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Results 601 - 650 of 3031
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Pauwels Ine - - 2013
BACKGROUND: Recent studies suggest an association between rare variants in Mediterranean fever (MEFV), the gene underlying the auto-inflammatory disorder Familial Mediterranean Fever (FMF), the risk to develop multiple sclerosis (MS) and severity of MS. OBJECTIVE: The objective of this study is to investigate these findings in a Belgian MS population ...
Son Hyun-Soo - - 2013
Despite the antitumour effect of ursolic acid observed in several cancers, the underlying mechanism remains unclear. Thus, in the present study, the roles of AMP-activated protein kinase (AMPK) and glycogen synthase kinase 3 beta (GSK3β) were examined in ursolic acid induced apoptosis in HepG2 hepatocellular carcinoma cells. Ursolic acid significantly ...
Ian Ka Wa - - 2013
We report a new and simple low temperature soft reflow process using solvent vapour. The combination of this soft reflow and conventional i-line lithography enables low cost, highly efficient fabrication at the deep-submicron scale. Compared to the conventional thermal reflow process, the key benefits of the new soft reflow process ...
Jane Esther P EP Department of Neurosurgery, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, - - 2013
Antiapoptotic proteins are commonly overexpressed in gliomas, contributing to therapeutic resistance. We recently reported that clinically achievable concentrations of the Bcl-2/Bcl-xL inhibitor ABT-737 failed to induce apoptosis in glioma cells, with persistent expression of survivin and Mcl-1. To address the role of these mediators in glioma apoptosis resistance, we analyzed ...
Lebovitz H E - - 2013
BACKGROUND: Non-stimulatory, meal-mediated electrical stimulation of the stomach (TANTALUS-DIAMOND) improves glycaemic control and causes modest weight loss in patients with Type 2 diabetes who are inadequately controlled on oral anti-diabetic medications. The magnitude of the glycaemic response in clinical studies has been variable. A preliminary analysis of data from patients who ...
Yu Yejin - - 2013
Abstract 1. Organic anion transporting polypeptides (OATPs) are a family of transporter proteins that have been extensively recognized as key determinants of absorption, distribution, metabolism and excretion of various drugs. Human OATP1A2 has been demonstrated to transport wide spectrum of endogenous and exogenous compounds. Study on OATP1A2 orthologues of other ...
Zhang Yong-Wei - - 2013
We study the self-assembly of ordered nanostructures, i.e., nanorings (NRs), quantum dots (QDs), epitaxially grown on a polygonal cross-section nanowire (PCS-NW) using both theoretical and phase-field modeling. Our studies show that by increasing the PCS-NW size, transitions from ordered NRs, to ordered QDs on facets, and further to ordered QDs ...
Michaels Patrick J - - 2013
Background: For persons with mental illness, stigma diminishes employment and independent living opportunities as well as participation in psychiatric care. Public stigma interventions have sought to ameliorate these consequences. Aims: Evaluation of anti-stigma programs' impact is typically accomplished with self-report questionnaires. However, cultural mores encourage endorsement of answers that are ...
Takemura Taichiro - - 2013
Human immunodeficiency virus type 1 (HIV-1) infection of most human cells is dependent on cyclophilin A (CypA); however, the opposite phenomenon, known as CypA-dependent inhibition, is also observed in the combination of some capsid (CA) mutations and cell lines. Here, we identified a CA N121K mutant whose infection of 293T, ...
Parey Kristian - - 2013
Sulfate-reducing bacteria and archaea are important players in the biogeochemical sulfur cycle. ATP sulfurylase, adenosine 5'-phosphosulfate reductase and dissimilatory sulfite reductase are the key enzymes in the energy conserving process of SO(4)(2-) → H(2)S reduction. This review summarizes recent advances in our understanding of the activation of sulfate to adenosine ...
Goretti Emeline - - 2013
The capacity of EPCs to repair injured tissues is limited. The role of miRNAs in EPCs is largely unknown. We tested whether miRNAs may be useful to enhance the regenerative capacity of EPCs. Early EPCs were isolated from human PBMCs, and late EPCs were amplified from enriched human peripheral CD34(+) ...
Butler Trent Andrew - - 2013
The degree of phosphorylation of Myosin Light Chain 20 (MLC20) is a major determinant of force generation in smooth muscle. Myosin phosphatases (MP) all contain Protein Phosphatase 1 as catalytic subunits and are the major enzymes that dephosphorylate MLC20. MYPT1, the main regulatory subunit of MP in all smooth muscles, ...
Krueger Darcy A DA Department of Pediatrics and Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, - - 2013
To report long-term efficacy and safety data for everolimus for the treatment of subependymal giant cell astrocytoma (SEGA) in patients with tuberous sclerosis complex (TSC). This was an open-label extension phase of a prospective, phase 1-2 trial (NCT00411619) in patients ≥3 years of age with SEGA associated with TSC. Patients ...
