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Reddy B V Subba - - 2013
A novel method has been devised for the synthesis of 2,4,5-trisubstituted pyrrole derivatives through the coupling of α-diazoketones with β-enaminoketones and esters using 10 mol % of Cu(OTf)(2). A wide range of 2,3-disubstituted indole derivatives were also prepared from α-diazoketones and 2-aminoaryl or alkyl ketones. The synthetic versatility of this ...
Srednicka-Tober Dominika - - 2013
Very little is known about the effects of an organic or conventional diet on animal physiology and health. Here we report the effect of contrasting crop protection (with or without chemosynthetic pesticides) and fertilization (manure or mineral fertilizers) regimes on feed composition and growth and physiological parameters of rats. The ...
Leone M A - - 2013
This paper is meant to provide guidance to anyone wishing to write a neurological guideline for diagnosis or treatment, and is directed at the Scientist Panels and task forces of the European Federation of Neurological Societies (EFNS). It substitutes the previous guidance paper from 2004. It contains several new aspects: ...
Sanz-Ramos Patricia - - 2013
Aim: The influence of culture substrate stiffness (in the kPa range) on chondrocyte behaviour has been described. Here we describe the response to variations in substrate stiffness in a soft range (2-20 Pa), as it may play a role in understanding cartilage physiopathology. Methods: We developed a system for cell ...
Goodwin Laura L Centre for Psychiatry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, UK. - - 2013
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with unknown etiology. This is the first study to use a life course approach to examine premorbid risk markers for self-reported IBS in a UK birth cohort. Cohort study using the 1958 British birth cohort, which included 98.7% of births in ...
Calligaris David - - 2013
MALDI mass spectrometry imaging (MALDI MSI) is a rapidly growing method in biomedical research allowing molecular mapping of proteins on histological sections. The images can be analyzed in terms of spectral pattern to define regions of interest. However, the identification and the differential quantitative analysis of proteins require off line ...
Demaret Julie - - 2013
BACKGROUND: By measuring multiple parameters on a single-cell basis, flow cytometry is a potent tool to dissect the phenotypes and functions of cell subsets. However, because this technique may be time-consuming, particularly for intracellular staining, it could be problematic for its use in daily routine or in large cohorts. Recently, ...
Aguilar Andres - - 2013
Landscape alterations have dramatic impacts on the distribution of genetic variation within and among populations and understanding these effects can guide contemporary and future conservation strategies. We initiated a landscape-scale genetic study of the coastal tailed frog (Ascaphus truei) on commercial timberlands within the southern range of the species in ...
Wan Elaine E Division of Cardiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. - - 2013
Excessively increased peripheral vasoconstriction is a hallmark of heart failure (HF). Here, we show that in mice with systolic HF post-myocardial infarction, the myogenic tone of third-order mesenteric resistance vessels is increased, the vascular smooth muscle (VSM) membrane potential is depolarized by ~20 mV, and vessel wall intracellular [Ca(2+)] is ...
Boyle Brad - - 2013
ABSTRACT: BACKGROUND: The digitization of biodiversity data is leading to the widespread application of taxon names that are superfluous, ambiguous or incorrect, resulting in mismatched records and inflated species numbers. The ultimate consequences of misspelled names and bad taxonomy are erroneous scientific conclusions and faulty policy decisions. The lack of ...
Lu Xiaoyan - - 2013
Outbreaks of human adenovirus (HAdV) acute respiratory illness (ARI) have been well documented among civilians and unvaccinated military recruits. Among the 7 recognized HAdV species (A to G), species B (particularly serotypes 3, 7, 11, 14, and 21) and E (serotype 4) have more often been associated with epidemic ARI. ...
Lin Jhih-Fong - - 2013
Colloid TiO2 nanorods are used for solution processable poly(3-hexyl thiophene): TiO2 hybrid solar cell. The nanorods were covered by insulating ligand of oleic acid (OA) after sol-gel synthesis. Three more conducting pyridine type ligands: pyridine, 2,6-lutidine (Lut) and 4-tert-butylpyridine (tBP) were investigated respectively to replace OA. The power conversion efficiency ...
Munga Stephen - - 2013
ABSTRACT: BACKGROUND: Larval control is of paramount importance in the reduction of vector populations. Previous observations have suggested that, larvae of Anopheles gambiae s.l occur more often in small temporary habitats while other studies showed that long-lasting stable habitats are more productive than unstable habitats. In addition, the physical and ...
