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Said Neveen N Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia, - - 2013
Secreted protein acidic and rich in cysteine (SPARC) has been implicated in multiple aspects of human cancer. However, its role in bladder carcinogenesis and metastasis are unclear,with some studies suggesting it may be a promoter and others arguing the opposite. Using a chemical carcinogenesis model in Sparc-deficient mice and their ...
Zheng Wei W Department of Cellular and Structural Biology, San Antonio, TX, - - 2013
Glia-based neuroprotection strategies are emerging as promising new avenues to treat brain damage. We previously reported that activation of the glial-specific purinergic receptor, P2Y(1)R, reduces both astrocyte swelling and brain infarcts in a photothrombotic mouse model of stroke. These restorative effects were dependent on astrocyte mitochondrial metabolism. Here, we extend ...
Singh Indrapal N IN Spinal Cord and Brain Injury Research Center (SCoBIRC), Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY, - - 2013
Phenelzine (PZ) is a scavenger of the lipid peroxidation (LP)-derived reactive aldehyde 4-hydroxynonenal (4-HNE) due to its hydrazine functional group, which can covalently react with 4-HNE. In this study, we first examined the ability of PZ to prevent the respiratory depressant effects of 4-HNE on normal isolated brain cortical mitochondria. ...
Singh Tarkeshwar T Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, 44195, USA. - - 2013
We investigated the effects of exercise-induced fatigue of a digit on the biomechanics of a static prehension task. The participants were divided into two groups. One group performed the fatiguing exercise using the thumb (group-thumb) and the second group performed the exercise using the index finger (group-index). We analyzed the ...
Pavilonis Brian T BT Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, USA. - - 2013
The objectives of this study were to characterize rural populations' indoor and outdoor exposure to particulate matter (PM)(10), PM(2.5), and endotoxin and identify factors that influence these concentrations. Samples were collected at 197 rural households over five continuous days between 2007 and 2011. Geometric mean (GM) indoor PM(10) (21.2 μg/m(3)) ...
Cipolla Marilyn J MJ Departments of Neurological Sciences, Obstetrics, Gynecology and Reproductive Sciences, Pharmacology, University of Vermont College of Medicine, Burlington, VT, USA. - - 2013
The adaptation of the cerebral circulation to pregnancy is unique from other vascular beds. Most notably, the growth and vasodilatory response to high levels of circulating growth factors and cytokines that promote substantial hemodynamic changes in other vascular beds is limited in the cerebral circulation. This is accomplished through several ...
Tzatsos Alexandros A Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA. - - 2013
Epigenetic mechanisms mediate heritable control of cell identity in normal cells and cancer. We sought to identify epigenetic regulators driving the pathogenesis of pancreatic ductal adenocarcinoma (PDAC), one of the most lethal human cancers. We found that KDM2B (also known as Ndy1, FBXL10, and JHDM1B), an H3K36 histone demethylase implicated ...
Chen Huadong H Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC, - - 2013
There are limited data on the metabolism of [6]-shogaol (6S), a major bioactive component of ginger. This study demonstrates metabolism of 6S in liver microsomes from mouse, rat, dog, monkey, and human. The in vitro metabolism of 6S was compared among five species using liver microsomes from mouse, rat, dog, ...
King J J Division of Plant and Crop Sciences, School of Biosciences, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK. - - 2013
In many cultivated crop species there is limited genetic variation available for the development of new higher yielding varieties adapted to climate change and sustainable farming practises. The distant relatives of crop species provide a vast and largely untapped reservoir of genetic variation for a wide range of agronomically important ...
Yi Chengqing C Department of Orthopaedics, Shanghai First People's Hospital, No. 650 New Songjiang Road, Shanghai, 201620, China. - - 2013
The aim of this study was to investigate the expression of insulin-like growth factor (IGF)-1 and programmed cell death 5 (PDCD5) in osteoarthritis chondrocytes, and to explore the potential correlation between them in the apoptosis process of osteoarthritis chondrocytes. Patients with knee osteoarthritis were placed into four categories according to ...
