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Given J E JE Institute of Nursing Research, University of Ulster, Coleraine, UK. - - 2013
To synthesize evidence relating to comparisons between patient-generated blood glucose records and meter memory in diabetes and to identify any predictors of agreement. A systematic literature search was performed to identify articles comparing meter and diary records in those unaware of this assessment. Eleven observational studies, covering patients with Type ...
Gartland Matthew G MG Vanderbilt University School of Medicine, Nashville, Tennessee, - - 2013
To evaluate the effectiveness of maternal combination antiretroviral prophylaxis for prevention of mother-to-child transmission of HIV (PMTCT) in a program setting. Prospective cohort study. Nine primary care clinics in rural Zambia. Two hundred and eighty-four HIV-infected pregnant women at at least 28 weeks gestation initiating PMTCT services between April 2009 ...
Grebely Jason J The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia. - - 2013
Systemic levels of interferon-gamma-inducible protein-10 (IP-10) are predictive of treatment-induced clearance in chronic hepatitis C virus (HCV). In the present study, factors associated with plasma IP-10 levels at the time of acute HCV detection and the association between IP-10 levels and spontaneous clearance were assessed in three cohorts of acute ...
Ceylan Bahadir - - 2013
We aimed to determine whether mean platelet volume (MPV) is one of the variables that determine the severity of liver fibrosis and inflammation. Patients with chronic hepatitis B virus (HBV) infection were divided into two groups: patients with fibrosis scores of 0-3 and 4-6 and patients with histologic activity index ...
Stewart Kerry-Ann A KA Stanford University School of Medicine, Stanford, CA, - - 2013
To use a nationwide household survey tool to provide an estimate of injury prevalence, mechanisms of traumatic injuries, and number of injury-related deaths in a low-income country. A randomized, cross-sectional nationwide survey using the Surgeons OverSeas Assessment of Surgical Need tool was conducted in 2012. Sierra Leone, Africa. Three thousand ...
Jones Edward L EL Department of Surgery, University of Colorado Denver, Aurora, CO 80045, - - 2013
To analyze the predictors and patterns of recurrence of melanoma in patients with a negative sentinel lymph node biopsy result. Retrospective chart review of a prospectively created database of patients with cutaneous melanoma. SETTING Tertiary university hospital. A total of 515 patients with melanoma underwent a sentinel lymph node biopsy ...
Chittaranjan Andrade A Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India. - - 2013
Depression and heart disease are commonly comorbid. Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression. In March 2011, we carried out a 15-year search of PubMed for preclinical and clinical publications related to SSRIs and ischemic heart disease (IHD) or congestive heart failure (CHF). We identify and ...
Deyo Richard A RA Department of Family Medicine, The Dartmouth Institute for Health Policy and Clinical Practice, USA. - - 2013
Retrospective cohort analysis of Medicare claims for 2006-2009. To examine whether interspinous distraction procedures are used selectively in patients with more advanced age or comorbidity, and whether they are associated with fewer complications, lower costs, and less revision surgery than laminectomy or fusion surgery. A manufacturer-sponsored randomized trial suggested an ...
Davies M J MJ Department of Cardiovascular Sciences, University of Leicester, UK. - - 2013
To identify real-world factors affecting adherence to insulin therapy in patients with Type 1 or Type 2 diabetes mellitus. A literature search was conducted in PubMed and EMBASE in November 2011 to identify studies reporting factors associated with adherence/non-adherence to insulin therapy in adults with Type 1 or Type 2 ...
Liang Frank F Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Stockholm, - - 2013
To study whether in-vivo recruitment of dendritic cells in response to antigen administration in the skin is altered during HIV-1 infection. Skin punch biopsies were collected from HIV-1-positive as well as seronegative individuals at 48 h after intradermal injection of inactivated antigens of mumps virus, Candida albicans, or purified protein ...
Dingsdale Hayley - - 2013
We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER-PM junctions formed near the leading edge of migrating cells (usually within 0.5 μm of polymerized actin and ...
Galanaud Jean-Philippe - - 2013
Post-thrombotic syndrome (PTS) refers to chronic manifestations of venous insufficiency following a deep-vein thrombosis (DVT). It is a frequent, chronic, burdensome and costly disease for which therapeutic options are limited. Above all, the optimal management of PTS consists of preventing its occurrence: first, by preventing DVT, and second, by preventing ...
Weiser Raphaella E - - 2013
Hemorrhagic Transformation (HT) has been well recognized as a common cause of hemorrhage in ischemic stroke patients. Though this complication may occur independently, it has been particularly dreaded in the post rTPA patient and thus has been the focus for analysis of multiple thrombolytic trials. This review examines the effect ...
