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Novak Ronald D RD Department of Radiology, School of Medicine, Case Western Reserve University, Cleveland, USA. - - 2013
This study aimed to compare the diagnostic effectiveness of computer-aided detection (CAD) software (OnGuard™ 5.2) in combination with hardware-based bone suppression (dual-energy subtraction radiography (DESR)), software-based bone suppression (SoftView™, version 2.4), and standard posteroanterior images with no bone suppression. A retrospective pilot study compared the diagnostic performance of two commercially ...
Roef Greet L GL Department of Endocrinology, Ghent University Hospital, Ghent, Belgium. - - 2013
Triiodothyronine (T3) has many effects on the heart, and marked changes in cardiac function and structure occur in patients with (subclinical) thyroid disease. We investigated whether between-subject variation in thyroid hormone levels within the euthyroid range is also associated with heart rate and echocardiographic heart function and structure. Subjects were ...
Kirov Ivan I II Department of Radiology, New York University School of Medicine, New York, New York, - - 2013
There are no established biomarkers for mild traumatic brain injury (mTBI), in part because post-concussive symptoms (PCS) are subjective and conventional imaging is typically unremarkable. To test whether diffuse axonal abnormalities quantified with three-dimensional (3D) proton magnetic resonance spectroscopic imaging (¹H-MRSI) correlated with patients' PCS, we retrospectively studied 26 mTBI ...
Sirois Patricia A PA Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA. - - 2013
This study evaluated effects of perinatal exposure to antiretroviral (ARV) medications on neurodevelopment of HIV-exposed, uninfected infants. HIV-exposed, uninfected infants (age 9-15 months) enrolled in Surveillance Monitoring for Antiretroviral Therapy Toxicities, a multisite prospective surveillance study, completed the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III), assessing cognition, language, ...
Campos M Luisa - - 2013
The PTF1 (pancreas transcription factor 1) complex is a master regulator of differentiation of acinar cells, responsible for the production of digestive enzymes. In the adult pancreas, PTF1 contains two pancreas-restricted transcription factors: Ptf1a and Rbpjl. PTF1 recruits P/CAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor] which acetylates Ptf1a and enhances its ...
Sferruzzi-Perri Amanda N AN Department of Physiology, Development and Neuroscience, Centre for Trophoblast Research, University of Cambridge, Cambridge, UK. - - 2013
Size at birth is critical in determining life expectancy with both small and large neonates at risk of shortened life spans. This review examines the hormonal and nutritional drivers of intrauterine growth with emphasis on the role of foetal hormones as nutritional signals in utero. Nutrients drive intrauterine growth by ...
Oglesby-Sherrouse Amanda G AG Department of Pharmaceutical Sciences, School of Pharmacy, Department of Microbiology and Immunology, School of Medicine, University of Maryland Baltimore, 20 Penn Street, Baltimore, MD, USA. - - 2013
For most living organisms, iron is both essential and potentially toxic, making the precise maintenance of iron homeostasis necessary for survival. To manage this paradox, bacteria regulate the acquisition, utilization, and storage of iron in response to its availability. The iron-dependent ferric uptake repressor (Fur) often mediates this iron-responsive regulation ...
Le Jennifer J Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093-0714, USA. - - 2013
: Our objectives were to (1) determine the pharmacokinetic indices of vancomycin in pediatric patients; and (2) compare attainment of 2 target exposures: area under curve (AUC) / minimum inhibitory concentration (MIC) ≥400 and trough concentration ≥15 mcg/mL. : The population-based pharmacokinetic modeling was performed using NONMEM 7.2 for children ...
Janzen Deanna M DM Department of Obstetrics and Gynecology, University of California, Los Angeles, California, - - 2013
Synchronous with massive shifts in reproductive hormones, the uterus and its lining the endometrium expand to accommodate a growing fetus during pregnancy. In the absence of an embryo the endometrium, composed of epithelium and stroma, undergoes numerous hormonally regulated cycles of breakdown and regeneration. The hormonally mediated regenerative capacity of ...
Rochaix Jean-David JD Department of Molecular Biology, University of Geneva, Geneva, Switzerland. - - 2013
Photosynthetic organisms are subjected to frequent changes in their environment that include fluctuations in light quality and quantity, temperature, CO(2) concentration, and nutrient availability. They have evolved complex responses to these changes that allow them to protect themselves against photo-oxidative damage and to optimize their growth under these adverse conditions. ...
Miyoshi Takushi T Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, - - 2013
Actin forms a polarized filament that grows at the barbed end and shrinks at the pointed end. This phenomenon known as "treadmilling" is believed to govern actin filament turnover. However, in the cell, whether actin turnover proceeds by treadmilling or by other reactions, including filament severing, is a debatable issue. ...
