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Harris Jennifer L - - 2013
OBJECTIVE: Social marketing is commonly proposed to counteract advertising and other messages that promote unhealthy products. However, public service campaigns can also 'boomerang' or ironically increase the unhealthy behaviours they are designed to discourage. The present study examined whether antismoking public service announcements (PSAs) could increase smoking behaviour immediately following ...
Lovasi Gina S - - 2013
BACKGROUND: Urban landscape elements and trees in particular have the potential to affect airflow, air quality, and production of aeroallergens. Several large-scale urban tree planting projects have sought to promote respiratory health, yet evidence linking tree cover to human health is limited. OBJECTIVES: We sought to investigate the association of ...
Havla Joachim - - 2013
OBJECTIVE: Tumor necrosis factor (TNF) receptor 1-associated periodic syndrome (TRAPS) is an autoinflammatory disorder caused by autosomal dominantly inherited mutations in the TNF receptor superfamily 1A (TNFRSF1A) gene. The D12E substitution has been described only once to date, in a 4-year-old boy with fever. METHODS: For DNA sequence analysis of ...
Alsuwaidi Ahmed R - - 2013
ABSTRACT: BACKGROUND: Cellular bioenergetics (cellular respiration and accompanying ATP synthesis) is a highly sensitive biomarker of tissue injury and may be altered following infection. The status of cellular mitochondrial O2 consumption of the lung in pulmonary RSV infection is unknown. METHODS: In this study, lung fragments from RSV-infected BALB/c mice ...
Kamycheva Elena - - 2013
AIMS: The myocardium is considered to be an important target organ for parathyroid hormone and 1,25-dihydroxyvitamin D, the active metabolite of vitamin D. Vitamin D inadequacy has also been linked to cardiovascular morbidity. We aimed to evaluate the relationship between serum 25-hydroxyvitamin D [25(OH)D] and LV systolic function in a ...
Frost Michelle L - - 2013
The functional imaging technique of (18) F-fluoride positron emission tomography ((18) F-PET) allows the non-invasive quantitative assessment of regional bone formation at any skeletal site, including the spine and hip. The aim of this study was to determine if (18) F-PET can be used as an early biomarker of treatment ...
Sterud Tom - - 2013
AIMS: This study examines the impact of work-related psychosocial and mechanical exposure on the development of low back pain (LBP) in the general working population. METHODS: A randomly drawn cohort from the general population in Norway aged 18-66 years was followed up for 3 years (n=12 550, response rate at ...
van der Gronde Toon - - 2013
The possibility of gene doping, defined as the transfer of nucleic acid sequences and/or the use of normal or genetically modified cells to enhance sport performance, is a real concern in sports medicine. The abuse of knowledge and techniques gained in the area of gene therapy is a form of ...
Jorquera Gonzalo - - 2013
An important pending question in neuromuscular biology is how skeletal muscle cells decipher the stimulation pattern coming from motoneurons to define their phenotype as slow or fast twitch muscle fibers. We have previously shown that Cav1.1 acts as a voltage sensor for activation of IP(3)-dependent Ca(2+) signals that regulate gene ...
Jourdan Eric - - 2013
Not all the patients with CBF-AML display a good outcome. Modern risk factors include KIT and/or FLT3 gene mutations and MRD levels, but their respective values have never been prospectively assessed. One hundred ninety-eight CBF-AML patients were treated in this French Intergroup CBF-2006 trial. They were randomized between a reinforced ...
Hashimoto Muneaki - - 2013
In animals, inositol 1,4,5-trisphosphate receptors (IP(3) Rs) are ion channels that play a pivotal role in many biological processes by mediating Ca(2+) release from the endoplasmic reticulum. Here, we report the identification and characterization of a novel IP(3) R in the parasitic protist, Trypanosoma cruzi, the pathogen responsible for Chagas ...
Tanboon Jantima - - 2013
IgG4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory condition which often shows a dramatic response to steroid therapy. IgG4-RD can present either as a single lesion or as a systemic multi-organ disorder. Common histological findings include a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and phlebitis. Although ...
Down Matthew - - 2013
ABSTRACT: BACKGROUND: Previous studies have suggested that the axon guidance proteins Slit1 and Slit2 co-operate to establish the optic chiasm in its correct position at the ventral diencephalic midline. This is based on the observation that, although both Slit1 and Slit2 are expressed around the ventral midline, mice defective in ...
