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Mackeen A Dhanya - - 2013
Objective To determine whether 17-α-hydroxyprogesterone caproate (17P) reduces the incidence of preterm birth in women with a history-indicated cerclage.Study Design Retrospective cohort study of women who received a cerclage for a prior preterm birth, analyzed based on exposure to 17P. The primary outcome variable was delivery < 35 weeks. Secondary outcomes were preterm birth < 37, ...
Gyselaers Wilfried - - 2013
Abstract This review summarizes current information on anatomical and physiological properties of the early gestational uteroplacental circulation, and implications of normal or abnormal functioning of the venous compartment. It is illustrated that these properties serve intra-uterine redistribution of blood flow, which is a crucial activity during different stages of trophoblastic ...
Abramson Evan - - 2013
Formation, properties, transformations, and temporal evolution of secondary organic aerosol (SOA) particles depend strongly on SOA phase. Recent experimental evidence from both our group and several others indicates that, in contrast to common models' assumptions, SOA constituents do not form a low-viscosity, well-mixed solution, yielding instead a semisolid phase with ...
Wang Sa - - 2013
Porous materials based on chromium(III) terephthalate metal organic frameworks (MOF) MIL-101(Cr) and their complexes with dialkylaminopyridines (DAAP) were synthesized via a DAAP-MOF complexation, and tested for hydrolytic degradation of organophosphorous esters such as diethyl 4-nitrophenyl phosphate (paraoxon). Elemental analysis, TGA, XRD, FT-IR, TEM, SEM, and nitrogen adsorption measurements indicated that ...
Pradines Vincent - - 2013
On the flip side: A free manganese porphyrin, when activated into a high-valent metal-oxo species, mediates O atom transfer (epoxidation) from both faces. This results in a mixed labeling of epoxide in labeled water. When the porphyrin (blue oval, see scheme) is bound to G-quadruplex DNA (yellow boxes), the O ...
Sivasubramaniyam Tharini - - 2013
Trophoblast cell fusion is a prerequisite for proper human placental development. Herein we examined the contribution of Par6 (Partitioning defective protein 6), a key regulator of cell polarity, to trophoblast cell fusion in human placental development. During early placentation, Par6 localized to nuclei of cytotrophoblast cells but with advancing gestation ...
Bastiaanse Roelien - - 2013
Many studies have shown that verb inflections are difficult to produce for agrammatic aphasic speakers: they are frequently omitted and substituted. The present article gives an overview of our search to understanding why this is the case. The hypothesis is that grammatical morphology referring to the past is selectively impaired ...
Li Qian - - 2013
In order to overcome the difficulty of the original polarizing microscope-based method in monitoring the gelatinization of starch, a new method for dynamically monitoring gelatinization process--integral optical density (IOD) which was based on digital image analysis technique, was proposed. Hot stage light microscopy and DSC technique were coupled to study ...
Munárriz Javier - - 2013
We address new optical nano-antenna systems with tunable highly directional radiation patterns. The antenna comprises a regular linear array of metal nanoparticles in the proximity of an interface with high dielectric contrast. We show that the radiation pattern of the system can be controlled by changing parameters of the excitation, ...
Guo Fen - - 2013
Dermal connective tissue is a supportive structure required for skin's barrier function; dysregulated dermal homeostasis results in chronic wounds and fibrotic diseases. The multifunctional cytokine transforming growth factor (TGF) β promotes connective tissue deposition, repair and fibrosis. TGFβ acts through well-defined canonical pathways; however, the non-canonical pathways through which TGFβ ...
Liang Yeru - - 2013
As an important method for preparing ordered mesoporous polymeric and carbonaceous materials, the organic template directed self-assembly is facing challenges because of the weak non-covalent interactions between the organic templates and the building blocks. Herein we develop a novel reactive template-induced self-assembly procedure for fabrication of ordered mesoporous polymer and ...
Huang Kexuan - - 2013
Rh-catalyzed enantioselective hydrogenation of oxime acetates was first reported, which afforded a new approach for chiral amine synthesis.
Nowacki Jakub - - 2013
The changes in neuronal firing pattern are signatures of brain function, and it is of interest to understand how such changes evolve as a function of neuronal biophysical properties. We address this important problem by the analysis and numerical investigation of a class of mechanistic mathematical models. We focus on ...
Belickova Monika - - 2013
ABSTRACT: BACKGROUND: Interactions between genetic variants and risk factors in myelodysplastic syndromes are poorly understood. In this case--control study, we analyzed 1 421 single nucleotide polymorphisms in 408 genes involved in cancer-related pathways in 198 patients and 292 controls. METHODS: The Illumina SNP Cancer Panel was used for genotyping of ...