Lux Andrew L - - 2013
Infantile spasms remain a challenging condition to study and treat, and although they form the commonest epilepsy syndrome with onset in infancy, the challenge is broadened by the wide range of potential underlying causes. The field of study remains dynamic, with debates relating to case definitions and organising structures for ...
Li Ya-Nan - - 2013
This study investigated the effects of allitridin compound on murine cytomegalovirus (MCMV)-induced regulatory T cell (Treg; CD4(+) CD25(+) Foxp3(+) ) amplification in vivo and in vitro. One hundred twenty MCMV-infected mice were allocated at random into two groups for treatment with allitridin or placebo. Another 120 mock-infected mice were randomly ...
Root Kyle S - - 2013
Multiple noise measurements were taken on 6 types of fire station equipment and 15 types of emergency response vehicle-related equipment used by firefighters during routine and emergency operations at 10 fire stations. Five of the six types of fire station equipment, when measured at a distance of one meter and ear ...
Li Lin - - 2013
Human immunodeficiency virus type 1 (HIV-1) infection by sexual transmission in Guangxi, China had increased dramatically. However, limited information is available on the genetic characterization of the HIV-1 epidemic. In this study, HIV-1 seropositive drug-naïve patients infected by heterosexual transmission were enrolled. The full length gag and pol genes were ...
Becker Joy A - - 2013
Abstract The ranavirus, epizootic hematopoietic necrosis virus (EHNV), is endemic to southern Australia with natural outbreaks resulting in mass mortality events in wild Redfin Perch Perca fluviatilis (also known as Eurasian Perch) and less severe disease in farmed Rainbow Trout Oncorhynchus mykiss. To further investigate the host range for EHNV, ...
Gundogdu Betul M - - 2013
Despite recent advancements in the treatment of coronary artery disease (CAD), it remains the commonest cause of death in the world. Although traditional risk factors partially account for the development of CAD, other novel risk factors have recently been implicated. Specifically, chronic inflammation has been postulated to play a role ...
Cho Kyungmin Jacob - - 2013
This study investigated differences in penetration between fibers and spherical particles through faceseal leakage of an N95 filtering facepiece respirator. Three cyclic breathing flows were generated corresponding to mean inspiratory flow rates (MIF) of 15, 30, and 85 L/min. Fibers had a mean diameter of 1 μm and a median length ...
Su Yingying - - 2013
Hemodialysis patients are at risk for hepatitis C and B virus infections. This study investigated the prevalences and risk factors of HCV and HBV infection and the distribution of HCV genotypes among hemodialysis patients and their spouses. From August to November 2011, a cross-sectional study was conducted on 20 hemodialysis ...
Gronquist David - - 2013
Abstract Fishes in aquaria and aquaculture settings may experience a variety of stressors including crowding, different lighting, periods of food deprivation, and vibrations from sources including pumps and tapping of tank sides. The effects of such low-level chronic stress are poorly explored. We used replicate sets of six Zebrafish Danio ...
Shukla Deepti - - 2013
Enteroviruses have been reported in epidemic form during last 10 years in northern India. Environmental surveillance of sewage is the method of choice in limited resources countries for detection of enterovirus serotypes circulating in the community. Twenty-four sewage samples collected between January, 2009 and December, 2010 were tested for enterovirus ...
Cole Peter A - - 2013
Over the past decade, there has been an increased interest in understanding the operative indications and techniques in treating scapular fractures and tracking their outcomes. Multiple studies have documented poor functional outcomes following nonoperative management of displaced scapular fractures. There is a groundswell of recognition that severe deformity from scapular ...
Koolaee Roodabeh Michelle - - 2013
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of circulating autoantibodies against phospholipid-binding plasma proteins, leading to an increased risk of thrombosis and pregnancy loss. The most common manifestation of lung disease in APS is pulmonary embolism, which may often be the presenting symptom. We present a ...
Farrell David J - - 2013
Irritable bowel syndrome (IBS), a chronic, nonfatal illness is commonly encountered in clinical practice; however, treatment options are limited and often ineffectual. Despite this, there is increasing evidence that bacterial overgrowth in the bowel (dysbiosis) may be an etiological factor in IBS. This has lead to studies in which the ...
Zhou Haiyan H Dubowitz Neuromuscular Centre, Institute of Child Health, University College London, United Kingdom. - - 2013
In the search for the most efficacious antisense oligonucleotides (AOs) aimed at inducing SMN2 exon 7 inclusion, we systematically assessed three AOs, PMO25 (-10, -34), PMO18 (-10, -27), and PMO20 (-10, -29), complementary to the SMN2 intron 7 splicing silencer (ISS-N1). PMO25 was the most efficacious in augmenting exon 7 ...
