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Thaler David E DE Department of Neurology, Tufts Medical Center, Boston, MA 02111, USA. - - 2013
Patent foramen ovale (PFO) and cryptogenic stroke are commonly associated but some PFOs are incidental. Specific radiological findings associated with PFO may be more likely to indicate a PFO-related cause. We examined whether specific radiological findings are associated with PFO among subjects with cryptogenic stroke and known PFO status. We ...
Cornelius Flemming F Department of Biomedicine, University of Aarhus, Ole Worms Allé 6, Building 1180, 8000 Aarhus C 8000, Denmark. - - 2013
The Na,K-ATPase is specifically inhibited by cardiotonic steroids (CTSs) like digoxin and is of significant therapeutic value in the treatment of congestive heart failure and arrhythmia. Recently, new interest has arisen in developing Na,K-ATPase inhibitors as anticancer agents. In the present study, we compare the potency and rate of inhibition ...
Hänsel Robert - - 2013
NMR and fluorescence spectroscopy were used to address the effect of intracellular molecular crowding and re-lated hydration on a model telomeric G-quadruplex (G4) DNA structure (d(AG3(TTAGGG)3)). d(AG3(TTAGGG)3) prevalently adopted the hybrid-1 conformation in vivo, ex vivo, and in dilute potassium-based solution, while it formed the parallel propeller fold in water-depleted ...
Deng Jingjing - - 2013
Direct selective and sensitive sensing of pyrophosphate ion (PPi) in synovial fluid of arthritis patients is of great importance because of its crucial roles in the diagnosis and therapy of arthritic diseases. In this study, we demonstrate a sensitive and selective method for PPi sensing in synovial fluid of arthritis ...
Zeng Caiwen - - 2013
Shenmai injection (SMI) is a popular herbal preparation that is widely used for the treatment of atherosclerotic coronary heart disease and viral myocarditis. In our previous study, SMI was shown to differentially affect CYP3A4-mediated 1'-hydroxylation and 4-hydroxylation of midazolam (MDZ). The present study was conducted to identify the active components ...
Chen I-Wen Peter - - 2013
Handling the (AFM) tip: The duration of stable molecular junctions was prolonged using a tactile feedback method in which the operator can sense the force of the AFM tip on the sample surface. The movement of the tip is adjusted accordingly, maintaining a more consistent current (i) and voltage (V), ...
Heagerty Patrick J PJ Department of Biostatistics, University of Washington, Seattle, Washington 98105-7232, USA. - - 2013
Several statistical approaches for the analysis of longitudinal data require that models be correctly specified for the association between a current outcome and the full history of past outcomes and time-dependent exposures. It is empirically challenging to determine the specific aspects of the outcome and/or exposure history that are predictive ...
Hanson Jesse - - 2013
While antagonists to GluN2B-containing N-Methyl-d-Aspartate receptors (NMDARs) have been widely considered to be neuroprotective under certain pathological conditions, their immediate and lasting impacts on synaptic, circuit, and cognitive functions are poorly understood. In hippocampal slices, we found that the GluN2B-selective antagonist Ro25-6981 (Ro25) reduced synaptic NMDAR responses and consequently neuronal ...
Horak Christine E - - 2013
Background: Predictive biomarkers offer the potential to improve the benefit:risk ratio of a therapeutic agent. Ixabepilone achieves comparable pathologic complete response (pCR) rates to other active drugs in the neoadjuvant setting. This phase II trial was designed to investigate potential biomarkers that differentiate response to this agent. Patients and methods: ...
Murasaki K - - 2013
The whisker pad area (WP) is innervated by the second branch of the trigeminal nerve and experiences allodynia and hyperalgesia following transection of the mental nerve (MN; the third branch of the trigeminal nerve). However, the mechanisms of this extra-territorial pain remain unclear. The ionotropic P2X(7) ATP receptor (P2X(7)) in ...
Cervantes Ruy - - 2013
Two different counter-ion-free host-guest complexes have been prepared and isolated. These compounds were formed from two equally and opposite doubly-charged species, the viologen guests 1 a(2+) and 1 b(2+) and the anti-disulfodibenzo[24]crown-8 [DSDB24C8](2-) host, which gave rise to the 1:1 neutral complexes [1 a⋅DSDB24C8] and [1 b⋅DSDB24C8]. These species are held together by hydrogen ...
Delpozo Juan - - 2013
Gold shuttle: Bulky groups, which will not (or only very sluggishly) undergo Stille coupling with stannanes and inexpensive ligands, can be efficiently coupled using bimetallic catalysis. A gold cocatalyst serves as an efficient shuttle to convey the bulky group from tin to palladium by reducing the steric crowding in the ...
