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Novoyatleva Tatyana T Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, - - 2013
Pulmonary arterial hypertension (PAH) is a fatal disease for which no cure is yet available. The leading cause of death in PAH is right ventricular (RV) failure. Previously, the TNF receptor superfamily member fibroblast growth factor-inducible molecule 14 (Fn14) has been associated with different fibrotic diseases. However, so far there ...
Steele Christopher J - - 2013
Training during a sensitive period in development may have greater effects on brain structure and behavior than training later in life. Musicians are an excellent model for investigating sensitive periods because training starts early and can be quantified. Previous studies suggested that early training might be related to greater amounts ...
Pranzatelli Michael R - - 2013
ABSTRACT: BACKGROUND: B-cell dysregulation has been implicated but not fully characterized in pediatric opsoclonus-myoclonus syndrome (OMS), a neuroblastoma-associated neuroinflammatory disorder. OBJECTIVE: To assess the role of B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL), two critical B cell-modulating cytokines, as potential biomarkers of disease activity and treatment biomarkers in ...
Andrésdóttir G - - 2013
AIMS: Hydrogen sulphide levels are reduced in many disease states, including diabetes and end-stage renal disease. We aimed to determine whether urinary sulphate excretion, as a proxy for hydrogen sulphide, was associated with progression of diabetic nephropathy. METHODS: We conducted a post-hoc study of a prospective, randomized, controlled trial on ...
Chen Junying - - 2013
Redox-inactive metal ions play pivotal roles in regulating reactivities of high-valent metal-oxo species in a variety of enzymatic and chemical reactions. A mononuclear nonheme manganese(IV)-oxo complex bearing a pentadentate N5 ligand has been synthesized and used in the synthesis of a Mn(IV)-oxo complex binding scandium ions. The Mn(IV)-oxo complexes are ...
Caman Ozge Karadag - - 2013
INTRODUCTION: Hospitality sector employees constitute one of the key groups with respect to their secondhand tobacco smoke exposure at work. This study aimed to detect urinary cotinine and breath carbon monoxide (CO) levels among bar and restaurant employees in Ankara, as well as the employees' opinions on the new antitobacco ...
Gibson Roger C - - 2013
This study explored how locus of control (LOC), depression and quality of life (QOL) interplay in patients with sickle cell disease. One hundred and forty-three sickle cell clinic patients with consecutive clinic consultations completed the Multidimensional Health Locus of Control and Short Factor 36 (SF-36) scales as well as the ...
Adler N - - 2013
According to European legislation, an Environmental Risk Assessment (ERA) of veterinary medicinal products (VMPs) for dung fauna is required in the authorization process if the substance acts as a parasiticide for the treatment of pasture animals. In the past, however, the demonstration of the environmental safety of those VMPs for ...
Luciano Alberto Maria - - 2013
Oocytes isolated from cows of reproductive age with reduced antral follicle counts (AFC) have a diminished capacity of embryonic development, which may be related to alterations in the mechanism that directs the proper segregation of chromosomes. Since we demonstrated that progesterone receptor membrane component 1 (PGRMC1) is involved in chromosome ...
Gao Zhiqiang - - 2013
A simple and ultrasensitive label-free microRNA (miRNA) biosensor, based on hybridized miRNA-templated deposition of an insulating polymer film and electrochemical impedance spectroscopic detection, is described in this report. The biosensor is made of a monolayer of charge-neutral morpholino capture probes on an indium tin oxide (ITO)-coated glass slide. Upon hybridization, ...
Agarwal Garima - - 2013
ObjectiveTo evaluate optical rhinometry (ORM) using nasal provocation testing (NPT) as an objective tool to diagnose fungal allergic rhinitis (AR).Study DesignProspective.SettingTertiary academic center.MethodsWe prospectively enrolled healthy controls (HCs) and subjects with a clinical history of AR and positive skin prick test to Alternaria or Aspergillus antigens. Baseline measurements with an ...
Hwang Jih-Shang - - 2013
Enhanced photoelectrochemical (PEC) performances of Ga(2)O(3) and GaN nanowires (NWs) grown in situ from GaN were demonstrated. The PEC conversion efficiencies of Ga(2)O(3) and GaN NWs have been shown to be 0.906% and 1.09% respectively, in contrast to their 0.581% GaN thin film counterpart under similar experimental conditions. A low ...
