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Results 701 - 750 of 2381
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Liu Rui - - 2013
A series of Pt(ii) bipyridyl complexes with different aryl substituents (Ar = naphthyl (), anthryl (), pyrenyl () and phenothiazyl ()) on the fluorenylacetylide ligands are synthesized and investigated. The influence of the aryl substituent on the photophysics of these complexes is systematically investigated by spectroscopic methods and simulated by ...
Li Yaohang - - 2013
The rapidly increasing number of protein crystal structures available in PDB has naturally made statistical analyses feasible in studying complex high-order inter-residue correlations. In this paper, we report a Context-based Secondary Structure Potential (CSSP) for assessing the quality of predicted protein secondary structures generated by various prediction servers. CSSP is ...
Richter Günther Hs - - 2013
Metastatic spread in Ewing sarcomas (ES) is frequent and haematogenous. G-protein coupled receptor 64 (GPR64), an orphan receptor with normal expression restricted to human epididymis is specifically over-expressed in ES among sarcoma, but also up-regulated in a number of carcinomas derived from prostate, kidney or lung. Inhibition of GPR64 expression ...
Chang Chang-Cheng - - 2013
Introduction Perforator flap transfer has the benefits of minimal donor site morbidity and customization in design. This study reports on the proximal lateral leg perforator (PLLP) flap transfer for head and neck reconstruction.Materials and Methods From January 2000 through December 2009, 18 patients underwent head and neck reconstruction with the PLLP flap, ...
Pu Hanlin - - 2013
The interaction between strictosamide (STM) and human serum albumin (HSA) was investigated by fluorescence spectroscopy, synchronous fluorescence spectroscopy, three-dimensional fluorescence spectroscopy, ultraviolet-visible absorption spectroscopy, circular dichroism spectroscopy and molecular modeling under physiological pH 7.4. STM effectively quenched the intrinsic fluorescence of HSA via static quenching. The binding site number n ...
Sarkozy Clémentine - - 2013
Half of the patients with diffuse large B-cell lymphoma are over 65 years old. These elderly patients frequently have other diseases, some of them severe, which may alter their ability to receive standard curative therapy. However these associated diseases are heterogeneous and only a few contra-indicates chemotherapy treatments. We reviewed ...
Rohweder Dirk - - 2013
Fusarium infections do not only affect the grain, but also the rest of the plant, which result in contamination of plants with the mycotoxin deoxynivalenol (DON). The bioavailability of DON may be influenced by the matrix due to the differences in nutrient composition between grain and straw, particularly the high ...
Luiz Henrique V - - 2013
Objective: To report an extremely rare case of thyroid tuberculosis (TT) with abnormal thyroid function and to review the related literature.Methods: We present the patient's history, clinical findings, laboratory test results, imaging exams, cytological data, management and follow-up. In addition, we perform a review of previously published cases of TT, ...
Martínez-García M Ángeles - - 2013
Context:Sex hormones, particularly androgens, may influence not only adipose tissue distribution but also its functions.Objective:We explored the possibility of sexual dimorphism in adipose tissue and skeletal muscle function.Design:This was a case-control study.Setting:The setting was an academic hospital.Participants:Participants were severely obese men (n = 7), control women (n = 7), and ...
Pruijssers A C - - 2013
BACKGROUND: Anxiety and challenging behaviour (CB) often occur simultaneously in people with intellectual disabilities (ID). Understanding the associations between anxiety and CB may contribute to more accurate diagnoses and management of both anxiety and CB in this population. AIMS: To examine the relationship between anxiety and CB. METHODS: A literature ...
Boster Aaron L - - 2013
OBJECTIVE To describe the clinical, radiological, and histopathological features of a fatal case of progressive multifocal leukoencephalopathy (PML) in a patient with multiple sclerosis treated with natalizumab. We will use this case to review PML risk stratification and diagnosis. DESIGN Case report. SETTING Tertiary referral center hospitalized care. PATIENT A ...
Staudt Svenja - - 2013
It doesn't take much to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP(+) (and a little 2-propanol to reduce it), as well as two catalytic enzymes-a hydroxylating P450 monooxygenase and an alcohol dehydrogenase.
Seyfried Florian - - 2013
Patients with a body mass index (BMI) above 35 kg/m2 with metabolic diseases benefit from Roux-en-Y gastric bypass (RYGB) independently of their final BMI and the amount of body weight lost. However, the weight loss independent metabolic effects induced by RYGB remain less well understood. To elucidate metabolic changes after ...
