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Wilcox Sara S Department of Exercise Science, University of South Carolina, Columbia, 29208, USA. - - 2013
Faith-based interventions hold promise for promoting health in ethnic minority populations. To date, however, few of these interventions have used a community-based participatory research (CBPR) approach, have targeted both physical activity and healthy eating, and have focused on structural changes in the church. To report the results of a group ...
Baker Susan P SP Department of Health Policy and Management, Johns Hopkins University, Baltimore, Maryland, - - 2013
Recently, suicide exceeded motor vehicle crashes as the leading cause of injury death in the U.S. However, details of this change in suicide methods and the relationship to individual demographics, such as age and societal influences, have not been reported. To determine the characteristics of the changes in suicide rates ...
Slater Sandy J SJ Institute for Health Research and Policy, Chicago, Illinois, USA. - - 2013
Neighborhood design features have been associated with health outcomes, including the prevalence of obesity. This study examined the association between walkability and adolescent weight in a national sample of public secondary school students and the communities in which they live. Data were collected through student surveys and community observations between ...
Stoltz D J DJ University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, - - 2013
Specific patterns of allergic sensitization as well as quantification of the in vitro IgE response in early life may provide relevant clinical insight into future rhinitis and asthma risk. To define relationships among established sensitization to particular aeroallergens, quantitative analyses of allergen-specific IgE levels, pet exposure and sensitization, and asthma ...
Li Tiangang T Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272, - - 2013
Bile acids are signaling molecules that activate nuclear receptors, such as farnesoid X receptor, pregnane X receptor, constitutive androstane receptor, and vitamin D receptor, and play a critical role in the regulation of lipid, glucose, energy, and drug metabolism. These xenobiotic/endobiotic-sensing nuclear receptors regulate phase I oxidation, phase II conjugation, ...
Cascalho Marilia I MI Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. - - 2013
Scarcely anyone would dispute that donor-specific B cells and the Abs that they produce can cause rejection of transplants. Less clear and more controversial, however, is the possibility that donor-specific B cells and the Abs that they produce are one or more means by which transplants can be protected from ...
McDonald Caleb B CB Department of Biochemistry and Molecular Biology, Leonard Miller School of Medicine, University of Miami, Miami, FL 33136, - - 2013
Allostery plays a key role in dictating the stoichiometry and thermodynamics of multi-protein complexes driving a plethora of cellular processes central to health and disease. Herein, using various biophysical tools, we demonstrate that although Sos1 nucleotide exchange factor and Gab1 docking protein recognize two non-overlapping sites within the Grb2 adaptor, ...
Stroebele Nanette N University of Colorado Anschutz Medical Campus, Mailstop C263, 13001 E 17th Place, Aurora, CO 80045, USA. - - 2013
To improve support and justification for health promotion efforts in schools, it is helpful to understand how students' health behaviors affect academic performance. Fifth-grade students completed an online school-administered health survey with questions regarding their eating behavior, physical activity, academic performance, and sleep patterns. Differences in health behaviors were examined ...
Huynh Jimmy L JL Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, - - 2013
Clinical neurologists and scientists who study multiple sclerosis face open questions regarding the integration of epidemiological data with genome-wide association studies and clinical management of patients. It is becoming evident that the interplay of environmental influences and individual genetic susceptibility modulates disease presentation and therapeutic responsiveness. The molecular mechanisms through ...
Wen Ming M Department of Sociology, University of Utah, Lake City, UT 84112, USA. - - 2013
Little national evidence is available on spatial disparities in distributions of parks and green spaces in the USA. This study examines ecological associations of spatial access to parks and green spaces with percentages of black, Hispanic, and low-income residents across the urban-rural continuum in the conterminous USA. Census tract-level park ...
Hager Erin R ER Department of Pediatrics, Growth and Nutrition Division, University of Maryland School of Medicine, 737 West Lombard Street, Baltimore, MD 21201, USA. - - 2013
Neighborhood perceived/built environment and physical activity (PA) associations have been examined for adolescents around homes, but not surrounding schools. The purpose of this paper is to examine if positive perceptions/built environment in neighborhoods surrounding schools predict PA among low-income, urban adolescent girls. Measures include: minutes in moderate-vigorous PA (MVPA, ankle ...
Gerber Yariv Y Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, - - 2013
There is growing awareness of an association between cardiovascular disease and fractures, and a temporal increase in fracture risk after myocardial infarction has been identified. To further explore the nature of this relationship, we systematically examined the association of hip fracture with all disease categories and assessed related secular trends. ...
