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Results 551 - 600 of 2583
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Geiger Carolin - - 2013
ABSTRACT: BACKGROUND: Malaria transmission was reported to have declined in some East African countries. However, a comparable trend has not been confirmed for West Africa. This study aims to assess the dynamics of parasite prevalence and malaria species distribution over time in an area of highly seasonal transmission in Burkina ...
Firczuk Helena - - 2013
Rate control analysis defines the in vivo control map governing yeast protein synthesis and generates an extensively parameterized digital model of the translation pathway. Among other non-intuitive outcomes, translation demonstrates a high degree of functional modularity and comprises a non-stoichiometric combination of proteins manifesting functional convergence on a shared maximal ...
Yu K Y - - 2013
Stacking-fault tetrahedra are detrimental defects in neutron- or proton-irradiated structural metals with face-centered cubic structures. Their removal is very challenging and typically requires annealing at very high temperatures, incorporation of interstitials or interaction with mobile dislocations. Here we present an alternative solution to remove stacking-fault tetrahedra discovered during room temperature, ...
Norikura Toshio - - 2013
We isolated a novel 2',3'-dihydoroxy-p-terphenyl derivatives 2',3'-dihydoroxy-p-terphenyl derivative, thelephantin O (TO), which has cancer-selective cytotoxicity. In this study, we investigated the underlying basis of the cytotoxicity of 2',3'-dihydroxy-p-terphenyl compounds in view of their ability to chelate metal ions. FeCl(2) significantly reduced TO-induced cytotoxicity, while several other salts of transition metals ...
Sugimoto Mikio - - 2013
Objective: To assess the incidence of difficulty in complete dissection between the right adrenal gland and the liver at the time of laparoscopic surgery for adrenal tumor and to elucidate its cause histopathologically. Patients and methods: Thirty six patients underwent laparoscopic right adrenalectomy during the period between 2004 and 2011 ...
Rasappa Sozaraj - - 2013
This paper details the fabrication of ultrathin silicon nanowires (SiNWs) on a silicon-on-insulator (SOI) substrate as an electrode for the electro-oxidation and sensing of ethanol. The nanowire surfaces were prepared by a block copolymer (BCP) nanolithographic technique using low molecular weight symmetric poly(styrene)-block-poly(methyl methacrylate) (PS-b-PMMA) to create a nanopattern which ...
Mithoefer Kai - - 2013
The purpose of this article is to provide an overview and perspective of the available options for clinical outcomes evaluation of articular cartilage repair in the knee. A nonsystematic literature review of reported clinical measures for functional, qualitative, and quantitative structural outcomes evaluation after knee articular cartilage repair was performed. ...
Crystal David - - 2013
This is a report of the main points I made in an informal "conversation" with Paul Fletcher and the audience at the 14th ICPLA conference in Cork. The observations arose randomly, as part of an unstructured 1-h Q&A, so they do not provide a systematic account of the subject, but ...
McIntosh Grant J - - 2013
We have performed the first ab initio study that considers all possible oligomerization reactions available to silicic acid in basic solution (ignoring high-energy multiply charged species), up to and including tetramers. Energies have been computed at the MP2/6-31+G(d)//HF/6-31+G(d) level of theory, with a hybrid solvation model which includes explicit waters ...
Mukherjee Sandip - - 2013
Three new copper-azido complexes [Cu(4)(N(3))(8)(L(1))(2)](n) (), [Cu(4)(N(3))(6)(L(2))(2)(H(2)O)(2)] (), and [Cu(4)(N(3))(6)(L(3))(2)](n) () [L(1) is the imine resulting from the condensation of pyridine-2-carboxaldehyde with N-methylethylenediamine, HL(2) and HL(3) are the condensation products of 2-hydroxy-3-methoxybenzaldehyde with N,N-diethylethylenediamine and N-ethylethylenediamine respectively] have been synthesized by using 0.5 molar equivalents of the Schiff base ligands ...
