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Kelsey John E JE Department of Psychology and Program in Neuroscience, Bates College, Canham House, Room 103, 146 Wood St, Lewiston, ME 04240, USA. - - 2013
Cigarette smokers typically display impulsivity by preferring immediate rewards over larger, delayed rewards at shorter delays than do non-smokers. Suggesting causality, nicotine injections in rats increase the choice for an immediate reward over a larger, delayed reward. To examine the generality of this latter effect, the present study employed a ...
Li Li-Hua - - 2013
Increasing evidence suggests that 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) levels are associated with metabolic syndrome (MetS). In 2010, we explored the association of serum 25(OH)D and PTH levels with MetS in 1,390 Chinese participants, aged 20-83 years. Anthropometric phenotypes, blood pressure, and the incidence of MetS were evaluated. In ...
Mainini Veronica - - 2013
MALDI imaging mass spectrometry (IMS) is a unique technology to explore the spatial distribution of biomolecules directly on tissues. It allows the in situ investigation of a large number of small proteins and peptides. Detection of high molecular weight proteins through MALDI IMS still represents an important challenge, as it ...
Bartels Lars E - - 2013
BACKGROUND: In Crohn's disease (CrD), vitamin D may help to balance an exaggerated immune response and thereby improve the disease course. The immunomodulating effects depend on the activation of 25-hydroxy vitamin D3 (25-D3), into 1,25-dihydroxy vitamin D3 (1,25-D3). This activation has previously been shown to take place in dendritic cells ...
Drabova Lucie - - 2013
In this study, levels of several groups of environmental contaminants represented by PAHs, PCBs, organochlorine pesticides and polybrominated diphenyl ethers were determined in various types of canned smoked and non-smoked fish and seafood products (54 samples) obtained from the Czech market. PAHs were detected in all of the studied samples, ...
Matallana-Ramirez Lilian P - - 2013
Senescence is a highly regulated process that involves the action of a large number of transcription factors. The NAC transcription factor ORE1 (ANAC092) has recently been shown to play a critical role in positively controlling senescence in Arabidopsis thaliana, however, no direct target gene through which it exerts its molecular ...
Kreth Simone - - 2013
Favorable outcome after chemotherapy of glioblastomas cannot unequivocally be linked to promoter hypermethylation of the O (6)-methylguanine-DNA methyltransferase (MGMT) gene encoding a DNA repair enzyme associated with resistance to alkylating agents. This indicates that molecular mechanisms determining MGMT expression have not yet been fully elucidated. We here show that glioblastomas ...
Enger Shirin A - - 2013
The purpose of this work was to present the fundamental dosimetric characteristics of a hypothetical (153)Gd brachytherapy source using the AAPM TG-43U1 dose-calculation formalism. Gadolinium-153 is an intermediate-energy isotope that emits 40-100 keV photons with a half-life of 242 days. The rationale for considering (153)Gd as a brachytherapy source is for its ...
Eijkelenboom Astrid - - 2013
Forkhead box O (FOXO) transcription factors are key players in diverse cellular processes affecting tumorigenesis, stem cell maintenance and lifespan. To gain insight into the mechanisms of FOXO-regulated target gene expression, we studied genome-wide effects of FOXO3 activation. Profiling RNA polymerase II changes shows that FOXO3 regulates gene expression through ...
Hanada Kousuke - - 2013
It is likely that many small ORFs (sORFs; 30-100 amino acids) are missed when genomes are annotated. To overcome this limitation, we identified ∼8,000 sORFs with high coding potential in intergenic regions of the Arabidopsis thaliana genome. However, the question remains as to whether these coding sORFs play functional roles. ...
Pina Adriana - - 2013
The protective adaptive immune response in paracoccidioidomycosis, a mycosis endemic among humans, is mediated by T cell immunity, whereas impaired T cell responses are associated with severe, progressive disease. The early host response to Paracoccidioides brasiliensis infection is not known since the disease is diagnosed at later phases of infection. ...
Fu Li-Ping - - 2013
A microwave-assisted regioselective reaction dealing with arylglyoxal monohydrate, diverse N-aryl enaminones, and indoles to achieve 3,2'- and 3,3'-bis-indoles by varying substituted indole substrate is reported. The 2-unsubstituted indoles resulted in the 3,2'-bis-indole skeleton, whereas indoles bearing methyl or phenyl group at C2 led to the 3,3'-bis-indoles with simultaneous formation of ...
Rand David G - - 2013
Classical economic models assume that people are fully rational and selfish, while experiments often point to different conclusions. A canonical example is the Ultimatum Game: one player proposes a division of a sum of money between herself and a second player, who either accepts or rejects. Based on rational self-interest, ...
