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Wei Dacheng - - 2013
Graphene is often regarded as one of the most promising candidates for future nanoelectronics. As an indispensable component in graphene-based electronics, the formation of junctions with other materials not only provides utility functions and reliable connexions, but can also improve or alter the properties of pristine graphene, opening up possibilities ...
Haklar Ugur - - 2013
BACKGROUND:Although numerous studies have assessed arthroscopic repair of meniscal tears, no study has described the repair of partial- or full-thickness longitudinal medial meniscal tears using single or double vertical sutures. PURPOSE:To present the intermediate-term results of medial meniscal tears repaired with single or double vertical sutures. STUDY DESIGN:Case series; Level ...
Adén Jörgen - - 2013
Enzymatic activity is ultimately defined by the structure, chemistry and dynamics of the Michaelis complex. There exist a large number of experimentally determined structures between enzymes and substrates or substrate analogues or inhibitors. However, transient, short-lived encounter and equilibrium structures also play fundamental roles during enzymatic reaction cycles. Such structures ...
van Honk Jack - - 2013
Contemporary economic models hold that instrumental and impulsive behaviors underlie human social decision making. The amygdala is assumed to be involved in social-economic behavior, but its role in human behavior is poorly understood. Rodent research suggests that the basolateral amygdala (BLA) subserves instrumental behaviors and regulates the central-medial amygdala, which ...
Sit Patrick H-L - - 2013
Certain bacterial enzymes, the diiron hydrogenases, have turnover numbers for hydrogen production from water as large as 10(4)/s. Their much smaller common active site, composed of earth-abundant materials, has a structure that is an attractive starting point for the design of a practical catalyst for electrocatalytic or solar photocatalytic hydrogen ...
Parma Paolo - - 2013
Introduction: Enterovesical fistula (EVF) is an abnormal communication between the intestine and the bladder. We present the case of EVF secondary to diverticular disease in a male with congenital megaureter. A laparoscopic repair of the colon vesical fistula was performed with colon resection.
Materials and Methods: With the patient in the ...
Wettwer Erich - - 2013
AIMS: Vernakalant is a newly developed antiarrhythmic drug against atrial fibrillation. However, its electrophysiological actions on human myocardium are unknown. METHODS: Action potentials and ion currents were recorded in right atrial trabeculae and cardiomyocytes from patients in sinus rhythm (SR) and chronic atrial fibrillation (AF). RESULTS: Vernakalant prolonged early repolarization ...
Dong Liang - - 2013
The native copper adatoms get trapped in a self-assembled molecular nanostructure which is mainly formed by the intermolecular van der Waals interactions, and two dominating specific binding modes between the adatoms and the molecules are revealed at the atomic scale by high-resolution STM imaging.
Nickol Devin - - 2013
Abstract Protozoans of the family Opalinidae are intestinal commensals in amphibians. To test the hypothesis that these organisms are susceptible to the antiprotozoal antibiotic metronidazole, we randomly assigned 60 juvenile Woodhouse toads (Bufo woodhousii) to receive a single oral dose of metronidazole or water. In pilot trials, the prevalence of ...
Zhao Yi - - 2013
The skin is exposed to environmental insults such as ultraviolet light which cause oxidative damage to macromolecules. A centerpiece in the defense against oxidative stress is the Nrf2 (Nuclear factor (erythroid-derived-2)-like 2)-mediated transcriptional up-regulation of antioxidant and detoxifying enzymes and the removal of oxidatively damaged material. Autophagy plays an important ...
Corry June - - 2013
A 53-year-old man presented with a 6-month history of mild hoarseness, with no associated pain, dysphagia, or stridor. At nasoendoscopy, a lesion was detected involving the whole length of the left vocal cord, with abnormal mucosa also seen in the right ventricle (Fig 1). The left vocal cord movement was ...
Signore Giovanni - - 2013
A fluorescent probe structurally similar to the GFP chromophore is demonstrated to report the local static dielectric constant. This probe can be chemically functionalized for selective targeting at the intracellular level.
Hsu Tienyi Theresa - - 2013
3-Hydroxybutyric acid (also referred to as beta-hydroxybutyric acid or BHB), a small molecule metabolite whose concentration is elevated in Type I diabetes and diabetic coma, was found to modulate the properties of DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) monolayers when added to the subphase at clinical concentrations. This is a key piece of evidence ...