Bath Sarah C - - 2013
OBJECTIVE: Iodine deficiency has recently been found in UK young and pregnant women, which is of concern given the importance of adequate iodine intake in pregnancy for fetal brain development. The WHO recommends that iodine deficiency in a population should be corrected through salt iodisation but there is a lack ...
Zhang Hong - - 2013
Morphological stability of polymer films is critically important for their applications as functional materials. The deformation of polymer surface at nanoscale may be significantly influenced due to the geometrical confinement. Herein, we constructed a mechanically heterogeneous polymer surface by phase separation in a thin polymer film and investigated the deformation ...
Cheng Tan - - 2013
Previous reports indicate a potential role for calcitonin in the treatment of osteoarthritis (OA). To evaluate this potential therapeutic role, we investigated the effect of calcitonin pretreatment on the activation of mitogen-activated protein kinase (MAPK) signaling and the expression of MMP-13 in IL-1β-induced chondrocytes, and further assessed its protective effect ...
Yancy William S - - 2013
OBJECTIVE: To examine whether the recent increasing prevalence of obesity was accompanied by variations in energy and macronutrient intakes by weight status. DESIGN: Time series of cross-sectional surveys. SETTING: National Health and Nutrition Examination Surveys (NHANES) in the USA. SUBJECTS: Adult participants of NHANES I (1971-1974), II (1976-1980), III (1988-1994) ...
Mert Tufan - - 2013
Several studies have reported that pulsed magnetic fields (PMFs) can be a choice of therapy for diabetic peripheral neuropathy. However, the exact underlying mechanism of PMF is still not known. The purpose of this study was, therefore, to investigate the effects of clodronate encapsulated with liposome, a specific agent depleting ...
Lima-Silva A E - - 2013
We examined the pacing strategy and the magnitude of the end spurt during a 200-kJ cycling time trial performed 12-14 h after an exercise protocol designed to reduce muscle glycogen content. 9 physically-active men performed 5 familiarization sessions and 2 experimental 200-kJ time trials in either a control condition (CON) or ...
Pavone Piero - - 2013
ABSTRACT: Hemi-hydranencephaly is a very rare condition characterized by complete or almost nearcomplete unilateral absence of the cortical cortex, which is filled by a sac of cerebrospinal fluid. Prenatal vascular disruption with occlusion of the carotid artery territories ipsilateral to the damaged brain is the presumed pathogenesis. We have selected ...
Lv Y - - 2013
Atomic force microscopy imaging combined with selective chemical etching is employed to quantitatively investigate three-dimensional (3D) composition distributions of single GeSi quantum rings (QRs). In addition, the 3D quantitative composition distributions and the corresponding conductance distributions are simultaneously obtained on the same single GeSi QRs by conductive atomic force microscopy ...
Domínguez-Martín Alicia - - 2013
For a better understanding of the versatile behaviour of adenine as a ligand, a series of 10 ternary copper(ii) complexes with deaza-adenine ligands [7-azaindole (1,6,7-trideaza-adenine, H7azain), 4-azabenzimidazole (1,6-dideaza-adenine, H4abim), 5-azabenzimidazole (3,6-dideaza-adenine, H5abim), and 7-deaza-adenine (H7deaA)] have been synthesised and characterised by X-ray diffraction. Likewise, all the compounds studied have been ...
Kamio Noriaki - - 2013
Visceral adipose tissue-derived serine protease inhibitor (vaspin), an adipokine that was recently identified in a rat model of type 2 diabetes, has been suggested to have an insulin-sensitizing effect. In this study, we investigated whether vaspin inhibits receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis using two types of osteoclast ...
Hajdarevic Senada - - 2013
Early care seeking is important for prognosis of malignant melanoma. Coping styles in decision-making to seek care can relate to prognosis since avoidant strategies could delay care seeking. The aim of this study was to compare self-reported coping styles in decision-making between men and women diagnosed with malignant melanoma. We ...
Uddin Md Nasir - - 2013
Transverse relaxation (T(2) ) mapping has many applications, including imaging of iron accumulation in grey matter. Using the typical multiecho spin-echo sequence with long echo trains, stimulated echo compensation can enable T(2) fitting under conditions of variable radio frequency homogeneity arising from slice profile and in-plane radio frequency variation. Substantial ...
Guzel Savas - - 2013
Purpose. This study is designed to evaluate the interrelationships among adipokines-visfatin, leptin, and tumor necrosis factor-α (TNF-α)- and insulin resistance (IR) in overt (n = 40) and subclinic hypothyroid (n = 25) patients and compare our findings with sex and body mass index-matched healthy controls (n = 25). Methods. Serum ...
