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S Don - - 2013
Real-time remote health monitoring systems are experiencing tremendous advancement resulting from improvements in low power, reliable sensors; yet they are still constrained to low-level interpretation. Automatic data analysis continues to be a tedious task due to a lack of efficient, reliable platforms for data analysis. In this paper, we present ...
Higgins M J - - 2013
Disease activity in rheumatoid arthritis (RA) is assessed by a combination of objective and subjective tests, combined to produce a disease activity score in 28 joints (DAS28). There is some evidence that RA disease activity, as assessed by DAS28, can be influenced by vitamin D levels. It is difficult to ...
Keceli Ezgi - - 2013
Three highly fluorescent phosphonates have been prepared in good yields from different arylene bridged 5-iodothiophenes by following an optimized four-step procedure. The compounds have been immobilised on mesoporous zirconia, alumina and titania particles in order to probe their luminescence properties on the surfaces. The organic compounds as well as the ...
Li Ka - - 2013
Background/Aims: The incidence of acute pancreatitis has been increasing recently. This study aims to elucidatethe role of TRAIL signal pathway in the process of acute pancreatitis. Methodology: Pancreatitis models were constructed by cerulein or cerulein plus lipopolysaccharide. Amylase and lipidase were measured in different groups. The mRNA expression of TRAIL, ...
Huang Xiao-Bing - - 2013
In our study, we used the GSE17967 series to identify differentially expressed genes between cirrhosis and hepatocellular carcinoma, aiming to analyse the mechanism of the progression of cirrhosis to hepatocellular carcinoma and identify the sub-pathways closely related to this progression, and find the small molecule drugs to interfere this progression. ...
Krajcovic Jozef - - 2013
This report describes an unusual case of a 2.5-month-old infant's sudden death secondary to giant cell myocarditis and endomyocardial calcification, both unusual entities in pediatric patients. The mother had a history of excessive alcohol consumption during pregnancy and the postnatal period. No infectious etiologies, hypersensivity, or autoimmune disorders were identified. ...
Vajen Beate - - 2013
Suv39h1 mediates heterochromatin formation in pericentric and telomeric regions by trimethylation of lysine 9 of histone 3 (H3K9me3). Yet, its role in the induction of chromosomal instability is poorly understood. We established a leukemia model by retrovirally expressing Myc in wild-type and histone methyltransferase Suv39h1-deficient hematopoietic cells and characterized the ...
Feng Pei - - 2013
Objective. To assess whether serum magnesium concentration can predict risk of short-term outcome of acute ischemic stroke. Methods. Between January 1, 2006 and December 31, 2008, 1493 patients with acute ischemic stroke were recruited from four hospitals in Shandong province, P.R China. Data on demographic characteristics, life style risk factors, ...
Qu Lu-Lu - - 2013
A facile one-step approach to fabricate substrates for surface-enhanced Raman scattering (SERS) detection of polycyclic aromatic hydrocarbons (PAHs) was explored by reduction of silver nitrate with humic acids (HAs). This simple process readily delivers silver nanoparticles (Ag NPs) decorated with HAs (HAs-Ag NPs), and an average diameter of 50 nm. ...
Thirumala Sreedhar - - 2013
Mesenchymal stem cells (MSC) and MSC-like cells hold great promise and offer many advantages for developing effective cellular therapeutics. Current trends indicate that the clinical application of MSC will continue to increase markedly. For clinical applications, large numbers of MSC are usually required, ideally in an off-the-shelf format, thus requiring ...
Bashir Rasheeda R School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, - - 2013
The DFNB79 locus harbors TPRN mutations in which have been reported in a few families with deafness. Four frameshift mutations in TPRN have been described to cause severe or severe-to-profound hearing loss in Moroccan and Pakistani families, and a single frameshift mutation was associated with progressive hearing loss in deaf ...
Herouvi Despina - - 2013
In recent years, childhood obesity is becoming an epidemic health problem. It is now evident from many studies that childhood obesity is correlated with adult excess weight status and the development of risk factors for cardiovascular diseases in adulthood, including hypertension, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome. The ...
Kottner Jan - - 2013
Transepidermal water loss (TEWL) is regarded as one of the most important parameters for characterizing skin barrier function but an agreed upon definition of what a "normal" TEWL is does not exist. In order to determine generalizable TEWL values for healthy adults, a systematic review and meta-analysis was conducted. The ...