Ehrmann Stephan S Service de Réanimation Médicale Polyvalente, CHRU de Tours, Tours, France. - - 2013
To assess whether the use of iodinated contrast medium increases the incidence of acute kidney injury in ICU patients, compared with patients not receiving iodinated contrast medium. Prospective observational matched cohort study. Two ICUs in two tertiary teaching hospitals. A total of 380 adults were included (20% more than once), ...
Wolf Joel A JA University of Pittsburgh, Pittsburgh, Pennsylvania 15213, - - 2013
To measure the performance of smartphone applications that evaluate photographs of skin lesions and provide the user with feedback about the likelihood of malignancy. Case-control diagnostic accuracy study. Academic dermatology department. PARTICIPANTS AND MATERIALS: Digital clinical images of pigmented cutaneous lesions (60 melanoma and 128 benign control lesions) with a ...
Arzberger Edith E Department of Dermatology, Medical University of Graz, Graz, - - 2013
Zoon plasma cell balanitis is a benign inflammatory disease of genital skin. It may be difficult to clinically distinguish between balanitis and carcinoma in situ (CIS); thus, a biopsy may be needed to exclude malignant disease. Reflectance confocal microscopy (RCM) is an in vivo imaging method to get morphologic information ...
Jambusaria-Pahlajani Anokhi A Department of Dermatology, Mayo Clinic Florida, Jacksonville, - - 2013
This study proposes an alternative tumor staging system for cutaneous squamous cell carcinoma (CSCC) that more precisely defines the small subset of tumors with a high risk of metastasis and death. To identify risk factors for poor outcomes in CSCC and evaluate the 2010 American Joint Committee on Cancer (AJCC) ...
Jaimes Natalia N Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10022, - - 2013
To describe and analyze the clinical and dermoscopic characteristics of desmoplastic melanoma (DM) as a function of pathologic subtype and phenotypic traits. Retrospective case series. Eight high-risk dermatology clinics. Patients with DM confirmed by histopathologic analysis whose records included a high-quality dermoscopic image. Clinical, dermoscopic, and histopathologic features of DM. ...
Zabielinski Marilyn M Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, - - 2013
To determine whether the relative proportions of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S aureus (MSSA) were changing or stable in an outpatient dermatology clinic and to examine the antibiotic susceptibility profiles of S aureus isolates. Retrospective observational data were collected from skin culture isolates annually between January 1, 2005, ...
Chang Chih-Hao CH Department of Electrical Engineering, National Chiao Tung University, Hsinchu, - - 2013
Remarkable changes in cardiorespiratory interactions are frequently experienced by Chan meditation practitioners following years of practice. This study compares the results of our study on cardiorespiratory interactions for novice (control group) and experienced (experimental group) Chan meditation practitioners. The effectual co-action between the cardiac and respiratory systems was evaluated by ...
Hettema John M JM Departments of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA 23298-0126, - - 2013
Quantitative trait loci identified in animal models provide potential candidate susceptibility loci for human disorders. In this study, we investigated whether internalizing disorders (anxiety disorders, major depression, and neuroticism) were associated with a region on human chromosome 1 syntenic with a quantitative trait locus for rodent emotionality. We genotyped 31 ...
Hommel Kevin A KA Division of Behavioral Medicine and Clinical Psychology, Center for the Promotion of Treatment Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, MLC 7039, Cincinnati, OH 45229-3039, USA. - - 2013
To evaluate an individually tailored multicomponent nonadherence treatment protocol using a telehealth delivery approach in adolescents with inflammatory bowel disease. Nine participants, age 13.71±1.35 years, completed a brief treatment online through Skype. Medication nonadherence, severity of disease, and feasibility/acceptability data were obtained. Adherence increased markedly from 62% at baseline to ...
McLoughlin Fionn - - 2013
PA (phosphatidic acid) is a lipid second messenger involved in an array of processes occurring during a plant's life cycle. These include development, metabolism, and both biotic and abiotic stress responses. PA levels increase in response to salt, but little is known about its function in the earliest responses to ...
Kras Jeffrey V JV Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6392, - - 2013
This study used retrograde neuronal tracing and immunohistochemistry to identify neurons innervating the C6-C7 facet joint and those expressing calcitonin gene-related peptide (CGRP) in the dorsal root ganglion (DRG) of rats after painful cervical facet joint injury. The objective of this study was to characterize the innervation of the C6-C7 ...
Shah Chirag M - - 2013
Scapholunate advanced collapse (SLAC) and scaphoid nonunion advanced collapse (SNAC) are the two most common patterns of posttraumatic wrist arthritis. This review discusses the etiology and clinical evaluation, as well as up-to-date treatment options, for both of these conditions. Classic as well as newer innovative techniques are discussed with clinical ...
