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Vasu Sumithira S Division of Hematology, The Ohio State University, Columbus, Ohio, USA. - - 2013
We summarize recent advances for acute myeloid leukemia (AML) in older patients, with a focus on immunotherapeutics. Although the recently updated US SEER data still show that the majority of older AML patients do not receive any therapy, this reality is slowly changing. Advances in our understanding of the biology ...
Myers Samuel A SA Department of Pharmaceutical Chemistry, UCSF, San Francisco, CA, - - 2013
The development of electron-based, unimolecular dissociation MS, i.e. electron capture and electron transfer dissociation (ECD and ETD, respectively), has greatly increased the speed and reliability of labile PTM site assignment. The field of intracellular O-GlcNAc (O-linked N-acetylglucosamine) signaling has especially advanced with the advent of ETD MS. Only within the ...
Suzuki Yuichiro J - - 2013
Substantial experimental evidence suggests the usefulness of antioxidants for the treatment of various forms of pulmonary hypertension. However, no recommendations have yet been made if patients with pulmonary hypertension should receive pharmacologic and/or dietary antioxidants. Our understanding of antioxidants has evolved greatly over the last two decades, from the primitive ...
Mamode Nizam N Department of Transplantation, Guys Hospital, London, UK. - - 2013
Anonymity of donors or recipients in living-donor transplantation is a complex issue and practice varies widely. There are compelling arguments for maintaining anonymity of both parties before unspecified donor transplantation and specified indirect transplantation. After transplantation, there are still good reasons to avoid disclosure of identities. Although anonymity could be ...
Amaral W Z WZ Harlow Center for Biological Psychology, University of Wisconsin-Madison, Madison, WI 53715, USA. - - 2013
Individual variation in serotonergic function is associated with reactivity, risk for affective disorders, as well as an altered response to disease. Our study used a nonhuman primate model to further investigate whether a functional polymorphism in the promoter region for the serotonin transporter gene helps to explain differences in proinflammatory ...
Nandi Pradyot P Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, - - 2013
An all-PDMS on-line microdialysis-microchip electrophoresis with on-chip derivatization and electrophoretic separation for near real-time monitoring of primary amine-containing analytes is described. Each part of the chip was optimized separately, and the effect of each of the components on temporal resolution, lag time, and separation efficiency of the device was determined. ...
Lai Xianyin X Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. - - 2013
The proportionately low abundance of membrane proteins hampers their proteomic analysis, especially for a quantitative LC-MS/MS approach. To overcome this limitation, a method was developed that consists of one cell disruption step in a hypotonic reagent using liquid nitrogen, one isolation step using a low speed centrifugation, and three wash ...
Na Hee-Kyung - - 2013
To date, graphene oxide (GO), an oxidized version of graphene, has been utilized in many research areas including bioapplications such as drug delivery and bioanalysis. Unlike other spherical or polygonal nanomaterials, GO exhibits a sheet-like structure, which in itself suggests interesting applications based on its shape. Here we show that ...
Pelaseyed Thaher T Department of Medical Biochemistry, University of Gothenburg, Gothenburg, - - 2013
MUC1 and other membrane-associated mucins harbor long, up to 1 μm, extended highly glycosylated mucin domains and sea urchin sperm protein, enterokinase and agrin (SEA) domains situated on their extracellular parts. These mucins line luminal tracts and organs, and are anchored to the apical cell membrane by a transmembrane domain. ...
Li Hongli H Department of Chemistry, Washington State University, Pullman, Washington 99164, United - - 2013
A high resolution ion mobility spectrometer was interfaced to a Synapt G2 high definition mass spectrometer (HDMS) to produce IMMS-IMMS analysis. The hybrid instrument contained an electrospray ionization source, two ion gates, an ambient pressure linear ion mobility drift tube, a quadrupole mass filter, a traveling wave ion mobility spectrometer ...
Ramoni Angela A Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria. - - 2013
Prenatal diagnosis of placenta increta and percreta is essential to avoid potentially life-threatening hemorrhage by optimizing peripartal management. Invasive placentation presents significant challenges at cesarean section even for highly skilled surgeons. In the four cases of placenta increta/percreta presented here we tried to avoid hysterectomy by leaving the placenta behind ...
Bergauer Kristin - - 2013
Recently, evidence suggests that dark CO2 fixation in the pelagic realm of the ocean does not only occur in the suboxic and anoxic water bodies but also in the oxygenated meso- and bathypelagic waters of the North Atlantic. To elucidate the significance and phylogeny of the key organisms mediating dark ...
