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Foulk Michael S MS Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02912, - - 2013
Regulation of DNA replication is critical, and loss of control can lead to DNA amplification. Naturally occurring, developmentally regulated DNA amplification occurs in the DNA puffs of the late larval salivary gland giant polytene chromosomes in the fungus fly, Sciara coprophila. The steroid hormone ecdysone induces DNA amplification in Sciara, ...
Richardson Kelly K KK Comprehensive Access & Delivery Research and Evaluation Center, Iowa City VA Healthcare System, Mailstop 152, 601 Highway West, Iowa City, IA 52246, - - 2013
Hip fracture is a medical emergency for which delayed treatment increases risk of disability and death. In emergencies, veterans without access to a Veterans Administration (VA) hospital may be admitted to non-VA hospitals under fee-based (NVA-FB) care paid by the VA. The affect of NVA-FB care for treatment and outcomes ...
Pruett Brandon S BS Department of Pharmacology, Louisiana State University Health Sciences Center, School of Medicine, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130, - - 2013
Delivery of exogenous glial cell line-derived neurotrophic factor (GDNF) increases locomotor activity in rodent models of aging and Parkinson's disease in conjunction with increased dopamine (DA) tissue content in substantia nigra (SN). Striatal GDNF infusion also increases expression of GDNF's cognate receptor, GFRα1, and tyrosine hydroxylase (TH) ser31 phosphorylation in ...
Pegueroles C C Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain. - - 2013
Gene flow (defined as allele exchange between populations) and gene flux (defined as allele exchange during meiosis in heterokaryotypic females) are important factors decreasing genetic differentiation between populations and inversions. Many chromosomal inversions are under strong selection and their role in recombination reduction enhances the maintenance of their genetic distinctness. ...
de Cara M Á R MÁ Departamento de Mejora Genética Animal, INIA, Madrid, Spain. - - 2013
Conservation programmes aim at minimising the loss of genetic diversity, which allows populations to adapt to potential environmental changes. This can be achieved by calculating how many offspring every individual should contribute to the next generation to minimise global coancestry. However, an undesired consequence of this strategy is that it ...
Morgan Jonathan J JJ Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC, - - 2013
This study represents the first longitudinal, within-subject (1) H MRS investigation of the developing rat brain spanning infancy, adolescence and early adulthood. We obtained neurometabolite profiles from a voxel located in a central location of the forebrain, centered on the striatum, with smaller contributions for the cortex, thalamus and hypothalamus, ...
Kurzius-Spencer Margaret M Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, - - 2013
Chronic exposure to arsenic (As) in food and water is a significant public health problem. Person-specific aggregate exposure is difficult to collect and modeling based on limited food As residue databases is of uncertain reliability. Two cross-sectional population exposure studies, the National Human Exposure Assessment Survey-Arizona and Arizona Border Survey, ...
Groetz Simon F SF Department of Radiology, University Hospital Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn, Germany. - - 2013
To evaluate safety of coblation of simulated lytic metastases in human cadaveric vertebral bodies by measuring heat distribution during thermal tissue ablation and comparing it to radiofrequency ablation (RFA). Three devices were compared: a 10 mm single-needle RFA electrode, a 20 mm array RFA electrode and the coblation device. To ...
Armstrong Katrina K Division of General Internal Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA. - - 2013
After five decades of growth that has included advances in medical education and health care delivery, value cohesion, and integration of diversity, we propose an overarching mission for academic general internal medicine to lead excellence, change, and innovation in clinical care, education, and research. General internal medicine aims to achieve ...
Gong Jicheng J Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, - - 2013
Underlying mechanisms by which air pollutants adversely affect human health remain poorly understood. Oxidative stress has been considered as a potential mechanism that may promote lipid peroxidation by reactive oxygen species, leading to the formation of malondialdehyde (MDA) that is excreted in biofluids (e.g., urine and exhaled breath condensate (EBC)). ...
