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- - 2013
This policy was developed by a joint writing panel of the American College of Emergency Physicians and the American Academy of Neurology. The panel reviewed the literature to derive evidence-based recommendations to help clinicians answer the following critical questions: (1) Is intravenous tissue plasminogen activator (tPA) safe and effective for ...
Gosalbes M J - - 2013
Culture-dependent methods have shown that meconium, the newborn's first intestinal discharge, is not sterile, but the diversity of bacteria present in this material needs to be further characterized by means of more sensitive molecular techniques. Our aims were to characterize molecularly the meconium microbiota in term infants, to assess whether ...
Georgopoulos Sotirios D - - 2013
Treatment of Helicobacter pylori (H. pylori) infection is crucial for prevalent disease's management, including gastritis, peptic ulcer and gastric cancer, whereas novel extradigestive causal associations are increasingly being recognized. Despite long-standing efforts, there is not as yet an optimal empirical therapy to eradicate H. pylori. In the present article the ...
Bozek A - - 2013
Immunotherapy in elderly patients is controversial, and there is still no evidence supporting this treatment's safety and efficacy in this population. This study was performed to evaluate the safety and efficacy of specific sublingual immunotherapy for house dust mite (HDM) allergens in patients over 60 years of age with allergic rhinitis ...
Koeppen Arnulf H - - 2013
Friedreich ataxia is an autosomal recessive disorder that affects children and young adults. The mutation consists of a homozygous guanine-adenine-adenine trinucleotide repeat expansion that causes deficiency of frataxin, a small nuclear genome-encoded mitochondrial protein. Low frataxin levels lead to insufficient biosynthesis of iron-sulfur clusters that are required for mitochondrial electron ...
Runge-Morris Melissa M Institute of Environmental Health Sciences, Wayne State University, Detroit, Michigan 48201, USA. - - 2013
The cytosolic sulfotransferases (SULTs) are a multigene family of enzymes that catalyze the transfer of a sulfonate group from the physiologic sulfate donor, 3'-phosphoadenosine-5'-phosphosulfate, to a nucleophilic substrate to generate a polar product that is more amenable to elimination from the body. As catalysts of both xenobiotic and endogenous metabolism, ...
van Rooij Linda G M LG Department of Neonatology, KE 04.123.1, Wilhelmina Children's Hospital, University Medical Centre Utrecht, PO Box 85090, 3508 AB, Utrecht, The Netherlands. - - 2013
Neonatal seizures can be classified as tonic, clonic, myoclonic, and subtle. A clinical diagnosis is not easy as seizures are usually subtle in neonates. In the majority of newborn infants seizures are subclinical. On the other hand, not all abnormal movements identified by clinicians as clinical seizures are accompanied by ...
Smolders Joost J Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands. - - 2013
Vitamin D deficiency has been implicated as a risk factor for multiple sclerosis (MS), but how vitamin D metabolism affects MS pathophysiology is not understood. We studied the expression of vitamin D receptor (VDR) and related enzymes, including 1,25(OH)(2)D-24-hydroxylase (24-OHase; CYP24A1) and 25(OH)D-1α-hydroxylase (CYP27B1), in CNS tissues of 39 MS ...
Dong Aisheng A Department of Nuclear Medicine, Changhai Hospital, Shanghai, - - 2013
A 21-year-old woman was admitted to our hospital after incidental detection of a left renal lesion on ultrasound scan. Abdominal contrast-enhanced CT scan revealed a moderately enhanced lesion in the left kidney and a round mass with slight enhancement in the retroperitoneum. FDG PET/CT imaging was performed for whole-body survey, ...
Ahmed Ali A University of Alabama at Birmingham, Birmingham, AL, USA. - - 2013
The role of renin-angiotensin inhibition in older patients with diastolic heart failure and chronic kidney disease remains unclear. Of the 1340 patients (age ≥65 years) with diastolic heart failure (ejection fraction ≥45%) and chronic kidney disease (estimated glomerular filtration rate <60 mL/min/1.73 m(2)), 717 received angiotensin-converting enzyme inhibitors or angiotensin ...
