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Vlachostergios Panagiotis J - - 2013
The efficacy of treatment for glioblastoma multiforme is currently limited by the development of resistance, particularly, but not exclusively, due to the expression of the DNA repair enzyme O6-methylguanine methyltransferase (MGMT) in a significant proportion of astrocytic tumors. MGMT is post-translationally regulated by the 26S proteasome, a multi-subunit organelle responsible ...
Khorshid Mohsen - - 2013
We introduce a biophysical model of miRNA-target interaction and infer its parameters from Argonaute 2 cross-linking and immunoprecipitation data. We show that a substantial fraction of human miRNA target sites are noncanonical and that predicted target-site affinity correlates well with the extent of target destabilization. Our model provides a rigorous ...
Cairns Andrew B - - 2013
The counterintuitive phenomenon of negative linear compressibility (NLC) is a highly desirable but rare property exploitable in the development of artificial muscles, actuators and next-generation pressure sensors. In all cases, material performance is directly related to the magnitude of intrinsic NLC response. Here we show the molecular framework material zinc(II) ...
Jaarsma Pier - - 2013
A preimplantation genetic test to discriminate between severe and mild autism spectrum disorder might be developed in the foreseeable future. Recently, the philosophers Julian Savulescu and Guy Kahane claimed that there are strong reasons for prospective parents to make use of such a test to prevent the birth of children ...
Jaunzeme J - - 2013
Using data obtained from a statutory health insurance (AOK) in the federal state of Lower Saxony, this study examined whether there were differences between the insured population compared with that of Lower Saxony (Niedersachsen) and of Germany with respect to social structural characteristics. Data for the comparisons were provided by ...
Eslamian Ladan - - 2013
The purpose of this study was to assess the effect of 810-nm (DMC Equipamentos, Sao Carlos, Brazil) continuous wave low-level laser therapy (LLLT) on the pain caused by orthodontic elastomeric separators. Thirty-seven orthodontic patients (12 male and 25 female, aged 11-32 years, mean age = 24.97 years) participated in the study, including 20 subjects ...
Messens Joris - - 2013
The major function of disulfide bonds is not only the stabilization of protein structures. Over the last 30 years, a change in perspective took place driven by groundbreaking experiments, which promoted disulfide bonds to central players in essential thiol disulfide exchange reactions involved in signal transduction, thiol protection and redox ...
Xiao-Jian Gu - - 2013
OBJECTIVE: To provide appropriate evidence for treatment planning of patients with an impacted proximal ureteral stones ≥1.5 cm in size, by analyzing the therapeutic outcomes for those undergoing minimally invasive percutaneous antegrade ureterolithotripsy and retrograde ureterolithotripsy. PATIENTS AND METHODS: From September 2010 to November 2011, eligible patients with impacted proximal ureteral ...
Gomes Joana - - 2013
The burden of stroke is increasing in developing countries that struggle to manage it efficiently. We identified determinants of early case-fatality among stroke patients in Maputo, Mozambique, to assess the impact of in-hospital complications. Patients admitted to any hospital in Maputo with a new stroke event were prospectively registered (n = 651) ...
Zhang Yujian - - 2013
Adapting to hypoxic stress is pivotal in tumor progression and determining tumor malignancy. The transcriptional factor hypoxia inducing factor (HIF) is crucial in modulating tumorous hypoxic responses through altering cell energy metabolism, which includes the modification on glucose and lipid metabolism associated gene expression. Stearoyl-CoA desaturase-1 (SCD1) is the main ...
Tovar Alison - - 2013
The goal of this paper is to describe the baseline characteristics of Live Well (intervention to prevent weight gain in recent immigrant mother-child dyads from Brazil, Haiti, and Latin America) participants, and to explore self-reported changes in diet and physical activity post-immigration. Baseline data from 383 mothers were used for ...
Marzano Angelo V - - 2013
Pyoderma gangrenosum (PG) and Sweet's syndrome (SS) are skin diseases usually presenting with recurrent ulcers and erythematous plaques, respectively. The accumulation of neutrophils in the skin, characteristic of these conditions, led to coin the term of neutrophilic dermatoses to define them. Recently, neutrophilic dermatoses have been included in the group ...
