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Results 701 - 750 of 3451
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Baradel Nathalie - - 2013
Polymers that toe the line: Well-defined linear polystyrene chains containing precisely positioned hexose moieties (mannose, galactose, and N-acetylglucosamine) were synthesized by a sequence-controlled polymerization approach followed by a series of site-selective modification steps. Such multifunctional single-chain hexose arrays associate specifically with complementary lectins.
Feelders Richard A - - 2013
Context:Cushing's disease (CD) is associated with serious morbidity and, when suboptimally treated, an increased mortality. Although surgery is the first-line treatment modality for CD, hypercortisolism persists or recurs in an important subset of patients. Considering the deleterious effects of uncontrolled CD, there is a clear need for effective medical therapy.Objective:In ...
Huang Wenyu - - 2013
The present work describes, for the first time, the use of a new and strong complexing agent, Ethylenediamine-N,N'-disuccinic acid (EDDS) in the homogeneous Fenton process. The effect of H2O2 concentration, Fe(III)-EDDS concentration, pH value and oxygen concentration on the homogeneous Fenton degradation of Bisphenol A (BPA) used as a model ...
Rodríguez-Estival Jaime - - 2013
Lead (Pb) is a highly toxic metal that can induce oxidative stress and affect the immune system by modifying the expression of immunomodulator-related genes. The aim of the present study was to investigate the association between Pb exposure and the transcriptional profiles of some cytokines, as well as the relationship ...
Yoneyama Mitsuru - - 2013
Accelerometry-based gait analysis is widely recognised as a promising tool in healthcare and clinical settings since it is unobtrusive, inexpensive and capable of providing insightful information on human gait characteristics. In order to expand the application of this technology in daily environments, it is desirable to develop reliable gait measures ...
Komosa M - - 2013
The study included 249 horses belonging to three horse breeds. Konik horses, comprising the first group, are an example of breed similar to the extinct Tarpan. In our study, these horses were taken to be a primitive anatomical model of the horse body. The other groups comprised the Polish Half-bred ...
Demiri E C - - 2013
The dorsoradial flap is a recently described cutaneous flap, which is harvested from the distal forearm and indicated for covering dorsal soft tissue defects of the hand and thumb. Vascularization of the flap is assured by a cutaneous branch of the radial artery, which arises at the level of the ...
Alsancak Serap - - 2013
Background:Infantile tibia vara is an acquired form of tibial deformity associated with tibial varus and internal torsion. Several methods have been described for orthotics treatment. The purpose of this study was to determine the effectiveness of orthotics treatment in infantile tibia vara.Study design:Controlled trial.Objective:The aim of this study was to ...
Wang Gang - - 2013
Primary cilia, which emanate from the cell surface, exhibit assembly and disassembly dynamics along the progression of cell cycle. However, the mechanism that links ciliary dynamics and cell cycle regulation remains elusive. Here, we report that Polo-like kinase 1 (Plk1), one of the key cell cycle regulators, which regulate centrosome ...
Zhang Di - - 2013
Various radical-scavenging activities (RSA) assessment assays are based on discrete mechanisms and on using different radical sources. Few studies have analyzed the structural significance of flavonoids in their peroxyl radical activities in the oxygen radical absorbance capacity (ORAC) assay. In this study, the RSA of 13 flavonoids in two ORAC ...
Seok Yangki - - 2013
Extraction of small specimens such as excised blebs through trocar site is a simple procedure. However, working thoracotomy is mandatory for removal of large solid intrathoracic tumors. We have used an instrument to morcellate a specimen in semi-exteriorized pouch during video-assisted thoracoscopic surgery. Morcellation has provided the solution for removing ...
Wong Alyssa S W - - 2013
Abstract An original technique of transcervical intralesional vasopressin injection that allowed direct infiltration to submucous myomas under hysteroscopic control is described. Five patients with a symptomatic submucous myoma 1.5-5 cm in size scheduled for hysteroscopic myomectomy were recruited. The time required for vasopressin injection was less than 3 minutes in all ...
Hira Riichiro - - 2013
Functional clustering of neurons is frequently observed in the motor cortex. However, it is unknown if, when, and how fine-scale (<100 μm) functional clusters form relative to voluntary forelimb movements. In addition, the implications of clustering remain unclear. To address these issues, we conducted two-photon calcium imaging of mouse layer ...
