Search Results
Results 401 - 450 of 3031
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Sarig Galit - - 2013
Association between cancer and thrombosis is well-known and occurrence of thrombotic complications in patients with malignancies commonly correlates with poor prognosis[1]. The protein C pathway is the main natural in-vivo anticoagulant mechanism and abnormalities such as acquired activated protein C (APC) resistance or congenital APC resistance, mostly due to factor ...
O'Neill Luke A J LA School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland. - - 2013
Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1α and AMP-activated protein kinase have been proposed. By contrast, ...
Wuerfel Oliver - - 2013
In the environment, the methylation of metal(loid)s is a widespread phenomenon, which enhances both biomobility as well as mostly the toxicity of the precursory metal(loid)s. Different reaction mechanisms have been proposed for arsenic, but not really proven yet. Here, carbon isotope analysis can foster our understanding of these processes, as ...
Chokkanathan Srinivasan - - 2013
To examine the psychometric properties of the 20-item Centre for Epidemiological Studies - Depression scale (CES-D). Data were collected from 400 community-dwelling older adults aged 65 years and above, residing in Chennai, India. The instruments including the CES-D scale were translated into Tamil language. The sample was randomly split for ...
Gui Dingkun - - 2013
Oxidative stress and apoptosis play key role in the pathogenesis of acute kidney injury (AKI). We hypothesize that Astragaloside IV(AS-IV) prevents AKI through inhibiting oxidative stress and apoptosis. The rats were divided into sham control, saline-,vehicle-, or AS-IV-treated groups. AS-IV (20 mg/kg) was orally administered once daily to the rats for ...
Wang Yun-Chao - - 2013
A new 2,5-diketopiperazine, (R)-2-(2-(furan-2-yl)-oxoethyl)-octahydropyrrolo[1,2-a]pyrazine-1,4-dione, and seven known compounds were isolated from the ethyl acetate extract of liquid fermentation broth of Armillaria mellea. The structures of the isolated compounds were established from NMR and HR-MS data. The absolute configuration of the new compound was established by comparing the experimental electronic circular ...
Terencio Maria Leandra - - 2013
The possible origins and differentiation of a ZZ/ZW sex chromosome system in Semaprochilodus taeniurus, the only species of the family Prochilodontidae known to possess heteromorphic sex chromosomes, were examined by conventional (C-banding) and molecular (cross-species hybridization of W-specific WCP, Fluorescence in situ hybridization (FISH) with telomere (TTAGGG)n, and Rex1 probes) ...
Hatano Manabu - - 2013
A facile, atom-economical, and chemoselective esterification is crucial in modern organic synthesis, particularly in the areas of pharmaceutical, polymer, and material science. However, a truly practical catalytic transesterification of carboxylic esters with various alcohols has not yet been well established, since, with many conventional catalysts, the substrates are limited to ...
Sun Wei - - 2013
Abstract Tyrosinases (monophenol monooxygenases, EC 1.14.18.1) utilize a reaction mechanism that involves two intertwined catalytic cycles and at least three different ligand-binding enzyme forms. Therefore a variety of different inhibition types may arise in inhibition experiments, depending on the binding mode of the compound studied. Here we discuss a steady-state ...
Dermody Sarah S - - 2013
Sexual minority (lesbian and gay, bisexual, mostly heterosexual) individuals are at an increased risk for hazardous drinking than heterosexual individuals, but little is known about the nature of the disparities as adolescents reach adulthood. We used four waves of a nationally representative data set, the National Longitudinal Study of Adolescent ...
Rasool Shabhat - - 2013
This study looks at novel variants of the TGFβ1 gene and their potential association with high myopia in an ethnic population from Kashmir, India. Allele frequencies of 247 Kashmiri subjects (from India) with high myopia and 176 ethnically matched healthy controls were tested for Hardy-Weinberg disequilibrium. The genotype and allele ...
Lai Yue Sum Sharon - - 2013
This qualitative study aimed to examine the inclusive practices implemented in three faith-based kindergartens in Hong Kong. A questionnaire was used to collect information about school backgrounds, students' special needs, teacher training, special education services, curriculum design, school policy, parental involvement, and challenges faced by these schools when implementing their ...
Mendoza Natasha S - - 2013
The majority of drug abusing offenders who need substance abuse treatment do not receive it. Although interventions like drug court increase the probability of offender success, little is known about how co-occurring psychological symptoms impact drug court treatment outcomes. Based on previous research, we hypothesized that co-occurring psychological symptoms would ...
