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Qi Xin - - 2013
ABSTRACT - Purpose. To compare the properties of buccal delivery matrices (wafers) made with dextrin, β-limit dextrin and pre-gelatinised starch. Methods. The constituent α-glucans were tested for their mucoadhesive properties in solution plus their content of crystalline material (differential scanning calorimetry, DSC). Wafers were made by lyophilisation of aqueous solutions/dispersions ...
Miller Ted T Pacific Institute for Research and Evaluation, 11720 Beltsville Drive, Suite 900, Beltsville, MD 20705, USA. - - 2013
This cost-effectiveness study analyzes the cost per quality-adjusted life year (QALY) gained in a randomized controlled trial that tested school support as a structural intervention to prevent HIV risk factors among Zimbabwe orphan girl adolescents. The intervention significantly reduced early marriage, increased years of schooling completed, and increased health-related quality ...
Chtarto Abdelwahed A Laboratory of Experimental Neurosurgery, Free University of Brussels (ULB), Brussels, - - 2013
Recombinant adeno-associated virus (rAAV) vectors mediating long term transgene expression are excellent gene therapy tools for chronic neurological diseases. While rAAV2 was the first serotype tested in the clinics, more efficient vectors derived from the rh10 serotype are currently being evaluated and other serotypes are likely to be tested in ...
Segal Barbara M BM Hennepin County Medical Center and University of Minnesota, Minneapolis, MN 55415, USA. - - 2013
To compare clinical characteristics and patient-reported outcomes in seropositive versus seronegative primary Sjögren's syndrome (SS) patients and to investigate the effect of serologic status on the prevalence of chronic pain, comorbidity, and health quality. Pain severity and neuropathic pain symptoms, comorbidity, and health status were assessed in 108 primary SS ...
Faje Alexander T AT Neuroendocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, Boston, MA 02114, - - 2013
Adolescents with anorexia nervosa (AN) are amenorrheic and have decreased bone mass accrual and low bone mineral density (BMD). The regulation of mesenchymal stem cell differentiation is an important factor governing bone formation. Preadipocyte factor 1 (Pref-1), an inhibitor of adipocyte and osteoblast differentiation, is elevated in states of oestrogen ...
Singh Jasvinder A JA Birmingham VA Medical Center. - - 2013
Total knee arthroplasty (TKA) is a widely utilized and effective treatment option for end-stage knee osteoarthritis (OA). Knee OA is more prevalent among women compared to men, but there are limited data on the sex differences in surgical outcomes after primary TKA. Our sample consisted of all primary TKAs performed ...
Karalunas Sarah L SL ADHD Research Study, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239-9979, USA. - - 2013
Using Ratcliff's diffusion model and ex-Gaussian decomposition, we directly evaluate the role individual differences in reaction time (RT) distribution components play in the prediction of inhibitory control and working memory (WM) capacity in children with and without ADHD. Children with (n = 91, [Formula: see text] age = 10.2 years, 67 % male) and without ADHD ...
Ochoa Manuel M School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA. - - 2013
In this paper, we report on a cost effective and simple method for fabricating a flexible multi-electrode array for subdural neural recording. The electrode was fabricated using a PDMS-Parylene bilayer to combine the major advantages of both materials. Mechanical and electrical characterizations were performed to confirm functionality of a 16-site ...
Lai Y-T YT Department of Physical Medicine and Rehabilitation, Sijhih Cathay General Hospital, New Taipei, - - 2013
While the chronic inflammation related to autoimmune diseases is known to be associated with an increased cardiovascular risk, much less is known about cerebrovascular risks. The present population-based, age- and sex-matched follow-up study was undertaken to investigate the risks of acute myocardial infarction (AMI) and ischaemic stroke in patients with ...
Christmann Romy B RB Boston University School of Medicine, Boston, Massachusetts 02118-2526, USA. - - 2013
To explore the expression of thymic stromal lymphopoietin (TSLP) in patients with diffuse cutaneous systemic sclerosis (dcSSc) and compare its effects in vivo and in vitro with those of interleukin-13 (IL-13) and transforming growth factor β (TGFβ). Skin biopsy specimens from patients with dcSSc (n = 14) and healthy controls ...