Madhavi Vijaya V Department of Microbiology and Immunology; University of Melbourne; Melbourne, VIC - - 2013
HIV-specific ADCC antibodies could play a role in providing protective immunity. We have developed a whole blood ADCC assay that measures NK cell activation in response to HIV peptide epitopes. These HIV peptide-specific ADCC responses are associated with escape from immune recognition and slower progression of HIV infection and represent ...
Xu Shengjie - - 2013
Flower-like gold nanoparticles (Au NPs)/reduced graphene oxide (RGO) composites were fabricated by a facile, one-pot, environmentally friendly method in the presence of regenerated silk fibroin (RSF). The influences of reaction time, temperature, and HAuCl4: RGO ratio on the morphology of Au NPs loaded on RGO sheets were discussed and a ...
Sohlenius-Sternbeck Anna-Karin - - 2013
Abstract 1. We applied the regression offset approach to predict rat in vivo intrinsic clearance (CL(int)) for 54 new chemical acid entities with high plasma protein binding values and low renal clearance (CL). The prediction success was correlated to volume of distribution (V(d)), molecular weight (Mw) and CL. 2. A ...
Nicholson Tiffany - - 2013
Omega 3 polyunsaturated fatty acids (n-3 PUFA) have long been studied for their health benefits. In particular, marine n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to possess cardiovascular protective qualities. However, there is conflicting evidence as to the mechanisms, effectiveness and doses required ...
Jia Fan - - 2013
Flaviviral NS2B is a required cofactor for NS3 serine protease activity and plays an important role in promoting functional NS2B-NS3 protease configuration and maintaining critical interactions with protease catalysis substrates. The residues D(80)DDG in West Nile virus (WNV) NS2B are important for protease activity. To investigate the effects of D(80)DDG ...
Talavera Juan-Osvaldo - - 2013
Abstract Objective: The most prevalent dyslipidemias in Mexico are low high density lipoprotein (HDL) and high triglycerides (TG) levels. Hypertriglyceridemia (HTG) has been considered an independent risk factor for cardiovascular disease (CVD). The aim of this study was to evaluate the efficacy of rosuvastatin (RSV) in reducing TG levels in ...
Georgaca Eugenie - - 2013
Background. Discourse analytic approaches to mental distress have been developed in the last two decades as part of the broader social constructionist movement in psychology. Aims. The paper reviews existing discourse analytic studies on issues pertaining to mental distress, aiming to identify strengths and gaps in the existing literature as ...
Müller Brigitte - - 2013
We studied the retinal rod pathway of Carollia perspicillata and Glossophaga soricina, frugivorous microbats of the phyllostomid family. Protein kinase Cα (PKCα) immunolabeling revealed abundant rod bipolar cells (RBCs) with axon terminals in the innermost sublamina of the inner plexiform layer (IPL), which is typical for mammals. Extraordinarily, the RBC ...
Douville Christopher - - 2013
SUMMARY: Advances in sequencing technology have greatly reduced the costs incurred in collecting raw sequencing data. Academic laboratories and researchers therefore now have access to very large datasets of genomic alterations but limited time and computational resources to analyze their potential biological importance. Here, we provide a web-based application, Cancer-Related ...
Haering Felix - - 2013
We use non-close packed colloidal lithography to prepare hexagonal magnetic antidot arrays with varying diameters at a period of 205 nm. Smaller antidots are attractive for applications as spin waveguides in magnonics. Larger antidots form a magnetically frustrated system, i.e. Kagome spin-ice, as we prove by magnetic force microscopy. The simple but ...
Mendez Mario F MF Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, - - 2013
To characterize the presenting symptoms and signs of patients clinically diagnosed with behavioral variant frontotemporal dementia (bvFTD) and who had different neuropathologic findings on autopsy. This study reviewed all patients entered as clinical bvFTD in the National Alzheimer's Coordinating Center's database and who had both clinical and neuropathologic data from ...
Ding B Belinda BB Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, - - 2013
After undergoing Ig somatic hypermutation and Ag selection, germinal center (GC) B cells terminally differentiate into either memory or plasma cells (PCs). It is known that the CD40L and IL-21/STAT3 signaling pathways play critical roles in this process, yet it is unclear how the B cell transcription program interprets and ...
Higgins Matthew F - - 2013
Abstract Ten healthy, non-cycling trained males (age: 21.2 ± 2.2 years, body mass: 75.9 ± 13.4 kg, height: 178 ± 6 cm, [Vdot]O(2PEAK): 46 ± 10 ml · kg(-1) · min(-1)) performed a graded incremental exercise test, two familiarisation trials and six experimental trials. Experimental trials consisted of cycling to volitional exhaustion at 100%, 110% and 120% W(PEAK), 60 min after ingesting either 0.3 g · kg(-1) body mass ...
