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Byrd H C M - - 2013
What is already known about this subject Youth with ADHD may be at increased risk for obesity. Medications used to treat ADHD can affect weight. Few studies have investigated possible gender differences in associations between ADHD and obesity. What this study adds Nationally representative of US youth aged 8-15 years. Height ...
Hooper Joel F - - 2013
A new functional-group tolerant, rhodium-catalyzed, sulfide-reduction process is combined with rhodium-catalyzed chelation-controlled hydroacylation reactions to give a traceless hydroacylation protocol. Aryl- and alkenyl aldehydes can be combined with both alkenes, alkynes and allenes to give traceless products in high yields. A preliminary mechanistic proposal is also presented.
Miche Martina - - 2013
Objectives.The subjective experience of aging is a relevant correlate of developmental outcomes. However, traditional approaches fall short of capturing the inherent multidimensionality of subjective aging experiences (SAEs). Based on the concept of Awareness of Age-Related Change (AARC; Diehl, M. K., & Wahl, H.-W. (2010). Awareness of age-related change: Examination of ...
Hidalgo Isabel - - 2013
Comment on: Hidalgo I, et al. Cell Stem Cell 2012; 11:649-62.
Goel Anubhuti A Dept. of Neurobiology and Psychology, Integrative Center for Learning and Memory, Univ. of California, Los Angeles, Los Angeles, CA 90095, - - 2013
Neural dynamics generated within cortical networks play a fundamental role in brain function. However, the learning rules that allow recurrent networks to generate functional dynamic regimes, and the degree to which these regimes are themselves plastic, are not known. In this study we examined plasticity of network dynamics in cortical ...
Greally Elizabeth - - 2013
ABSTRACT: BACKGROUND: Manganese-enhanced cardiovascular magnetic resonance (MECMR) can non-invasively assess myocardial calcium influx, and calcium levels are known to be elevated in muscular dystrophy cardiomyopathy based on cellular studies. METHODS: Left ventricular functional studies and MECMR were performed in mdx mice (model of Duchenne Muscular Dystrophy, 24 and 40 weeks) ...
Zenner D - - 2013
SUMMARY Societal and technological changes render traditional study designs less feasible for investigation of outbreaks. We compared results obtained from case-case and case-control designs during the investigation of a Salmonella Enteritidis PT14b (SE14b) outbreak in Britain to provide support for validation of this approach. Exposures of cases were compared to ...
Tocchetti Carlo G - - 2013
Left ventricular dysfunction from anticancer drugs has emerged as a relevant problem in the clinical and scientific communities. Anthracycline toxicity has always been the most relevant, but with the increasing use of biological targeted therapies in treatment protocols, with an increasing number of cancer survivors, new toxicities have been increasing ...
Dos Santos K B - - 2013
This study aimed to determine whether: i) tethe-red-swimming can be used to identify the asymmetry during front crawl swimming style; ii) swimmers that perform unilateral breathing present greater asymmetry in comparison to others that use bilateral breathing; iii) swimmers of best performance present smaller asymmetry than their counterparts; iv) repeated ...
Matsuno Keita - - 2013
Bhanja virus (BHAV) and its antigenically close relatives Forecariah virus (FORV), Kismayo virus (KISV), and Palma virus (PALV) are thought to be members of the family Bunyaviridae, but they have not been assigned to a genus or species. Despite their broad geographical distribution and reports that BHAV causes sporadic cases ...
Sorrentino Vincenzo - - 2013
AimsRecent genome-wide association studies suggest that IDOL (also known as MYLIP) contributes to variation in circulating levels of low-density lipoprotein cholesterol (LDL-C). IDOL, an E3-ubiquitin ligase, is a recently identified post-transcriptional regulator of LDLR abundance. Briefly, IDOL promotes degradation of the LDLR thereby limiting LDL uptake. Yet the exact role ...
Grigg Joseph W JW Department of Biology, University of North Carolina, Chapel Hill, NC 27599, - - 2013
Species may exhibit similar thermal tolerances via either common ancestry or environmental filtering and local adaptation, if the species inhabit similar environments. We ask whether upper and lower thermal limits (critical thermal maxima and minima) and body temperatures are more strongly conserved across evolutionary history or geography for lizard populations ...
Namiki Shigehiro - - 2013
Correlated spiking activity prevails in immature cortical networks and is believed to contribute to neuronal circuit maturation; however, its spatiotemporal organization is not fully understood. Using wide-field calcium imaging from acute whole-brain slices of rat pups on postnatal days 1-6, we found that correlated spikes were initiated in the anterior ...