Goldberg Robert J RJ Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA 01655, USA. - - 2013
In this article we provide an overview of the different study designs commonly utilized in carrying out clinical and public health research and of the points to consider in reviewing these study designs. The design and conduct of cross-sectional health surveys, case-control, prospective, and case-crossover observational studies, and randomized controlled ...
Yang Bao-Zhu BZ Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, - - 2013
Child abuse is highly prevalent and associated with increased risk for a range of health problems, including cancer, cardiovascular disease, diabetes, psychiatric disorders, and other health problems. Little is currently known about the mechanism by which early adversity confers risk for health problems later in life. To determine if there ...
Wei Feifei F Department of Biostatistics, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, USA. - - 2013
Little information is available on geographic disparity of human papillomavirus (HPV) vaccination among women aged 18-26 years in the U.S. Genital HPV is the most common sexually transmitted infection in the U.S. Persistent HPV infection with oncogenic types can cause cervical cancer. This study utilized data collected from the 2010 ...
Mu Liancai L Upper Airway Research Laboratory, Department of Research, Hackensack University Medical Center, New Jersey 07601, USA. - - 2013
Parkinson disease (PD) is a neurodegenerative disease primarily characterized by cardinal motor manifestations and CNS pathology. Current drug therapies can often stabilize these cardinal motor symptoms, and attention has shifted to the other motor and nonmotor symptoms of PD that are resistant to drug therapy. Dysphagia in PD is perhaps ...
Adams Monica L ML Center for Evaluation & Sociomedical Research, Graduate School of Public Health, University of Puerto Rico, PO BOX 365067, San Juan, PR 00936-5067. - - 2013
School smoking bans give officials the authority to provide a smoke-free environment, but enacting policies within the school walls is just one step in comprehensive tobacco prevention among students. It is necessary to investigate factors beyond the school campus and into the neighborhoods that surround schools. The purpose of this ...
Yuan Shuanghu Tiger ST Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, P.R. - - 2013
We hypothesized that radiation-induced thoracic toxicity (RITT) of the lung, esophagus and pericardium share a similar mechanism, and aimed to examine whether genetic variation of transforming growth factor-beta1 (TGFβ1), tissue plasminogen activator (tPA) and angiotensin converting enzyme (ACE), are associated with RITT in patients with non-small-cell lung cancer (NSCLC). Patients ...
Jack Clifford R CR Jr Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA. - - 2013
In 2010, we put forward a hypothetical model of the major biomarkers of Alzheimer's disease (AD). The model was received with interest because we described the temporal evolution of AD biomarkers in relation to each other and to the onset and progression of clinical symptoms. Since then, evidence has accumulated ...
Elsner Ann E AE Indiana University School of Optometry, Bloomington, Indiana 47405, USA. - - 2013
To develop a simplified device that performs fundus perimetry techniques such as fixation mapping and kinetic perimetry. We added visual stimulation to a near-infrared retinal imager, the laser scanning digital camera (LSDC). This device uses slit scanning illumination combined with a two-dimensional CMOS (complementary metal oxide semiconductor) detector, with continuous ...
Wilcox Sara S Department of Exercise Science, University of South Carolina, Columbia, 29208, USA. - - 2013
Faith-based interventions hold promise for promoting health in ethnic minority populations. To date, however, few of these interventions have used a community-based participatory research (CBPR) approach, have targeted both physical activity and healthy eating, and have focused on structural changes in the church. To report the results of a group ...
Slater Sandy J SJ Institute for Health Research and Policy, Chicago, Illinois, USA. - - 2013
Neighborhood design features have been associated with health outcomes, including the prevalence of obesity. This study examined the association between walkability and adolescent weight in a national sample of public secondary school students and the communities in which they live. Data were collected through student surveys and community observations between ...