Ruff Christopher B - - 2013
All early (Pliocene-Early Pleistocene) hominins exhibit some differences in proximal femoral morphology from modern humans, including a long femoral neck and a low neck-shaft angle. In addition, australopiths (Au. afarensis, Au. africanus, Au. boisei, Paranthropus boisei), but not early Homo, have an "anteroposteriorly compressed" femoral neck and a small femoral ...
Bartlett Adrienne J - - 2013
Sulfonamides are a widely used class of antibiotics; however, there are few toxicological data available with which to conduct environmental risk assessments for these compounds. Therefore, the toxicity of four sulfonamides (sulfaguanidine, sulfathiazole, sulfamerazine, and sulfasalazine) to Hyalella azteca was assessed in chronic (four-week), water-only exposures. Survival was evaluated weekly, ...
Lewallen Laura W - - 2013
BACKGROUND:Patellofemoral instability is common in the pediatric and adolescent population, yet prognosis after the first dislocation has been difficult to determine. PURPOSE:To describe the demographics of pediatric and adolescent patients with a first-time patellofemoral dislocation and to determine predictors of recurrent instability. STUDY DESIGN:Case-control study; Level of evidence, 3. METHODS:A ...
Chan Cheong Xin - - 2013
ABSTRACT: : Thanks to advances in next-generation technologies, genome sequences are now being generated at breadth (e.g. across environments) and depth (thousands of closely related strains, individuals or samples) unimaginable only a few years ago. Phylogenomics -- the study of evolutionary relationships based on comparative analysis of genome-scale data -- ...
Li Yuelong - - 2013
An interparticle binding agent, or nanoglue, was synthesized by a sol-gel process, which facilitated the preparation of well-interconnected TiO(2) electrodes at low-temperatures for plastic dye-sensitized solar cells. The viscosity of the nanoglue-based pastes was seven times higher than that obtained in pastes without any nanoglue. The increased viscosity was sufficiently ...
Babak Maria V - - 2013
With the aim of systematically studying fundamental structure-activity relationships as a basis for the development of Ru(II) arene complexes (arene=p-cymene or biphenyl) bearing mono-, bi-, or tridentate am(m)ine ligands as anticancer agents, a series of ammine, ethylenediamine, and diethylenetriamine complexes were prepared by different synthetic routes. Especially the synthesis of ...
Jiang Yan - - 2013
Hollow 0.3Li(2)MnO(3)·0.7LiNi(0.5)Mn(0.5)O(2) microspheres are synthesized on a large scale through a simple in situ template-sacrificial route. Starting from porous MnO(2) microspheres, the hollow microspheres assembled with 0.3Li(2)MnO(3)·0.7LiNi(0.5)Mn(0.5)O(2) nanocrystals are formed by a nanoscale Kirkendall effect. The nanocrystal-assembled hollow 0.3Li(2)MnO(3)·0.7LiNi(0.5)Mn(0.5)O(2) microspheres exhibit a highly reversible capacity as high as 295 mAh ...
Jiang Bin - - 2013
As a powerful tool for biological analysis, especially protein structure and dynamic studies, nuclear magnetic resonance (NMR) spectroscopy suffers from intrinsic low signal to nose ratio (SNR) and long acquisition time required for multidimensional (nD) experiments. Non-uniform sampling (NUS) can effectively speed up the experiment, but often introduces artifacts into ...
Iino Ryota - - 2013
F(o) F(1) -Adenosine triphosphate (ATP) synthase, a complex of two rotary motor proteins, reversibly converts the electrochemical potential of protons across the cell membrane into phosphate transfer potential of ATP to provide the energy currency of the cell. The water-soluble motor is F(1) -ATPase, which possesses ATP synthesis/hydrolysis catalytic sites. ...