Owonikoko Taofeek K TK Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA. - - 2013
Reliable predictive biomarkers are required to address the challenge of disease recurrence after thyroid cancer surgery. For this study, the authors assessed the association of cellular-based and serum-based immunologic mediators with thyroid cancer recurrence. Leukocyte subset counts and immune regulatory cytokine levels were determined in peripheral blood samples using multiparameter ...
Mavridou Despoina A I - - 2013
Cytochromes c are central proteins in energy transduction processes by virtue of their functions in electron transfer in respiration and photosynthesis. They have heme covalently attached to a characteristic CXXCH motif via protein-catalyzed post-translational modification reactions. Several systems with diverse constituent proteins have been identified in different organisms and are ...
Dubuis Julien O - - 2013
Quantification of gene expression has become a central tool for understanding genetic networks. In many systems, the only viable way to measure protein levels is by immunofluorescence, which is notorious for its limited accuracy. Using the early Drosophila embryo as an example, we show that careful identification and control of ...
Wood Jamie R JR Children's Hospital Los Angeles, Los Angeles, California, - - 2013
To assess the proportion of youth with type 1 diabetes under the care of pediatric endocrinologists in the United States meeting targets for HbA1c, blood pressure (BP), BMI, and lipids. Data were evaluated for 13,316 participants in the T1D Exchange clinic registry younger than 20 years old with type 1 ...
Coury Fabienne - - 2013
Bone remodeling requires osteoclasts to generate and maintain an acidified resorption compartment between the apical membrane and the bone surface to solubilize hydroxyapatite crystals within the bone matrix. This acidification process requires (i) apical proton secretion by a vacuolar H(+)-ATPase, (ii) actin cytoskeleton reorganization into a podosome belt that forms ...
Sabbatino Francesco - - 2013
EGFR-specific mAbs display limited therapeutic efficacy in EGFR-positive solid tumors. To overcome this limitation, the significant improvement of the ADCC mediated-anti-tumor activity of a novel EGFR-specific mAb is described. Its potential impact on the efficacy of immunotherapy of EGFR-positive solid tumors is discussed.
Feng Gang - - 2013
The bimolecule acrylic acid-formic acid has been investigated by pulsed jet Fourier transform microwave spectroscopy. The complex adopts two different conformational shapes, according to the cis or trans forms of the acrylic acid moiety. The measurements have been extended to four deuterated and to four (13)C (natural abundance) species, and ...
Tran Stella S Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, - - 2013
Impairments in pituitary FSH synthesis or action cause infertility. However, causes of FSH dysregulation are poorly described, in part because of our incomplete understanding of mechanisms controlling FSH synthesis. Previously, we discovered a critical role for forkhead protein L2 (FOXL2) in activin-stimulated FSH β-subunit (Fshb) transcription in immortalized cells in ...
Bellet Marina M - - 2013
Circadian rhythms govern a wide variety of physiological and metabolic functions in many organisms, from prokaryotes to humans. We previously reported that silent information regulator 1 (SIRT1), a NAD(+)-dependent deacetylase, contributes to circadian control. In addition, SIRT1 activity is regulated in a cyclic manner in virtue of the circadian oscillation ...
Assenza Gabriele Egidy - - 2013
BACKGROUND: VENTRICULAR SEPTAL RUPTURE (VSR) AFTER ACUTE MYOCARDIAL INFARCTION (AMI) IS A POTENTIALLY LETHAL MECHANICAL COMPLICATION OF ACUTE CORONARY SYNDROMES. GIVEN HIGH SURGICAL MORTALITY, TRANSCATHETER CLOSURE HAS EMERGED AS A POTENTIAL STRATEGY IN SELECTED CASES. WE REPORT OUR SINGLE-CENTER EXPERIENCE WITH DOUBLE-UMBRELLA DEVICE PERCUTANEOUS CLOSURE OF POST-AMI VSR.METHODS AND RESULTS: ...
Yamaguchi Kohei - - 2013
We investigated the origin of birefringence in colloidal films of spherical silica particles. Although each particle is optically isotropic in shape, colloidal films formed by drop drying demonstrated birefringence. While periodic particle structures were observed in silica colloidal films, no regular pattern was found in blended films of silica and ...
Osiak M - - 2013
Unique bimodal distributions of single crystal epitaxially grown In(2)O(3) nanodots on silicon are shown to have excellent IR transparency greater than 87% at IR wavelengths up to 4 μm without sacrificing transparency in the visible region. These broadband antireflective nanodot dispersions are grown using a two-step metal deposition and oxidation by ...