Melen Rebecca L - - 2013
Reaction of Ph(2)C[double bond, length as m-dash]O and py(2)C[double bond, length as m-dash]O with Li[N(SiMe(3))(2)] and ArSCl (Ar = 2-O(2)NC(6)H(4), 2,4-(O(2)N)(2)C(6)H(3)) yielded Ph(2)C[double bond, length as m-dash]NSAr ( and respectively) and py(2)C[double bond, length as m-dash]NSAr ( and respectively). Reaction of fluorenone, C(12)H(8)C[double bond, length as m-dash]O with Li[N(SiMe(3))(2)] and ...
Zhang Liang - - 2013
Rapid boosting of memory CD8(+) T cells (T(M)) is essential in cancer immunotherapy and the control of certain infectious diseases. However, effector T cells (T(E)) are a barrier to booster vaccination because they can rapidly kill antigen-bearing APCs before T(M) are engaged. We demonstrate that viral-vectored vaccines delivered by B ...
Boilève Alice A INSERM, U848, Villejuif, - - 2013
Circumstantial evidence suggests that colon carcinogenesis can ensue the transient tetraploidization of (pre-)malignant cells. In line with this notion, the tumor suppressors APC and TP53, both of which are frequently inactivated in colon cancer, inhibit tetraploidization in vitro and in vivo. Here, we show that-contrarily to their wild-type counterparts- Tp53 ...
Mi Kim Sun - - 2013
INTRODUCTION: Characterizing the morphologies of occluded artery segments may help elucidate the etiology of chronic intracranial artery occlusion. We acquired high-resolution MRI (HR-MRI) of the middle cerebral artery (MCA) in patients with chronic unilateral MCA occlusion and evaluated the MRI and clinical findings. METHODS: We selected 20 consecutive patients who ...
Toufekoula Chryssoula - - 2013
ABSTRACT: Introduction Recent evidence suggests a link between excess lipid peroxidation and specific organ failures in sepsis. No study has ever been performed in sepsis by multidrug-resistant (MDR) Gram-negative bacteria. Methods Lethal sepsis was induced in rats by the intraperitoneal injection of one MDR isolate of Pseudomonas aeruginosa. Produced malondialdehyde ...
Lüsebrink Ulrich - - 2013
AIMS: Implantable cardioverter defibrillators (ICDs) have shown to reduce all-cause mortality in heart failure patients. In SCD-HeFT study, ICDs were programmed with a detection zone of ≥187 b.p.m. Thus, the incidence and clinical significance of slower ventricular tachycardias (VTs) in these patients remains largely unknown, though clinically important for device ...
Kung Ya-Hsin YH Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of - - 2013
We sought to evaluate the effects of intraoperative adjunctive autologous serum in idiopathic full-thickness macular hole surgeries, and to compare the surgical outcomes with a no-serum control group. In this retrospective, case-control study, 38 consecutive eyes received vitrectomy with internal limiting membrane removal for idiopathic full-thickness macular holes. Two groups ...
Smith David F - - 2013
ObjectiveAdenotonsillectomy (TA), performed for obstructive sleep apnea (OSA) or recurrent tonsillitis (RT), has been associated with weight gain after surgery. The objective of this study was to look at a large population of children undergoing TA and the demographic factors that contribute to postoperative weight gain.Study DesignCase series with retrospective ...
Hueffer Karsten - - 2013
ABSTRACT: BACKGROUND: Brucella is a group of bacteria that causes brucellosis, which can affect population health and reproductive success in many marine mammals. We investigated the serological prevalence of antibodies against Brucella bacteria in a declining harbor seal population in Glacier Bay National Park, Alaska. RESULTS: Prevalence ranged from 16 ...
Guo Yanan - - 2013
We report a novel phase separation phenomenon observed in the growth of ternary InxGa1-xAs nanowires by metalorganic chemical vapor deposition. A spontaneous formation of core-shell nanowires is investigated by cross-sectional transmission electron microscopy, revealing the compositional complexity within the ternary nanowires. It has been found that, for InxGa1-xAs nanowires, high ...
Hayes Catherine L CL Research School of Biology, Australian National University, Canberra, Australia Capital Territory, Australia. - - 2013
Theory suggests that reproductive effort generally increases with age, but life-history models indicate that other outcomes are possible. Empirical data are needed to quantify variation in actual age-dependence. Data are readily attainable for females (e.g. clutch per egg size), but not for males (e.g. courtship effort). To quantify male effort ...