Kikuchi Hiromi - - 2013
ABSTRACT: BACKGROUND: To improve quality of life (QOL) in patients with multiple sclerosis (MS), it is important to decrease disability and prevent relapse. The aim of this study was to examine the causal and mutual relationships contributing to QOL in Japanese patients with MS, develop path diagrams, and explore interventions ...
Jiang Liping - - 2013
In the present study, we fabricated an ultrasensitive sandwich-type electrochemical aptasensor for thrombin (TB) based on a triplex signal amplification strategy. The hemin/G-quadruplex horseradish peroxidase-mimicking DNAzyme (HRP-DNAzyme) as well as blocking reagent-horseradish peroxidase (HRP) and iron telluride nanorods (FeTe NRs) could simultaneously amplify the electrochemical signal of thionine (Thi) in ...
Burova Tatiana V - - 2013
Ternary interpolyelectrolyte complexes of insulin with biodegradable synthetic cationic polymer, poly(methylaminophosphazene) hydrochloride (PMAP), and dextran sulfate (DS) were investigated by means of turbidimetry, dynamic light scattering, phase analysis and high-sensitivity differential scanning calorimetry. Formation of ternary insoluble stoichiometric Insulin-PMAP-DS complexes was detected under conditions imitating the human gastric environment (pH ...
Larsen M B - - 2013
A single-blind, randomized, controlled trial was done to compare the results of carpal tunnel release using classic incision, short incision, or endoscopic technique. In total, 90 consecutive cases were included. Follow-up was 24 weeks. We found a significantly shorter sick leave in the endoscopic group. No significant differences in pain, ...
Shimoni R - - 2013
SUMMARY: We describe a modular MATLAB® Toolbox named TACTICS for time lapse image analysis that meets several requirements not generally offered by currently available software packages: (i) the ability to assess quality of extracted imaging information by directly linking data endpoints to the original position, (ii) massively parallel analysis of ...
Zhang Li - - 2013
Five new complexes [Zn(HL(1))(OAc)(CH(3)CH(2)OH)] (), [Cd(2)(HL(1))(2)(OAc)(2)(CH(3)CH(2)OH)(2)] (), [Cu(6)(L(1))(6)] () (H(2)L(1) = N-(1-phenyl-3-phenmethyl-4-phenylethylene-pyrazolone-5)-salicylidene hydrazide, OAc = acetate anion), {[Zn(L(2))(CH(3)OH)]·(CH(3)OH)}(n) () (H(2)L(2) = N-(1-phenyl-3-phenmethyl-4-ethylene-pyrazolone-5)-salicylidene hydrazine), [Cu(L(3))](n) () (H(2)L(3) = N-(1-phenyl-3-phenmethyl-4-benzylidene-pyrazolone-5)-salicylidene hydrazide) have been synthesized and characterized by chemical and spectroscopic techniques. Complexes feature mononuclear, dinuclear and rare hexanuclear structures, respectively. The different ...
Tseng Hung-Yu - - 2013
The on-substrate fabrication of a bio-conjugated Au nanoring (NRI) solution with the localized surface plasmon (LSP) resonance wavelength in the 1200-1300 nm range is demonstrated. Also, the effects of photothermal therapy through LSP resonance-induced absorption enhancement are illustrated by applying the bio-conjugated Au NRIs to human liver cancer cells and illuminating ...
Silva Augusta - - 2013
Introduction. Sit-to-stand (SitTS) and stand-to-sit (StandTS) are very important functional tasks that become compromised in stroke patients. As in other voluntary movements, they require an adequate postural control (PC) involving the generation of anticipatory postural adjustments (APAs). In order to give clues for more efficient and directed rehabilitation programs, a ...
Reznichenko Anna - - 2013
Genome-wide association studies reported SLC22A2 variants to be associated with serum creatinine. As SLC22A2 encodes the organic cation transporter 2 (OCT2), the association might be due to an effect on tubular creatinine handling. To test this hypothesis we studied the association of SLC22A2 polymorphisms with phenotypes of net tubular creatinine ...