Stoltz D J DJ University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, - - 2013
Specific patterns of allergic sensitization as well as quantification of the in vitro IgE response in early life may provide relevant clinical insight into future rhinitis and asthma risk. To define relationships among established sensitization to particular aeroallergens, quantitative analyses of allergen-specific IgE levels, pet exposure and sensitization, and asthma ...
Li Tiangang T Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272, - - 2013
Bile acids are signaling molecules that activate nuclear receptors, such as farnesoid X receptor, pregnane X receptor, constitutive androstane receptor, and vitamin D receptor, and play a critical role in the regulation of lipid, glucose, energy, and drug metabolism. These xenobiotic/endobiotic-sensing nuclear receptors regulate phase I oxidation, phase II conjugation, ...
Cascalho Marilia I MI Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. - - 2013
Scarcely anyone would dispute that donor-specific B cells and the Abs that they produce can cause rejection of transplants. Less clear and more controversial, however, is the possibility that donor-specific B cells and the Abs that they produce are one or more means by which transplants can be protected from ...
McDonald Caleb B CB Department of Biochemistry and Molecular Biology, Leonard Miller School of Medicine, University of Miami, Miami, FL 33136, - - 2013
Allostery plays a key role in dictating the stoichiometry and thermodynamics of multi-protein complexes driving a plethora of cellular processes central to health and disease. Herein, using various biophysical tools, we demonstrate that although Sos1 nucleotide exchange factor and Gab1 docking protein recognize two non-overlapping sites within the Grb2 adaptor, ...
Stroebele Nanette N University of Colorado Anschutz Medical Campus, Mailstop C263, 13001 E 17th Place, Aurora, CO 80045, USA. - - 2013
To improve support and justification for health promotion efforts in schools, it is helpful to understand how students' health behaviors affect academic performance. Fifth-grade students completed an online school-administered health survey with questions regarding their eating behavior, physical activity, academic performance, and sleep patterns. Differences in health behaviors were examined ...
Huynh Jimmy L JL Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, - - 2013
Clinical neurologists and scientists who study multiple sclerosis face open questions regarding the integration of epidemiological data with genome-wide association studies and clinical management of patients. It is becoming evident that the interplay of environmental influences and individual genetic susceptibility modulates disease presentation and therapeutic responsiveness. The molecular mechanisms through ...
Wen Ming M Department of Sociology, University of Utah, Lake City, UT 84112, USA. - - 2013
Little national evidence is available on spatial disparities in distributions of parks and green spaces in the USA. This study examines ecological associations of spatial access to parks and green spaces with percentages of black, Hispanic, and low-income residents across the urban-rural continuum in the conterminous USA. Census tract-level park ...
Hager Erin R ER Department of Pediatrics, Growth and Nutrition Division, University of Maryland School of Medicine, 737 West Lombard Street, Baltimore, MD 21201, USA. - - 2013
Neighborhood perceived/built environment and physical activity (PA) associations have been examined for adolescents around homes, but not surrounding schools. The purpose of this paper is to examine if positive perceptions/built environment in neighborhoods surrounding schools predict PA among low-income, urban adolescent girls. Measures include: minutes in moderate-vigorous PA (MVPA, ankle ...
Gerber Yariv Y Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, - - 2013
There is growing awareness of an association between cardiovascular disease and fractures, and a temporal increase in fracture risk after myocardial infarction has been identified. To further explore the nature of this relationship, we systematically examined the association of hip fracture with all disease categories and assessed related secular trends. ...
Slining Meghan M MM Department of Nutrition, University of North Carolina at Chapel Hill, - - 2013
Heretofore, corporate voluntary pledges to improve the health of Americans have been linked neither to explicit measurable commitments nor to a framework for an independent evaluation. The Healthy Weight Commitment Foundation (HWCF), whose members include 16 of the nation's leading consumer packaged goods food and beverage manufacturers, voluntarily pledged to ...