Aper T - - 2013
Introduction: At present the generation of a small-calibre (≤ 5 mm) vascular replacement for artificial bypasses remains a challenge for tissue engineering. The biocompatibility of bioartificial vessel replacements is of decisive significance for function and depends on the materials used. A completely autologous vessel substitute must exhibit high biocompatibility and functionality. For ...
Fujiwara Yusuke - - 2013
Neural encoding and decoding provide perspectives for understanding neural representations of sensory inputs. Recent functional magnetic resonance imaging (fMRI) studies have succeeded in building prediction models for encoding and decoding numerous stimuli by representing a complex stimulus as a combination of simple elements. While arbitrary visual images were reconstructed using ...
León-Novelo Luis G LG Department of Mathematics, University of Louisiana at Lafayette, Lafayette, Louisiana 70504-1010, USA. - - 2013
We discuss inference for a human phage display experiment with three stages. The data are tripeptide counts by tissue and stage. The primary aim of the experiment is to identify ligands that bind with high affinity to a given tissue. We formalize the research question as inference about the monotonicity ...
Xu Zhongjie - - 2013
A high-index topological insulator thin film, Bi(2) Se(3) (221), is grown on a faceted InP(001) substrate by molecular-beam epitaxy (see model in figure (a)). Angle-resolved photoemission spectroscopy measurement reveals the Dirac cone structure of the surface states on such a surface (figure (b)). The Fermi surface is elliptical (figure (c)), ...
Ramallo Virginia - - 2013
Native Americans are characterized by specific and unique patterns of genetic and cultural/linguistic diversities, and this information has been used to understand patterns of geographic dispersion, and the relationship between these peoples. Particularly interesting are the Tupi and Je speaker dispersions. At present, a large number of individuals speak languages ...
Manski Charles F - - 2013
Partial knowledge of patient health status and treatment response is a pervasive concern in medical decision making. Clinical practice guidelines (CPGs) make recommendations intended to optimize patient care, but optimization typically is infeasible with partial knowledge. Decision analysis shows that a clinician's objective, knowledge, and decision criterion should jointly determine ...
Yang Menghua - - 2013
To be successful pathogens, bacteria must often restrict the expression of virulence genes to host environments. This requires a physical or chemical marker of the host environment as well as a cognate bacterial system for sensing the presence of a host to appropriately time the activation of virulence. However, there ...
Krylov Ivan S IS Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United - - 2013
Certain acyclic nucleoside phosphonates (ANPs) such as (S)-HPMPC (cidofovir, Vistide) and (S)-HPMPA have been shown to be active against a broad spectrum of DNA and retroviruses. However, their poor absorption as well as their toxicity limit the utilization of these therapeutics in the clinic. Nucleoside phosphonates are poorly absorbed primarily ...
Nilov Denis Igorevich - - 2013
Oxidation of Adenosine and Inosine: The Chemistry of 8-Oxo-7,8-dihydropurines, Purine Iminoquinones and Purine Quinones as Observed by Ultrafast Spectroscopy. Denis I. Nilov, Dmitry Y. Komarov, Maxim S. Panov, Kanykey E. Karabaeva, Andrey S. Mereshchenko, Alexander N. Tarnovsky* and R. Marshall Wilson* Department of Chemistry and Center for Photochemical Sciences, Bowling ...
Cramer Rainer - - 2013
All charged up: High and prolonged yields of multiply charged peptide and protein ions can be formed in MALDI mass spectrometry using liquid UV-MALDI matrices and a heated ion-transfer tube. The key features are low laser energies of 1-10 µJ, resulting in fluences of less than 200 to 2000 J m(-2) ...
Riede L - - 2013
Abstract Objective: Larch arabinogalactan (ResistAid * ) may prevent cold infections due to its immune-stimulatory properties. In a placebo-controlled, double-blind, randomized clinical trial, the effect of a proprietary larch arabinogalactan preparation on the incidences of common colds and its effect on cold symptoms, as a well established model for immune ...
Zsurka Gábor - - 2013
The classical bioenergetical view of the involvement of mitochondria in neurogeneration is based on the fact that mitochondria are the central players of ATP synthesis in neurons and their failure leads to neuronal dysfunction and eventually to cell death. Mutations in at least 39 genes in inherited neurodegenerative disorders seem ...
Yakushiji Tadayuki - - 2013
Aims: We report the intravascular ultrasound (IVUS) analysis of plaque distribution in left anterior descending (LAD) artery/first diagonal (D1) and distal left main coronary artery (LMCA) bifurcation lesion location. Methods and results: We reviewed 58 angiograms of LAD/D1 bifurcation lesions with pre-intervention IVUS of both the LAD and D1 and ...
