, sibling bullying has been vastly overlooked. Sibling bullying is a type of violence prevalent in the lives of most children, but little is known about the ...
Teixeira Eduardo H - - 2013
Abstract Method: An open, naturalistic observational study design was used, in which a sample of seven boys between 10 and 14 years of age was assessed over 26 weeks. Results: The subjects were all diagnosed with conduct disorder (CD) and exhibited high levels of aggression that were refractory to psychosocial ...
Singh Dheeraj K - - 2013
Curcumin ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is an active component of turmeric; it is responsible for its characteristic yellow color and therapeutic potential, but its poor bioavailability remains a major challenge. In order to improve the bioavailability of curcumin, various approaches have been used. One of the possible approaches to increase the bioavailability of ...
Selver Ozlem Barut - - 2013
Three patients had unilateral vitreomacular traction (VMT) syndrome and the diagnosis was confirmed by spectral domain-type optical coherence tomography (OCT). All patients were female aged 51, 55 and 62 years. All denied surgical intervention. In one patient, rapid spontaneous resolution of the vitreomacular traction with a complete posterior vitreous detachment ...
Takasu Osamu O Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, - - 2013
The mechanistic basis for cardiac and renal dysfunction in sepsis is unknown. In particular, the degree and type of cell death is undefined. To evaluate the degree of sepsis-induced cardiomyocyte and renal tubular cell injury and death. Light and electron microscopy and immunohistochemical staining for markers of cellular injury and ...
Cornax Ingrid - - 2013
In many oviparous animals, bursting type atresia of ovarian follicles occurs during the reproductive cycle resulting in the escape of yolk into the extracellular compartment. In birds, this ectopic yolk is rapidly cleared by an unknown process that involves the appearance of yolk-engorged macrophage-like cells. To study this unique type ...
Hirschfield Gideon M - - 2013
Primary biliary cirrhosis (PBC) is an autoimmune disease characterized by clinical homogeneity among patients, an overwhelming female predominance, production of a multilineage immune response to mitochondrial autoantigens, inflammation of small bile ducts, and in some patients the development of fibrosis and cirrhosis. The targets in this disease are small bile ...
Braham Amel - - 2013
AIM: The study aimed to examine whether the Arabic version of the Comprehensive Assessment of At Risk Mental States (CAARMS) has good construct validity, concurrent validity and reliability. METHODS: Validity was established on a sample of 58 Tunisian adolescents and young adults aged between 16 and 30 years. These subjects ...
Giannakopoulou Trisevgeni - - 2013
PURPOSE: It is widely accepted that monocular deprivation results in improved visual performance in the non-pathological eye. The current study investigates the effect of deprivation due to severe impairment in one eye during late childhood or adulthood, on the spatial performance of the fellow 'good' eye. METHODS: Twenty patients (age: ...
Tsuchiya Kyoichiro K Naomi Berrie Diabetes Center and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, - - 2013
Insulin signaling in vascular endothelial cells (ECs) is critical to maintain endothelial function but also to mediate insulin action on peripheral glucose disposal. However, gene knockout studies have reached disparate conclusions. Thus, insulin receptor inactivation in ECs does not impair insulin action, whereas inactivation of Irs2 does. Previously, we have ...
Raczynska Ewa Daniela - - 2013
All possible twenty-three prototropic tautomers of neutral and redox adenine (nine amine and fourteen imine forms, including geometric isomerism of the exo =NH group) were examined in vacuo {DFT(B3LYP)/6-311+G(d,p)}. The NH ---> NH conversions as well as those usually omitted, NH ---> CH and CH ---> CH, were considered. An ...
Cubrilovic Dragana - - 2013
Due to its favorable physicochemical properties, DMSO is the standard solvent for sample storage and handling of compounds in drug discovery. To date, little attention was given to how DMSO influences protein-ligand binding strengths. In this study we investigated the effects of DMSO on different noncovalent protein-ligand complexes, in particular ...
Takahashi Kei - - 2013
Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) has been recognized as a promising target for cancer therapy because it can induce apoptotic cell death in tumor cells but not normal cells. Despite TRAIL exhibits specific tumoricidal activity, resistance to TRAIL-induced apoptosis in some tumor cells has been considered as ...