Yu Shann S SS Department of Biomedical Engineering, Vanderbilt University , Nashville, Tennessee 37235, - - 2013
Macrophages represent an important therapeutic target, because their activity has been implicated in the progression of debilitating diseases such as cancer and atherosclerosis. In this work, we designed and characterized pH-responsive polymeric micelles that were mannosylated using "click" chemistry to achieve CD206 (mannose receptor)-targeted siRNA delivery. CD206 is primarily expressed ...
Rapraeger Alan C AC Department of Human Oncology, University of Wisconsin-Madison, WI 53705, USA. - - 2013
Vascular endothelial growth factor (VEGF)-stimulated angiogenesis depends on a cross-talk mechanism involving VEGF receptor 2 (VEGFR2), vascular endothelial (VE)-cadherin and the αVβ3 integrin. Because we have shown that αVβ3 integrin activation is dependent on its incorporation, along with the insulin-like growth factor-1 receptor (IGF1R) kinase, into a ternary receptor complex ...
Haynes Stuart W SW Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, - - 2013
Ardeemins are hexacyclic peptidyl alkaloids isolated from Aspergillus fischeri as agents that block efflux of anticancer drugs by MultiDrug Resistance (MDR) export pumps. To evaluate the biosynthetic logic and enzymatic machinery for ardeemin framework assembly, we sequenced the A. fischeri genome and identified the ardABC gene cluster. Through both genetic ...
Cushing Kevin W KW Department of Chemical and Nuclear Engineering, Center for Biomedical Engineering, The University of New Mexico, Albuquerque, New Mexico 87131, United - - 2013
This report describes the development of elastomeric capture microparticles (ECμPs) and their use with acoustophoretic separation to perform microparticle assays via flow cytometry.We have developed simple methods to form ECμPs by cross-linking droplets of common commercially available silicone precursors in suspension followed by surface functionalization with biomolecular recognition reagents. The ...
Christensen Ronald L RL Department of Chemistry, Bowdoin College, Brunswick, Maine 04011, USA. - - 2013
Steady-state and ultrafast transient absorption spectra were obtained for a series of conformationally constrained, isomerically pure polyenes with 5-23 conjugated double bonds (N). These data and fluorescence spectra of the shorter polyenes reveal the N dependence of the energies of six (1)B(u)(+) and two (1)A(g)(-) excited states. The (1)B(u)(+) states ...
McMillan Andrew W AW Department of Biochemistry, University of Washington, Seattle, Washington 98195, - - 2013
The quantum yield of tryptophan (Trp) fluorescence was measured in 30 designed miniproteins (17 β-hairpins and 13 Trp-cage peptides), each containing a single Trp residue. Measurements were made in D(2)O and H(2)O to distinguish between fluorescence quenching mechanisms involving electron and proton transfer in the hairpin peptides, and at two ...
Kim Hae Won - - 2013
The study aimed to evaluate the efficacy of PET/CT in detecting peritoneal carcinomatosis in patients with ovarian cancer and to compare the diagnostic accuracy of FDG PET/CT with that of enhanced abdominal CT. The medical records of 46 consecutive patients with ovarian cancer were reviewed, and the presence of peritoneal ...
Lopci Egesta - - 2013
ABSTRACT: Herein we report the case of a 45-year-old woman with known history of malignant melanoma, complaining recent onset of bilateral hearing problems initially addressed to acoustic neuroma. Dedicated F-FDG PET/CT and MR imaging documented the presence of 3 areas of pathologic uptake in the V-VII-VIII cranial nerves, other 2 ...
Gutiérrez-Magdaleno Gabriel - - 2013
Unlike most small globular proteins, lipocalins lack a compact hydrophobic core. Instead, they present a large central cavity that functions as the primary binding site for hydrophobic molecules. Not surprisingly, these proteins typically exhibit complex structural dynamics in solution, which is intricately modified by intermolecular recognition events. Although many lipocalins ...
Edlow Jonathan A - - 2013
Acute neurological symptoms in pregnant and post-partum women could be caused by exacerbation of a pre-existing neurological condition, the initial presentation of a non-pregnancy-related problem, or a new acute-onset neurological problem that is either unique to or occurs with increased frequency during or just after pregnancy. Pregnant and postpartum patients ...
Joa Kyung-Lim - - 2013
The aim of this study was to understand the meaning of the double-peak responses in digital nerve conduction study in normal and diabetic patients. This was a cross-sectional and correlative study. Sixty healthy subjects (10 people per decade from 20 to 79 yrs of age; 26 men; mean age, 48 ...