Yang Shuying - - 2013
PURPOSE: The objective of this work was to describe the losmapimod concentration-QT relationship using meta-analysis of data from clinical trials with healthy volunteers and to evaluate the covariates that have significant impact on the QT prolongation. METHODS: Losmapimod plasma concentration and QT interval data were collected from six early clinical ...
Rizzo Victoria M - - 2013
PURPOSE: Multiple group analysis is used to determine whether the health-related quality of life (HRQoL) model developed by Wilson and Cleary (1995) is equivalent across racial categories. Using data from the Centers for Disease Control's Behavioral Risk Factor Surveillance System, this study compares racial groups (African American vs. White; Hispanic ...
Weber Jesse N - - 2013
Relative to morphological traits, we know little about how genetics influence the evolution of complex behavioural differences in nature. It is unclear how the environment influences natural variation in heritable behaviour, and whether complex behavioural differences evolve through few genetic changes, each affecting many aspects of behaviour, or through the ...
Kasetti Yoganjaneyulu - - 2013
Several therapeutically important compounds contain guanylurea (GU) moiety. The appropriate tautomeric state of these species has not been explored, preliminary studies indicated that the traditional representation of this class of compounds use a high energy tautomeric state. In this work, quantum chemical studies (HF, B3LYP, MP2, G2MP2 and CBS-Q methods) ...
Kaplancikli Zafer Asim - - 2013
Abstract In this study, 14 different 2-[(1-methyl-1H-tetrazole-5-yl)thio]-1-(phenyl)ethanone derivatives (1-14) were synthesized. The structures of the obtained compounds were elucidated using IR, (1)H-NMR, (13)C-NMR and FAB(+)-MS spectral data and elemental analyses results. The compounds were screened for their anticandidal activity using the microbroth dilution method and for their cytotoxic effects using ...
Zhu Yuelin - - 2013
ABSTRACT: BACKGROUND: The Sequence Read Archive (SRA) is the largest public repository of sequencing data from the nextgeneration of sequencing platforms including Illumina (Genome Analyzer, HiSeq, MiSeq, .etc),Roche 454 GS System, Applied Biosystems SOLiD System, Helicos Heliscope, PacBio RS, andothers. RESULTS: SRAdb is an attempt to make query of the ...
Leonelli Mauro - - 2013
The activation of the transient receptor potential vanilloid type 1 channel (TRPV1) has been correlated with oxidative and nitrosative stress and cell death in the nervous system. Our previous results indicate that TRPV1 activation in the adult retina can lead to constitutive and inducible nitric oxide synthase-dependent protein nitration and ...
Furusawa Takuro - - 2013
Human essential hypertension is partly caused by genetic factors. Angiotensinogen (AGT), G-protein β3-subunit (GNB3) and cytochrome P450 3A5 (CYP3A5) are candidate hypertension susceptibility genes and risk alleles at these loci have been thought to arise owing to human adaptation to climatic changes following the migration out-of-Africa. This study aimed to ...
Arriaga Alexander F - - 2013
Operating-room crises (e.g., cardiac arrest and massive hemorrhage) are common events in large hospitals but can be rare for individual clinicians. Successful management is difficult and complex. We sought to evaluate a tool to improve adherence to evidence-based best practices during such events. Operating-room teams from three institutions (one academic ...
Ebert Daniel H DH Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, - - 2013
Neuronal activity induces the post-translational modification of synaptic molecules, promotes localized protein synthesis within dendrites and activates gene transcription, thereby regulating synaptic function and allowing neuronal circuits to respond dynamically to experience. Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of ...
Masi A - - 2013
BACKGROUND AND PURPOSE: 1-methyl-4-phenylpyridinium (MPP(+) ), a potent parkinsonizing agent in primates and rodents, is a blocker of mitochondrial complex I, therefore MPP(+) -induced parkinsonism is believed to depend largely on mitochondrial impairment. However, it has recently been proposed that other mechanisms may participate in MPP(+) -induced toxicity. We tackled ...
Bernardin Fanny - - 2013
A 5 mo old female rottweiler was referred for evaluation of a suspected congenital heart disease. Clinical signs included anorexia, exercise intolerance, and severe loss of body condition. Clinical examination revealed dyspnea, pale mucous membranes, and weak femoral pulses. Pleural and abdominal effusions and iron deficiency anemia were identified. A ...
