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Results 551 - 600 of 4798
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Bonnevie Tora - - 2013
To determine how hippocampal backprojections influence spatially periodic firing in grid cells, we recorded neural activity in the medial entorhinal cortex (MEC) of rats after temporary inactivation of the hippocampus. We report two major changes in entorhinal grid cells. First, hippocampal inactivation gradually and selectively extinguished the grid pattern. Second, ...
Chang In Ae - - 2013
Following spinal cord injury (SCI), glial cells are recognized as major environmental factors hampering axon's regenerative responses. However, recent studies suggested that, in certain circumstances, reactive astrocytes may have a permissive role for axonal regeneration and functional recovery. Here, we report that Cdc2 activation in astrocytes is positively linked to ...
Kiyota Hidemi - - 2013
BACKGROUND: A phase I dose-escalation study was performed to investigate the safety and pharmacokinetics of the combination of S-1 and gefitinib in patients with pulmonary adenocarcinoma who had failed previous chemotherapy. METHODS: Patients received gefitinib at a fixed daily oral dose of 250 mg, and S-1 was administered on days 1-14 ...
Kolotuev Irina - - 2013
The mechanisms regulating the extension of small unicellular tubes remain poorly defined. Here we identify several steps in Caenorhabditis elegans excretory canal growth, and propose a model for lumen extension. Our results suggest that the basal and apical excretory membranes grow sequentially: the former extends first like an axon growth cone; ...
Chutipongtanate Somchai - - 2013
Our previous report showed that uropathogenic bacteria, e.g., Escherichia coli, are commonly found inside the nidus of calcium oxalate (CaOx) kidney stones and may play pivotal roles in stone genesis. The present study aimed to prove this new hypothesis by direct examining CaOx lithogenic activities of both Gram-negative and Gram-positive ...
Suyanı Elif - - 2013
The interaction between multiple myeloma (MM) cells and the bone marrow stroma constitutes the basis of myeloma pathogenesis and has led the way for the corresponding therapeutic strategies. The aim of this study is to evaluate tumor-associated macrophages (TAMs) which is an important element of bone marrow stroma and its ...
Hoffmann Céline - - 2013
Decisions on the fate of cells and their functions are dictated by the spatiotemporal dynamics of molecular signalling networks. However, techniques to examine the dynamics of these intracellular processes remain limited. Here, we show that magnetic nanoparticles conjugated with key regulatory proteins can artificially control, in time and space, the ...
Rassami Watcharawit - - 2013
Head lice infestation, a worldwide head infestation caused Pediculus humanus capitis De Geer, is an important public health problem in Thailand. Several chemical pediculicides have lost in efficacy due to increasing resistance of lice against insecticide. Therefore, non-toxic alternative products, such as natural products from plants, e.g. plant extract pediculicides, ...
Griksaitis Michael J - - 2013
AIMS: Sudden cardiac death (SCD) risk can be managed by implantable cardioverter defibrillators (ICD). Defibrillation shocks can be delivered via ICD generator and/or intracardiac or subcutaneous coil configurations. We present our single-centre use of childhood ICDs.METHODS AND RESULTS: Twenty-three patients had ICD implantation, with median age and weight of 12.96 ...
Tochio Takumi - - 2013
Background  Glucose transporter member 1 (GLUT-1) is one of the major facilitated glucose transporters and contributes to the promotion of keratinocyte proliferation in psoriasis and carcinogenic lesions. In this study, we postulate that GLUT-1 is involved in ultraviolet B (UVB)-induced epidermal hyperplasia. The purpose of this study is to investigate ...
Riedel-Heller S G - - 2013
This paper reviews the concepts, evidence and implications regarding mental health at the workplace. The theoretical background with the most common theories (e.g. effort-reward imbalance model and job-demand control model) are briefly reviewed and findings from systematic reviews and from a meta-analysis regarding psychosocial factors at the workplace and common ...
Basu Rajit K - - 2013
There is a growing appreciation for the role that acute kidney injury (AKI) plays in the propagation of critical illness. In children, AKI is not only an independent predictor of morbidity and mortality, but is also associated with especially negative outcomes when concurrent with acute lung injury (ALI). Experimental data ...