Brixen Kim - - 2013
Context:Odanacatib, a cathepsin K inhibitor, increases spine and hip areal bone mineral density (BMD) in postmenopausal women with low BMD and cortical thickness in ovariectomized monkeys.Objective:The objective of the study was to examine the impact of odanacatib on the trabecular and cortical bone compartments and estimated strength at the hip ...
Lewiecki E Michael - - 2013
Objectives:Current clinical practice guidelines identify patients at high risk for fracture who are likely to benefit from pharmacological therapy and suggest ways to monitor for effectiveness of therapy. However, there is no clear guidance on when fracture risk has been reduced to an acceptably low level. As a consequence, some ...
Zhu Jing - - 2013
The high-resolution real space mapping of Li-ion diffusion in LiNi(1/3)Co(1/3)Mn(1/3)O(2) cathode within an all-solid-state thin film Li-ion battery has been conducted using advanced Scanning Probe Microscopy Techniques, namely, Band Excitation Electrochemical Strain Microscopy (BE-ESM) and Conductive Atomic Force Microscopy (c-AFM). In addition, local variations of the electrochemical response in LiNi(1/3)Co(1/3)Mn(1/3)O(2) ...
Sun Jian-Ke - - 2013
A bipyridinium ligand with a charge separated skeleton has been introduced into a metal-organic framework to yield a porous material with charge-polarized pore space, which exhibits selective adsorption for polar guest molecules and can be further used in gas chromatography for the separation of alcohol-water mixtures.
Sawyer Andrew J - - 2013
Objective. The brain foreign body response (FBR) is an important process that limits the functionality of electrodes that comprise the brain-machine interface. Associated events in this process include leakage of the blood-brain barrier (BBB), reactive astrogliosis, recruitment and activation of microglia, and neuronal degeneration. Proper BBB function is also integral ...
Hara K - - 2013
A prospective clinical study was conducted to evaluate the safety, feasibility, and efficacy of endoscopic ultrasound (EUS)-guided choledochoduodenostomy (CDS) with direct metallic stent placement using a prototype forward-viewing echoendoscope. The indication for EUS - CDS in this study was lower biliary obstruction only, and not failed endoscopic biliary drainage, because the aim ...
Derangula Venkata Ramu - - 2013
A simple, rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method has been developed and fully validated for the simultaneous quantification of tetrabenazine and its active metabolites α-dihydrotetrabenazine and β-dihydrotetrabenazine in human plasma. Tetrabenazine d7 was used as internal standard (IS). The analytes were extracted from 200 μL aliquots ...
Diniz Erik Trovão - - 2013
Objective: Some case reports have suggested an association between primary hyperparathyroidism (PHPT) and peripheral polyneuropathy (PPN). However there are no studies examining this possible relationship. The aim of this study was to evaluate peripheral nerve conduction in subjects with PHPT.Methods: 17 patients with PHTP were included. Mean (±SD) age was ...
Williams Shanna E - - 2013
Edentulism, or tooth loss, seriously alters the appearance of the lower facial skeleton. The aim of this study was to determine if complete maxillary edentulism also impacts the curvature shape of the orbits and zygomatic arches in elderly adults. The study was conducted on 80 crania comprising two cross-sectional populations ...
Qu Min - - 2013
AIMS: EphB2 is a member of receptor tyrosine kinases (RTKs) family that is essential for the cell adhesion, neural crest migration, axon guidance and synaptogenesis in the nervous system. Recent studies show that preservation of EphB2 in a transgenic mouse model of Alzheimer's disease (AD) rescues the cognitive deficit, suggesting ...
Kaucka Markéta - - 2013
The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3 and casein kinase 1 (CK1)-ε are up-regulated in B lymphocytes of patients with chronic ...
Hassanain M - - 2013
BACKGROUND: Postoperative liver dysfunction is the major source of morbidity and mortality in patients undergoing partial hepatectomy. This study tested the benefits of a metabolic support protocol based on insulin infusion, for reducing liver dysfunction following hepatic resection. METHODS: Consecutive consenting patients scheduled for liver resection were randomized to receive ...
Cohen Ricardo Vitor - - 2013
Context:The duodenal-jejunal bypass liner (DJBL) is a device that mimics the intestinal portion of gastric bypass surgery and has been shown to improve glucose metabolism rapidly in obese subjects with type 2 diabetes (T2DM).Objective:To assess the safety of the DJBL and to evaluate its potential to affect glycemic control beneficially ...
