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Chen Nai-Ching - - 2013
While lesion patterns in white matter have been extensively reported in the literature on carbon monoxide (CO) intoxication, reports on the effects on gray matter damage are less common. The aim of this study was to investigate regional damage patterns focusing on gray matter using Tc ethyl cysteinate dimer (ECD) ...
Peterson T A - - 2013
Class I human leukocyte antigens (HLA) play an important role in the adaptive immune response by presenting antigens to CD8+ T cells. Studies have reported that several HLA class I alleles are associated with differential disease progression in human immunodeficiency virus (HIV)-infected individuals, however, few class I associations with resistance ...
Adeyemi Oluyemisi - - 2013
Pelvic osteomyelitis is a rare but serious condition that has the potential for systemic and muscular complications if left untreated. The diagnosis is difficult due to the relative rarity of the disease, the difficulty of localizing the site of the infection, and the tendency for the presentation to mimic other ...
Samama Meyer Michel - - 2013
No routine coagulation laboratory test is recommended during rivaroxaban or dabigatran treatment. However measuring drug concentration and/or anticoagulant activity can be desirable in some special clinical settings, such as bleeding, thrombosis recurrence or emergency surgery. The effects of dabigatran etexilate and rivaroxaban on various coagulation assays have been previously studied ...
Beach Thomas G TG Banner Sun Health Research Institute, Sun City, Arizona 85351, USA. - - 2013
The clinical diagnosis of Parkinson disease (PD) is incorrect in 30% or more of subjects particularly at the time of symptom onset. Because Lewy-type α-synucleinopathy is present in the submandibular glands of PD patients, we assessed the feasibility of submandibular gland biopsy for diagnosing PD. We performed immunohistochemical staining for ...
Koner Apurba L AL Department of Biochemistry, Oxford University, South Parks Road, OX1 3QU, United Kingdom. - - 2013
Fluorescent nanoparticles have enabled many discoveries regarding how molecular machines function. Quantum dots have been the dominant class of fluorescent nanoparticles but suffer from blinking and from a substantial dark fraction--particles where the fluorescence is never seen--complicating any analysis of biological function. Nanoparticles composed of conjugated fluorescent polymers (Pdots) have ...
Snider Erik J EJ Department of Chemistry, Dartmouth College, Hanover, NH 03755, - - 2013
Using a collection of dye-labeled cytochrome c (cyt c) variants, we identify transformations of the heterogeneous cardiolipin (CL)-bound cyt c ensemble with added ATP. Distributions of dye-to-heme distances P(r) from time-resolved fluorescence resonance energy transfer show that ATP decreases the population of largely unfolded cyt c conformers, but its effects ...
Bjelic Sinisa - - 2013
The Morita-Baylis-Hillman reaction forms a carbon-carbon bond between the α-carbon of a conjugated carbonyl compound and a carbon electrophile. The reaction mechanism involves Michael addition of a nucleophile catalyst at the carbonyl β-carbon, followed by bond formation with the electrophile and catalyst disassociation to release the product. We used Rosetta ...
Yang Dachi - - 2013
The image shows an artistic version of a Pd nanowire surrounded by hydrogen molecules. The nanowire is electrically connected to the Pt electrodes of a sensor device by L. F. Fonseca and co-workers to study the effects of reduced temperature on its electrical response during hydrogen gas exposure. The TEM ...
Guo Longhua - - 2013
The picture shows an approach to real-time monitoring of single molecular binding events by the construction of a reconfigurable colorimetric DNA switch, described on page 234. A significant spectral shift of over 60 nm is achievable from on-off switching. The switching is based on changing the interparticle distance between gold ...
Ravera Enrico E Department of Chemistry Ugo Schiff and Magnetic Resonance Center (CERM), University of Florence, 50019 Sesto Fiorentino (FI), - - 2013
Using the 480 kDa iron-storage protein complex, apoferritin (ApoF), as an example, we demonstrate that sizable dynamic nuclear polarization (DNP) enhancements can be obtained on sedimented protein samples. In sedimented solute DNP (SedDNP), the biradical polarizing agent is co-sedimented with the protein, but in the absence of a glass-forming agent. ...
Yang Bin - - 2013
The Schottky-junction structure has been broadly applied in inorganic photovoltaic devices but has not yet been successfully applied in organic photovoltaic devices. Jinsong Huang and co-workers report on page 572 fullerene-based Schottky-junction devices that can output a much larger open-circuit voltage (∼0.95 V) than most bulk heterojunction (BHJ) organic photovoltaic ...
