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Mellado Lagarde Marcia M MM Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, - - 2013
Mammalian auditory hair cells (HCs) are inserted into a well structured environment of supporting cells (SCs) and acellular matrices. It has been proposed that when HCs are irreversibly damaged by noise or ototoxic drugs, surrounding SCs seal the epithelial surface and likely extend the survival of auditory neurons. Because SCs ...
Magyar Adam - - 2013
The deprotonation of naturally-occurring zeaxanthin (Zea) radical cations (Zea(•+)) to form neutral radicals (#Zea(•)) and their involvement in the qE portion of non-photochemical quenching (NPQ) was examined. The radical cations are weak acids, and readily deprotonate to a long-lived neutral radical (#Zea(•)) that could serve as long-lived quenching sites. When ...
Fritzsche Marco - - 2013
The cell cortex is a thin network of actin, myosin motors, and associated pro-teins that underlies the plasma membrane in most eukaryotic cells. It enables cells to resist extracellular stresses, perform mechanical work, and change shape. Cortical structural and mechanical properties depend strongly on the relative turnover rates of its ...
Bourque Josiane - - 2013
Introduction. Clozapine, the most widely used option in treatment-resistant schizophrenia, has been shown to be superior to other antipsychotic medications in improving cognitive function in patients. However, the results have not been consistent and the mechanisms underlying this effect have not been elucidated. Thus, the purpose of the present study ...
Babaei Sepideh - - 2013
ABSTRACT: BACKGROUND: Delineating the molecular drivers of cancer, i.e. determining cancer genes and the pathways whichthey deregulate, is an important challenge in cancer research. In this study, we aim to identify pathwaysof frequently mutated genes by exploiting their network neighborhood encoded in the proteinproteininteraction network. To this end, we introduce ...
Rieken Stefan - - 2013
ABSTRACT: BACKGROUND: Radiotherapy is controversially discussed in the management of benign disorders for fear of late sequelae such as tumor induction. This study was initiated to investigate long-term toxicity, treatment outcome and prognostic factors after radiotherapy (RT) in patients with pituitary adenomas. METHODS: 92 patients with pituitary adenomas were included ...
Abe Yusaku - - 2013
Measles virus (MV) isolates from patients with subacute sclerosing panencephalitis (SSPE) differ from wild-type MV virologically. However, few animal models have reported viruses with characteristics of the SSPE virus. The MV Edmonston strain was inoculated into the subarachnoid space of nude mice. All nude mice displayed weight loss and required ...
Jove Maurice - - 2013
Desirudin, administered 30 minutes before total hip arthroplasty is superior to enoxaparin in preventing proximal deep vein thrombosis (DVT) and pulmonary embolism (PE) with similar bleeding. The purpose of this study was to determine the safety of desirudin in patients undergoing elective total knee arthroplasty (TKA) when the first dose ...
Cheuvront Samuel N - - 2013
Dehydration (body water deficit) is a physiologic state that can have profound implications for human health and performance. Unfortunately, dehydration can be difficult to assess, and there is no single, universal gold standard for decision making. In this article, we review the physiologic basis for understanding quantitative dehydration assessment. We ...
Bierhoff Marieke - - 2013
We report a case of an HIV infected patient who was successfully treated with ritonavir/lopinavir (r/LPV) monotherapy for several years. He presented with neurological symptoms and high HIV RNA levels in cerebrospinal fluid (CSF). Sequencing of the HIV from the CSF revealed mutations in the protease gene reflecting resistance against ...
Li Ji - - 2013
Triblock copolymer Pluronic F127 has been used to form composites with zein, a corn protein and co-product of bioethanol industry, to alleviate its natural brittleness. We found that, at low F127 loadings (0~35%), the plasticizing effect was dominant, and the elongation at break of zein composite film containing 35% F127 ...
Santos André Peralta - - 2013
Emergency department (ED) triage systems aim to direct the best clinical assistance to those who are in the greatest urgency and guarantee that resources are efficiently applied.The study's purpose was to determine whether the Manchester Triage System (MTS) second version is a useful instrument for determining the risk of hospital ...
Lu Yong Y Laboratory Medicine Center, Yinzhou People's Hospital, Ningbo, China. - - 2013
This report describes the results of the sequence analysis of a methicillin-susceptible strain of catalase-negative Staphylococcus lugdunensis. Molecular characterization of the deduced sequence revealed a novel point mutation in the catalase gene. To our knowledge, this is the first report of a catalase-negative S. lugdunensis strain, although catalase-negative isolates of ...
