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Results 651 - 700 of 4815
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Bugalho Paulo - - 2013
Our objectives were to characterize gait dysfunction in Parkinson's disease (PD) and normal pressure hydrocephalus (NPH) patients, in a comparative analysis. We used a walking test to determine gait velocity (GV), stride length (SL), stride cadence and the presence of frontal (FG) and sub-cortical hypokinetic gait (SHG) features. Equilibrium was ...
Okada Masaho - - 2013
Definitive endovascular techniques have been developed for pacemaker lead extraction; however, a few patients require immediate secondary open heart surgery because of incomplete transvenous lead extraction. This study examined the safety, effectiveness, and long-term outcome of the removal of cardiovascular implantable electronic device (CIED) via median sternotomy under cardiopulmonary bypass. ...
Cheng Myra - - 2013
The aims of this study are twofold: (i) to pay tribute to Hartmann Stahelin for his scientific research on cyclosporin A; and (ii) to consider possible lessons for future pharmacological innovation by revisiting Stahelin's personal struggles to obtain fair recognition for his contribution to transplantation medicine.
Liu Yun - - 2013
Epigenetic mechanisms integrate genetic and environmental causes of disease, but comprehensive genome-wide analyses of epigenetic modifications have not yet demonstrated robust association with common diseases. Using Illumina HumanMethylation450 arrays on 354 anti-citrullinated protein antibody-associated rheumatoid arthritis cases and 337 controls, we identified two clusters within the major histocompatibility complex (MHC) ...
Anastasakis Anastasios - - 2013
A 69-year-old male patient presented to our department with a 3-month history of nyctalopia. Reviewing of his general health revealed a history of gastrointestinal tumor treated with a modified WHIPPLE operation. Ocular findings at presentation included mild xerophthalmic features and nonspecific pigmentary retinal changes. A standard full-field electroretinogram (ERG) was ...
Rainey Helen - - 2013
BACKGROUND: Poor recognition of and response to acute illness in hospitalized patients continues to cause significant harm despite the implementation of safety strategies such as early warning scores. Patients and their relatives may be able to contribute to their own safety by speaking up about changes in condition, but little ...
Zaki Kamarul - - 2013
The introduction of targeted therapies, specifically those that target the VEGF receptor (VEGFR), PDGF receptor (PDGFR) and the mTOR pathways, has significantly changed the approach to patients with unresectable renal cell cancer (RCC). However, drug resistance develops through bypassing of targeted pathways. Regorafenib (BAY 73-4506) is a novel bi-aryl urea ...
Yin L - - 2013
AIMS: Increase the L-isoleucine production in Corynebacterium glutamicum by overexpressing the global regulator Lrp and the two-component export system BrnFE. METHODS AND RESULTS: The brnFE operon and the lrp gene were cloned into the shuttle vector pDXW-8 individually or in combination. The constructed plasmids were transformed into an L-isoleucine producing ...
Sheele Johnathan M - - 2013
OBJECTIVES: To determine whether the detection of human IgG bound to Schistosoma haematobium eggs from filtered urine could be used as a rapid diagnostic test (RDT-Sh). METHODS: We filtered 160 urine samples from children in the Kwale District of Kenya to isolate S. haematobium eggs and used anti-human IgG antibody conjugated ...
Kunisada Makoto - - 2013
UVA is currently thought to be carcinogenic because, similar to UVB, it induces the formation of cyclobutane pyrimidine dimers (CPDs). Various drugs have been reported to cause photosensitive drug eruptions as an adverse effect. Although the precise mechanism of photosensitive drug eruption remains to be elucidated, it is generally accepted ...
Ouyang Wei - - 2013
Dynamics of livestock and poultry manure nutrient was analyzed at a provincial scale from 2002 to 2008. The nutrient capacity of 18 kinds of croplands and grasslands to assimilate nutrients was assessed in the same temporal-spatial scale. Manure nitrogen (N) had increased from 5.111 to 6.228 million tons (MT), while ...
Jakobs S - - 2013
The aim of this article is the detailed consideration of the scientific opinion on the substantiation of health claims related to lutein and maintenance of vision, which was published by European Food Safety Authority (EFSA). The findings regarding the efficacy of lutein are important for the legal product classification. Thus, ...