Saari Jonathan I - - 2013
Optical pumping of semiconductor nanocrystals with femtosecond pulse sequences was performed in order to modulate multiexciton populations. We show for the first time that control of multiexciton populations produces high speed modulation of stimulated emission. Based upon the speed of multiexcitonic processes in nanocrystals, we show modulation rates approaching 1 ...
Obad-Kovačević Dragica - - 2013
The objective of this study was to compare qualitative cytomorphology and morphometric characteristics of parotid gland tumor cells, with the aid of a computer-assisted system of image analysis. Routine qualitative cytologic and quantitative morphometric results from 64 parotid gland tumors were compared. Ultrasound (US)-guided fine-needle aspiration (FNA) specimens were taken ...
Peter Beate B Department of Speech and Hearing Sciences, University of Washington, Seattle, WA 98195, USA. - - 2013
The purpose of this study was to evaluate a global deficit in sequential processing as candidate endophenotypein a family with familial childhood apraxia of speech (CAS). Of 10 adults and 13 children in a three-generational family with speech sound disorder (SSD) consistent with CAS, 3 adults and 6 children had ...
Li Fei - - 2013
We have fabricated supra-amphiphiles by charge-transfer complexation of azulene-based amphiphiles and pyrene in water, and the self-assembled nanostructures can reversibly change between cylindrical micelles and disklike nanosheets in response to interaction with guest molecules.
Watts Anne O AO Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, 1081 HV Amsterdam, The - - 2013
Chemokine receptors form a large subfamily of G protein-coupled receptors that predominantly activate heterotrimeric Gi proteins and are involved in immune cell migration. CCX-CKR is an atypical chemokine receptor with high affinity for CCL19, CCL21, and CCL25 chemokines, but is not known to activate intracellular signaling pathways. However, CCX-CKR acts ...
Zamanpoor Mansour - - 2013
Abstract Objective: to quantify circulating fetal DNA (fDNA) levels in the second and third trimesters of normal healthy pregnant individuals and pregnant women with the following clinical conditions: gestational diabetes mellitus (GDM), iron deficiency anemia and gestational hypertension (GHT). Methods: The SRY gene which is located on Y chromosome was ...
Alaghehbandan Reza - - 2013
The clinical usefulness of the ProEx C (Becton Dickinson) and PreTect HPV-Proofer E6/E7 mRNA tests (Proofer; Norchip) for the triage of ASCUS and LSIL cytology was determined in comparison with the Hybrid Capture 2 HPV DNA test (HC2; Qiagen). The study population consisted of women with a history of abnormal ...
Ambinder Alexander J - - 2013
BACKGROUND: Mantle cell lymphoma (MCL) is a rare B cell lymphoma that varies in clinical behavior with some patients experiencing aggressive disease with short survival, whereas others have indolent behavior. We examined the association between primary disease site and survival in MCL patients to identify subgroups with distinct characteristics. METHODS: ...
Onuma Yoshinobu - - 2013
Aims: To assess the safety and performance of the XIENCE V everolimus-eluting stent (EES) versus the TAXUS paclitaxel-eluting stent (PES) in the treatment of patients with de novo coronary artery lesions after a five-year follow-up period. Second-generation drug-eluting stents (DES) were developed with the aim of improving the safety profile ...
Zhang Xianmin - - 2013
The integration of organic semiconductors and magnetism has been a fascinating topic for fundamental scientific research and future applications in electronics, because organic semiconductors are expected to possess a large spin-dependent transport length based on weak spin-orbit coupling and weak hyperfine interaction. However, to date, this length has typically been ...
Ng Christopher W CW Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, - - 2013
The earliest stages of Huntington disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin (HTT) protein. To explore the hypothesis that DNA methylation may be altered in cells expressing mutated HTT, we use reduced representation ...
Davies Andrew - - 2013
Abstract Objective: To evaluate the long-term cost-effectiveness of 12-months treatment with prasugrel versus clopidogrel from four European healthcare systems' perspectives (Germany, Sweden, the Netherlands, and Turkey). Methods: In the TRITON-TIMI 38 trial, patients with an acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) were treated with prasugrel or clopidogrel. ...
Wang Tiange T Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, - - 2013
Prolactin is a major stimulus for the β-cell adaptation during gestation and guards postpartum women against gestational diabetes. Most studies of the role of prolactin on glucose metabolism have been conducted in humans and animals during pregnancy. However, little is known concerning the association between circulating prolactin and glucose metabolism ...
Schneider Bryan P BP Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA. - - 2013
Clinically validated biomarkers for anti-angiogenesis agents are not available. We have previously reported associations between candidate VEGFA single-nucleotide polymorphisms (SNP) and overall survival (OS) in E2100. The associations between tumor VEGFA amplification and outcome are evaluated here. E2100 was a phase III trial comparing paclitaxel with or without bevacizumab for ...