Ruotsalainen Anna-Kaisa - - 2013
AIMS: The loss of Nrf2 has been shown to protect against atherogenesis in apoE-deficient mice. The mechanism by which Nrf2 deficiency affords atheroprotection in this model is currently unknown, but combined systemic and local vascular effects on lesion macrophages have been proposed. We investigated the effect of bone marrow specific ...
Ando Hirohiko - - 2013
AIMS: The pathogenesis of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation remains unclear. The purpose of this study is to analyse tissue characterizations of neointima in restenosis lesions after sirolimus-eluting stent (SES), comparing with those after bare metal stent (BMS) using integrated backscatter intravascular ultrasound (IB-IVUS). METHODS AND RESULTS: ...
Ou Horng-Yih - - 2013
Activation of G protein-coupled receptor 40 (GPR40) by agonists increases insulin release in isolated islets, whereas it is inconclusive as to whether GPR40 antagonists decrease blood glucose and increases insulin sensitivity. Although some clinical trials indicated that administration of a GPR40 agonist shows benefits in the regulation of blood glucose ...
Liao Rijing - - 2013
Histones participate in transcriptional regulation via a variety of dynamic posttranslational modifications (PTMs) on them. Mass spectrometry (MS) has become a powerful tool to investigate histone PTMs. With the Bottom-up mass spectrometry approach, chemical derivatization of histones with propionic anhydride or deuterated acetic anhydride followed by trypsin digestion was widely ...
Chaudhary Shweta - - 2013
Isolated spinal leptomeningeal metastases (LMM) without brain metastases are infrequent, accounting for about 1% of all solid tumors. In LMM, cerebrospinal fluid (CSF) analyses are mostly abnormal. Demonstrations of intrathecal tumor markers are highly suggestive, but only a positive cytology is diagnostic. The initial CSF cytology can give a false ...
Hariharan Srirama - - 2013
Identifying dual role electrode materials capable of storing both lithium and sodium are thought to be highly relevant, as these materials could find potential applications simultaneously in lithium and sodium ion batteries. In this regard, the concept of dual alkali storage is demonstrated in Fe(3)O(4) anode material undergoing conversion reaction. ...
Latimer Nicholas R - - 2013
BACKGROUND: In health technology assessments (HTAs) of interventions that affect survival, it is essential to accurately estimate the survival benefit associated with the new treatment. Generally, trial data must be extrapolated, and many models are available for this purpose. The choice of extrapolation model is critical because different models can ...
Dau Phuong V - - 2013
The synthesis and physical properties of dioxole functionalized metal-organic frameworks (MOFs) are reported. Combination of benzo[d][1,3]dioxole-4,7-dicarboxylic acid (dioxole-BDC) and Zn(ii) under solvothermal conditions yields either an isoreticular metal-organic framework analog (IRMOF-1-dioxole) or a new MOF material (MOF-1-dioxole). With the addition of a co-ligand, namely 4,4'-bipyridine, a mixed-linker Zn(ii)-paddlewheel MOF (BMOF-2-dioxole) ...
Zollner Barbara - - 2013
Aim: The aim of the project Pharmacases.de was to develop an innovative concept for creating high-quality e-learning content which integrates and promotes the theoretical and cooperative skills of final-year medical students and is easily adoptable by cooperating institutes and hospitals. Methods and results: A peer-teaching concept was developed in which ...
McConaha Jamie L - - 2013
Objective: To evaluate the financial and clinical outcomes of an over-the-counter (OTC) medication consultation performed by doctorate of pharmacy student pharmacists in a community pharmacy.Design: Cross-sectional survey.Setting: Independent and chain community pharmacy locations in Pittsburgh, Pennsylvania.Participants: Fourth professional year (PY4) advanced experiential student pharmacists on community rotations at the designated ...
Dawson Heidi - - 2013
Dental wear patterns were recorded on 458 deciduous molar teeth, of 142 subadults from late medieval (AD 1086-1539) England, to explore the relationship between dental wear and burial status of children. A new ordinal method for scoring dental wear stages on the deciduous molar teeth was devised. It was postulated ...
