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Naigles Letitia R LR Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA. - - 2013
In two experiments, typically developing (TD) children, high-functioning children with autism (HFA) and children with a history of autism who have achieved optimal outcomes (OOs), matched on age (M = 13 years) and nonverbal IQ, were asked to extend properties of categories to new items (categorical induction). All groups demonstrated ...
Froehlich Wendy W Child and Adolescent Psychiatry, Department of Psychiatry, School of Medicine, Stanford University, Stanford, CA 94305, USA. - - 2013
To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4-18, were included. 20 ...
Calsyn Donald A DA Alcohol and Drug Abuse Institute and the Department of Psychiatry and Behavioral Sciences, University of Washington, 1107 NE 45th St., Ste. 120, Seattle, WA 98105, USA. - - 2013
Heterosexual anal intercourse (HAI) is an understudied risk behavior among women and men in substance abuse treatment. Rates of HAI for women (n = 441) and men (n = 539) were identified for any, main and casual partners. More men (32.8 %) than women (27.1 %) reported engaging in HAI in the previous 90 days. These rates ...
Seelke Adele M H AM Center for Neuroscience, University of California, Davis, Davis, California 95618, - - 2013
Throughout development both the body and the brain change at remarkable rates. Specifically, the number of cells in the brain undergoes dramatic nonlinear changes, first exponentially increasing in cell number and then decreasing in cell number. Different cell types, such as neurons and glia, undergo these changes at different stages ...
Grau Lauretta E LE Yale University School of Public Health, New Haven, CT 06520-8034, USA. - - 2013
Cultural adaptation is an important step in the process of implementing health promotion interventions that, having been proven to be effective in one culture, are being applied in another. This study describes the results of a formative investigation to culturally adapt a STI/HIV risk reduction intervention for use in St. ...
Wong Koon-Pong KP Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. - - 2013
Accurate determination of the plasma input function (IF) is essential for absolute quantification of physiological parameters in positron emission tomography (PET). However, it requires an invasive and tedious procedure of arterial blood sampling that is challenging in mice because of the limited blood volume. In this study, a hybrid modeling ...
Suzuki Eiji E Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, - - 2013
Fli-1 belongs to the Ets transcription factor family and is expressed in haematopoietic cells, including most of the cells that are active in immunity. The mononuclear phagocytes, i.e. monocytes, macrophages and dendritic cells, originate in haematopoietic stem cells and play an important role in immunity. To assess the role of ...
Henning Justin R JR Department of Surgery, S. Arthur Localio Laboratory, New York University School of Medicine, New York, NY 10016, - - 2013
Nonalcoholic steatohepatitis (NASH) is the most common etiology of chronic liver dysfunction in the United States and can progress to cirrhosis and liver failure. Inflammatory insult resulting from fatty infiltration of the liver is central to disease pathogenesis. Dendritic cells (DCs) are antigen-presenting cells with an emerging role in hepatic ...
Schwartz Ann V AV University of California San Francisco, San Francisco, CA, USA. - - 2013
In rodent models, undercarboxylated osteocalcin (ucOC) acts as a hormone that promotes insulin sensitivity and secretion. If ucOC plays a similar role in humans, then antiresorptive therapies, which reduce ucOC levels, may increase the risk of insulin resistance and diabetes. We tested whether antiresorptive therapies result in higher fasting glucose, ...
Niger Corinne C Department of Orthopaedics, University of Maryland, School of Medicine, Baltimore, MD, - - 2013
Connexin43 (Cx43) plays a critical role in osteoblast function and bone mass accrual, yet the identity of the second messengers communicated by Cx43 gap junctions, the targets of these second messengers and how they regulate osteoblast function remain largely unknown. We have shown that alterations of Cx43 expression in osteoblasts ...
Reid Allecia E AE Center for Interdisciplinary Research on AIDS, Yale University, 135 College Street, New Haven, CT 06510, USA. - - 2013
Few studies have examined whether and how receiving an sexually transmitted disease (STD) diagnosis while in a romantic relationship relates to condom use and psychosocial sexual outcomes. Using dyadic data, we examined associations of a personal or a partner's STD diagnosis during a relationship with condom use, monogamy intentions, condom ...
Saki Forough F Department of Pediatric Endocrinology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, - - 2013
Juvenile Paget's disease (JPD) is a rare heritable osteopathy characterized biochemically by markedly increased serum alkaline phosphatase (ALP) activity emanating from generalized acceleration of skeletal turnover. Affected infants and children typically suffer bone pain and fractures and deformities, become deaf, and have macrocranium. Some who survive to young adult life ...