Lepage Kyle Q KQ Department of Mathematics, Boston University, Boston, MA 02446, USA. - - 2013
The instantaneous phase of neural rhythms is important to many neuroscience-related studies. In this letter, we show that the statistical sampling properties of three instantaneous phase estimators commonly employed to analyze neuroscience data share common features, allowing an analytical investigation into their behavior. These three phase estimators-the Hilbert, complex Morlet, ...
Schouten Henrike J - - 2013
Venous thrombo-embolism (VTE, pulmonary embolism and deep vein thrombosis) is common in the elderly and short-term mortality risk increases with age. Hence, notably in older patients, accurately diagnosing VTE can be lifesaving. However, most clinically suspected individuals turn out to have no VTE after imaging examination. Therefore, many physicians would ...
Williams Hywel T P - - 2013
ABSTRACT: BACKGROUND: Bacteriophage (viruses that infect bacteria) are of key importance in ecological processes at scalesfrom biofilms to biogeochemical cycles. Close interaction can lead to antagonistic coevolution ofphage and their hosts. Selection pressures imposed by phage are often frequency-dependent, suchthat rare phenotypes are favoured; this occurs when infection depends on ...
Rietveld Ivo B - - 2013
EMLA® cream, a "eutectic mixture of local anesthetics", was developed in the early 1980s by Astra Pharmaceutical Production. Although it has been clear from the beginning that the eutectic between prilocaine and lidocaine played a role in the anesthetic mixture, which is liquid at room temperature, the thermodynamic reasons behind ...
Xu Xin-Xin - - 2013
To improve the photocatalytic activity of a coordination polymer in the visible light region, polyaniline (PANI) was loaded onto its surface through a facile in situ chemical oxidation polymerization process. The resulting PANI loaded coordination polymer composite materials with excellent stability exhibit significantly higher photocatalytic activities than the pure coordination ...
Mazin Pavel - - 2013
While splicing differences between tissues, sexes and species are well documented, little is known about the extent and the nature of splicing changes that take place during human or mammalian development and aging. Here, using high-throughput transcriptome sequencing, we have characterized splicing changes that take place during whole human lifespan ...
Maekawa Fumihiko - - 2013
Sexual differentiation leads to structural and behavioural differences between males and females. Here we investigate the intrinsic sex identity of the brain by constructing chicken chimeras in which the brain primordium is switched between male and female identities before gonadal development. We find that the female chimeras with male brains ...
Belote John M - - 2013
Post-copulatory sexual selection arises when females mate with multiple males, resulting in competition between ejaculates to fertilize the female's eggs. Such selection is recognized as an important engine of evolutionary diversification and speciation, yet the mechanisms underlying sperm competition are poorly known due to dual challenges of observing events within ...
Kleinke Andrew S - - 2013
The first continuous hydrogenation that requires neither H(2) nor metal catalysis generates diimide by a novel reagent combination. The simple flow reactor employed minimizes residence time by enabling safe operation at elevated temperature.
Gibiansky Maxsim L - - 2013
Myxococcus xanthus is a bacterium capable of complex social organization. Its characteristic social ("S")-motility mechanism is mediated by type IV pili (TFP), linear actuator appendages that propel the bacterium along a surface. TFP are known to bind to secreted exopolysaccharides (EPS), but it is unclear how M. xanthus manages to ...
Tolppanen Anna-Maija AM Institute of Clinical Medicine, Neurology, University of Kuopio, Kuopio, Finland. - - 2013
Type 2 diabetes in midlife or late life increases the risk of Alzheimer disease (AD), and type 1 diabetes has been associated with a higher risk of detrimental cognitive outcomes, although studies from older adults are lacking. We investigated whether individuals with AD were more likely to have a history ...
Holloway Kimberly R KR Departments of Molecular and Cellular Physiology, Louisiana State University Health, Sciences Center School of Medicine in Shreveport, Shreveport, LA 71130, - - 2013
Breast cancer remains one of the leading causes of death in women diagnosed with cancer. In breast cancer, aberrant expression of the CYP19A1 gene, which encodes the aromatase enzyme, contributes to increased intratumoral levels of estradiol. Regardless of whether this estrogen is produced by peripheral tissues or within specific subpopulations ...
Simonsen Hanne Gram - - 2013
In this article, we present a study of imageability ratings for a set of 1599 Norwegian words (896 nouns, 483 verbs and 220 adjectives) from a web-based survey. To a large extent, the results are in accordance with previous studies of other languages: high imageability scores in general, higher imageability ...
