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Results 551 - 600 of 2388
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Fuller Christina H - - 2013
Exposure to high levels of traffic-generated particles may pose risks to human health; however, limited measurement has been conducted at homes near highways. The purpose of this study was to characterize differences between indoor and outdoor particle number concentration (PNC) in homes near to and distant from a highway and ...
Aneni Ehimen C - - 2013
Sickle cell disease (SCD) is a chronic debilitating disorder affecting erythrocytes, which is especially prevalent throughout Sub-Saharan Africa and among individuals of African descent. Because malaria is thought to be a significant cause of morbidity and mortality in patients with SCD, malaria chemoprophylaxis is often recommended for these patients. In ...
de Mattos Andresa Marques - - 2013
Peritoneal dialysis (PD) frequently leads to body weight gain, which appears to be a potential cause of the chronic inflammation frequently present in these patients. The consequences of this inflammation are impaired nutritional status, accelerated atherosclerosis, and increased mortality. To assess the association between inflammation and body fat in female ...
Wang Hui - - 2013
Silk scaffolds having biomimetic hierarchical porous structures were achieved by carefully tuning liquid-liquid separation in regenerated silk fibroin solutions. Such scaffolds show greatly enhanced cellular responses.
Cooper Richard - - 2013
The sale of over-the-counter (OTC) medicines from community pharmacies offers important opportunities for members of the public to access medicines and self-treat conditions. They are increasingly recognised, however, as having the potential for abuse and harm despite their perceived relative safety. This study reports on a qualitative study that explored ...
Broer Linda L 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands [2] Netherlands Consortium for Healthy Aging, Leiden University Medical Center, Leiden, The - - 2013
Telomere length (TL) has been associated with aging and mortality, but individual differences are also influenced by genetic factors, with previous studies reporting heritability estimates ranging from 34 to 82%. Here we investigate the heritability, mode of inheritance and the influence of parental age at birth on TL in six ...
Goldsmith Lesley - - 2013
Since the 1990s, there has been a rapid expansion in the number and type of genetic tests available via health professionals; the last 10 years, however, have seen certain types of genetic and genomic tests available direct-to-consumer. The aim of this systematic review was to explore the topic of direct-to-consumer genetic ...
Sahin Ismail - - 2013
There is little consensus regarding the indications, ideal incision, or reconstruction method for prophylactic mastectomy. In addition, the biggest limitation in studies that assess either patient satisfaction or operation results is the lack of group homogeneity. In our center, 21 bilateral prophylactic mastectomies, due to breasts at high risk for ...
Grünwald Stefanie - - 2013
Diet is generally believed to affect the aging process. The effects of complex foods on life span can be investigated using simple models that produce rapid results and allow the identification of food-gene interactions. Here, we show that 1 % lyophilized broccoli, added to flour as a dietary source, significantly increases ...
Dickson David J - - 2013
Cyanobacteria inhabit nearly every ecosystem on earth, play a vital role in nutrient cycling, and are useful as model organisms for fundamental research in photosynthesis and carbon and nitrogen fixation. In addition, they are important for several established biotechnologies for producing food additives, nutritional and pharmaceutical compounds, and pigments, as ...
Freire João Miguel - - 2013
One of the major challenges in the drug development process is biodistribution across epithelia and intracellular drug targeting. Cellular membrane heterogeneity is one of the major drawbacks in developing efficient and sustainable drug delivery systems, which brings the need to study their interaction with lipids in order to unravel their ...
Del Prete Sonia - - 2013
Abstract Vibrio cholerae, a Gram-negative bacterium, is the causative agent of cholera and colonizes the upper small intestine where sodium bicarbonate is present at a high concentration. Sodium bicarbonate is a potential inducer of virulence gene expression. Bacteria can increase cytosolic bicarbonate levels through the existence of transporter family proteins ...
King J J Division of Plant and Crop Sciences, School of Biosciences, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK. - - 2013
In many cultivated crop species there is limited genetic variation available for the development of new higher yielding varieties adapted to climate change and sustainable farming practises. The distant relatives of crop species provide a vast and largely untapped reservoir of genetic variation for a wide range of agronomically important ...