Shannahan Jonathan H JH Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, - - 2013
In biological environments, nanomaterials associate with proteins forming a protein corona (PC). The PC may alter the nanomaterial's pharmacokinetics and pharmacodynamics, thereby influencing toxicity. Using a label-free mass spectrometry-based proteomics approach, the composition of the PC is examined for a set of nanotubes (NTs) including unmodified and carboxylated single- (SWCNT) ...
Bertrand Todd T Department of Orthopaedics, Duke University Medical Center, Durham, NC 27710, - - 2013
Avascular necrosis (AVN) of the femoral head is a potential complication in patients with slipped capital femoral epiphysis (SCFE), radiographically occurring in 3-60%. This may lead to early hip fusion or hip arthroplasty. Free vascularized fibular grafting (FVFG) may provide a reasonable means to preserve the femoral head. We asked: ...
Narasimhan Arunn A Heat Transfer and Thermal Power Laboratory, Indian Institute of Technology Madras, Chennai-600036, India. - - 2013
During retinal surgical treatment often the gel-like vitreous humor is replaced by aqueous substitutes. A two-dimensional computational model is developed for simulating transpupillary thermotherapy (TTT) process in a human eye under post-retinal treatment. The model accounts for natural convection in vitreous humor and the choroidal blood perfusion. Time dependent and ...
Burandt E E Department of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany. - - 2013
AIB1 (amplified in breast cancer 1) is an estrogen receptorα (ERα) co-activator, known to be amplified and overexpressed in a fraction of breast cancers. It has been linked to prognosis and tamoxifen resistance. However, results have been ambiguous. The different functions of AIB1 in ERα-positive and -negative disease are poorly ...
Moya Pablo R PR Laboratory of Clinical Science, NIMH-Intramural Research Program, Bethesda, MD 20819, USA. - - 2013
The recent finding that the neuronal cadherin gene CDH2 confers a highly significant risk for canine compulsive disorder led us to investigate whether missense variants within the human ortholog CDH2 are associated with altered susceptibility to obsessive-compulsive disorder (OCD), Tourette disorder (TD) and related disorders. Exon resequencing of CDH2 in ...
Crane Alice L AL Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, New York, - - 2013
Chlorpyrifos (CPF) is applied seasonally in Egypt by adolescent agricultural workers and the extent of occupational exposure and the potential for environmental CPF exposure in this population is poorly understood. Adolescent pesticide applicators (n=57; 12-21 years of age) and age-matched non-applicators (n=38) from the same villages were followed for 10 ...
Mao Jun J JJ Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. - - 2013
While patients often use the internet as a medium to search for and exchange health-related information, little is known about the extent to which patients use social media to discuss side effects related to medications. We aim to understand the frequency and content of side effects and associated adherence behaviors ...
Ip E H EH Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA. - - 2013
Motivated by an application to childhood obesity data in a clinical trial, this paper describes a multi-profile hidden Markov model (HMM) that uses several temporal chains of measures respectively related to psychosocial attributes, dietary intake, and energy expenditure behaviors of adolescents in a school setting. Using these psychological and behavioral ...
Ladouceur Martin M Research Center of Montreal Heart Institute, Montreal, Quebec, Canada. - - 2013
The optimal study design for identifying rare variants associated with common disease is not yet clear and researchers have to decide whether to prioritize lower sequencing coverage on larger sample sizes, or higher coverage on smaller sample sizes. High-coverage sequencing affords several advantages, such as genotype accuracy and improved identification ...
Ruderfer Douglas M DM Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, - - 2013
Recent reports suggest that somatic structural changes occur in the human genome, but how these genomic alterations might contribute to disease is unknown. Using samples collected as part of the International Schizophrenia Consortium (schizophrenia, n=3518; control, n=4238) recruited across multiple university research centers, we assessed single-nucleotide polymorphism genotyping arrays for ...
