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Results 301 - 350 of 4798
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Towsley Gail L - - 2013
We examined the effect of market and organizational characteristics on nursing home quality as measured by deficiencies (number and weighted) on states in a rural region of the United States. Rural nursing homes in five Mountain West states (N = 161) were sampled from the Online Survey Certification and Reporting ...
Deng Xiaohong - - 2013
Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested as a marker of prognosis and response to treatment in breast cancer. In vitro, TIMP-1 can regulate shedding of the extracellular domain of HER2 and signalling via the Akt pathway, and we hypothesize that TIMP-1 therefore can affect sensitivity to the HER2-targeting ...
Kappe Thomas - - 2013
PURPOSE: Subacromial decompression is the standard surgical treatment of subacromial impingement syndrome. Unsatisfactory results have been reported for concomitant lesions as well as inadequate diagnosis. We sought to determine the predictive value of the preoperative examination for the results of arthroscopic subacromial decompression in impingement syndrome. METHODS: Forty-nine shoulder joints ...
Smith Marianne - - 2013
Depression is a common, disabling, and underrecognized problem among older adults in assisted living (AL) settings. The purpose of this study was to evaluate stakeholder perceptions of using a blended model of depression care that combines essential features of evidence-based collaborative care and older adult outreach for use in AL ...
Nordstrand Annika A Department of Radiation Sciences, Oncology, Umeå University, 901 85, Umeå, - - 2013
Prostate cancer (PC) bone metastases show weak responses to conventional therapies. Bone matrix is rich in growth factors, with insulin-like growth factor-1 (IGF-1) being one of the most abundant. IGF-1 acts as a survival factor for tumor cells and we speculate that bone-derived IGF-1 counteracts effects of therapies aimed to ...
Shiroff Adam M - - 2013
Introduction Tissue transplantation is an important adjunct to modern medical care and is used daily to save or improve patient lives. Tissue allografts include bone, tendon, corneas, heart valves and others. Increasing utilization may lead to tissue shortages, and tissue procurement organizations continue to explore ways to expand the cadaveric ...
Grover Manita - - 2013
PURPOSE: The aim of this study was to assess the use of single implant-supported, magnet-retained mandibular overdentures to improve the oral health-related quality of life (OHRQoL) and masticatory performance of patients wearing conventional complete dentures. The study also aimed at comparing the OHRQoL, masticatory performance, and crestal bone loss with ...
Masumo Ray - - 2013
Abstract Objective. To assess the reproducibility of caregivers' responses to dietary recall from birth and 24-h dietary recall with respect to infants' intake of sugared snacks and to assess whether those assessment methods provide comparable results for groups of infants. Re-test reliability and clinical covariates of time to first exposure ...
Pozotrigo M - - 2013
Thalidomide, lenalidomide and bortezomib have increasingly been incorporated in first-line induction therapies for multiple myeloma. Concerns regarding the impact of these agents, especially lenalidomide, on stem cell mobilization prompted us to re-evaluate the risk factors that impact mobilization, including exposure to novel induction regimens. Among 317 patients who proceeded to ...
Chatenoud Liliane - - 2013
Although therapeutic advancements have made Hodgkin lymphoma (HL) a largely curable disease, trends in HL mortality have been variable across countries. To provide updated information on HL mortality in the Americas, overall and 20 to 44 years age-standardized (world population) mortality rates from HL were derived for the 12 Latin ...
Fu Na - - 2013
To optimize cellular delivery and specific labeling of tagged cytosolic proteins by biarsenical fluorescent probes built around a cyanine dye (Cy3) scaffold, we have systematically varied the polarity of the N-alkyl chain (i.e., 4-5 methylene groups appended by a sulfonate or methoxy ester moiety) and arsenic capping reagent (ethanedithiol versus ...
Eisenberg Michael L - - 2013
Anogenital distance (AGD) is used to define degree of virilization of genital development, with shorter length being associated with feminization and male infertility. The first exon of the androgen receptor (AR) consists of a polymorphic sequence of cytosine-adenine-guanine (CAG) repeats, with longer CAG repeat lengths being associated with decreased receptor ...
Martínez-González José María - - 2013
Abstract Objective. The aim of this study was to evaluate the satisfaction of rehabilitated edentulous patients in relation to implant prosthetic type. Materials and methods. This prospective cohort study included 40 completely edentulous patients wearing conventional prostheses. They were divided into two study groups: Group A contained 20 patients rehabilitated ...