Moosavi Seyyed Reza SR Department of Neurosurgery, Kerman University of Medical Sciences, Kerman, - - 2013
Immunological factors are important in pathogenesis of various malignancies, including neural cancers. The CXC chemokine CXCL12 is involved in the immune responses. Therefore, the aim of the present study was to investigate the association between tumor tissue and circulating concentrations of CXCL12 as well as its genetic variation at position ...
Sun Min - - 2013
Uniformly cut In(2) O(3) truncated octahedrons are fabricated on a large scale by a simple chemical vapor deposition (CVD) technique. This theoretical analysis predicts that the emergence of {100} facets on the In(2) O(3) truncated octahedrons enhances oxygen evolution significantly in photocatalysis and experimental photoelectrochemical measurements are consistent.
Almeida Lígia Moreira - - 2013
Pregnancy is a period of increased vulnerability for migrant women, and access to healthcare, use and quality of care provided during this period are important aspects to characterize the support provided to this population. A systematic review of the scientific literature contained in the MEDLINE and SCOPUS databases was carried ...
Beaton C - - 2013
AIM: Lymph node (LN) metastases are present in up to 17% of early colorectal cancers (pT1). Identification of associated histopathological factors would enable counseling of patients regarding this risk. METHOD: Pubmed and Embase were employed utilising the terms 'early colorectal cancer', 'lymph node metastasis', 'submucosal invasion', 'lymphovascular invasion', 'tumour budding' ...
Lahutte-Auboin Marion - - 2013
WHO II low grade glioma evolves inevitably to anaplastic transformation. Magnetic resonance imaging is a good non-invasive way to watch it, by hemodynamic and metabolic modifications, thanks to multinuclear spectroscopy (1)H/(31)P. In this work we study a multi-scale minimal model of hemodynamics and metabolism applied to the study of gliomas. ...
Rana Jyoti - - 2013
Successful infection with chikungunya virus (CHIKV) depends largely on the ability of this virus to manipulate cellular processes in its favour through specific interactions with several host factors. The knowledge of virus-host interactions is of particular value for understanding the interface through which therapeutic strategies could be applied. In the ...
Schmid Brigitte - - 2013
Evidence from animal research has demonstrated the effect of early maternal care on the offspring's endocrine and behavioral stress response in adulthood. The present prospective study investigates, in humans, the long-term impact of maternal responsiveness and stimulation during early mother-child interaction on adrenocorticotropic hormone (ACTH) and cortisol response to a ...
Kuepper R - - 2013
OBJECTIVE: Although cannabis use among individuals with psychotic disorder is considerable, little is known about patterns of use and factors contributing to continuation of use. Therefore, we investigated craving in relation to cannabis use in patients with psychotic disorder and healthy controls. METHOD: The study included 58 patients with non-affective ...
DeKosky Brandon J BJ Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, - - 2013
Each B-cell receptor consists of a pair of heavy and light chains. High-throughput sequencing can identify large numbers of heavy- and light-chain variable regions (V(H) and V(L)) in a given B-cell repertoire, but information about endogenous pairing of heavy and light chains is lost after bulk lysis of B-cell populations. ...
Jo Youn Yi - - 2013
PURPOSE: The authors conducted a prospective, randomized, double-blind study to evaluate the anti-shivering efficacy of palonosetron for patients after gynecological laparoscopy under total intravenous propofol-remifentanil anesthesia. METHODS: Sixty female patients were randomly assigned to one of two groups and administered palonosetron 0.075 mg (palonosetron group, n = 30) or the same volume of ...
Pugh Trevor J TJ The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, - - 2013
Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. To determine the spectrum of somatic mutation in high-risk neuroblastoma, we studied 240 affected individuals (cases) using a combination of whole-exome, genome and transcriptome sequencing ...
Cavazzoni Emanuel - - 2013
Thank you for the opportunity you gave us to answer the stimulating questions posed by Mr Hotouras and his colleagues, and for the interest shown in our study. The patients described in the article were referred to our emergency proctology unit from their General Practitioner (outpatients) or from the hospital ...
Tang Weiming - - 2013
Unprotected anal intercourse (UAI) is a well-documented risk factor for acquiring HIV, but not well-studied in China. We studied demographic and behavioral correlates for UAI among men who have sex with men (MSM) in a respondent-driven-sampling (RDS) survey in Nanjing, China. Four hundred and thirty MSM (including ten seeds) participated ...