Khoo C C H CC Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO 80523, - - 2013
RNA interference (RNAi) is the major innate antiviral pathway in Aedes aegypti that responds to replicating arboviruses such as dengue virus (DENV) and Sindbis virus (SINV). On the one hand, the mosquito's RNAi machinery is capable of completely eliminating DENV2 from Ae. aegypti. On the other, transient silencing of key genes ...
Jiang Mengxi M Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, - - 2013
The constitutive androstane receptor (CAR, NR1I3) is a member of the nuclear receptor superfamily. Initially recognized as a xenobiotic receptor, CAR has been increasingly appreciated for its endobiotic functions in influencing glucose and lipid metabolism, whose dysregulations are implicated in the most prevalent metabolic disorders, such as obesity and type ...
Lax Nichola Z NZ Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, The Medical School, Newcastle University, Newcastle upon Tyne, - - 2013
Mitochondrial respiratory chain disease is associated with a spectrum of clinical presentations and considerable genetic heterogeneity. Here we report molecular genetic and neuropathologic findings from an adult with an unusual manifestation of mitochondrial DNA disease. Clinical features included early-onset cataracts, ataxia, and progressive paraparesis, with sequencing revealing the presence of ...
Gavala M L ML Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792-9988, - - 2013
Allergic airway inflammation contributes to the airway remodelling that has been linked to increased obstruction and morbidity in asthma. However, the mechanisms by which allergens contribute to airway remodelling in humans are not fully established. CCL18, chitotriosidase (CHIT1) and YKL-40 are readily detectable in the lungs and contribute to remodelling ...
Pulsford Richard M RM Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Devon, United Kingdom. - - 2013
Prospective studies report associations between indicators of time spent sitting and obesity risk. Most studies use a single indicator of sedentary behavior and are unable to clearly identify whether sedentary behavior is a cause or a consequence of obesity. To investigate cross-sectional and prospective associations between multiple sitting time indicators ...
Mani Sridhar S Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA. - - 2013
Adopted orphan nuclear receptor (NR), pregnane X receptor (PXR), plays a central role in the regulation of xeno- and endobiotic metabolism. Since the discovery of the functional role of PXR in 1998, there is evolving evidence for the role of PXR agonists in abrogating metabolic pathophysiology (e.g., cholestasis, hypercholesterolemia, and ...
Harolds Jay J Division of Radiology and Biomedical Imaging, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA. - - 2013
There are 2 major classes of feedback. One class of feedback consists of the informal, numerous conversations between various people in the organization regarding the performance, behavior, and goals of an individual. Another class of feedback consists of formal reviews held once or twice a year between a supervisor and ...
Beach Thomas G TG Banner Sun Health Research Institute, Sun City, Arizona 85351, USA. - - 2013
The clinical diagnosis of Parkinson disease (PD) is incorrect in 30% or more of subjects particularly at the time of symptom onset. Because Lewy-type α-synucleinopathy is present in the submandibular glands of PD patients, we assessed the feasibility of submandibular gland biopsy for diagnosing PD. We performed immunohistochemical staining for ...
Dodson John A JA Section of Cardiology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, - - 2013
Despite the fact that 80% of patients with heart failure are aged more than 65 years, recognition of cognitive impairment by physicians in this population has received relatively little attention. The current study evaluated physician documentation (as a measure of recognition) of cognitive impairment at the time of discharge in ...
Baker Susan P SP Department of Health Policy and Management, Johns Hopkins University, Baltimore, Maryland, - - 2013
Recently, suicide exceeded motor vehicle crashes as the leading cause of injury death in the U.S. However, details of this change in suicide methods and the relationship to individual demographics, such as age and societal influences, have not been reported. To determine the characteristics of the changes in suicide rates ...