Valasek Tamás T Faculty of Health Sciences, Semmelweis University, Vas U. 17, Budapest, 1444, - - 2013
Patient-reported outcome measurements (PROMs) are widely used in spine care. The development of reliable and valid National versions of spine-related disability questionnaires is strongly recommended from both the clinical and scientific points-of-view. The aims of this study were to adapt and validate the Oswestry Disability Index (ODI) and the Quebec ...
Tian-Bi Y-N T YN Laboratoire de Génétique, UFR Biosciences, Université Félix Houphouët-Boigny, 22 BP 1106 Abidjan 22, Côte d'Ivoire. - - 2013
Population differentiation was investigated by confronting phenotypic and molecular variation in the highly selfing freshwater snail Biomphalaria pfeifferi, the intermediate host of Schistosoma mansoni. We sampled seven natural populations separated by a few kilometers, and characterized by different habitat regimes (permanent/temporary) and openness (open/closed). A genetic analysis based on five ...
Bougas B B Département de biologie, Institut de Biologie Intégrative et des Systèmes IBIS, Université Laval, Québec, Canada. - - 2013
Hybridization can lead to phenotypic differences arising from changes in gene expression patterns or new allele combinations. Variation in gene expression is thought to be controlled by differences in transcription regulation of parental alleles, either through cis- or trans-regulatory elements. A previous study among brook charr hybrids from different populations ...
Foulk Michael S MS Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02912, - - 2013
Regulation of DNA replication is critical, and loss of control can lead to DNA amplification. Naturally occurring, developmentally regulated DNA amplification occurs in the DNA puffs of the late larval salivary gland giant polytene chromosomes in the fungus fly, Sciara coprophila. The steroid hormone ecdysone induces DNA amplification in Sciara, ...
Richardson Kelly K KK Comprehensive Access & Delivery Research and Evaluation Center, Iowa City VA Healthcare System, Mailstop 152, 601 Highway West, Iowa City, IA 52246, - - 2013
Hip fracture is a medical emergency for which delayed treatment increases risk of disability and death. In emergencies, veterans without access to a Veterans Administration (VA) hospital may be admitted to non-VA hospitals under fee-based (NVA-FB) care paid by the VA. The affect of NVA-FB care for treatment and outcomes ...
Pruett Brandon S BS Department of Pharmacology, Louisiana State University Health Sciences Center, School of Medicine, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130, - - 2013
Delivery of exogenous glial cell line-derived neurotrophic factor (GDNF) increases locomotor activity in rodent models of aging and Parkinson's disease in conjunction with increased dopamine (DA) tissue content in substantia nigra (SN). Striatal GDNF infusion also increases expression of GDNF's cognate receptor, GFRα1, and tyrosine hydroxylase (TH) ser31 phosphorylation in ...
Pegueroles C C Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain. - - 2013
Gene flow (defined as allele exchange between populations) and gene flux (defined as allele exchange during meiosis in heterokaryotypic females) are important factors decreasing genetic differentiation between populations and inversions. Many chromosomal inversions are under strong selection and their role in recombination reduction enhances the maintenance of their genetic distinctness. ...
de Cara M Á R MÁ Departamento de Mejora Genética Animal, INIA, Madrid, Spain. - - 2013
Conservation programmes aim at minimising the loss of genetic diversity, which allows populations to adapt to potential environmental changes. This can be achieved by calculating how many offspring every individual should contribute to the next generation to minimise global coancestry. However, an undesired consequence of this strategy is that it ...
Morgan Jonathan J JJ Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC, - - 2013
This study represents the first longitudinal, within-subject (1) H MRS investigation of the developing rat brain spanning infancy, adolescence and early adulthood. We obtained neurometabolite profiles from a voxel located in a central location of the forebrain, centered on the striatum, with smaller contributions for the cortex, thalamus and hypothalamus, ...
