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Cooky Cheryl - - 2013
On August 19, 2009, Caster Semenya, South African track star, won a gold medal in the women's 800-meter event. According to media reports, on the same day, the International Association of Athletics Federations (IAAF) ordered Semenya to undergo gender verification testing. This article critically assesses the main concepts and claims ...
Harris R Alan RA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, - - 2013
Metastable epialleles (MEs) are mammalian genomic loci where epigenetic patterning occurs before gastrulation in a stochastic fashion leading to systematic interindividual variation within one species. Importantly, periconceptual nutritional influences may modulate the establishment of epigenetic changes, such as DNA methylation at MEs. Based on these characteristics, we exploited Infinium HumanMethylation450 ...
Gagnon Kevin J - - 2013
The structural change and resilience of a single crystal of a metal-organic framework (MOF), Zn(HO3PC4H8PO3H) •2H2O (ZAG-4), was investigated under high pressures (0 - 9.9 GPa) using in situ single crystal X-ray diffraction. Although the unit cell volume decreases over 27%, the quality of the single crystal is retained and ...
Chisada Shin-Ichi - - 2013
Vibrios, distributed in marine and brackish environments, can cause vibriosis in fish and shellfish under appropriate conditions. Previously, we clarified by thin-layer chromatography (TLC) overlay assay that (35) S-labeled Vibrio trachuri adhered to GM4 isolated from red sea bream intestine (Chisada et al. Biochem. Biophys. Res. Commun. 333, 367-373, 2005). ...
Vert-pre Katyana A - - 2013
Fish stocks fluctuate both in abundance and productivity (net population increase), and there are many examples demonstrating that productivity increased or decreased due to changes in abundance caused by fishing and, alternatively, where productivity shifted between low and high regimes, entirely unrelated to abundance. Although shifts in productivity regimes have ...
Thai Julie N JN Division of Geriatrics, Department of Medicine, University of California at San Francisco, San Francisco, California 94121, - - 2013
To explore clinician choice of whether to discuss prognosis with their frail older patients. Qualitative interview study. Primary care clinicians were recruited from nursing homes, community-based clinics, and academic medical centers. Three geriatric nurse practitioners, nine geriatricians, five general internists, and three family medicine physicians with a mean age of ...
Han Na-Young - - 2013
OBJECTIVE: Inflammatory bowel disease (IBD) is a disease showing relapsing and remitting inflammatory courses of the colon and small intestine, mostly Crohn's disease (CD) and ulcerative colitis (UC). Biomarkers discriminating UC and CD, especially in cases with indeterminate type, and reflecting disease activities are still lacking, but advanced technology of ...
Fotopoulou C C Department of Gynecology, Charité University Medical Center Berlin, 13353 Berlin, Germany. - - 2013
To evaluate surgical outcome and survival benefit after quaternary cytoreduction (QC) in epithelial ovarian cancer (EOC) relapse. We systematically evaluated all consecutive patients undergoing QC in our institution over a 12-year period (October 2000-January 2012). All relevant surgical and clinical outcome parameters were systematically assessed. Forty-nine EOC patients (median age: ...
Wu Y P - - 2013
AIMS: In young people with Type 1 diabetes, depressive symptoms and shared responsibility for management of diabetes impact upon diabetes management and control. However, the simultaneous effects of both depressive symptoms and parental involvement on diabetes self-care and glycaemic control have not been examined. Thus, the aim of the current study ...
Dikic Nenad - - 2013
Recent positive doping cases and a series of mistakes of medical doctors of the International Federation of Basketball have reopened the debate about the role of medical doctor in elite sport. This study shows that some sports physicians involved in recent positive doping cases are insufficiently aware of the nuances ...
Winther Åsa M E ÅM Department of Neuroscience, DBRM, Karolinska Institutet, von Eulers väg 3, 171 77 Stockholm, - - 2013
Dynamin-associated protein 160 kDa (Dap160)/intersectin interacts with several synaptic proteins and affects endocytosis and synapse development. The functional role of the different protein interaction domains is not well understood. Here we show that Drosophila Dap160 lacking the dynamin-binding SH3 domains does not affect the development of the neuromuscular junction but ...
Thamotharan Shanthie S Department of Pediatrics, Division of Neonatology and Developmental Biology, Neonatal Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, - - 2013
We have shown in vitro a hypoxia-induced time-dependent increase in facilitative glucose transporter isoform 3 (GLUT3) expression in N2A murine neuroblasts. This increase in GLUT3 expression is partially reliant on a transcriptional increase noted in actinomycin D and cycloheximide pretreatment experiments. Transient transfection assays in N2A neuroblasts using murine glut3-luciferase ...