Chen Ying Y Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, - - 2013
Endochondral bone formation is a multistep process during which a cartilage primordium is replaced by mineralized bone. Several genes involved in cartilage and bone development have been identified as target genes for the Snail family of zinc finger transcriptional repressors, and a gain-of-function study has demonstrated that upregulation of Snai1 ...
González Pau P Molecular Neurology Laboratory, Hospital Nacional de Paraplejicos-HNP, Toledo, - - 2013
Wnt proteins play a critical role in central nervous system development and have been implicated in several neuropathologies, including spinal cord injury (SCI). Ryk, an unconventional Wnt receptor, regulates axonal regeneration after SCI, although its expression pattern in this neuropathology remains unclear. Therefore, we sought to define the spatiotemporal and ...
Flynn Jamie R JR School of Biomedical Sciences and Pharmacy, University of Newcastle, New South Wales, - - 2013
Following spinal cord injury (SCI), anatomical changes such as axonal sprouting occur within weeks in the vicinity of the injury. Exercise training enhances axon sprouting; however, the exact mechanisms that mediate exercised-induced plasticity are unknown. We studied the effects of exercise training after SCI on the intrinsic and synaptic properties ...
Kamiyama Toshiya T Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. - - 2013
The altered N-glycosylation of glycoproteins has been suggested to play an important role in the behavior of malignant cells. Using glycomics technology, we attempted to determine the specific and detailed N-glycan profile for hepatocellular carcinoma (HCC) and investigate the prognostic capabilities. From 1999 to 2011, 369 patients underwent primary curative ...
Yu Ming-Lung ML Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital and Kaohsiung Medical University College of Medicine, Kaohsiung, - - 2013
Patients dually infected with hepatitis C virus (HCV)/hepatitis B virus (HBV) have a higher risk of developing advanced liver disease or hepatocellular carcinoma compared with monoinfected patients. Yet, there is a similar rate of sustained virologic response (SVR) after peginterferon alfa-2a and ribavirin combination therapy in these patients compared with ...
Colaianna Marilena M Department of Clinical and Experimental Medicine, University of Foggia, Foggia, - - 2013
Psychosocial stress alters the hypothalamic-pituitary-adrenal axis (HPA-axis). Increasing evidence shows a link between these alterations and oxidant elevation. Oxidative stress is implicated in the stress response and in the pathogenesis of neurologic and psychiatric diseases. NADPH oxidases (NOXs) are a major source of reactive oxygen species (ROS) in the central ...
Desgrippes Romain R CHU Rennes, Service des maladies du foie, Rennes, - - 2013
An excess of visceral adipose tissue could be involved as a modulator of the penetrance of HFE hemochromatosis since fat mass is associated with overexpression of hepcidin and low transferrin saturation was found to be associated with being overweight in women. This study was aimed at assessing the relationship between ...
Satoskar Anjali A - - 2013
In children and adults, Henoch-Schönlein purpura (HSP) has a characteristic clinical presentation that includes a purpuric lower extremity skin rash, IgA-dominant glomerulonephritis, and abdominal and joint pain. A similar clinical presentation can be seen in adults who have a systemic infection with methicillin-resistant Staphylococcus aureus. It is critically important to ...
Bayart Emilie - - 2013
The unlimited proliferation capacity of embryonic stem cells (ESCs) combined with their pluripotent differentiation potential in various lineages raised great interest in both the scientific community and the public at large with hope for future prospects of regenerative medicine. However, since ESCs are derived from human embryos, their use is ...
Cramer Alona O AO Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neuroscience, NIHR Biomedical Research Centre, University of Oxford, Oxford OX3 9DU, - - 2013
Induced pluripotent stem cells (iPSc) are a scientific and medical frontier. Application of reprogrammed somatic cells for clinical trials is in its dawn period; advances in research with animal and human iPSc are paving the way for retinal therapies with the ongoing development of safe animal cell transplantation studies and ...
Fischer Beat B - - 2013
In photosynthetic organisms, excited chlorophylls (Chl) can stimulate the formation of singlet oxygen ((1)O(2)), a highly toxic molecule that acts in addition to its damaging nature as an important signaling molecule. Thus, due to this dual role of (1)O(2), its production and detoxification have to be strictly controlled. Regulation of ...
Anke Audny A Department of Physical Medicine and Rehabilitation, University Hospital of Northern Norway and University of Tromsø, Tromsø, Norway. - - 2013
To investigate levels of life satisfaction in subjects with long-term musculoskeletal pain in relation to pain characteristics and coping. Cross-sectional study. A total of 232 (42%) respondents answered self--report questionnaires regarding life satisfaction, self-efficacy, sense of coherence, pain distribution and pain intensity at rest and during activity. Levels of life ...