Lopes Ana - - 2013
Background: Chronic urticaria is associated with an immune dysregulation usually mediated by T lymphocytes. Recently, Th17 and Tc17 have been implicated in autoimmune diseases; however, their role in urticaria is not clear yet. Methods: For the study we recruited 20 patients [10 of them had autoreactive chronic spontaneous urticaria (positive ...
Gavlighi Hassan A - - 2013
Gum tragacanth derived from the plant "goat's horn" (Astragalus sp.) has a long history of use as a stabilizing, viscosity-enhancing agent in food emulsions. The gum contains pectinaceous arabinogalactans and fucose-substituted xylogalacturonans. In this work, gum tragacanth from Astragalus gossypinus was enzymatically depolymerized using Aspergillus niger pectinases (Pectinex® BE Colour). ...
Sumiya Shigehiro - - 2013
A coumarin-amide-dipicolylamine linkage (L) was synthesized and used as a fluorescent receptor for metal cations in water. The receptor dissolved in water with neutral pH shows almost no fluorescence due to the photoinduced electron transfer (PET) from the amide and amine nitrogens to the excited state coumarin moiety. Coordination of ...
Gallego Almudena - - 2013
A coordination polymer is fully exfoliated just by solvent-assisted interaction. The soft-delamination process results from the structure of the starting material, which shows a layered structure with weak layer-to-layer interactions and cavities with the ability to locate several solvents in an unselective way. These results represent a significant step forward ...
Napoli Nicola N Università Campus Bio-Medico di Roma, 83-00155 Rome, - - 2013
Patients on long-term bisphosphonate therapy may have an increased incidence of low-energy subtrochanteric and diaphyseal (SD) femoral fractures. However, the incidence and risk factors associated with these fractures have not been well defined. The objective of the study was to determine the incidence of and risk factors for low-energy SD ...
Becker Adrian - - 2013
Abstract Objectives: To propose invasive cervical root resorption (ICRR) as an unrecognized and/or overlooked etiologic factor in the failure of response of an impacted tooth to orthodontic traction and to underline the importance of cone beam computerized tomography (CBCT) for early and accurate diagnosis of ICRR. Materials and Methods: Fourteen ...
Wei Xu-Hong - - 2013
At present, effective drug for treatment of neuropathic pain is still lacking. Recent studies have shown that the ligands of translocator protein (TSPO, 18 kDa), a peripheral receptor for benzodiazepine, modulate inflammatory pain. Here, we report that TSPO was upregulated in astrocytes and microglia in the ipsilateral spinal dorsal horn ...
Furrer Mona A - - 2013
Hexanuclear thiolato-bridged arene ruthenium metalla-prisms of the general formula [(p-cymene)(6) Ru(6) (SR)(6) (tpt)(2) ](6+) (R=CH(2) Ph, CH(2) C(6) H(4) -p-tBu, CH(2) CH(2) Ph; tpt=2,4,6-tris(4-pyridyl)-1,3,5-triazine), obtained from the dinuclear precursors [(p-cymene)(2) Ru(2) (SR)(2) Cl(2) ], AgCF(3) SO(3) and tpt, have been isolated and fully characterised as triflate salts. The metalla-prisms are ...
Hou Chun-Han - - 2013
ABSTRACT: INTRODUCTION: Osteoarthritis (OA) is the most common degenerative joint disease that involving in degradation of articular cartilage. The exact etiology of OA is not completely understood. CCN4 is related to up-regulation in the cartilage of patient with osteoarthritis. Previous studies have shown that CCN4 might be associated with the ...
Patel Vikas H - - 2013
An initial carbamazepine concentration may initially be supratherapeutic, therapeutic, or even subtherapeutic only to persist to rise over time. The aim of this study was to report the frequency of toxic carbamazepine concentrations continuing to rise and to estimate how often an initially therapeutic or subtherapeutic concentration misrepresents the potential ...
Lu Ying - - 2013
Eriocalyxin B (EriB), a diterpenoid isolated from Isodon eriocalyx, was previously reported to have antitumor effects via multiple pathways, and these pathways are related to immune responses. In this study, we demonstrated that EriB was efficacious in experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Treatment with EriB ...
Behler Kristopher D - - 2013
Compounds rich in nitrogen are attracting significant interest not only because of their high energy content, but becasue they are potentially more environmentally benign in comparison to conventional energetic materials. Given this interest, it is desirable to understand their molecular composition and structural variations with pressure in order to derive ...