Slining Meghan M MM Department of Nutrition, University of North Carolina at Chapel Hill, - - 2013
Heretofore, corporate voluntary pledges to improve the health of Americans have been linked neither to explicit measurable commitments nor to a framework for an independent evaluation. The Healthy Weight Commitment Foundation (HWCF), whose members include 16 of the nation's leading consumer packaged goods food and beverage manufacturers, voluntarily pledged to ...
Khoo C C H CC Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO 80523, - - 2013
RNA interference (RNAi) is the major innate antiviral pathway in Aedes aegypti that responds to replicating arboviruses such as dengue virus (DENV) and Sindbis virus (SINV). On the one hand, the mosquito's RNAi machinery is capable of completely eliminating DENV2 from Ae. aegypti. On the other, transient silencing of key genes ...
Jiang Mengxi M Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, - - 2013
The constitutive androstane receptor (CAR, NR1I3) is a member of the nuclear receptor superfamily. Initially recognized as a xenobiotic receptor, CAR has been increasingly appreciated for its endobiotic functions in influencing glucose and lipid metabolism, whose dysregulations are implicated in the most prevalent metabolic disorders, such as obesity and type ...
Mani Vigneshwaran V Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, - - 2013
A low cost, microfluidic paper electrochemical device (μPED) was fabricated using screen printing of electrodes and heat transfer of patterned wax paper onto filter paper. The μPED features films of a light-emitting ruthenium metallopolymer, microsomal metabolic enzymes, and DNA to detect potential genotoxic pollutant activity in environmental samples. Unlike conventional ...
Reis Rodrigo S RS School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil. - - 2013
Physical inactivity plays a role in the acquisition of heart disease, type 2 diabetes, and breast and colon cancer. The impact of such noncommunicable diseases on low- and middle-income countries is a major global health concern, but most studies in this area have focused on high-income countries. A better understanding ...
Lax Nichola Z NZ Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, The Medical School, Newcastle University, Newcastle upon Tyne, - - 2013
Mitochondrial respiratory chain disease is associated with a spectrum of clinical presentations and considerable genetic heterogeneity. Here we report molecular genetic and neuropathologic findings from an adult with an unusual manifestation of mitochondrial DNA disease. Clinical features included early-onset cataracts, ataxia, and progressive paraparesis, with sequencing revealing the presence of ...
Gavala M L ML Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792-9988, - - 2013
Allergic airway inflammation contributes to the airway remodelling that has been linked to increased obstruction and morbidity in asthma. However, the mechanisms by which allergens contribute to airway remodelling in humans are not fully established. CCL18, chitotriosidase (CHIT1) and YKL-40 are readily detectable in the lungs and contribute to remodelling ...
Pulsford Richard M RM Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Devon, United Kingdom. - - 2013
Prospective studies report associations between indicators of time spent sitting and obesity risk. Most studies use a single indicator of sedentary behavior and are unable to clearly identify whether sedentary behavior is a cause or a consequence of obesity. To investigate cross-sectional and prospective associations between multiple sitting time indicators ...
Mani Sridhar S Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA. - - 2013
Adopted orphan nuclear receptor (NR), pregnane X receptor (PXR), plays a central role in the regulation of xeno- and endobiotic metabolism. Since the discovery of the functional role of PXR in 1998, there is evolving evidence for the role of PXR agonists in abrogating metabolic pathophysiology (e.g., cholestasis, hypercholesterolemia, and ...
Harolds Jay J Division of Radiology and Biomedical Imaging, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA. - - 2013
There are 2 major classes of feedback. One class of feedback consists of the informal, numerous conversations between various people in the organization regarding the performance, behavior, and goals of an individual. Another class of feedback consists of formal reviews held once or twice a year between a supervisor and ...
Dodson John A JA Section of Cardiology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, - - 2013
Despite the fact that 80% of patients with heart failure are aged more than 65 years, recognition of cognitive impairment by physicians in this population has received relatively little attention. The current study evaluated physician documentation (as a measure of recognition) of cognitive impairment at the time of discharge in ...
Beach Thomas G TG Banner Sun Health Research Institute, Sun City, Arizona 85351, USA. - - 2013
The clinical diagnosis of Parkinson disease (PD) is incorrect in 30% or more of subjects particularly at the time of symptom onset. Because Lewy-type α-synucleinopathy is present in the submandibular glands of PD patients, we assessed the feasibility of submandibular gland biopsy for diagnosing PD. We performed immunohistochemical staining for ...