Kapoor Shailendra S , 74 Crossing Place, Mechanicsville, VA, USA, - - 2013
The recent article by Liu et al. provided for highly interesting reading. Interestingly, recent data suggests that coumarin may exert significant anti-neoplastic effects in a number of systemic malignancies. Coumarin is also of clinical benefit in mammary malignancies. For instance, it attenuates the extent of extremity lymphedema following breast cancer ...
Lusuardi Lukas - - 2013
The most commonly used imaging modalities for diagnostic investigation of bladder carcinoma are contrast-enhanced computed tomography, magnetic resonance imaging, and positron emission tomography. More recently, radioisotope and fluorescence staining are being used before, or even during, open or laparoscopic surgery. We report recent results obtained with these imaging modalities and ...
Yang Sheng-Tao - - 2013
The protein-nanoparticle (NP) interface is a current frontier of multiple disciplines, full of challenges and opportunities. The unique behaviors of nanomaterials (NMs) bring many exciting applications, and also raise safety concerns. Beyond bioapplications, various NMs could also enter human bodies from the environment. When entering human bodies, NPs interact with ...
Moran V - - 2013
The importance of measuring the quality of mental health care is widely recognized. A number of factors should be considered when constructing mental health quality indicators including the aspects of care to be measured; translation of quality measurement concepts into indicators that can be measured; pilot-testing, analysis and display of ...
Hamanaka Ippei - - 2013
Abstract Objective. This study investigated the shear bond strength of an autopolymerizing repair resin to injection-molded thermoplastic denture base resins. Materials and methods. Four injection-molded thermoplastic resins (two polyamides, a polyethylene terephthalate copolymer and a polycarbonate) were used in this study. The specimens were divided into eight groups according to ...
Kumar Arun - - 2013
Suzuki-Miyaura C-C cross coupling (SMC), an important synthetic strategy for many organic molecules, has several advantages such as mild reaction conditions, high tolerance toward various functional groups and ease in isolation of the product. Palladium(ii) ligated with phosphines (particularly bulky and electron-rich) and N-heterocyclic carbenes (NHCs) has been found to ...
Kaasalainen Touko - - 2013
BACKGROUND: CT optimization has a special importance in children. Smaller body size accentuates the importance of patient positioning affecting both radiation dose and image quality. OBJECTIVE: To determine the effect of vertical positioning on organ dose, image noise and contrast in pediatric chest CT examination. MATERIALS AND METHODS: Chest scans ...
Ben-David Haviv - - 2013
Trifluoroethanol was oxidized with O(2) to trifluoroethyl trifluoracetate (>98% selectivity) using Pt(II)(dppz)Cl(2) as a catalyst in the presence of H(2)SO(4); Pt(II)(phen)Cl(2) was inactive. Kinetic isotope effects suggest the C-H bond activation as the rate determining step and DFT calculations showed different frontier orbitals for Pt(II)(dppz) and Pt(II)(phen)-based catalysts.
Kim Mooeung - - 2013
The use of selectivity-enhanced Raman spectra of lube base oil (LBO) samples achieved by the spectral collection under frozen conditions at low temperatures was effective for improving accuracy for the determination of the kinematic viscosity at 40 °C (KV@40). A collection of Raman spectra from samples cooled around -160 °C ...
Sharma Gaurav - - 2013
A significant enhancement in artemisinin content, an important anti-malarial compound, has been achieved in Artemisia annua L. shoots by co-cultivating with Piriformospora indica, a mycorrhiza-like fungus. The in vitro shoots derived from nodal cultures of A. annua were implanted on four different culture media namely, (i) Murashige & Skoog (MS) ...
Hwang Jinyoung - - 2013
A simple strategy for enhancing the Raman spectral selectivity of complex mixture samples by measuring them in a frozen state at low temperatures has been demonstrated and proven to improve the accuracy for compositional analysis. For evaluation, the Raman spectra of synthetic hydrocarbon mixtures that were composed of eleven hydrocarbons ...
Hirabayashi Yu Y Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, - - 2013
The aim of this study was to investigate changes in CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) throughout the clinical course of Kawasaki disease (KD) and correlations with response to intravenous immunoglobulin (IVIg) therapy. Participants comprised 18 patients who fulfilled the diagnostic criteria for KD and 20 healthy subjects. Expressions of CD25 ...
Moerman Rada V - - 2013
Sjögren's syndrome (SS) is a systemic autoimmune disease, characterized by chronic inflammation of exocrine glands that results in development of xerostomia and keratoconjunctivitis sicca. The disease activity of SS is not restricted to exocrine glands, and many other organs and organ systems can be involved. Diagnosis of SS in the ...