Ghashghaei S - - 2013
AIMS: The aim of this research was production of polyphosphate (poly P) and study on its antibacterial effects. METHODS AND RESULTS: Poly P granules in the cells were observed with the help of Albert staining and extracted by Mussig-Zufika method. TLC and nuclear magnetic resonance spectroscopy ((31) P NMR) used ...
Prasad Rajniti - - 2013
OBJECTIVE: To evaluate the role of serum procalcitonin (PCT) in diagnosis of septic meningitis in children and its efficacy in differential diagnosis. METHODS: The study included 40 children of septic meningitis admitted in pediatric ward with fever, headache, vomiting and seizure, up to 14 y of age. The diagnosis of septic ...
Bassegoda Arnau - - 2013
Rhodococci are highly adaptable bacteria, capable to degrade or transform a large number of organic compounds, including recalcitrant or toxic products. However, little information is available on the lipases of the genus Rhodococcus, except for LipR, the first lipase isolated and described from strain Rhodococcus CR-53. Taking into consideration the ...
Hamilton D W - - 2013
We aimed to investigate the factors contributing to poor recruitment to the EaStER trial "Early Stage glottic cancer: Endoscopic excision or Radiotherapy" feasibility study. We performed a prospective qualitative assessment of the EaStER trial at three centres to investigate barriers to recruitment and implement changes. Methods used included semi-structured interviews, ...
Ferreira P H - - 2013
Twin studies are becoming popular to investigate risk factors for low back pain (LBP) because they consider the genetic factor and allow for more precise estimates of risks. We aimed to identify and summarize the results of studies based on twin samples investigating risk factors for LBP. The MEDLINE, CINAHL, ...
Sasaki Atsushi - - 2013
Glioma-infiltrating microglia/macrophages are referred to as tumor-associated macrophages (TAMs). Transgenic (TG) rats expressing v-erbB, which is a viral form of the epidermal growth factor receptor, under transcriptional regulation by the S100-β promoter, develop brain tumors. This study was designed to clarify the pathological characteristics of TAMs in these experimental tumors. ...
Tavassoli Setareh - - 2013
The production of highly efficient, recyclable and cost-effective enzymes is one of the most important goals in industrial biotechnology. Bacterial spores are highly resistant to harsh environmental conditions, easy to produce and are suitable for manipulation of genetic materials. These features make them a very efficient tool for biotechnology. Here, ...
Abuzenadah Adel M - - 2013
We describe in this report a case of a 6-years-old female who presented at the age of 1 month with a mucocutaneous bleeding and suspected thrombocytopenia. The patient's condition was refractory to the known idiopathic thrombocytopenic purpura treatments and congenital form of Thrombocytopenia was suspected following the delivery of a male ...
D'Amelio Patrizia - - 2013
We report the prevalence of osteoporosis, osteopenia, and fractures in a cohort of Italian women randomly recruited among the general population and validate the use of clinical guidelines in referring women for bone density testing. We enrolled in the study 995 healthy women (age range 45-92 years). A bone density test ...
Ferro Mark A - - 2013
PURPOSE: The present study investigated the higher-order summary factor structure of the Child Health Questionnaire Parent Form-50 (CHQ) in a sample of children with new-onset epilepsy. The secondary aim was to identify risk factors predicting health-related quality of life (HRQL) 24 months post-diagnosis. METHODS: Data came from the Health-related Quality of ...
Tufan Abdurrahman - - 2013
Enthesopathy is pathology of bony insertions of tendons, ligaments or joint capsules. It is a frequent finding in rheumatic diseases, like ankylosing spondylitis (AS) and Behçet's disease. Musculoskeletal complaints are common in patients with familial Mediterranean fever (FMF), and these could be a clinical manifestation of enthesopathy. Hence, we investigated ...
Neil Bateman - - 2013
BACKGROUND: Speech and language delay is a common developmental disorder. Persistent delay may lead to adverse effects on literacy, educational achievement and psychosocial development. Affected children are commonly referred to the Otolaryngologist, hence a structured management approach is required to facilitate diagnosis and allow for early intervention and improved outcomes. ...
Shen Bing - - 2013
Store-operated Ca(2+) entry (SOCE) is a common and ubiquitous mechanism regulating Ca(2+) influx into cells and participates in numerous biological processes including cell proliferation. Glomerular mesangial cells (GMCs) play a role in the regulation of the glomerular filtration rate. From a clinical point of view, many physiological functions alter with ...