Gonder-Frederick L A - - 2013
AIMS: The Hypoglycemia Fear Survey (HFS)-II Behaviour and Worry subscales were developed to measure behaviours and anxiety related to hypoglycaemia in diabetes. However, previous studies found lower reliability in the HFS Behaviour subscale and inconsistent relationships with glucose control. The purpose of this study was to conduct extensive analyses of ...
Ashkenazi Avraham - - 2013
Modulation of T-cell responses by human immunodeficiency virus (HIV) occurs via distinct mechanisms, one of which involves inactivation of T cells already at the stage of virus-cell fusion. Hydrophobic portions of the gp41 protein of the viral envelope that contributes to membrane fusion may modulate T-cell responsiveness. Here we found ...
Zhao Feng - - 2013
For an efficient folate-targeted delivery, while the interaction between the folate on the carriers and the folate receptor (FR) on the cells is necessary, the recovering and recycling of FR to maintain a high density level of FR on the cellular membrane is also important. Herein, we demonstrate a design ...
Kisseleva Tatiana - - 2013
Comment on: Kisseleva T, et al. Proc Natl Acad Sci USA 2012; 109:9448-53; PMID:22566629; http://dx.doi.org/10.1073/pnas.1201840109.
Rambharose Sanjeev - - 2013
Abstract This study identified and compared the buccal permeability properties of antiretroviral drugs, didanosine (ddI) and tenofovir (TNF), and the permeability effects of polymeric excipients - i.e. carboxymethylcellulose (CMC), sodium alginate (SA), polyacrylic acid (PAA) and polyethylene glycol (PEG) - as potential multifunctional excipients for buccal drug delivery. Permeation studies ...
Yu Jiandong J Department of Neurology and Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, - - 2013
Temporal lobe epilepsy is associated with loss of interneurons and inhibitory dysfunction in the dentate gyrus. While status epilepticus (SE) leads to changes in granule cell inhibition, whether dentate basket cells critical for regulating granule cell feedforward and feedback inhibition express tonic GABA currents (I(GABA)) and undergo changes in inhibition ...
Hollensen Anne Kruse - - 2013
MicroRNAs (miRNAs) are ubiquitous regulators of gene expression that contribute to almost any cellular process. Methods for managing of miRNA activity are attracting increasing attention in relation to diverse experimental and therapeutic applications. DNA-encoded miRNA inhibitors expressed from plasmid or virus-based vectors provide persistent miRNA suppression and options of tissue-directed ...
Kullman E L EL Cleveland Clinic, Pathobiology, Cleveland, OH 44195, - - 2013
Aging may alter protein metabolism during periods of metabolic and physiologic challenge. The purpose of this study was to assess the effects of age on whole-body amino acid turnover in response to eccentric exercise and hyperglycemia-induced hyperinsulinemia. 16 healthy men were divided into young (N=8) and older (N=8) groups. Protein ...
Zhou Jianjun - - 2013
ABSTRACT: BACKGROUND: Structure-based clustering is commonly used to identify correct protein folds among candidate folds (also called decoys) generated by protein structure prediction programs. However, traditional clustering methods exhibit a poor runtime performance on large decoy sets. We hypothesized that a more efficient "partial" clustering approach in combination with an ...
Miao Wangen - - 2013
A dual-functional metallogel, which was based on the copper(II) complex of quinolinol-substituted L-glutamide, showed both redox-responsive and enantioselective properties; moreover, the metallogels collapsed into a sol after reduction and could be revived upon subsequent oxidation. The supramolecular chirality and morphology also reversible changed with the gel-sol transition. Furthermore, the metallogels ...
Duan Cuifang - - 2013
ABSTRACT: BACKGROUND: Rubber tree (Hevea brasiliensis) laticifers are the source of natural rubber. Rubber production depends on endogenous and exogenous ethylene (ethephon). AP2/ERF transcription factors, and especially Ethylene-Response Factors, play a crucial role in plant development and response to biotic and abiotic stresses. This study set out to sequence transcript ...
Bhattacherjee Aritra - - 2013
Peripheral axons are structurally plastic even in the adult, and altered axon density is implicated in many disorders and pain syndromes. However, mechanisms responsible for peripheral axon remodeling are poorly understood. Physiological plasticity is characteristic of the female reproductive tract: vaginal sensory innervation density is low under high estrogen conditions, ...
