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Hansen C H - - 2013
BACKGROUND: Medical patients are often screened for distress in the clinic using a questionnaire such as the Hospital Anxiety and Depression Scale (HADS) while awaiting their consultation. However, might the context of the clinic artificially inflate the distress score? To address this question we aimed to determine whether those who ...
Díaz Julián A - - 2013
Unlike the sharp melting behavior of DNA-linked nanoparticle aggregates, the melting of DNA strands from individual gold nanoparticles is broad despite the high surface density of bound DNA. Here, it is demonstrated how sharpened melting can be achieved in colloidal nanoparticle systems using branched DNA-doubler structures hybridized with complementary DNA-doublers ...
Bombard Yvonne Y Yale University, School of Public Health & Memorial Sloan-Kettering Cancer Center, Center for Health Policy and Outcomes and Clinical Genetics Service, New York, NY, - - 2013
Our objective was to explore citizens' informed and reasoned values and expectations of personalized medicine, a timely yet novel genomics policy issue. A qualitative, public deliberation study was undertaken using a citizens' reference panel on health technologies, established to provide input to the health technology assessment process in Ontario, Canada. ...
Abdolahad M - - 2013
Vertically aligned carbon nanotube (VACNT) arrays have been demonstrated as probes for rapid quantifying of cancer cell deformability with high resolution. Through entrapment of various cancer cells on CNT arrays, the deflections of the nanotubes during cell deformation were used to derive the lateral cell shear force using a large ...
Kukwa Wojciech - - 2013
BACKGROUND: A high level of endogenous erythropoietin (EPO) may be associated with a smaller infarct size determined by the release of necrosis markers. Sleep-disordered breathing (SDB) is a well-known risk factor for cardiovascular diseases. In contrast, protective effects of SDB have also been described. The potential role of increased levels ...
Aya-Bonilla Carlos - - 2013
We employed a Hidden-Markov-Model (HMM) algorithm in loss of heterozygosity (LOH) analysis of high-density single nucleotide polymorphism (SNP) array data from Non-Hodgkin's lymphoma (NHL) entities, follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL). This revealed a high frequency of LOH over the chromosomal region 11p11.2, containing the gene encoding ...
Schaerli Yolanda - - 2013
The promise of wide-ranging biotechnology applications inspires synthetic biologists to design novel genetic circuits. However, building such circuits rationally is still not straightforward and often involves painstaking trial-and-error. Mimicking the process of natural selection can help us to bridge the gap between our incomplete understanding of nature's design rules and ...
Babashah Sadegh - - 2013
Aberrant expression and function of microRNAs (miRNAs) in leukemia have added a new layer of complexity to the understanding of development and progression of the disease state. However, their targeting of specific signaling pathways responsible for the maintenance and survival properties of leukemic stem cell (LSC) still remains to be ...
Verspreet Joran - - 2013
The degradation of endogenous wheat grain fructans, oligosaccharides with possible health promoting potential, during wheat whole meal bread making was investigated and several strategies to prevent their degradation were evaluated. Up to 78.4 ± 5.2% of the fructans initially present in wheat whole meal were degraded during bread making by ...
Willig James H - - 2013
In primary care settings, follow-up regarding the outcome of acute outpatient visits is largely absent. We sought to develop an automated interactive voice response system (IVRS) for patient follow-up with feedback to providers capable of interfacing with multiple pre-existing electronic medical records (EMRs). A system was designed to extract data ...
Moat Stuart J SJ Wales Newborn Screening Laboratory, Department of Medical Biochemistry and Immunology, University Hospital Wales, Cardiff, Wales, - - 2013
Duchenne muscular dystrophy (DMD), a progressive X-linked neuromuscular disorder, has an estimated worldwide incidence of 1:3500 male births. Currently, there are no curative treatments and the mean age of diagnosis is 5 years. In addition, subsequent pregnancies frequently occur before a diagnosis is made in an index case. An 'opt ...
Kim Dong Hoe - - 2013
Herein, we report on the synthesis of phase-pure rutile walnut-like TiO(2) (W-TiO(2)) spheres composed of single-crystalline nanorod-building blocks using a surfactant-free non-aqueous acidic modified "benzyl alcohol route". Based on the various HCl concentration- and reaction time-dependent experiments, an effect of hydrochloric acid on the phase formation mechanism in a non-aqueous ...