Montanez-Sauri Sara I SI Materials Science Program, University of Wisconsin-Madison, Madison, WI, - - 2013
During breast carcinoma progression, the three-dimensional (3D) microenvironment is continuously remodeled, and changes in the composition of the extracellular matrix (ECM) occur. High throughput screening platforms have been used to decipher the complexity of the microenvironment and to identify ECM components responsible for cancer progression. However, traditional screening platforms are ...
Graf Erin H EH Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, - - 2013
Integrated HIV DNA can give rise to infectious virus, and therefore may be a surrogate of reservoir size. How this form reflects the amount of replication competent virus in vivo remains to be established. This review highlights the technical hurdles involved in measuring integrated HIV DNA, progress toward overcoming these ...
Shibata Akihiro C E AC Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto, - - 2013
The focal adhesion (FA) is an integrin-based structure built in/on the plasma membrane (PM), linking the extracellular matrix to the actin stress-fibers, working as cell migration scaffolds. Previously, we proposed the archipelago architecture of the FA, in which FA largely consists of fluid membrane, dotted with small islands accumulating FA ...
Porel Mintu M Department of Chemistry, University of Miami, Coral Gables, Florida 33146, - - 2013
A new design strategy is described for chloride ion sensors based on suppression of excited state intramolecular proton transfer in squaramides as a fluorescence "turn on" mechanism.
Menard Cedric C SITI Laboratory, Etablissement Français du Sang Bretagne, CHU Rennes, - - 2013
Clinical-grade mesenchymal stromal cells (MSCs) are usually expanded from bone marrow (BMMSCs) or adipose tissue (ADSCs) using processes mainly differing in the use of fetal calf serum (FCS) or human platelet lysate (PL). We aimed to compare immune modulatory properties of clinical-grade MSCs using a combination of fully standardized in ...
Guan Hanfeng - - 2013
Burkitt lymphoma (BL) is caused by translocation of the MYC gene to an immunoglobulin locus resulting in its constitutive expression depending on the activity of the immunoglobulin (Ig) enhancer elements. Treatment of BL cell lines with epigenetic modifiers is known to repress B-cell-specific genes and to up-regulate B-cell-inappropriate genes including ...
Schleier Jerome J JJ 3rd Department of Land Resources and Environmental Sciences, Montana State University, Bozeman, Montana, USA. - - 2013
The use of pyrethroid insecticides has increased substantially throughout the world over the past few decades as the use of organophorous, carbamate, and organochlorine insecticides is being phased out. Pyrethroids are the most common class of insecticides for ultralow-volume (ULV) aerosol applications used to manage high densities of adult mosquitoes. ...
Mancuso Matthew M Department of Biomedical Engineering, Cornell University, Ithaca, NY, - - 2013
Kaposi's sarcoma (KS) is an infectious cancer occurring most commonly in human immunodeficiency virus (HIV) positive patients and in endemic regions, such as Sub-Saharan Africa, where KS is among the top four most prevalent cancers. The cause of KS is the Kaposi's sarcoma-associated herpesvirus (KSHV, also called HHV-8), an oncogenic ...
Elam W Austin WA T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, - - 2013
Intrinsically disordered (ID) proteins function in the absence of a unique stable structure and appear to challenge the classic structure-function paradigm. The extent to which ID proteins take advantage of subtle conformational biases to perform functions, and whether signals for such mechanism can be identified in proteome-wide studies is not ...
Thomas A C - - 2013
I reflect on the statistical methods of the Christakis-Fowler studies on network-based contagion of traits by checking the sensitivity of these kinds of results to various alternate specifications and generative mechanisms. Despite the honest efforts of all involved, I remain pessimistic about establishing whether binary health outcomes or product adoptions ...
Go Eden P EP Department of Chemistry, University of Kansas, Lawrence, Kansas, United - - 2013
Glycosylation plays an essential role in regulating protein function by modulating biological, structural, and therapeutic properties. However, due to its inherent heterogeneity and diversity, the comprehensive analysis of protein glycosylation remains a challenge. As part of our continuing effort in the analysis of glycosylation profiles of recombinant HIV-1 envelope-based immunogens, ...
Jubran Amal A Division of Pulmonary and Critical Care Medicine, Edward Hines Jr VA Hospital, 111N, 5000 Fifth Ave, Hines, IL 60141, USA. - - 2013
Patients requiring prolonged mechanical ventilation (>21 days) are commonly weaned at long-term acute care hospitals (LTACHs). The most effective method of weaning such patients has not been investigated. To compare weaning duration with pressure support vs unassisted breathing through a tracheostomy collar in patients transferred to an LTACH for weaning ...
