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Eiber Calvin D - - 2013
Visual prosthetics is an expanding subfield of functional electrical stimulation which has gained increased interest recently in light of new advances in treatments and technology. These treatments and technology represent a major improvement over prior art, but are still subject to a host of limitations which are dependent on the ...
Yang Wei - - 2013
Perovskite Sr1-xCexCoO3-δ (0.05x0.15) have been prepared by a sol-gel method and studied as cathodes for intermediate temperature solid oxide fuel cells. As SOFC cathodes, Sr1-xCexCoO3- materials have sufficiently high electronic conductivities and excellent chemical compatibility with SDC electrolyte. The peak power density of cells with Sr0.95Ce0.05CoO3-δ is 0.625 W cm-2 ...
Cottarel Jessica - - 2013
Nonhomologous end joining is the primary deoxyribonucleic acid (DNA) double-strand break repair pathway in multicellular eukaryotes. To initiate repair, Ku binds DNA ends and recruits the DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs) forming the holoenzyme. Early end synapsis is associated with kinase autophosphorylation. The XRCC4 (X4)-DNA Ligase IV (LIG4) ...
Hirata Akimasa - - 2013
According to the international safety guidelines/standard, the whole-body-averaged specific absorption rate (Poljak et al 2003 IEEE Trans. Electromagn. Compat. 45 141-5) and the peak spatial average SAR are used as metrics for human protection from whole-body and localized exposures, respectively. The IEEE standard (IEEE 2006 IEEE C95.1) indicates that the ...
Whiteman Pat P Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United - - 2013
We have mapped a Jagged/Serrate-binding site to specific residues within the 12th EGF domain of human and Drosophila Notch. Two critical residues, involved in a hydrophobic interaction, provide a ligand-binding platform and are adjacent to a Fringe-sensitive residue that modulates Notch activity. Our data suggest that small variations within the ...
Miclescu Adriana A - - 2013
Cytokines and oxygen free radicals have been implicated in the potential pathogenic development of complex regional pain syndrome (CRPS). We aimed to analyze the relationship between clinical status, circulating levels of cytokines, and markers of oxidative damage during the treatment with anti-TNFα antibodies. The patient chosen for treatment had not ...
Barsuk Jeffrey H - - 2013
Despite the widespread use of loop diuretics to treat acute decompensated heart failure (ADHF), robust data supporting their role and optimal dosing strategies are scarce. This analysis aimed to compare clinical outcomes of patients admitted with ADHF who received a diuretic dosing protocol with those who received the usual diuretic ...
Jiang Zhou - - 2013
An HPLC system combining a chemiluminescence detector was applied to estimate the singlet oxygen ((1) O(2) ) generation ability of di-sulfonic phthalocyanine zinc (ZnPcS(2) ) isomers. As photosensitizers, ZnPcS(2) produces (1) O(2) in air-saturated solutions under photoirradiation. The latter reacts with methyl Cypridina luciferin analogue (MCLA) to initiate chemiluminescence. This ...
Nguyen David H DH Department of Radiation Oncology, New York University School of Medicine, New York, New York 10016, - - 2013
Ionizing radiation is a well-established carcinogen in rodent models and a risk factor associated with human cancer. We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53-null mammary tissue to sham or irradiated hosts. Gene expression profiles of tumors that arose in irradiated mice ...
De Volder Michaël - - 2013
Surfaces coated with nanoscale filaments such as silicon nanowires and carbon nanotubes are potentially compelling for high-performance battery and capacitor electrodes, photovoltaics, electrical interconnects, substrates for engineered cell growth, dry adhesives, and other smart materials. However, many of these applications require a wet environment or involve wet processing during their ...
Kulkarni A - - 2013
Metal-pernitride compounds belong to a class of chemical systems in which both the complex ions and the non-bonding electrons may play roles in the formation of their modified crystalline structures. To investigate this issue, the energy landscapes of pernitrides of metals with different maximum valence (M=Ca, Sr, Ba, La, and ...
Orci L A - - 2013
BACKGROUND: Several therapeutic strategies, such as ischaemic preconditioning, intermittent or selective pedicle clamping and pharmacological interventions, have been explored to reduce morbidity caused by hepatic ischaemia-reperfusion injury and the surgical stress response. The role of steroids in this setting remains controversial. METHODS: A comprehensive literature search in MEDLINE, Embase and ...
Kaptein Elaine M - - 2013
Objective: To determine prevalence of 25(OH) D deficiency in ambulatory and hospitalized patients from a large urban county medical center in Southern California. To assess effects of season, ethnicity, age, location of care, and co-morbidities on prevalence.Methods: We retrieved all serum 25(OH) D2 and D3 concentrations measured during 2010 from ...