Kurzius-Spencer Margaret M Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, - - 2013
Chronic exposure to arsenic (As) in food and water is a significant public health problem. Person-specific aggregate exposure is difficult to collect and modeling based on limited food As residue databases is of uncertain reliability. Two cross-sectional population exposure studies, the National Human Exposure Assessment Survey-Arizona and Arizona Border Survey, ...
Groetz Simon F SF Department of Radiology, University Hospital Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn, Germany. - - 2013
To evaluate safety of coblation of simulated lytic metastases in human cadaveric vertebral bodies by measuring heat distribution during thermal tissue ablation and comparing it to radiofrequency ablation (RFA). Three devices were compared: a 10 mm single-needle RFA electrode, a 20 mm array RFA electrode and the coblation device. To ...
Armstrong Katrina K Division of General Internal Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA. - - 2013
After five decades of growth that has included advances in medical education and health care delivery, value cohesion, and integration of diversity, we propose an overarching mission for academic general internal medicine to lead excellence, change, and innovation in clinical care, education, and research. General internal medicine aims to achieve ...
Gong Jicheng J Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, - - 2013
Underlying mechanisms by which air pollutants adversely affect human health remain poorly understood. Oxidative stress has been considered as a potential mechanism that may promote lipid peroxidation by reactive oxygen species, leading to the formation of malondialdehyde (MDA) that is excreted in biofluids (e.g., urine and exhaled breath condensate (EBC)). ...
Shannahan Jonathan H JH Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, - - 2013
In biological environments, nanomaterials associate with proteins forming a protein corona (PC). The PC may alter the nanomaterial's pharmacokinetics and pharmacodynamics, thereby influencing toxicity. Using a label-free mass spectrometry-based proteomics approach, the composition of the PC is examined for a set of nanotubes (NTs) including unmodified and carboxylated single- (SWCNT) ...
Bertrand Todd T Department of Orthopaedics, Duke University Medical Center, Durham, NC 27710, - - 2013
Avascular necrosis (AVN) of the femoral head is a potential complication in patients with slipped capital femoral epiphysis (SCFE), radiographically occurring in 3-60%. This may lead to early hip fusion or hip arthroplasty. Free vascularized fibular grafting (FVFG) may provide a reasonable means to preserve the femoral head. We asked: ...
Narasimhan Arunn A Heat Transfer and Thermal Power Laboratory, Indian Institute of Technology Madras, Chennai-600036, India. - - 2013
During retinal surgical treatment often the gel-like vitreous humor is replaced by aqueous substitutes. A two-dimensional computational model is developed for simulating transpupillary thermotherapy (TTT) process in a human eye under post-retinal treatment. The model accounts for natural convection in vitreous humor and the choroidal blood perfusion. Time dependent and ...
Burandt E E Department of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany. - - 2013
AIB1 (amplified in breast cancer 1) is an estrogen receptorα (ERα) co-activator, known to be amplified and overexpressed in a fraction of breast cancers. It has been linked to prognosis and tamoxifen resistance. However, results have been ambiguous. The different functions of AIB1 in ERα-positive and -negative disease are poorly ...
Moya Pablo R PR Laboratory of Clinical Science, NIMH-Intramural Research Program, Bethesda, MD 20819, USA. - - 2013
The recent finding that the neuronal cadherin gene CDH2 confers a highly significant risk for canine compulsive disorder led us to investigate whether missense variants within the human ortholog CDH2 are associated with altered susceptibility to obsessive-compulsive disorder (OCD), Tourette disorder (TD) and related disorders. Exon resequencing of CDH2 in ...
Crane Alice L AL Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, New York, - - 2013
Chlorpyrifos (CPF) is applied seasonally in Egypt by adolescent agricultural workers and the extent of occupational exposure and the potential for environmental CPF exposure in this population is poorly understood. Adolescent pesticide applicators (n=57; 12-21 years of age) and age-matched non-applicators (n=38) from the same villages were followed for 10 ...