Fuchs Yannick - - 2013
A new material combining a molecularly imprinted polymer for specific analyte recognition, and a holographic structure for optochemical sensing is described by Karsten Haupt, Olivier Soppera, and co-workers on page 566. The material is obtained in one step through photo-polymerization with interfering laser beams, resulting in a holographic molecularly imprinted ...
Ahantarig Arunee - - 2013
The symbiotic microorganisms of arthropod vectors are highly significant from several points of view, partly due to their possible roles in the transmission of pathogenic causative agents by blood-sucking vectors. Although ticks are well studied because of their significance to human health, novel microbial associations remain to be described. This ...
Csaba György - - 2013
The notion of the perinatal "hormonal imprinting" has been published at first in 1980 and since that time it spred expansively. The imprintig develops at the first encounter between the developing receptor and the target hormone - possibly by the alteration of the methylation pattern of DNA - and it ...
Shahin Saba - - 2013
The present experiment was designed to study the 2.45 GHz low-level microwave (MW) irradiation-induced stress response and its effect on implantation or pregnancy in female mice. Twelve-week-old mice were exposed to MW radiation (continuous wave for 2 h/day for 45 days, frequency 2.45 GHz, power density = 0.033549 mW/cm(2), and specific absorption rate = 0.023023 W/kg). At the end of ...
Boehm Laura B - - 2013
Traditionally, the new graduate registered nurse (RN) transition has included a didactic and skills-based orientation accompanied by a period of preceptored practice. However, these methods do not ensure that new RNs are in a state of reduced anxiety to fully interact with their new environment. Transition to practice may cause ...
Shen Xinqian - - 2013
A Tn5 transposition vector, pMOD-tet-egfp, was constructed and used for the random insertional mutagenesis of Bacillus pumilus. Various parameters were investigated to increase the transformation efficiency B. pumilus DX01 via Tn5 transposition complexes (transposome): bacterial growth phase, type of electroporation buffer, electric field strength, and recovery medium. Transformation efficiency was ...
Huang Jin - - 2013
The outgrowth of root hairs from the epidermal cell layer is regulated by a strict genetic regulatory system and external growth conditions. Rice plants cultivated in water-logged paddy land are exposed to a soil ecology that differs from the environment surrounding upland plants, such as Arabidopsis and maize. To identify ...
Ságodi László - - 2013
Polycystic ovary syndrome is a heterogeneous disorder characterized by chronic ovulatory dysfunction and hyperandrogenism. It occurs in 6-8% of the female population in the reproductive age. The syndrome may be associated with various metabolic disorders which may impair the quality of life and life expectancy of patients. The diagnosis in ...
Kabbage Maria - - 2013
The aim of this study was to evaluate calreticulin expression in infiltrating ductal breast carcinomas (IDCAs), as well as its relationships with clinicopathological parameters of the disease. Using a two-dimensional gel electrophoresis/matrix-assisted laser desorption ionization time of flight mass spectrometry investigation coupled to an immunohistochemical approach, we have assessed the ...
Johnson Eric O EO Behavioral Health Epidemiology Program, RTI International, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709-12194, USA. - - 2013
A great promise of publicly sharing genome-wide association data is the potential to create composite sets of controls. However, studies often use different genotyping arrays, and imputation to a common set of SNPs has shown substantial bias: a problem which has no broadly applicable solution. Based on the idea that ...
Devers Patricia L - - 2013
The 1997 discovery of free fetal DNA in maternal plasma launched clinical researchers' efforts to establish a reliable method for non-invasive prenatal testing for fetal genetic conditions. Various methods, including, but not limited to, massively parallel sequencing (MPS) and selective analysis of cell-free fetal DNA in maternal plasma, have recently ...
Komnenich Pauline - - 2013
The Nursing Education Exchange (NEXus) is a consortium of academic doctoral programs in nursing, initiated in response to a national shortage of well-qualified nurse educators and the need to increase the number of doctoral faculty in nursing programs across the United States. The vision for the consortium was to use ...
Uriarte G - - 2013
The aim of the study was to analyze the phenotypic and epigenetic changes induced by the shift to a chow diet after an obesogenic environment. Animals were randomized to fed chow (control group) or high-fat-sucrose diet (HFS). After 10 weeks, half of the rats fed with HFS diet were reassigned to ...