Ellsworth Katarzyna A - - 2013
FKBP51 (51 kDa immunophilin) acts as a modulator of the glucocorticoid receptor and a negative regulator of the Akt pathway. Genetic variation in FKBP5 plays a role in antidepressant response. The aim of this study was to comprehensively assess the role of genetic variation in FKBP5, identified by both Sanger ...
Bekeredjian R - - 2013
Aortic valve stenosis is the most prevalent, clinically significant valvular disorder in adult patients. Surgical valve replacement is the standard therapy for patients with symptomatic and severe aortic stenosis; however, many patients are suboptimal candidates for surgery due to age and co-morbidities. The development of transcatheter aortic valve implantation (TAVI) ...
Hodson Leanne L Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK. - - 2013
The fatty acid, palmitoleate (16:1 nā€Š-ā€Š7), has received a lot of attention in recent years for being 'lipokine' and for the first time, we review the evidence to determine if there is something special about palmitoleate in humans. Despite dietary intakes being low (<4% of total energy) palmitoleate is the ...
MacCabe James H JH Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, England. - - 2013
Clear evidence from many prospective, population-based studies indicates that patients who develop psychosis in adulthood experienced various cognitive deficits during childhood and adolescence. However, it is unclear whether these deficits become more severe during adolescence. To assess the influence of cognitive developmental trajectories in adolescence and young adulthood on the ...
Fitzsimmons Jennifer J Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. - - 2013
We review diffusion tensor imaging (DTI) studies that investigate white matter abnormalities in patients with chronic schizophrenia, first episode schizophrenia, and those who are at genetic risk for developing schizophrenia. Additionally, we include studies that combine DTI and functional MRI (fMRI) to investigate brain connectivity abnormalities. Schizophrenia is a complex ...
Guha Saurav S Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, New York 11004, - - 2013
Large genomic copy number variations have been implicated as strong risk factors for schizophrenia. However, the rarity of these events has created challenges for the identification of further pathogenic loci, and extremely large samples are required to provide convincing replication. To detect novel copy number variations that increase the susceptibility ...
Akubuiro A A Department of Neuroscience, University of Iowa, Iowa City, IA, - - 2013
ADAR2 transgenic mice misexpressing the RNA editing enzyme ADAR2 (Adenosine Deaminase that act on RNA) show characteristics of overeating and experience adult onset obesity. Behavioral patterns and brain changes related to a possible addictive overeating in these transgenic mice were explored as transgenic mice display chronic hyperphagia. ADAR2 transgenic mice ...
Matsubara Shigeki S Departments of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Japan. - - 2013
For cesarean hysterectomy with placenta previa accreta, "universally achievable" measures are required. We propose eight measures: (i) placement of intra-iliac arterial occlusion balloon catheters; (ii) placement of ureter stents; (iii) "holding the cervix" to identify the site to be transected; (iv) uterine fundal incision; (v) avoidance of uterotonics; (vi) "M ...
Liu Shu S Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, United - - 2013
A major challenge in drug discovery is to develop and improve methods for targeting protein-protein interactions. Further exemplification of the REPLACE (REplacement with Partial Ligand Alternatives through Computational Enrichment) strategy for generating inhibitors of protein-protein interactions demonstrated that it can be used to optimize fragment alternatives of key determinants, to ...
Vamos Mitchell M Program in Apoptosis and Cell Death and NCI Designated Cancer Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, - - 2013
A series of novel, potent antagonists of the inhibitor of apoptosis proteins (IAPs) were synthesized in a highly convergent and rapid fashion (≤6 steps) using the Ugi four-component reaction as the key step, thus enabling rapid optimization of binding potency. These IAP antagonists compete with caspases 3, 7, and 9 ...
Passarelli Melissa K MK Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States. - - 2013
Neurons isolated from Aplysia californica , an organism with a well-defined neural network, were imaged with secondary ion mass spectrometry, C(60)-SIMS. A major lipid component of the neuronal membrane was identified as 1-hexadecyl-2-octadecenoyl-sn-glycero-3-phosphocholine [PC(16:0e/18:1)] using tandem mass spectrometry (MS/MS). The assignment was made directly off the sample surface using a ...
Young Carissa L CL Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, - - 2013
An elaborate quality control system regulates endoplasmic reticulum (ER) homeostasis by ensuring the fidelity of protein synthesis and maturation. In budding yeast, genomic analyses and high-throughput proteomic studies have identified ER resident proteins that restore homeostasis following local perturbations. Yet, how these folding factors modulate stress has been largely unexplored. ...