Schlotawa Lars L Department of Pediatrics and Pediatric Neurology, Georg August University Göttingen, Göttingen, - - 2013
Multiple sulfatase deficiency (MSD) is a rare inborn error of metabolism affecting posttranslational activation of sulfatases by the formylglycine generating enzyme (FGE). Due to mutations in the encoding SUMF1 gene, FGE's catalytic capacity is impaired resulting in reduced cellular sulfatase activities. Both, FGE protein stability and residual activity determine disease ...
Sommariva Elena E Genomic Unit for the Diagnosis of Human Pathologies, Center for Translational Genomics and Bioinformatics, San Raffaele Scientific Institute, Milano, - - 2013
Brugada syndrome is an inherited arrhythmogenic disorder leading to sudden death predominantly in the 3-4 decade. To date the only reliable treatment is the implantation of a cardioverter defibrillator; however, better criteria for risk stratification are needed, especially for asymptomatic subjects. Brugada syndrome genetic bases have been only partially understood, ...
Wu Jianhua J Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, - - 2013
There is uncertainty over the population prevalence of people with Down's syndrome in England and Wales. This study aimed to estimate the population prevalence of Down's syndrome in England and Wales in 2011. A meta-analysis of published survival rates of people with Down's syndrome from 1938 to 2010 was conducted ...
Croonen Ellen A EA Department of Paediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, The - - 2013
In recent studies on prenatal testing for Noonan syndrome (NS) in fetuses with an increased nuchal translucency (NT) and a normal karyotype, mutations have been reported in 9-16% of cases. In this study, DNA of 75 fetuses with a normal karyotype and abnormal ultrasound findings was tested in a diagnostic ...
Shkeir Omar O Departments of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, - - 2013
Head and neck squamous cell carcinomas (HNSCCs) have devastating morbidity rates with mortality mainly because of metastasis. Multiplex enzyme-linked immunosorbent assay (ELISA) to assay a variety of cytokine levels secreted by a panel of stage-specific and anatomic site-specific primary, and recurrent and metastatic University of Michigan-HNSCC cell lines over a ...
Reignier Jean J Medical-Surgical Intensive Care Unit, District Hospital Center, La Roche-sur-Yon, France. - - 2013
Monitoring of residual gastric volume is recommended to prevent ventilator-associated pneumonia (VAP) in patients receiving early enteral nutrition. However, studies have challenged the reliability and effectiveness of this measure. To test the hypothesis that the risk of VAP is not increased when residual gastric volume is not monitored compared with ...
Hasegawa Kohei K Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, 326 Cambridge St, Ste 410, Boston, MA 02114, USA. - - 2013
It is unclear whether advanced airway management such as endotracheal intubation or use of supraglottic airway devices in the prehospital setting improves outcomes following out-of-hospital cardiac arrest (OHCA) compared with conventional bag-valve-mask ventilation. To test the hypothesis that prehospital advanced airway management is associated with favorable outcome after adult OHCA. ...
Reid Rachel O RO Centers for Medicare & Medicaid Services, Center for Medicare & Medicaid Innovation, Rapid-Cycle Evaluation Group, Baltimore, MD 21244, - - 2013
The US Centers for Medicare & Medicaid Services publishes star ratings reflecting Medicare Advantage plan quality to inform enrollment decisions. To assess the association between publicly reported Medicare Advantage plan quality ratings and enrollment. Cross-sectional study of 2011 Medicare Advantage enrollments among 952,352 first-time enrollees and 322,699 enrollees switching plans. ...
Chertow Daniel S DS Critical Care Medicine Department, Clinical Center, National Institutes of Health, 10 Center Dr, Room 2C145, Bethesda, MD 20892-1662, USA. - - 2013
Bacterial coinfection complicated nearly all influenza deaths in the 1918 influenza pandemic and up to 34% of 2009 pandemic influenza A(H1N1) infections managed in intensive care units worldwide. More than 65,000 deaths attributable to influenza and pneumonia occur annually in the United States. Data from 683 critically ill patients with ...