Fadiel A A Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, USA. - - 2013
Intrauterine growth restriction (IUGR) has been associated with exposure to polyaromatic hydrocarbons (PAHs) which are released in the combustion of oil, fuel, gas, garbage, and tobacco. Pregnant women exposed to PAHs are at risk of the effects of these environmental toxins; for example, benzo-α-pyrene (BαP) is able to enter the ...
Sun Baohua B Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, - - 2013
The development of mature B cells from hematopoietic stem cells is a strictly orchestrated process involving multiple regulatory genes. The transcription factor Sox4 is required for this process, but its role has not been systematically studied, and the underlying mechanisms remain unknown. To determine when and how Sox4 functions in ...
Ganapathy M K - - 2013
Objective: To investigate the effect of pre-transition duration on acoustic change complex (ACC) for speech and tonal stimulus. Design: Cortical potentials were recorded for consonant-vowel syllable and tonal complex stimuli with varying pre-transition durations. Study sample: Ten individuals (three male and seven female) in the age range from 18 to ...
Appelboom Geoffrey G Department of Neurological Surgery, The Neurological Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. - - 2013
It is still unknown whether subsequent perihaematomal oedema (PHE) formation further increases the odds of an unfavourable outcome. Demographic, clinical, radiographic and outcome data were prospectively collected in a single large academic centre. A multiple logistic regression model was then developed to determine the effect of admission oedema volume on ...
Holvoet Sébastien - - 2013
Background: Pre-clinical and clinical studies have evaluated the efficacy of probiotics in allergy. However, predictive in vitro systems for rational strain selection are still missing. Methods: We developed a novel in vitro screening system for the characterization of probiotics with anti-allergic potential. In this model, human peripheral blood mononuclear cells ...
L'Episcopo Francesca F Oasi Maria Institute for Research and Care on Mental Retardation and Brain Aging, Neuropharmacology Section, 94018 Troina, - - 2013
Aging and exposure to environmental toxins including MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) are strong risk factors for developing Parkinson's disease (PD), a common neurologic disorder characterized by selective degeneration of midbrain dopaminergic (DAergic) neurons and astrogliosis. Aging and PD impair the subventricular zone (SVZ), one of the most important brain regions for adult ...
Bando Tetsuya - - 2013
In the cricket Gryllus bimaculatus, missing distal parts of the amputated leg are regenerated from the blastema, a population of dedifferentiated proliferating cells that forms at the distal tip of the leg stump. To identify molecules involved in blastema formation, comparative transcriptome analysis was performed between regenerating and normal unamputated ...
Leroy Jef L - - 2013
There is a growing concern that food or cash transfer programs may contribute to overweight and obesity in adults. We studied the impact of Mexico's Programa de Apoyo Alimentario (PAL), which provided very poor rural households with cash or in-kind transfers, on women's body weight. A random sample of 208 ...
Wang Chenbo C Department of Chemistry, Boston College, Chestnut Hill, MA 02467, - - 2013
The first broadly applicable set of protocols for efficient Z-selective formation of macrocyclic disubstituted alkenes through catalytic ring-closing metathesis (RCM) is described. Cyclizations are performed with 1.2-7.5 mol% of a Mo- or W-based monoaryloxide pyrrolide (MAP) complex at 22 °C and proceed to complete conversion typically within two hours. Utility ...
Djoumad Abdelmadjid - - 2013
Tranosema rostrale ichnovirus (TrIV) is a polydnavirus (PDV) transmitted by the endoparasitic wasp T. rostrale to its host Choristoneura fumiferana during oviposition. PDV genes are expressed in infected caterpillars, causing physiological disturbances that promote the survival of the developing endoparasite. The previously sequenced genome of TrIV contains ~86 genes organized ...
Toulemonde P - - 2013
The effect of selenium substitution by sulfur in the Tl(1-y)Fe(2-z)Se(2) antiferromagnet was studied by x-ray and electron diffraction, magnetization and transport measurements. Tl(0.8)Fe(1.5)(Se(1-x)S(x))(2) (nominal composition) solid solution was synthesized in the full x range (0 ≤ x(S) ≤ 1) using the sealed tube technique. No superconductivity was found down to 4.2 K in the series ...
Chen Robert H C RH Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5S 3H2, - - 2013
α-Synuclein is an abundant presynaptic protein and a primary component of Lewy bodies in Parkinson disease. Although its pathogenic role remains unclear, in healthy nerve terminals α-synuclein undergoes a cycle of membrane binding and dissociation. An α-synuclein binding assay was used to screen for vesicle proteins involved in α-synuclein membrane ...
