Search Results
Results 551 - 600 of 3451
< 7 8 9 10 11 12 13 14 15 16 17 >
Gustavsson Erik - - 2013
One generally considered plausible way to allocate resources in health care is according to people's needs. In this paper I focus on a somewhat overlooked issue, that is the conceptual structure of health care needs. It is argued that what conceptual understanding of needs one has is decisive in the ...
Okada Muneyoshi - - 2013
Influences of psychotropic drugs, six antipsychotics and three antidepressants, on acetylcholine receptor-operated potassium current (I(K.ACh)) were examined by a whole-cell patch clamp method in freshly isolated guinea-pig atrial myocyte. I(K.ACh) was induced by a superfusion of carbachol (CCh) or by an intracellular application of guanosine 5'-[thio] triphosphate (GTPγS). To elucidate ...
de Girolamo L - - 2013
Low frequency pulsed electromagnetic field (PEMF) has proven to be effective in the modulation of bone and cartilage tissue functional responsiveness, but its effect on tendon tissue and tendon cells (TCs) is still underinvestigated. PEMF treatment (1.5 mT, 75 Hz) was assessed on primary TCs, harvested from semitendinosus and gracilis tendons ...
Little Marc A - - 2013
A new bis(disulfide)-linked offset dimer is formed from a dithiolated analogue of cyclotriguaiacylene. Unlike a similar tris(disulfide)-linked example, this is not a true cryptophane as the offset nature of the dimerisation and intramolecular host-guest interactions preclude its use as a host.
Jun Shin-Hee - - 2013
In this study, a silica xerogel-chitosan hybrid is utilized as a coating material to incorporate bone morphogenic protein-2 (BMP-2) on a porous hydroxyapatite (HA) scaffold for bone tissue engineering. BMP-2 is known as a therapeutic agent for improving bone regeneration and repair. Silica xerogel-chitosan hybrids have been used for the ...
Sotomayor-Zárate Ramón - - 2013
RATIONALE: Neuronal nicotinic acetylcholine receptors (nAChRs) are pharmacological targets that have recently been implicated in the reinforcing effects of many drugs of abuse, including ethanol. Varenicline and cytisine are nAChR partial agonists in clinical use as smoking cessation aids. However, their efficacies to reduce alcohol consumption have not been fully ...
Li Mengyao - - 2013
PURPOSE: To investigate the pharmacological effects of different erlotinib (ER) and gemcitabine (GM) combination schedules by in vitro and in vivo experiments and PK/PD models in non-small cell lung cancer cells. METHODS: H1299 cells were exposed to different ER combined with GM schedules. Cell growth inhibition was analyzed to evaluate ...
Yang Zhen-Yu - - 2013
The Botia superciliaris is endemic to China and distributed mainly in the upper reaches of the Yangtze River. The complete mitochondrial genome was 16,597 bp in length, which contained 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and 1 displacement loop (D-loop) locus. Except for the ND6 gene and eight ...
Ramírez A Susana - - 2013
While many lifestyle-related cancer risk factors including tobacco use, poor diet, and sun exposure are well recognized by the general public, the role of physical activity in decreasing cancer risk is less recognized. Studies have demonstrated gender-, race/ethnicity-, and age-based disparities in cancer risk factor knowledge; however, beliefs and geographic ...
Hamilton-Brehm Scott D - - 2013
A novel sulfate-reducing bacterium designated OPF15(T) was isolated from Obsidian Pool, Yellowstone National Park, Wyoming. The phylogeny of 16S rRNA and functional genes (dsrAB) placed the organism within the family Thermodesulfobacteriaceae. The organism displayed hyperthermophilic temperature requirements for growth with a range of 70-90 °C and an optimum of 83 °C. Optimal ...
Claessen K M J A - - 2013
Arthropathy is an invalidating complication of acromegaly. This arthropathy deteriorates radiographically despite long-term disease control. However, the clinical course and its relationship to the radiographic course are currently unknown. We aimed to investigate the clinical course of arthropathy during follow-up and its relationship to radiographic progression in long-term controlled acromegaly ...
- - 2013
Efforts to extract a Greenland ice core with a complete record of the Eemian interglacial (130,000 to 115,000 years ago) have until now been unsuccessful. The response of the Greenland ice sheet to the warmer-than-present climate of the Eemian has thus remained unclear. Here we present the new North Greenland ...