Duffey Kiyah J KJ Carolina Population Center, Chapel Hill, North Carolina, - - 2013
Changes in total energy intake have been reported among children and adolescents, but the extent to which the components of total energy-energy density; portion size; and the number of eating/drinking occasions (EO)-drive these changes is unknown. The objective of the current study was to examine the relative contribution to changes ...
Bjelic Sinisa - - 2013
The Morita-Baylis-Hillman reaction forms a carbon-carbon bond between the α-carbon of a conjugated carbonyl compound and a carbon electrophile. The reaction mechanism involves Michael addition of a nucleophile catalyst at the carbonyl β-carbon, followed by bond formation with the electrophile and catalyst disassociation to release the product. We used Rosetta ...
Snider Erik J EJ Department of Chemistry, Dartmouth College, Hanover, NH 03755, - - 2013
Using a collection of dye-labeled cytochrome c (cyt c) variants, we identify transformations of the heterogeneous cardiolipin (CL)-bound cyt c ensemble with added ATP. Distributions of dye-to-heme distances P(r) from time-resolved fluorescence resonance energy transfer show that ATP decreases the population of largely unfolded cyt c conformers, but its effects ...
Koner Apurba L AL Department of Biochemistry, Oxford University, South Parks Road, OX1 3QU, United Kingdom. - - 2013
Fluorescent nanoparticles have enabled many discoveries regarding how molecular machines function. Quantum dots have been the dominant class of fluorescent nanoparticles but suffer from blinking and from a substantial dark fraction--particles where the fluorescence is never seen--complicating any analysis of biological function. Nanoparticles composed of conjugated fluorescent polymers (Pdots) have ...
Yang Dachi - - 2013
The image shows an artistic version of a Pd nanowire surrounded by hydrogen molecules. The nanowire is electrically connected to the Pt electrodes of a sensor device by L. F. Fonseca and co-workers to study the effects of reduced temperature on its electrical response during hydrogen gas exposure. The TEM ...
Ravera Enrico E Department of Chemistry Ugo Schiff and Magnetic Resonance Center (CERM), University of Florence, 50019 Sesto Fiorentino (FI), - - 2013
Using the 480 kDa iron-storage protein complex, apoferritin (ApoF), as an example, we demonstrate that sizable dynamic nuclear polarization (DNP) enhancements can be obtained on sedimented protein samples. In sedimented solute DNP (SedDNP), the biradical polarizing agent is co-sedimented with the protein, but in the absence of a glass-forming agent. ...
Ságodi László - - 2013
Polycystic ovary syndrome is a heterogeneous disorder characterized by chronic ovulatory dysfunction and hyperandrogenism. It occurs in 6-8% of the female population in the reproductive age. The syndrome may be associated with various metabolic disorders which may impair the quality of life and life expectancy of patients. The diagnosis in ...
Kabbage Maria - - 2013
The aim of this study was to evaluate calreticulin expression in infiltrating ductal breast carcinomas (IDCAs), as well as its relationships with clinicopathological parameters of the disease. Using a two-dimensional gel electrophoresis/matrix-assisted laser desorption ionization time of flight mass spectrometry investigation coupled to an immunohistochemical approach, we have assessed the ...
Uriarte G - - 2013
The aim of the study was to analyze the phenotypic and epigenetic changes induced by the shift to a chow diet after an obesogenic environment. Animals were randomized to fed chow (control group) or high-fat-sucrose diet (HFS). After 10 weeks, half of the rats fed with HFS diet were reassigned to ...
Anderko Laura - - 2013
Nurses and other health professionals are often asked about the benefits and risks of fish consumption. The combination of conflicting media messages about these risks and benefits and limited knowledge has led to confusion about how to properly advise people about safe fish consumption. "Fish Facts for Health Professionals" was ...
Kisfali Péter - - 2013
Larsen-syndrome is a rare genetic skeletal dysplasia belonging to the group of actin-binding filamin B associated diseases. The features include congenital dislocations of the large joints, scoliosis and cervical kyphosis, short, broad, spatulate distal phalanges, and distinctive craniofacies. Diagnosis is based on clinical and radiographic findings and confirmed by molecular ...
Rasineni Karuna - - 2013
High intake of dietary fructose has been shown to exert a number of adverse metabolic effects in humans and experimental animals. The present study was proposed to elucidate the effect of Catharanthus roseus (C. roseus) leaf powder treatment on alterations in carbohydrate and lipid metabolisms in rats fed with high-fructose ...