Cohen S R - - 2013
BACKGROUND: Previous studies have identified the role of family support in mitigating the stress of parents caring for a child with intellectual disability. Less is known about families whose members are willing but unable to support each other because of geographical, structural and economic barriers. Our study examined the contribution ...
Buck-Koehntop Bethany A - - 2013
DNA methylation is an epigenetic mark that is essential for the development of mammals; it is frequently altered in diseases ranging from cancer to psychiatric disorders. The presence of DNA methylation attracts specialized methyl-DNA binding factors that can then recruit chromatin modifiers. These methyl-CpG binding proteins (MBPs) have key biological ...
Corwin Michael T - - 2013
BackgroundThe pancreas is an increasingly recognized site of renal cell carcinoma metastases. It is important to determine the optimal MDCT protocol to best detect RCC metastases to the pancreas.PurposeTo compare the rate of detection of renal cell carcinoma metastases to the pancreas between arterial and portal venous phase MDCT.Material and ...
Bittencourt Maura Krähembühl Wanderley - - 2013
Abstract Purpose: To verify the safety and efficacy of botulinum toxin type A (BoNT/A) to promote protective ptosis in dogs. Methods: In this prospective interventional study, a total of 10 dogs underwent transcutaneous anterior chemodenervation of levator palpebral superioris with 15 U of BoNT/A. The systemic changes, ocular mobility, visual function, ...
Lee Young Chan - - 2013
ObjectiveTo compare the efficacy, relapse, and adverse effects between intralesional injection and mouth rinse of triamcinolone acetonide (TA) in patients with oral lichen planus (OLP).Study DesignA randomized controlled study.SettingCollege medical center.Subjects and MethodsForty consecutive patients, who had been diagnosed with OLP, were recruited. Participants were randomly divided into 2 groups ...
Pauwels Ine - - 2013
BACKGROUND: Recent studies suggest an association between rare variants in Mediterranean fever (MEFV), the gene underlying the auto-inflammatory disorder Familial Mediterranean Fever (FMF), the risk to develop multiple sclerosis (MS) and severity of MS. OBJECTIVE: The objective of this study is to investigate these findings in a Belgian MS population ...
Son Hyun-Soo - - 2013
Despite the antitumour effect of ursolic acid observed in several cancers, the underlying mechanism remains unclear. Thus, in the present study, the roles of AMP-activated protein kinase (AMPK) and glycogen synthase kinase 3 beta (GSK3β) were examined in ursolic acid induced apoptosis in HepG2 hepatocellular carcinoma cells. Ursolic acid significantly ...
Ian Ka Wa - - 2013
We report a new and simple low temperature soft reflow process using solvent vapour. The combination of this soft reflow and conventional i-line lithography enables low cost, highly efficient fabrication at the deep-submicron scale. Compared to the conventional thermal reflow process, the key benefits of the new soft reflow process ...
Yu Yejin - - 2013
Abstract 1. Organic anion transporting polypeptides (OATPs) are a family of transporter proteins that have been extensively recognized as key determinants of absorption, distribution, metabolism and excretion of various drugs. Human OATP1A2 has been demonstrated to transport wide spectrum of endogenous and exogenous compounds. Study on OATP1A2 orthologues of other ...
Zhang Yong-Wei - - 2013
We study the self-assembly of ordered nanostructures, i.e., nanorings (NRs), quantum dots (QDs), epitaxially grown on a polygonal cross-section nanowire (PCS-NW) using both theoretical and phase-field modeling. Our studies show that by increasing the PCS-NW size, transitions from ordered NRs, to ordered QDs on facets, and further to ordered QDs ...
Michaels Patrick J - - 2013
Background: For persons with mental illness, stigma diminishes employment and independent living opportunities as well as participation in psychiatric care. Public stigma interventions have sought to ameliorate these consequences. Aims: Evaluation of anti-stigma programs' impact is typically accomplished with self-report questionnaires. However, cultural mores encourage endorsement of answers that are ...
Goertz Christine M - - 2013
ABSTRACT: BACKGROUND: Low back pain is a prevalent and debilitating condition that affects the health and quality of life of older adults. Older people often consult primary care physicians about back pain, with many also receiving concurrent care from complementary and alternative medicine providers, most commonly doctors of chiropractic. However, ...