Barbaro Michela - - 2013
ABSTRACT: Variegate porphyria (VP) is an autosomal dominantly inherited hepatic porphyria. The genetic defect in the PPOX gene leads to a partial defect of protoporphyrinogen oxidase, the penultimate enzyme of heme biosynthesis. Affected individuals can develop cutaneous symptoms in sun-exposed areas of the skin and/or neuropsychiatric acute attacks. The identification ...
Mihalopoulos Cathrine C Deakin Health Economics, Population Health Strategic Research Cluster, Deakin University, Melbourne, Victoria, Australia. - - 2013
Economic evaluation of individual interventions can have limited usefulness due to the potential for methodological confounding, particularly for those decision contexts where strategies involving multiple interventions are required. To introduce readers to different approaches of priority-setting, with a focus on economics-based examples of priority-setting in mental health. A selective review ...
Bifulco Giuseppe - - 2013
Quantum chemical calculations of one-bond carbon-carbon coupling constants are demonstrated as potential probes for the configurational assignment of organic molecules. The stereochemical analysis of strychnine and its possible stereoisomers is presented as proof of concept.
Obara Keisuke K Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, - - 2013
Very long-chain fatty acids (VLCFAs), fatty acids with chain-length greater than 20 carbons, possess a wide range of biological functions. However, their roles at the molecular level remain largely unknown. In the present study, we screened for multicopy suppressors that rescued temperature-sensitive growth of VLCFA-limited yeast cells, and we identified ...
Jin Shangbin - - 2013
Light works: Mechanistic insights into the photochemical events and charge dynamics of a donor-acceptor covalent organic framework were given by time-resolved transient absorption spectroscopy and time-resolved electron spin resonance spectroscopy. The organic framework triggers ultrafast electron transfer and enables long-distance charge delocalization and exceptional long-term charge separation.
Sivey John D - - 2013
HOBr, formed via oxidation of bromide by free available chlorine (FAC), is frequently assumed to be the sole species responsible for generating brominated disinfection byproducts (DBPs). Our studies reveal that BrCl, Br(2), BrOCl, and Br(2)O can also serve as brominating agents of the herbicide dimethenamid in solutions of bromide to ...
Nmor Jephtha C - - 2013
ABSTRACT: BACKGROUND: Identification of malaria vector breeding sites can enhance control activities. Although associations between malaria vector breeding sites and topography are well recognized, practical models that predict breeding sites from topographic information are lacking. We used topographic variables derived from remotely sensed Digital Elevation Models (DEMs) to model the ...
Smith Ursula E - - 2013
Despite being the objects of numerous macroevolutionary studies, many of the best-represented constituents of the fossil record-including diverse examples such as foraminifera, brachiopods, and mollusks-have mineralized skeletons with limited discrete characteristics, making morphological phylogenies difficult to construct. In contrast to their paucity of phylogenetic characters, the mineralized structures (tests and ...
Sallustio Fabio - - 2013
Acute kidney injury (AKI) is emerging as a worldwide public health problem. Recent studies have focused on the possibility of using human adult renal stem/progenitor cells (ARPCs) to improve the repair of AKI. Here we studied the influence of ARPCs on the healing of cisplatin-injured renal proximal tubular epithelial cells. ...
Hatakeyama Hiroyasu - - 2013
Tbc1d1 is key to skeletal muscle GLUT4 regulation. Herein, employing GLUT4 nanometry combined with a cell-based reconstitution model, we revealed a regulatory mode shift of Tbc1d1, by showing that Tbc1d1 temporally acquires insulin-responsiveness which triggers GLUT4 trafficking only after exercise-mimetic stimuli such as AICAR-pretreatment. The functional acquisition of insulin-responsiveness requires ...
Beauregard Arthur - - 2013
Yersinia pestis, the etiologic agent of plague, is closely related to Yersinia pseudotuberculosis evolutionarily but has a very different mode of infection. The RNA-binding regulatory protein, Hfq, mediates regulation by small RNAs (sRNAs) and is required for virulence of both Y. pestis and Y. pseudotuberculosis. Moreover, Hfq is required for ...
Aoki-Kinoshita Kiyoko F KF Department of Bioinformatics, Faculty of Engineering, Soka University, 1-236 Tangi-machi, Hachioji, Tokyo, Japan. - - 2013
Many databases of carbohydrate structures and related information can be found on the World Wide Web. This review covers the major carbohydrate databases that have potential utility for glycoscientists and researchers entering the glycosciences. The first half provides a brief overview of carbohydrate databases and web resources (including a history ...
Guttman-Yassky Emma - - 2013
Introduction: Atopic dermatitis (AD) is a common inflammatory skin disease regulated by genetic and environmental factors. Both skin barrier defects and aberrant immune responses are believed to drive cutaneous inflammation in AD. Existing therapies rely largely on allergen avoidance, emollients and topical and systemic immune-suppressants, some with significant toxicity and ...