Schlösser Magnus - - 2013
Highly accurate, in-line and real-time composition measurements of gases are mandatory in many processing applications. The quantitative analysis of mixtures of hydrogen isotopologues ($\rm{H_2}$, $\rm{D_2}$, $\rm{T_2}$, $\rm{HD}$, $\rm{HT}$ and $\rm{DT}$) is of high importance in such fields as DT fusion, neutrino mass measurements using tritium $\beta$-decay or photonuclear experiments where ...
Kauppinen Ari - - 2013
Until recently, the freeze-drying process and formulation development have suffered from a lack of micro-scale analytical tools. Using such an analytical should decrease the required sample volume and also shorten the duration of the experiment compared to a laboratory scale setup. This study evaluated the applicability of Raman spectroscopy for ...
Hlubocky Fay J - - 2013
ABSTRACT Despite the recent advances in cancer therapeutics for Lymphoma (Lym), a continuum of disease, treatment, and psychological challenges remain for the clinical management of the Lym patient adversely impacting health-related quality of life. In response, this study presents the development and validation of the NCCN-FACT Lymphoma Symptom Index-18 (FLymSI-18). ...
Alvarado Anthony S - - 2013
We report 3 cases of Clostridium difficile-associated hemolytic uremic syndrome (HUS) with biopsy proven renal thrombotic microangiopathy. Two patients with acute renal failure were kidney transplants recipients whereas the third patient developed renal failure in the native kidneys. The presentation was preceded by acute diarrhea and stool. Clostridium difficile toxin ...
Lee Li-Hui - - 2013
Personal Health Record systems (PHRs) provide opportunities for patients to access their own PHR. However, PHRs are teeming with medical terminologies, such as disease and symptom names, etc. Patients need readily understandable and useful health knowledge in addition to their records in order to enhance their self-care ability. This study ...
Szmigielski Stanislaw - - 2013
For years, radiofrequency (RF) and microwave (MW) radiations have been applied in the modern world. The rapidly increasing use of cellular phones called recent attention to the possible health risks of RF/MW exposures. In 2011, a group of international experts organized by IARC (International Agency for Research on Cancer in ...
Tvarijonaviciute A - - 2013
The objective of this study was to evaluate and compare different sample treatments and storage conditions in order to determine optimal conditions for total and acylated canine ghrelin measurement using ELISA assays. Under the conditions assessed in this study, total ghrelin concentration was stable when stored at room temperature or ...
Liu Chun-Ming - - 2013
In recent years, peptide hormones have been recognized as important signal molecules in plants. Genetic characterization of such peptides is challenging since they are usually encoded by small genes. As a proof of concept, we used the well-characterized stem cell-restricting CLV3 to develop an antagonistic peptide technology by transformations of ...
Kikuchi Azusa - - 2013
The excited states of UV-B absorber, 4-methylbenzylidenecamphor (MBC) have been studied through measurements of UV absorption, phosphorescence, triplet-triplet (T-T) absorption, and steady-state and time-resolved electron paramagnetic resonance spectra in ethanol. The energy level and lifetime of the lowest excited triplet (T1) state of MBC were determined. The energy level of ...
James Matthew T - - 2013
BACKGROUND: CONTRAST-INDUCED ACUTE KIDNEY INJURY (CI-AKI) HAS BEEN ASSOCIATED WITH MORTALITY, ALTHOUGH IT HAS BEEN SUGGESTED THIS ASSOCIATION MAY BE ATTRIBUTABLE TO CONFOUNDING. WE PERFORMED A SYSTEMATIC REVIEW AND META-ANALYSIS TO CHARACTERIZE THE ASSOCIATIONS BETWEEN CI-AKI AND SUBSEQUENT CLINICAL OUTCOMES.METHODS AND RESULTS: WE IDENTIFIED STUDIES USING MEDLINE (1950 TO JUNE ...
