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Diderichsen Paul Matthias PM Quantitative Solutions BV, Breda, the - - 2013
To assess the cardiovascular effects of a new inhaled long-acting β-adrenoceptor agonist PF-00610355 in COPD patients. Thirteen thousand and sixty-two heart rate measurements collected in 10 clinical studies from 579 healthy volunteers, asthma and COPD patients were analyzed. The relationship between heart rate profiles and predicted plasma concentration profiles, patient ...
Valdez Carmen R CR Department of Counseling Psychology, University of Wisconsin, Madison, 301 Education Building, 1000 Bascom Mall, Madison, WI 53706, USA. - - 2013
Although it is widely accepted that parental depression is associated with problems with children's socioemotional adjustment, the pathways by which parental depression influences children's adjustment, particularly in low-income Latino children are not fully understood. In our investigation of 1,462 low-income Latino children in the first grade and their Spanish- and ...
Given J E JE Institute of Nursing Research, University of Ulster, Coleraine, UK. - - 2013
To synthesize evidence relating to comparisons between patient-generated blood glucose records and meter memory in diabetes and to identify any predictors of agreement. A systematic literature search was performed to identify articles comparing meter and diary records in those unaware of this assessment. Eleven observational studies, covering patients with Type ...
Hart Robert R Department of Orthopedics and Rehabilitation, Oregon Health and Science University, Portland, OR 97239, USA. - - 2013
Prospective cohort study. To assess the impact of postoperative post-traumatic stress disorder (PTSD) symptoms on clinical outcomes after lumbar arthrodesis. Postoperative PTSD symptoms occur among many patients who underwent elective lumbar fusion. Although adverse impact of preoperative depression and psychiatric distress has been described, no reports have assessed the impact ...
Wu Haifeng H School of Public Health and Family Medicine, Capital Medical University, Beijing 100069, - - 2013
The objective of this study was to investigate the method of the combination of radiological and textural features for the differentiation of malignant from benign solitary pulmonary nodules by computed tomography. Features including 13 gray level co-occurrence matrix textural features and 12 radiological features were extracted from 2,117 CT slices, ...
Tariq Anam A Department of Computer Engineering, College of E&ME, National University of Sciences and Technology, Rawalpindi, Pakistan. - - 2013
Diabetic maculopathy is one of the retinal abnormalities in which a diabetic patient suffers from severe vision loss due to the affected macula. It affects the central vision of the person and causes blindness in severe cases. In this article, we propose an automated medical system for the grading of ...
Rongkavilit Chokechai C The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI, USA. - - 2013
Healthy Choices, a four-session motivational interviewing-based intervention, reduces risk behaviors among US youth living with HIV (YLWH). We randomized 110 Thai YLWH (16-25 years) to receive either Healthy Choices or time-matched health education (Control) over 12 weeks. Risk behaviors were assessed at baseline, 1, and 6 months post-session. The pilot ...
Mizutani Nobuaki N Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Japan. - - 2013
Allergen-specific IgE has long been regarded as a major molecular component of allergic asthma. Additionally, there is increasing evidence of the important roles of interleukin-33 (IL-33) in the disease. Here, we show that IL-33 and alveolar macrophages play essential roles in the exacerbation of IgE-mediated airway inflammation and remodelling. BALB/c ...
Rafaelsen Silje Hjorth SH Department of Clinical Medicine, University of Bergen, Bergen, Norway. - - 2013
Fibroblast growth factor 23 (FGF23) plays a crucial role in renal phosphate regulation, exemplified by the causal role of PHEX and DMP1 mutations in X-linked hypophosphatemic rickets and autosomal recessive rickets type 1, respectively. Using whole exome sequencing we identified compound heterozygous mutations in family with sequence similarity 20, member ...