Berkes Marschall B - - 2013
The treatment of proximal humerus fractures continues to evolve. While the many of these injuries can be managed nonoperatively, a certain percentage require operative treatment. Open reduction internal fixation can offer excellent outcomes when performed in the appropriate patient and utilizing proper techniques. This article reviews the most up-to-date literature ...
Navaneethan Sankar D - - 2013
Electronic health records (EHRs) were first developed in the 1960s as clinical information systems for document storage and retrieval. Adoption of EHRs has increased in the developed world and is increasing in developing countries. Studies have shown that quality of patient care is improved among health centers with EHRs. In ...
Turner Linda - - 2013
This study evaluated whether electrodermal resistance at acupuncture points (AP) systematically varies as a function of pain. The study was conceived as a proof-of-principle study in support of research on acupuncture and other complementary medicine approaches. Specifically, this study investigates whether or not electrodermal activity systematically differentiates arthritis patients with ...
Donohoe G G Neuropsychiatric Genetics Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, St. James Hospital, Dublin, Ireland. - - 2013
The single-nucleotide polymorphism (SNP) rs10503253, located within the CUB and Sushi multiple domains-1 (CSMD1) gene on 8p23.2, was recently identified as genome-wide significant for schizophrenia (SZ), but is of unknown function. We investigated the neurocognitive effects of this CSMD1 variant in vivo in patients and healthy participants using behavioral and ...
Clarke J M JM Duke Cancer Institute and the Duke Prostate Center, Department of Medicine, Division of Medical Oncology, Duke University Medical Center, DUMCBox 102002, Durham, NC 27710, - - 2013
In recent years, great success has been achieved on many fronts in the treatment of men with metastatic castration-resistant prostate cancer (CRPC), including novel chemotherapeutics, immunotherapies, bone microenvironment-targeted agents, and hormonal therapies. Numerous agents are currently in early-phase clinical trial development for the treatment of advanced prostate cancer. These novel ...
Montague Enid E Division of General Internal Medicine and Geriatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. - - 2013
The aim of this study was to understand technology and system characteristics that contribute to nurses' ratings of trust in a smart intravenous pump. Nurses' trust in new technologies can influence how technologies are used. Trust in technology is defined as a person's belief that a technology will not fail ...
Tan Wei - - 2013
The BCL2 gene encodes an integral outer mitochondrial membrane protein (25 kDa) which regulates the apoptotic death of cells. There is a 25-nucleotide G-rich sequence in the 5'-untranslated region (5'-UTR) of the BCL2 mRNA, which can adopt a G-quadruplex structure. Small molecules which could tightly bind to this structure have a ...
Markey Oonagh - - 2013
An altered gastric emptying (GE) rate has been implicated in the aetiology of obesity. The (13) C-octanoic acid breath test (OBT) is frequently used to measure GE, and the cumulative percentage of (13) C recovered (cPDR) is a common outcome measure. However, true cPDR in breath is dependent on accurate ...
Buckley Michael - - 2013
The 19th century excavation of an exceptionally well-preserved Early Bronze Age high status log-coffin burial from northern England, dated to 2200-2020 BC, yielded a 'food residue' collected from the inside of an accompanying bark vessel. This residue contained fibrous stitching that was used to hold the bark walls of the ...
Kim Jin Young - - 2013
Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family which has been shown to play a role in inflammation and in the regulation of angiogenesis. In general, chemokines are susceptible to proteolytic cleavage in amino and carboxy terminal regions, which usually results in dramatic changes ...
Thevis Mario - - 2013
Clenbuterol (4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol) is approved for human and veterinary use primarily for the treatment of pulmonary afflictions. Despite the authorized administration in cases of medical indications, the misuse of clenbuterol in animal husbandry as well as elite and amateur sport has frequently been reported, arguably due to growth-promoting properties. Due ...
Roeser Julien - - 2013
Cleavage of peptide bonds C-terminal to tyrosine and tryptophan after electrochemical oxidation may become a complementary approach to chemical and enzymatic cleavage. A chemical labeling approach specifically targeting reactive cleavage products is presented here and constitutes a promising first step towards the development of a new proteomics workflow. Hexylamine was ...
Zhu Lin - - 2013
Bromadiolone and brodifacoum, two common anticoagulant rodenticides, are involved in the majority of anticoagulant rodenticide poisoning cases in humans in China. Hair analysis can provide long-term information on drug exposure. A method using liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) was developed and validated for the measurement of bromadiolone ...