Reis Rodrigo S RS School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil. - - 2013
Physical inactivity plays a role in the acquisition of heart disease, type 2 diabetes, and breast and colon cancer. The impact of such noncommunicable diseases on low- and middle-income countries is a major global health concern, but most studies in this area have focused on high-income countries. A better understanding ...
Mani Vigneshwaran V Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, - - 2013
A low cost, microfluidic paper electrochemical device (μPED) was fabricated using screen printing of electrodes and heat transfer of patterned wax paper onto filter paper. The μPED features films of a light-emitting ruthenium metallopolymer, microsomal metabolic enzymes, and DNA to detect potential genotoxic pollutant activity in environmental samples. Unlike conventional ...
Duffey Kiyah J KJ Carolina Population Center, Chapel Hill, North Carolina, - - 2013
Changes in total energy intake have been reported among children and adolescents, but the extent to which the components of total energy-energy density; portion size; and the number of eating/drinking occasions (EO)-drive these changes is unknown. The objective of the current study was to examine the relative contribution to changes ...
Baskin Monica L ML Division of Preventive Medicine, University of Alabama at Birmingham, 1717 11th Avenue South, MT 618, Birmingham, AL 35205, USA. - - 2013
African American adolescents residing in the South are at increased risk for obesity and physical inactivity, yet our understanding of potential influences is limited. Using an ecological framework, this study explored multilevel predictors (individual, family, home, and neighborhood environment) of moderate-to-vigorous physical activity (MVPA) among 116 African American adolescents (ages ...
Bjelic Sinisa - - 2013
The Morita-Baylis-Hillman reaction forms a carbon-carbon bond between the α-carbon of a conjugated carbonyl compound and a carbon electrophile. The reaction mechanism involves Michael addition of a nucleophile catalyst at the carbonyl β-carbon, followed by bond formation with the electrophile and catalyst disassociation to release the product. We used Rosetta ...
Snider Erik J EJ Department of Chemistry, Dartmouth College, Hanover, NH 03755, - - 2013
Using a collection of dye-labeled cytochrome c (cyt c) variants, we identify transformations of the heterogeneous cardiolipin (CL)-bound cyt c ensemble with added ATP. Distributions of dye-to-heme distances P(r) from time-resolved fluorescence resonance energy transfer show that ATP decreases the population of largely unfolded cyt c conformers, but its effects ...
Koner Apurba L AL Department of Biochemistry, Oxford University, South Parks Road, OX1 3QU, United Kingdom. - - 2013
Fluorescent nanoparticles have enabled many discoveries regarding how molecular machines function. Quantum dots have been the dominant class of fluorescent nanoparticles but suffer from blinking and from a substantial dark fraction--particles where the fluorescence is never seen--complicating any analysis of biological function. Nanoparticles composed of conjugated fluorescent polymers (Pdots) have ...
Yang Dachi - - 2013
The image shows an artistic version of a Pd nanowire surrounded by hydrogen molecules. The nanowire is electrically connected to the Pt electrodes of a sensor device by L. F. Fonseca and co-workers to study the effects of reduced temperature on its electrical response during hydrogen gas exposure. The TEM ...
Ravera Enrico E Department of Chemistry Ugo Schiff and Magnetic Resonance Center (CERM), University of Florence, 50019 Sesto Fiorentino (FI), - - 2013
Using the 480 kDa iron-storage protein complex, apoferritin (ApoF), as an example, we demonstrate that sizable dynamic nuclear polarization (DNP) enhancements can be obtained on sedimented protein samples. In sedimented solute DNP (SedDNP), the biradical polarizing agent is co-sedimented with the protein, but in the absence of a glass-forming agent. ...
Ságodi László - - 2013
Polycystic ovary syndrome is a heterogeneous disorder characterized by chronic ovulatory dysfunction and hyperandrogenism. It occurs in 6-8% of the female population in the reproductive age. The syndrome may be associated with various metabolic disorders which may impair the quality of life and life expectancy of patients. The diagnosis in ...
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