Zhang Fujin - - 2013
The spatial variability and temporal trend in concentrations of the organochlorine pesticides (OCPs), hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethane (DDT), in soils and agricultural corps were investigated on an intensive horticulture area in Hohhot, North-West China, from 2008 to 2011. The most frequently found and abundant pesticides were the metabolites of DDT ...
Schipper Robert-Jan - - 2013
To analyse bilateral differences in the cross-sectional area of the internal mammary artery (IMA) and vein (IMV) in breast cancer patients compared to healthy controls. On 135 breast MRIs the cross-sectional areas of the IMA and IMV were measured on the left and right side in the second and third ...
Lum Siew Kheong - - 2013
The Association of Southeast Asian Nations (ASEAN) Mutual Recognition Arrangement (MRA) on medical practitioners' agreement will become a reality in the year 2015. Doctors registered in one ASEAN country will be given reciprocal recognition in another country under this agreement. Rapid and excessive movement of human resources between countries in ...
Thanakwang Kattika - - 2013
This study aimed to clarify the concept of productive engagement as it applies to older adults. The concept analysis was based on Walker and Avant's eight-step method. A literature review of articles published in English between 1990 and 2011 (n = 37) was conducted, using an electronic search of multiple sources. Results ...
Schrooten M G S - - 2013
BACKGROUND: A prominent behavioural consequence of pain is the temporary suspension of current activities with intent to resume them later. Little is known about the effects of such pain-contingent task interruptions. This experiment examines the influence of pain-contingent interruptions on the amount of time spent performing a cognitive achievement task: ...
Wang K Y - - 2013
Selenium is essential for the normal life processes, and all animals, including fish, need this inorganic element. In order to research the pathology of selenium deficiency in common carp, Cyprinus carpio L., 360 juvenile carp were allocated to three treatments. Each treatment containing 120 fish was randomly divided into four ...
Hama Suleiman Sozan - - 2013
Abstract Aims. The aim was to compare the fracture strength of porcelain fused to metal crowns with copings fabricated in Co-Cr using different manufacturing techniques (casting, milling and laser-sintering) with crowns manufactured in a high-gold alloy. Methods. A total of 50 identical crowns were fabricated and sub-divided into five groups; ...
Cai Junchao - - 2013
Tumor metastasis involves a series of biological steps during which the tumor cells acquire the ability to invade surrounding tissues and survive outside the original tumor site. During the early stages, the cancer cells undergo an epithelial-mesenchymal transition (EMT). Wnt/β-catenin signaling is known to drive EMT and metastasis. Here we ...
Ardekani Babak A - - 2013
The corpus callosum (CC) is the largest fiber bundle connecting the left and right cerebral hemispheres. It has been a region examined extensively for indications of various pathologies, including Alzheimer's disease (AD). Almost all previous studies of the CC in AD have been concerned with its size, particularly its mid-sagittal ...
Soriano Alessandra - - 2013
Familial Mediterranean fever (FMF) is a recessive, autosomal, auto-inflammatory disorder characterised by brief, recurring, self-limited episodes of fever and serositis resulting in abdominal, chest, joint and muscular pain; it is the most common of the periodic hereditary fevers and mostly affects Mediterranean populations. Daily administration of colchicine, a tricyclic alkaloid ...
Sayakhot P - - 2013
Abstract Objective: Investigation of clinicians' understanding of early menopause (EM) diagnosis/management in women with breast cancer (BC). Methods: A cross-sectional study of 176 randomly recruited Australian clinicians (35 gynaecologists, 35 endocrinologists, 36 oncologists, 35 breast surgeons and 35 general practitioners (GPs)) involved in the care of women with BC. This ...
Yackerson Naomy S - - 2013
The main objective of this study was to evaluate the role of the concentration of solid air-suspended particles (SSP) in the incidence of mental disorders. The study is based on 1,871 cases, registered in the Beer-Sheva Mental Health Center (BS-MHC) at Ben-Gurion University (Israel) during a 16-month period from 2001 ...
Liu Baojian - - 2013
Flowing supercritical CO(2) was used to activate a cross section of microporous coordination polymers (MCPs) directly from DMF, thus avoiding exchange with a volatile solvent. Most MCPs displayed exceptional surface areas directly after treatment although those with coordinatively unsaturated metals benefit from heating. The method presents an advance in efficiency ...