Xu Xiu-Hua - - 2013
An unusual NaH-mediated remote anionic 1,5-thia-Fries rearrangement reaction was developed. This method provides an efficient approach for the regioselective synthesis of not only 2-(2-hydroxyphenyl)-3-indole triflones but also related 3-sulfonylindoles.
Burshtein Gregory - - 2013
During recent years there has been increasing interest in the Lycopodium alkaloid huperzine A as a potential therapeutic agent for neurodegenerative diseases. This study aimed to characterize huperzine A's permeability across the enterocyte barrier along the gastrointestinal tract with an emphasis on the effect of ionization on the drug absorption. ...
van Heeswijk Ruud B - - 2013
BACKGROUND: -The goal of this study was to characterize the performance of (19)F cardiac magnetic resonance (CMR) for the specific detection of inflammatory cells in a mouse model of myocarditis. Intravenously administered perfluorocarbons (PFC) are taken up by infiltrating inflammatory cells and can be detected by fluorine-19 ((19)F) CMR. (19)F-labeled ...
Rajamalli P - - 2013
We report, for the first time, an in situ formation of two-component hydrogels from pyridine derivatives of poly(aryl ether) dendrons and tartaric acid. The two-component system (dendron + acid) undergoes J-type aggregation, leading to fibrillar type self-assembly in THF-water mixture along with blue (470 nm) and green (500 nm) intrinsic ...
Iwasaki Takahiro - - 2013
In non-apoptotic cells, the phosphorylation level of myosin II is constantly maintained by myosin kinases and myosin phosphatase. During apoptosis, caspase-3-activated ROCK-I triggers hyperphosphorylation of myosin II, leading to membrane blebbing. Although inhibition of myosin phosphatase could also contribute to myosin II phosphorylation, little is known about the regulation of ...
Saatchi M - - 2013
The objective of this study was to estimate accuracies of direct genomic breeding values (DGV) for nationally evaluated traits of 1,081 American (AMH), 100 Argentine (ARH), 75 Canadian (CAH) and 395 Uruguayan (URH) Hereford animals genotyped using the Illumina BovineSNP50 BeadChip. Deregressed estimated breeding values (DEBV) were used as observations ...
Sardh Eliane - - 2013
BACKGROUND/AIMS: Previous studies have indicated a high risk of hepatocellular carcinoma in acute hepatic porphyrias. In this retrospective study we present the incidence of primary liver cancer and clinical characteristics in a cohort of 179 acute porphyria patients above the age of 50 years. METHODS: Twenty-three cases with primary liver cancer ...
Shmarina Galina - - 2013
ABSTRACT: BACKGROUND: It is well known that the disease progression in cystic fibrosis (CF) patients may be diverse in subjects with identical mutation in CFTR gene. It is quite possible that such heterogeneity is associated with TNF-alpha and/or LT-alpha gene polymorphisms since their products play a key role in inflammation. ...
Shapiro M - - 2013
This is a case report on a 26-year-old woman with metastatic mandibular osteosarcoma to the lung. A video-assisted thorascopic surgery (VATS) completion left upper lobe lobectomy was attempted, but was converted to a thoracotomy when anomalous pulmonary vein drainage (APVD) was identified. There were no other anomalies found and the ...
Ibrahim Michael - - 2013
The t-tubule system in ventricular cardiomyocytes is essential for synchronous Ca(2+) handling, and therefore efficient contraction. T-tubular remodeling is a common feature of heart disease. In this review, we discuss whether t-tubular remodeling can be reversed and which factors may be implicated in this process. In particular, we focus on ...
Nijamudheen A - - 2013
Structures and mechanism of pattern formation for the radical fluorination on selected polyaromatic hydrocarbons (PAH) has been studied using Density Functional Theory (DFT) methods. Our study reveals that the F˙ radical addition occurs preferentially at the edges of PAHs followed by the hopping of F˙ to the centre due to ...
Connor James - - 2013
BACKGROUND/AIM: Discussions of doping often report Goldman's sensational results that half of the elite athletes asked would take a drug that guaranteed sporting success which would also result in their death in 5 years' time. There has never been any effort to assess the properties of the 'Goldman dilemma' or ...
