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Dasilva Jack G - - 2013
Magnetization as a function of applied pressure up to 10.16 kbar and magnetic field were obtained for layered [Ru(2)(O(2)CBu(t))(4)](3)[M(CN)(6)]·2H(2)O (M = Cr, Fe). For M = Fe, the T(c) increased by 13% from 6.1 to 6.9 K with a significant increase in the coercive field, H(cr), from 5 to 65 ...
Feldmanhall Oriel - - 2013
Research has illustrated that the brain regions implicated in moral cognition comprise a robust and broadly distributed network. However, understanding how these brain regions interact and give rise to the complex interplay of cognitive processes underpinning human moral cognition is still in its infancy. We used fMRI to examine patterns ...
Radhakrishnan Karthikeyan - - 2013
The AP-1 complex recycles between membranes and the cytoplasm and dissociates from membranes during clathrin-coated-vesicle uncoating, but also independent of vesicular transport. The μ1A N-terminal seventy amino acids are involved in regulating AP-1 recycling. In a yeast-2-hybrid library screen we identified the cytoplasmic prolyl-oligopeptidase-like protein PREPL as an interaction partner ...
Cadieux Brigitte B Michael Smith Laboratories and Department of Microbiology and Immunology, The University of British Columbia, Vancouver, BC, - - 2013
Iron acquisition is critical for virulence of the human pathogenic fungus Cryptococcus neoformans. The cryptococcal transcript for the extracellular mannoprotein Cig1 is highly regulated by iron and abundant in iron-starved cells, suggesting a role in iron acquisition. Indeed, loss of Cig1 resulted in delayed growth on heme at physiological pH. ...
Sharma Satyan - - 2013
The T cell receptor (TCR) together with accessory Cluster of differentiation 3 (CD3) molecules (TCR-CD3 complex) is a key component in the primary function of T cells. The nature of association of the transmembrane domains is of central importance to the assembly of the complex and is largely unknown. Using ...
Jones Richard K - - 2013
OBJECTIVE: Few if any prevention strategies are available for knee osteoarthritis (OA). In those with symptomatic medial OA, the contralateral knee may be at high risk of disease, and a reduction in medial loading in that knee might prevent disease or its progression there. Our aim was to determine how ...
Procopio G - - 2013
Elderly patients tend to be underrepresented in renal cell carcinoma (RCC) clinical trials. The Sorafenib RCC Integrated Database includes data from six clinical trials and two expanded-access studies evaluating sorafenib monotherapy in >4600 patients with RCC. Using this database, sorafenib tolerability and treatment patterns were analysed according to age group ...
Wasano Koichiro - - 2013
Abstract Conclusion: The Japanese version of the Tinnitus Handicap Inventory-12 (THI-12), Tinnitus Rating Scale (TRS), TRS 1-week version (TRSw), Tinnitus Severity Scale (TSS), and TSS 1-week version (TSSw), which were developed in this study, showed high reliability and validity, suggesting their usefulness in clinical practice. Based on the THI severity ...
Larsen Alf Inge - - 2013
AIMS: We evaluated the effects of cardiac resynchronization therapy (CRT) on skeletal muscle pathology and inflammation in patients with heart failure.METHODS AND RESULTS: Stable patients (n = 21, 14 males, mean age 70 ± 7 years) with symptomatic heart failure (mean left ventricular ejection fraction 24 ± 6%) and an ...
Veraitch Ophelia - - 2013
Well-orchestrated epithelial-mesenchymal interactions are crucial for hair follicle (HF) morphogenesis. In this study, ectodermal precursor cells (EPCs) with the capacity to crosstalk with hair inductive dermal cells were generated from human induced pluripotent stem cells (hiPSCs) and assessed for HF forming ability in vivo. EPCs derived from three hiPSC lines ...
Powar Mp - - 2013
AIM: Laparoscopic ventral rectopexy (LVR) is a non-resectional technique for selected patients with full thickness rectal prolapse and obstructed defecation syndrome. Despite its challenges, LVR can be performed with relatively minimal patient trauma thus creating the potential for same-day discharge. Our aim was to assess the safety of day-case LVR ...
Ralib Azrina M - - 2013
Aims: Treatment of renal anemia with erythropoietic stimulating agents sometimes increases blood pressure. It is uncertain whether this is due to direct vasoconstriction and/or increased red blood cell mass. Materials and methods: We conducted a post-hoc analysis of 160 critically ill patients in the EARLYARF trial with elevated urinary γ-glutamyltranspeptidase ...
