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Dürr Sophie - - 2013
Mammalian IDO is a heme-containing enzyme whose main activity in mammals is to degrade the essential amino acid tryp into l-kynurenine. Although the link between its enzymatic activity and the immune response is not straightforward, several lines of evidence suggest that this enzyme is involved in fighting infections and paradoxically, ...
Guaita Massimo - - 2013
  The present work studied the effect of the kind of closure (a screw cap, a natural cork, and 2 synthetic closures) on the evolution of the oxygen content and on the physical-chemical and sensory characteristics of a Montepulciano d'Abruzzo rosé wine during the 1st 12 mo of bottle aging. ...
Nuhu Folorunsho Tajudeen - - 2013
Background: Cancer is associated with psychological and physical morbidities. The presence of such comorbidities has been reported to worsen the overall outcome and quality of life (QOL) of affected people. Aims: To assess the QOL and its determinants among participants with cancer. Methods: We administered the short version of the ...
Chen Chi - - 2013
Facile aqueous synthesis of near-infrared Ag2Te QDs and Ag2Te/ZnS core/shell QDs emitting in the second biological window is reported. The QD synthesis is based on a straightforward cation exchange process between CdTe QDs and Ag+ ions conducted in aqueous solution. The prepared Ag2Te QDs possess near-infrared emission ranging from 900 ...
Kandulski Arne - - 2013
ABSTRACT: BACKGROUND: Inadequate response to proton pump inhibitor (PPI) therapy in patients with gastroesophageal reflux disease (GERD) is reported in up to 40%. Patients with non erosive reflux disease (NERD) have lower response rates compared to patients with erosive reflux disease (ERD); pH metry contributes to GERD diagnosis and is ...
Yin Jingchuan - - 2013
Since the first human case of H5N1 avian influenza virus infection was reported in 1997, this highly pathogenic virus has infected hundreds of people around the world and resulted in many deaths. The ability of H5N1 to cross species boundaries, and the presence of polymorphisms that enhance virulence, present challenges ...
Bayman Emine O - - 2013
ABSTRACT: BACKGROUND: To quantify the variability among centers and to identify centers whose performance are potentially outside of normal variability in the primary outcome and to propose a guideline that they are outliers. METHODS: Novel statistical methodology using a Bayesian hierarchical model is used. Bayesian methods for estimation and outlier ...
Milham Samuel - - 2013
Dirty electricity, also called electrical pollution, is high-frequency voltage transients riding along the 50 or 60 Hz electricity provided by the electric utilities. It is generated by arcing, by sparking and by any device that interrupts current flow, especially switching power supplies. It has been associated with cancer, diabetes and attention ...
Tripathi Rati K P - - 2013
Monoamine oxidase B (MAO-B) is an important drug target for the treatment of neurological disorders. A series of 6-nitrobenzothiazole-derived semicarbazones were designed, synthesized, and evaluated as inhibitors of the rat brain MAO-B isoenzyme. Most of the compounds were found to be potent inhibitors of MAO-B, with IC(50) values in the nanomolar ...
Bell Simon - - 2013
Rotator cuff tears are a common clinical problem, and few long-term studies concerning the outcomes of rotator cuff repairs have been performed. The purpose of this study was to report the fifteen-year outcomes of arthroscopic subacromial decompression with mini-open rotator cuff repair. The study included seventy-nine patients who had undergone ...
Abrahamsen Bjarke - - 2013
In the present study, the mechanism of action and molecular basis for the activity of the first class of selective inhibitors of the human excitatory amino acid transporter subtype 1 (EAAT1) and its rodent ortholog GLAST are elucidated. The previously reported specificity of UCPH-101 and UCPH-102 for EAAT1 over EAAT2 ...
Prolla Ivo R D - - 2013
Cooked white rice (CWR) provides up to 71% of the dietary protein for many people worldwide. The protein digestibility-corrected amino acid (AA) score is the method adopted by FAO/WHO to evaluate protein quality. Our group has proposed the metabolic availability (MA) of AAs as another determinant of protein quality. It ...
Hill Elisabeth L - - 2013
Background Developmental coordination disorder (DCD) affects up to 6% of the population and is diagnosed on the basis of poor motor coordination. While we know rather little about its lifetime consequences, clear and significant difficulties remain through the lifespan for the majority. Reduced physical activity and, outside of the motor ...