Fineberg Steven J SJ Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL 60612, - - 2013
Retrospective database analysis. A population-based database was analyzed to identify the incidence, risk factors, and mortality associated with thromboembolic events after lumbar spine surgery. Pulmonary embolism (PE) and deep vein thrombosis (DVT) are potential complications that may occur after orthopedic procedures. The incidence of these complications is not well characterized ...
Choi Su Mi SM Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2013
Patient-specific induced pluripotent stem cells (iPSCs) represent a potential source for developing novel drug and cell therapies. Although increasing numbers of disease-specific iPSCs have been generated, there has been limited progress in iPSC-based drug screening/discovery for liver diseases, and the low gene-targeting efficiency in human iPSCs warrants further improvement. Using ...
Görg Boris B Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine University, Düsseldorf, - - 2013
Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis and is seen as the clinical manifestation of a low-grade cerebral edema associated with oxidative-nitrosative stress. However, comprehensive data on HE-associated molecular derangements in the human brain are lacking. In the present study, we used a whole human genome microarray ...
Tao Yi-Ming YM Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, - - 2013
Epithelial-mesenchymal transition (EMT) is a critical step in the metastasis of hepatocellular carcinoma (HCC). BTB/POZ domain-containing protein 7 (BTBD7) regulates EMT-associated proteins implicated in HCC progression. However, the role(s) of BTBD7 in HCC have not been identified. Using highly metastatic HCC HCCLM3 cells, immortalized L02 hepatocytes, metastatic HCC animal models, ...
Kim Dae Hyun DH Division of Immunogenetics, Department of Pediatrics, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, - - 2013
The forkhead box O (FoxO) subfamily has four members, namely FoxO1, FoxO3, FoxO4, and FoxO6. Unlike the other three members of the FoxO family, FoxO6 has garnered considerably less attention because of earlier reports that FoxO6 expression was limited to the brain. Recent data indicate that FoxO6 is produced in ...
Gartland Matthew G MG Vanderbilt University School of Medicine, Nashville, Tennessee, - - 2013
To evaluate the effectiveness of maternal combination antiretroviral prophylaxis for prevention of mother-to-child transmission of HIV (PMTCT) in a program setting. Prospective cohort study. Nine primary care clinics in rural Zambia. Two hundred and eighty-four HIV-infected pregnant women at at least 28 weeks gestation initiating PMTCT services between April 2009 ...
Zanni Markella V MV Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. - - 2013
Among HIV-infected patients, high rates of myocardial infarction (MI) and sudden cardiac death have been observed. Exploring potential underlying mechanisms, we used multidetector spiral coronary computed tomography angiography (coronary CTA) to compare atherosclerotic plaque morphology in HIV-infected patients and non-HIV-infected controls. Coronary atherosclerotic plaques visualized by CTA in HIV-infected (101) ...
Peng Hui H Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Los Angeles, CA, - - 2013
Methionine adenosyltransferase 2B (MAT2B) encodes for two variant proteins (V1 and V2) that promote cell growth. Using in-solution proteomics, GIT1 (G Protein Coupled Receptor Kinase Interacting ArfGAP 1) was identified as a potential interacting partner of MAT2B. Here, we examined the functional significance of this interplay. Coimmunoprecipitation experiments examined protein ...
Moy Kristin A KA Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. - - 2013
Binding of advanced glycation end products (AGEs) to their receptor (RAGE) increases oxidative stress and inflammation and may be involved in liver injury and subsequent carcinogenesis. Soluble RAGE (sRAGE) may neutralize the effects mediated by the AGE/RAGE complex. Epidemiologic studies examining sRAGE or AGEs in association with liver cancer are ...
Grebely Jason J The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia. - - 2013
Systemic levels of interferon-gamma-inducible protein-10 (IP-10) are predictive of treatment-induced clearance in chronic hepatitis C virus (HCV). In the present study, factors associated with plasma IP-10 levels at the time of acute HCV detection and the association between IP-10 levels and spontaneous clearance were assessed in three cohorts of acute ...
