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Holloway Terrell - - 2013
It has been suggested that severe adverse life events during pregnancy increase the risk of schizophrenia in the offspring. The serotonin 5-HT(2A) and the metabotropic glutamate 2 (mGlu2) receptors both have been the target of considerable attention regarding schizophrenia and antipsychotic drug development. We tested the effects of maternal variable ...
Endlein Thomas T Centre for Cell Engineering, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, UK. - - 2013
To live and clamber about in an arboreal habitat, tree frogs have evolved adhesive pads on their toes. In addition, they often have long and slender legs to facilitate not only long jumps, but also to bridge gaps between leaves when climbing. Both adhesive pads and long limbs are used ...
Sasaki Kentaro - - 2013
Bacterial cold shock proteins (CSPs) act as RNA chaperones that destabilize mRNA secondary structures at low temperatures. Bacterial CSPs are composed solely of a nucleic acid-binding domain termed the cold shock domain (CSD). Plant CSD proteins contain an auxiliary domain in addition to the CSD but also show RNA chaperone ...
Urbizu Aintzane - - 2013
BACKGROUND AND PURPOSE: The diagnosis of Chiari malformation type I (CMI) relies on MRI identification of a tonsillar descent (TD) through the foramen magnum, reflecting the overcrowding of an underdeveloped posterior cranial fossa (PCF). However, TD occurs in some patients with normal-sized PCF and, conversely, some patients with borderline or ...
Wang Jiangwei - - 2013
Lithium-ion batteries have revolutionized portable electronics, and will be key to electrifying transport vehicles and delivering renewable electricity. Amorphous silicon (a-Si) is being intensively studied as a high-capacity anode material for next-generation lithium-ion batteries. Its lithiation has been widely thought to occur through a single-phase mechanism with gentle Li profiles, ...
Reeder Blaine B Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA 98195, USA. - - 2013
Older adults with multiple chronic conditions face the complex task of medication management involving multiple medications of varying doses at different times. Advances in telehealth technologies have resulted in home-based devices for medication management and health monitoring of older adults. We examined older adults' perceptions of a telehealth medication dispensing ...
Chapman Karen P - - 2013
We previously showed that the splanchnic bed of neonates takes up a significantly higher amount (43%) of threonine in contrast to lysine (12%). We questioned whether this same pattern applied in adult humans and found no information in the literature. Therefore, our objective in the current study was to determine ...
Yıldız Ozkan - - 2013
Process improvement activities are becoming an essential part of a number of healthcare organizations. As the popularity of process improvement grows, the need for common objective measures is becoming more critical. Numerous quality measures have been suggested to evaluate healthcare quality. However, applications utilizing the existing quality measures mostly focus ...
Nash Kendall B - - 2013
Hospitalist medicine has gown rapidly over the past decade in response to increasing complexity of hospitalized patients, financial pressures, and a national call for improved quality and safety outcomes. An adult neurohospitalist model of care has recently emerged to address these factors and the need for inpatient neurologists who offer ...
McDaniel Ashley M - - 2013
We report the preparation, photophysical characterization, and computed excited state energies for a family of Cr(III) complexes based on iminopyridine (impy) Schiff base ligands: compounds 1 and 2 feature hexadentate ligands where tren (tris-(2-aminoethyl)amine) caps three impy groups; compounds 3 and 4 are tris(bidentate) analogues of 1 and 2; compounds ...
Hou Shenglei - - 2013
Antisense oligodeoxynucleotides (ASODNs) can bind to some specific RNA of survivin can prevent the mRNA translation at the genetic level, which will inhibit survivin expression and make the cancer cells apoptosis. However, the ASODNs-based therapies are hampered by their instability to cellular nuclease and their weak intracellular penetration. Here we ...
Bounaadja Lotfi - - 2013
Evaluation of candidate antiviral drugs against Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), and HHV-8 is hampered by the lack of convenient laboratory assays. We developed real-time quantitative PCR assays performed on supernatants of lymphoma cell lines and determined the 50% inhibitory concentrations (IC50s) of nucleoside, nucleotide, and pyrophosphate analogues ...
Kaminski Pierre Alexandre PA Institut Pasteur, Unité de Chimie et Biocatalyse, CNRS, UMR 3523, 75724 Paris cedex 15, France. - - 2013
A large number of nucleoside analogues and 2'-deoxynucleoside triphosphates (dNTP) have been synthesized to interfere with DNA metabolism. However, in vivo the concentration and phosphorylation of these analogues are key limiting factors. In this context, we designed enzymes to switch nucleobases attached to a deoxyribose monophosphate. Active chimeras were made ...