Tellier Stéphanie S Pediatric Nephrology, Hôpital des Enfants, Toulouse, France. - - 2013
Rituximab (RTX) has recently showed promising results in the treatment of steroid-dependent idiopathic nephrotic syndrome (SDNS). This was a retrospective multicenter study of 18 children treated with RTX for SDNS, with a mean follow-up of 3.2 years. RTX was introduced because of side effects or relapses during therapy with immunosuppressive ...
Hernández Sarmiento José Mauricio - - 2013
Homeless people are highly susceptible to tuberculosis. It has been suggested that this population have high rates of mental disorders associated with tuberculosis. We assessed tuberculosis incidence, its transmission patterns and association with socio-demographic factors and mental disorders in Colombian homeless people. Prospective study which socio-demographic characteristics and mental disorders ...
Nikbakht Gholamreza - - 2013
Microsatellite LEI0258 is a genetic marker for chicken MHC haplotypes and can be used as an indicator of the influence of population genetics on immune responses. LEI0258 microsatellite variability in three Iranian indigenous chicken populations (Khorasan, Marandi, and Arian) was investigated. In total, 142 Khorasan, 42 Marandi, and 58 Arian ...
Ma Xiaorong X Department of Plastic and Reconstructive Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of - - 2013
We aimed to assess the efficacy and safety of low-dose propranolol for treatment of infantile hemangiomas (IHs) in China. Our prospective study included data from 89 patients with IH, aged 1-12 months. Plasma renin activity, angiotensin II, and aldosterone were measured before initiation of propranolol therapy. Patients were administered propranolol ...
Okon J B - - 2013
Aim. To determine the prevalence of endoscopic lesions, according to age and location, in patients with rectal bleeding who underwent total colonoscopy. Methods. Retrospective observational study examining records from the hepatogastroenterology department at the Cocody University Hospital (Abidjan) of colonoscopies for rectal examination from September 1, 1991, through August 15, ...
Astray R M RM Laboratório de Imunologia Viral, Instituto Butantan, Av. Vital Brasil 1500, São Paulo, 05503-900, Brazil, - - 2013
Recombinant rabies virus glycoprotein (RVGP) was expressed in cell membranes of stably transfected Drosophila S2 cells using constitutive and inducible promoters. Although with quantitative differences of RVGP expression in both systems, the cDNA transcription, as evaluated by relative RVGP mRNA levels measured by qRT-PCR, sustained the amount of RVGP producing ...
Mitin Timur - - 2013
During the past 25 years, prospective clinical trials have established that bladder preservation therapy for select patients with muscle-invasive bladder cancer is a safe and effective alternative to an immediate cystectomy. Cisplatin-based chemoradiation is the most well-studied and accepted component of trimodality therapy; however, other systemic agents have recently been shown ...
Farhadi M - - 2013
Background: A subjective feeling of nasal airflow obstruction is a common symptom. An objective method for quantitative measurement of nasal airflow has long been desired. Rhinomanometry and acoustic rhinometry have been developed for anatomical and physiological evaluation of nasal obstruction. This study was designed to determine the usefulness of a ...
Riaz Sara - - 2013
We report the spontaneous fragmentation of gold nanoparticles (AuNPs) induced, in aqueous solution at room temperature, by thiol derivative of ubiquinone, which involves the energetic electron injection from thiol-ubiquinone to the gold nanoparticles.
Rey de Castro Jorge - - 2013
PURPOSE: The purpose of this study is to describe the clinical and polysomnographic differences found in patients diagnosed with obstructive sleep apnea-hypopnea (OSAH), with or without excessive daytime sleepiness (EDS) measured by the Epworth Sleepiness Scale (ESS). METHODS: A physical examination, ESS, and polysomnography were applied to all the participants, ...
Jiang Liangdong - - 2013
Osteosarcoma and Ewing's sarcoma are the two most common primary malignant bone tumors, and findings of prognostic factors are important for clinicians to decide treatment options. High p53 expression has been implicated in tumor development and progression, but studies investigating the prognostic role of p53 overexpression in malignant bone tumors ...
Volpe G G Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, - - 2013
The interaction between the receptor FLT3 (FMS-like tyrosine kinase-3) and its ligand FL leads to crucial signalling during the early stages of the commitment of haematopoietic stem cells. Mutation or over-expression of the FLT3 gene, leading to constitutive signalling, enhances the survival and expansion of a variety of leukaemias and ...
Aytan Hakan - - 2013
PURPOSE: The role of thyroid function in biochemical markers of first trimester screening has not been assessed. The aim of the present study was to investigate if there were any relation between maternal thyroid hormones and free-beta subunit of human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma protein A (PAPP-A) levels ...