Nokes Kathleen M - - 2013
The purpose of this preliminary work was to develop a new short tool to assess personal health records (PHRs) self-efficacy. Prior work had found 4 distinct skills related to creating, updating, tracking symptoms, and sharing information with health care providers using PHR. Although PHRs have great promise, their uptake has ...
Ito Kimiteru - - 2013
ABSTRACT: A 65-year-old woman with a complete atrioventricular block was diagnosed as having cardiac sarcoidosis. F-FDG PET/CT imaging without unfractionated heparin loading revealed systemic abnormal uptake indicating sarcoidosis. However, the cardiac lesions were vague because of the physiological FDG uptake. One month later, F-FDG PET/CT using heparin loading was performed ...
Celik Ugur - - 2013
To assess the safety, predictability, and stability of a new microwave thermokeratoplasty procedure to correct myopia. Cornea and refractive surgery subspecialty. Prospective clinical trial. Thermokeratoplasty was performed in myopic eyes at a single center in Turkey from June 2009 to June 2010. The attempted corrections ranged from -1.25 to -5.75 ...
Klukowska-Rötzler Jolanta - - 2013
Background -  In humans, thymic stromal lymphopoietin (TSLP) plays a central role in the development of allergic inflammation, such as atopic dermatitis (AD), but it is unknown whether it is involved in the pathogenesis of canine AD (CAD). Hypothesis/Objectives -  Our aim was to characterize canine TSLP and to assess its expression ...
Donovan Geoffrey H - - 2013
Several recent studies have identified a relationship between the natural environment and improved health outcomes. However, for practical reasons, most have been observational, cross-sectional studies. A natural experiment, which provides stronger evidence of causality, was used to test whether a major change to the natural environment-the loss of 100 million ...
Vicenzi E - - 2013
The strategy of all retroviral infections is based on establishing an equilibrium between virus replication and proviral latency in the infected host. The human immunodeficiency virus-type 1 (HIV-1), belonging to the subfamily of lentiviridae, adds an additional level of sophistication to this general rule by encoding two regulatory genes (tat ...
Ravera Iván - - 2013
Background - It is unproven that all dogs harbour Demodex mites in their skin. In fact, several microscopic studies have failed to demonstrate mites in healthy dogs. Hypothesis/Objectives - Demodex canis is a normal inhabitant of the skin of most, if not all, dogs. This hypothesis was tested using a ...
Duncan Scott - - 2013
GPS receivers are becoming increasingly common as an objective measure of spatiotemporal movement in free-living populations; however, research into the effects of the surrounding physical environment on the accuracy of off-the-shelf GPS receivers is limited. The goal of the current study was to (1) determine the static validity of seven ...
Bieze Matthanja - - 2013
ABSTRACT: Hepatoblastoma is a rare carcinoma mostly seen in children. Neoadjuvant chemotherapy followed by resection and adjuvant chemotherapy is the optimal treatment. We present the case of an 18-year-old woman who presented with abdominal pain, nausea, bloating, and fatigue. MRI showed 3 hepatic lesions with high signal intensity on arterial ...
Busatti Haendel G N O - - 2013
The chemotherapeutic agents used for the treatment of giardiasis are often associated with adverse side effects and are refractory cases, due to the development of resistant parasites. Therefore the search for new drugs is required. We have previously reported the giardicidal effects of metronidazole (MTZ) and its analogues (MTZ-Ms, MTZ-Br, ...
Sinz Michael W - - 2013
The increased capacity to rapidly eliminate drugs can have a profound effect on the efficacious exposure of coadministered drugs, especially in today's medical world of polypharmacy. There are numerous drug-drug interactions (DDIs) related to a loss of therapeutic efficacy and many of these are caused by pregnane X receptor (PXR)-mediated ...
Kobayashi Tetsuro - - 2013
Background -  Keratinocytes in the hair follicle bulge region have a high proliferative capacity, with characteristics of epithelial stem cells. This cell population might thus be an ideal source for generating the interfollicular epidermis in a canine skin equivalent. Hypothesis/Objectives -  This study was designed to determine the ability of canine hair ...
Bexley Jennifer - - 2013
Background -  Dogs and humans with atopic dermatitis (AD) are predisposed to colonization and recurrent infection with Staphylococcus spp. Studies in humans suggest that staphylococcus-specific immunoglobulin E (IgE) plays a key role in disease pathogenesis. Few such studies have been undertaken in dogs. Hypothesis/Objectives -  The aim of this study was to compare ...
Malhotra Gaurav - - 2013
ABSTRACT: A 48-year-old male patient of papillary carcinoma of thyroid, who had received 3.145 GBq of radioiodine (I) 6 months earlier, presented with recurrent headaches and progressively worsening double vision for 2 weeks. Iodine avid and low metabolic parasellar mass was seen on I SPECT/CT and F-FDG PET/CT, respectively. In ...