Richardson Barbra A BA Department of Biostatistics, University of Washington, Seattle, WA 98104-2499, USA. - - 2013
To compare the 2 control arms of HPTN 035 [a hydroxyethylcellulose (HEC) gel control arm and a no-gel control arm] to assess the behavioral effects associated with gel use and direct causal effects of the HEC gel on sexually transmitted infections (STIs), pregnancy, and genital safety. Randomized trial with 1 ...
Sluka Kathleen A KA Department of Physical Therapy and Rehabilitation Science, University of Iowa Carver College of Medicine, Iowa City 52242, USA. - - 2013
Through its location on nociceptors, acid-sensing ion channel 3 (ASIC-3) is activated by decreases in pH and plays a significant role in musculoskeletal pain. We recently showed that decreases in pH activate ASIC-3 located on fibroblast-like synoviocytes (FLS), which are key cells in the inflammatory process. The purpose of this ...
Stanford Stephanie M SM La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, - - 2013
The fibroblast-like synoviocytes (FLS) in the synovial intimal lining of the joint are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA, these cells aggressively invade the extracellular matrix, producing cartilage-degrading proteases and inflammatory cytokines. The behavior of FLS is controlled by multiple interconnected signal transduction ...
Alçin E E Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, PA, - - 2013
Tonic gonadotrophin secretion throughout the menstrual cycle is regulated by the negative-feedback actions of ovarian oestradiol (E₂) and progesterone. Although kisspeptin neurones in the arcuate nucleus (ARC) of the hypothalamus appear to play a major role in mediating these feedback actions of the steroids in nonprimate species, this issue has ...
Dinglasan R R RR W Harry Feinstone Department of Molecular Microbiology & Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. - - 2013
Malaria sexual stage and mosquito transmission-blocking vaccines (SSM-TBV) have recently gained prominence as a necessary tool for malaria eradication. SSM-TBVs are unique in that, with the exception of parasite gametocyte antigens, they primarily target parasite or mosquito midgut surface antigens expressed only inside the mosquito. As such, the primary perceived ...
Scott Daniel D Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536-0596, - - 2013
Mithramycin (MTM) is a potent anti-cancer agent that has recently garnered renewed attention. This manuscript describes the design and development of mithramycin derivatives through a combinational approach of biosynthetic analogue generation followed by synthetic manipulation for further derivatization. Mithramycin SA is a previously discovered analogue produced by the M7W1 mutant ...
Schreier Wolfgang J - - 2013
The intramolecular and intermolecular vibrational energy flow in a polyproline peptide with a total number of nine amino acids in the solvent dimethyl sulfoxide is investigated using time-resolved infrared (IR) spectroscopy. Azobenzene covalently bound to a proline sequence containing nitrophenylalanine as a local sensor for vibrational excess energy serves as ...
Kawatsu Tsutomu - - 2013
Electron and excitation energy transfers (ET and EET) have an important role in biological energy-exchange processes. Proteins are an inhomogeneous and anisotropic medium for ET and EET. The protein structure influences electronic coupling, an important factor for ET and EET. The structure factor may be predicted by obtaining information about ...
Skourtis Spiros S - - 2013
The mechanisms of bridge-mediated electron transfer (ET) reactions vary from coherent deep tunneling to thermally activated hopping. This short review focuses on some developments in the study of protein ET mechanisms at the molecular and at the cellular levels. It explains experimental and theoretical work on the influence of electronic-energy ...
Lettieri Raffaella - - 2013
The elusive, multiple fully extended (2.0(5) -helix) peptide conformation was searched with a series of C(α,α) -diethylglycine homo-oligomers (n = 1 to 5) functionalized by an electron transfer (ET) donor···acceptor (D···A) pair in acetonitrile and chloroform solutions. In the former solvent, all peptides investigated were shown to populate the 3(10) ...