Papadopulos A S T - - 2013
On Lord Howe Island, speciation is thought to have taken place in situ in a diverse array of distantly related plant taxa (Metrosideros, Howea and Coprosma; Proc. Natl Acad. Sci. USA 108, 2011, 13188). We now investigate whether the speciation processes were driven by divergent natural selection in each genus ...
Schmidt V - - 2013
Respiratory diseases in boid snakes are common in captivity, but little information is available on their aetiology. This study was carried out to determine the occurrence of lung associated pathogens in boid snakes with and without respiratory signs and/or pneumonia. In total, 80 boid snakes of the families Boidae (n = 30) ...
Stein Richard S L - - 2013
Lysine methylation is one of the important post-translational modifications (PTMs) that regulate protein functions. Up to now, proteomic identification of this PTM remains a challenge due to the lack of effective enrichment methods in mass spectrometry experiments. To address this challenge, we present here a systematic approach to predicting peptides ...
Rodríguez-Celma Jorge - - 2013
The changes in the root extract protein profile of the Prunus hybrid GF 677 rootstock (P. dulcis × P. persica) grown in hydroponics as affected by Fe deficiency and short term (24 h) Fe resupply have been studied by 2-dimensional gel electrophoresis-based techniques. A total of 335 spots were consistently ...
Lim Daphne Afn - - 2013
ABSTRACT: INTRODUCTION: Critical Care research involves an increasing level of technical and clinical interventions for the unconscious patient. If the general public has a negative (unfavourable) view of 'surrogate' consent, low recruitment rates are likely. Results bias will be introduced if study populations are small, hindering knowledge generation and transfer ...
Matushansky Igor - - 2013
Adjuvant chemotherapy for soft tissue sarcoma (STS) remains controversial while improvement in survival has never been conclusively demonstrated for metastatic STS. We identified individuals in SEER-Medicare with resected or metastatic STS, 1991-2007. Of 2,382 patients with resected STS, 106 (4.5%) received chemotherapy. High tumor grade, larger tumor size, and malignant ...
Cordelli Duccio Maria - - 2013
Mowat-Wilson syndrome (MWS) is a genetic disease caused by heterozygous mutations or deletions of the ZEB2 gene and is characterized by distinctive facial features, epilepsy, moderate to severe intellectual disability, corpus callosum abnormalities and other congenital malformations. Epilepsy is considered a main manifestation of the syndrome, with a prevalence of ...
Fongkaew Warunee - - 2013
HIV/AIDS-related stigma has been linked to poor adherence resulting in drug resistance and the failure to control HIV. This study used both quantitative and qualitative methods to examine stigma and its relationship to adherence in 30 HIV-infected Thai youth aged 14 to 21 years. Stigma was measured using the HIV ...
Stock Carmel J - - 2013
BACKGROUND: A polymorphism (rs35705950) 3 kb upstream of MUC5B, the gene encoding Mucin 5 subtype B, has been shown to be associated with familial and sporadic idiopathic pulmonary fibrosis (IPF). We set out to verify whether this variant is also a risk factor for fibrotic lung disease in other settings ...
Ma Li-Juan - - 2013
Three new monoterpene lactones, cimicifugolides A-C (1-3), along with a known one (4), were identified from the dried rhizome of Actaea cimicifuga L. that was used as traditional Chinese medicine for thousands of years with the Chinese common name of shengma. The structures of the new isolates were established using spectroscopic ...
Nissi Ritva - - 2013
ABSTRACT: BACKGROUND: Trophoblast cell (CTB) invasion into the maternal endometrium plays a crucial role during human embryo implantation and placentation. This invasion is facilitated by the activity of matrix metalloproteinases, which are regulated by tissue inhibitors of MMPs (TIMPs). METHODS: This study compares the serum levels of MMP-9, MMP-2/TIMP-2 complex, ...
Kemp E Helen - - 2013
Context:Pendrin is a transmembrane protein located at the apical end of the thyrocyte in which it mediates the efflux of iodide through the thyroid follicular cell. Recently pendrin was described as a significant antibody target in Japanese patients with Graves' disease (GD) or autoimmune hypothyroidism (AH) using an immunoblotting assay. ...
Treangen Todd J - - 2013
ABSTRACT: We describe MetAMOS, an open source and modular metagenomic assembly and analysis pipeline. MetAMOS represents an important step towards fully automated metagenomic analysis, starting with next-generation sequencing reads and producing genomic scaffolds, open-reading frames and taxonomic or functional annotations. MetAMOS can aid in reducing assembly errors, commonly encountered when ...
Luechapanichkul Rinrada R Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, - - 2013
Vaccinia VH1-related (VHR) is a dual specificity phosphatase that consists of only a single catalytic domain. Although several protein substrates have been identified for VHR, the elements that control the in vivo substrate specificity of this enzyme remain unclear. In this work, the in vitro substrate specificity of VHR was ...