Vicentini Fabiana Testa Moura de Carvalho - - 2013
With the increasing number of studies proposing new and optimal delivery strategies for the efficacious silencing of gene-related diseases by the local administration of siRNAs, the present review aims to provide a broad overview of the most important and latest developments of non-viral siRNA delivery systems for local administration. Moreover, ...
van Rutte P W J - - 2013
BACKGROUND: With global aging, obesity will increasingly affect the older population with higher risks of morbidity and mortality, yet full consensus has been obtained for the role of sleeve gastrectomy (SG) in the older obese. OBJECTIVE: The aim of this study is to report the outcomes of SG in the ...
Moßhammer Dirk - - 2013
PURPOSE: General practitioners (GPs) and occupational health physicians (OPs) have several overlapping work fields, such as important functions in prevention, rehabilitation and reintegration into the workplace. In Germany, however, cooperation between GP and OP is often lacking or suboptimal. In this article, we analysed the suggestions for optimisation of cooperation. ...
Ottomanelli Lisa - - 2013
PURPOSES: To investigate impact of participation in a supported employment program and impact of employment itself on health-related quality of life (HRQOL), disability, and handicap among Veterans with spinal cord injury (SCI). METHODS: We used a prospective, randomized, controlled, multi-site trial of supported employment (SE) versus treatment as usual (TAU) ...
Springborg Jacob Bertram - - 2013
INTRODUCTION: Hyperthermia is common in brain-injured patients and associated with a worse outcome. As brain rather than body temperature reduction, theoretically, is the most important in cerebral protection, there is logic in targeting cooling at the brain. Selective brain cooling can, in theory, be obtained by cooling the skull or ...
Yamamoto Yoshihiro - - 2013
Healthcare-associated pneumonia (HCAP) may have a more severe course than community-acquired pneumonia (CAP); hence, it is more likely to be caused by drug-resistant bacterial pathogens and anaerobes involved in aspiration pneumonia. We compared the efficacy and safety of initial empiric therapy with piperacillin/tazobactam (PIPC/TAZ, 13.5 g/day) with that of meropenem (MEPM, ...
Sharma Ruchika - - 2013
Malignant rhabdoid tumor (MRT) of the kidney is a rare pediatric tumor characterized by its aggressive nature and chemoresistance. Our patient had MRT of the right kidney with tumor thrombus in the renal vein, inferior vena cava, and right atrium. He developed transfusion-resistant hematuria. This was successfully controlled with right ...
Singmann Henrik - - 2013
We introduce MPTinR, a software package developed for the analysis of multinomial processing tree (MPT) models. MPT models represent a prominent class of cognitive measurement models for categorical data with applications in a wide variety of fields. MPTinR is the first software for the analysis of MPT models in the ...
Bixter Michael T - - 2013
In the present experiments, we explored the relationship between individual differences in working memory (WM) capacity and susceptibility to false recognitions and their accompanying subjective experiences. Deese/Roediger-McDermott (DRM) associative lists were used to elicit false memories, and remember/know judgments were used to measure the recollective experiences accompanying recognition decisions. We ...
Fischer Alyssa - - 2013
Axitinib is a potent, selective vascular endothelial growth factor receptor (VEGFR) inhibitor. We have performed a systematic analysis to investigate the risk of hand-foot skin reaction (HFSR) to axitinib and compare the differences in incidences between sorafenib, sunitinib, pazopanib and axitinib. Relevant studies were identified from PubMed (1998-2012). Eligible studies ...
Dobbie Melissa J - - 2013
Implementing a statistically valid and practical monitoring design for large-scale stream condition monitoring and assessment programs can be difficult due to factors including the likely existence of a diversity of ecosystem types such as ephemeral streams over the sampling domain; limited resources to undertake detailed monitoring surveys and address knowledge ...
Tumonggor Meryanne K - - 2013
Indonesia, an island nation linking mainland Asia with the Pacific world, hosts a wide range of linguistic, ethnic and genetic diversity. Despite the complexity of this cultural environment, genetic studies in Indonesia remain surprisingly sparse. Here, we report mitochondrial DNA (mtDNA) and associated Y-chromosome diversity for the largest cohort of ...
Ratheesh M - - 2013
OBJECTIVE: The present study evaluates the anti-inflammatory effect of the quinoline alkaloid skimmianine (SKM), isolated from Ruta graveolens L., against carrageenan-induced acute inflammation. METHODS: SKM at a dose of 5.0 mg/kg body weight was found to be the minimal concentration for maximal edema inhibition. Carrageenan suspension was administered into the sub-plantar tissue ...