Li Jingyi - - 2013
Reliable measurement of DNA concentration is essential for a broad range of applications in biology and molecular biology, and for many of these, quantifying the nucleic acid content is inextricably linked to obtaining optimal results. In its most simplistic form, quantitative analysis of nucleic acids can be accomplished by UV-Vis ...
Blom Kim - - 2013
The live attenuated yellow fever virus (YFV) 17D vaccine provides a good model to study immune responses to an acute viral infection in humans. We studied the temporal dynamics, composition, and character of the primary human T cell response to YFV. The acute YFV-specific effector CD8 T cell response was ...
Bianchini Filippo - - 2013
Recently, developmental topographical disorientation (DTD) was described (Bianchini et al., 2010, J Clin Exp Neuropsychol, 20, 807-27; Iaria & Barton, 2010, Exp Brain Res, 206, 189-96; Iaria, Bogod, Fox, & Barton, 2009, Neuropsychologia, 47, 30-40) as a navigational deficit in the absence of neurological or psychiatric disorders. Here, we reported the ...
Gao Wen - - 2013
Peroxisome proliferator-activated receptor α (PPAR-α) has been detected in the liver, kidney, heart and skeletal muscle. The expression and mechanism of PPAR-α in atherosclerosis remains unclear. The present study was undertaken in order to examine the expression and role of PPAR-α in programmed atherosclerosis induced by a high‑fat diet and balloon-injury ...
Araújo João R - - 2013
Background:The mechanisms whereby gestational diabetes mellitus (GDM) increases the risk of fetal overgrowth and development of metabolic diseases later in life are likely to involve changes in nutrient supply to the fetus. So, in this work we hypothesize that GDM may affect folic acid (FA) supply to the placenta and ...
Wiktorsson Stefan - - 2013
Personality traits have been shown to influence suicidal behaviour but the literature on 'older' elderly is sparse. The aim was to compare neuroticism and extroversion in hospitalized suicide attempters aged 75 and above and a general population comparison group. Seventy-two hospitalized suicide attempters (mean age 81 years) were interviewed. Comparison ...
Dub Pavel A - - 2013
Details of the mechanism of asymmetric transfer hydrogenation of ketones catalyzed by the chiral bifunctional ruthenium complexes, (S)-RuH[(R,R)-OCH(Ph)CH(Ph)NH2](η6-benzene) (Ru-1) and (S)-RuH[(R,R)-p-TsNCH(Ph)CH(Ph)NH2](η6-mesitylene) (Ru-2), were studied computationally by density functional theory with accounting for the solvation effects by using continuum, discrete, and mixed continuum/discrete solvation models via "solvated supermolecules" approach. In contrast ...
Caputo Salvatore - - 2013
Objective: The SOLVE study investigated the initiation of basal insulin in patients with type 2 diabetes on oral antidiabetic (OAD) treatment and outcomes in patients with varying levels of glycemic control at baseline.Methods: This was an observational cohort study conducted in 10 countries, using insulin detemir. Data were collected at ...
Winje Eirin - - 2013
BACKGROUND: Season of birth bias has been observed for people with a number of disorders, including women with bulimia nervosa. However, inconsistent results and methodological weaknesses render previous conclusions about such bias uncertain. With an enhanced methodology, this study aims to test whether there is a season of birth bias ...
Gholami Ameneh - - 2013
The reactions of [Ru(bipy)(2)](2+) with 2-methylpropane, propane, and propene have been investigated in the ICR cell of a mass spectrometer. In these reactions, the association of one molecule of each hydrocarbon was observed. When [Ru(bipy)(2)](2+) was ligated with CO, and the newly formed [Ru(bipy)(2)(CO)](2+) was allowed to react with 2-methylpropane ...
Koenig Alexander - - 2013
ABSTRACT: Several new approaches for treatment of Central Nervous System (CNS) disorders are currently under investigation, including the use of rehabilitation training strategies, which are often combined with electrical and/or pharmacological modulation of spinal locomotor circuitries. While these approaches show great promise in the laboratory setting, there still exists a ...
Rosencher N - - 2013
BACKGROUND: Patients receiving anticoagulants could be at higher risk of compressive haematoma with neuraxial anaesthesia use. The phase III RECORD programme compared rivaroxaban with enoxaparin for prevention of venous thromboembolism after total hip or knee replacement surgery in more than 12,500 patients. This observational analysis evaluated the risk of neuraxial ...