Anderko Laura - - 2013
Nurses and other health professionals are often asked about the benefits and risks of fish consumption. The combination of conflicting media messages about these risks and benefits and limited knowledge has led to confusion about how to properly advise people about safe fish consumption. "Fish Facts for Health Professionals" was ...
Wang Meimei - - 2013
Business Intelligence (BI) has caused extensive concerns and widespread use in gathering, processing and analyzing data and providing enterprise users the methodology to make decisions. Different from traditional BI architecture, this paper proposes a new BI architecture, Top-Down Scalable BI architecture with defining mechanism for enterprise decision making solutions and ...
Kappe Thomas - - 2013
PURPOSE: Subacromial decompression is the standard surgical treatment of subacromial impingement syndrome. Unsatisfactory results have been reported for concomitant lesions as well as inadequate diagnosis. We sought to determine the predictive value of the preoperative examination for the results of arthroscopic subacromial decompression in impingement syndrome. METHODS: Forty-nine shoulder joints ...
Smith Marianne M The University of Iowa College of Nursing, Iowa City, Iowa 52242, USA. - - 2013
Depression is a common, disabling, and underrecognized problem among older adults in assisted living (AL) settings. The purpose of this study was to evaluate stakeholder perceptions of using a blended model of depression care that combines essential features of evidence-based collaborative care and older adult outreach for use in AL ...
Kisfali Péter - - 2013
Larsen-syndrome is a rare genetic skeletal dysplasia belonging to the group of actin-binding filamin B associated diseases. The features include congenital dislocations of the large joints, scoliosis and cervical kyphosis, short, broad, spatulate distal phalanges, and distinctive craniofacies. Diagnosis is based on clinical and radiographic findings and confirmed by molecular ...
Towsley Gail L - - 2013
We examined the effect of market and organizational characteristics on nursing home quality as measured by deficiencies (number and weighted) on states in a rural region of the United States. Rural nursing homes in five Mountain West states (N = 161) were sampled from the Online Survey Certification and Reporting ...
Deng Xiaohong - - 2013
Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested as a marker of prognosis and response to treatment in breast cancer. In vitro, TIMP-1 can regulate shedding of the extracellular domain of HER2 and signalling via the Akt pathway, and we hypothesize that TIMP-1 therefore can affect sensitivity to the HER2-targeting ...
Rasineni Karuna - - 2013
High intake of dietary fructose has been shown to exert a number of adverse metabolic effects in humans and experimental animals. The present study was proposed to elucidate the effect of Catharanthus roseus (C. roseus) leaf powder treatment on alterations in carbohydrate and lipid metabolisms in rats fed with high-fructose ...
Lewenson Sandra B - - 2013
This article presents the use of a case story about a fictitious character, Professor Able, as a strategy to learn about the role of the nurse educator and to assist in the transition from clinical practice into that role. The story evolves over a 13-week semester in an engaging, asynchronous ...
Nordstrand Annika A Department of Radiation Sciences, Oncology, Umeå University, 901 85, Umeå, - - 2013
Prostate cancer (PC) bone metastases show weak responses to conventional therapies. Bone matrix is rich in growth factors, with insulin-like growth factor-1 (IGF-1) being one of the most abundant. IGF-1 acts as a survival factor for tumor cells and we speculate that bone-derived IGF-1 counteracts effects of therapies aimed to ...
Sári Eszter - - 2013
Hairy cell leukemia is a mature B-cell non-Hogkin lymphoma characterized by unique clinical, morphological and immunhistochemical features. Patients with hairy cell leukemia usually present with splenomegaly, progressive pancytopenia and a relative indolent clinical course. The diagnosis does not always indicate immediate treatment, as treatment depends on the clinical stage of ...
Tomcsányi János - - 2013
The authors report the spiked helmet ST-segment elevation in two patients in order to draw attention to this high-risk electrocardiographic sign. This form of ST-segment elevation needs an urgent evaluation and management of the critically ill patient. Orv. Hetil., 2013, 154, 147-149.
Roberts Darren M DM New South Wales Poisons Information Centre, Children's Hospital at Westmead, Sydney, NSW, Australia. - - 2013
To report the frequency and clinical outcomes of Amanita phalloides poisoning in the Australian Capital Territory and New South Wales, and the treatments used (including silibinin). Retrospective case series of patients admitted to public hospitals in Canberra and Sydney for suspected A. phalloides poisoning between 1999 and 2012 (identified from ...