VanderWeele Tyler J TJ Department of Epidemiology, Harvard School of Public Health, Boston, MA, U.S.A. - - 2013
States and behaviors of different individuals are expected to be correlated across a social network. Christakis and Fowler have proposed a 'three degrees of influence rule' to characterize the extent of such dependence. In this paper, we discuss three distinct interpretations of such a rule, one involving only associations (which ...
- - 2013
Many approximate accelerated stochastic simulation methods exist that can provide a means of employing Kinetic Monte Carlo techniques to model chemical kinetics. The drawback in using such methods is that sometimes the population of the reactant species present during the simulations becomes negative, leading to unphysical results. This is due ...
- - 2013
The image shows an isosurface of Hirshfeld-I "atoms in molecules" for Ti-doped CeO(2) , taken at an electron density of 0.03e/A(3) , as presented by Danny E. P. Vanpoucke, Patrick Bultinck, and Isabel Van Driessche on page 405. The cubic Ce(0.75) Ti(0.25) O(2) unit cell is shown along the 111 ...
Prochniewicz Ewa - - 2013
We have used time-resolved phosphorescence anisotropy to investigate the effects of essential light chain (ELC) isoforms (A1 and A2) on the interaction of skeletal muscle myosin with actin, to relate structural dynamics to previously reported functional effects. Actin was labeled with a phosphorescent probe at C374, and the myosin head ...
Tsilidis Konstantinos K KK Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom. - - 2013
It has been hypothesized that a high intake of dairy protein may increase prostate cancer risk by increasing the production of insulin-like growth factor 1 (IGF-1). Several single nucleotide polymorphisms (SNPs) have been weakly associated with circulating concentrations of IGF-1 and IGF binding protein 3 (IGFBP-3), but none of these ...
Dong Zhongqi Z Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland , 20 Penn Street, Baltimore, Maryland 21201, - - 2013
The hepatic bile acid uptake transporter sodium taurocholate cotransporting polypeptide (NTCP) is less well characterized than its ileal paralog, the apical sodium dependent bile acid transporter (ASBT), in terms of drug inhibition requirements. The objectives of this study were (a) to identify FDA approved drugs that inhibit human NTCP, (b) ...
Light Samuel H SH Center for Structural Genomics of Infectious Diseases and Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, - - 2013
Dehydroquinate dehydratase (DHQD) catalyzes the third reaction in the biosynthetic shikimate pathway. Type I DHQDs are members of the greater aldolase superfamily, a group of enzymes that contain an active site lysine that forms a Schiff base intermediate. Three residues (Glu86, His143, and Lys170 in the Salmonella enterica DHQD) have ...
Mowrey David D Department of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, - - 2013
The anesthetic propofol inhibits the currents of the homopentameric ligand-gated ion channel GLIC, yet the crystal structure of GLIC with five propofol molecules bound symmetrically shows an open-channel conformation. To address this dilemma and determine if the symmetry of propofol binding sites affects the channel conformational transition, we performed a ...
Velayutham Kanayairam - - 2013
To investigate the larvicidal activity of synthesized silver nanoparticles (Ag NPs) utilizing aqueous bark extract of Ficus racemosa (F. racemosa) was tested against fourth instar larvae of filariasis vector, Culex quinquefasciatus (Cx. quinquefasciatus) and japanese encephalitis vectors, Culex gelidus (Cx. gelidus). The synthesized Ag NPs was characterized by UV-vis spectrum, ...
Perfecto Ivette - - 2013
Competition has been recognized as a major organizing process in ant communities, with ant communities frequently forming spatial mosaics of dominant species associated with subdominants. Often, species exhibit tradeoffs in their ability to discover versus dominate resources, suggesting a mechanism for coexistence. Here we describe spatial patterns of dominant ants ...
Burks Charles S - - 2013
The sampling range of pheromone traps for the navel orangeworm Amyelois transitella (Walker) (Lepidoptera: Pyralidae) and its association with abundance was investigated by examining mutual interference within cross-shaped arrays of nine wing traps baited with virgin females and placed at 400-m intervals in three 256-ha blocks of almonds (Prunus dulcis ...
Warren Jodie-A - - 2013
Experiments were conducted to compare the immature development of Protophormia terraenovae (Robineau-Desvoidy) at fluctuating temperatures of 4-28 and 9-23°C to their mean constant temperature, 16°C. Overall development was fastest at the greater fluctuation and slowest at the constant temperature but showed similar percentages of development time in each stage. The ...
Eltayeb Nagla Mustafa - - 2013
To determine and compare anti-schistosoma IgG, interleukin-10 (IL-10) and interferon-γ(IFN-γ) levels in the serum of patients and endemic controls and to investigate the epidemiological situation of Al-Hebaika village in the northern part of Gezira Agricultural Irrigation Scheme in 2005. During 2005 survey, serum were collected from 118 villagers. Sixty eight ...
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