Kawachi Yasuhiro - - 2013
Loricrin is a major component of the epidermal cornified cell envelope, and is expressed only in terminally differentiated keratinocytes. This cell differentiation-specific expression pattern suggests specific regulatory mechanisms for activation and suppression of loricrin gene transcription in differentiated keratinocytes. Here, we identified a regulatory element in the proximal promoter region ...
Semenishyn Nikolay - - 2013
Ditopic corroles with lanthanide-binding motifs were prepared and shown to be dual-range emitters, in the visible and near-IR, in ambient conditions.
Mayr Roman - - 2013
Photodynamic Diagnosis (PDD), an adjunct to white light cystoscopy, has been shown to improve detection and thoroughness of resection of bladder cancer by enhancing visualisation of malign lesions during transurethral resection of bladder tumours (TURBT) compared to the sole use of standard white light cystoscopy. The PDD also has been ...
Yeates Keith Owen - - 2013
This study examined peer relationships in children with traumatic brain injury (TBI) relative to children with orthopedic injuries (OI), and explored whether differences in peer relationships correlated with white matter volumes. Classroom procedures were used to elicit peer perceptions of social behavior, acceptance, and friendships for eighty-seven 8- to 13-year-old ...
Jia Fan F Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409-3131, - - 2013
MicroRNAs (miRNAs) are ~21-nucleotide long endogenous small RNAs that regulate gene expression through post-transcriptional or transcriptional gene silencing and/or translational inhibition. miRNAs can arise from the "exon" of a MIRNA gene, from an intron (e.g. mirtrons in animals), or from the antisense strand of a protein coding gene (natural antisense ...
Thiengsusuk Artitaya - - 2013
Malaria is one of the world's leading killer infectious diseases with high incidence and morbidity. The problem of multidrug-resistant Plasmodium falciparum has been aggravating particularly in Southeast Asia. Therefore, development of new potential antimalarial drugs is urgently required. The present study aimed to investigate antimalarial activities of a total of ...
Obanda V - - 2013
SUMMARY Tuberculosis is emerging/re-emerging in captive elephant populations, where it causes morbidity and deaths, although no case of TB in wild African elephants has been reported. In this paper we report the first case of fatal TB in an African elephant in the wild. The infection with Mycobacterium tuberculosis was ...
Halder Amit K - - 2013
Aminopeptidase N (APN) inhibitors have been reported to be effective in treating of life threatening diseases including cancer. Validated ligand- and structure-based pharmacophore mapping approaches were combined with Bayesian modeling and recursive partitioning to identify structural and physicochemical requirements for highly active APN inhibitors. Based on the assumption that ligand- ...
Sitges-Serra A - - 2013
Staged thyroidectomy has been recommended when loss of the signal from intraoperative nerve monitoring is observed after first-side dissection of the recurrent laryngeal nerve. There is no high-quality evidence supporting this recommendation. In addition, it is not clear whether signal loss predicts postoperative vocal cord paralysis. This was a prospective ...
Parton Robert G - - 2013
Caveolae are submicroscopic, plasma membrane pits that are abundant in many mammalian cell types. The past few years have seen a quantum leap in our understanding of the formation, dynamics and functions of these enigmatic structures. Caveolae have now emerged as vital plasma membrane sensors that can respond to plasma ...
Husby Simon - - 2013
Abstract Mantle cell lymphoma (MCL) is rare and aggressive subtype of non-Hodgkin lymphoma. New treatment modalities, including intensive induction regimens with immunochemotherapy and autologous stem cell transplantation, have improved survival, however, many patients still relapse, and there is a need for novel therapeutic strategies. Recent progress has been made in ...
Konno Uta - - 2013
Freshwater aquifers in granitic rocks are widespread microbial habitats in the terrestrial subsurface. Microbial populations in deep granitic groundwater from two recently drilled (1 and 2 years) and two old boreholes (14 and 25 years) were compared. The 16S rRNA gene sequences related to "Candidatus Magnetobacterium bavaricum", Thermodesulfovibrio spp. of Nitrospirae (90.5-93.1 % ...
Craig Dawn - - 2013
The National Institute for Health and Clinical Excellence (NICE) invited the manufacturer of retigabine (GlaxoSmithKline) to submit evidence for the clinical and cost effectiveness of this drug for the treatment of adults with partial-onset seizures in epilepsy, with and without secondary generalization, as part of the Institute's single technology appraisal ...