Ceylan Bahadir - - 2013
We aimed to determine whether mean platelet volume (MPV) is one of the variables that determine the severity of liver fibrosis and inflammation. Patients with chronic hepatitis B virus (HBV) infection were divided into two groups: patients with fibrosis scores of 0-3 and 4-6 and patients with histologic activity index ...
Jones Edward L EL Department of Surgery, University of Colorado Denver, Aurora, CO 80045, - - 2013
To analyze the predictors and patterns of recurrence of melanoma in patients with a negative sentinel lymph node biopsy result. Retrospective chart review of a prospectively created database of patients with cutaneous melanoma. SETTING Tertiary university hospital. A total of 515 patients with melanoma underwent a sentinel lymph node biopsy ...
Chittaranjan Andrade A Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India. - - 2013
Depression and heart disease are commonly comorbid. Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression. In March 2011, we carried out a 15-year search of PubMed for preclinical and clinical publications related to SSRIs and ischemic heart disease (IHD) or congestive heart failure (CHF). We identify and ...
Davies M J MJ Department of Cardiovascular Sciences, University of Leicester, UK. - - 2013
To identify real-world factors affecting adherence to insulin therapy in patients with Type 1 or Type 2 diabetes mellitus. A literature search was conducted in PubMed and EMBASE in November 2011 to identify studies reporting factors associated with adherence/non-adherence to insulin therapy in adults with Type 1 or Type 2 ...
Stewart Kerry-Ann A KA Stanford University School of Medicine, Stanford, CA, - - 2013
To use a nationwide household survey tool to provide an estimate of injury prevalence, mechanisms of traumatic injuries, and number of injury-related deaths in a low-income country. A randomized, cross-sectional nationwide survey using the Surgeons OverSeas Assessment of Surgical Need tool was conducted in 2012. Sierra Leone, Africa. Three thousand ...
Deyo Richard A RA Department of Family Medicine, The Dartmouth Institute for Health Policy and Clinical Practice, USA. - - 2013
Retrospective cohort analysis of Medicare claims for 2006-2009. To examine whether interspinous distraction procedures are used selectively in patients with more advanced age or comorbidity, and whether they are associated with fewer complications, lower costs, and less revision surgery than laminectomy or fusion surgery. A manufacturer-sponsored randomized trial suggested an ...
Liang Frank F Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Stockholm, - - 2013
To study whether in-vivo recruitment of dendritic cells in response to antigen administration in the skin is altered during HIV-1 infection. Skin punch biopsies were collected from HIV-1-positive as well as seronegative individuals at 48 h after intradermal injection of inactivated antigens of mumps virus, Candida albicans, or purified protein ...
Dingsdale Hayley - - 2013
We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER-PM junctions formed near the leading edge of migrating cells (usually within 0.5 μm of polymerized actin and ...
Galanaud Jean-Philippe - - 2013
Post-thrombotic syndrome (PTS) refers to chronic manifestations of venous insufficiency following a deep-vein thrombosis (DVT). It is a frequent, chronic, burdensome and costly disease for which therapeutic options are limited. Above all, the optimal management of PTS consists of preventing its occurrence: first, by preventing DVT, and second, by preventing ...
Weiser Raphaella E - - 2013
Hemorrhagic Transformation (HT) has been well recognized as a common cause of hemorrhage in ischemic stroke patients. Though this complication may occur independently, it has been particularly dreaded in the post rTPA patient and thus has been the focus for analysis of multiple thrombolytic trials. This review examines the effect ...
Ehrmann Stephan S Service de Réanimation Médicale Polyvalente, CHRU de Tours, Tours, France. - - 2013
To assess whether the use of iodinated contrast medium increases the incidence of acute kidney injury in ICU patients, compared with patients not receiving iodinated contrast medium. Prospective observational matched cohort study. Two ICUs in two tertiary teaching hospitals. A total of 380 adults were included (20% more than once), ...