Singh Ajay K - - 2013
PURPOSE OF REVIEW: The association of the metabolic syndrome (MetS) with cardiovascular risk, mortality, type 2 diabetes mellitus, stroke, nonfatty liver disease and gout is well known. However, the association of the MetS with chronic kidney disease (CKD) is now emerging. This review discusses the epidemiology, pathology and potential mechanisms ...
Herman Joseph M - - 2013
TNFerade biologic is a novel means of delivering tumor necrosis factor alpha to tumor cells by gene transfer. We herein report final results of the largest randomized phase III trial performed to date among patients with locally advanced pancreatic cancer (LAPC) and the first to test gene transfer against this ...
Anderson-Schmidt Heike H Section of Psychiatric Genetics, Department of Psychiatry and Psychotherapy, University Medical Centre Göttingen, Goettingen, - - 2013
The XXth World Congress of Psychiatric Genetics (WCPG), sponsored by The International Society of Psychiatric Genetics (ISPG) took place in Hamburg, Germany on October 14-18, 2012. Approximately 600 participants gathered to discuss the latest findings in this rapidly advancing field. The following report was written by student travel awardees. Each ...
Wu Xinyue - - 2013
A silver bullet: The title reaction results in selective formation of trifluoromethylated alkanes, and is in contrast to the previously reported transition-metal-catalyzed trifluoromethylation of olefins to generate a series of trifluoromethylated allylic compounds. Preliminary mechanistic investigations indicate that the current hydrotrifluoromethylation proceeds through a pathway involving a CF(3) radical species.
Yang Bing - - 2013
Notch signaling has been shown to be important in osteoblast differentiation. Therapeutic radiation has been shown to alter the skeletal system, yet little information is available on the changes in Notch signaling in irradiated osteoblasts. The purpose of this study was to analyze the effect of radiation therapy with 2 ...
Young Duncan D John Radcliffe Hospital and the University of Oxford, Oxford, United Kingdom. - - 2013
Patients with the acute respiratory distress syndrome (ARDS) require mechanical ventilation to maintain arterial oxygenation, but this treatment may produce secondary lung injury. High-frequency oscillatory ventilation (HFOV) may reduce this secondary damage. In a multicenter study, we randomly assigned adults requiring mechanical ventilation for ARDS to undergo either HFOV with ...
Berashevich J - - 2013
The electronic properties of polycrystalline lead oxide consisting of a network of single-crystalline α-PbO platelets and the formation of native point defects in the α-PbO crystal lattice are studied using first-principles calculations. The results suggest that the polycrystalline nature of α-PbO causes the formation of lattice defects (i.e., oxygen and ...
Chen Hong - - 2013
In this letter, we consider a density-level detection (DLD) problem by a coefficient-based classification framework with ℓ(1)-regularizer and data-dependent hypothesis spaces. Although the data-dependent characteristic of the algorithm provides flexibility and adaptivity for DLD, it leads to difficulty in generalization error analysis. To overcome this difficulty, an error decomposition is ...
Yang Qing - - 2013
ZnO nanowire inorganic/organic hybrid ultraviolet (UV) light-emitting diode (LED) have attracted considerable attention as they not only combine the high flexibility of polymers with the structural and chemical stability of inorganic nanostructures, but also have the higher light extraction efficiency than thin film structures. However, up to date, the external ...
Kim Gwang Suk GS Nursing Policy Research Institute, College of Nursing, Yonsei University, Seoul, Republic of - - 2013
The purpose of this study was to identify the correlates of depressive symptoms among women who have immigrated to Korea for marriage. Cross-sectional data reflecting Korean language fluency, acculturation, acculturative stress, general stress, and marital satisfaction were collected from 223 married immigrant women. There was a significant negative correlation between ...
Asdonk T T Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn. - - 2013
A 49-year-old patient was admitted to our ward because of a troponin elevation (non ST-elevation myocardial infarction) following a rhinoscopy in an external hospital. The patient complained of typical angina, chronic rhinitis and epistaxis. Analysis of the nasal biopsy had shown the histological finding of granulomatosis with polyangiitis (Wegener's granulomatosis). ...
Hamon Martial - - 2013
Aims: To report the four-month and nine-month angiographic results as well as one-year clinical follow-up from the first-in-man study with the silicon carbide and sirolimus-eluting bioabsorbable polymer (poly-L-lactic acid (PLLA) polymer) -coated cobalt-chromium Orsiro stent. Methods and results: A group of 30 patients with documented myocardial ischaemia related to a ...