Tang Jinhua - - 2013
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase. Its activation results in beneficial or detrimental consequences, depending on the particular setting. Earlier studies in the animal model of acute kidney injury showed that EGFR activation promotes renal tubular cell proliferation. Activation of EGFR by its exogenous ligands, like ...
Cougot Nicolas N Université de Rennes 1, UMR, CNRS 6290 IGDR, Translation and Folding Team, Campus de Beaulieu, Rennes Cedex, - - 2013
A finely tuned balance of translation, storage and decay of mRNAs (mRNAs) is important for the regulation of gene expression. In eukaryotic cells, this takes place in dynamic cytoplasmic RNA-protein granules termed Processing bodies (P-bodies). In this study, by using immunoelectron tomography, 3D modeling and template matching, we analyze the ...
Popovich Kyle J KJ Rush University Medical Center, Stroger Hospital of Cook County, and University of Illinois at Chicago Medical Center, Chicago, Illinois 60612, USA. - - 2013
The epidemic of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has had a disproportionate impact on patients with human immunodeficiency virus (HIV). We evaluated CA-MRSA colonization burden (number of colonized sites per total number sampled) among HIV-infected and HIV-negative inpatients within 72 hours of hospitalization. From March 2011 through April 2012, we ...
Yoshida Masashi M Yoshida Pediatric Clinic; Osaka, - - 2013
A 69-y-old man with a history of hepatitis C since May 1985 and his 6 healthy immediate relatives were examined for hemagglutination inhibition antibodies against 2009 pandemic influenza A/H1N1 virus. This patient had a hemagglutination inhibition antibody titer of 640 against 2009 pandemic influenza A/H1N1 virus in a serum sample ...
Guo Lai-Jing LJ Department of Physiology, Emory University School of Medicine and the Center for Cell and Molecular Signaling, Atlanta, GA 30322, - - 2013
Epithelial sodium channels (ENaCs) located at the apical membrane of polarized epithelial cells are regulated by the second messenger guanosine 3',5'-cyclic monophosphate (cGMP). The mechanism for this regulation has not been completely characterized. Guanylyl cyclases synthesize cGMP in response to various intracellular and extracellular signals. We investigated the regulation of ...
Tesfay Mulu Z - - 2013
We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized in the bone marrow. One of the presumed advantages for using VSV as an oncolytic virus is that human infections are rare and preexisting anti-VSV ...
Ko Yeoung-Gyu - - 2013
DNA methyltransferase1o (Dnmt1o), which is specific to oocyte and preimplantation embryo, plays a role in maintaining DNA methylation in mammalian cells. Here, we investigated the methylation status of CpGs sites in the Dnmt1o 5'-flanking region in germ cells at different stages of oogenesis or spermatogenesis. The methylation levels of the ...
Demming Anna - - 2013
People working in device design rarely see something that works without thinking how it could be made to work better. The work on anodic aluminum oxide materials in this issue provides a case in point [1]. Over the past century researchers have observed, manipulated and exploited the porous structures that ...
Abreu S - - 2013
What is already known about this subject Diet and physical activity (PA) are recognized as important factors to prevent abdominal obesity (AO). Studies have found an inverse relationship between milk intake or milk products and body weight and/or body fat in children and adolescents. Evidence suggests that low levels of ...
Cross Bethany S - - 2013
OBJECTIVE:To retrospectively examine the utility of high-dose oral medroxyprogesterone (MPA) for the treatment of inappropriate hypersexuality (IH) in elderly men with dementia.CASE SUMMARY:Ten men aged 65 years or older (median 79.5 years, range 65- 93 years) were identified from all admissions at a 170-bed tertiary referral psychiatric hospital between December ...
Takeda Seiji - - 2013
We have compiled our recent in-situ quantitative environmental transmission electron microscopy (ETEM) studies on typical gold nanoparticulate catalysts for the low-temperature oxidation of CO to describe the issues surrounding the application of ETEM, with a special regard to catalyst chemistry. Thanks to the recent development of high-resolution environmental transmission electron ...
Jones Heidi E - - 2013
Women participating in studies in Brazil (n = 695) and South Africa (n = 230) performed rapid point-of-care tests for Trichomonas vaginalis on self-collected vaginal swabs. Using PCR as the gold standard, rapid self-testing achieved high specificity (99.1%; 95% confidence interval [CI], 98.2 to 99.6%) and moderate sensitivity (76.7%; 95% ...
