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Results 601 - 650 of 2384
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Leone Antonio Maria - - 2013
BACKGROUND: FRACTIONAL FLOW RESERVE (FFR) SPECIFICALLY RELATES TO THE SEVERITY OF A STENOSIS TO THE MASS OF TISSUE TO BE PERFUSED. ACCORDINGLY, THE LARGER THE TERRITORY TO BE PERFUSED, THE GREATER THE FLOW AND THE PRESSURE GRADIENT INDUCED BY MAXIMAL HYPEREMIA. ALTHOUGH THIS NOTION MAY BE CONSIDERED INTUITIVE, ITS UNEQUIVOCAL ...
Bilandzic Maree - - 2013
The molecular pathways controlling granulosa cell tumor (GCT) survival are poorly understood. In many cell types, nuclear factor-κB (NFκB) and TGFβ coordinately regulate cell survival to maintain tissue homeostasis. Because GCT cell lines exhibit constitutively activated NFκB, we hypothesized that NFκB blocks TGFβ-mediated cell death in GCT cells. To test ...
Patel Hasmukh A - - 2013
Post-combustion CO(2) capture and air separation are integral parts of the energy industry, although the available technologies remain inefficient, resulting in costly energy penalties. Here we report azo-bridged, nitrogen-rich, aromatic, water stable, nanoporous covalent organic polymers, which can be synthesized by catalyst-free direct coupling of aromatic nitro and amine moieties ...
Li Z - - 2013
AIMS: Consumption of a high-fat diet has been demonstrated to promote endothelial dysfunction, possibly through an increase in lipid peroxidation and decrease in serum nitric oxide. The present study was designed to investigate whether consumption of a hamburger patty cooked with a polyphenol-rich spice mixture will reduce postprandial lipid oxidation ...
Iskandar Aline - - 2013
BACKGROUND: The aorta is exposed to hemodynamic stress during exercise, but whether or not the aorta is larger in athletes is not clear. We performed a systematic literature review and meta-analysis to examine if athletes demonstrate increased aortic root dimensions when compared to non-athlete controls. METHODS AND RESULTS: We searched ...
Moradi-Lakeh Maziar - - 2013
PURPOSE: We performed this study to assess the trend of geographical disparities between rural areas located in the catchment areas of 41 medical universities in Iran from 1993 to 2008. We evaluated four indicators including rates for neonatal mortality (NMR), infant mortality (IMR), under-5 mortality (U5MR) and crude death (CDR). ...
Sankaranarayanan Kamatchi - - 2013
This study reports on the helix-beta conformation of bovine beta lactoglobulin (LG) prepared at two different pH conditions (pH=4 and 7.5), and in the presence of an ionic liquid 1-ethyl 3-methyl imidazolium ethyl sulfate (IL-emes). The investigation was carried out by combining a range of techniques such as circular dichroic ...
Ying Gui-Shuang - - 2013
BACKGROUND: In clinical trials with time-to-event outcomes, it is common to design the interim analysis plan around the occurrence of designated target numbers of events. As the trial progresses, one may wish to use the accumulating data to predict the calendar times of these events as an aid to logistical ...
Alexandre Virginie - - 2013
Lactose malabsorption is associated with rapid production of high levels of osmotic compounds, such as organic acids and SCFA in the colon, suspected to contribute to the onset of lactose intolerance. Adult rats are lactase deficient and the present study was conducted to evaluate in vivo the metabolic consequences of ...
Macgowan Stuart A - - 2013
A facile, experimentally calibrated computational procedure is described that affords the relative ordering of heme cofactor reduction potentials with respect to intrinsic shifts brought about by apoprotein induced heme-macrocycle distortion. The method utilizes heme-Fe partial atomic charges and is useful with the computationally inexpensive B3LYP/3-21g method calculated for simplified heme ...
Hua Jessica - - 2013
Insecticide tolerance and cross-tolerance in nontarget organisms is often overlooked despite its potential to buffer natural systems from anthropogenic influence. The authors exposed wood frog tadpoles from 15 populations to three acetylcholine esterase-inhibiting insecticides and found widespread variation in insecticide tolerance and evidence for cross-tolerance to these insecticides. The present ...
Prendes Mark A - - 2013
Glaucoma is a progressive optic neuropathy frequently associated with elevated intraocular pressure, ocular vascular changes and extracellular matrix remodelling at the optic nerve head and in the trabecular meshwork. The pathogenesis is multifactorial and complex, but many recent studies have suggested that transforming growth factor-β (TGF-β) plays a major role ...