Bandi Swati - - 2013
Intermolecular electron transfer (ET) between hexaamineruthenium(II), a(6) Ru(2+) , and a K73H/K79A variant of iso-1-cytochrome c, iso-1-Cytc, is used to study conformational ET switches mediated by His73-heme ligation and cis to trans isomerization of the Ile75-Pro76 peptidyl-prolyl bond of iso-1-Cytc. The biomolecular rate constant for ET to the native state ...
Sek Slawomir - - 2013
Development of molecular scale electronics stimulates the search for new functional materials and compounds. One of the promising directions of further growth within this field is bioelectronics, which assumes the use of electron transfer (ET)-mediating properties of bio-related compounds. Because of the structural and functional versatility, peptides and proteins are ...
Moritoh Ryosuke - - 2013
In this study, we construct photoenergy-conversion systems with chromophores located with molecular precision to facilitate efficient light harvesting and charge transport. 3(10) -Helical peptides carrying a disulfide group at the N-terminal, linearly arranged six naphthyl groups at the side chains, and an energy acceptor (anthryl, pyrenyl, or N-ethylcarbazolyl group) at ...
Donoli Alessandro - - 2013
In this article, the successful preparation of a new series of 3(10) -helical peptides of different length containing two terminal ferrocenyl (Fc) units and based on the strongly foldameric α-aminoisobutyric (Aib) acid is reported. The synthesis of the FcCO(Aib)(n) NHFc (n = 1-5) homo-peptides was performed by solution methods. Moderate ...
Atanassov Alexander - - 2013
Studies of charge transport through proteins bridged between two electrodes have been the subject of intense research in recent years. However, the complex structure of proteins makes it difficult to elucidate transport mechanisms, and the use of simple peptide oligomers may be an over simplified model of the proteins. To ...
Hanson Kenneth - - 2013
The performance of dye-sensitized solar and photoelectrochemical cells is strongly dependent on the electron transfer events at the electrode-sensitizer interface. Surface-bound peptides derivatized with chromophores have not been used in dye-sensitized solar and photoelectrochemical cells, but they have properties for these applications that could be advantageous by exploiting secondary structure ...
Kitamatsu Mizuki - - 2013
In this report, we describe dendritic peptides possessing central fluorescent amino acids with adjacent branched amino acids. These fluorescent-peptide dendrimers were prepared using (9-fluorenyl)methoxycarbonyl (Fmoc)-based solid-phase peptide synthesis and Fmoc-derivative fluorescent and branched amino acids. The branched amino acids featured multiple carboxylic acids in their side chains, making the fluorescent-peptide ...
Hansson Sara F - - 2013
Current or recent enteroviral infections show an association with type 1 diabetes. However, evidence for this has mainly been generated using a particular mouse monoclonal antibody (clone 5-D8/1) which binds the viral capsid protein VP1. Difficulty in confirming these findings using other independent methods has led to the concern that ...
Peretz H H Clinical Biochemistry Laboratory, Sourasky Medical Center, Tel Aviv, Israel. - - 2013
Factor XI (FXI) deficiency is one of the most frequent inherited disorders in Ashkenazi Jews (AJ). Two predominant founder mutations termed type II (p.Glu117Stop) and type III (p.Phe283Leu) account for most cases. To present clinical aspects of a third FXI mutation, type I (c.1716 + 1G>A), which is also prevalent in AJ ...
Parry Lee L School of Bioscience Biosciences, Cardiff University, Cardiff, United - - 2013
The identification of the intestinal stem cell (ISC) markers Lgr5 and Bmi-1 has furthered our understanding of how they accomplish homeostasis in this rapidly self-renewing tissue. Recent work indicates that these markers identify a cycling Lgr5(+) ISC which can be replaced by a quiescent Bmi-1(+) ISC. Currently, there is little ...