Kovacs-Nolan Jennifer - - 2013
β-1,4-Mannobiose (MNB) has been shown to exert prebiotic activity and modulate mucosal gene expression. In this study, the immune-modulating effect of MNB in healthy and endotoxemic mice and its role in Toll-like receptor (TLR) 2/4-mediated macrophage activation were investigated. Mice were supplemented daily with MNB (0, 5, 10, or 25 ...
Song Tao - - 2013
Wearable power supplies: Photo-rechargeable devices integrating power conversion and energy storage functions are useful for supplying power to portable electronics. A recent report introduces a facile method to fabricate flexible dual-functional devices on a single metal wire which paves the way for wearable fabric power suppliers.
Liu Bin - - 2013
A 3-phosphonated N-confused phlorin 3 was synthesized by the reaction of N-confused porphyrin 1 and trimethyl- or triethyl phosphite 2 in the presence of acetic acid in good yield. The presence of hydrogen and aryl substituents in one of the meso positions (C5) generates a stereogenic center, resulting in configurationally ...
Lemaire-Vieille Catherine - - 2013
Mutations within the central region of prion protein (PrP) have been shown to be associated with severe neurotoxic activity similar to that observed with Dpl, a PrP-like protein. To further investigate this neurotoxic effect, we generated lines of transgenic (Tg) mice expressing three different chimeric PrP-Dpl proteins. Chi1 (amino acids ...
Alvy Lisa M - - 2013
Childhood abuse and neglect are pervasive problems among girls and young women that have numerous health consequences. Research suggests that sexual minority women are more likely than heterosexual women to report childhood abuse and neglect, but little is known about which sexual minority women are at greatest risk for these ...
Laursen Jonas Striegler - - 2013
Non-natural peptide analogs have significant potential for the development of new materials and pharmacologically active ligands. One such architecture, the β-peptoids (N-alkyl-β-alanines), has found use in a variety of biologically active compounds, but has been sparsely studied with respect to folding propensity. Thus, we here report an investigation of the ...
Vidal Alejandra - - 2013
Diabetic foot ulcers constitute a tremendous challenge for patients, caregivers, and health care systems. The high incidence and high financial costs associated with their treatment have transformed them in a health and economic worldwide problem. The increase in population life expectancy and lifestyle changes have facilitated the spreading of diabetes, ...
Seidner Douglas L - - 2013
Short bowel syndrome-associated intestinal failure (SBS-IF) as a consequence of extensive surgical resection of the gastrointestinal (GI) tract results in a chronic reduction in intestinal absorption. The ensuing malabsorption of a conventional diet with associated diarrhea and weight loss results in a dependency on parenteral nutrition and/or intravenous fluids (PN/IV). ...
Savino Maria Teresa - - 2013
Rai, a Shc adapter family member, acts as a negative regulator of antigen receptor signaling in T and B cells. Rai(-/-) mice develop lupus-like autoimmunity associated to the spontaneous activation of self-reactive lymphocytes. Here, we have addressed the potential role of Rai in the development of the proinflammatory Th1 and ...
Purroy Francisco - - 2013
BACKGROUND: Many guidelines recommend urgent intervention for patients with two or more transient ischaemic attacks (TIAs) within 7 days (multiple TIAs) to reduce the early risk of stroke. OBJECTIVE: To determine whether all patients with multiple TIAs have the same high early risk of stroke. METHODS: Between April 2008 and ...
Melo L Q - - 2013
The effects of rumen digesta volume and pH on VFA absorption and its relation to rumen wall morphology were evaluated. Nine rumen cannulated cows formed three groups based on desired variation in rumen morphology: The High group was formed by Holsteins yielding 25.9 kg Milk/d and fed on a high-grain ...
Shingu Yasushige - - 2013
Background There is currently no standard for the assessment of contractile function in animals. We aimed to determine whether transthoracic echocardiography in rats with chronic pressure overload allows determining the stage of hypertrophy and heart failure (HF).Methods Pressure overload was created by placement of a metal clip around the thoracic aorta at ...