Howe Laura D - - 2013
BACKGROUND: Socioeconomic inequalities are a key policy challenge. Studies to date have not taken a unified approach to assess how socioeconomic inequalities in health, behaviour and educational attainment change as children age. METHODS: We examined maternal education inequalities in multiple offspring health, behavioural and educational outcomes and how these changed ...
Russo Ricardo A G - - 2013
OBJECTIVE: Systemic juvenile idiopathic arthritis (SJIA) frequently leads to disability and damage. Predictive factors for a poor outcome include persistent systemic features and younger age at onset. We describe and analyze disease features in patients with early-onset (EO) SJIA (disease onset before age 18 mo) and compare them to patients ...
Kansagra Akash P - - 2013
BACKGROUND: The role of catheter angiography in the diagnosis and management of traumatic cerebrovascular injury has evolved rapidly with advances in CT and MR angiography and continued development of endovascular techniques. OBJECTIVE: To identify the modern spectrum of traumatic arterial injury encountered during catheter neuroangiography and to examine current patterns ...
Pandey Lila B - - 2013
Interaction of lactic acid with various sizes of magnesium oxide clusters (MgO)(x) (x = 2, 4, 6, 8, 9, 12, 15, 16, 18) is investigated. Density functional theory with the PBE functional and a polarized double-ζ basis set is employed to optimize the structures. For MgO dimer, optimizations are also ...
Zhao Qianhua - - 2013
The verbal fluency test (VFT) can be dissociated into "clustering" (generating words within subcategories) and "switching" (shifting between clusters), which may be valuable in differential diagnosis. In the current study, we investigated the validity of VFT in the differential diagnosis of Alzheimer's disease (AD, n = 65), vascular dementia (VaD, ...
Datta Payel - - 2013
Chinese hamster ovarian cells (CHO) cells have been extensively utilized for industrial production of biopharmaceutical products, such as monoclonal antibodies, human growth hormones, cytokines, and blood-products. Recent advances in recombinant DNA technology have resulted in the bioengineering of CHO cells that have robust gene amplification systems and can also be ...
Igbinosa Isoken H - - 2013
The detection of genes responsible for Aeromonas virulence is a vital tool in establishing the potential pathogenicity of the bacteria, as these virulence genes may act alone or in synergy in the establishment of infections. Freshwater and wastewater mixed liquor samples were collected from Kat river and Fort Beaufort wastewater ...
Scheve Christine S - - 2013
Cellular membranes are densely crowded with a diverse population of integral and membrane associated proteins. In this complex environment, lipid rafts, which are phase-separated membrane domains enriched in cholesterol and saturated lipids, are thought to organize the membrane surface. Specifically, rafts may help to locally concentrate proteins and lipids, enabling ...
Dawson Samantha J - - 2013
Introduction.  Laboratory studies have revealed two well-replicated sex differences in sexual arousal patterns: category specificity and sexual concordance. Men's genital responses are dependent on specific sexual cues and are concordant with subjective reports of arousal. Women's genital responses are much less dependent on specific sexual cues and are much less ...
Li Fushuang - - 2013
Polyflavanostilbene A, a new flavanol-fused stilbene glycoside, was isolated from the rhizome of Polygonum cuspidatum. Its unusual structure, including its absolute stereochemistry, was determined by UV, IR, HRESIMS, and 1D and 2D NMR data and by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Polyflavanostilbene A has ...
Jiang Yi - - 2013
Recently, tandem repeat typing has emerged as a rapid and easy method for the molecular epidemiology of the Mycobacterium tuberculosis (M. tuberculosis) complex. In this study, a collection of 19 VNTRs incorporating 15 previously described loci and 4 newly evaluated markers were used to genotype 206 Chinese M. tuberculosis isolates ...
Gresback Ryan - - 2013
We investigate the size-dependent optical extinction properties of colloidal Si NCs from the near-IR to UV. Experimental results are compared to the Mie solution to Maxwell's equations using the same refractive index as bulk Si in order to evaluate the deviation from bulk properties. We find that the energy for ...
Brichetto Giampaolo - - 2013
Improvement of sensory strategies is a relevant part of balance rehabilitation in multiple sclerosis (MS). This study aimed to Assess the effectiveness of visual-feedback exercises in improving balance in MS. We divided 36 patients into Wii and control-treated groups that underwent balance rehabilitation. Outcomes were obtained for Berg Balance Scale ...