Dorr Michael - - 2013
The fundamental role of the visual system is to guide behavior in natural environments. To optimize information transmission, many animals have evolved a non-homogeneous retina and serially sample visual scenes by saccadic eye movements. Such eye movements, however, introduce high-speed retinal motion and decouple external and internal reference frames. Until ...
Geng Qiang - - 2013
The combination of fenofibrate with statins is a beneficial therapeutic option for patients with mixed dyslipidaemia, but concerns about adverse events make physicians reluctant to use this combined therapy. Medline, Embase and the Cochrane Library were searched to identify 13 randomized controlled trials (RCT) studies, involving 7712 patients, of statin-fenofibrate ...
Maini Surita - - 2013
In this article, new interstitial antenna operating at a frequency of 2.45 GHz for the treatment of hepatocellular carcinoma (HCC) using microwave ablation has been investigated. This antenna is basically an asymmetrical miniaturized choke dipole antenna with a pointed needle at the tip. A commercial finite element method (FEM) package, COMSOL ...
Lin Mouhong - - 2013
Multiwalled carbon nanotubes (MWCNT) were homogeneously covered with a bio-functional polydopamine (PDOP) by a simple dip-coating approach in mild basic solution. Then, uniformly dispersed and highly loaded platinum nanoparticles (PtNPs) were deposited on MWCNT@PDOP by a mild reductant, and were characterized by transmission electron microscopy and x-ray photoelectron spectroscopy. Afterwards, ...
Xu Dan - - 2013
PURPOSE: The proposed method is aimed at reducing eddy current (EC) induced distortion in diffusion weighted echo planar imaging, without the need to perform further image coregistration between diffusion weighted and T2 images. These ECs typically have significant high order spatial components that cannot be compensated by preemphasis. THEORY AND ...
Liao Ningbo - - 2013
The fresh water clam Corbicula fluminea is currently one of the most economically important aquatic species in China because of its nutritional value and pharmacological activity. In order to explore the potential of C. fluminea as a natural resource of bioactive compounds, a papain-released polysaccharide designated CFPS-2 was isolated. Chemical ...
Jung In Hye IH Postgraduate School of National Core Research Center for Nanomedical Technology, Seoul, - - 2013
Ongoing characterization of glioma has revealed that Akt signaling plays a crucial role in gliomagenesis. In mouse models, however, Akt alone was not sufficient to induce glioma. We established transgenic zebrafish that overexpressed dominant-active (DA) human Akt1 or Rac1(G12V) (DARac1) at ptf1a domain and investigated transgenic phenotypes and mechanisms leading ...
Mallikarjuna Reddy Guda - - 2013
A new class of mono- and bis-heterocycles, 2-arylsulfonylaminosulfonylmethyl-5-styrylsulfonylmethyloxadiazoles, pyrazolyl oxadiazoles, and isoxazolyl oxadiazoles, were synthesized and tested for their antioxidant activity. The styrylsulfonylmethyloxadiazole 5b showed good antioxidant activity when compared with the standard ascorbic acid.
Koh Peng Soon - - 2013
Adult choledochal or biliary cysts, thought to arise due to abnormalities in the pancreatico-biliary junction, are not uncommon, particularly in Asia.(1) Clinical presentation of choledochal cysts vary from being asymptomatic to jaundice development, an abdominal mass or even cholangitis and pancreatitis.(2) It is also associated with an increased risk of ...
Saisho Y - - 2013
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of oral hypoglycaemic agents that enhance endogenous incretin action by inhibiting its degradation enzyme DPP-4. DPP-4 inhibitors increase insulin secretion and suppress glucagon secretion in a glucose-dependent manner and clinical trials have shown that they are associated with a lower rate of ...
Carruthers Isaac M IM Dept. of Otorhinolaryngology and Head and Neck Surgery, Univ. of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, - - 2013
One of the central tasks of the mammalian auditory system is to represent information about acoustic communicative signals, such as vocalizations. However, the neuronal computations underlying vocalization encoding in the central auditory system are poorly understood. To learn how the rat auditory cortex encodes information about conspecific vocalizations, we presented ...
Kim Dae Wook - - 2013
Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) is a key enzyme that plays an important role in SARS virus replication. The ethanol extract of the seeds of Psoralea corylifolia showed high activity against the SARS-CoV PLpro with an IC(50) of value of 15 µg/ml. Due to its potency, ...
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