Navajas Joaquin - - 2013
When a face is flashed to an observer, a large negative component is elicited in the occipitotemporal cortex at ∼170 ms from the onset of presentation (N170). Previous studies have shown that the average N170 is correlated with conscious face perception; however, the single-trial mechanisms underlying such modulation remain largely ...
Shah Shreyansh - - 2013
Thrombosed aneurysms are difficult to visualize with digital subtraction angiography. We report a case of subarachnoid hemorrhage from a thrombosed ruptured aneurysm which was undetected on digital subtraction angiography but was visualized with cone beam volume CT. To our knowledge, this is the first report highlighting the utility of cone ...
Volpe Ellen M - - 2013
Adolescent girls with older male main partners are at greater risk for adverse sexual health outcomes than other adolescent girls. One explanation for this finding is that low relationship power occurs with partner age difference. Using a cross-sectional, descriptive design, we investigated the effect of partner age difference between an ...
Wu Cheng-Jang - - 2013
Objective: Asthma is a chronic respiratory disorder characterized by airway hyperreactivity, eosinophilic infiltration, high titer of allergen-specific IgE, and overproduction of T helper 2 (Th2) cytokines. Antigen combined with an appropriate adjuvant and administrated through the proper route can elicit suitable immunological responses to protect humans and animals from diseases. ...
Varade Dharmesh - - 2013
Novel and intriguing one-pot in situ method for the preparation of nanostructured Pt-clay materials under simple conditions is reported. In this synthesis, inorganic clay minerals such as synthetic hectorite ("Laponite XLG") or natural montmorillonite ("Kunipia F") serves as a mild and effective reducing agent for Pt ions, which is uncommon ...
Jiménez-Rosales Angélica - - 2013
Cardiovascular disease is originated in the vascular endothelium, which controls the homeostasis and the filtration and diffusion of molecules from blood to the tissues. The classical cardiovascular risk factors (CRFs) act directly on the endothelium through an increase in the production of reactive oxygen species, promoting an endothelial activation mediated ...
Luo Yang - - 2013
BACKGROUND: MicroRNAs (miRNAs) are present in body fluids and may have the potential to serve as disease biomarkers. This study explored the clinical value of miRNAs in serum and urine as biomarkers for idiopathic childhood nephrotic syndrome (NS).METHODS: We obtained serum samples from 159 NS children (24 steroid resistant and ...
Kang Pil Jung PJ Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, - - 2013
Cells of the budding yeast Saccharomyces cerevisiae select a site for polarized growth in a specific pattern that depends on their cell type. Haploid a and α cells bud in the axial budding pattern, which requires assembly of a landmark that includes the Bud4 protein. To understand how an axial ...
Wang Zhihui Z Department of Pathology, The Ohio State University, Columbus, OH 43210, - - 2013
IL-35 is a member of the IL-12 family of cytokines that is comprised of an IL-12 p35 subunit and an IL-12 p40-related protein subunit, EBV-induced gene 3 (EBI3). IL-35 functions through IL-35R and has a potent immune-suppressive activity. Although IL-35 was demonstrated to be produced by regulatory T cells, gene-expression ...
Melymuk Lisa - - 2013
Land use regression (LUR), a geographic information system (GIS), and measured air concentrations were used to identify potential sources of semi-volatile organic contaminants (SVOCs) within an urban/suburban region, using Toronto, Canada as a case study. Regression results suggested that air concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), polycyclic ...
Li Yunfeng - - 2013
Synthesize while the iron is hot: The synthesis of 2-vinylquinolines via a FeCl(3) -catalyzed CH sp(3) functionalization and a subsequent CN cleavage is reported. The method is simple and efficient, and avoids the use of organometallic compounds. A variety of 2-vinylquinolines were obtained from readily available 2-methylquinolines with moderate to ...
Huang Yiping Y Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2013
Our previous reports showed that the cisplatin exposure induced the ATM-dependent phosphorylation of ΔNp63a, which is subsequently involved in transcriptional regulation of gene promoters encoding mRNAs and microRNAs in squamous cell carcinoma (SCC) cells upon cisplatin-induced cell death. We showed that phosphorylated (p)-ΔNp63a plays a role in upregulation of pro-apoptotic ...
Frankenberg Stephen - - 2013
Early cell lineage specification in eutherian mammals results in the formation of a pluripotent inner cell mass (ICM) and trophoblast. By contrast, marsupials have no ICM. Here, we present the first molecular analysis of mechanisms of early cell lineage specification in a marsupial, the tammar wallaby. There was no overt ...
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