Kelly Ciarán P - - 2013
In 1958, doctors in Denver administered feces by enema to their patients with fulminant, life-threatening pseudomembranous enterocolitis.(1) The goal of this infusion of donor feces (also termed fecal microbiota transplantation [FMT]) was to "re-establish the balance of nature" within the intestinal flora to correct the disruption caused by antibiotic treatment. ...
Di Motta Simone - - 2013
The photophysical properties of a multicomponent [1]rotaxane bearing a β-cyclodextrin ring covalently connected to an axle comprising an azobenzene photoisomerisable moiety and a naphthalimide-type fluorescent stopper are investigated by a combined experimental and computational study. The absorption and fluorescence spectra, and particularly the induced circular dichroism (ICD) signal, are determined. ...
Li Jingfa - - 2013
Binary metal oxides have been regarded as ideal and potential anode materials, which can ameliorate and offset the electrochemical performance of the single metal oxides, such as reversible capacity, structural stability and electronic conductivity. In this work, monodisperse NiCo(2)O(4) mesoporous microspheres are fabricated by a facile solvothermal method followed by ...
Gmitrov Juraj - - 2013
We compared in conscious rabbits, sedated using pentobarbital intravenous (i.v.) infusion (5 mg kg(- 1) h(- 1)), the effect of a static magnetic field (SMF), generated by Nd(2)-Fe(14)-B magnets, on microcirculation during its 40 min local exposure to the microvascular network in cutaneous tissue [20 sham exposure and 20 SMF (0.25 T) exposure runs] or to sinocarotid ...
Hanai Toshihiko - - 2013
Retention times in reversed-phase liquid chromatography were quantitatively analyzed in silico using alkanes as standard compounds, much like they have been used for Kovats indices in gas chromatography. The molecular interaction energy was calculated between an analyte and a model hydrophobic phase using a molecular mechanics program. The solvation energy ...
Akimoto Takayuki - - 2013
Mammalian skeletal muscles undergo adaptation in response to changes in the functional demands upon them, involving mechanical-stress-induced cellular signaling called "mechanotransduction". We hypothesized that p130Cas, which is reported to act as a mechanosensor that transduces mechanical extension into cellular signaling, plays an important role in maintaining and promoting skeletal muscle ...
Leri Francesco - - 2013
It has been proposed that the reinforcing properties of drugs of abuse are due, in part, to their ability to enhance memory consolidation. To test this hypothesis, heroin (0.03-3 mg/kg, SC) and d-amphetamine (0.5-2 mg/kg, SC) were administered to male Sprague-Dawley rats immediately or 4 h after training on win-stay ...
Lahtela Jenni - - 2013
Activation of a cellular senescence program is a common response to prolonged oncogene activation or tumor suppressor loss, providing a physiological mechanism for tumor suppression in premalignant cells. The link between senescence and tumor suppression supports the hypothesis that a loss-of-function screen measuring bona fide senescence marker activation should identify ...
Knell Jamie J Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, - - 2013
CD8(+) T cells play a crucial role in the clearance of intracellular pathogens through the generation of cytotoxic effector cells that eliminate infected cells and long-lived memory cells that provide enhanced protection against reinfection. We have previously shown that the inhibitor of E protein transcription factors, Id2, is necessary for ...
Martino Ashley T AT Department of Pharmaceutical Sciences, St. John's University, Queens, NY, - - 2013
Recent clinical trials have shown that evasion of CD8(+) T-cell responses against viral capsid is critical for successful liver-directed gene therapy with adeno-associated viral (AAV) vectors for hemophilia. Preclinical models to test whether use of alternate serotypes or capsid variants could avoid this deleterious response have been lacking. Here, the ...
Hayashi Masamichi J MJ Institute of Biomedicine, Physiology, University of Helsinki, Helsinki 00014, Finland. - - 2013
It has been proposed that numerical and temporal information are processed by partially overlapping magnitude systems. Interactions across different magnitude domains could occur both at the level of perception and decision-making. However, their neural correlates have been elusive. Here, using functional magnetic resonance imaging in humans, we show that the ...
Gannon Anne Marie - - 2013
Cigarette smoking is a lifestyle behavior associated with significant adverse health effects including subfertility and premature ovarian failure. Cigarette smoke contains a number of chemicals, many of which are involved in the generation of reactive oxygen species, which can lead to apoptosis and autophagy. Autophagy is a fundamental process that ...
Scangos Katherine W KW Department of Neuroscience, Johns Hopkins University School of Medicine and Zanvyl Krieger Mind/Brain Institute, Baltimore, MD, - - 2013
A key component of executive control and decision making is the ability to use the consequences of chosen actions to update and inform the process of future action selection. Evaluative signals, which monitor the outcomes of actions, are critical for this ability. Signals related to the evaluation of actions have ...
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