Mulvey Claire - - 2013
Depletion of DNA replication initiation factors such as CDC7 kinase triggers the origin activation checkpoint in healthy cells and leads to a protective cell cycle arrest at the G1 phase of the mitotic cell division cycle. This protective mechanism is thought to be defective in cancer cells. To investigate how ...
Pearce E N - - 2013
Iodine is required for the production of thyroid hormone. Thyroid hormone affects many metabolic processes in the body, including maturation of the central nervous system. In early pregnancy, the fetus is dependent on maternal thyroid hormone for normal brain development. If iodine deficiency leads to inadequate production of thyroid hormone ...
Willemink Martin J - - 2013
OBJECTIVES: To present the results of a systematic literature search aimed at determining to what extent the radiation dose can be reduced with iterative reconstruction (IR) for cardiopulmonary and body imaging with computed tomography (CT) in the clinical setting and what the effects on image quality are with IR versus ...
Cervera-Procas Ramón - - 2013
A polymer network is prepared by the thiol-yne photopolymerization of multifunctional dendrimer with a tetrathiol crosslinker. The network obtained shows a liquid crystalline phase at room temperature, which has been characterized by optical microscopy, differential scanning calorimetry, and X-ray diffraction. Photoinduced deformation of uniaxially aligned free-standing films of the photocrosslinked ...
Iwasaki Yasushi - - 2013
A Japanese male patient presented with gait disturbance at the age of 69 years. His principal symptom was cerebellar ataxia for several years. He was initially diagnosed as having olivopontocerebellar atrophy because dysarthria and ataxia gradually developed, and head CT scan showed apparent atrophy of the cerebellum and brainstem and ...
Li Yong - - 2013
Background/Aims: The purpose of comprehensive treatment for early gastric cancer (EGC) is curing tumor, prevention of recurrence or metastasis. The aim of the present study was to analyze the clinical pathological characteristics of EGC, and to find out factors which influence lymph node metastasis. Methodology: Records of 417 patients with ...
Cipolla Marilyn J MJ Departments of Neurological Sciences, Obstetrics, Gynecology and Reproductive Sciences, Pharmacology, University of Vermont College of Medicine, Burlington, VT, USA. - - 2013
The adaptation of the cerebral circulation to pregnancy is unique from other vascular beds. Most notably, the growth and vasodilatory response to high levels of circulating growth factors and cytokines that promote substantial hemodynamic changes in other vascular beds is limited in the cerebral circulation. This is accomplished through several ...
Pols Maaike S - - 2013
Targeted delivery of lysosome-associated membrane proteins is important for lysosome stability and function. Here we identify a pathway for transport of lysosome-associated membrane proteins directly from the trans-Golgi network to late endosomes, which exists in parallel to mannose 6-phosphate receptor and clathrin-dependent transport of lysosomal enzymes to early endosomes. By ...
Verma Chandan - - 2013
ABSTRACT: BACKGROUND: Host defences play a key role in tumour growth. Some of the benefits of chemotherapy may occur through modulation of these defences. The aim of this study was to define the status of regulatory cells in women with large and locally advanced breast cancers (LLABCs) undergoing neoadjuvant chemotherapy ...
Sabbatini Massimo - - 2013
Sigma factor σ(54) has a distinct modus operandi for mediating the activation of bacterial RNA polymerase (RNAP) at promoter recognition motifs 12 and 24 base pairs upstream from transcription start sites. σ(54) was thought to act as monomer in all transcription steps. We provide evidence that σ(54) of Pseudomonas putida ...
Talarczyk Matthew R - - 2013
Reconstruction of large external hemipelvectomy oncologic defects of the proximal limb and trunk remains a formidable surgical challenge. Large pelvic defects can result in exposed bones, neurovascular structures, and surgical hardware due to a paucity of soft tissue coverage. When the size of a hemipelvectomy defect precludes coverage by local ...
Malik Aeesha Nj - - 2013
Health services globally and in the UK face challenges from increasing need and rising expectations to inequalities and financial constraints. The UK government has recently published a Public Health Framework for the first time. This has included preventable sight loss as an outcome measure for the nation's public health reflecting ...