Vandenbon Alexis - - 2013
ABSTRACT: BACKGROUND: Identification of cis- and trans-acting factors regulating gene expression remains an important problem in biology. Bioinformatics analyses of regulatory regions are hampered by several difficulties. One is that binding sites for regulatory proteins are often not significantly over-represented in the set of DNA sequences of interest, because of ...
Chan E W - - 2013
Lorcaserin is a new anti-obesity drug recently approved by US Food and Drug Administration. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the association of lorcaserin therapy with weight loss and adverse events in obese adults (18-65 years old). Weight loss of 3.23 kg (95% ...
Bertino Pietro - - 2013
Survivin protein is an attractive candidate for cancer immunotherapy since it is abundantly expressed in most common human cancers and mostly absent in normal adult tissues. Malignant mesothelioma (MM) is a deadly cancer associated with asbestos or erionite exposure for which no successful therapies are currently available. In this study, ...
Kalman Jonathan M - - 2013
Atrial fibrillation (AF) is estimated to affect 1%-2% of the population. It is increasing in prevalence and is associated with excess mortality, considerable morbidity and hospitalisations. AF is responsible for a significant and growing societal financial burden. Catheter ablation is an increasingly used therapeutic strategy for the management of AF; ...
Frank S A - - 2013
Three steps aid in the analysis of selection. First, describe phenotypes by their component causes. Components include genes, maternal effects, symbionts and any other predictors of phenotype that are of interest. Second, describe fitness by its component causes, such as an individual's phenotype, its neighbours' phenotypes, resource availability and so ...
Pearn John H - - 2013
Botanical taxonomy is a repository of medical biographical information. Such botanical memorials include the names of some indigenous orchids of Australia. By searching reference texts and journals relating to Australian botany and Australian orchidology, as well as Australian and international medical and botanical biographical texts, I identified 30 orchids indigenous to ...
Ma Hai-Rong - - 2013
Aim:Chickpea (Cicer arietinum L) is a traditional Uighur herb. In this study we investigated the estrogenic activities of the isoflavones extracted from chickpea sprouts (ICS) in ovariectomized rats.Methods:Ten-week-old virgin Sprague-Dawley female rats were ovariectomized (OVX). The rats were administered via intragastric gavage 3 different doses of ICS (20, 50 or ...
Sjöwall Christopher - - 2013
The pattern recognition molecules C-reactive protein (CRP) and C1q are of big interest in relation to the pathogenesis of systemic lupus erythematosus (SLE). Circulating autoantibodies against CRP and C1q are frequently found in SLE patients with active disease, particularly in lupus nephritis (LN), and rising levels reportedly relate to disease ...
Jiang Li - - 2013
Osteoarthritis (OA) is the most common form of arthritis, in which cartilage is irreversibly degraded, causing severe pain and disability. Current therapeutic strategies cannot repair damaged cartilage. We evaluated the repair potential of selected chondrogenic clonal MSCs (sC-MSCs) by delivering them into the injured cartilage site in a collagenase-induced OA ...
Liu Jun - - 2013
This study was performed to qualify goat fetal fibroblast (GFF) cell lines for genetic modification and somatic cell nuclear transfer (SCNT) to produce human lysozyme (hLYZ) transgenic goats. Nine GFF cell lines were established from different fetuses, and the proliferative lifespan and chromosomal stability were analyzed. The results suggested that ...
Heskamp Sandra - - 2013
Bevacizumab (anti-VEGF) and cetuximab (anti-EGFR) are approved antibodies for treatment of cancer. However, in advanced colorectal cancer, the combination fails to improve survival. As the reason for the lack of activity is unknown, this study aims to determine the effect of bevacizumab on targeting of anti-EGFR and IGF-1R antibodies in ...
Quail D F - - 2013
The progression of cancer from localized to invasive disease is requisite for metastasis, and is often characterized by epithelial-to-mesenchymal transition (EMT) and alterations in cellular adhesion and migration. Studies have shown that this transition is associated with an upregulation of embryonic stem cell-associated genes, resulting in a dedifferentiated phenotype and ...