Garb Jessica E JE Department of Biological Sciences, University of Massachusetts, Lowell, USA. - - 2013
Black widow spiders (members of the genus Latrodectus) are widely feared because of their potent neurotoxic venom. α-Latrotoxin is the vertebrate-specific toxin responsible for the dramatic effects of black widow envenomation. The evolution of this toxin is enigmatic because only two α-latrotoxin sequences are known. In this study, ~4 kb ...
Batsikadze G G Department of Clinical Neurophysiology, University of Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, - - 2013
Transcranial direct current stimulation (tDCS) of the human motor cortex at an intensity of 1 mA with an electrode size of 35 cm(2) has been shown to induce shifts of cortical excitability during and after stimulation. These shifts are polarity-specific with cathodal tDCS resulting in a decrease and anodal stimulation ...
Ogunsiji Olayide - - 2013
AIMS AND OBJECTIVES: To explore West African migrant women's knowledge, attitude and usage of cancer screening in Australia. BACKGROUND: Despite strong evidence that cancer screening saves lives through early detection and treatment, there is lack of empirical studies on West African migrant women's knowledge, attitude and usage of cancer screening ...
Zhou Dingying D Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794-8175, - - 2013
We have synthesized a novel derivative of indomethacin, phospho-tyrosol-indomethacin (PTI; MPI-621), and evaluated its anticancer efficacy in vitro and in vivo. PTI inhibited the growth of human colon, breast and lung cancer cell lines 6-30-fold more potently than indomethacin. In vivo, in contrast to indomethacin that was unable to inhibit ...
Choi Sungjin - - 2013
In this study, we aimed to determine the effect of trehalose coating and the optimal dose of basic fibroblast growth factor (bFGF), an osteoinductive protein, loaded onto tailor-made bone implants for implant-induced bone formation in vivo. We fabricated tailor-made α-tricalcium phosphate bone implants (11 mm diameter with 2 parallel cylindrical ...
Peurala Emmi - - 2013
ABSTRACT: INTRODUCTION: Loss of the retinoblastoma protein tumor suppressor gene (RB) coding for a nuclear phosphoprotein that regulates the cell cycle is found in many human cancers and probably leads to disruption of the p16-cyclin D1-CDK4/6-RB pathway. Cyclin D1 is known to activate CDK4, which then phosphorylates the RB protein, ...
Bozkurt Nujen Colak - - 2013
Objective: The relation between vitamin-D and autoimmune disorders has long been investigated regarding to important roles of this hormone in immune regulation. We evaluated 25-hydroxy-vitamin-D (25OHD) status of subjects with Hashimoto's thyroiditis (HT) and healthy controls.Methods: Group-1 consisted of 180 euthyroid patients (123 females/57 males) with HT who were on ...
Waghray Abhijeet - - 2013
Objective: To present a case series on biotin interference in parathyroid hormone level measurement.Methods: We review the presentation and management of patients at our institution evaluated for unexpectedly low parathyroid hormone levels while taking biotin supplements in the setting of high or normal serum calcium.Results: Two patients presented with surprising ...
Yang Chiao-Wen CW Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, - - 2013
Neutrophils are obligate cells entering lymph nodes shortly after immunization with protein antigens in adjuvants, starting during the first hour and continuing for several days in two distinct waves. Previously, we demonstrated the strong suppressive effects of neutrophils on CD4 T cell and B cell responses, using either neutrophil-depleting antibodies ...
Han Jinbo J Moores UCSD Cancer Center, University of California San Diego, La Jolla, California 92093, - - 2013
Tumor necrosis factor (TNF)-α promotes tumor development under chronic inflammation. Because TNF also activates caspase-8, selective inhibition of TNF-induced extrinsic apoptosis would be required for inflammation-associated tumor growth. In a mouse model of inflammation-associated colon carcinogenesis, we found nuclear expression of β-catenin in tumors of wild-type, but not mutant, mice ...
Lundgren Rylan J RJ Division of Chemistry and Chemical Engineering, California, Institute of Technology, Pasadena, CA 91125, - - 2013
Pin the amine on the gamma: A new method has been developed for the γ-addition of nitrogen nucleophiles to γ-substituted alkynoates or allenoates through intra- and intermolecular processes that are catalyzed by spirophosphine 1. An asymmetric version of this reaction affords enantioenriched pyrrolidines, indolines, and γ-amino-α,β-unsaturated carbonyl compounds.