Macphee Graeme J A - - 2013
Parkinson disease (PD) is now conceptualized as a neuropsychiatric disorder with characteristic motor features.(1) It is increasingly recognized that standard dopaminergic treatments, particularly dopamine agonist drugs, can trigger devastating impulse control behaviors (ICB) in patients with PD.(1-3) ICB encompass impulse control disorders (ICD) and related disorders such as dopamine dysregulation ...
Xue Meng - - 2013
Cytomegalovirus, regarded as a trigger of several autoimmune diseases, is an opportunistic pathogen and ulcerative colitis (UC) patients with steroids treatment are susceptible to this infection. At the presence of cytomegalovirus, the inflammation will become more complex and unresponsive to steriods. Active UC patients infected with cytomegalovirus are usually steroid ...
Ferrer Dubois Ae - - 2013
Antioxidant effects of tomatoes (Solanum lycopersicum L.) have been studied and an association between dietary intake of tomatoes and lowered risk of cancer, neurodegenerative, and cardiovascular diseases has been suggested. Here we used magnetically treated water (MTW; 0.03-0.15 T), which promotes better germination and productivity in tomatoes, and we investigated the ...
Morris Russell E - - 2013
No added solvent means no waste solvent or recycling costs. Understandably the chemical industry is interested in developing approaches to increase the product to solvent ratio in synthesis. In recent work various zeolites were prepared by grinding the dry materials and then heating to 180 °C, and this method could lead ...
Eriksson Jonas - - 2013
Past research on first sexual intercourse experiences and virginity has largely focused on using demographics such as age at first intercourse as predictors of future sexual behaviors and beliefs. Carpenter ( 2002 , 2005 ) suggested a model of three virginity metaphors that describe how individuals perceive their virginity: gift, ...
Osmonov D K - - 2013
Treatment of a biochemical prostate cancer relapse represents a difficult clinical dilemma, which has remained without a definitive solution so far. Based on clinical studies, we combine radical prostatectomy with extended pelvic lymph node dissection in intermediate and high risk patients as a routine procedure at our clinic. In this ...
Holder Thomas - - 2013
ABSTRACT: BACKGROUND: Alvinella pompejana is an annelid worm that inhabits deep-sea hydrothermal vent sites in the Pacific Ocean. Living at a depth of approximately 2500 meters, these worms experience extreme environmental conditions, including high temperature and pressure as well as high levels of sulfide and heavy metals. A. pompejana is ...
Okumu Fredros O - - 2013
ABSTRACT: BACKGROUND: Indoor residual insecticide spraying (IRS) and long-lasting insecticide treated nets (LLINs) are commonly used together even though evidence that such combinations confer greater protection against malaria than either method alone is inconsistent. METHODS: A deterministic model of mosquito life cycle processes was adapted to allow parameterization with results ...
Miller Holly C - - 2013
The consumption of glucose can enhance executive control by increasing blood glucose and providing energy for brain processes. However, a glucose mouth rinse also positively affects executive control in the absence of an effect on blood glucose. This observation suggests that glucose can enhance executive control via another mechanism, perhaps ...
Naismith Robert T - - 2013
Acute, noninfectious, inflammatory illnesses of the CNS encompass an increasingly diverse array of clinical and biological entities, including acute disseminated encephalomyelitis (ADEM), brainstem encephalitis, and paraneoplastic and nonneoplastic antibody-associated encephalopathies. ADEM is classically a monophasic, inflammatory-mediated attack on the CNS, more frequently seen in children than adults.(1) According to international ...
Cui Liang - - 2013
RNA probes constitute an important class of functional nucleic acids (FNAs). However, because of their notorious vulnerability to enzymatic degradation, extremely careful and special protocols must be followed when dealing with RNA probes. To fully use the large number of RNA FNAs available for bioanalysis and biomedicine, it is important ...
Bakchoul Tamam - - 2013
Protamine, routinely used post-cardiac surgery to reverse the anticoagulant effects of heparin, is known to be immunogenic. Observing patients with an otherwise unexplained rapid decrease in platelet count directly after protamine administration, we determined the incidence and clinical relevance of protamine-reactive antibodies in cardiac-surgery patients. In vitro these antibodies activated ...