Guo Tingting - - 2013
Three putative promoter regions were identified preceding the nisZ gene in Lactococcus lactis HSM-22. To investigate their function in the control of nisZ biosynthesis, green fluorescence protein (GFP) was adopted as probe to determine activities of the three promoters. The results showed that PnisZ-0 containing two sets of the -35 ...
Borges Vanessa - - 2013
Cohesion between sister chromatids, mediated by the chromosomal cohesin complex, is a prerequisite for their alignment on the spindle apparatus and segregation in mitosis. Budding yeast cohesin first associates with chromosomes in G1. Then, during DNA replication in S-phase, the replication fork-associated acetyltransferase Eco1 acetylates the cohesin subunit Smc3 to ...
Schrader Kevin K - - 2013
The Gram-negative bacterium Flavobacterium columunare is the cause of colmunaris disease in channel catfish (Ictalurus punctatus). In a previous study, the betaine-type alkaloid ungeremine, 1 obtained from Pancratium maritimum L. was found to have strong antibacterial activity against F. columnare. In this study, analogues of 1 were evaluated using a ...
Sekiya Takashi - - 2013
Regulatory T cells (T(reg) cells) develop from progenitor thymocytes after the engagement of T cell antigen receptors (TCRs) with high-affinity ligands, but the underlying molecular mechanisms are still unclear. Here we show that the Nr4a nuclear receptors, which are encoded by immediate-early genes upregulated by TCR stimulation in thymocytes, have ...
Hagan Donald L - - 2013
We conducted a greenhouse study to assess the effects of cogongrass (Imperata cylindrica) rhizochemicals on a suite of plants native to southeastern US pine savanna ecosystems. Our results indicated a possible allelopathic effect, although it varied by species. A ruderal grass (Andropogon arctatus) and ericaceous shrub (Lyonia ferruginea) were unaffected ...
Fernández-Rodríguez Santiago - - 2013
This study aims to determine the potential origin of Olea pollen recorded in Badajoz in the Southwest of the Iberian Peninsula during 2009-2011. This was achieved using a combination of daily average and diurnal (hourly) airborne Olea pollen counts recorded at Badajoz (south-western Spain) and Évora (south-eastern Portugal), an inventory ...
Hocqueloux Laurent - - 2013
OBJECTIVES: To characterize viro-immunological outcomes following long-term combined antiretroviral therapy (cART) initiated during primary HIV infection (PHI) or chronic HIV infection (CHI) and to identify factors predictive of optimal viro-immunological responder (OVIR) status. METHODS: This was a prospective, single-centre cohort study of HIV-1-infected patients on effective cART. Total cell-associated HIV ...
Weng Wei - - 2013
A one-step, eco-friendly ultrasound-assisted process is established for the rapid synthesis of sulfur-carbon composite cathode materials, avoiding the widely used, energy inefficient "melt-down" process for Li-S batteries. It is demonstrated that, without inserting sulfur into pores of carbon, the coulombic efficiency of SC/Li cell in the new DOL/D2 electrolyte is ...
Martínez-Villalba Anna - - 2013
Veterinary medicines are widely administered to farm animals since they keep animals healthy at overcrowded conditions. Nevertheless the continuous administration of medicines to farm animals can frequently lead to the presence of residues of veterinary drugs in consumption products. Amprolium is a quaternary ammonium compound used in the treatment of ...
Arısoy Ozden - - 2013
There is a high co-morbidity between chronic inflammatory disorders and depression. Proinflammatory cytokines like TNF-α seem to play a central role in the pathogenesis of these disorders, and its neutralization provides a potent treatment for inflammatory disorders. Few studies showed that TNF-α blockers also caused an improvement in depressive symptoms ...
Montalbán Raúl - - 2013
BACKGROUND: To analyze and compare the relationship between anterior and posterior corneal shape evaluated by a tomographic system combining the Scheimpflug photography and Placido-disc in keratoconus and normal healthy eyes, as well as to evaluate its potential diagnostic value. METHODS: Comparative case series including a sample of 161 eyes of ...
Dzwigałowska A - - 2013
BACKGROUND/PURPOSE: One of the constantly developing fields in the area of cosmetology is the analysis of the efficacy of cosmetics products. Various instrumental techniques are available nowadays to evaluate changes in skin surface and measure anti-wrinkle activity. The aim of our study was to present and confront two methods of ...