Van Camp Jasmijn K - - 2013
Because of the importance of the Wnt pathway in the development and maintenance of both adipose and bone tissue, we wanted to evaluate the involvement of WNT10B, a Wnt pathway activator, in adipogenesis and osteoblastogenesis in humans. Genetic association between WNT10B polymorphisms and adiposity parameters as well as bone mineral ...
Lee Soyean - - 2013
This study examined the validity of the sluggish cognitive tempo (SCT) symptom dimension in children. Ten symptom domains were used to define SCT (i.e., (1) daydreams; (2) attention fluctuates; (3) absent-minded; (4) loses train of thought; (5) easily confused; (6) seems drowsy; (7) thinking is slow; (8) slow-moving; (9) low ...
Ahmad Zeeshan - - 2013
This study presents a case series of patients with meningococcal purpura fulminans who were treated at a tertiary referral centre within a few days of each other. Presenting with signs and symptoms of florid meningococcal sepsis, they were managed initially by physicians and intensivists, whereas the development of large purpuric ...
Berg Anne Ingeborg - - 2013
Objectives: Mild cognitive impairment (MCI) is a state of mildly impaired cognitive functioning but with an intact capability of performing basic daily activities. Few studies have targeted personal narratives from persons living with MCI, the major focus in this study is directed to methods for better predictions of the likelihood ...
Sørensen Nikolaj - - 2013
Published results of studies based on samples size fractionated by sequential filtration (e.g. 0.2-3 μm) indicate that many ciliate, dinoflagellate and rhizarian phylotypes are found among marine picoeukaryotes. This is somewhat surprising as these protists are typically known as being large organisms (often >10 μm) and no picoplanktonic species have so far ...
Brin Yaron S YS Department of Orthopaedic Surgery, Meir Medical Center, Tel-Aviv University, Kfar-Saba, Israel. - - 2013
Anatomical reduction and fixation of unstable ankle fractures is necessary to prevent post-traumatic arthritis. Malunion of the distal fibula in unstable ankle fractures can lead to late degenerative changes of the ankle. Late reconstruction of the ankle can improve its function and postpone the need for ankle fusion or replacement. ...
Michalke B - - 2013
Occupational manganese (Mn) overexposure leads to accumulation in the brain and has been shown to cause progressive, permanent, neuro-degenerative damage with syndromes similar to idiopathic Parkinsonism. Mn is transported by an active mechanism across neural barriers (NB) finally into the brain; but to date, modes of Mn neurotoxic action are ...
Schulman S - - 2013
Anticoagulation with warfarin is the leading cause for emergency hospitalizations due to adverse drug events in elderly Americans [1]. In one third of those events warfarin alone or in combination with other dugs was identified as the cause. Antiplatelet agents were the third leading cause (13.3%) and thus in half ...
Longeri M M Dip. Scienze Veterinarie e Sanità Pubblica, University of Milan, Milan, Italy. - - 2013
Two mutations in the MYBPC3 gene have been identified in Maine Coon (MCO) and Ragdoll (RD) cats with hypertrophic cardiomyopathy (HCM). This study examined the frequency of these mutations and of the A74T polymorphism to describe their worldwide distribution and correlation with echocardiography. 1855 cats representing 28 breeds and random-bred ...
Vietri Jeffrey - - 2013
ABSTRACT: BACKGROUND: Few studies have examined the impact of Hepatitis C virus (HCV) infection on patient reported outcomes in Europe. This study was conducted to assess the burden of HCV infection in terms of work productivity loss, activity impairment, health-related quality of life, healthcare resource utilization, and associated costs. METHODS: ...
Zelinová Veronika - - 2013
The purpose of this study was to analyse the alterations of glutathione peroxidase (GPX) expression and activity during the recovery period after a short-term treatment of barley root tip with cadmium (Cd) and hydrogen peroxide (H(2)O(2)). The transcript level of GPX increased as early as 1 h and GPX activity 3 h ...
Chen Xiujuan - - 2013
A pyridinyl-functionalized tetraphenylethene (Py-TPE) was synthesized and it demonstrated colorimetric and ratiometric fluorescent responses to trivalent metal cations (M(3+), M = Cr, Fe, Al) over a variety of mono- and divalent metal cations.
Littman Meryl P MP Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine-Philadelphia, Philadelphia, PA 19104-6010, USA. - - 2013
Dogs of the soft-coated wheaten terrier breed (SCWT) are predisposed to adult-onset, genetically complex, protein-losing nephropathy (average onset age = 6.3 ± 2.0 years). A genome-wide association study using 62 dogs revealed a chromosomal region containing three statistically significant SNPs (p(raw) ≤ 4.13 × 10(-8); p(genome) ≤ 0.005) when comparing ...