Kottiappan Madasamy - - 2013
Tea is the most commonly consumed beverage in the world. Tea infusion is prepared by pouring boiling hot water over cured leaves of the Camellia sinensis plant. Such a beverage should be free from toxic chemicals. Studies on the monitoring of pesticide residues in tea of South India had been ...
Inui Yuji - - 2013
Formation of a π-π stacked assembly between a Na(+)-templated G-quartet and octaethylporphyrinatonickel(ii) was observed by spectroscopic methods in methanol/chloroform and the formation dynamics of the assembly was elucidated.
Maydt Daniela - - 2013
Abstract 1. Chalcones are structural analogues of benzalacetophenone (BAP). Several derivatives have been identified in plants and anticarcinogenic and anti-inflammatory properties were attributed to the compounds, probably related to their direct antioxidant activity or stimulatory effects on the expression of endogenous defence enzymes like hemeoxygenase-1 (HO-1). HO-1 expression is triggered ...
Leslie W D WD Department of Medicine (C5121), University of Manitoba, 409 Tache Avenue, Winnipeg, Manitoba, Canada. - - 2013
High direct incremental healthcare costs post-fracture are seen in the first year, but total costs from a third-party healthcare payer perspective eventually fall below pre-fracture levels. We attribute this to higher mortality among fracture cases who are already the heaviest users of healthcare ("healthy survivor bias"). Economic analyses that do ...
Conconi A - - 2013
ABSTRACT Central nervous system (CNS) relapse has not been extensively studied in mantle cell lymphoma (MCL). We retrospectively analysed the risk factors and pattern of CNS relapse in consecutive MCL patients. We identified 142 cases of MCL treated from 1980 to 2011. Median age at diagnosis was 68 years; 82% ...
Akinbami Catherine A O CA Faculty of Social Science Building, Centre for Industrial Research and Development, Obafemi Awolowo University, Ile-Ife, Nigeria. - - 2013
In rural Nigeria, food processing is mostly engaged in by women and children. Most of these processes are done using outdated technologies that make use of traditional woodstoves. This article presents the health and environmental implications of the rural female entrepreneurs involved in food processing and proffer means of bettering ...
Costas Benjamín - - 2013
Amino acids (AA) regulate key metabolic pathways, including some immune responses. Therefore, this study aimed to assess whether an increased availability of dietary AA can mitigate the expected increase in plasma cortisol and metabolites levels due to high stocking density and its subsequent immunosuppression. Senegalese sole (Solea senegalensis) were maintained ...
Anderson D P - - 2013
SUMMARY Surveying and declaring disease freedom in wildlife is difficult because information on population size and spatial distribution is often inadequate. We describe and demonstrate a novel spatial model of wildlife disease-surveillance data for predicting the probability of freedom of bovine tuberculosis (caused by Mycobacterium bovis) in New Zealand, in ...
Lenoir-Wijnkoop I - - 2013
Non-communicable diseases (NCD) are a major and increasing contributor to morbidity and mortality in developed and developing countries. Much of the chronic disease burden is preventable through modification of lifestyle behaviours, and increased attention is being focused on identifying and implementing effective preventative health strategies. Nutrition has been identified as ...
Conroy Thierry - - 2013
In 2010, the FOLFIRINOX regimen (bolus and infusional 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) emerged as a new option in patients with metastatic pancreatic cancer and a good performance status. However, at that time, some doubts were raised regarding safety issues. Similarly, no data on FOLFIRINOX were published in patients with ...
Withers Kathleen - - 2013
As part of its Medical Technologies Evaluation Programme, the National Institute of Health and Clinical Excellence (NICE) invited the manufacturer, Covidien, to provide clinical and economic evidence for the evaluation of the Pipeline™ embolization device (PED) for the treatment of complex intracranial aneurysms. Cedar; a consortium between Cardiff and Vale ...
Deb Roumi - - 2013
OBJECTIVE: To assess the role of sociodemographic and nutritional factors in the incidence of births affected by neural tube defects (NTD) in the North Indian population. DESIGN: Case-control study. SETTING: Government hospitals of Delhi, India. SUBJECTS: Subjects comprised 284 mothers of NTD children (cases) and 568 mothers of healthy children ...
Dos Santos Viviane Gularte Tavares - - 2013
Sixty specimens of the "cururu" toad, Rhinella icterica (Spix 1824) (Bufonidae), were collected in Campo Belo do Sul, State of Santa Catarina, Brazil, between May 2009 and January 2011, and were examined for the presence of helminth parasites. Nine species of adult helminths were found: Catadiscus cohni, Rudolphitrema rudolphii, Cylindrotaenia ...