Park Soo Hyun - - 2013
A focal stimulus triggers neural activity that spreads to cortical regions far beyond the stimulation site, creating a so-called "cortical point spread" (CPS). Animal studies found that V1 neurons possess lateral connections with neighboring neurons that prefer similar orientations and to neurons representing visuotopic regions that are constrained by their ...
Pootawang Panuphong - - 2013
In this study, we investigate a new synthetic route, termed the solution plasma process, for the synthesis of colloidal copper nanoparticles (CuNPs) in the presence of an amide and acid capping agent. Gelatin and ascorbic acid were selected as the capping agents to protect the particles against coalescence and oxidation ...
Dean Justin M JM Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, - - 2013
Children who survive preterm birth exhibit persistent unexplained disturbances in cerebral cortical growth with associated cognitive and learning disabilities. The mechanisms underlying these deficits remain elusive. We used ex vivo diffusion magnetic resonance imaging to demonstrate in a preterm large-animal model that cerebral ischemia impairs cortical growth and the normal ...
Desbois G - - 2013
The contribution describes the implementation of a broad ion beam (BIB) polisher into a scanning electron microscope (SEM) functioning at cryogenic temperature (cryo). The whole system (BIB-cryo-SEM) provides a first generation of a novel multibeam electron microscope that combines broad ion beam with cryogenic facilities in a conventional SEM to ...
Campanholle Gabriela G Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA, - - 2013
Chronic kidney disease, defined as loss of kidney function for more than three months, is characterized pathologically by glomerulosclerosis, interstitial fibrosis, tubular atrophy, peritubular capillary rarefaction, and inflammation. Recent studies have identified a previously poorly appreciated, yet extensive population of mesenchymal cells, called either pericytes when attached to peritubular capillaries ...
Romeiro Fernando Gomes - - 2013
ABSTRACT: BACKGROUND: Hepatic encephalopathy (HE) is a severe complication in patients with hepatic cirrhosis, which causes numerous hospital admissions and deaths. Antibiotics are the best options in HE treatment, but head-to-head comparisons between these drugs are scarce. Erythromycin combines the antimicrobial effect and prokinetic properties in the same drug, but ...
van Amsterdam Jan - - 2013
The aim of this paper is to create awareness of the negative health impact and economic burden and benefits associated to alcohol consumption. Worldwide about two billion people consume alcohol. Low intake of alcohol has a minor protective cardiovascular effect. On the other hand, even moderate alcohol consumption appears to ...
Caldon C Elizabeth CE The Kinghorn Cancer Centre and Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, - - 2013
Cyclins E1 drives the initiation of DNA replication, and deregulation of its periodic expression leads to mitotic delay associated with genomic instability. Since it is not known whether the closely related protein cyclin E2 shares these properties, we overexpressed cyclin E2 in breast cancer cells. This did not affect the ...
Deshpande Pratima P Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, - - 2013
Regulation of the ERK pathway is intimately involved in determining whether TCR stimulation is productive or induces anergy. T cells from patients with rheumatoid arthritis (RA) have increased ERK responsiveness, which may be relevant for disease pathogenesis. Inflammatory cytokines such as TNF-α did not reproduce the TCR hypersensitivity typical for ...
ten Hacken Elisa - - 2013
HS1 (hematopoietic cell-specific Lyn substrate-1) is a cytoskeletal interactor in the B-cell receptor (BCR) signaling pathway whose phosphorylation correlates with prognosis in Chronic Lymphocytic Leukemia (CLL). The differentially phosphorylated sites and the kinases that regulate HS1 activity in CLL remain poorly understood. We demonstrate that HS1 activity is differentially regulated ...
Fischer Ashley L - - 2013
Objectives. Age reductions in theory of mind (ToM) are well documented, though underlying mechanisms are poorly understood. Research suggests that traditional cognitive abilities underlie ToM in part; however, whether age-associated health modifiers also predict ToM remains unknown. We investigated the role of pulse pressure (PP), an age-related marker of vascular ...
Cho Gye Song - - 2013
Respiratory viral infections are often implicated as triggers of chronic rhinosinusitis (CRS) flare-ups. However, there is a paucity of respiratory viral surveillance studies in CRS patients, and such studies could elucidate the potential role of viruses in promoting symptoms and aggravating mucosal inflammation. Therefore, a prospective case-control study was conducted ...