Kasemets Kaja - - 2013
ABSTRACT A suite of eight tentatively oxidative stress response-deficient Saccharomyces cerevisiae BY4741 single-gene mutants (sod1Δ, sod2Δ, yap1Δ, cta1Δ, ctt1Δ, gsh1Δ, glr1Δ, ccs1Δ) and one copper-vulnerable mutant (cup2Δ) was used to elucidate weather the toxicity of CuO nanoparticles to S. cerevisiae is mediated by oxidative stress (OS). Specifically, sensitivity profiles of ...
Hu Ye - - 2013
Given the enormous growth of compound activity data we currently observe, we have revisited the previously introduced concepts of privileged substructures and community-selective scaffolds and systematically searched for molecular scaffolds representing compounds active against single targets, multiple targets belonging to the same target family, or targets belonging to different families. ...
Boscher Nicolas D - - 2013
Fluorine-free surfaces with high water contact angle (WCA) and high adhesion force to water are prepared by the atmospheric pressure dielectric barrier discharge (AP-DBD) of hexamethyldisiloxane on cold rolled aluminium foil. Water droplets, which remained on the plasma-polymerized hexamethyldisiloxane (ppHMDSO) surface with contact angle of 155°, do not slide even ...
Varabyova Aksana - - 2013
Mitochondria use 800-1,500 proteins to perform their biological functions in the eukaryotic cells. Distinct transport and sorting mechanisms are responsible for the delivery of proteins to the correct location within mitochondria. Mitochondrial proteins undergo processing events and form functional assemblies. Finally, non-functional proteins are cleared to maintain healthy mitochondria. We ...
Cideciyan Artur V - - 2013
Leber congenital amaurosis (LCA) associated with retinal pigment epithelium-specific protein 65 kDa (RPE65) mutations is a severe hereditary blindness resulting from both dysfunction and degeneration of photoreceptors. Clinical trials with gene augmentation therapy have shown partial reversal of the dysfunction, but the effects on the degeneration are not known. We ...
Chang Jihoon J Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, - - 2013
Myeloid differentiation primary response protein 88 (MyD88) is classically known as an adaptor, linking TLR and IL-1R to downstream signaling pathways in the innate immune system. In addition to its role in innate immune cells, MyD88 has been shown to play an important role in T cells. How MyD88 regulates ...
Wang Yicheng - - 2013
Composition-tunable semiconductor alloy nanowires are emerging as an important class of materials for the realization of high-performance laterally-arranged multiple bandgap (LAMB) solar cells. Here we report the first growth of GaZnSeAs quaternary alloy nanowires with composed elements between two different groups using a temperature/space-selective CVD route. Under laser excitation, these ...
Palagin Dennis - - 2013
Density-functional theory based global geometry optimization is used to scrutinize the possibility of using endohedrally-doped hydrogenated Si clusters as building blocks for constructing highly magnetic materials. In contrast to the known clathrate-type facet-sharing, the clusters exhibit a predisposition to aggregation through double Si-Si bridge bonds. For the prototypical CrSi(20)H(20) cluster ...
Bica Katharina - - 2013
The molar polarisability and molar volume for 71 ionic liquids were extracted from 157 measurements of their refractive index and density, which were then further deconstructed into atomic contributions by means of a Designed Regression analysis. Using this approach, the density and refractive index for any chosen ionic liquid with ...
Vandenberg Cassandra J - - 2013
BH3-only proteins trigger the stress apoptosis pathway and chemical mimetics have great potential for cancer therapy. BH3-only proteins inhibit antiapoptotic members of the Bcl-2 family. Promising BH3 mimetic ABT-737 and the related orally available compound ABT-263 (navitoclax) bind avidly to antiapoptotic Bcl-2, Bcl-xL, and Bcl-w. However, their interaction with Bcl-xL ...
Galzerano Antonio - - 2013
Medullary breast carcinoma (MBC) is a rare epithelial malignancy of the breast accounting for about 1-7% of all breast carcinomas. It is characterized by well-defined borders, a syncytial/solid pattern of growth of high grade atypical cells showing no glandular differentiation and a massive diffuse lympho-plasmacytic peritumoral infiltrate. Despite the high-grade ...
Alexander Bobby - - 2013
Hypothesis. Although several conventional therapeutic options for advanced renal cell carcinoma (RCC) are currently available, the unsatisfactory outcomes demand establishing more effective interventions. D-fraction (PDF), a bioactive proteoglucan of Maitake mushroom, demonstrates anticancer and immunomodulatory activities, which are also shown to be potentiated by vitamin C (VC). We thus hypothesized ...
Zwanenburg Alex - - 2013
Background:The understanding of hypoxemia-induced changes in baroreflex function is limited and may be studied in a fetal sheep experiment before, during, and after standardized hypoxic conditions.Methods:Preterm fetal lambs were instrumented at 102 days gestation (term: 146 days). At 106 days intra-uterine hypoxic-ischemia was induced by 25-min of umbilical cord occlusion ...