Arzberger Edith E Department of Dermatology, Medical University of Graz, Graz, - - 2013
Zoon plasma cell balanitis is a benign inflammatory disease of genital skin. It may be difficult to clinically distinguish between balanitis and carcinoma in situ (CIS); thus, a biopsy may be needed to exclude malignant disease. Reflectance confocal microscopy (RCM) is an in vivo imaging method to get morphologic information ...
Jambusaria-Pahlajani Anokhi A Department of Dermatology, Mayo Clinic Florida, Jacksonville, - - 2013
This study proposes an alternative tumor staging system for cutaneous squamous cell carcinoma (CSCC) that more precisely defines the small subset of tumors with a high risk of metastasis and death. To identify risk factors for poor outcomes in CSCC and evaluate the 2010 American Joint Committee on Cancer (AJCC) ...
Jaimes Natalia N Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10022, - - 2013
To describe and analyze the clinical and dermoscopic characteristics of desmoplastic melanoma (DM) as a function of pathologic subtype and phenotypic traits. Retrospective case series. Eight high-risk dermatology clinics. Patients with DM confirmed by histopathologic analysis whose records included a high-quality dermoscopic image. Clinical, dermoscopic, and histopathologic features of DM. ...
Zabielinski Marilyn M Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, - - 2013
To determine whether the relative proportions of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S aureus (MSSA) were changing or stable in an outpatient dermatology clinic and to examine the antibiotic susceptibility profiles of S aureus isolates. Retrospective observational data were collected from skin culture isolates annually between January 1, 2005, ...
Chang Chih-Hao CH Department of Electrical Engineering, National Chiao Tung University, Hsinchu, - - 2013
Remarkable changes in cardiorespiratory interactions are frequently experienced by Chan meditation practitioners following years of practice. This study compares the results of our study on cardiorespiratory interactions for novice (control group) and experienced (experimental group) Chan meditation practitioners. The effectual co-action between the cardiac and respiratory systems was evaluated by ...
Wolf Joel A JA University of Pittsburgh, Pittsburgh, Pennsylvania 15213, - - 2013
To measure the performance of smartphone applications that evaluate photographs of skin lesions and provide the user with feedback about the likelihood of malignancy. Case-control diagnostic accuracy study. Academic dermatology department. PARTICIPANTS AND MATERIALS: Digital clinical images of pigmented cutaneous lesions (60 melanoma and 128 benign control lesions) with a ...
Hettema John M JM Departments of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA 23298-0126, - - 2013
Quantitative trait loci identified in animal models provide potential candidate susceptibility loci for human disorders. In this study, we investigated whether internalizing disorders (anxiety disorders, major depression, and neuroticism) were associated with a region on human chromosome 1 syntenic with a quantitative trait locus for rodent emotionality. We genotyped 31 ...
Hanson Josh P JP Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. - - 2013
To evaluate the efficacy and safety of liberal fluid resuscitation of adults with severe malaria. DESIGN, SETTING, PATIENTS, AND METHODS: Twenty-eight Bangladeshi and Indian adults with severe falciparum malaria received crystalloid resuscitation guided by transpulmonary thermodilution (PiCCO) in an intensive care setting. Systemic hemodynamics, microvascular indices and measures of acidosis, ...
Schalekamp Maarten A D H MA Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The - - 2013
A kinetic model for the binding of angiotensin II (Ang II) to AT1 receptors (AT1Rs) in arterioles did suggest a novel mechanism of association rate amplification and facilitated Ang II diffusion in vivo. To examine how this mechanism, acting on AT1R, will affect the stimulation of AT2R. The model distinguishes ...
Hommel Kevin A KA Division of Behavioral Medicine and Clinical Psychology, Center for the Promotion of Treatment Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, MLC 7039, Cincinnati, OH 45229-3039, USA. - - 2013
To evaluate an individually tailored multicomponent nonadherence treatment protocol using a telehealth delivery approach in adolescents with inflammatory bowel disease. Nine participants, age 13.71±1.35 years, completed a brief treatment online through Skype. Medication nonadherence, severity of disease, and feasibility/acceptability data were obtained. Adherence increased markedly from 62% at baseline to ...