Timsit Jean-François - - 2013
ABSTRACT: Catheters are most often colonized and become infected via the skin and their external surfaces in the ICU. Therefore, topical antimicrobials, including medical honey, placed at the insertion site should decrease skin colonization and catheter infections. This commentary reviews the main studies on, and the possible reasons of, topical ...
Cao Anping - - 2013
Highly sensitive detection of transcription factors is essential to the evaluation of cellular development and disease state. However, so far most detection methods are usually laborious, time-consuming with a poor sensitivity. Here, we demonstrate a simple and ultra-sensitive approach for transcription factor detection based on target-converted helicase-dependent amplification assay. We ...
Wang Jennifer R - - 2013
The SWI/SNF chromatin remodeling complex is an important regulator of gene expression that has been linked to cancer development. Expression of Brahma (BRM), a critical catalytic subunit of SWI/SNF, is lost in a variety of solid tumors. Two novel BRM promoter polymorphisms (BRM -741 and BRM -1321) have been correlated ...
Liao Rong-Zhen - - 2013
FosA is a manganese-dependent enzyme that utilizes a Mn(2+) ion to catalyze the inactivation of the fosfomycin antibiotic by glutathione (GSH) addition. We report a theoretical study on the catalytic mechanism and the factors governing the regioselectivity and chemoselectivity of FosA. Density functional theory (DFT) calculations on the uncatalyzed reaction ...
Mondal Abhishake - - 2013
A repeatable bidirectional para ⇔ dia photomagnetic effect has been observed in the cyanide-bridged Fe-Co square complex {[Fe{B(pz)(4)}(CN)(3)](2)[Co(bik)(2)](2)} . (ClO(4))(2) . 3H(2)O [where B(pz)(4) = tetrapyrazolylborate and bik = bis(1-methylimidazol-2-yl)ketone]. Magnetic measurements and low temperature single-crystal XRD experiments have shown that a complete electron transfer from the diamagnetic Fe(II)-Co(III) state ...
Siegel Bianca - - 2013
ObjectiveTo reflect on lessons learned placing endotracheal nitinol stents in children.Study DesignCase series with chart review.SettingTertiary care children's hospital.Subjects and MethodsAll children who underwent nitinol cervical tracheal stenting were included. Records were carefully reviewed for intraoperative and postoperative complications, management choices, outcomes, and factors that influenced results.ResultsBetween 1999 and 2011, ...
Koch Matthias K MK W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, - - 2013
Myxococcus xanthus, a predatory soil bacterium, has long been used as a model organism to study bacterial gliding motility. Research has revealed that two fundamentally distinct motor systems power gliding in this bacterium: repeated extensions and retractions of pili mediate social or (S-) motility, whereas the motor powering adventurous or ...
Bodenstein Marc - - 2013
ABSTRACT Varying pulmonary shunt fractions during the respiratory cycle cause oxygen oscillations during mechanical ventilation. In artificially damaged lungs, cyclical recruitment of atelectasis is responsible for varying shunt according to published evidence. We introduce a complimentary hypothesis that cyclically varying shunt in healthy lungs is caused by cyclical redistribution of ...
Lei Yu Y Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, - - 2013
The NLR (nucleotide-binding domain leucine-rich repeat containing) proteins serve as regulators of inflammatory signaling pathways. NLRX1, a mitochondria-localized NLR protein, has been previously shown to negatively regulate inflammatory cytokine production activated via the MAVS-DDX58 (RIG-I) pathway. The literature also indicates that DDX58 has a negative impact upon autophagy. Consistent with ...
Jahn Stephan C SC Department of Pharmacology and Therapeutics and the Shands Cancer Center, University of Florida, Gainesville, FL 32610, - - 2013
The cell has many mechanisms for protecting the integrity of its genome. These mechanisms are often weakened or absent in many cancers, leading to high rates of chromosomal instability in tumors. Control of the cell cycle is crucial for the function of these checkpoints, and is frequently lost in cancers ...
Yamada T - - 2013
Background and study aims: Acute colorectal obstruction (ACO) often accompanies colorectal cancer (CRC) and requires urgent treatment, but achieving elective laparoscopy-assisted colectomy (LAC) is difficult in this setting. The aim of the current study was to assess the clinical outcomes of a transanal tube (Dennis colorectal tube [DCT]) for CRC ...
Gleeson Michael - - 2013
BACKGROUND: Falls are an increasingly important and costly public health problem. Vision is key to postural stability as we age and this puts adults with visual impairments at greater risk of falls. Physical interventions improve balance in the general population and in older adults with visual impairments in residential care. ...