Agarwal Vaibhav V Department of Laboratory Medicine, Medical Protein Chemistry, Lund University, Malmö S-205 02, - - 2013
Streptococcus pneumoniae infections remain a major cause of morbidity and mortality worldwide. Therefore a detailed understanding and characterization of the mechanism of host cell colonization and dissemination is critical to gain control over this versatile pathogen. Here we identified a novel 72-kDa pneumococcal protein endopeptidase O (PepO), as a plasminogen- ...
Rodriguez Georgialina G Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas 79902, - - 2013
Cytokine-mediated regulation of T-cell activity involves a complex interplay between key signal transduction pathways. Determining how these signaling pathways cross-talk is essential to understanding T-cell function and dysfunction. In this work, we provide evidence that cross-talk exists between at least two signaling pathways: the Jak3/Stat5 and cAMP-mediated cascades. The adenylate ...
Torricelli Michela - - 2013
Abstract Objective: To evaluate whether maternal weight and BMI and their increase throughout pregnancy are associated with the response to labor induction in postdate pregnancies. Methods: A total of 376 nulliparous women carrying singleton postdate pregnancies with unfavorable cervix were enrolled. We considered as primary outcome vaginal delivery within 24 ...
McConaha Jamie L - - 2013
Objective: To evaluate the financial and clinical outcomes of an over-the-counter (OTC) medication consultation performed by doctorate of pharmacy student pharmacists in a community pharmacy.Design: Cross-sectional survey.Setting: Independent and chain community pharmacy locations in Pittsburgh, Pennsylvania.Participants: Fourth professional year (PY4) advanced experiential student pharmacists on community rotations at the designated ...
Dawson Heidi - - 2013
Dental wear patterns were recorded on 458 deciduous molar teeth, of 142 subadults from late medieval (AD 1086-1539) England, to explore the relationship between dental wear and burial status of children. A new ordinal method for scoring dental wear stages on the deciduous molar teeth was devised. It was postulated ...
Srikhanta Yogitha N - - 2013
AraC-like regulators play a key role in the expression of virulence factors in enteric pathogens, such as enteropathogenic Escherichia coli (EPEC), enterotoxigenic E. coli, enteroaggregative E. coli, and Citrobacter rodentium. Bioinformatic analysis of the genome of rabbit-specific EPEC (REPEC) strain E22 (O103:H2) revealed the presence of a gene encoding an ...
Liistro Francesco F Cardiovascular and Neurologic Department, San Donato Hospital, Arezzo, Italy. - - 2013
Development of critical limb ischemia (CLI) has been reported as an independent predictor of cardiac mortality in diabetic patients. We aimed to determine whether CLI, managed in a structured setting of close collaboration between different vascular specialists and treated with early endovascular intervention, has any impact on long-term cardiac mortality ...
Revicki Dennis A - - 2013
Abstract Objectives: The Psoriasis Symptom Inventory (PSI) is a patient-reported outcome measure for assessing symptom severity in patients with moderate-severe psoriasis. The primary objective of this study was to evaluate the measurement properties of the PSI. Materials and Methods: Analyses of psychometric characteristics (reliability, convergent and known-groups validity, responsiveness, item ...
Flowers Stephen S Department of Orthopaedics, New Jersey Medical School-University Hospital Cancer Center, UMDNJ, Newark, NJ 07103, - - 2013
The retinoblastoma tumor suppressor protein pRB is conventionally regarded as an inhibitor of the E2F family of transcription factors. Conversely, pRB is also recognized as an activator of tissue-specific gene expression along various lineages including osteoblastogenesis. During osteoblast differentiation, pRB directly targets Alpl and Bglap, which encode the major markers ...
Reiter Ronald R Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN 55407, - - 2013
Preinfarction angina may act as a clinical surrogate of ischemic preconditioning that may reduce infarct size and improve mortality in the setting of thrombolytic therapy for ST-elevation myocardial infarction. However, the benefits of preinfarction angina in the setting of primary percutaneous coronary intervention with stenting is inconclusive because of the ...
Bateman Allen C AC Epidemiology Research Center(ML2), Marshfield Clinic Research Foundation, 1000 N Oak Ave, Marshfield, WI 54449, - - 2013
The 2009 influenza A virus subtype H1N1 (A[H1N1]pdm09) did not exhibit antigenic drift during the 2010-2011 influenza season, providing an opportunity to investigate the duration of protection after vaccination. We estimated the independent effects of 2010-2011 seasonal trivalent inactivated influenza vaccine (TIV) and A(H1N1)pdm09 vaccine for preventing medically attended influenza ...
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