Castro-Gamero Angel Mauricio AM Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil, - - 2013
Chromosomal heterogeneity is a hallmark of most tumors and it can drive critical events as growth advantages, survival advantages, progression and karyotypic evolution. Medulloblastoma (MB) is the most common malignant central nervous system tumor in children. This work attempted to investigate chromosomal heterogeneity and instability profiles of two MB pediatric ...
Rychel Jessica - - 2013
This case report highlights an unusually prolonged, asymptomatic, disease-free interval in an aged male Labrador retriever that underwent partial pancreatectomy for a functionally active pancreatic insulinoma with histologically confirmed hepatic metastasis. The patient developed pancreatitis and nonseptic suppurative peritonitis 24 hr after surgical resection of the insulinoma and was managed ...
Abdelrazzaq Khalil - - 2013
OBJECTIVE: To identify the role of longitudinal measurements of fetal aortic isthmus blood flow using Doppler ultrasonography in the prediction of perinatal morbidity and mortality. SETTING: Obstetrics department of a university POPULATION AND DESIGN: This prospective study includes women with fetal growth restriction and abnormal umbilical artery Doppler results, seen ...
Bergman Michael - - 2013
Diagnosis of dysglycemic states is likely delayed as current diagnostic criteria apply absolute threshold values to a process that is continuous. The importance of this relates to forestalling opportunities for earlier diagnosis when prevention and reversibility are more likely to occur by preventing further β cell dysfunction. Although the optimal ...
Ochoa Victoria - - 2013
The aim of this study was to determine heavy metal content (As, Cd, Cu, Hg, Cd, Pb, and Zn) in oysters transplanted in Ebro Delta bays (Alfacs and Fangar) where oysters are traditionally cultured for human consumption. Metal body burdens were monitored weekly during the period of maximal agriculture activity ...
Casaluce Francesca - - 2013
The anaplastic lymphoma kinase (ALK) fusion gene is a key oncogenic driver in a subset of patients with advanced non-small cell lung cancer (NSCLC). Oncogenic fusion genes, including echinoderm microtubule-associated protein-like 4 (EML4) and ALK, have been detected in approximately 2-7 % of NSCLC patients. Fluorescence in situ hybridization (FISH) is ...
Suzuki Tadahiro - - 2013
Zymolyase (lyticase) is used for cell wall digestion in yeast experiments and is needed for incubation processes under moderate experimental conditions. This has been thought to cause unfavorable effects, and many researchers are aware that the enzyme method is unsuitable for RNA preparation following several reports of stress responses to ...
Uchida Mitsuo - - 2013
Although the natural history of H1N1 has been found to vary among patients, little is known about the factors that affect these variations. Infected patients with an extended infection history may shed virus longer and spread infection. To further clarify these variations, we evaluated the natural history of H1N1 infection ...
Zheng Chao - - 2013
Molecularly imprinted monoliths integrate the high permeability of monolithic materials and the high selectivity and affinity of molecularly imprinted polymers (MIP). Thus, in recent years, development of this novel MIP format in HPLC has expanded quickly, particularly use of organic materials. This review focuses on the principal aspects of good ...
Lee Junseok - - 2013
A photoresponsive drug releasing system based on mesoporous silica nanoparticles (MSN) was developed. A model drug was decorated on the surfaces via singlet oxygen sensitive linkers and a singlet oxygen-generating photosensitizer was loaded in the mesopores of the MSN. An on-demand drug releasing system was successfully developed by irradiation with ...
Zhang Peng - - 2013
Inflammation is an immune response against a variety of noxious stimuli, such as infection, chemicals, and physical injury. Eugenol, a natural phenolic extract, has drawn much attention for its various desirable pharmacological functions and is, therefore, broadly used in our daily life and medical practice. However, further usage of eugenol ...
Beydoun Hind H Graduate Program in Public Health, Eastern Virginia Medical School, Norfolk, VA 23501-1980, USA. - - 2013
The purpose of this cross-sectional study based on the 2001-2006 National Health and Nutrition Examination Survey is to examine demographic, socioeconomic, lifestyle and reproductive characteristics that may distinguish users and non-users of insulin sensitizing agents among the US diabetic, borderline diabetic and non-diabetic women. Use of insulin-sensitizing agents was evaluated ...
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