Dort Sandra Van - - 2013
Abstract The lead article by Wylie, McAllister, Davidson, and Marshall (2013) puts forward pertinent issues facing the speech-language pathology profession raised by the World Report on Disability. This paper continues the discussion by reporting on a capacity building action research study on the development, implementation, and evaluation of a new ...
Else Paul L - - 2013
Lactation is a process associated with mammals, yet a number of birds feed their newly hatched young on secretions analogous to the milk of mammals. These secretions are produced from various sections (crop organ, oesophageal lining and proventriculus) of the upper digestive tract and possess similar levels of fat and ...
Burry Lisa - - 2013
ABSTRACT: Our objectives were to determine the incidence of critical illness-related corticosteroid insufficiency (CIRCI) in patients with septic shock using a 1 μg corticotropin (ACTH) test and to describe their clinical outcomes. We retrospectively identified 219 consecutive patients with septic shock assessed for CIRCI with a 1 μg ACTH test. ...
Baandrup Louise - - 2013
Approximately 90% of genital warts (GWs) are caused by human papillomavirus (HPV) types 6 and 11. Denmark has provided the quadrivalent HPV vaccine to all 12-year-old girls since 2009 and catch-up vaccination to girls up to 15 years since 2008, with up to 80% to 85% vaccine coverage. We determined ...
van Griethuijsen Linnea I - - 2013
Aimed movements require that an animal accurately locates the target and correctly reaches that location. One such behavior is the defensive strike seen in Manduca sexta larva. These caterpillars respond to noxious mechanical stimuli applied to their abdomen with a strike of the mandibles towards the location of the stimulus. ...
Brydges Ryan - - 2013
Context  Simulation-based medical education allows trainees to engage in self-regulated learning (SRL), yet research aimed at elucidating the mechanisms of SRL in this context is relatively absent. We compared 'unguided' SRL with 'directed' SRL (DSRL), wherein learners followed an expert-designed booklet. Methods  Year 1 medical students (n = 37) were randomly assigned to ...
Li Fujing - - 2013
ABSTRACT: Hepatic ischemia-reperfusion (I/R) injury contributes to hepatic dysfunction and failure after liver transplantation, major hepatic resection, trauma, and hypovolemic shock. Therefore, reducing I/R injury is an important goal to improve the outcome of these procedures. Recently, high-mobility group box 1 protein (HMGB1) has been identified as a pathogenic mediator ...
Cordero-Coma Miguel - - 2013
Purpose: To establish evidence-based recommendations regarding the use of anti-Tumor Necrosis Factor alpha (TNF-α) agents for managing uveitis patients. Methods: Medline was searched via OVID (1950 - October Week 3, 2011) using a Cochrane highly sensitive search (phases 1 and 2). Additional literature searches were also conducted incuding the following ...
Pillay Mershen - - 2013
Abstract Wylie, McAllister, Davidson, and Marshal (2013) argued that the speech-language pathology profession must be encouraged to consider novel ways to deliver equitable services to people with communication disorders. People with communication disorders include the world's 215 million international migrants who deserve unique commentary when considering disability in the world. ...
Bleakley Alan - - 2013
CONTEXT  There is increasing interest in establishing the medical humanities as core integrated provision in undergraduate medicine curricula, but sceptics point to the lack of evidence for their impact upon patient care. Further, the medical humanities culture has often failed to provide a convincing theoretical rationale for the inclusion of ...
Kishore Sarita A - - 2013
Purpose: To report dislocation of dexamethasone implant (Ozurdex®) into the anterior chamber and to discuss intervention options. Design: Interventional case report. Methods: An 89-year-old woman presented after Ozurdex® implant injection for chronic cystoid macular edema secondary to idiopathic intermediate uveitis. The dexamethasone implant dislocated into the anterior chamber. Pharmacologic dilation ...
Troitzsch Dirk - - 2013
ABSTRACT: We hypothesized that pretreatment with single-dose cyclosporine (CsA) prevents alterations and improves tissue oxygen and mitochondrial cytochrome oxidase redox (CytOx) state in skeletal muscle ischemia and reperfusion-reoxygenation (I/R). Latissimus dorsi muscle was prepared and mobilized in New Zealand white rabbits. Ischemia was induced for 4 h, followed by 2 ...
Rees Charlotte E - - 2013
Introduction  Bedside teaching is essential for helping students develop skills, reasoning and professionalism, and involves the learning triad of student, patient and clinical teacher. Although current rhetoric espouses the sharing of power, the medical workplace is imbued with power asymmetries. Power is context-specific and although previous research has explored some ...
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