Naredo Esperanza - - 2013
OBJECTIVE: To assess the responsiveness and repeatability of volumetric power Doppler ultrasound (PDUS) evaluation of synovitis and bone erosions in rheumatoid arthritis (RA). METHODS: Twenty-three patients with RA (19 women, mean age 52.7 ± 12.6 yrs, mean disease duration 10.1 ± 8.6 yrs) were prospectively enrolled. All patients were beginning ...
Violante Sara - - 2013
Acylcarnitines are commonly used in the diagnosis of mitochondrial fatty acid β-oxidation disorders (mFAODs). It is generally assumed that this plasma acylcarnitine profile reflects the mitochondrial accumulation of acyl-CoAs. The identity of the enzymes and the mitochondrial and plasmalemmal transporters involved in the synthesis and export of these metabolites have ...
Nemoto Tetsuhiro - - 2013
Inspiroation: A novel synthesis of spirocycles based on a palladium-catalyzed intramolecular ipso-Friedel-Crafts alkylation of phenols (see scheme; dba=dibenzylideneacetone) and indoles is described. Mechanistic studies show that the reaction proceeds through an unprecedented rearomatization-assisted oxidative addition.
Henning Armin - - 2013
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Urothelial carcinoma of the bladder (UCB) is more prevalent in men than women; however, in women the tumour stage is generally more advanced at the time of the diagnosis and the prognosis is worse. Possible explanations include anatomical, genetic ...
Poliakoff Ellen - - 2013
People with Parkinson's disease (PD) exhibit slowed movements and difficulty in initiating movements. This review addresses the issue of whether or not cognitive representations of actions in PD are affected, alongside these motor problems. In healthy people, the motor system can be involved in tasks such as observing a graspable ...
Xu Yang - - 2013
Carbon dots (Cdots) are an important probe for imaging and sensing applications because of their fluorescence property, good biocompatibility, and low toxicity. However, complex procedures and strong acid treatment are often required and Cdots suffer from low photoluminescence (PL) emission. Herein, a facile and general strategy using carbonization of precursors ...
Frosch Torsten - - 2013
Highly sensitive Raman gas spectroscopy is introduced for simultaneous real time analysis of O(2), CO(2), CH(4), and N(2) in order to elucidate the dynamics of greenhouse gases evolving from climate-sensitive ecosystems. The concentrations and fluxes of this suite of biogenic gases were quantified in the head space of a water-saturated, ...
Lütjens Götz - - 2013
Pneumocephalus may occur after intracranial surgery and is most often asymptomatic. It is usually associated with posterior fossa surgery. Here, we present a 56-year-old man who developed akinetic mutism and parkinsonism caused by subdural and intraventricular tension pneumocephalus associated with decompression of a chronic subdural hygroma. As an emergency treatment, ...
Baig Mirza Mansoor - - 2013
Health monitoring systems have rapidly evolved during the past two decades and have the potential to change the way health care is currently delivered. Although smart health monitoring systems automate patient monitoring tasks and, thereby improve the patient workflow management, their efficiency in clinical settings is still debatable. This paper ...
Wynant Willy - - 2013
OBJECTIVES: We investigated the association between workplace lead exposure and lung cancer risk, separately for organic lead and for inorganic lead, from either engine emissions or from other sources. METHODS: Two population-based case-control studies were carried out in Montreal (1979-1986 and 1996-2002) to investigate occupational factors in relation to lung ...
Tasdelen Ismayil - - 2013
Reversible phosphorylation is a widespread molecular mechanism to regulate the function of cellular proteins, including transcription factors. Phosphorylation of the nuclear receptor Peroxisome Proliferator Activated Receptor γ (PPARγ)on two conserved serine residue (S112 and S273) results in altered transcriptional activity of this transcription factor. So far, only a very limited ...
Spencer Liam P - - 2013
Synthetic routes to salts containing uranium bis-imido tetrahalide anions [U(NR)(2)X(4)](2-) (X = Cl(-), Br(-)) and non-coordinating NEt(4)(+) and PPh(4)(+) countercations are reported. In general, these compounds can be prepared from U(NR)(2)I(2)(THF)(x) (x = 2 and R = (t)Bu, Ph; x = 3 and R = Me) upon addition of excess ...