Cuny Thomas - - 2013
CONTEXT: germline mutations in the AIP gene have been identified in young patients (age ≤ 30 years old) with sporadic pituitary macroadenomas. Otherwise, there are few data concerning the prevalence of MEN1 mutations in such population. OBJECTIVE: We assessed the prevalence of both AIP and MEN1 genetic abnormalities (mutations and ...
Yang Mingyu - - 2013
Palladium-catalyzed direct lactonization of 2-arylacetic acids through a reaction sequence that includes C-H activation/C-O formation is reported. This method provides a concise and efficient pathway to synthesize fully functionalized benzofuranone derivatives, which are highly relevant to bioactive natural and synthetic products.
Wang Shuai - - 2013
Antigen receptor engagement triggers lymphocyte activation and proliferation by activating several transcription factors including NF-κB. Caspase recruitment domain (CARD)-containing membrane-associated guanylate kinase (MAGUK) protein1 (CARMA1) is an essential adaptor protein that links antigen receptors to NF-κB activation. Here, we identify stress-induced-phosphoprotein 1 homology and U-box containing protein 1 (STUB1) as ...
Radosa Mp - - 2013
OBJECTIVE: To evaluate laparoscopic lymphocele fenestration (LLF) as a first-line treatment in gynaecological cancer patients with a history of retroperitoneal lymph node dissection (LND). DESIGN: Retrospective cohort study. SETTING: A tertiary referral centre. POPULATION: Patients who underwent LLF between January 2001 and December 2010 for a symptomatic lymphocele following retroperitoneal ...
Jones Roanne R - - 2013
The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C16-KTTKS is investigated, and related to its self-assembly into nanotapes structures. This PA is used in anti-wrinkle cosmeceutical applications (tradename MatrixylTM). We prove that C16-KTTKS stimulates collagen production in a concentration-dependent manner ...
Behnes Carl Ludwig - - 2013
ABSTRACT: BACKGROUND: Papillary renal cell carcinoma is a rare cancer. Some cases can be attributed to individuals with hereditary renal cell carcinomas usually consisting of the clear cell subtype. In addition, two syndromes with hereditary papillary renal cell carcinoma have been described. One is the hereditary leiomyomatosis and renal cell ...
Sánchez Francisco J - - 2013
In April 2011, the International Olympic Committee (IOC) and the International Association of Athletics Federations (IAAF) updated their regulations regarding elite female athletes with hyperandrogenism: Women whose testosterone levels crossed into the male range could not compete with other women unless it was shown that they are resistant to the ...
Koeman Tom - - 2013
OBJECTIVES: Although a study among utility workers found an increased risk for acute myocardial infarction and arrhythmia-related deaths associated with occupational extremely low-frequency magnetic fields (ELF-MF) exposure, later studies largely failed to replicate these findings. This study investigated the association between occupational ELF-MF exposure and cardiovascular disease (CVD) mortality within ...
Alvarez Enrique - - 2013
CXCL13, a B-cell chemokine, has been proposed as a biomarker in a variety of conditions, some of which can mimic multiple sclerosis and can have very high levels. In this case-control study, cerebrospinal fluid (CSF) CXCL13 was elevated in multiple sclerosis, neuromyelitis optica and other inflammatory neurological controls compared with ...
Semb Anne G - - 2013
OBJECTIVE: Carotid plaques (CP) are predictive of acute coronary syndrome in patients with rheumatoid arthritis (RA), suggesting that atherosclerotic plaques in these patients are vulnerable. The objective of our study was to characterize vulnerability of CP in patients with RA compared to a control population, and between RA patients with ...
Yang Xiaoling - - 2013
A facile strategy to synthesize the novel composite paper of graphene nanosheets (GNS) coated Co3O4 fibers is reported as an advanced anode material for high-performance lithium-ion batteries (LIBs). The GNS were able to deposit onto Co3O4 fibers and form the coating via electrostatic interactions. The unique hybrid paper is evaluated ...
Xiao Fei - - 2013
WSS25 is a sulfated polysaccharide which inhibits angiogenesis. However, the mechanism underlying the regulation of angiogenesis by WSS25 is not well understood. Using microRNA (miRNA) microarray analysis, a total of 25 miRNAs were found to be upregulated and 12 (including miR-210) downregulated by WSS25 in human microvascular endothelial cells (HMEC-1). ...