Yoshida Kenji - - 2013
BACKGROUND: When comparing a single-stroke dissection maneuver among surgeons with differing experience levels, there are major differences in the force applied to the instrument tip. It is difficult to explain to surgeons in training the appropriate force and for the surgeons to ascertain the force intuitively. We quantified the force ...
Horie Masanori - - 2013
Abstract The application of carbon nanotube (CNT) as a functional material to engineering and life sciences is advanced. In order to evaluate the cytotoxicity of CNT in vitro, some chemical and biological reagents are used for dispersants. In the present study, the cellular influences of six kinds of chemical or ...
Wang Xinbo - - 2013
The total length of the Bufo tibetanus mitochondrial genome sequence is 17,405 bp. It consists of 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and 1 displacement loop (D-loop). Except for eight tRNAs and nd6 genes, all other mitochondrial genes are encoded on the heavy strand (H strand). Most of ...
Maffiuletti Nicola A - - 2013
The aim of this study was to examine the magnitude and the origin of neuromuscular fatigue induced by half-squat static whole-body vibration (WBV) exercise, and to compare it to a non-WBV condition. Nine healthy volunteers completed two fatiguing protocols (WBV and non-WBV, randomly presented) consisting of five 1-min bouts of ...
Nilsing Emma - - 2013
Purpose The aim of this study was to explore primary healthcare (PHC) professionals' experiences of the sick leave process. Methods This is an explorative study using data from four semi-structured focus group discussions with a purposeful sample of PHC professionals in Östergötland County, Sweden. Content analysis with an inductive approach ...
Hagiwara Keiichi - - 2013
Aquaporins (AQPs), a family of water channel proteins expressed in various cells and tissues, serve as physiological pathways of water and small solute transport. Articular cartilage is avascular tissue with unique biomechanical structure, a major component of which is "water". Our objective is to investigate the immunolocalization and expression pattern ...
Krishnan B - - 2013
Eruption of supernumerary teeth into the nasal cavity is a rare pathological condition. Identification of such teeth is important as they can sometimes cause significant morbidity. This report describes a young female patient with a complaint of epistaxis from the right nasal cavity. The diagnosis of a supernumerary nasal tooth ...
Schluesener Jan K - - 2013
Nanomaterials are a challenge to toxicology. The high diversity of novel materials and products will require extensive expertize for evaluation and regulatory efforts. Nanomaterials are of substantial scientific and economic potential. Here, we will focus on nanosilver, a material not only with medical applications, but a rapidly increasing use in ...
Li Yaping - - 2013
Severe hand, foot, and mouth disease (HFMD) is likely to develop critical complications such as brainstem encephalitis, acute pulmonary edema, and circulatory failure, which cause child mortality during outbreaks. This study aims to investigate factors that predict the severity of HFMD. One hundred sixteen in-patient children with severe HFMD and ...
Kim Sanghee - - 2013
We determined the complete mitochondrial (mt) genome sequence of the red king crab, Paralithodes camtschaticus (Decapoda, Anomura). P. camtschaticus is one of the largest arthropods and the most expensive commercially available gourmet seafood. The genome sequence of P. camtschaticus is 16,720 bp in size and its gene content, gene order, and ...
Marques Alda - - 2013
Abstract Purpose: This study aimed to validate the Activities and Participation component of the Comprehensive International Classification of Functioning, Disability and Health (ICF) Core Set for Obstructive Pulmonary Diseases (OPD) from the patient's perspective. Methods: A cross-sectional qualitative study was conducted with a convenience sample of outpatients with Chronic Obstructive ...
Steca P - - 2013
Numerous empirical studies have investigated the relationships between cardiovascular diseases (CVD) and patients' psychological well-being, with a focus almost exclusively on its dark side. Very little is known on the impact of illness severity on both negative and positive indicators of patients' well-being, as well as on the psychosocial variables ...
Ogawa Ryuichi - - 2013
Heart failure is one of the leading causes of death in developed countries, and its prevalence is expected to increase further in the coming years. While the pharmacokinetic changes observed in patients with heart failure have been reviewed twice in Clinical Pharmacokinetics, approximately a quarter century has passed since the ...