Ohno Tsutomu - - 2013
Soil organic matter (SOM) is involved in many important ecosystem processes. Ultrahigh resolution mass spectrometry has become a powerful technique in the chemical characterization of SOM, allowing assignment of elemental formulae for thousands of peaks resolved in a typical mass spectrum. We investigated how the addition of N, S, and ...
Halpern Carolyn Tucker - - 2013
The objective of this study is to examine the association between physical and sexual violence exposure and somatic symptoms among female adolescents. We studied a nationally representative sample of 8,531 females, aged 11-21 years, who participated in the 1994-1995 Wave I of the National Longitudinal Study of Adolescent Health (Add Health). ...
Allen Hillary F HF Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, - - 2013
The nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin organization, gene transcription, genomic stability and developmental signaling. NuRD has a unique dual enzymatic activity, containing an ATPase and a histone deacetylase among its six core subunits. Recent studies indicate that NuRD composition and the interplay between subunits may dictate the ...
Faião-Flores Fernanda - - 2013
Melanoma is one of the most aggressive types of skin cancer and its incidence rate is still increasing. All existing treatments are minimally effective. Consequently, new therapeutic agents for melanoma treatment should be developed. The DM-1 compound is a curcumin analog that possesses several curcumin characteristics, such as antiproliferative, antitumor, ...
Nimaichand Salam - - 2013
A novel actinobacterium MBRL 251(T), isolated from a sample collected from a limestone quarry at Hundung, Manipur, India, was characterized using a polyphasic approach. The 16S ribosomal RNA gene sequence of strain MBRL 251(T) showed closest similarities with Streptomyces xanthochromogenes NRRL B-5410(T) (99.6%) and Streptomyces michiganensis NBRC 12797(T) (99.6%). The ...
Ho Ching-Yin - - 2013
Familial aggregation of nasopharyngeal carcinoma (NPC) has been widely reported. The excess risk is about 4-8-fold among first-degree relatives of NPC patients compared with those without a family history of the disease. We used nasopharyngoscopy and a narrow-band image system (NBI) to screen NPC high-risk patients and identify a good ...
Tucker Patrick Steven - - 2013
Abstract Context: Kidney-related pathologies have increasing prevalence rates, produce a considerable financial burden, and are characterized by elevated levels of oxidative stress (OS). Objective: This review examines relationships between chronic kidney disease (CKD) and markers of OS and antioxidant status (AS). Methods: A systematic review of MEDLINE-indexed clinical trials, randomized ...
Chandra Siddharth - - 2013
The influenza pandemic of 1918-19 was the single most lethal short-term epidemic of the twentieth century. For Indonesia, the world's fourth most populous country, the most widely used estimate of mortality from that pandemic is 1.5 million. We estimated mortality from the influenza pandemic in Java and Madura, home to ...
McClellan Kelly A - - 2013
While the importance of intrafamilial communication of hereditary cancer risk has been acknowledged, the factors that promote and act as barriers to patients disclosing their information to their families are complex and emerging. This raises the question: How are patients guided in practice to contemplate intrafamilial communication? Focusing on breast ...
Ramachandran Puthucode Venkatakrishnan - - 2013
RNA interference (RNAi) is an evolutionary conserved gene regulation pathway that has emerged as an important discovery in the field of molecular biology. One of the important advantages of RNAi in therapy is that it brings about efficient downregulation of gene expression by targeting complementary transcripts in comparison with other ...
Li Chunxiang - - 2013
Two neutral cyclometalated platinum(ii) complexes, Pt(DPP)(acac) and Pt(BPP)(acac) (DPP = 2,4-diphenylpyridine, BPP = 2-(4-tert-butylphenyl)-4-phenylpyridine, acac = acetylacetone), have been synthesized and characterized by (1)H NMR spectroscopy, mass spectrometry, elemental analyses and by X-ray crystallography for Pt(DPP)(acac). Electrogenerated chemiluminescence (ECL) of the two complexes in the absence or presence of coreactant ...
Borin Sara - - 2013
To extend the knowledge of anaerobic ammonium oxidation (anammox) habitats, bacterial communities were examined in two hypersaline sulphidic basins in Eastern Mediterranean Sea. The 2 m thick seawater-brine haloclines of the deep anoxic hypersaline basins Bannock and L'Atalante were sampled in intervals of 10 cm with increasing salinity. (15)N isotope pairing incubation ...
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