Kampondeni Sam D SD Blantyre Malaria Project, Blantyre, Malawi. - - 2013
Abstract. A prospective cohort study of retinopathy-confirmed cerebral malaria (CM) survivors identified 42 of 132 with neurologic sequelae. The 38 survivors with sequelae who were alive when magnetic resonance imaging (MRI) technology became available underwent brain MRIs. Common MRI abnormalities included periventricular T2 signal changes (53%), atrophy (47%), subcortical T2 ...
Kupari Jussi J Institute of Biomedicine, Anatomy, Biomedicum Helsinki, University of Helsinki, Helsinki, - - 2013
Efferent signals from the vagus nerve are thought to mediate both basal and meal-induced gastric acid secretion, and provide trophic support of the mucosa. However, the underlying mechanisms are incompletely understood. Neurturin, signalling via glial cell line-derived neurotrophic factor (GDNF)-family receptor α2 (GFRα2), is essential for parasympathetic innervation of many ...
Liu Rui - - 2013
A series of Pt(ii) bipyridyl complexes with different aryl substituents (Ar = naphthyl (), anthryl (), pyrenyl () and phenothiazyl ()) on the fluorenylacetylide ligands are synthesized and investigated. The influence of the aryl substituent on the photophysics of these complexes is systematically investigated by spectroscopic methods and simulated by ...
Masica David L DL Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, - - 2013
Computational analysis of cancer pharmacogenomics data has resulted in biomarkers predictive of drug response, but the majority of response is not captured by current methods. Methods typically select single biomarkers or groups of related biomarkers but do not account for response that is strictly dependent on many simultaneous genetic alterations. ...
Martin-Loeches Ignacio - - 2013
ABSTRACT: The optimal length of antimicrobial therapy has not been extensively studied for a great majority of infections and, in critically ill patients affected by ventilator-associated pneumonia, is a persisting and unsolved issue confronting clinicians. The integration of biomarkers, clinical judgment, and microbiologic eradication might help to define a shorter ...
Li Yaohang - - 2013
The rapidly increasing number of protein crystal structures available in PDB has naturally made statistical analyses feasible in studying complex high-order inter-residue correlations. In this paper, we report a Context-based Secondary Structure Potential (CSSP) for assessing the quality of predicted protein secondary structures generated by various prediction servers. CSSP is ...
Richter Günther Hs - - 2013
Metastatic spread in Ewing sarcomas (ES) is frequent and haematogenous. G-protein coupled receptor 64 (GPR64), an orphan receptor with normal expression restricted to human epididymis is specifically over-expressed in ES among sarcoma, but also up-regulated in a number of carcinomas derived from prostate, kidney or lung. Inhibition of GPR64 expression ...
Ervinna Nasib - - 2013
Dipeptyl peptidase-4 (DPP-4) inhibitors modulate the progression of atherosclerosis. To gain insights into their mechanism of action, 9-wk-old male apolipoprotein E (apoE)-deficient mice were fed a DPP-4 inhibitor, anagliptin-containing diet. The effects of anagliptin were investigated in, a monocyte cell line, human THP-1 cells, and rat smooth muscle cells (SMCs). ...
Portmann Simone - - 2013
Sirtuins (SIRT1-7) are a highly conserved family of NAD+ dependent enzymes that control the activity of histone and non-histone regulatory proteins. SIRT1 is known to promote longevity and to suppress the initiation of some cancers. Nevertheless, SIRT1 is reported to function as a tumor suppressor as well as an oncogenic ...
Lomax Geoffrey P - - 2013
ABSTRACT: Efforts have emerged internationally to recruit donors with specific disease indications and to derive induced pluripotent cell lines. These disease-specific induced pluripotent stem cell lines have the potential to accelerate translational goals such as drug discovery and testing. One consideration for donor recruitment and informed consent is the possibility ...
Gosmanov Aidar R - - 2013
Objective: To compare the response to different insulin regimens for management of hyperglycemia in diabetic patients with hematological malignancies receiving dexamethasone.Methods: Retrospective analysis to determine whether basal bolus insulin (BBI) regimen with detemir and aspart is superior to the use of sliding scale regular insulin (SSI) in the management of ...
Boomsma Jacobus J JJ Centre for Social Evolution, Department of Biology, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark. - - 2013
Obligate eusociality with distinct caste phenotypes has evolved from strictly monogamous sub-social ancestors in ants, some bees, some wasps and some termites. This implies that no lineage reached the most advanced form of social breeding, unless helpers at the nest gained indirect fitness values via siblings that were identical to ...
Gürgen Dennis - - 2013
The deoxycorticosterone acetate (DOCA)-salt mouse model exhibits adverse cardiac remodeling in male mice and cardiac protection in female mice, even when blood pressure is normalized. We hypothesized that intact mammalian target of rapamycin (mTOR) signaling is necessary for cardiac protection in females. We first tested sex differences and intracellular signaling ...