Staniczenko Phillip P A - - 2013
Ecologists are fascinated by the prevalence of nestedness in biogeographic and community data, where it is thought to promote biodiversity in mutualistic systems. Traditionally, nestedness has been treated in a binary sense: species and their interactions are either present or absent, neglecting information on abundances and interaction frequencies. Extending nestedness ...
Bada Jeffrey L - - 2013
1953 was a banner year for biological chemistry: The double helix structure of DNA was published by Watson and Crick, Sanger's group announced the first amino acid sequence of a protein (insulin) and the synthesis of key biomolecules using simulated primordial Earth conditions has demonstrated by Miller. Miller's studies in ...
Arnold Tim - - 2013
Nitrogen trifluoride (NF(3)) has potential to make a growing contribution to the Earth's radiative budget; however, our understanding of its atmospheric burden and emission rates has been limited. Based on a revision of our previous calibration and using an expanded set of atmospheric measurements together with an atmospheric model and ...
Parma Paolo - - 2013
Introduction: We present our technique of laparoscopic nephrectomy with intact specimen extraction for patient with autosomal dominant polycystic kidney disease (ADPKD).‚Ä©Materials and Methods: A 5-port retroperitoneal laparoscopic approach was used to dissect the involved kidney, which was then removed intact through a Gibson modified incision.‚Ä©Results: The operative time was 110 ...
Wang Jie - - 2013
AIMS: The anti-cancer anthracycline doxorubicin (DOX) increases the risk of cardiac damage, indicating a need to protect the heart and still allow the benefits of drug treatment. Fibroblast growth factor-2 (FGF-2) is cardioprotective against ischemia-reperfusion injury. Our aim is to investigate: (1) the ability of FGF-2 to protect against DOX-induced ...
Fuchs Ido - - 2013
It is shown that in general, when sub-micron hybrid particles of polymer@silica, are subjected to thermal treatment, phase-separated hydrophobicity emerges at particles surface; and that the triggering of hydrophobicity results in particles which show amphiphilic behavior, arranging themselves at water interfaces and stabilizing W/O and O/W emulsions. Many polymer@silica particles ...
Ciau Nancy - - 2013
Schwannomas arising in the parotid gland or peri-parotid region is frequently misdiagnosed as pleomorphic adenoma on cytologic preparations. The epithelioid variant of schwannoma is particularly susceptible to misdiagnosis because this neoplasm typically has epithelioid and spindled cells, which are associated with fibrillar stroma and mimic the epithelial, myoepithelial, and stromal ...
Yadav J S - - 2013
A novel method has been devised for anti-1,3-aminoalcohols through reductive elimination of iodomethyltetrahydropyrans which are in turn derived from a Prins/Ritter reaction sequence. The synthetic versatility of this method has been explored in the total synthesis of piperidine alkaloids and β-amino acids.
Guevara-Aguirre Jaime - - 2013
Context:The maximum dose of IGF-I recommended for treatment of GH insensitivity is commonly used.Objective:The aim was to test the hypothesis that a lower dose is as effective as a high dose of IGF-I in growth promotion and has fewer deleterious effects.Design and Setting:Subjects were treated for 3 years with regular ...
Vierck Esther - - 2013
Objective:Binocular rivalry refers to a situation where contradictory information is presented simultaneously to the same location of each eye. This leads to the alternation of images every few seconds. The rate of alternation between images has been shown to be slower in euthymic participants with bipolar disorder than in healthy ...
Zhou Jigang - - 2013
Visualization of the state of charge (SOC) in an LiMn(0.75)Fe(0.25)PO(4) nanorods-graphene hybrid nanostructure (LMFP-C) is realized by chemical mapping of the Fe valance state using scanning transmission X-ray microscopy (STXM). The LMFP-graphene interaction strength variation studied by C K-edge STXM has been correlated to SOC variation, i.e. a stronger interaction ...
De Sa Peixoto Paulo P Laboratoire de Chimie de la Matière Condensée de Paris, UMR 7574 Université Pierre et Marie Curie, UPMC/Centre National de La Recherche Scientifique/Collège de France, UPMC, 4 place Jussieu, 75005 Paris, - - 2013
In vivo, collagen I, the major structural protein in human body, is found assembled into fibrils. In the present work, we study a high concentrated collagen sample in its soluble, fibrillar, and denatured states using one and two dimensional {(1)H}-(13)C solid-state NMR spectroscopy. We interpret (13)C chemical shift variations in ...