Kozlowski Odile - - 2013
In patients with severe traumatic brain injury (TBI), a growth hormone deficiency (GHD) is frequent and may contribute to the cognitive sequelae and reduction in quality of life (QoL). Recent studies have suggested that GH replacement therapy (GHRT) can improve processing speed and memory. The aim of the study was ...
Butalia S - - 2013
AIM: To identify the clinical and socio-demographic factors associated with hospitalization for diabetic ketoacidosis in adults with Type 1 diabetes. METHODS: We combined clinical and administrative health data from a large urban diabetes clinic to perform a data linkage study. We identified adults (aged ≥ 18 years old) with Type 1 diabetes and linked ...
Zhang Weili - - 2013
ABSTRACT Background-Inter-individual differences in biological ageing could affect susceptibility to stroke. To date, the relationship between stroke and telomere shortening remain inconclusive; and sparse data is available to hemorrhagic stroke. Methods and Results- A Chinese case-control study was conducted, comprising 1756 cases (767 atherothrombosis, 494 lacunar infarction, and 486 hemorrhagic ...
Trujols Joan - - 2013
Background In the past two decades, there has been a growing interest in the development of a more patient-centred approach to assessing treatment outcomes. This interest has resulted in the increasing use of patient-reported outcome measures (PROMs) in both clinical trials and usual clinical practice. Aims To briefly discuss the ...
Klepper Kjetil - - 2013
ABSTRACT: BACKGROUND: Traditional methods for computational motif discovery often suffer from poor performance. In particular, methods that search for sequence matches to known binding motifs tend to predict many non-functional binding sites because they fail to take into consideration the biological state of the cell. In recent years, genome-wide studies ...
Yildiz Mustafa Zahıd - - 2013
The goal of this study was to investigate the relationship between the psychophysical vibrotactile thresholds of the Pacinian (P) channel and the mechanical properties of the skin at the fingertip. Seven healthy adult subjects (age: 23-30) participated in the study. The mechanical stimuli were 250-Hz sinusoidal bursts and applied with ...
Brooks Samantha K - - 2013
Background: The Practitioner Health Programme (PHP) was developed to provide expert assessment and support to practitioners (doctors and dentists) with mental and physical health problems affecting their ability to work. Aims: This paper examines the treatment outcomes of the practitioner-patients utilising PHP. Method: We assessed outcomes on consecutive patients using ...
Joesch Maximilian - - 2013
In the fly Drosophila melanogaster, photoreceptor input to motion vision is split into two parallel pathways as represented by first-order interneurons L1 and L2 (Rister et al., 2007; Joesch et al., 2010). However, how these pathways are functionally specialized remains controversial. One study (Eichner et al., 2011) proposed that the ...
Masi Laura - - 2013
OBJECTIVES: Kawasaki disease (KD) is an acute self-limited panvasculitis, primarily affecting young children, with an outstanding risk of cardiovascular complications. Fibroblast Growth Factor-23 (FGF23) is the latest member of the FGF family, acting on phosphate metabolism, which has been shown to display a potential role in the vascular remodelling. The ...
Scharman Elizabeth J - - 2013
OBJECTIVE:To conduct a systematic literature review to evaluate evidence-based recommendations for the prevention of rhabdomyolysis-associated acute renal failure (ARF).DATA SOURCES:PubMed (1966-December 2012), International Pharmaceutical Abstracts, Science Citation Index, and Cochrane databases (1970-December 2012) were searched. There were no language restrictions.STUDY SELECTION AND DATA EXTRACTION:Studies selected dealt with treatment of rhabdomyolysis ...
Liu Chih-Yi - - 2013
Focused ion beam lithography and a two-step anodization have been combined to fabricate a vertical fan-out platform containing an array of unique probes. Each probe comprises three anodic alumina nanochannels with a fan-out arrangement. The lithography is used to pattern an aluminum sheet with a custom-designed array of triangular 'cells' ...
Pratt Susan E - - 2013
PURPOSE: The oral prodrug of gemcitabine LY2334737 is cleaved systemically to gemcitabine; the mechanism responsible for hydrolysis is unknown. LY2334737 cytotoxicity was tested in the NCI-60 panel; mining of microarray expression data identified carboxylesterase (CES) as a top hydrolase candidate. Studies examined whether CES is responsible for hydrolysis and whether ...