Meschia James F - - 2013
The field of stroke genetics continues to make substantive advances. Large-scale partnerships have led to meta-analyses in ischemic and hemorrhagic stroke, which are yielding reproducible genetic risk factors. Most ischemic stroke risk factors seem to be specific to type, for example, large-vessel stroke. Progress is being made in understanding the ...
López De Padilla Consuelo M CM Division of Rheumatology, Mayo Clinic, Rochester, Minnesota 55905, - - 2013
To investigate B cell survival cytokine messenger RNA (mRNA) levels as biomarkers of idiopathic inflammatory myopathies (IIM). We measured and compared mRNA levels of B cell survival cytokines by quantitative real-time polymerase chain reaction in 98 patients with IIM, 38 patients with systemic lupus erythematosus, and 21 healthy controls. The ...
Xu Xiao-Bo - - 2013
A Ni(0)-catalyzed intermolecular cross-coupling of various functionalized thiols and aryl iodides has been developed and successfully extended to less explored intramolecular versions, where thioacetates could also be utilized as the strategic surrogate. Air-stable precatalysts, very mild conditions, and an easy protocol allow rapid access to medicinally useful aryl thioethers, as ...
Yadegarfar G G Department of Primary Care and Public Health, Imperial College London, London, - - 2013
Quality of life is an important end point in clinical trials, yet there are few quality of life questionnaires for neuroendocrine tumours. This international multicentre validation study assesses the QLQ-GINET21 Quality of Life Questionnaire in 253 patients with gastrointestinal neuroendocrine tumours. All patients were requested to complete two quality of ...
Nieuwenhuijsen Mark J - - 2013
ABSTRACT: BACKGROUND: Various epidemiological studies have suggested associations between environmental exposures and pregnancy outcomes. Some studies have tempted to combine information from various epidemiological studies using meta-analysis. We aimed to describe the methodologies used in these recent meta-analyses of environmental exposures and pregnancy outcomes. Furthermore, we aimed to report their ...
Góra Robert W - - 2013
The origins of stabilization in the short strong hydrogen bonds commonly referred to as "resonance-assisted" (RAHB) have been revisited using the modern valence-bond theory, the hybrid variational-perturbational interaction energy decomposition scheme and atoms in molecules (AIM) analysis. Dimers of carboxylic acids and amides have been chosen as the model structures ...
Görgün Güllü Topal GT Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. - - 2013
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell population with the ability to suppress immune responses. MDSCs have been characterized in infections, inflammatory diseases, and solid tumors; however, their presence and role in the tumor-promoting, immune-suppressive microenvironment in hematologic malignancies remains unclear. We assessed the presence, frequency, and ...
Chen Mingqing - - 2013
To present a new method of estimating 3D positions of the ipsi-lateral hemi-diaphragm apex (IHDA) from 2D projection images of mega-voltage cone beam CT (MVCBCT). The detection framework reconstructs a 3D volume from all the 2D projection images. An initial estimated 3D IHDA position is determined in this volume based ...
Haferkamp Sebastian - - 2013
A large proportion of human melanomas harbor a mutation leading to permanent activation of the serine/threonine kinase BRAF, and as a consequence, they have developed dependence on BRAF/MAPK signaling. Accordingly, BRAF inhibitors such as Vemurafenib show a good anti-tumorigenic effect on metastases with the BRAF(V600E) mutation. Although an initial period ...
Radomska Katarzyna J - - 2013
Linkage, association and expression studies previously pointed to the human QKI, KH domain containing, RNA-binding (QKI) as a candidate gene for schizophrenia. Functional studies of the mouse ortholog Qk focused mainly on its role in oligodendrocyte development and myelination, while its function in astroglia remained unexplored. Here we show that ...
Qi Sheng - - 2013
Phase separation in pharmaceutical solid dispersion thin films under high humidity is still poorly understood on the sub-micron scale. This study investigated the phase separation of a model solid dispersion thin film, felodipine-PVP K29/32, prepared by spin-coating and analysed using probe based methods including atomic force microscopy (AFM), nano-thermal analysis ...
Bujan Bartosz - - 2013
Multiple system atrophy (MSA) is a rapidly progressive sporadic α-synucleinopathy with adult onset characterized by progressive cerebellar ataxia, basal ganglia symptoms, autonomic dysfunction and pyramidal tract signs. While full-blown dementia is considered an exclusion criterion according to Consensus Guidelines, mild cognitive deficits such as fronto-executive dysfunction have been reported in ...
Lee Li-Hui - - 2013
Personal Health Record systems (PHRs) provide opportunities for patients to access their own PHR. However, PHRs are teeming with medical terminologies, such as disease and symptom names, etc. Patients need readily understandable and useful health knowledge in addition to their records in order to enhance their self-care ability. This study ...