Li Feng - - 2013
Density functional theory calculations and first-principles molecular dynamics (MD) simulations have been performed to examine the strain effect on the colossal oxygen ionic conductivity in selected sandwich structures of zirconia electrolytes. For the KTaO(3)/YSZ/KTaO(3) sandwich structure with 9.7% lattice mismatch, transition state calculations indicate that the strain effect changes the ...
Bu Hang-Beom - - 2013
Water soluble nanoparticles (NPs) with a high emission property were synthesized via hydrothermal routes. In this report, we chose thiol ligand N-acetyl-l-cysteine as the ideal stabilizer and have successfully employed it to synthesize readily size-controllable CdTe NPs in a reaction of only one step. Hydrothermal synthesis of CdTe NPs has ...
Michalak Krzysztof W - - 2013
OBJECTIVES: Neoaortic root changes in children with transposition of the great arteries (TGA) are reportedly risk factors for the development of neoaortic regurgitation (NeoAR). The aims of this study were to assess the neoaortic root diameter and relative proportion in children with TGA after surgical correction and to identify possible ...
Liu Yi-Tao - - 2013
We report a universal strategy for the hierarchical assembly of nanoparticles on various 2D materials, resulting in functional 0/2D nanohybrids holding great promise in catalysis, energy storage, and chemical and biological sensing.
Shibuya Norihiro - - 2013
In eukaryotes, hydrogen sulphide acts as a signalling molecule and cytoprotectant. Hydrogen sulphide is known to be produced from L-cysteine by cystathionine β-synthase, cystathionine γ-lyase and 3-mercaptopyruvate sulfurtransferase coupled with cysteine aminotransferase. Here we report an additional biosynthetic pathway for the production of hydrogen sulphide from D-cysteine involving 3-mercaptopyruvate sulfurtransferase ...
Davydov Iakov I - - 2013
The emergence of ribosomes and translation factors is central for understanding the origin of life. Recruitment of translation factors to bacterial ribosomes is mediated by the L12 stalk composed of protein L10 and several copies of protein L12, the only multi-copy protein of the ribosome. Here we predict stoichiometries of ...
Eichinger Christian S CS Department of Biochemistry, University of Oxford, Oxford, - - 2013
Cohesin's Smc1, Smc3, and kleisin subunits create a tripartite ring within which sister DNAs are entrapped. Evidence suggests that DNA enters through a gate created by transient dissociation of the Smc1/3 interface. Release at the onset of anaphase is triggered by proteolytic cleavage of kleisin. Less well understood is the ...
Lin Shiyun - - 2013
We demonstrate a reusable and reconfigurable SERS platform by optically trapping Ag nanoparticles with a photonic crystal cavity integrated with a microfluidic chip. High performance SERS is performed in a very reproducible manner, owing to the fact that Ag aggregates are produced by optical trapping in a controllable process that ...
Zimmerman Eric I EI Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, - - 2013
Many tyrosine kinase inhibitors (TKI) undergo extensive hepatic metabolism, but mechanisms of their hepatocellular uptake remain poorly understood. We hypothesized that liver uptake of TKIs is mediated by the solute carriers OATP1B1 and OATP1B3. Transport of crizotinib, dasatinib, gefitinib, imatinib, nilotinib, pazopanib, sorafenib, sunitinib, vandetanib, and vemurafenib was studied in ...
Granstam Sven-Olof - - 2013
To characterize patients with cardiac amyloidosis using echocardiography, electrocardiogram (ECG) and right heart catheterization (RHC). Fourteen patients with biopsy verified light chain or transthyretin cardiac amyloidosis were included. All patients had heart failure with markedly elevated NT-proBNP. Echocardiography demonstrated biventricular hypertrophy, left atrial enlargement and normal to slightly reduced left ...
Goubau J F - - 2013
De Quervain's disease has different clinical features. Different tests have been described in the past, the most popular test being the Eichhoff's test, often wrongly named as the Finkelstein's test. Over the years, a misinterpretation has occurred between these two tests, the latter being confused with the first. To compare ...
Mendes Nuno D - - 2013
MOTIVATION: Logical (Boolean or multi-valued) modelling is widely employed to study regulatory or signalling networks. Even though these discrete models constitute a coarse, yet useful, abstraction of reality, the analysis of large networks faces a classical combinatorial problem. Here, we propose to take advantage of the intrinsic modularity of inter-cellular ...