Voss Joachim G - - 2013
Purpose: Human immunodeficiency virus (HIV)-related fatigue (HRF) is multicausal and potentially related to mitochondrial dysfunction caused by antiretroviral therapy with nucleoside reverse transcriptase inhibitors (NRTIs). Methodology: The authors compared gene expression profiles of CD14+ cells of low versus high fatigued, NRTI-treated HIV patients to healthy controls (n = 5/group). The ...
Morandi Bill - - 2013
Make it simple! A convenient and general palladium-catalyzed oxidation of internal olefins to ketones is reported. The transformation occurs at room temperature and shows wide substrate scope. Applications to the oxidation of seed-oil derivatives and a bioactive natural product are described, as well as intriguing mechanistic features.
Behr J - - 2013
Idiopathic pulmonary fibrosis is a fatal lung disease with a variable and unpredictable natural history and limited treatment options. Since publication of the ATS-ERS statement on IPF in the year 2000 diagnostic standards have improved and a considerable number of randomized controlled treatment trials have been published necessitating a revision. ...
Fujiwara Yutaka - - 2013
We report the synthesis and photochemical and photophysical properties of double alkylene-strapped 9,10-diphenylanthracene derivatives 3a-c (a: C6 strap, b: C7 strap, c: C8 strap) in which the reactive central aromatic ring of the anthracene moiety is protected by the double alkylene straps. Thus, 3a-c were much more resistant to photochemical ...
Busemann A - - 2013
Background: Risk reducing measures like the surgical checklist have been proven to reduce effectively adverse events and improve patient safety and teamwork among surgical staff members. Nevertheless, many physicians still refuse to use even simple safety tools like the WHO checklist. A progress in patient safety can only be achieved ...
Atolagbe Peter O - - 2013
Ruthenium(II) dichloride complexes of two chiral tetradentate aminosulfoxide ligands, varying only in the N-N linker, were synthesized. With each ligand, two major isomers formed, and these were structurally assigned and characterized through a combination of NMR and UV-vis spectroscopies, X-ray crystallography, and density functional theory calculations. The cis-β geometric isomer ...
Dale Alexis - - 2013
Maintaining a constant representation of our heading as we move through the world requires the accurate estimate of spatial orientation. As one turns (or is turned) toward a new heading, signals from the semi-circular canals are relayed through the vestibular system to higher-order centers that encode head direction. To date, ...
Dalakouras Athanasios - - 2013
RNA-directed DNA methylation (RdDM) involves sequence-specific guiding of the de novo methylation machinery to complementary genomic DNA by RNA molecules. It is still elusive whether guide RNAs bind directly to DNA or to nascent transcripts produced from it. Even the nature of the guide RNAs is not elucidated. RNA interference ...
Alliegro Mary Anne - - 2013
The nucleolinus is a nuclear subcompartment long ago posited to play a role in cell division. In a recent study using surf clam oocytes, cytoplasmic foci containing a nucleolinar protein were shown to later recruit γ-tubulin, identifying them as centrosomal precursors. ( 1) We now demonstrate the presence of structural ...
Nuzhnyy D - - 2013
Composites of multiwalled carbon nanotubes with poly(ethylene terephthalate) (PET-MWCNT) with up to 3 vol% MWCNTs were prepared and characterized by broad-band AC conductivity and dielectric spectroscopy up to the infrared range using several techniques. A very low electrical percolation threshold of 0.07 vol% MWCNTs was revealed from the low-frequency conductivity plateau as ...
Zheng Jian - - 2013
Graft-versus-host disease (GVHD) is a lethal complication of allogeneic bone marrow transplantation (BMT). Immunosuppressive agents are currently used to control GVHD but may cause general immune suppression and limit the effectiveness of BMT. Adoptive transfer of regulatory T cells (T(regs)) can prevent GVHD in rodents, suggesting a therapeutic potential of ...
Dickens Chris - - 2013
ObjectiveDespite previous intervention trials, it is unclear which psychological treatments are most effective for people with coronary heart disease (CHD). We have conducted a systematic review with meta-regression to identify the characteristics of psychological interventions that improve depression and depressive symptoms among people with CHD.MethodsSearches of multiple electronic databases up ...
Gaynor Keith - - 2013
Background Self-referring is an important pathway to care that is being used increasingly by services, but little research has been conducted in this area. Aims To examine whether self-referrers would (i) be representative of the local community; (ii) be significantly psychologically distressed; (iii) be demographically similar to GP consulters and ...
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