Puri Pawan - - 2013
The blood testis barrier (BTB) is a large junctional complex composed of tight junctions, adherens junctions and gap junctions between adjacent Sertoli cells in the seminiferous tubules of the testis. Maintenance of the BTB as well as the controlled disruption and reformation of the barrier is essential for spermatogenesis and ...
Gankam-Kengne Fabrice - - 2013
Hyponatremia is a common disorder associated with higher mortality in hospitalized patients, but its impact in an ambulatory setting remains unclear. Here we used data from the Dallas Heart Study, a prospective multiethnic cohort study that included ambulatory individuals, to determine the prevalence and determinants of hyponatremia (serum sodium <135 mEq/l), ...
Markham Michael R MR Section of Neurobiology and Institute for Neuroscience, The University of Texas at Austin, Austin, TX, USA. - - 2013
We investigated the ionic mechanisms that allow dynamic regulation of action potential (AP) amplitude as a means of regulating energetic costs of AP signaling. Weakly electric fish generate an electric organ discharge (EOD) by summing the APs of their electric organ cells (electrocytes). Some electric fish increase AP amplitude during ...
Gan Haiyun H State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, PR - - 2013
Mammalian spermatogenesis consists of many cell types and biological processes and serves as an excellent model for studying gene regulation at transcriptional and post-transcriptional levels. Many key proteins, miRNAs, and perhaps piRNAs have been shown to be involved in post-transcriptional regulation of spermatogenesis. However, a systematic method for assessing the ...
Jokela M - - 2013
BACKGROUND: Ageing is an important factor in the development of mental health problems and their treatment. We assessed age trajectories of common mental disorders (CMDs) and psychotherapy utilization from adolescence to old age, and examined whether these trajectories were modified by time period or birth cohort effects. Method British Household ...
van Nood Els E Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2013
Recurrent Clostridium difficile infection is difficult to treat, and failure rates for antibiotic therapy are high. We studied the effect of duodenal infusion of donor feces in patients with recurrent C. difficile infection. We randomly assigned patients to receive one of three therapies: an initial vancomycin regimen (500 mg orally ...
Chartsrisak Kamonwan - - 2013
ABSTRACT: BACKGROUND: Marked hyperphosphatemia, hyperparathyroidism and 25-hydroxyvitamin D deficiency are associated with mortality in dialysis patients. Such data in chronic kidney disease stage 2--4 population are limited. It has been suggested that high-normal serum phosphate predicts worse renal and patient outcomes. The data regarding parathyroid hormone and outcomes in this ...
Benito-León J - - 2013
BACKGROUND AND PURPOSE: Studies of high body mass index (BMI) and cognition in the elderly have shown conflicting results. While some studies have shown a detrimental effect of high BMI on cognitive function, others have observed beneficial effects on cognition. Our aim was to assess cognitive function in a large ...
Mizumoto Kenji - - 2013
ABSTRACT: BACKGROUND: During the very early stage of the 2009 pandemic, mass chemoprophylaxis was implemented as part of containment measure. The purposes of the present study were to systematically review the retrospective studies that investigated the effectiveness of antiviral prophylaxis during the 2009 pandemic, and to explicitly estimate the effectiveness ...
Yang Zhen-Zhen - - 2013
A binary system consisting of polyethylene glycol (PEG, proton donor)/PEG-functionalized base with suitable basicity was developed for efficient flue-gas desulfurization (FGD) and can be regarded as an alternative approach to circumventing the energy penalty problem in the FGD process. High capacity for SO2 capture up to 4.88 mol of SO2/mol ...
Steele Christopher J - - 2013
Training during a sensitive period in development may have greater effects on brain structure and behavior than training later in life. Musicians are an excellent model for investigating sensitive periods because training starts early and can be quantified. Previous studies suggested that early training might be related to greater amounts ...
Pranzatelli Michael R - - 2013
ABSTRACT: BACKGROUND: B-cell dysregulation has been implicated but not fully characterized in pediatric opsoclonus-myoclonus syndrome (OMS), a neuroblastoma-associated neuroinflammatory disorder. OBJECTIVE: To assess the role of B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL), two critical B cell-modulating cytokines, as potential biomarkers of disease activity and treatment biomarkers in ...
Andrésdóttir G - - 2013
AIMS: Hydrogen sulphide levels are reduced in many disease states, including diabetes and end-stage renal disease. We aimed to determine whether urinary sulphate excretion, as a proxy for hydrogen sulphide, was associated with progression of diabetic nephropathy. METHODS: We conducted a post-hoc study of a prospective, randomized, controlled trial on ...