Myers Lynn - - 2013
This study investigated the effect of a smoking health message on smokers' comparative optimism. Two groups watched an anti-smoking scenario, with one group imagining being part of the scenario. Participants, including controls, completed comparative optimism ratings for four smoking-related illnesses. The intervention had negative consequences with both intervention groups reporting ...
Harikrishnan R - - 2013
The present study was undertaken to elucidate the effect of ascorbic acid on alcohol-induced reproductive toxicity and also to compare it with that of abstention. A total of thirty-six male guinea pigs were divided into two groups and were maintained for 90 d as control and ethanol-treated groups (4 g/kg body weight ...
Dalton Lucy E - - 2013
Deregulated Ras signalling initiates and maintains melanocyte neoplasia. The Rho-like GTPase Rac has been implicated in Ras-induced neoplastic transformation. Moreover, a recurrent UV-induced mutation activating RAC1 has recently been detected in human melanoma. Here, a role for Rac in melanoma initiation and progression was investigated in human melanomas and zebrafish ...
Vanhoestenberghe A - - 2013
Electrode mounts are being developed to improve electrical stimulation and recording. Some are tight-fitting, or even re-shape the nervous structure they interact with, for a more selective, fascicular, access. If these are to be successfully used chronically with human nerve roots, we need to know more about the possible damage ...
Ribeiro António E - - 2013
The separation of the four nadolol stereoisomers on Chiralpak® AD by chiral liquid chromatography was carried out at both analytical and preparative scales. A screening of possible mobile-phase compositions was performed using different alcohol-hydrocarbon mixtures. The results obtained confirm the use of 20:80:0.3 ethanol-hexane-diethylamine reported by McCarthy (1994) but introduce ...
Wonderlich Elizabeth R ER Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA 15261, - - 2013
The role of mononuclear phagocytes in the pathogenesis or control of HIV infection is unclear. In this study, we monitored the dynamics and function of dendritic cells (DC) and monocytes/macrophages in rhesus macaques acutely infected with pathogenic SIVmac251 with and without antiretroviral therapy (ART). SIV infection was associated with monocyte ...
Gad Parag - - 2013
ABSTRACT: BACKGROUND: Stimulation of the spinal cord has been shown to have great potential for improving function after motor deficits caused by injury or pathological conditions. Using a wide range of animal models, many studies have shown that stimulation applied to the neural networks intrinsic to the spinal cord can ...
Tien Wei-Sheng - - 2013
The identification of secreted protein markers has been receiving great attention as part of the trend toward non-invasive biomarker discovery. In addition, certain cell membrane proteins are known to be released into the extracellular milieu via ectodomain shedding. As membrane proteins play an essential role in signaling pathways and because ...
Dompnier Benoît - - 2013
Research on achievement goal promotion at University has shown that performance-approach goals are perceived as a means to succeed at University (high social utility) but are not appreciated (low social desirability). We argue that such a paradox could explain why research has detected that performance-approach goals consistently predict academic grades. ...
Misra A - - 2013
Objective. The aim of this study was to test the efficacy of Poloxamer P188 to reduce cell death and immune response associated with mechanical trauma to cells during implantation of a chronic recording electrode. Approach. Ceramic multi-site recording electrodes were implanted bilaterally into 15 adult male Long-Evans rats. One of ...
Danescu Liviu G - - 2013
Objective: To compare the use of photoplethysmography (PPG) and Doppler techniques to measure the Ankle Brachial Index (ABI) for the evaluation of peripheral arterial disease (PAD) in individuals with diabetes.Methods: Consecutive patients with diabetes (n=103) referred for PAD evaluation had ABI measured by PPG and Doppler techniques in our diabetes ...
Dogliotti Ariel - - 2013
BACKGROUND: Warfarin reduces ischemic stroke in atrial fibrillation, but has numerous limitations. Novel oral anticoagulants provide more predictable anticoagulation with fewer shortcomings. HYPOTHESIS: Novel oral anticoagulants are superior to warfarin to prevent stroke or systemic embolism. METHODS: Phase III randomized warfarin-controlled trials enrolling >3000 patients that reported clinical efficacy and ...
Pop Sorin - - 2013
MOTIVATION: In developmental biology, quantitative tools to extract features from fluorescence microscopy images are becoming essential to characterize organ morphogenesis at the cellular level. However, automated image analysis in this context is a challenging task, due to perturbations induced by the acquisition process, especially in organisms where the tissue is ...
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