Groeschl Ryan T - - 2013
BACKGROUND: Surgical therapies for hepatocellular carcinoma (HCC) represent the potentially curative approaches and provide patients the greatest survival advantage. We sought to examine the outcomes of patients with HCC treated with surgical resection, transplantation, and local ablation. METHODS: The Surveillance, Epidemiology, and End Results database was queried for all patients ...
Vardakas K Z - - 2013
To summarize the published evidence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) bone and joint infections. PubMed and Scopus electronic databases were searched. The annual incidence of invasive CA-MRSA infections ranged from 1.6 to 29.7 cases per 100,000, depending on the location of the population studied; bone and joint infections accounted ...
Mitchell Paul J - - 2013
Fracture Liaison Services (FLS) have been demonstrated in many countries to provide an effective means to deliver secondary preventive care for patients presenting with fragility fractures. This review provides an update on journal articles, reports, guidelines and government policies, with relevance to FLS, which have been published during the period ...
Ryan Joseph P - - 2013
Victims of child abuse and neglect are at an increased risk of involvement with the juvenile justice and adult correctional systems. Yet, little is known about the continuation and trajectories of offending beyond initial contact with law enforcement. Neglect likely plays a critical role in continued offending as parental monitoring, ...
Wang Jianqiao - - 2013
Bisphenol A (BPA) was treated with hyper lignin-degrading fungus Phanerochaete sordida YK-624 under ligninolytic condition. After preculturing P. sordida YK-624 for 4 days, BPA (final concentration, 1 and 0.1 mM) was added to cultures. Both 1- and 0.1-mM BPA were effectively decreased within a 24-h treatment and two metabolites were detected. Two ...
Liu Bin - - 2013
This paper presents the results of wet precipitation chemistry from September 2009 to August 2010 at a high-altitude forest site in the southeastern Tibetan Plateau (TP). The alkaline wet precipitation, with pH ranging from 6.25 to 9.27, was attributed to the neutralization of dust in the atmosphere. Wet deposition levels ...
Krull Cornelius - - 2013
Chemical doping offers promise as a means of tailoring the electrical characteristics of organic molecular compounds. However, unlike for inorganic semiconductors used in electronics applications, controlling the influence of dopants in molecular complexes is complicated by the presence of multiple doping sites, electron acceptor levels, and intramolecular correlation effects. Here ...
Hadji P - - 2013
Compliance and persistence are often underestimated in breast cancer (BC) treatment. The aim of our study was to analyze the persistence with tamoxifen (TAM) and aromatase inhibitors (AI) in postmenopausal women with hormone-receptor-positive BC and to identify determinants of non-persistence. We used data of the Disease Analyzer database (IMS HEALTH, ...
Peng Chuantao - - 2013
The influence of a pre-fermentative freezing process on changes of aromatic characteristics and volatile compounds in Meili wines was studied to optimize freezing parameters and reveal the mathematical relationship between aromatic characteristics and volatile compounds. The wines obtained were characterized by sensory evaluation and stir bar sorptive extraction (SBSE) followed ...
Macrae Phoebe R - - 2013
Changes in morphometry of head and neck muscles have received little attention in research relative to limb muscles. While recent literature suggests that high-frequency ultrasound transducers can provide superior spatial resolution compared to that of magnetic resonance imaging (MRI), no studies have compared these imaging methods for investigating the submental ...
Evangeliou Nikolaos - - 2013
Particle-reactive radionuclide (234)Th and its ratios with the conservative (238)U were used to trace the marine processes occurring over short timescales in the bottom nepheloid layer (BNL) of seven stations in the Saronikos Gulf and the Elefsis Bay (Greece) during three seasons (summer 2008, autumn 2008 and winter 2009). Summer ...
Blank Wilson Amy - - 2013
This paper examines the role that substance use and serious mental illness play in criminal justice recidivism by examining the time to return to jail for a cohort of people admitted to jail in 2003 (N = 16,434). These analyses found that people with serious mental illness alone experienced the longest time ...
Nitzkorski James R - - 2013
BACKGROUND: Few studies have evaluated disparities of race and socioeconomic status (SES) with outcomes in patients with rectal cancer. We hypothesize that disparities exist in the treatment and outcomes among patients with rectal cancer. METHODS: Medical records of all patients with rectal cancer treated from 2000 to 2009 at an ...