Szmigielski Stanislaw - - 2013
For years, radiofrequency (RF) and microwave (MW) radiations have been applied in the modern world. The rapidly increasing use of cellular phones called recent attention to the possible health risks of RF/MW exposures. In 2011, a group of international experts organized by IARC (International Agency for Research on Cancer in ...
Tvarijonaviciute A - - 2013
The objective of this study was to evaluate and compare different sample treatments and storage conditions in order to determine optimal conditions for total and acylated canine ghrelin measurement using ELISA assays. Under the conditions assessed in this study, total ghrelin concentration was stable when stored at room temperature or ...
Tuan Rocky S - - 2013
Tissue engineering and regenerative medicine have advanced rapidly towards the development of therapeutic solutions for musculoskeletal disorders. In 2012, breakthroughs have been made in the guidance of adult stem cell homing, the tissue regenerative activity of stem-cell-derived extracellular matrix has been tested, and novel, mechanically superior biomaterials have been fabricated.
Davis Michael A MA Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, - - 2013
The Mediator complex is an essential transcription regulator that bridges transcription factors with RNA polymerase II. This interaction is controlled by dynamic interactions between Mediator and the CDK8 module, but the mechanisms governing CDK8 module-Mediator association remain poorly understood. We show that Fbw7, a tumor suppressor and ubiquitin ligase, binds ...
Hruby Gregory William GW Department of Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. - - 2013
This paper describes our considerations and methods for implementing an open-source centralized research data repository (CRDR) and reports its impact on retrospective outcomes research capacity in the urology department at Columbia University. We performed retrospective pretest and post-test analyses of user acceptance, workflow efficiency, and publication quantity and quality (measured ...
Liu Chun-Ming - - 2013
In recent years, peptide hormones have been recognized as important signal molecules in plants. Genetic characterization of such peptides is challenging since they are usually encoded by small genes. As a proof of concept, we used the well-characterized stem cell-restricting CLV3 to develop an antagonistic peptide technology by transformations of ...
Kikuchi Azusa - - 2013
The excited states of UV-B absorber, 4-methylbenzylidenecamphor (MBC) have been studied through measurements of UV absorption, phosphorescence, triplet-triplet (T-T) absorption, and steady-state and time-resolved electron paramagnetic resonance spectra in ethanol. The energy level and lifetime of the lowest excited triplet (T1) state of MBC were determined. The energy level of ...
James Matthew T - - 2013
BACKGROUND: CONTRAST-INDUCED ACUTE KIDNEY INJURY (CI-AKI) HAS BEEN ASSOCIATED WITH MORTALITY, ALTHOUGH IT HAS BEEN SUGGESTED THIS ASSOCIATION MAY BE ATTRIBUTABLE TO CONFOUNDING. WE PERFORMED A SYSTEMATIC REVIEW AND META-ANALYSIS TO CHARACTERIZE THE ASSOCIATIONS BETWEEN CI-AKI AND SUBSEQUENT CLINICAL OUTCOMES.METHODS AND RESULTS: WE IDENTIFIED STUDIES USING MEDLINE (1950 TO JUNE ...
Wang Youbin - - 2013
Objective :  Minor cleft lip deformities are also called lesser-form cleft lips. A furrowed philtral column is one of the important characters of these deformities. Many surgical methods have been adopted to correct it with less than satisfactory results. In this article, a dermis reconstructive method was introduced. Patients :  ...
Sivanandan Sindhu - - 2013
Objective To compare the incidence of medical closure of patent ductus arteriosus (PDA) and adverse events (acute renal dysfunction, necrotizing enterocolitis, spontaneous intestinal perforation, and gastrointestinal bleeding) between preterm infants who received indomethacin and ibuprofen for the treatment of PDA.Study Design A retrospective comparative effectiveness evaluation study was conducted on preterm infants ...
Park Il-Kyoo IK Department of Microbiology, Virology, Immunology, and Medical Genetics, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, - - 2013
Approximately 20% to 25% of patients with acute myeloid leukemia (AML) have a constitutively activated FLT3-internal tandem duplication (FLT3-ITD), and these patients exhibit a poor prognosis. Here, we report that Axl, a receptor tyrosine kinase (RTK) overexpressed and constitutively active in human AML, targets the RTK FLT3 in FLT3-ITD(+) AML. ...
Romero Isabella S - - 2013
To produce conductive, biocompatible, and mechanically robust materials for use in bioelectrical applications, we have developed a new strategy to selectively incorporate poly(pyrrole) (Ppy) into constructs made from silk fibroin. Here, we demonstrate that covalent attachment of negatively charged, hydrophilic sulfonic acid groups to the silk protein can selectively promote ...