Yang Zhu-Lin - - 2013
Cofilin-1 (CFL1) and Arp3 expression in 46 squamous cell and adenosquamous carcinomas (SC/ASCs) and 80 adenocarcinomas (ACs) were measured by using immunohistochemistry. Positive CFL1 and Arp3 expression were significantly associated with large tumor size, high TNM stage, lymph node metastasis, and decreased overall survival in both SC/ASC and AC patients ...
Wouters Hanne - - 2013
Abstract Objective To assess the cost-effectiveness of dabigatran etexilate ('dabigatran') versus vitamin K antagonists (VKAs) in the Belgian healthcare setting for the prevention of stroke and systemic embolism (SE) in patients with non-valvular atrial fibrillation (AF). Research design and methods A Markov model was used to calculate the cost-effectiveness of ...
Kifer Yona - - 2013
A common cliché and system-justifying stereotype is that power leads to misery and self-alienation. Drawing on the power and authenticity literatures, however, we predicted the opposite relationship. Because power increases the correspondence between internal states and behavior, we hypothesized that power enhances subjective well-being (SWB) by leading people to feel ...
Damián Javier - - 2013
ABSTRACT: BACKGROUND: Falls have enormous impact in older adults. Yet, there is insufficient evidence regarding the effectiveness of preventive interventions in this setting. The objectives were to measure the frequency of falls and associated factors among older people living institutions. METHODS: Data were obtained from a survey on a probabilistic ...
Evans Catherine J - - 2013
Background:Improved and cost-effective palliative and end-of-life care is an international policy imperative. Developments are impeded by a weak and often inconsistent evidence base.Aim:To examine the main methodological challenges and limitations to developing and evaluating palliative and end-of-life care services and requirements to further this field of research.Design:A meta-synthesis to systematically ...
Zhu Haiyan - - 2013
Although many patients with duplication 3q syndrome have been described reports on duplication derivatives from an insertion are rare in the previous literature. Here we describe the genotype and phenotype of a 32-month-old boy with a partial trisomy of 3q24-q28. We carefully mapped the aberration with SNP-array analysis, and found ...
Zhang Jing - - 2013
BACKGROUND: Patients with lung cancer are at high risk of venous thromboembolism (VTE), and VTE predicts a poor prognosis. Anticoagulation therefore might be beneficial for these patients. It is not clear whether anticoagulants could improve survival and other outcomes in patients with lung cancer with no indication for anticoagulation. METHODS: ...
Dasilva Jack G - - 2013
Magnetization as a function of applied pressure up to 10.16 kbar and magnetic field were obtained for layered [Ru(2)(O(2)CBu(t))(4)](3)[M(CN)(6)]·2H(2)O (M = Cr, Fe). For M = Fe, the T(c) increased by 13% from 6.1 to 6.9 K with a significant increase in the coercive field, H(cr), from 5 to 65 ...
Radhakrishnan Karthikeyan - - 2013
The AP-1 complex recycles between membranes and the cytoplasm and dissociates from membranes during clathrin-coated-vesicle uncoating, but also independent of vesicular transport. The μ1A N-terminal seventy amino acids are involved in regulating AP-1 recycling. In a yeast-2-hybrid library screen we identified the cytoplasmic prolyl-oligopeptidase-like protein PREPL as an interaction partner ...
Sharma Satyan - - 2013
The T cell receptor (TCR) together with accessory Cluster of differentiation 3 (CD3) molecules (TCR-CD3 complex) is a key component in the primary function of T cells. The nature of association of the transmembrane domains is of central importance to the assembly of the complex and is largely unknown. Using ...
Jones Richard K - - 2013
OBJECTIVE: Few if any prevention strategies are available for knee osteoarthritis (OA). In those with symptomatic medial OA, the contralateral knee may be at high risk of disease, and a reduction in medial loading in that knee might prevent disease or its progression there. Our aim was to determine how ...
Wasano Koichiro - - 2013
Abstract Conclusion: The Japanese version of the Tinnitus Handicap Inventory-12 (THI-12), Tinnitus Rating Scale (TRS), TRS 1-week version (TRSw), Tinnitus Severity Scale (TSS), and TSS 1-week version (TSSw), which were developed in this study, showed high reliability and validity, suggesting their usefulness in clinical practice. Based on the THI severity ...
Larsen Alf Inge - - 2013
AIMS: We evaluated the effects of cardiac resynchronization therapy (CRT) on skeletal muscle pathology and inflammation in patients with heart failure.METHODS AND RESULTS: Stable patients (n = 21, 14 males, mean age 70 ± 7 years) with symptomatic heart failure (mean left ventricular ejection fraction 24 ± 6%) and an ...