Uehara Shuichiro - - 2013
The use of thoracoscopy and laparoscopy in the treatment of congenital diaphragmatic hernias (CDHs) has been recently reported; however, the use of these procedures still remains controversial due to CO(2) insufflation and limited working space. In addition, because of difficult techniques, it has not been widely accepted. Among CDH patients, ...
Iwanaga Kazunori - - 2013
Abstract 1. We investigated the effects of the dose of and the number of times an inducer was administered and the duration of induction of hepatic and intestinal cytochrome P450 3A (CYP3A) in rats using dexamethasone 21-phosphate (DEX-P) and midazolam (MDZ) as an inducer and a substrate to CYP3A, respectively. 2. The ...
Volkova V V - - 2013
SUMMARY Enteric commensal bacteria of food animals may serve as a reservoir of genes encoding antimicrobial resistance (AMR). The genes are often plasmidic. Different aspects of bacterial ecology can be targeted by interventions to control plasmid-mediated AMR. The field efficacy of interventions remains unclear. We developed a deterministic mathematical model ...
Zhang Jun - - 2013
Unique nanocomposites of polypyrrole/Au and polypyrrole/Pt hybrid nanotubes are synthesized employing polypyrrole (PPy) nanotubes as an advanced support by solution reduction. The conducting polymer PPy nanotubes are fabricated by using pre-prepared MnO(2) nanowires as the reactive templates. MnO(2) nanowires induce the 1D polymerization of pyrrole monomers and the simultaneous dissolution ...
Maekawa Masahiko - - 2013
The reaction of Cu(ClO(4))·6H(2)O, Cu turnings, and 3,6-bis(2-pyridyl)-1,2,4,5-tetrazine (bptz) in Me(2)CO under C(2)H(4) afforded brownish-red needle crystals of {[Cu(2)(bptz˙(-))(C(2)H(4))(2)](ClO(4))}(2) () as a minor product and brown plate crystals of [Cu(2)(2,5-H(2)bptz)(C(2)H(4))(2)](ClO(4))(2)·2Me(2)CO (). The X-ray crystallographic study showed that complex is composed of two independent [Cu(2)(bptz˙(-))(C(2)H(4))(2)](+) cation moieties and two ClO(4)(-) anions. ...
Hedl M - - 2013
At mucosal surfaces, phagocytes such as macrophages coexist with microbial communities; highly controlled regulation of these interactions is essential for immune homeostasis. Pattern-recognition receptors (PRRs) are critical in recognizing and responding to microbial products, and they are subject to negative regulation through various mechanisms, including downregulation of PRR-activating components or ...
Seto Yasuo - - 2013
A new method for sensitively and selectively detecting chemical warfare agents (CWAs) in air was developed using counter-flow introduction atmospheric pressure chemical ionization mass spectrometry (MS). Four volatile and highly toxic CWAs were examined, including the nerve gases sarin and tabun, and the blister agents mustard gas (HD) and Lewisite ...
Cantley Melissa D - - 2013
Inhibition of histone deacetylases (HDAC) is emerging as a novel approach to treat a variety of diseases. Recently, broad acting inhibitors of HDAC have been shown to have anti-inflammatory effects both in vitro and in vivo. It is significant that these anti-inflammatory effects are observed at 10-100 fold lower concentrations ...
Nilsen Linn Hege LH Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, - - 2013
In neurodegenerative diseases including Alzheimer's disease and frontotemporal dementia, the protein tau is hyperphosphorylated and eventually aggregates to develop neurofibrillary tangles. Here, the consequences of tau hyperphosphorylation on both neuronal and astrocytic metabolism and amino-acid neurotransmitter homeostasis were assessed in transgenic mice expressing the pathogenic mutation P301L in the human ...
Chen Selby S Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. - - 2013
Gliomatosis cerebri is a rare diffusely infiltrating primary neoplastic glial process of the brain. Our objective is to review clinical presentation, management, and outcome in a large single institution series of gliomatosis cerebri patients. 54 consecutive gliomatosis cerebri cases presenting to Mayo Clinic Rochester between 1991 and 2008 were retrospectively ...
Dimitrov B D - - 2013
SUMMARY Data on the dynamics of malaria incidence, admissions and mortality and their best possible description are very important to better forecast and assess the implementation of programmes to register, monitor (e.g. by remote sensing) and control the disease, especially in endemic zones. Semi-annual and seasonal cycles in malaria rates ...
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