Liang Xiaoliang X Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, - - 2013
Lung epithelial cell death is a prominent feature of hyperoxic lung injury, and has been considered a very important underlying mechanism of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Here we report on a novel mechanism involved in epithelial cytoprotection and homeostasis after oxidative stress. p62 (sequestosome ...
Dougherty Paul J PJ Detroit Medical Center, 4201 St Antoine St #404, Detroit, MI 48201, USA. - - 2013
This CORR Insights™ is a commentary on the article "Intramedullary Nails Result in More Reoperations Than Sliding Hip Screws in Two-part Intertrochanteric Fractures" by Matre et al. available at DOI- 10.1007/s11999-012-2728-2 .
Sarkar Sujata S Department of Medicine, Arizona Arthritis Center, University of Arizona, 1501 North Campbell Avenue, AHSC Rm 6309, Tucson, AZ 85724, USA. - - 2013
The mechanism of action of interleukin- 22 (IL-22) in inflammatory arthritis remains unknown. IL-22-deficient mice exhibit an intact humoral and cellular immune response to collagen and yet have a reduced incidence of collagen-induced arthritis (CIA). Further, administration of anti-IL-22 does not reduce the severity of clinical arthritis but rather improves ...
St Clair E William EW Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. - - 2013
To study the safety and clinical efficacy of rituximab therapy for primary Sjögren's syndrome, as well as to investigate its mechanisms. Patients with primary Sjögren's syndrome were enrolled in an open-label trial, were given rituximab (1 gm) infusions on days 1 and 15, and were monitored through week 52. The ...
Kirchhoff B A BA Department of Psychology, University of Missouri - St. Louis, St. Louis, MO, - - 2013
Hypoglycaemic events can be a serious complication of insulin therapy in Type 1 diabetes mellitus. Severe hypoglycaemic exposure can lead to episodic memory impairments, including anterograde amnesia. However, relatively little is known regarding the long-term impact of severe hypoglycaemia on brain structure in Type 1 diabetes mellitus. The goals of ...
Wang Yi-Xiang J YX Department of Imaging and Interventional Radiology, Chinese University of Hong Kong and Prince of Wales Hospital, Shatin, Hong Kong, China. - - 2013
Osteoporotic Fractures in Men (Hong Kong) and Osteoporotic Fractures in Women (Hong Kong) represent the first large-scale prospective population-based studies on bone health in elderly (age≥65 years) Chinese men (n=2,000) and women (n=2,000). We undertook the current study to investigate the prevalence of lumbar disc space narrowing in these subjects, ...
Lee Angela A Hospital for Special Surgery and Weill Cornell Graduate School of Medical Sciences, New York, New York 10021, - - 2013
The nonresolving character of synovial inflammation in rheumatoid arthritis (RA) is a conundrum. To identify the contribution of fibroblast-like synoviocytes (FLS) to the perpetuation of synovitis, we investigated the molecular mechanisms that govern the tumor necrosis factor α (TNFα)-driven inflammatory program in human FLS. FLS obtained from the synovial tissues ...
Phillips Frank M FM Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA. - - 2013
Systematic literature review. To categorize published evidence systematically for lumbar fusion for chronic low back pain (LBP) in order to provide an updated and comprehensive analysis of the clinical outcomes. Despite a large number of publications of outcomes of spinal fusion surgery for chronic LBP, there is little consensus on ...
Zhang Yan Ping YP Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, Florida 33101-6370, - - 2013
Oxidative stress is a key factor implicated in the development of diabetic neuropathy. This study evaluates the prophylactic and antinociceptive effects of the antioxidant coenzyme Q10 (CoQ10) on diabetes-induced neuropathic pain in a diabetic mouse model. Total 56 mice with type 1 diabetes induced by streptozotocin were used, 20 normal ...
Jacob Chaim O CO University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA. - - 2013
To determine the necessity for any individual BAFF receptor in the development of systemic lupus erythematosus (SLE). Bcma-, Taci-, and Br3-null mutations were introgressed into NZM 2328 mice. NZM.Bcma-/-, NZM.Taci-/-, and NZM.Br3-/- mice were evaluated for lymphocyte phenotype and BAFF receptor expression by flow cytometry; for B cell responsiveness to ...