Revicki Dennis A - - 2013
Abstract Objectives: The Psoriasis Symptom Inventory (PSI) is a patient-reported outcome measure for assessing symptom severity in patients with moderate-severe psoriasis. The primary objective of this study was to evaluate the measurement properties of the PSI. Materials and Methods: Analyses of psychometric characteristics (reliability, convergent and known-groups validity, responsiveness, item ...
Hänsel Robert - - 2013
NMR and fluorescence spectroscopy were used to address the effect of intracellular molecular crowding and re-lated hydration on a model telomeric G-quadruplex (G4) DNA structure (d(AG3(TTAGGG)3)). d(AG3(TTAGGG)3) prevalently adopted the hybrid-1 conformation in vivo, ex vivo, and in dilute potassium-based solution, while it formed the parallel propeller fold in water-depleted ...
Deng Jingjing - - 2013
Direct selective and sensitive sensing of pyrophosphate ion (PPi) in synovial fluid of arthritis patients is of great importance because of its crucial roles in the diagnosis and therapy of arthritic diseases. In this study, we demonstrate a sensitive and selective method for PPi sensing in synovial fluid of arthritis ...
Zeng Caiwen - - 2013
Shenmai injection (SMI) is a popular herbal preparation that is widely used for the treatment of atherosclerotic coronary heart disease and viral myocarditis. In our previous study, SMI was shown to differentially affect CYP3A4-mediated 1'-hydroxylation and 4-hydroxylation of midazolam (MDZ). The present study was conducted to identify the active components ...
Chen I-Wen Peter - - 2013
Handling the (AFM) tip: The duration of stable molecular junctions was prolonged using a tactile feedback method in which the operator can sense the force of the AFM tip on the sample surface. The movement of the tip is adjusted accordingly, maintaining a more consistent current (i) and voltage (V), ...
Li Han - - 2013
ABSTRACT: BACKGROUND: The modern society primarily relies on petroleum and natural gas for the production of fuels and chemicals. One of the major commodity chemicals 1,2-propanediol (1,2-PDO), which has an annual production of more than 0.5 million tons in the United States, is currently produced by chemical processes from petroleum ...
Inoue Koichi - - 2013
The presence of specific volatile and aminothiols in wine is associated with quality, worth, price and taste. The identification of specific thiol-containing compounds in various wines has been reported in many valuable and interesting works. In this study, a novel foodomics assay of thiol-containing compounds, such as free aminothiols and ...
Patterson Z R - - 2013
Chronic stressors promote metabolic disturbances, including obesity and metabolic syndrome. Ghrelin, a peptide that promotes appetite and the accumulation of adipose tissue, is also secreted in response to stressors to protect the brain and peripheral tissues from the effects of these stressors. Here we demonstrate that elevated ghrelin levels produced ...
Zhang Qiao Bao - - 2013
Reversible superhydrophobic and superhydrophilic surfaces based on porous substrates covered with CuO nanowires are developed in this study. A facile thermal oxidation method is used to synthesize non-flaking bicrystalline CuO nanowires on porous copper substrates in static air. The effects of thermal oxidation temperature and duration are systemically studied. The ...
Gibbon Fiona E - - 2013
Profiling Elements of Prosody in Speech-Communication (PEPS-C) has not been used widely to assess prosodic abilities of preschool children. This study was therefore aimed at investigating typically developing 4-year-olds' performance on PEPS-C. PEPS-C was presented to 30 typically developing 4-year-olds recruited in southern Ireland. Children were judged to have completed ...
Wimer David J - - 2013
The present study examined whether previous findings linking masculinity constructs and health behaviors applied to a relatively recent health risk behavior for men, the consumption of energy drinks. In addition, it also examined whether self-identifying as a jock and being a member of a fraternity would moderate the relationships between ...
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