Lepage Come - - 2013
Little is known about patients with malignant digestive neuroendocrine tumours (MD-NETs). Although their incidence is increasing, MD-NETs remain a rare cancer, representing 1% of digestive cancers. Most MD-NETs are well-differentiated. MD-NET poorly differentiated carcinomas account for 20% of cases on average. Anatomical localisation of MD-NETs varied according to geographic region. ...
Drappatz Jan J Center for Neuro-Oncology, Dana Farber/Brigham & Women's Cancer Center, Dana Farber Cancer Institute, Boston, Massachusetts 02215, - - 2013
GRN1005 is a peptide-drug conjugate with the ability to penetrate the blood-brain barrier (BBB) and tumor cells by targeting the low-density lipoprotein receptor-related protein-1. We conducted a first-in-human phase I trial of GRN1005 in patients with recurrent glioma. Patients received GRN1005 by intravenous infusion every 3 weeks. Doses were escalated ...
Bravo S - - 2013
Caligus rogercresseyi is the most important parasite affecting Atlantic salmon and rainbow trout farming in sea water in Chile. After the outbreaks of the infectious salmon anaemia recorded in Region X from 2007, the salmon industry has expanded southwards to Region XI, where 60% of Atlantic salmon in Chile is ...
Morlando Maddalena - - 2013
Placenta accreta is a rare and potentially life-threatening complication of pregnancy characterized by abnormal adherence of the placenta to the uterine wall. A previously scarred uterus or an abnormal site of placentation in the lower segment are major risk factors. The aim of this study was to investigate the change ...
Htin Anthony Kwan Fu - - 2013
BACKGROUND: Outpatient parenteral antibiotic therapy has been shown to be efficacious, safe and cost-effective for a variety of infections. The data from managing infective endocarditis (IE) with Hospital in the Home (HITH) is limited. We evaluated the safety and outcomes of patients with IE treated with HITH at our centre. ...
Teixeira Catarina - - 2013
ABSTRACT: INTRODUCTION: Both fluid overload and oliguria are common complications in intensive care units (ICU) associated with increased mortality among critically ill patients, particularly in acute kidney injury (AKI). Although fluid overload is an expected complication of oliguria, it remains unclear whether their effects on mortality are independent of each ...
Terrasa Jean-Baptiste - - 2013
INTRODUCTION: A few studies have investigated the impact of photovaporization of the prostate (PVP) on sexual function and were mainly focused on erectile function. AIMS: To comprehensively evaluate the impact of PVP on sexual function. METHODS: A prospective evaluation involved sexually active patients needing surgical relief of bladder outlet obstruction ...
Liu Yue - - 2013
Due to having many low molecular mass substrates, CYP2E1 is of particular interests to the pharmaceutical industry. Many evidences showed that this enzyme can adopt multiple substrates to significantly reduce the oxidation rate of the substrates. The detailed mechanism for this observation is still unclear. In the current study, we ...
Lin Ning - - 2013
Using grafted b-cyclodextrin as targeting sites, Pluronic polymers have been introduced on the surface of cellulose nanocrystals by means of inclusion interaction between b-cyclodextrin and hydrophobic segment of the polymer. Because of steric stabilization effect, surface poly(ethylene glycol) chains facilitate the dispersion and compatibility of nanocrystals, which also enhance the ...
Birchwood Max - - 2013
AIMS: National EDEN aims to evaluate the implementation and impact on key outcomes of somewhat differently configured Early Intervention Services (EIS) across sites in England and to develop a model of variance in patient outcomes that includes key variables of duration of untreated psychosis (DUP), fidelity to the EIS model ...
Lee H J - - 2013
ABSTRACT BACKGROUND Interventional Pulmonology (IP) is an emerging sub-specialty with a dedicated 12 months of additional training after traditional pulmonary and critical care fellowships with fellowships across the country. A multiple choice question (MCQ) examination was developed to measure didactic knowledge acquired in IP fellowships. METHODS Interventional pulmonologists from ten ...
Kahn Jeffrey H - - 2013
BACKGROUND: The pairing of analysis of variance (ANOVA)-based analyses with designs lacking multiple measurement of client change may lead to conclusions that are inconsistent with theoretical expectations about how change will occur. Multilevel modeling (MLM), when used with multiple assessments of client outcomes, provides a flexible set of tools to ...