Tóth Katalin - - 2013
The aflatoxin mycotoxins are particularly hazardous to health when present in food. Therefore, from an analytical point of view, knowledge of their mass spectrometric properties is essential. The aim of the present study was to describe the collision-induced dissociation behavior of the four most common aflatoxins: B1, B2, G1 and ...
De Franco E E Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, - - 2013
Recessive PDX1 (IPF1) mutations are a rare cause of pancreatic agenesis, with three cases reported worldwide. A recent report described two cousins with a homozygous hypomorphic PDX1 mutation causing permanent neonatal diabetes with subclinical exocrine insufficiency. The aim of our study was to investigate the possibility of hypomorphic PDX1 mutations ...
Moya Monica L ML Department of Biomedical Engineering, University of California, Irvine, California, - - 2013
Replicating in vitro the complex in vivo tissue microenvironment has the potential to transform our approach to medicine and also our understanding of biology. In order to accurately model the 3D arrangement and interaction of cells and extracellular matrix, new microphysiological systems must include a vascular supply. The vasculature not ...
Wang Xi-Sen XS Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, - - 2013
A highly porous porphyrin-based organic polymer, PCPF-1, was constructed via homo-coupling reaction of the custom-designed porphyrin ligand, 5,10,15,20-tetrakis(4-bromophenyl)porphyrin. PCPF-1 possesses a large BET surface area of over 1300 m(2) g(-1) (Langmuir surface area of over 2400 m(2) g(-1)) and exhibits strong hydrophobicity with a water contact angle of 135°, and ...
Yamada Shinya S 1 Department of Cardiology and Hematology, Fukushima Medical University , Fukushima, Japan - - 2013
Senescence marker protein-30 (SMP30) decreases with aging, and SMP30 knockout (KO) mice show a short life with increased oxidant stress. We assessed the effect of oxidant stress with SMP30 deficiency in coronary artery spasm and clarify its underlying mechanisms. We measured vascular responses to acetylcholine (ACh) and sodium nitroprusside (SNP) ...
Zhang Qingzhi - - 2013
This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).
Kulminski Alexander M AM Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708, USA. - - 2013
The inherent complexity of aging-related traits can temper progress in unraveling the genetic origins of healthspan. We focus on two generations in the Framingham Heart Study, the original (FHS) and offspring (FHSO) cohorts, to determine whether aging-related processes in changing environments can substantially impact the role of lipid-related genes discovered ...
Gregory Christopher D CD MRC Centre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, Edinburgh, United Kingdom. - - 2013
It is well known that an important property of apoptosis is the prevention of cancer. However, it is becoming increasingly clear that apoptotic cells have the capacity to activate reparative and regenerative responses, which have the potential to make significant impact on pathological processes underlying autoimmune disease and cancer. Those ...
Chang Jinsam J Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, College of Veterinary Medicine Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, - - 2013
Arginase I (Arg1), an enzyme expressed by many cell types including myeloid cells, can regulate immune responses. Expression of Arg1 in myeloid cells is regulated by a number of cytokines and tissue factors that influence cell development and activation. Retinoic acid, produced from vitamin A, regulates the homing and differentiation ...
Duong Anthony D AD William G. Lowrie Department of Chemical and Biomolecular Engineering, College of Arts and Sciences, The Ohio State University , Columbus, Ohio 43210, - - 2013
Leishmaniasis is a disease caused by the intracellular protozoan, Leishmania. A current treatment for cutaneous leishmaniasis involves the delivery of imidazoquinolines via a topical cream. However, there are no parenteral formulations of imidazoquinolines for the most deadly version of the disease, visceral leishmaniasis. This work investigates the use of electrospray ...
Dawson D V DV Dows Institute for Dental Research, University of Iowa, N450 DSB, Iowa City, Iowa 52242, - - 2013
As one moves from the skin across the vermilion region of the lip and into the oral cavity, the oral mucosa is encountered. The oral mucosa consists of connective tissue known as the lamina propria covered by a stratified squamous epithelium. In the regions of the hard palate and gingiva, ...
Rizzoli R R Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland. - - 2013
Vitamin D insufficiency has deleterious consequences on health outcomes. In elderly or postmenopausal women, it may exacerbate osteoporosis. There is currently no clear consensus on definitions of vitamin D insufficiency or minimal targets for vitamin D concentrations and proposed targets vary with the population. In view of the potential confusion ...
Frank Aaron T AT Department of Chemistry, University of California Irvine 1102 Natural Sciences 2, Irvine, California 92697, - - 2013
The development of methods for predicting NMR chemical shifts with high accuracy and speed is increasingly allowing use of these abundant, readily accessible measurements in determining the structure and dynamics of proteins. For nucleic acids, however, despite the availability of semiempirical methods for predicting (1)H chemical shifts, their use in ...
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