Liu Xiaoqian - - 2013
In this article, polydopamine (Pdop) functionalized multi-walled carbon nanotubes (MWCNTs@Pdop) were firstly synthesized and employed as the template for the dispersion of Pt nanoparticles (NPs) to form Pt/MWCNTs@Pdop hybrid nanocomposite. The characterizations of the Pt/MWCNTs@Pdop were investigated by SEM, TEM, XRD and voltammetry. Based upon the Pt/MWCNTs@Pdop nanocomposite, a modified ...
Us Murat Faruk - - 2013
Dispersive liquid-liquid microextraction based on solidification of floating organic drop (DLLME-SFO) was for the first time combined with field-amplified sample injection (FASI) in CE to determine four β(2) -agonists (cimbuterol, clenbuterol, mabuterol and mapenterol) in bovine urine. Optimum BGE consisted of 20 mM borate buffer containing 0.1 mM SDS. Using ...
Naveen Kuttanda A - - 2013
Detection and pathotyping of Newcastle disease virus (NDV) is extremely important because the appearance of virulent virus has significant economic consequences. During 1981 to 1985, infections of racing and show pigeons with an avian paramyxovirus serotype-1 (APMV-1) hit worldwide, and a panzootic occurred due to a variant form of classical ...
Zhao Lei - - 2013
A new planar and centrally chiral bicyclic 1,2,4-triazolium salt has been synthesized from [2.2]paracyclophane and phenylglycinol. The N-heterocyclic carbene (NHC) copper(I) complex generated in situ by the reaction of the triazolium salt and Cu2O was an efficient catalyst for the asymmetric β-boration of acyclic enones, producing β-boryl ketones in high ...
Popli Subhash - - 2013
Hypernatremia may result from inadequate water intake, excessive water loss or a combination of the two. Osmotic diuresis leads to losses of both solute and water. The relationship between solute and water losses determines the resulting changes in serum osmolality and sodium concentration. Total solute loss is routinely higher than ...
Broderick Adam H - - 2013
We report an approach to preventing bacterial biofilm formation that is based on the surface-mediated release of 5,6-dimethyl-2-aminobenzimidazole (DMABI), a potent and non-bactericidal small-molecule inhibitor of bacterial biofilm growth. Our results demonstrate that DMABI can be encapsulated in thin films of a model biocompatible polymer [poly(lactide-co-glycolide), PLG] and be released ...
Ren Xiao-Ling - - 2013
Potassium transporters and channels play crucial roles in K(+) uptake and translocation in plant cells, which are essential for plant growth and development. AKT1 has been reported as an important K(+) channel in Arabidopsis roots involved in K(+) uptake. It is known that AKT1 is activated by a protein kinase ...
Couey Jonathan J - - 2013
Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and ...
Muris Peter - - 2013
This cross-sectional study examined the Dark Triad personality traits and their correlates in non-clinical youths aged 12-18 years (N = 117). Child- and parent-report data were obtained on Machiavellianism, narcissism, and psychopathy as well as on Big Five personality factors and symptoms of aggression and delinquency. Results indicated that especially Machiavellianism and psychopathy ...
George Saby - - 2013
Castration resistant prostate cancer (CRPC) treatment has been revolutionized over the past few years by the approval of novel therapies including cabazitaxel, sipuleucel-T, abiraterone and enzalutamide. Though androgen deprivation and chemotherapy remain the main therapeutic approaches for this disease, a series of targeted agents is also in development for the ...
Bandarenka Aliaksandr S - - 2013
Acquisition of localized electrochemical impedance spectra as a function of spatial coordinates combined with novel approaches of data analysis brings a key for visualization of two-dimensional distributions of important parameters describing solid / liquid interfaces. They include the capacitance of the electric double layer, the resistance of the interfacial charge ...
Yeates Alexander - - 2013
BACKGROUND: This study aims to determine whether tricuspid regurgitation (TR) ≥ 2+ requires attention during mitral valve surgery. METHODS: From April 1999 to 2009, 161 patients undergoing primary, isolated mitral valve procedures were assessed. Preoperative moderate TR (≥2+) was present in 56 of 161 patients and tricuspid valve repair (TVR: ...