Polato Nicholas R - - 2013
Coral populations have declined worldwide largely due to increased sea surface temperatures. Recovery of coral populations depends in part upon larval recruitment. Many corals reproduce during the warmest time of year when further increases in temperature can lead to low fertilization rates of eggs and high larval mortality. Microarray experiments ...
Eckert Kerena A - - 2013
OBJECTIVE: The aim of this study was to examine changes in the prevalence of use of prescribed medicines in Australian community samples. STUDY DESIGN AND SETTING: In this study, face-to-face interviews were carried out with random, representative samples of South Australian adults, aged ≥15 years. Data on self-reported use of prescribed ...
Ogoh Shigehiko - - 2013
The respiratory chemoreflex is known to be modified during orthostatic stress though the underlying mechanisms remain to be established. To detremine the potential role of cerebral hypoperfusion, we examined the relationship between changes in middle cerebral artery mean blood velocity (MCA Vmean) and pulmonary ventilation (VE) from supine control to ...
Li Shuyi - - 2013
Litchi chinensis pericarp from litchi processing waste is an important plant source of A-type procyanidins, which were considered as a natural dietary supplement due to its high biological activity in vivo reported. Litchi pericarp oligomeric procyanidins (LPOPC) didn't selectively modify the growth of Streptococcus thermophilus and Lactobacillus casei-01 at concentrations ...
Adams Michael J - - 2013
Objective: To better understand help-seeking behaviours and reproductive health disorders among Aboriginal and Torres Strait Islander men.Design, setting and participants: A cross-sectional mixed-methods study conducted from 1 May 2004 to 30 April 2005 of 293 Aboriginal and Torres Strait Islander men aged 18 2013s and over from urban, rural and remote communities in the Northern Territory ...
Devalankar Dattatray A - - 2013
The HKR of racemic anti- or syn-3-substituted epoxy esters catalyzed by a Co(iii)salen complex provides ready access to the corresponding enantioenriched 3,4-disubstituted γ-butyrolactones and 3-substituted epoxy esters. This strategy has been successfully employed in the formal synthesis of biologically active 3,4-disubstituted piperidine derivatives, (-)-paroxetine and Ro 67-8867 and a natural ...
Heathfield Emily - - 2013
OBJECTIVE: The study aims to assess whether the increasing use of cardiovascular magnetic resonance imaging in place of diagnostic cardiac catheterization in the management of pediatric patients with congenital heart disease has had an impact on pediatric cardiac care. DESIGN: Retrospective analysis of data was used. SETTING: The study was ...
Di Nicola Valerio - - 2013
This study presents a method for treating and structurally improving articulations affected by degenerative joint disease (DJD). The focus of this analysis is on two groups of patients: the first comprised patients over eighty years old, and the second comprised patients aged 45 to 55 years. The first group was ...
Preissler Natalie - - 2013
Electrokinetic charging of aqueous microjets was characterized by measuring streaming currents as a function of sodium iodide salt concentration. Measured streaming currents at high salt concentrations (up to 0.5 M) varied non-monotonically with the jet velocity and can be explained by a multipolar charge distribution at the nozzle-water interface. In ...
Triponez Yann - - 2013
The European genus Ophrys (Orchidaceae) is famous for its insect-like floral morphology, an adaptation for a pseudocopulatory pollination strategy involving Hymenoptera males. A large number of endemic Ophrys species have recently been described, especially within the Mediterranean Basin, which is one of the major species diversity hotspots. Subtle morphological variation ...
Li Qian - - 2013
PURPOSE: To validate an algorithm that uses delivery date and diagnosis codes to define gestational age at birth in electronic health plan databases. METHODS: Using data from 225 384 live born deliveries to women aged 15-45 years in 2001-2007 within eight of the 11 health plans participating in the Medication Exposure in ...
Lindström Ann-Charlotte - - 2013
Abstract Aim: The aim of this study was to describe occupational therapists' experiences of rehabilitation of patients with limited awareness after stroke. Methods: To capture occupational therapists' experiences, a qualitative approach was chosen using five focus groups consisting of 22 participants engaged in group discussions with open-ended questions based on ...
Litwin A S - - 2013
BACKGROUND: Lacrimal sac fistulae can arise after an episode of dacryocystitis, usually forming below the medial canthus. Preceding symptoms of a watery eye with mucous discharge and a history or signs of inflammation are typical. OBJECTIVES: To highlight the features of lacrimal sac fistulae and encourage readers to consider this ...