Wang Youbin - - 2013
Objective :  Minor cleft lip deformities are also called lesser-form cleft lips. A furrowed philtral column is one of the important characters of these deformities. Many surgical methods have been adopted to correct it with less than satisfactory results. In this article, a dermis reconstructive method was introduced. Patients :  ...
Sivanandan Sindhu - - 2013
Objective To compare the incidence of medical closure of patent ductus arteriosus (PDA) and adverse events (acute renal dysfunction, necrotizing enterocolitis, spontaneous intestinal perforation, and gastrointestinal bleeding) between preterm infants who received indomethacin and ibuprofen for the treatment of PDA.Study Design A retrospective comparative effectiveness evaluation study was conducted on preterm infants ...
Romero Isabella S - - 2013
To produce conductive, biocompatible, and mechanically robust materials for use in bioelectrical applications, we have developed a new strategy to selectively incorporate poly(pyrrole) (Ppy) into constructs made from silk fibroin. Here, we demonstrate that covalent attachment of negatively charged, hydrophilic sulfonic acid groups to the silk protein can selectively promote ...
Gagnon Kevin J - - 2013
The structural change and resilience of a single crystal of a metal-organic framework (MOF), Zn(HO3PC4H8PO3H) •2H2O (ZAG-4), was investigated under high pressures (0 - 9.9 GPa) using in situ single crystal X-ray diffraction. Although the unit cell volume decreases over 27%, the quality of the single crystal is retained and ...
Chisada Shin-Ichi - - 2013
Vibrios, distributed in marine and brackish environments, can cause vibriosis in fish and shellfish under appropriate conditions. Previously, we clarified by thin-layer chromatography (TLC) overlay assay that (35) S-labeled Vibrio trachuri adhered to GM4 isolated from red sea bream intestine (Chisada et al. Biochem. Biophys. Res. Commun. 333, 367-373, 2005). ...
Han Na-Young - - 2013
OBJECTIVE: Inflammatory bowel disease (IBD) is a disease showing relapsing and remitting inflammatory courses of the colon and small intestine, mostly Crohn's disease (CD) and ulcerative colitis (UC). Biomarkers discriminating UC and CD, especially in cases with indeterminate type, and reflecting disease activities are still lacking, but advanced technology of ...
Yamada T - - 2013
Background and study aims: Acute colorectal obstruction (ACO) often accompanies colorectal cancer (CRC) and requires urgent treatment, but achieving elective laparoscopy-assisted colectomy (LAC) is difficult in this setting. The aim of the current study was to assess the clinical outcomes of a transanal tube (Dennis colorectal tube [DCT]) for CRC ...
Gleeson Michael - - 2013
BACKGROUND: Falls are an increasingly important and costly public health problem. Vision is key to postural stability as we age and this puts adults with visual impairments at greater risk of falls. Physical interventions improve balance in the general population and in older adults with visual impairments in residential care. ...
Azagba Sunday - - 2013
INTRODUCTION: Smoking susceptibility in early adolescence is strongly predictive of subsequent smoking behavior in youth. As such, smoking susceptibility represents a key modifiable factor in reducing the onset of smoking in young people. A growing literature has documented a number of factors that influence susceptibility to smoking; however, there is ...
Huang Hao - - 2013
Multiple antibiotic resistance regulator (MarR) family transcriptional regulators usually regulate gene activity by responding to specific ligands. Here we show that TamR (trans-aconitate methyltransferase regulator), a MarR homolog from Streptomyces coelicolor, functions in oxidative stress responses to regulate a key step in central metabolism. The gene encoding TamR is oriented ...
Cammaerts Marie-Claire - - 2013
We used the ant species Myrmica sabuleti as a model to study the impact of electromagnetic waves on social insects' response to their pheromones and their food collection. We quantified M. sabuleti workers' response to their trail, area marking and alarm pheromone under normal conditions. Then, we quantified the same ...
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