C Barros Rodrigo - - 2013
Abstract This study reports the empirical analysis of a hyper-heuristic evolutionary algorithm that is capable of automatically designing top-down decision-tree induction algorithms. Top-down decision-tree algorithms are of great importance, considering their ability of providing an intuitive and accurate knowledge representation for classification problems. The automatic design of these algorithms seems ...
Eshghi Marziye - - 2013
Spectral moment analysis (SMA) was used to describe voiceless alveolar and velar stop-plosive production in Persian-speaking children with repaired cleft lip and palate (CLP). Participants included 11 children with bilateral CLP who were undergoing maxillary expansion and 20 children without any type of orofacial clefts. Four of the children with ...
White Bryan P - - 2013
Purpose: This case report reviews the presentation, evaluation, and treatment of persistent hypoglycemia in a patient without a history of diabetes. The use of laboratory tests to differentiate between drug-induced and disease-induced hypoglycemia is reviewed.Summary: A 51-year-old female with multiple medical conditions including bipolar disorder and no history of diabetes ...
Liao Wei-Hung - - 2013
The electronic structures of the Bbt(Br)E═M(PCy(3))(2) (E = C, Si, Ge, Sn, Pb and M = Pt, Pd) complexes and their potential energy surfaces for the formation and water addition reactions were studied using density functional theory (B3LYP/LANL2DZ). The theoretical evidence suggests that the bonding character of the E═M double ...
de las Heras Javier J Division of Pediatric Metabolism, Hospital Universitario de Cruces, Barakaldo, Vizcaya, - - 2013
To 1) determine if plasma 25-hydroxyvitamin D (25[OH]D) concentrations differ among obese youth with normal glucose tolerance (NGT) versus prediabetes versus type 2 diabetes and 2) assess the relationships between 25(OH)D and in vivo insulin sensitivity and β-cell function in this cohort. Plasma 25(OH)D concentrations were examined in banked specimens ...
Shih Chih-Jen - - 2013
A central question in graphene chemistry is to what extent chemical modification can control an electronically accessible band gap in monolayer and bilayer graphene (MLG and BLG). Density functional theory predicts gaps in covalently functionalized graphene as high as 2 eV, while this approach neglects the fact that lattice symmetry ...
Boscolo Sabrina - - 2013
Palytoxins are potent marine biotoxins that have recently become endemic to the Mediterranean Sea, and are becoming more frequently associated with seafood. Due to their high toxicity, suitable methods to quantify palytoxins are needed. Thus, we developed an indirect sandwich ELISA for palytoxin and 42-hydroxy-palytoxin. An intra-laboratory study demonstrated sensitivity ...
Harwood Benjamin N BN Molecular Pharmacology Research Center, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, - - 2013
The study of complex heterodimeric peptide ligands has been hampered by a paucity of pharmacological tools. To facilitate such investigations, we have explored the utility of membrane tethered ligands (MTLs). Feasibility of this recombinant approach was explored with a focus on Drosophila bursicon, a heterodimeric cystine-knot protein that activates the ...
Karjalainen Oskari K - - 2013
To All(oc) involved: A palladium-catalyzed formal 5-endo-trig heteroannulation of enones generated in situ from amino-acid-derived β-keto nitriles has been realized (see scheme; Alloc=allyl carbamate). The reaction proceeds with allyl-group transfer from the carbamate protecting group to generate two new contiguous stereocenters, including one quaternary center, with high selectivity.
Zalibera Michal - - 2013
The properties of p-phenylene-diamine (PD)-based systems substantially depend on the molecular topology. The singly bridged PD analogues HMPD and OMPD in which the PD rings are connected by a flexible linker reveal particular electronic properties in their radical cations and dications. The EPR and UV-Vis spectra of the HMPD(2+●●) were ...
Lin Xufeng - - 2013
The dehydration mechanisms for glucose in β-pyranose (BP) and in open-chain (OC) forms, catalyzed by acids homogeneously and heterogeneously, were investigated using density functional and two-layer ONIOM calculations. The first dehydration reaction and competing reaction pathways are the main focus of the present study. The energetics of five dehydration and ...
Fini Milena - - 2013
Hyaline cartilage lesions represent an important global health problem. Several approaches have been developed in the last decades to resolve this disability cause, including tissue engineering, but to date there is not a definitive procedure able to promote a repair tissue with the same mechanical and functional characteristics of native ...
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