Veraitch Ophelia - - 2013
Well-orchestrated epithelial-mesenchymal interactions are crucial for hair follicle (HF) morphogenesis. In this study, ectodermal precursor cells (EPCs) with the capacity to crosstalk with hair inductive dermal cells were generated from human induced pluripotent stem cells (hiPSCs) and assessed for HF forming ability in vivo. EPCs derived from three hiPSC lines ...
Powar Mp - - 2013
AIM: Laparoscopic ventral rectopexy (LVR) is a non-resectional technique for selected patients with full thickness rectal prolapse and obstructed defecation syndrome. Despite its challenges, LVR can be performed with relatively minimal patient trauma thus creating the potential for same-day discharge. Our aim was to assess the safety of day-case LVR ...
Ralib Azrina M - - 2013
Aims: Treatment of renal anemia with erythropoietic stimulating agents sometimes increases blood pressure. It is uncertain whether this is due to direct vasoconstriction and/or increased red blood cell mass. Materials and methods: We conducted a post-hoc analysis of 160 critically ill patients in the EARLYARF trial with elevated urinary γ-glutamyltranspeptidase ...
Agostini Michela - - 2013
OBJECTIVE: To investigate whether a refined assessment of exposure to bitumen fume among workers in the European asphalt industry within a nested case-control study resulted in a different interpretation pertaining to risk of lung cancer mortality compared with the cohort study. METHODS: Pearson correlation coefficients between refined and original estimates ...
Abe Sofie - - 2013
Various literature studies show that increasing the concentration of free acid in the hot injection synthesis raises the diameter of the resulting nanocrystals. We analyze this reaction chemistry/nanocrystal property relation by combining reaction simulations with an experimental study on a particular CdSe QD synthesis. We find that increasing the free ...
Nishida Sachiyo - - 2013
Prostate cancer cells include a small population of cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) that have roles in initiation and progression of the cancer. Recently, we isolated prostate CSCs/CICs as aldehyde dehydrogenase 1-highh (ALDH1(high) ) cells using the ALDEFLUOR assay; however, the molecular mechanisms of prostate CSCs/CICs are still elusive. ...
Aragón-Sánchez J - - 2013
Some experimental data in well-established rat models suggest that elevated tumour necrosis factor (TNF)-α levels may be directly related to histopathological changes during osteomyelitis [1]. Local release of interleukin-6 (IL-6) is also increased in bacterial osteomyelitis [2]. However, no data about local release of IL-6 and TNF-α in cases of ...
Head Elizabeth Nicole - - 2013
OBJECTIVE: To quantify and describe non-fatal, unintentional bathroom injuries among children less than 15 years of age treated in US hospital emergency departments (EDs). METHODS: This study used 2008 data from a nationally representative sample of EDs, available from the National Electronic Injury Surveillance System-All Injury Program. We examined unintentional ...
Zhang Junrui - - 2013
Phytochromes (phys) encompass a diverse collection of biliproteins that enable cellular light perception by photoconverting between a red-light-absorbing ground state - Pr and a far-red light-absorbing active state - Pfr. Based on the central role of plant phys in controlling numerous agriculturally important processes, their rational redesign offers great promise ...
Takino Hisashi - - 2013
Abstract Although rare, thymic mucosa-associated lymphoid tissue (MALT) lymphoma is considered to be a distinct clinicopathological entity. Using a methylation-specific polymerase chain reaction, we analyzed thymic MALT lymphomas (n=18) for their methylation of the following seven tumor suppressor genes: DAPK1, p16(INK4A), p14(ARF), CDH1, RARB, TIMP3, and MGMT. Reactive lymph nodes ...
Bergethon Peter R - - 2013
In normal development and pathology, the vascular system depends on complex interactions between cellular elements, biochemical molecules, and physical forces. The electrokinetic vascular streaming potential (EVSP) is an endogenous extremely low frequency (ELF) electrical field resulting from blood flowing past the vessel wall. While generally unrecognized, it is a ubiquitous ...
Huang Feiran - - 2013
In this paper, we compared the minimum potential differences in the electroporation of membrane lipid bilayers and the denaturation of membrane proteins in response to an intensive pulsed electric field with various pulse durations. Single skeletal muscle fibers were exposed to a pulsed external electric field. The field-induced changes in ...
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