Sun Hanjun - - 2013
As a rising star in the family of fluorescent material, graphene quantum dots (GQDs) have attracted great attention because of their excellent properties such as high photostability against photobleaching and blinking, biocompatibility and low toxicity. Herein, blue luminescent GQDs were prepared by photo-reducing GQDs with isopropanol. After photochemical reduction, the ...
Buszard Bree J - - 2013
The protein tyrosine phosphatases (PTPs) T cell PTP (TCPTP) and PTP1B share a high level of catalytic domain sequence and structural similarity yet display distinct differences in substrate recognition and function. Their noncatalytic domains contribute to substrate selectivity and function by regulating TCPTP nucleocytoplasmic shuttling and targeting PTP1B to the ...
Sagar Maha M Université de Toulouse, Institut National Polytechnique-Ecole Nationale Supérieure Agronomique de Toulouse, Laboratoire de Génomique et Biotechnologie des Fruits, F-31326 Castanet-Tolosan, - - 2013
Successful completion of fruit developmental programs depends on the interplay between multiple phytohormones. However, besides ethylene, the impact of other hormones on fruit quality traits remains elusive. A previous study has shown that down-regulation of SlARF4, a member of the tomato (Solanum lycopersicum) auxin response factor (ARF) gene family, results ...
Jones Charles H - - 2013
Well-defined cationic polylactides (CPLAs) with tertiary amine groups were synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide to yield polymers with tunable charge densities. CPLAs have not previously been utilized in the context of DNA delivery. Thus, plasmid DNA (pDNA) encoding luciferase was delivered to two physiological distinct cell ...
De Preeti - - 2013
ABSTRACT: BACKGROUND: Smoking is common in people infected with HIV but cessation support is not a routine part of clinical care. The aim was to assess whether smoking is a risk factor for pneumonia in people with HIV and whether smoking cessation ameliorates excess risk. METHODS: We performed MEDLINE and ...
Domaille Dylan W - - 2013
We report the synthesis, characterization, and protein sensing capabilities of M13 bacteriophage-DNA bioconjugates. DNA oligonucleotides were conjugated to M13 through acyl hydrazone linkages. In one case, DNAzymes retained their catalytic ability when anchored to the virus coat, and in a separate study, the dynamic nature of the hydrazone allowed for ...
Okada Hiroshi H Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, - - 2013
Recent study has suggested that not only the presence of hypertension but also the variability in systolic blood pressure (SBP) are risk factors for vascular disease and organ damage. The aim of this study was to investigate the relationship between visit-to-visit variability in SBP and change in urinary albumin excretion ...
Rydberg Patrik - - 2013
Three different types of atom accessibility descriptors are investigated in relation to site of metabolism predictions. To enable the integration of local accessibility we have constructed 2DSASA, a method for the calculation of the atomic solvent accessible surface area that is independent of 3D coordinates. The method was implemented in ...
Tongo Marcel - - 2013
ABSTRACT: BACKGROUND: Cameroon, in west central Africa, has an extraordinary degree of HIV diversity, presenting a major challenge for the development of an effective HIV vaccine. Given the continuing need to closely monitor the emergence of new HIV variants in the country, we analyzed HIV-1 genetic diversity in 59 plasma ...
Gnecco Giorgio - - 2013
Kernel machines traditionally arise from an elegant formulation based on measuring the smoothness of the admissible solutions by the norm in the reproducing kernel Hilbert space (RKHS) generated by the chosen kernel. It was pointed out that they can be formulated in a related functional framework, in which the Green's ...
Terazzi Emmanuel - - 2013
Single molecule magnets may be considered for the construction of future integrated nanodevices, provided however that some degree of ordering is imparted to these molecules (e.g. long-range nano-structuration on surfaces). Combining such magnetic nanometric objects with liquid-crystalline orderings to control their assembly and to potentially address them individually therefore appears ...
González-Garza Maria Teresa MT Cell Therapy Service, Centro de Inovacion y Transferencia en Salud (CITES), Tecnológico de Monterrey, Mexico. - - 2013
Improvements in quality of life and life expectancy have been observed in amyotrophic lateral sclerosis (ALS) patients transplanted with CD133(+) stem cells into their frontal motor cortices. However, questions have emerged about the capacity of cells from these patients to engraft and differentiate into neurons. The objective of this work ...
Oliver Lisa - - 2013
We have recently shown that the in vitro differentiation of human mesenchymal stem cells (hMSCs) was accompanied by an increased sensitivity toward apoptosis; however, the mechanism responsible for this shift is not known. Here, we show that the repair of DNA double-strand breaks (DSBs) was more rapid in undifferentiated hMSCs ...
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