Azagba Sunday - - 2013
INTRODUCTION: Smoking susceptibility in early adolescence is strongly predictive of subsequent smoking behavior in youth. As such, smoking susceptibility represents a key modifiable factor in reducing the onset of smoking in young people. A growing literature has documented a number of factors that influence susceptibility to smoking; however, there is ...
Lenoir Magalie M Université de Bordeaux, Institut des Maladies Neurodégénératives, Rue Léo-Saignat, Bordeaux, - - 2013
Epidemiological research shows that the proportion of drug users who become addicted to heroin is higher than to cocaine. Here we tested whether this difference could be due to a difference in the addiction liability between the two drugs. Addiction liability was assessed under a discrete-trials choice procedure by measuring ...
Huang Hao - - 2013
Multiple antibiotic resistance regulator (MarR) family transcriptional regulators usually regulate gene activity by responding to specific ligands. Here we show that TamR (trans-aconitate methyltransferase regulator), a MarR homolog from Streptomyces coelicolor, functions in oxidative stress responses to regulate a key step in central metabolism. The gene encoding TamR is oriented ...
Cammaerts Marie-Claire - - 2013
We used the ant species Myrmica sabuleti as a model to study the impact of electromagnetic waves on social insects' response to their pheromones and their food collection. We quantified M. sabuleti workers' response to their trail, area marking and alarm pheromone under normal conditions. Then, we quantified the same ...
Chaiyachati Barbara H BH Department of Immunobiology, Yale University Medical School, New Haven, CT 06520, - - 2013
Treg activation in response to environmental cues is necessary for regulatory T cells (Tregs) to suppress inflammation, but little is known about the transcription mechanisms controlling Treg activation. We report that despite the known proinflammatory role of the chromatin-remodelling factor BRG1 in CD4 cells, deleting Brg1 in all αβ T ...
Stoletov Konstantin K Department of Pathology, University of California, San Diego, La Jolla, CA 92093, - - 2013
Breast cancer and melanoma cells commonly metastasize to the brain using homing mechanisms that are poorly understood. Cancer patients with brain metastases display poor prognosis and survival due to the lack of effective therapeutics and treatment strategies. Recent work using intravital microscopy and preclinical animal models indicates that metastatic cells ...
Cuny Thomas - - 2013
CONTEXT: germline mutations in the AIP gene have been identified in young patients (age ≤ 30 years old) with sporadic pituitary macroadenomas. Otherwise, there are few data concerning the prevalence of MEN1 mutations in such population. OBJECTIVE: We assessed the prevalence of both AIP and MEN1 genetic abnormalities (mutations and ...
Yang Mingyu - - 2013
Palladium-catalyzed direct lactonization of 2-arylacetic acids through a reaction sequence that includes C-H activation/C-O formation is reported. This method provides a concise and efficient pathway to synthesize fully functionalized benzofuranone derivatives, which are highly relevant to bioactive natural and synthetic products.
Sun Defang D State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, 22 Hankou Road, Nanjing 210093, PR - - 2013
MicroRNAs (miRNAs) are known to play a vital role in colorectal cancer. We found a widespread disruption in miRNA expression during colorectal tumorigenesis using microarray and quantitative RT-PCR analysis; of the 161 miRNAs altered in colorectal cancer compared with normal adjacent tissue samples, miR-31 was the most significantly dysregulated. We ...
Wang Shuai - - 2013
Antigen receptor engagement triggers lymphocyte activation and proliferation by activating several transcription factors including NF-κB. Caspase recruitment domain (CARD)-containing membrane-associated guanylate kinase (MAGUK) protein1 (CARMA1) is an essential adaptor protein that links antigen receptors to NF-κB activation. Here, we identify stress-induced-phosphoprotein 1 homology and U-box containing protein 1 (STUB1) as ...
Radosa Mp - - 2013
OBJECTIVE: To evaluate laparoscopic lymphocele fenestration (LLF) as a first-line treatment in gynaecological cancer patients with a history of retroperitoneal lymph node dissection (LND). DESIGN: Retrospective cohort study. SETTING: A tertiary referral centre. POPULATION: Patients who underwent LLF between January 2001 and December 2010 for a symptomatic lymphocele following retroperitoneal ...
Jones Roanne R - - 2013
The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C16-KTTKS is investigated, and related to its self-assembly into nanotapes structures. This PA is used in anti-wrinkle cosmeceutical applications (tradename MatrixylTM). We prove that C16-KTTKS stimulates collagen production in a concentration-dependent manner ...
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