Flegr Jaroslav - - 2013
ABSTRACT: : Punctuational theories of evolution suggest that adaptive evolution proceeds mostly, or even entirely, in the distinct periods of existence of a particular species. The mechanisms of this punctuated nature of evolution suggested by the various theories differ. Therefore the predictions of particular theories concerning various evolutionary phenomena also ...
Privman Vladimir - - 2013
We develop a framework for optimizing a novel approach to extending the linear range of bioanalytical systems and biosensors by utilizing two enzymes with different kinetic responses to the input chemical as their substrate. Data for the flow-injection amperometric system devised for detection of lysine based on the function of ...
Yang Ya - - 2013
In general, methyl orange (MO) can be degraded by an electrocatalytic oxidation process driven by a power source due to the generation of superoxidative hydroxyl radical on the anode. Here, we report a hybrid energy cell that is used for a self-powered electrocatalytic process for the degradation of MO without ...
Lindsay C J - - 2013
Objective: The aim of this paper is to bridge the gap between the corpus of imitation research and video-based intervention (VBI) research, and consider the impact imitation skills may be having on VBI outcomes and highlight potential areas for improving efficacy. Method: A review of the imitation literature was conducted ...
Chin E - - 2013
Four-dimensional volumetric modulated arc therapy (4D VMAT) is a treatment strategy for lung cancers that aims to exploit relative target and tissue motion to improve organ at risk (OAR) sparing. The algorithm incorporates the entire patient respiratory cycle using 4D CT data into the optimization process. Resulting treatment plans synchronize ...
Mayson T A - - 2013
Objectives: To assess "alternate forms" reliability and inter-rater reliability of Gross Motor Function Classification System (GMFCS) scores. Methods: Fifty randomly selected children with cerebral palsy were divided into two groups: (1) GMFCS score assigned during gait assessment ("GMFCS previously assigned") and (2) no GMFCS score assigned. Using database information, two ...
Cohen Raphael - - 2013
ABSTRACT: BACKGROUND: The increasing availability of Electronic Health Record (EHR) data and specifically free-text patient notes presents opportunities for phenotype extraction. Text-mining methods in particular can help disease modeling by mapping named-entities mentions to terminologies and clustering semantically related terms. EHR corpora, however, exhibit specific statistical and linguistic characteristics when ...
Wolf Gernot - - 2013
Endogenous retroviruses (ERVs) are remnants of retroviral germ line infections and have been identified in all mammals investigated so far. Although the majority of ERVs are degenerated, some mammalian species, such as mice and pigs, carry replication-competent ERVs capable of forming infectious viral particles. In mice, ERVs are silenced by ...
Magliulo Maria - - 2013
A Functional Bio-Interlayer Organic Field-Effect Transistor (FBI-OFET) sensor, embedding a streptavidin protein capturing layer, capable to perform label-free selective electronic detection of biotin at 3 part-per-trillion (mass fraction) or 15 pM, is here proposed. The response shows a logarithmic dependence spanning over five orders of magnitude of analyte concentration. The ...
Laas Kariina - - 2013
Neuropeptide S and its receptor NPSR1 are involved in the regulation of arousal, attention and anxiety. We examined whether the NPSR1 gene functional polymorphism Asn(107)Ile (rs324981, A>T) influences personality, impulsivity, and attention-deficit/hyperactivity disorder (ADHD)-related symptoms in a population-representative sample, and whether any eventual associations depend on age, sex, family relations ...
Sariyar M - - 2013
Introduction We present a framework for data management processes in population-based medical registries. Existing guidelines lack the concreteness we deem necessary for them to be of practical use, especially concerning the establishment of new registries. Therefore, we propose adjustments and concretisations with regard to data quality, data privacy, data security ...
Ramsay Alan G AG Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom. - - 2013
T lymphocytes have an essential role in adaptive immunity and rely on the activation of integrin lymphocyte function-associated antigen-1 (LFA-1) to mediate cell arrest and migration. In cancer, malignant cells modify the immune microenvironment to block effective host antitumor responses. We show for the first time that CD4 and CD8 ...
Xiang Jing - - 2013
The synthesis, crystal structures and magnetic properties of six cyano-bridged heterobimetallic compounds prepared from a paramagnetic Ru(III) building block, trans-(PPh(4))[Ru(III)(Q)(2)(CN)(2)] () (Q = the anion of 8-hydroxyquinoline), are described. reacts with hydrated MnCl(2) in MeOH or DMF to produce a trinuclear compound {[Ru(III)(Q)(2)(CN)(2)](2)[Mn(II)(MeOH)(4)]}·8MeOH (), or a 1-D zigzag chain {[Mn(II)(DMF)(2)(Cl)](μ-CN)(2)[Ru(III)(Q)(2)]}(n). ...