Lim Chi Kim - - 2013
Reactive dyes account for one of the major sources of dye wastes in textile effluent. In this study, decolorization of the monoazo dye, Acid Orange 7 (AO7) by the Enterococcus faecalis strain ZL that isolated from a palm oil mill effluent treatment plant has been investigated. Decolorization efficiency of azo ...
Cortez M Lorena - - 2013
This work describes the synergistic combination of ionic self-assembly and recognition-directed assembly with the aim of creating highly functional bioelectrochemical interfaces compatible with the supramolecular design of a wide variety of biosensing platforms. A recently synthesized glycopolyelectrolyte constituted of polyallylamine bearing redox-active osmium complexes and glycosidic residues (lactose) is used ...
Sigurdsson K - - 2013
K. Sigurdsson Is a liquid-based cytology more sensitive than a conventional Pap smear? Background:  The comparative sensitivity of liquid-based cytology (LBC) test and conventional Papanicolaou (Pap) smears is controversial. Material and methods:  This study analyses the distribution of cytology, histology, colposcopy and large loop excision of the transformation zone among ...
Heithersay Ao Geoffrey S - - 2013
BACKGROUND: The understanding and management of transverse intra-alveolar root fractures has evolved to its current high level of sophistication and clinical success from foundations laid down by histological studies as early as the mid-nineteenth century. SIGNIFICANCE: The aim of the review was to highlight those earlier histological reports and studies ...
Hoch Matthias - - 2013
PURPOSE: To characterise further the previously observed cytochrome P450 3A4 (CYP3A4) interaction of the dual orexin receptor antagonist almorexant. METHODS: Pharmacokinetic interactions were investigated (n = 14 healthy male subjects in two treatment groups) between almorexant at steady-state when administered either concomitantly or 2 h after administration of single doses of simvastatin (40 mg) ...
Merritt Lucy - - 2013
Resting metabolic rates can vary greatly between individuals of the same species. These differences are generally repeatable and show moderate-to-high heritability, suggesting that they could be a target for natural selection. The present study therefore aimed to determine if inter-individual differences in resting metabolic rates (RMR) in garden skinks Lampropholis ...
Zhang De-Wen - - 2013
In this study, a simple miniaturized microliter electrochemical device was constructed using a disposable micropipette tip and a reproducible carbon fiber ultramicroelectrode. The novel electrochemical device set the electrochemical reaction in a micropipette tip containing an ultramicroelectrode. We investigated the feasibility of the designed electrochemical device by cyclic voltammetric measurements ...
Arora S - - 2013
Developmental processes require a precise spatio-temporal regulation of gene expression wherein a diverse set of transcription factors control the signalling pathways. MicroRNAs (miRNAs), a class of small non-coding RNA molecules have recently drawn attention for their prominent role in development and disease. These tiny sequences are essential for regulation of ...
Hu Hongbo H Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Box 902, Houston, Texas 77030, - - 2013
The non-canonical NF-κB pathway forms a major arm of NF-κB signalling that mediates important biological functions, including lymphoid organogenesis, B-lymphocyte function, and cell growth and survival. Activation of the non-canonical NF-κB pathway involves degradation of an inhibitory protein, TNF receptor-associated factor 3 (TRAF3), but how this signalling event is controlled ...
Popli Subhash - - 2013
Hypernatremia may result from inadequate water intake, excessive water loss or a combination of the two. Osmotic diuresis leads to losses of both solute and water. The relationship between solute and water losses determines the resulting changes in serum osmolality and sodium concentration. Total solute loss is routinely higher than ...
Broderick Adam H - - 2013
We report an approach to preventing bacterial biofilm formation that is based on the surface-mediated release of 5,6-dimethyl-2-aminobenzimidazole (DMABI), a potent and non-bactericidal small-molecule inhibitor of bacterial biofilm growth. Our results demonstrate that DMABI can be encapsulated in thin films of a model biocompatible polymer [poly(lactide-co-glycolide), PLG] and be released ...