Szabo Akos Z AZ Department of Dermatology, University of California San Francisco and Veteran Affairs Medical Center, Dermatology Service, San Francisco, California, - - 2013
Like for other somatic tissues, isolation of a pure population of stem cells has been a primary goal in epidermal biology. We isolated discrete populations of freshly obtained human neonatal keratinocytes (HNKs) using previously untested candidate stem cell markers aldehyde dehydrogenase (ALDH) and CD44 as well as the previously studied ...
Ohashi Yasuo - - 2013
Erythropoiesis-stimulating agents (ESA) reduce the need for transfusions and improve the quality of life in patients receiving chemotherapy, but several clinical trials have suggested that ESA might have a negative impact on survival. To evaluate the efficacy and safety of ESA, epoetin beta and darbepoetin alfa, including their impact on ...
Lorincz Attila T AT Queen Mary University of London, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine, London, EC1M 6BQ, United Kingdom. - - 2013
DNA methylation changes in human papillomavirus type 16 (HPV16) DNA are common and might be important for identifying women at increased risk of cervical cancer. Using recently published data from Costa Rica we developed a classification score to differentiate women with cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3) from ...
Helfer Emmanuèle E Centre de Recherche de Gif, Laboratoire d'Enzymologie et Biochimie Structurales, CNRS UPR3082, Avenue de la Terrasse, Gif-sur-Yvette Cedex 91198, - - 2013
The Wiskott-Aldrich syndrome protein and scar homolog (WASH) complex is the major Arp2/3 activator at the surface of endosomes. The branched actin network, that the WASH complex induces, contributes to cargo sorting and scission of transport intermediates destined for most endosomal routes. A major challenge is to understand how the ...
Lee Jeong Goo JG Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, - - 2013
Interleukin (IL)-1β is a major pro-inflammatory cytokine that plays a crucial role in the regulation of inflammation and wound healing in the cornea. Elucidation of IL-1β signalling may help identify therapeutic targets for corneal wound healing; however, mechanisms such as cell migration, a component of IL-1β-induced wound healing response in ...
Nevis Kathleen K Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, - - 2013
The mammalian outflow tract (OFT) and primitive right ventricle arise by accretion of newly differentiated cells to the arterial pole of the heart tube from multi-potent progenitor cells of the second heart field (SHF). While mounting evidence suggests that the genetic pathways regulating SHF development are highly conserved in zebrafish, ...
Du Xueyu X Department of Fibre and Polymer Technology, Royal Institute of Technology, Kungliga Tekniska Högskolan, Teknikringen 56-58, SE-10044, Stockholm, - - 2013
It is of both theoretical and practical importance to develop a universally applicable approach for the fractionation and sensitive lignin characterization of lignin-carbohydrate complexes (LCCs) from all types of lignocellulosic biomass, both natively and after various types of processing. In the present study, a previously reported fractionation approach that is ...
Abdulwahed Hussein Saad Rezk - - 2013
Bronchoscopy is an important diagnostic method for the tracheobronchial, thoracic, and mediastinal lesions. It is limited by the physical progression of the bronchoscope. This represents a problem when assessing difficult airways, such as a lumen narrowed from any cause. Bronchoscopy can be performed with flexible fiberoptic bronchoscopy (FOB), which remains ...
Mainardi Federico - - 2013
The headache attributed to airplane travel, also named "airplane headache", is characterized by the sudden onset of a severe head pain exclusively in relation to airplane flights, mainly during the landing phase. Secondary causes, such as upper respiratory tract infections or acute sinusitis, must be ruled out. Although its cause ...
Jolley Richard P - - 2013
The autistic impairments in emotional and social competence, imagination and generating ideas predict qualitative differences in expressive drawings by children with autism beyond that accounted by any general learning difficulties. In a sample of 60 5-19-year-olds, happy and sad drawings were requested from 15 participants with non-savant autism and compared ...
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