Rice Andrew P - - 2013
Comment on: Boehm D, et al. Cell Cycle 2013; 12(3): In press.
Turner-McGrievy Gabrielle G Dept. of Health Promotion, Education, and Behavior, The Univ. of South Carolina, 800 Sumter St., Suite 216, Columbia, SC 29208, USA. - - 2013
Results examining the effects of tasting profile on dietary intake and health outcomes have varied. This study examined the interaction of sweet liker (SL) and supertaster (ST) (bitter taste test through phenylthiocarbamide [PTC]) status with incidence of metabolic syndrome. Participants (n = 196) as part of baseline testing in a ...
Gladun Anatoly - - 2013
A large amount of biomedical and genomic data are currently available on the Internet. However, data are distributed into heterogeneous biological information sources, with little or even no organization. Semantic technologies provide a consistent and reliable basis with which to confront the challenges involved in the organization, manipulation and visualization ...
Munksgaard Niels C - - 2013
Measurement of soil-respired CO(2) at high temporal resolution and sample density is necessary to accurately identify sources and quantify effluxes of soil-respired CO(2). A portable sampling device for the analysis of δ(13)C values in the field is described herein. CO(2) accumulated in a soil chamber was batch sampled sequentially in ...
Zhu Ruixia - - 2013
Abstract Background: Numerous studies have reported variable associations between ambient particulate matter (PM) and chronic obstructive pulmonary disease (COPD) hospitalizations and mortality. Objective: To conduct a systematic study assessing the associations between hospitalizations and mortality from COPD and ambient PM(10) (particulate matter with aerodynamic diameters ≤ 10 μm, PM(10)). Methods: Systematic ...
Bruno Andrew E - - 2013
ABSTRACT: BACKGROUND: Gene fusions are the result of chromosomal aberrations and encode chimeric RNA (fusion transcripts) that play an important role in cancer genesis. Recent advances in high throughput transcriptome sequencing have given rise to computational methods for new fusion discovery. The ability to simulate fusion transcripts is essential for ...
Zhang Liwu - - 2013
Herein we report a facile and economic method to prepare nanovoid Bi(2) WO(6) 2D ordered arrays employing a simple self-assembly procedure. The electrochemical properties and performance of the 2D nanoarray as a photoanode for water splitting are investigated and compared with a conventional photoanode of similar thickness. The 2D array ...
Sawaki Naoya - - 2013
Nitrogen is the most important macronutrient in plants and its supply induces responses in gene expression, metabolism and developmental processes. However, the molecular mechanisms underlying the nitrogen responses remain poorly understood. Here we show that the supply of nitrate but not ammonium immediately induces the expression of a transcriptional repressor ...
Sun Binjie - - 2013
Erythropoietin (EPO) is an attractive protein-unfolding/folding model because of its high degree of unfolding & folding reversibility and intermediate size. Due to its function for regulating red blood cell production by stimulating late erythroid precursor cells, EPO presents obvious values to biological research. A nonemissive anthracene derivative, that is 9,10-bis[4-(3-sulfonatopropoxyl)-styryl]anthracene ...
Tan H K - - 2013
AIMS: To quantify the frequency of biochemical hypoglycaemia in acutely unwell patients in the medical assessment unit and relate this to their subsequent outcomes. METHODS: A retrospective audit was conducted on all emergency medical patients attending the medical assessment unit between November 2010 and April 2011. Capillary blood glucose measurements ...
Tang Xin X The Visual Systems Group, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, - - 2013
Temperature sensation has a strong impact on animal behavior and is necessary for animals to avoid exposure to harmful temperatures. It is now well known that thermoTRP (transient receptor potential) channels in thermosensory neurons detect a variable range of temperature stimuli. However, little is known about how a range of ...
Fox Philip D - - 2013
The Kv2.1 voltage-gated K(+) channel is found both freely diffusing over the plasma membrane and concentrated in micron-sized clusters localized to the soma, proximal dendrites, and axon initial segment of hippocampal neurons. In transfected HEK cells, Kv2.1 channels within cluster microdomains are nonconducting. Using total internal reflection fluorescence microscopy, the ...
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