Eiber Calvin D - - 2013
Visual prosthetics is an expanding subfield of functional electrical stimulation which has gained increased interest recently in light of new advances in treatments and technology. These treatments and technology represent a major improvement over prior art, but are still subject to a host of limitations which are dependent on the ...
Yang Wei - - 2013
Perovskite Sr1-xCexCoO3-δ (0.05x0.15) have been prepared by a sol-gel method and studied as cathodes for intermediate temperature solid oxide fuel cells. As SOFC cathodes, Sr1-xCexCoO3- materials have sufficiently high electronic conductivities and excellent chemical compatibility with SDC electrolyte. The peak power density of cells with Sr0.95Ce0.05CoO3-δ is 0.625 W cm-2 ...
Ervinna Nasib - - 2013
Dipeptyl peptidase-4 (DPP-4) inhibitors modulate the progression of atherosclerosis. To gain insights into their mechanism of action, 9-wk-old male apolipoprotein E (apoE)-deficient mice were fed a DPP-4 inhibitor, anagliptin-containing diet. The effects of anagliptin were investigated in, a monocyte cell line, human THP-1 cells, and rat smooth muscle cells (SMCs). ...
Portmann Simone - - 2013
Sirtuins (SIRT1-7) are a highly conserved family of NAD+ dependent enzymes that control the activity of histone and non-histone regulatory proteins. SIRT1 is known to promote longevity and to suppress the initiation of some cancers. Nevertheless, SIRT1 is reported to function as a tumor suppressor as well as an oncogenic ...
Vamos Szonja - - 2013
Abstract Relationship quality and partner dynamics provide important insights into understanding sexual behavior within HIV sero-positive and sero-discordant couples. Individuals in long-term partnerships may be vulnerable to HIV/sexually transmitted infections (STI) within their relationships due to misperceptions of their partners risk behaviors and potential concurrent (e.g., extramarital, nonprimary) sexual partnerships. ...
Gosmanov Aidar R - - 2013
Objective: To compare the response to different insulin regimens for management of hyperglycemia in diabetic patients with hematological malignancies receiving dexamethasone.Methods: Retrospective analysis to determine whether basal bolus insulin (BBI) regimen with detemir and aspart is superior to the use of sliding scale regular insulin (SSI) in the management of ...
Tien Wei-Sheng - - 2013
The identification of secreted protein markers has been receiving great attention as part of the trend toward non-invasive biomarker discovery. In addition, certain cell membrane proteins are known to be released into the extracellular milieu via ectodomain shedding. As membrane proteins play an essential role in signaling pathways and because ...
Dompnier Benoît - - 2013
Research on achievement goal promotion at University has shown that performance-approach goals are perceived as a means to succeed at University (high social utility) but are not appreciated (low social desirability). We argue that such a paradox could explain why research has detected that performance-approach goals consistently predict academic grades. ...
Misra A - - 2013
Objective. The aim of this study was to test the efficacy of Poloxamer P188 to reduce cell death and immune response associated with mechanical trauma to cells during implantation of a chronic recording electrode. Approach. Ceramic multi-site recording electrodes were implanted bilaterally into 15 adult male Long-Evans rats. One of ...
Danescu Liviu G - - 2013
Objective: To compare the use of photoplethysmography (PPG) and Doppler techniques to measure the Ankle Brachial Index (ABI) for the evaluation of peripheral arterial disease (PAD) in individuals with diabetes.Methods: Consecutive patients with diabetes (n=103) referred for PAD evaluation had ABI measured by PPG and Doppler techniques in our diabetes ...
Dogliotti Ariel - - 2013
BACKGROUND: Warfarin reduces ischemic stroke in atrial fibrillation, but has numerous limitations. Novel oral anticoagulants provide more predictable anticoagulation with fewer shortcomings. HYPOTHESIS: Novel oral anticoagulants are superior to warfarin to prevent stroke or systemic embolism. METHODS: Phase III randomized warfarin-controlled trials enrolling >3000 patients that reported clinical efficacy and ...
Giménez-Milà Marc - - 2013
We report a case of a 73-year-old female who developed unbearable neuropathic pain after a herpes zoster episode. The pain persisted and could not be controlled despite multimodal analgesia. In addition to postherpetic neuralgia, myelitis and complex regional pain syndrome were diagnosed during the evolution of neuropathic pain. This complex ...
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