Lewenson Sandra B - - 2013
This article presents the use of a case story about a fictitious character, Professor Able, as a strategy to learn about the role of the nurse educator and to assist in the transition from clinical practice into that role. The story evolves over a 13-week semester in an engaging, asynchronous ...
Shen Xinqian - - 2013
A Tn5 transposition vector, pMOD-tet-egfp, was constructed and used for the random insertional mutagenesis of Bacillus pumilus. Various parameters were investigated to increase the transformation efficiency B. pumilus DX01 via Tn5 transposition complexes (transposome): bacterial growth phase, type of electroporation buffer, electric field strength, and recovery medium. Transformation efficiency was ...
Wang Meimei - - 2013
Business Intelligence (BI) has caused extensive concerns and widespread use in gathering, processing and analyzing data and providing enterprise users the methodology to make decisions. Different from traditional BI architecture, this paper proposes a new BI architecture, Top-Down Scalable BI architecture with defining mechanism for enterprise decision making solutions and ...
Shahin Saba - - 2013
The present experiment was designed to study the 2.45 GHz low-level microwave (MW) irradiation-induced stress response and its effect on implantation or pregnancy in female mice. Twelve-week-old mice were exposed to MW radiation (continuous wave for 2 h/day for 45 days, frequency 2.45 GHz, power density = 0.033549 mW/cm(2), and specific absorption rate = 0.023023 W/kg). At the end of ...
Boehm Laura B - - 2013
Traditionally, the new graduate registered nurse (RN) transition has included a didactic and skills-based orientation accompanied by a period of preceptored practice. However, these methods do not ensure that new RNs are in a state of reduced anxiety to fully interact with their new environment. Transition to practice may cause ...
Tomcsányi János - - 2013
The authors report the spiked helmet ST-segment elevation in two patients in order to draw attention to this high-risk electrocardiographic sign. This form of ST-segment elevation needs an urgent evaluation and management of the critically ill patient. Orv. Hetil., 2013, 154, 147-149.
Devers Patricia L - - 2013
The 1997 discovery of free fetal DNA in maternal plasma launched clinical researchers' efforts to establish a reliable method for non-invasive prenatal testing for fetal genetic conditions. Various methods, including, but not limited to, massively parallel sequencing (MPS) and selective analysis of cell-free fetal DNA in maternal plasma, have recently ...
Sári Eszter - - 2013
Hairy cell leukemia is a mature B-cell non-Hogkin lymphoma characterized by unique clinical, morphological and immunhistochemical features. Patients with hairy cell leukemia usually present with splenomegaly, progressive pancytopenia and a relative indolent clinical course. The diagnosis does not always indicate immediate treatment, as treatment depends on the clinical stage of ...
Csaba György - - 2013
The notion of the perinatal "hormonal imprinting" has been published at first in 1980 and since that time it spred expansively. The imprintig develops at the first encounter between the developing receptor and the target hormone - possibly by the alteration of the methylation pattern of DNA - and it ...
Huang Jin - - 2013
The outgrowth of root hairs from the epidermal cell layer is regulated by a strict genetic regulatory system and external growth conditions. Rice plants cultivated in water-logged paddy land are exposed to a soil ecology that differs from the environment surrounding upland plants, such as Arabidopsis and maize. To identify ...
Komnenich Pauline - - 2013
The Nursing Education Exchange (NEXus) is a consortium of academic doctoral programs in nursing, initiated in response to a national shortage of well-qualified nurse educators and the need to increase the number of doctoral faculty in nursing programs across the United States. The vision for the consortium was to use ...
Ahantarig Arunee - - 2013
The symbiotic microorganisms of arthropod vectors are highly significant from several points of view, partly due to their possible roles in the transmission of pathogenic causative agents by blood-sucking vectors. Although ticks are well studied because of their significance to human health, novel microbial associations remain to be described. This ...
Johnson Eric O - - 2013
A great promise of publicly sharing genome-wide association data is the potential to create composite sets of controls. However, studies often use different genotyping arrays, and imputation to a common set of SNPs has shown substantial bias: a problem which has no broadly applicable solution. Based on the idea that ...
Towsley Gail L - - 2013
We examined the effect of market and organizational characteristics on nursing home quality as measured by deficiencies (number and weighted) on states in a rural region of the United States. Rural nursing homes in five Mountain West states (N = 161) were sampled from the Online Survey Certification and Reporting ...
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