Pillai Pramod P - - 2013
Regular arrays of nanorods having asymmetric cross-sections are fabricated by a combination of electrodeposition and glancing-angle deposition (GLAD). When these nanorods are embedded in a polymer matrix, they give rise to composite materials in which the structural anisotropy at the nanoscale translates into functional anisotropy in the form of direction-dependent ...
Schalek Petr - - 2013
Mucosal maxillary cysts (MMCs) are usually asymptomatic and are often diagnosed as an incidental finding. The aim of this study is to assess clinical significance of MMCs and the long-term effect of surgical treatment on the symptoms initially addressed to MMCs. The study included a retrospective analysis of 64 patients ...
Yu A - - 2013
Prostaglandin and prostamide analogues belong to a new substance group which came into the market in the 1990s. They have revolutionised antiglaucomatous therapy by their once-daily dosing regimen and fewer side effects. Today, prostaglandin and prostamide analogues are approved as first-line therapy for patients with primary open-angle glaucoma and ocular ...
Lagrow Alec P - - 2013
Branched metal nanostructures are of great technological importance because of their unique size- and shape-dependent properties. A kinetically controlled synthesis that uses polymorphism to produce branched nickel nanoparticles is presented. These nanoparticles consist of a face-centred cubic (fcc) core and extended arms of alternating fcc and hexagonal close-packed (hcp) nickel ...
Chaubey Nidhi - - 2013
We report the cloning, purification and cell proliferative activity of a novel recombinant GST tagged human granulocyte macrophage colony stimulating factor (GST-hGMCSF). The hGMCSF gene was PCR amplified from the cDNA of ACHN renal carcinoma cells and was cloned into the bacterial expression vector. The GST-hGMCSF was purified to homogeneity ...
Bernink Jochem H - - 2013
Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets T(H)2, T(H)17 and T(H)22. Here we describe a distinct ILC subset similar to T(H)1 cells, which we call ...
van Harssel J J T - - 2013
Epilepsy and mental retardation limited to females (EFMR), caused by PCDH19 mutations, has a variable clinical expression that needs further exploration. Onset of epilepsy may be provoked by fever and can resemble Dravet syndrome. Furthermore, transmitting males have no seizures, but are reported to have rigid personalities suggesting possible autism ...
Vallot Céline - - 2013
X-chromosome inactivation (XCI) in mammals relies on XIST, a long noncoding transcript that coats and silences the X chromosome in cis. Here we report the discovery of a long noncoding RNA, XACT, that is expressed from and coats the active X chromosome specifically in human pluripotent cells. In the absence ...
Murugesan A G - - 2013
The effect of integrated textile mill effluent on the haematological characteristic of the fish Heteropneustes fossilis was studied. LC(50) values were found to be 34 %-38 % on 96-24 h duration. Four sub-lethal concentrations were selected for this study. Exposure to effluent caused an increase in large lymphocytes, monocytes, neutrophils and ...
Hoch Matthias - - 2013
PURPOSE: To characterise further the previously observed cytochrome P450 3A4 (CYP3A4) interaction of the dual orexin receptor antagonist almorexant. METHODS: Pharmacokinetic interactions were investigated (n = 14 healthy male subjects in two treatment groups) between almorexant at steady-state when administered either concomitantly or 2 h after administration of single doses of simvastatin (40 mg) ...
Merritt Lucy - - 2013
Resting metabolic rates can vary greatly between individuals of the same species. These differences are generally repeatable and show moderate-to-high heritability, suggesting that they could be a target for natural selection. The present study therefore aimed to determine if inter-individual differences in resting metabolic rates (RMR) in garden skinks Lampropholis ...
Zhang De-Wen - - 2013
In this study, a simple miniaturized microliter electrochemical device was constructed using a disposable micropipette tip and a reproducible carbon fiber ultramicroelectrode. The novel electrochemical device set the electrochemical reaction in a micropipette tip containing an ultramicroelectrode. We investigated the feasibility of the designed electrochemical device by cyclic voltammetric measurements ...
Arora S - - 2013
Developmental processes require a precise spatio-temporal regulation of gene expression wherein a diverse set of transcription factors control the signalling pathways. MicroRNAs (miRNAs), a class of small non-coding RNA molecules have recently drawn attention for their prominent role in development and disease. These tiny sequences are essential for regulation of ...
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