Kalies Stefan - - 2013
The use of laser induced surface plasmons on metal nanoparticles has proven to be an excellent tool for the delivery of molecules like siRNA and DNA into cells. However, a detailed understanding of the basic mechanisms of molecular uptake and the influence of parameters like biological environment is missing. In ...
Wang Bin - - 2013
Monsoon rainfall and tropical storms (TSs) impose great impacts on society, yet their seasonal predictions are far from successful. The western Pacific Subtropical High (WPSH) is a prime circulation system affecting East Asian summer monsoon (EASM) and western North Pacific TS activities, but the sources of its variability and predictability ...
Zhan Wen-Wen - - 2013
Metal-organic frameworks (MOFs) and related material classes are attracting considerable attention for their applications in gas storage/separation as well as catalysis. In contrast, research concerning potential uses in electronic devices (such as sensors) is in its infancy, which might be due to a great challenge in the fabrication of MOFs ...
Dombi Peter - - 2013
We demonstrate the generation of ultrafast electrons from tailored metallic nanoparticles, and unravel the role of plasmonic field enhancement in the generation of electrons by comparing resonant and off-resonant particles, as well as different particle geometries. We find that electrons become accelerated virtually within a half-cycle of the driving light ...
Konno Satoshi - - 2013
OBJECTIVE:: Although hypertension is a well known risk factor for microalbuminuria, it is unclear whether blood pressure less than 140/90 mmHg could be a risk for microalbuminuria. We assessed the relationship between baseline blood pressure and the future onset of microalbuminuria in the general population. METHODS:: We studied 2603 town inhabitants ...
Barker Tyson V - - 2013
Behavioral inhibition (BI) is a temperament characterized during early childhood by increased fearfulness to novelty, social reticence to unfamiliar peers, and heightened risk for the development of anxiety. Heightened startle responses to safety cues have been found among behaviorally inhibited adolescents who have an anxiety disorder suggesting that this measure ...
Myles-Worsley Marina - - 2013
Growing evidence for genetic overlap between schizophrenia (SCZ) and bipolar disorder (BPD) suggests that causal variants of large effect on disease risk may cross traditional diagnostic boundaries. Extended multigenerational families with both SCZ and BPD cases can be a valuable resource for discovery of shared biological pathways because they can ...
Bizzaro Nicola - - 2013
ABSTRACT: INTRODUCTION: The diagnostic, predictive and prognostic role of anti-cyclic citrullinated peptide (CCP) antibodies in rheumatoid arthritis (RA) patients is widely accepted. Moreover, detection of these antibodies in subjects presenting with undifferentiated arthritis (UA) is associated with a significant risk to develop the disease. On the other hand, clinical and ...
Toivonen Sanna S Research Programs Unit, Molecular Neurology, Biomedicum Stem Cell Center, University of Helsinki, Helsinki, - - 2013
Functional hepatocytes, cardiomyocytes, neurons, and retinal pigment epithelial (RPE) cells derived from human embryonic stem cells (hESCs) or human induced pluripotent stem cells (hiPSCs) could provide a defined and renewable source of human cells relevant for cell replacement therapies, drug discovery, toxicology testing, and disease modeling. In this study, we ...
Steury Elinda Enright - - 2013
Transcultural nursing educators can be change agents for health issues in other cultures. Yet unfamiliar disease processes and the foreign environment provide challenges that must be overcome to achieve a lasting, effective, and positive change. Rogers's Diffusion of Innovations Model can be used to plan and implement community-focused interventions into ...
Harb Carmen - - 2013
Nine [Ru(Tp)(dppe)L] complexes, where Tp is hydrotris(pyrazol-1-yl)borate, dppe is ethylenebis(diphenylphosphine), and L is (4-nitrophenyl)cyanamide (NO(2)pcyd(-)), (2-chlorophenyl)cyanamide (2-Clpcyd(-)), (3-chlorophenyl)cyanamide (3-Clpcyd(-)), (2,4-dichlorophenyl)cyanamide (2,4-Cl(2)pcyd(-)), (2,3-dichlorophenyl)cyanamide (2,3-Cl(2)pcyd(-)), (2,5-dichlorophenyl)cyanamide (2,5-Cl(2)pcyd(-)), (2,4,5-trichlorophenyl)cyanamide (2,4,5-Cl(3)pcyd(-)), (2,3,5,6-tetrachlorophenyl)cyanamide (2,3,5,6-Cl(4)pcyd(-)), and (pentachlorophenyl)cyanamide (Cl(5)pcyd(-)), and the dinuclear complex [{Ru(Tp)(dppe)}(2)(μ-adpc)], where adpc(2-) is azo-4,4-diphenylcyanamide, have been prepared and characterized. The crystal structures of ...
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