Khanna Swati - - 2013
Glycerol, the principal byproduct of biodiesel production, can be a valuable carbon source for bioconversion into diverse class of compounds. This paper attempts to investigate the mechanistic aspects of ultrasound mediated bioconversion of glycerol to ethanol and 1,3-propanediol (1,3-PDO) by immobilized Clostridium pasteurianum cells on silica support. Our approach is ...
Betts Julia N - - 2013
While conducting toxicity tests with nano titanium dioxide, the authors found that test suspensions were being contaminated with aluminum and titanium from tip erosion during direct sonication. The contaminating alloy particles had a measurable size distribution and zeta potential using dynamic light scattering, which changed the measured characteristics of the ...
Becks Lutz - - 2013
Stability and persistence of populations is of great interest for management and conservation purposes. Spatial dynamics can have a crucial role in population stability via synchronization, and beneficial and detrimental effects on population persistence have been shown. Despite a theoretical understanding of synchronization, empirical data on synchrony of populations are ...
Iyen-Omofoman Barbara - - 2013
INTRODUCTION: In the UK, most people with lung cancer are diagnosed at a late stage when curative treatment is not possible. To aid earlier detection, the socio-demographic and early clinical features predictive of lung cancer need to be identified. METHODS: We studied 12 074 cases of lung cancer and 120 ...
Zhao Weixiong - - 2013
Despite the significant progress in the measurements of aerosol extinction and absorption using spectroscopy approaches such as cavity ring down spectroscopy (CRDS) and photoacoustic spectroscopy (PAS), the widely used single wavelength instruments may suffer from the interferences of gases absorption present in the real environment. A second instrument for simultaneous ...
Konofaos Petros - - 2013
Promoting neurological recovery requires strategies that simultaneously provide protection to injured neurons and increase the numbers of neurons that extend axons while inducing more rapid and extensive axon regeneration across long nerve gaps. An agent that facilitates the speed and success of reinnervation will have direct applicability to the clinical ...
Leary Sam D - - 2013
BACKGROUND: A recent review found little evidence for substantial effects of modifiable maternal exposures on offspring blood pressure (BP), but this may have been because almost all the studies reported on BP in early and mid-childhood. METHODS: This study uses data on 4723 mother-child pairs, collected as part of the ...
Fleischmann Roy M - - 2013
OBJECTIVE: To assess radiographic progression, physical function, clinical disease activity, and safety in patients with rheumatoid arthritis (RA) who had inadequate response to methotrexate (MTX) and who were treated with tocilizumab-MTX or MTX during Year 2 of a 2-year study. METHODS: During Year 1, patients were randomized to placebo-MTX, 4 ...
Wei Zuo-Fu - - 2013
In this study, the effect of UV irradiation (UV-A, UV-B and UV-C) on phytochemicals, total phenolics and antioxidant activity of postharvest pigeon pea leaves were evaluated. The response of pigeon pea leaves to UV irradiation was phytochemical-specific. UV-B and UV-C induced higher levels of phytochemicals, total phenolics and antioxidant activity ...
McLeod Monsey Chan - - 2013
BACKGROUND: Medication administration errors (MAEs) are a problem, yet methodological variation between studies presents a potential barrier to understanding how best to increase safety. Using the UK as a case-study, we systematically summarised methodological variations in MAE studies, and their effects on reported MAE rates. METHODS: Nine healthcare databases were ...
Deng Ling - - 2013
Recent studies on CRISPR-based adaptive immune systems have revealed extensive structural and functional diversity of the interference complexes which often coexist intracellularly. The archaeon Sulfolobus islandicus REY15A encodes three interference modules, one of type IA and two of type IIIB. Earlier we showed that type IA activity eliminated plasmid vectors ...
Nishi Rie - - 2013
Cytarabine (ara-C) is the key agent for treating acute myeloid leukemia. After being transported into leukemic cells, ara-C is phosphorylated, by several enzymes including deoxycytidine kinase (dCK), to ara-C triphosphate (ara-CTP), an active metabolite, and then incorporated into DNA, thereby inhibiting DNA synthesis. Therefore, the cytotoxicity of ara-C depends on ...
Andoy Nesha May - - 2013
Shape-controlled metal nanocrystals are a new generation of nanoscale catalysts. Depending on their shapes, these nanocrystals exhibit various surface facets, and the assignments of their surface facets have routinely been used to rationalize or predict their catalytic activity in a variety of chemical transformations. Recently we discovered that for 1-dimensional ...
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