Zhao Yongbiao - - 2013
In this paper, highly efficient and simple monochrome blue, green, orange and red organic light emitting diodes (OLEDs) based on ultrathin non-doped emissive layers (EMLs) have been reported. The ultrathin non-doped EML was constructed by introducing a 0.1 nm thin layer of pure phosphorescent dyes between hole transporting layer and ...
Antiel Ryan M - - 2013
OBJECTIVE To measure the implications of the new Accreditation Council for Graduate Medical Education duty hour regulations for education, well-being, and burnout. DESIGN Longitudinal study. SETTING Eleven university-based general surgery residency programs from July 2011 to May 2012. PARTICIPANTS Two hundred thirteen surgical interns. MAIN OUTCOME MEASURES Perceptions of the ...
Mikosch Jochen - - 2013
The highly exoergic nucleophilic substitution reaction F- + CH3 I shows strikingly different reaction dynamics than substitution reactions of larger halogen anions. Over a wide range of collision energies, a large fraction of indirect scattering via a long-lived hydrogen-bonded complex is found both in crossed-beam imaging experiments and in direct ...
Bhosale Sagar S - - 2013
Abstract Valsartan (VLT) is a highly selective and orally active antihypertensive drug. However, its oral administration is associated with drawbacks like low bioavailability. The objective of this study was to design and develop a transdermal delivery system for VLT using ethosomal carriers to investigate their enhanced transdermal delivery potential. VLT ...
Liu Yu-Lun - - 2013
In this study, we find that the optical anisotropy of graphene films could be used as an alternative quality factor for the rapid characterization of large-area graphene films prepared through chemical vapor deposition. We develop an angle-variable spectroscopic method to rapidly determine the optical anisotropy of graphene films. Unlike approaches ...
Chichester Jessica A - - 2013
The potential use of Bacillus anthracis as a bioterrorism weapon threatens the security of populations globally, requiring the immediate availability of safe, efficient and easily delivered anthrax vaccine for mass vaccination. Extensive research efforts have been directed toward the development of recombinant subunit vaccines based on protective antigen (PA), the ...
Serghei Anatoli - - 2013
Polymer systems having one, two or three dimensions on the nanometer length-scale can exhibit physical properties different from the bulk. The degree of disorder characteristic for large amounts of matter is strongly reduced and changes in symmetry are imposed by means of geometrical confinement. This could be used to induce ...
Rocchetti Laura - - 2013
Life cycle assessment (LCA) was applied to hydrometallurgical treatments carried out using a new portable prototype plant for the recovery of valuable metals from waste electrical and electronic equipment (WEEE). The plant was fed with the WEEE residues from physical processes for the recycling of fluorescent lamps, cathode ray tubes ...
Passera Katia - - 2013
ABSTRACT: BACKGROUND: Radiofrequency ablation (RFA) is one of the most promising non-surgical treatments for hepatic tumors. The assessment of the therapeutic efficacy of RFA is usually obtained by visual comparison of pre- and post-treatment CT images, but no numerical quantification is performed. METHODS: In this work, a novel method aiming ...
Kawaguchi Syota - - 2013
Luteinizing hormone (LH) is known as a key regulator of corpus luteum (CL) function, but the luteoprotective mechanisms of LH in the maintenance of bovine CL function are not well understood. The current study investigated if LH increases cell viability and induces cortisol conversion, and if the luteoprotective action of ...
Ritz Thomas - - 2013
ObjectiveAnxiety and panic are associated with the experience of a range of bodily symptoms, in particular unpleasant breathing sensations (dyspnea). Respiratory theories of panic disorder have focused on disturbances in blood gas regulation, but respiratory muscle tension as a source of dyspnea has not been considered. We therefore examined the ...
Volberg Vitaly - - 2013
What is already known about this subject Mexican-American children are at particularly high risk of obesity. Features of the perinatal environment, including maternal nutrition, anthropometry, glucose tolerance and growth rate during infancy are implicated in programming of obesity in the offspring. What this study adds Greater rate of weight or ...
Nielsen Hans Jørgen - - 2013
Abstract Objective. Results from monitoring studies using biomarkers in blood samples aiming at early detection of recurrent colorectal cancer (CRC) are presently evaluated. However, some serological biomarker levels are influenced by the surgical trauma, which may complicate translation of the levels in relation to recurrence. The primary purpose of the ...
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