Keijsers R R M C - - 2013
BACKGROUND: In the pathogenesis of psoriasis, pro-inflammatory T-cells are strongly involved in the inflammatory process, where regulatory T-cell (Treg) function is impaired. OBJECTIVES: As effective Treg function is associated with a numerical balance between Treg and effector T-cells, we wondered whether Treg/T-helper cell ratios may be associated with certain stages ...
Lubeck Paula - - 2013
Nursing education programs are charged with the task of transforming the way future nurses are educated to better meet the demands of an ever-changing health care system. The tradition of lecture-based theory courses and on-site clinical experiences is slowly being replaced by evidence-based teaching formats that focus on actively engaging ...
Liu Wei - - 2013
Nanoparticles (NPs) entering a biological fluid undergo surface modification due to dynamic, physicochemical interactions with biological components, especially proteins. In this work we used complementary bio-physico-chemical approaches to characterize the effects of interactions between CeO(2) NPs, immunoglobulins (IgGs) and bovine serum albumin (BSA) of a similar size on protein structural ...
Chester Julia A - - 2013
Blunted cortisol responses to stress or trauma have been linked with genetic (familial) risk for both alcoholism and post-traumatic stress disorder (PTSD). Mouse lines selectively bred for high (HAP) or low (LAP) alcohol preference may be a relevant model of genetic risk for co-morbid alcoholism and PTSD in humans. HAP ...
Mukherjee Shomen - - 2013
How foragers balance risks during foraging is a central focus of optimal foraging studies. While diverse theoretical and empirical work has revealed how foragers should and do manage food and safety from predators, little attention has been given to the risks posed by dangerous prey. This is a potentially important ...
Tayfur Ozge - - 2013
Abstract Emotional exhaustion, argued to be burnout's core dimension, can manifest itself as decreased productivity and job dissatisfaction. This study aims to determine how lack of reciprocity, lack of supervisory support, high workload, and work-family conflict affect emotional exhaustion. Data were collected from 295 physicians working at private and public ...
Watanabe K - - 2013
Little is known about chromatin mechanisms that regulate tumor-initiating cells that are proposed to be responsible for tumor recurrence and relapse. We have previously shown that Pygopus 2 (Pygo2), a chromatin effector and context-dependent Wnt signaling coactivator, regulates mammary gland development by expanding epithelial stem/progenitor cells. However, the role of ...
Li Jing - - 2013
Aim:To examine the changes in electrolyte concentrations after addition of zeolite-based hemostat QuikClot in blood and the effects of zeolite on blood coagulation in vitro.Methods:Fresh blood was taken from healthy adult volunteers and sheep, and the electrolyte concentrations in blood were measured using a blood electrolyte analyzer. Zeolite Saline Solution ...
Laurent Heidemarie K - - 2013
Depressed mothers show negatively biased responses to their infants' emotional bids, perhaps due to faulty processing of infant cues. This study is the first to examine depression-related differences in mothers' neural response to their own infant's emotion faces, considering both effects of perinatal depression history and current depressive symptoms. Primiparous ...
Shiu K-K - - 2013
Overexpression of the receptor tyrosine kinase ERBB2 (also known as HER2) occurs in around 15% of breast cancers and is driven by amplification of the ERBB2 gene. ERBB2 amplification is a marker of poor prognosis, and although anti-ERBB2-targeted therapies have shown significant clinical benefit, de novo and acquired resistance remains ...
Galluzzi L - - 2013
Pyridoxal-5'-phosphate (PLP), the bioactive form of vitamin B6, reportedly functions as a prosthetic group for >4% of classified enzymatic activities of the cell. It is therefore not surprising that alterations of vitamin B6 metabolism have been associated with multiple human diseases. As a striking example, mutations in the gene coding ...
Huang Xiong-Gao - - 2013
The vitreous has been shown to induce epithelial-mesenchymal transdifferentiation (EMT) because it induces fibroblast-like morphology, enhanced migration and invasion in retinal pigment epithelial (RPE) cells in proliferative vitreoretinopathy (PVR). Rac1 is the principal mediator of cell migration. In the current study, the relationship between Rac1 and cell migration and invasion ...
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