Otunctemur Alper - - 2013
Nephrotoxicity is a major complication of gentamicin (GEN). We aimed to evaluate the potential protective effect of montelukast (MK) against GEN-induced nephrotoxicity in rats. Thirty-two rats were randomly divided into four groups, each consisting of eight animals as follows: (1) the rats were control; (2) intraperitoneally injected with GEN 14 ...
Ganji Masoud Darvish - - 2013
The interaction between oxazepam and C(60) fullerene was explored using first-principles vdW-DF calculations. It was found that oxazepam binds weakly to the fullerene cage via its carbonyl group. The binding of oxazepam to C(60) is affected drastically by nonlocal dispersion interactions, while vdW forces affect the corresponding geometries only a ...
Shtein Liza - - 2013
RATIONALE: Lithium has been a standard pharmacological treatment for bipolar disorder over the last 60 years; however, the molecular targets through which lithium exerts its therapeutic effects are still not defined. Attenuation of the phosphatidylinositol signal transduction pathway as a consequence of inhibition of inositol monophosphatase (IMPase) has been proposed as ...
Yi Nam-Joon - - 2013
BACKGROUND: Currently, no treatment guidelines are available for posttransplant hepatitis B virus (HBV) recurrence. We retrospectively evaluated the rate of clearance of hepatitis B surface antigen (HBsAg) from serum according to various treatment regimens in two large Korean liver transplantation centers. METHODS: Between 1996 and 2008, HBV recurred in 59 ...
Rogić Maja - - 2013
The aim of the present study was to provide normative data for the Croatian language using 346 visually presented objects (Cycowicz, Friedman, Rothstein, & Snodgrass Journal of Experimental Child Psychology 65:171-237, 1997; Roach, Schwartz, Martin, Grewal, & Brecher Clinical Aphasiology 24:121-133, 1996; Snodgrass & Vanderwart Journal of Experimental Psychology: Human ...
Hedrick Philip W - - 2013
Summary With many molecular markers in many species, research efforts in quantitative genetics have focused on dissecting these traits and understanding the importance of factors such as correlated response due to hitchhiking or pleiotropy. Here, in an examination of long-term selection experiments in mice, the evidence strongly supports the primary ...
Bartram Malte P - - 2013
MicroRNAs have emerged as essential regulators of gene expression and may play important roles in a variety of human disorders. To understand the role of microRNA-mediated gene regulation in the kidney, we deleted the microRNA-processing enzyme Dicer in developing renal tubules and parts of the ureteric bud in mice. Genetic ...
Cao Nian - - 2013
Myelination by oligodendrocytes facilitates rapid nerve conduction. Loss of oligodendrocytes and failure of myelination lead to nerve degeneration and numerous demyelinating white matter diseases. N-methyl-D-aspartate (NMDA) receptors, which are key regulators on neuron survival and functions, have been recently identified to express in oligodendrocytes, especially in the myelin sheath. NMDA ...
Owen Shawn C - - 2013
Hydrogels are used to create three-dimensional microenvironments with properties that direct cell function. The current study demonstrates the versatility of hyaluronic acid (HA) based hydrogels with independent control over hydrogel properties such as mechanics, architecture, and spatial distribution of biological factors. Hydrogels were prepared by reacting furan-modified HA with bis-maleimide-poly(ethylene ...
Pierides Chrysoulla - - 2013
Peptides derived from apolipoprotein B (apoB)-100 have been previously used in vaccine preparations to treat atherosclerosis. Such vaccines have been shown to reduce atherosclerotic plaque development by 50 % in experimental animals, and this effect is associated with induction of T helper (Th)2 immune responses. In this study we immunised apolipoprotein ...
Aguayo Víctor M - - 2013
OBJECTIVE: To document the scale-up of India's Adolescent Girls' Anaemia Control Programme following a knowledge-centred framework for scaling up nutrition interventions and to identify the critical elements of and lessons learned from a decade of programme experience for the control of anaemia in adolescent girls. DESIGN: We reviewed all articles, ...
Lo Faso Felice - - 2013
INTRODUCTION: The ideal surgical treatment for pulmonary metastasectomy remains controversial. Minimally invasive surgery may offer advantages for quality of life outcomes, with equivalent oncologic long-term results. The purpose of our study was to confirm the validity of the thoracoscopic approach for pulmonary metastasectomy. METHODS: We retrospectively reviewed 164 patients who ...
< 7 8 9 10 11 12 13 14 15 16 17 >