Calvo Veronica - - 2013
ABSTRACT: The local microenvironment influences tumor progression in several important ways. A recent study by Nguyen-Ngoc and colleagues used explants of primary human and mouse mammary tumors to examine how the composition of the extracellular matrix modulates tumor cell invasion. Culture in the presence of a three-dimensional laminin-rich basement membrane, ...
Stuetzer Bianca - - 2013
Feline leukaemia virus (FeLV) infection is still one of the leading causes of infection-related deaths in domestic cats. Treatment with various drugs has been attempted, but none has resulted in cure or complete virus elimination. Human interferon-α2a (huIFN-α2a) and 3'-azido-2',3'-dideoxythymidin (AZT) have been proven to decrease antigenaemia in cats infected ...
Chen Yu-An - - 2013
BACKGROUND: Semen analysis is essential for evaluating male infertility. Besides sperm concentration, other properties, such as motility and morphology, are critical indicators in assessing sperm quality. Nevertheless, rapid and complete assessment of these measures still presents considerable difficulty and involves a range of complex issues. Here we present a microfluidic ...
Charles Bimal - - 2013
Abstract HIV epidemic in India is predominantly concentrated in subgroups of population, such as female sex workers (FSWs) and their clients, whose behavior exposes them to a higher risk of acquiring HIV infection. This paper aims to present the changing patterns of socio-demographic characteristics, behaviors, reported sexually transmitted infections (STIs), ...
Meyer G - - 2013
Several studies have shown a reduced quality of life in patients with Addison's disease, but little is known about the potential influences.We determined the quality of life in 200 patients with Addison's disease using an Addison's disease-specific quality-of-life questionnaire. Data about first symptoms, time to diagnosis and current medication were ...
Ventosa-Andrés Pilar - - 2013
An efficient and environmentally friendly methodology for the solvent-free synthesis of α-amino nitrile derived ureas from α-amino acid based amino nitriles has been developed. At room temperature no epimerization was observed in the resulting ureas, but under microwave heating, epimerization occurred at the chiral center bearing the cyano group.
Kosaka Yoshimichi - - 2013
The outcomes of the swing-back technique for aortic arch repair during the arterial switch and Norwood operations are not well reported. Between May 2004 and January 2011, we performed this technique during the arterial switch and Norwood operations in 2 and 4 patients, respectively. The median (range) patient age and ...
Oćwieja Magdalena - - 2013
Systematic studies of particle deposition kinetics under diffusion transport on poly(allylamine hydrochloride) (PAH) modified mica were carried out using charge-stabilized, silver particle suspensions. Monolayer coverage, quantitatively determined by AFM and SEM, was regulated within broad limits by adjusting the nanoparticle deposition time and the ionic strength of deposition. The stability ...
Simonazzi G - - 2013
OBJECTIVE: To evaluate the outcome of pregnancies complicated by placental insufficiency and abnormal umbilical artery Doppler prior to viability. DESIGN: A retrospective cohort study. SETTING: Italy. POPULATION: Singleton pregnancies with fetal growth restriction and absence of end-diastolic velocities (AEDVs) in the umbilical arteries prior to 24 weeks. METHODS: A retrospective cohort ...
Tunc Burcu - - 2013
BACKGROUND AND OBJECTIVE: The thermal damage of the surrounding tissue can be an unwanted result of continuous-wave laser irradiations. In order to propose an effective alternative to conventional surgical techniques, photothermal damage must be taken under control by a detailed dose study. Real-time temperature monitoring can be also an effective ...
Poulie Christian B M - - 2013
Bioisosterism of α-amino acids is often accomplished by replacing the α-carboxylate with one of the many known carboxylic acid bioisosteres. However, bioisosterism of the whole α-amino acid moiety is accomplished with heterocyclic bioisosteres that often display an acidic function. In this Minireview, we summarized the reported heterocycles as nonclassical bioisosteres ...
Méndez-Acosta H O - - 2013
Efficient monitoring and control schemes are mandatory in the current operation of biological wastewater treatment plants because they must accomplish more demanding environmental policies. This fact is of particular interest in anaerobic digestion processes where the availability of accurate, inexpensive and suitable sensors for the on-line monitoring of key process ...
auf dem Keller Ulrich U Department of Oral Biological and Medical Sciences, 4.401 Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, - - 2013
During inflammation, vascular permeability is increased by various proteolytic events, such as the generation of bradykinin, that augment local tissue responses by enabling tissue penetration of serum proteins, including complement and acute-phase proteins. Proteases also govern inflammatory responses by processing extracellular matrix proteins and soluble bioactive mediators. We quantified changes ...
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