Pardo-Crespo Maria R MR Division of Community Paediatric and Adolescent Medicine, Department of Paediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, - - 2013
Socioeconomic status (SES) is an important determinant of health, but SES measures are frequently unavailable in commonly used datasets. Area-level SES measures are used as proxy measures of individual SES when the individual measures are lacking. Little is known about the agreement between individual-level versus area-level SES measures in mixed ...
Patel Bhavini - - 2013
Cerebral microbleeds (CMBs) are common in cerebral small vessel disease. They may cause cognitive impairment, possibly via white matter tract disruption but previous studies have produced inconsistent results. We determined whether CMB number and location are associated with impaired cognition in symptomatic small vessel disease and whether any association was ...
Kumar Vinod - - 2013
No fluorescence emission of the naphtholate anion is observed from ionic liquids with an imidazolium cation containing a C2 hydrogen (C2H). This is attributed to the formation of a "dark" complex between the imidazolium cation and the excited naphtholate anion.
Fitzcharles Mary-Ann - - 2013
Workplace injuries may be implicated in the causation of fibromyalgia (FM), hence linking FM to compensation. We examined the appeals by workers directed to an appeals tribunal for causation of FM following soft-tissue injury sustained in the workplace. One hundred fifty tribunal decisions relevant to FM were examined using a ...
Duivenvoorden W C WC Division of Urology, Department of Surgery, McMaster University, Hamilton, Ontario, - - 2013
Evidence suggests that dysregulation of energy-sensing pathways closely associates with renal cell carcinoma (RCC) development. The metabolic regulation is largely controlled by 5'-AMP activated protein kinase (AMPK) which is activated through phosphorylation by LKB1. The expression of LKB1 was determined by reverse transcription-PCR using 10 clinical clear cell RCC (ccRCC) ...
Soong Christine - - 2013
BACKGROUND: Emergency department (ED) overcrowding is a threat to patient safety and public health. Availability of specialty consultation to the ED may contribute to overcrowding. We implemented a novel intervention using education, goal setting and real-time performance feedback to improve time to admission for patients referred to general internal medicine ...
Nizioł Joanna - - 2013
Preparation is described of the surface of the first monoisotopic cationic (109)Ag nanoparticles (AgNPs), covering commercial and modified MALDI targets, along with examples of the use in MS analyses of various low-molecular-weight (LMW) organic compounds, including alkaloids, saccharides, amino acids, nucleosides, nucleic bases, and other organics. The new targets, compared ...
Hobkirk James P - - 2013
AIMS: The objective of this study was to establish the acute effects of hypoxia on clinical, spirometric, haemodynamic, and echocardiographic variables. Reducing inspired oxygen to 15%, as experienced during commercial air travel, decreases arterial oxygen saturation, increases respiratory rate and pulmonary artery pressure in healthy subjects. The effect on patients ...
Jing Yao - - 2013
An amphiphilic hyaluronic acid (HA)-g-all-trans retinoid acid (HRA) conjugate was successfully developed as a tumor targeting nanocarrier for potentially synergistic combination chemotherapy of all-trans retinoid acid (ATRA) and paclitaxel (PTX). The HRA conjugate was synthesized by an imine reaction between HA-COOH and ATRA-NH2. PTX-loaded HRA nanoparticles possessed a high loading ...
Pakkasjärvi Niklas - - 2013
Upper-limb defects with deficiencies of the radial ray have varying etiologies, with a low proportion of true Mendelian disorders. We carried out a population-based study to elucidate the birth prevalence and clinical spectrum of radial ray deficiencies in Finland. We identified all births with radial ray deficiency reported to the ...
Mansourian M - - 2013
Nowadays, due to the wide use of mobile phones, extensive studies have been carried out on the effects of magnetic field (MF) on public health. In this paper, we study the effect of 217 Hz MF similar to that generated by GSM900 mobile phones on cancer and healthy cells treated with ...
Zhang Jing - - 2013
BACKGROUND: Patients with lung cancer are at high risk of venous thromboembolism (VTE), and VTE predicts a poor prognosis. Anticoagulation therefore might be beneficial for these patients. It is not clear whether anticoagulants could improve survival and other outcomes in patients with lung cancer with no indication for anticoagulation. METHODS: ...
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