Ren Xiao-Ling - - 2013
Potassium transporters and channels play crucial roles in K(+) uptake and translocation in plant cells, which are essential for plant growth and development. AKT1 has been reported as an important K(+) channel in Arabidopsis roots involved in K(+) uptake. It is known that AKT1 is activated by a protein kinase ...
Couey Jonathan J - - 2013
Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and ...
Georgieva Elka R - - 2013
Sodium and aspartate symporter from Pyrococcus horikoshii, Glt(Ph), is a homolog of the mammalian glutamate transporters, homotrimeric integral membrane proteins that control neurotransmitter levels in brain synapses. These transporters function by alternating between outward-facing and inward-facing states, in which the substrate binding site is oriented toward the extracellular space and ...
Muris Peter - - 2013
This cross-sectional study examined the Dark Triad personality traits and their correlates in non-clinical youths aged 12-18 years (N = 117). Child- and parent-report data were obtained on Machiavellianism, narcissism, and psychopathy as well as on Big Five personality factors and symptoms of aggression and delinquency. Results indicated that especially Machiavellianism and psychopathy ...
Taguchi Tetsuya - - 2013
The combination of capecitabine and paclitaxel (XP) has demonstrated synergistic antitumor activity in preclinical models. The purpose of this phase II study was to evaluate the efficacy and safety of a monthly XP regimen in patients with metastatic breast cancer (MBC). Eligible patients had received one or fewer prior chemotherapy ...
George Saby - - 2013
Castration resistant prostate cancer (CRPC) treatment has been revolutionized over the past few years by the approval of novel therapies including cabazitaxel, sipuleucel-T, abiraterone and enzalutamide. Though androgen deprivation and chemotherapy remain the main therapeutic approaches for this disease, a series of targeted agents is also in development for the ...
Bandarenka Aliaksandr S - - 2013
Acquisition of localized electrochemical impedance spectra as a function of spatial coordinates combined with novel approaches of data analysis brings a key for visualization of two-dimensional distributions of important parameters describing solid / liquid interfaces. They include the capacitance of the electric double layer, the resistance of the interfacial charge ...
von Bohlen Und Halbach Oliver - - 2013
A major interest in the analysis of animal models of psychiatric diseases is their underlying cellular pathology and to gain information regarding whether pharmacological treatments, genetic differences or an altered environment exert an impact upon the brain morphology or on the morphology or activity of single neurones. In this review, ...
Yeates Alexander - - 2013
BACKGROUND: This study aims to determine whether tricuspid regurgitation (TR) ≥ 2+ requires attention during mitral valve surgery. METHODS: From April 1999 to 2009, 161 patients undergoing primary, isolated mitral valve procedures were assessed. Preoperative moderate TR (≥2+) was present in 56 of 161 patients and tricuspid valve repair (TVR: ...
Teodorowicz MaƂgorzata - - 2013
PURPOSE: The purpose of this study was to determine the influence of Maillard reaction (MR, glycation) on biochemical and biological properties of the major peanut allergen Ara h 1. METHODS: Three different time/temperature conditions of treatment were applied (37, 60, and 145 °C). The extent of MR was assessed by SDS-PAGE, ...
Hamdalla Mai A - - 2013
The structural identification of unknown biochemical compounds in complex biofluids continues to be a major challenge in metabolomics research. Using LC/MS there are currently two major options for solving this problem: searching small biochemical databases, which often do not contain the unknown of interest, or searching large chemical databases which ...
Cabahug Leah Mae - - 2013
This supplement was not sponsored by outside commercial interests. It was funded entirely by the publisher.
Venkatanarayanan Anita - - 2013
Ovarian cancer cells, SKOV3, have been immobilized onto platinum microelectrodes using anti-EPCAM capture antibodies and detected with high sensitivity using electrochemical impedance. The change in impedance following cell capture depends strongly on the supporting electrolyte concentration. By controlling the concentration of Dulbecco's phosphate buffered saline (DPBS) electrolyte, the double layer ...
Li Li - - 2013
OBJECTIVE: Apoptosis of alveolar epithelial cells (AECs) plays a key role in acute lung injury (ALI). Understanding the underlying mechanism is conducive to the treatment of ALI. The goal of this study was to determine the possible involvement of nuclear factor-κB (NF-κB)/p65 and Bax/Bcl-2 in tumor necrosis factor-α (TNF-α)-induced apoptosis ...
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