Li Yu-qiong YQ Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, - - 2013
To investigate whether apocynin, a NADPH oxidase inhibitor, produced cardioproteictive effects in Ang II-induced hypertensive mice, and to elucidate the underlying mechanisms. C57BL/6 mice were subcutaneously infused Ang II for 4 weeks to mimic cardiac remodeling and fibrosis. Concomitantly the mice were administered apocynin (100 mg·kg(-1)·d(-1)) or/and the aldosterone receptor ...
Croft Michael M Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA. - - 2013
Inhibitors of tumour necrosis factor (TNF) are among the most successful protein-based drugs (biologics) and have proven to be clinically efficacious at reducing inflammation associated with several autoimmune diseases. As a result, attention is focusing on the therapeutic potential of additional members of the TNF superfamily of structurally related cytokines. ...
Mascarenhas John - - 2013
Panobinostat (LBH589), a novel histone deacetylase inhibitor (HDACi), was evaluated in a phase I study of patients with primary myelofibrosis (PMF) and post-essential thrombocythaemia/polycythaemia vera-related myelofibrosis (Post-ET/PV MF). Eighteen patients (PMF 56%; Post-PV MF 28%; Post-ET MF 17%) were treated in three cohorts at oral doses of (i) 20, (ii) ...
Watanabe K K Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, - - 2014
Little is known about chromatin mechanisms that regulate tumor-initiating cells that are proposed to be responsible for tumor recurrence and relapse. We have previously shown that Pygopus 2 (Pygo2), a chromatin effector and context-dependent Wnt signaling coactivator, regulates mammary gland development by expanding epithelial stem/progenitor cells. However, the role of ...
Li Jing J Department of Burns and Plastic Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi-an 710038, - - 2013
To examine the changes in electrolyte concentrations after addition of zeolite-based hemostat QuikClot in blood and the effects of zeolite on blood coagulation in vitro. Fresh blood was taken from healthy adult volunteers and sheep, and the electrolyte concentrations in blood were measured using a blood electrolyte analyzer. Zeolite Saline ...
Shinopoulos Katherine E - - 2013
Secondary electron transfer in photosystem II (PSII), which occurs when water oxidation is inhibited, involves redox-active carotenoids (Car), as well as chlorophylls (Chl), and cytochrome b (559) (Cyt b (559)), and is believed to play a role in photoprotection. Car(D2) may be the initial point of secondary electron transfer because ...
Li Qian Q Department of Epidemiology, Harvard School of Public Health, Boston, MA, - - 2013
To validate an algorithm that uses delivery date and diagnosis codes to define gestational age at birth in electronic health plan databases. Using data from 225,384 live born deliveries to women aged 15-45 years in 2001-2007 within eight of the 11 health plans participating in the Medication Exposure in Pregnancy Risk ...
Lindström Ann-Charlotte - - 2013
Abstract Aim: The aim of this study was to describe occupational therapists' experiences of rehabilitation of patients with limited awareness after stroke. Methods: To capture occupational therapists' experiences, a qualitative approach was chosen using five focus groups consisting of 22 participants engaged in group discussions with open-ended questions based on ...
Litwin A S - - 2013
BACKGROUND: Lacrimal sac fistulae can arise after an episode of dacryocystitis, usually forming below the medial canthus. Preceding symptoms of a watery eye with mucous discharge and a history or signs of inflammation are typical. OBJECTIVES: To highlight the features of lacrimal sac fistulae and encourage readers to consider this ...
Keijsers R R M C - - 2013
BACKGROUND: In the pathogenesis of psoriasis, pro-inflammatory T-cells are strongly involved in the inflammatory process, where regulatory T-cell (Treg) function is impaired. OBJECTIVES: As effective Treg function is associated with a numerical balance between Treg and effector T-cells, we wondered whether Treg/T-helper cell ratios may be associated with certain stages ...
Lubeck Paula - - 2013
Nursing education programs are charged with the task of transforming the way future nurses are educated to better meet the demands of an ever-changing health care system. The tradition of lecture-based theory courses and on-site clinical experiences is slowly being replaced by evidence-based teaching formats that focus on actively engaging ...
Madaiah Malavalli - - 2013
New 3-[(2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl)methyl]benzonitrile derivatives 8-37 were synthesized and their pharmacological activities were determined with the objective to better understand their structure-activity relationship (SAR) for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) and pentylenetetrazole (PTZ) test. Compounds 11, 18, 31, and 32 ...
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