Chen Junying - - 2013
Redox-inactive metal ions play pivotal roles in regulating reactivities of high-valent metal-oxo species in a variety of enzymatic and chemical reactions. A mononuclear nonheme manganese(IV)-oxo complex bearing a pentadentate N5 ligand has been synthesized and used in the synthesis of a Mn(IV)-oxo complex binding scandium ions. The Mn(IV)-oxo complexes are ...
Caman Ozge Karadag - - 2013
INTRODUCTION: Hospitality sector employees constitute one of the key groups with respect to their secondhand tobacco smoke exposure at work. This study aimed to detect urinary cotinine and breath carbon monoxide (CO) levels among bar and restaurant employees in Ankara, as well as the employees' opinions on the new antitobacco ...
Gibson Roger C - - 2013
This study explored how locus of control (LOC), depression and quality of life (QOL) interplay in patients with sickle cell disease. One hundred and forty-three sickle cell clinic patients with consecutive clinic consultations completed the Multidimensional Health Locus of Control and Short Factor 36 (SF-36) scales as well as the ...
Adler N - - 2013
According to European legislation, an Environmental Risk Assessment (ERA) of veterinary medicinal products (VMPs) for dung fauna is required in the authorization process if the substance acts as a parasiticide for the treatment of pasture animals. In the past, however, the demonstration of the environmental safety of those VMPs for ...
Luciano Alberto Maria - - 2013
Oocytes isolated from cows of reproductive age with reduced antral follicle counts (AFC) have a diminished capacity of embryonic development, which may be related to alterations in the mechanism that directs the proper segregation of chromosomes. Since we demonstrated that progesterone receptor membrane component 1 (PGRMC1) is involved in chromosome ...
Road J D JD Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United - - 2013
Cross-correlation of neural discharges was used to investigate the connections between expiratory bulbospinal neurons (EBSNs) in the caudal medulla and expiratory motoneurons innervating thoracic and abdominal muscles in anesthetized cats. Peaks were seen in the cross-correlation histograms for around half of the EBSN-nerve pairs for the following: at T8, the ...
Gao Zhiqiang - - 2013
A simple and ultrasensitive label-free microRNA (miRNA) biosensor, based on hybridized miRNA-templated deposition of an insulating polymer film and electrochemical impedance spectroscopic detection, is described in this report. The biosensor is made of a monolayer of charge-neutral morpholino capture probes on an indium tin oxide (ITO)-coated glass slide. Upon hybridization, ...
Agarwal Garima - - 2013
ObjectiveTo evaluate optical rhinometry (ORM) using nasal provocation testing (NPT) as an objective tool to diagnose fungal allergic rhinitis (AR).Study DesignProspective.SettingTertiary academic center.MethodsWe prospectively enrolled healthy controls (HCs) and subjects with a clinical history of AR and positive skin prick test to Alternaria or Aspergillus antigens. Baseline measurements with an ...
Nadaraia-Hoke Shorena - - 2013
Retroviral Gag proteins direct virus particle assembly from the plasma membrane (PM). Phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P(2)] plays a role in PM targeting of several retroviral Gag proteins. Here we report that depletion of intracellular PI(4,5)P(2) and phosphatidylinositol-(3,4,5)-triphosphate [PI(3,4,5)P(3)] levels impaired Rous sarcoma virus (RSV) Gag PM localization. Gag mutants deficient in nuclear ...
Minami Tomoyuki - - 2013
OBJECTIVES: The purpose of this study was to evaluate the clinical outcomes of emergency surgery for acute type B aortic dissection with rupture and to compare results between open surgery and thoracic endovascular aortic repair (TEVAR). METHODS: Two hundred and ninety-four patients with acute type B aortic dissection were admitted ...
Bozzali M - - 2013
BACKGROUND: Brain disconnection plays a major role in determining cognitive disabilities in multiple sclerosis (MS). We recently developed a novel diffusion-weighted magnetic resonance imaging (DW-MRI) tractography approach, namely anatomical connectivitity mapping (ACM), that quantifies structural brain connectivity. OBJECTIVE: Use of ACM to assess structural connectivity modifications in MS brains and ...
Brubaker Matt D - - 2013
In this letter we report on the fabrication, device characteristics, and optical coupling of a two-nanowire device comprising GaN nanowires with light-emitting and photoconductive capabilities. Axial p-n junction GaN nanowires were grown by molecular beam epitaxy, transferred to a non-native substrate, and selectively contacted to form discrete optical source or ...
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