Olivry Thierry - - 2013
Background -  The management of atopic dermatitis (AD) in dogs relies mainly on the use of interventions to reduce pruritus and skin lesions. Objectives -  To provide a critical analysis of recent clinical trials reporting the efficacy and safety of interventions for canine AD. Methods -  Systematic review of randomized ...
Martin Pamela D - - 2013
Skin cancer is one of the most commonly diagnosed cancers in the world today in both humans and our pet population. Advances in molecular techniques are now affording us an opportunity to develop therapeutics targeted at specific cancer-related cellular pathways. However, despite progress in conventional treatments, such as chemotherapy and ...
Kolodziejczyk-Czepas Joanna - - 2013
Clovers (genus: Trifolium) have been used in traditional medicine by many cultures, but the biological activity of the most of these plants still remains unknown. The aim of our in vitro study was to assess the antioxidative action of phenolic extracts from aerial parts of Trifolium scabrum and Trifolium pallidum ...
Lindeman Brenessa M - - 2013
Medical students commonly enroll in courses known as "subinternships" before residency application. This study investigated the experiences and needs of students completing subinternships in surgery. Electronic surveys were sent to medical students applying to the surgery residency program at our institution and to medical student clerkship directors for distribution nationally. ...
Jin Xiaona - - 2013
ABSTRACT: PET/CT scan was performed in a 43-year-old woman to evaluate pulmonary nodules/masses. The images showed that there was only minimal FDG activity in the masses. However, these soft tissue masses in the lungs had significantly elevated Tc 3PRGD2 activity. Pathological examination demonstrated that this patient suffered benign metastasizing leiomyoma.
Källén Bengt - - 2013
Maternal use of some drugs, notably paracetamol and drugs for gastroesophageal reflux, has been associated with an increased risk of childhood asthma in the child. We wanted to analyze these associations with consideration to the confounding of maternal asthma. Childhood asthma was identified from the Swedish National Prescription Register and ...
Savytskyi Oleksandr V - - 2013
Human tyrosyl-tRNA synthetase (HsTyrRS) is composed of two structural modules: N-terminal catalytic core and an EMAP II-like C-terminal domain. The structures of these modules are known, but no crystal structure of the full-length HsTyrRS is currently available. An all-atom model of the full-length HsTyrRS was developed in this work. The ...
Pollak Amy W - - 2013
Evaluation of peripheral arterial disease by cardiovascular magnetic resonance imaging continues to develop. Of the clinical diagnostics tests currently available, magnetic resonance angiography is well established as one of the preferred techniques for determining areas of arterial occlusive disease affecting the lower extremities. Despite this, there have been new developments ...
Gilreath Tamika D - - 2013
Young people in military-connected families may be exposed to deleterious stressors, related to family member deployment, that have been associated with externalizing behaviors such as substance use. Substance use predisposes youth to myriad health and social problems across the life span. This study examined the prevalence and correlates of lifetime ...
Hommel-Berrey G A - - 2013
The novel allele HLA-DRB1*09:20 differs from HLA-DRB1*09:01:02 by one nucleotide substitution at codon 9 (AAG->CAG) and differs from HLA-DRB1*09:07 by one nucleotide substitution at codon 13 (TAT->TTT).
Bongiovanni Laura - - 2013
Background -  Epithelial-to-mesenchymal transition (EMT) is a multistep process, important in tumour invasion and metastasis, characterized by loss of epithelial markers, redistribution of β-catenin and gain of mesenchymal markers. Hyposthesis/Objectives -  Our aim was to investigate the immunohistochemical aberrant expression of cytokeratin, vimentin, survivin and heat shock protein 72 (Hsp72) in ...
Diehl Kevin - - 2013
ABSTRACT: Primary hepatic lymphoma (PHL) is an extremely rare manifestation of extranodal non-Hodgkin's lymphoma (0.016% of all cases). Presented are CT, MRI, ultrasound, and F fluoro-2-deoxy-D-glucose (FDG) PET/CT images, which characterized PHL and demonstrated hepatic vein thrombus that extended into the inferior vena cava-a feature not previously described. Recognition of ...
Raucy Judy L - - 2013
The evolution of scientific information relating to the regulation of xenobiotic disposition has extended to the discovery of an intricate group of receptor systems now recognized as master regulators. These ligand-activated transcription factors are commonly designated as "nuclear receptors", and include CAR (NR1I3), PXR (NR1I2), PPAR (NR1C1, NR1C2, and NR1C3) ...
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