Hamdalla Mai A - - 2013
The structural identification of unknown biochemical compounds in complex biofluids continues to be a major challenge in metabolomics research. Using LC/MS there are currently two major options for solving this problem: searching small biochemical databases, which often do not contain the unknown of interest, or searching large chemical databases which ...
Cabahug Leah Mae - - 2013
This supplement was not sponsored by outside commercial interests. It was funded entirely by the publisher.
Anastasakis Anastasios - - 2013
A 69-year-old male patient presented to our department with a 3-month history of nyctalopia. Reviewing of his general health revealed a history of gastrointestinal tumor treated with a modified WHIPPLE operation. Ocular findings at presentation included mild xerophthalmic features and nonspecific pigmentary retinal changes. A standard full-field electroretinogram (ERG) was ...
Miskin Marc Z - - 2013
Over 200 years after Coulomb's studies, a general connection between the mechanical response of a granular material and the constituents' shape remains unknown. The key difficulty in articulating this relationship is that shape is an inexhaustible parameter, making its systematic exploration infeasible. Here we show that the role of particle ...
Honka H - - 2013
AIMS/HYPOTHESIS: The role of the intestine in the pathogenesis of metabolic diseases is gaining much attention. We therefore sought to validate, using an animal model, the use of positron emission tomography (PET) in the estimation of intestinal glucose uptake (GU), and thereafter to test whether intestinal insulin-stimulated GU is altered ...
Gschwendtner A - - 2013
Stroke is one of the most widespread causes of mortality und disability worldwide. Around 80 % of strokes are ischemic and different forms of intracranial bleeding account for the remaining cases. Monogenic stroke disorders are rare but the diagnosis may lead to specific therapeutic consequences for the affected patients who are ...
Nahnsen Sven - - 2013
The analysis of peptides and proteins in complex biological systems has greatly improved over the last decade. State-of-the-art mass spectrometric instruments combined with adequate software tools allow for more and more comprehensive proteome analyses. Most proteome-wide studies focus on the analysis of unmodified proteins or look at selected modifications only. ...
Rabelo Sarita C - - 2013
Sugarcane bagasse was subjected to lime (calcium hydroxide) pretreatment and enzymatic hydrolysis for second-generation ethanol production. A central composite factorial design was performed to determine the best combination of pretreatment time, temperature, and lime loading, as well as to evaluate the influence of enzymatic loadings on hydrolysis conversion. The influence ...
Verma Harsha - - 2013
Porcine kobuvirus has been associated with piglet diarrhea in Asia and Europe, but there are no reports of its presence in the U.S. swine farms. We screened intestinal contents from 114 diarrheic pigs and fecal samples from 46 apparently healthy pigs to determine the presence of kobuvirus by reverse transcription-polymerase ...
de Klerk T A - - 2013
To determine whether primary trabeculectomies performed in a UK district general hospital, specifically without making use of mitomycin-C augmentation but with selective use of the low potency anti-metabolite 5-fluorouracil, produce an acceptable long-term intraocular pressure (IOP)-lowering effect for an unselected patient group. Retrospective analysis of the outcomes of all the ...
Nam Kwang-Mo - - 2013
Here we report development of the galvanostatic Fourier transform electrochemical impedance spectroscopy (FTEIS), which monitors impedance of electrochemical reactions activated by current steps. We first derive relevant relations for potential change upon application of a step current, obtain impedances theoretically from the relations by simulation, and verify them with experimental ...
Pifl Christian - - 2013
We recently found severe noradrenaline deficits throughout the thalamus of patients with Parkinson's disease (Pifl et al., 2012). Since this noradrenaline loss was especially severe in nuclei of the motor thalamus normally transmitting basal ganglia motor output to the cortex, we hypothesized that this noradrenaline loss aggravates the motor disorder ...
Lin Qing-Yuan - - 2013
The mechanical properties of ultra-thin membranes have attracted considerable attention recently. Nanoindentation based on atomic force microscope is commonly employed to study the mechanical properties. We find that the data processing procedures in previous studies are nice approximations, but they are difficult to illustrate the mechanical properties precisely. Accordingly, we ...
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