Manouchehri Namdar - - 2013
Background:When asphyxiated neonates require additional cardiovascular support to moderate doses of dopamine infusion, controversy exists on differential hemodynamic effects of two approaches (adding a second inotrope vs. increasing dopamine dosage). We hypothesized that high-dose dopamine (HD) would be detrimental on systemic and regional perfusion when compared with dopamine and epinephrine ...
Kanbay Mehmet - - 2013
Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies have found that uric acid can independently predict the development of hypertension, ...
Muya Jules Tshishimbi - - 2013
Extensive optimisation calculations are performed for the B(80) isomers in order to find out which principles underlie the formation of large hollow boron cages. Our analysis shows that the most stable isomers contain triangular B(10) or rhombohedral B(16) building blocks. The lowest-energy isomer has C(3v) symmetry and is characterised by ...
Kim Young-Cho - - 2013
Associative learning is a fundamental form of behavioral plasticity. Octopamine plays central roles in various learning types in invertebrates; however, the target receptors and underlying mechanisms are poorly understood. Drosophila provides a powerful system to uncover the mechanisms for learning and memory. Here, we report that OAMB in the mushroom ...
Brüser C - - 2013
Reliable and accurate estimation of instantaneous frequencies of physiological rhythms, such as heart rate, is critical for many healthcare applications. Robust estimation is especially challenging when novel unobtrusive sensors are used for continuous health monitoring in uncontrolled environments, because these sensors can create significant amounts of potentially unreliable data. We ...
Ng Michelle M - - 2013
GOLPH3 is a phosphatidylinositol-4-phosphate (PI4P) effector that plays an important role in maintaining Golgi architecture and anterograde trafficking. GOLPH3 does so through its ability to link trans-Golgi membranes to F-actin via its interaction with myosin 18A (MYO18A). GOLPH3 also is known to be an oncogene commonly amplified in human cancers. ...
Giles R L - - 2013
Many estrus synchronization protocols aim to induce a new follicular wave in order to improve response and enhance pregnancy rate. Our objectives were to determine the effectiveness of GnRH analogue administered d 0 and 9 during an extended controlled internal drug release (CIDR) protocol to produce 2 follicular waves, induce ...
Song Liqiang - - 2013
Purpose:This article describes the Self-Expanding Endobronchial Occluder (SEEO) as utilized in Bronchoscopic Lung Volume Reduction (BLVR) with a 36 month follow-up procedure.Methods:23 Patients with severe emphysema were recruited and underwent flexible bronchoscopic placement of the SEEOs. Outcomes were assessed at 1 week, 1-month, 3-, 6-, 12-, 24- and 36-month intervals ...
Shariati S Ali M - - 2013
Expression of amyloid precursor protein (APP) and its two paralogs, APLP1 and APLP2 during brain development coincides with key cellular events such as neuronal differentiation and migration. However, genetic knockout and shRNA studies have led to contradictory conclusions about their role during embryonic brain development. To address this issue, we ...
Flo Elisabeth - - 2013
OBJECTIVES: Shift-related sleep and sleepiness problems may be due to characteristics of both shifts (ie, day, evening and night shifts) and work schedules (ie, permanent vs rotational schedules). The Bergen Shift Work Sleep Questionnaire (BSWSQ) was used to investigate associations between shift-related sleep problems and work schedules. METHODS: 1586 nurses ...
Badreldin Akmal M A - - 2013
There is no universally accepted single line treatment for residual space empyema. Recently, the vacuum-assisted instillation therapy was applied for wounds in different anatomical positions. However, it has not yet been applied as an intrathoracic management. Herein, we describe the first experience of intrathoracic vacuum-assisted instillation therapy for residual space ...
Gately Conor Kennedy - - 2013
On-road transportation is responsible for 28% of all U.S. fossil-fuel CO(2) emissions. Mapping vehicle emissions at regional scales is challenging due to data limitations. Existing emission inventories use spatial proxies such as population and road density to downscale national or state-level data. Such procedures introduce errors where the proxy variables ...
Kosmala Wojciech - - 2013
OBJECTIVES: As myocardial fibrosis might be an important contributor to the association of obesity with left ventricular (LV) dysfunction and heart failure, we investigated the effects of spironolactone on LV function and serological fibrosis markers (procollagen type III N-terminal propeptide (PIIINP) and procollagen type I C-terminal propeptide (PICP)) in patients ...
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