Emami Shahram - - 2013
Introns are often added to transgenes to increase expression, although the mechanism through which introns stimulate gene expression in plants and other eukaryotes remains mysterious. While introns vary in their effect on expression, it is unknown whether different genes respond similarly to the same stimulatory intron. Furthermore, the degree to ...
Sukumar Piruthivi P Division of Cardiovascular and Diabetes Research, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, - - 2013
Insulin resistance is characterized by excessive endothelial cell generation of potentially cytotoxic concentrations of reactive oxygen species. We examined the role of NADPH oxidase (Nox) and specifically Nox2 isoform in superoxide generation in two complementary in vivo models of human insulin resistance (endothelial specific and whole body). Using three complementary ...
Aabye Martine G - - 2013
Interferon-γ release assays (IGRA) are probably the most accurate tests for detection of latent M.tuberculosis infection, but IGRAs are labour intensive and transport of samples over longer distances is difficult. IP-10 is expressed at 100-fold higher levels than IFN-γ, and IP-10 release assays have comparable performance to IGRA. The aim ...
Mawanda Francis - - 2013
Late-onset Alzheimer's disease (AD) is the most prevalent cause of dementia among older adults, yet more than a century of research has not determined why this disease develops. One prevailing hypothesis is that late-onset AD is caused by infectious pathogens, an idea widely studied in both humans and experimental animal ...
George Alex A Texas Children's Hematology Center, Texas Children's Hospital, Houston, TX 77030, USA. - - 2013
Chronic inflammation has emerged as an important pathogenic mechanism in sickle cell disease (SCD). One component of this inflammatory response is oxidant stress mediated by reactive oxygen species (ROS) generated by leukocytes, endothelial cells, plasma enzymes, and sickle red blood cells (RBC). Sickle RBC ROS generation has been attributed to ...
Baumstarck K K EA3279 Self-perceived Health Assessment Research Unit, School of Medicine, Aix-Marseille Université, Marseille, - - 2013
Predictive factors of long-term disability in patients with relapsing-remitting multiple sclerosis (RR-MS) are well known, but the weight of these factors does not explain the entire change of disability. Few studies have examined the predictive value of quality of life (QoL). To determine the value of the initial level of ...
Cimadevilla Claire - - 2013
OBJECTIVE: Previous studies suggested an independent prognostic value of B-type natriuretic peptide (BNP) in aortic valve stenosis (AS) but were impeded by small sample sizes and inclusion of relatively selected young patients. We aimed to evaluate the relationship among N-terminal fragment of proBNP (Nt-proBNP), AS severity, symptoms and outcome in ...
Thomas Romain - - 2013
• Premise of the study: Through a comparative study of the anatomy of palm stems and the development of an interactive web-based tool, the present paper aims to provide a method of identifying palm stems. The stem determination will allow specialists in archaeology and paleontology to better exploit palm fossils ...
Kohno Jin - - 2013
Epithelioid angiomyolipoma has malignant potential; however, no effective therapy has been established for advanced cases. A 50-year-old woman with a history of right nephrectomy for epithelioid angiomyolipoma was referred to our institution. Computed tomography and magnetic resonance imaging showed multiple tumors in her lung, liver and pelvic cavity. The liver ...
Peraramelli S - - 2013
BACKGROUND: TFPI is a multi-Kunitz domain protease inhibitor that down-regulates the extrinsic coagulation pathway by inhibiting FXa and FVIIa. OBJECTIVES: To investigate the role of the three Kunitz domains (KD) of TFPI in FVIIa inhibition using full length TFPI (TFPI(fl) ) and truncated TFPI constructs. METHODS: Inhibition of FVIIa with/without ...
Mészáros V - - 2013
The purpose of the present study was to examine the construct validity of the Hungarian language version of the Maslach Burnout Inventory-Human Services Survey (MBI-HSS). A sample of 653 healthcare professionals (420 physicians and 233 nurses and nursing assistants) completed the MBI-HSS. A series of confirmatory factor analyses showed that ...
Zhang De-Qing - - 2013
ABSTRACT: BACKGROUND: The purpose of this study was to investigate the anti-tumor effect and explore the mechanisms of celecoxib (a selective cyclooxygenase-2 inhibitor) combined with 5-fluorouracil (5-FU) on the treatment of human colorectal cancer in a BALB/C nude mouse subcutaneous xenograft model. METHODS: Effects of celecoxib combined with 5-FU on ...
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