McLoughlin Fionn - - 2013
PA (phosphatidic acid) is a lipid second messenger involved in an array of processes occurring during a plant's life cycle. These include development, metabolism, and both biotic and abiotic stress responses. PA levels increase in response to salt, but little is known about its function in the earliest responses to ...
Kras Jeffrey V JV Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6392, - - 2013
This study used retrograde neuronal tracing and immunohistochemistry to identify neurons innervating the C6-C7 facet joint and those expressing calcitonin gene-related peptide (CGRP) in the dorsal root ganglion (DRG) of rats after painful cervical facet joint injury. The objective of this study was to characterize the innervation of the C6-C7 ...
Maliken Bryan D BD Center for Liver Disease, Digestive Disease Institute and Benaroya Research Institute, Virginia Mason Medical Center, Seattle, WA, - - 2013
The aim of this study was to examine the relationship between the presence of hepatic iron deposition, apoptosis, histologic features, and serum markers of oxidative stress (OS) and cell death in nonalcoholic fatty liver disease (NAFLD). Clinical, biochemical, metabolic, and independent histopathologic assessment was conducted in 83 unselected patients with ...
Shah Chirag M - - 2013
Scapholunate advanced collapse (SLAC) and scaphoid nonunion advanced collapse (SNAC) are the two most common patterns of posttraumatic wrist arthritis. This review discusses the etiology and clinical evaluation, as well as up-to-date treatment options, for both of these conditions. Classic as well as newer innovative techniques are discussed with clinical ...
Bekeredjian R - - 2013
Aortic valve stenosis is the most prevalent, clinically significant valvular disorder in adult patients. Surgical valve replacement is the standard therapy for patients with symptomatic and severe aortic stenosis; however, many patients are suboptimal candidates for surgery due to age and co-morbidities. The development of transcatheter aortic valve implantation (TAVI) ...
Hodson Leanne L Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK. - - 2013
The fatty acid, palmitoleate (16:1 nā€Š-ā€Š7), has received a lot of attention in recent years for being 'lipokine' and for the first time, we review the evidence to determine if there is something special about palmitoleate in humans. Despite dietary intakes being low (<4% of total energy) palmitoleate is the ...
MacCabe James H JH Department of Psychosis Studies, Institute of Psychiatry, King's College London, London, England. - - 2013
Clear evidence from many prospective, population-based studies indicates that patients who develop psychosis in adulthood experienced various cognitive deficits during childhood and adolescence. However, it is unclear whether these deficits become more severe during adolescence. To assess the influence of cognitive developmental trajectories in adolescence and young adulthood on the ...
Fitzsimmons Jennifer J Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. - - 2013
We review diffusion tensor imaging (DTI) studies that investigate white matter abnormalities in patients with chronic schizophrenia, first episode schizophrenia, and those who are at genetic risk for developing schizophrenia. Additionally, we include studies that combine DTI and functional MRI (fMRI) to investigate brain connectivity abnormalities. Schizophrenia is a complex ...
Ellsworth Katarzyna A KA Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, - - 2013
FKBP51 (51 kDa immunophilin) acts as a modulator of the glucocorticoid receptor and a negative regulator of the Akt pathway. Genetic variation in FKBP5 plays a role in antidepressant response. The aim of this study was to comprehensively assess the role of genetic variation in FKBP5, identified by both Sanger ...
Guha Saurav S Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, New York 11004, - - 2013
Large genomic copy number variations have been implicated as strong risk factors for schizophrenia. However, the rarity of these events has created challenges for the identification of further pathogenic loci, and extremely large samples are required to provide convincing replication. To detect novel copy number variations that increase the susceptibility ...
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