Schlösser Magnus - - 2013
Highly accurate, in-line and real-time composition measurements of gases are mandatory in many processing applications. The quantitative analysis of mixtures of hydrogen isotopologues ($\rm{H_2}$, $\rm{D_2}$, $\rm{T_2}$, $\rm{HD}$, $\rm{HT}$ and $\rm{DT}$) is of high importance in such fields as DT fusion, neutrino mass measurements using tritium $\beta$-decay or photonuclear experiments where ...
Kauppinen Ari - - 2013
Until recently, the freeze-drying process and formulation development have suffered from a lack of micro-scale analytical tools. Using such an analytical should decrease the required sample volume and also shorten the duration of the experiment compared to a laboratory scale setup. This study evaluated the applicability of Raman spectroscopy for ...
Hlubocky Fay J - - 2013
ABSTRACT Despite the recent advances in cancer therapeutics for Lymphoma (Lym), a continuum of disease, treatment, and psychological challenges remain for the clinical management of the Lym patient adversely impacting health-related quality of life. In response, this study presents the development and validation of the NCCN-FACT Lymphoma Symptom Index-18 (FLymSI-18). ...
Alvarado Anthony S - - 2013
We report 3 cases of Clostridium difficile-associated hemolytic uremic syndrome (HUS) with biopsy proven renal thrombotic microangiopathy. Two patients with acute renal failure were kidney transplants recipients whereas the third patient developed renal failure in the native kidneys. The presentation was preceded by acute diarrhea and stool. Clostridium difficile toxin ...
Lee Li-Hui - - 2013
Personal Health Record systems (PHRs) provide opportunities for patients to access their own PHR. However, PHRs are teeming with medical terminologies, such as disease and symptom names, etc. Patients need readily understandable and useful health knowledge in addition to their records in order to enhance their self-care ability. This study ...
Szmigielski Stanislaw - - 2013
For years, radiofrequency (RF) and microwave (MW) radiations have been applied in the modern world. The rapidly increasing use of cellular phones called recent attention to the possible health risks of RF/MW exposures. In 2011, a group of international experts organized by IARC (International Agency for Research on Cancer in ...
Tvarijonaviciute A - - 2013
The objective of this study was to evaluate and compare different sample treatments and storage conditions in order to determine optimal conditions for total and acylated canine ghrelin measurement using ELISA assays. Under the conditions assessed in this study, total ghrelin concentration was stable when stored at room temperature or ...
Liu Chun-Ming - - 2013
In recent years, peptide hormones have been recognized as important signal molecules in plants. Genetic characterization of such peptides is challenging since they are usually encoded by small genes. As a proof of concept, we used the well-characterized stem cell-restricting CLV3 to develop an antagonistic peptide technology by transformations of ...
Kikuchi Azusa - - 2013
The excited states of UV-B absorber, 4-methylbenzylidenecamphor (MBC) have been studied through measurements of UV absorption, phosphorescence, triplet-triplet (T-T) absorption, and steady-state and time-resolved electron paramagnetic resonance spectra in ethanol. The energy level and lifetime of the lowest excited triplet (T1) state of MBC were determined. The energy level of ...
James Matthew T - - 2013
BACKGROUND: CONTRAST-INDUCED ACUTE KIDNEY INJURY (CI-AKI) HAS BEEN ASSOCIATED WITH MORTALITY, ALTHOUGH IT HAS BEEN SUGGESTED THIS ASSOCIATION MAY BE ATTRIBUTABLE TO CONFOUNDING. WE PERFORMED A SYSTEMATIC REVIEW AND META-ANALYSIS TO CHARACTERIZE THE ASSOCIATIONS BETWEEN CI-AKI AND SUBSEQUENT CLINICAL OUTCOMES.METHODS AND RESULTS: WE IDENTIFIED STUDIES USING MEDLINE (1950 TO JUNE ...
Wang Youbin - - 2013
Objective :  Minor cleft lip deformities are also called lesser-form cleft lips. A furrowed philtral column is one of the important characters of these deformities. Many surgical methods have been adopted to correct it with less than satisfactory results. In this article, a dermis reconstructive method was introduced. Patients :  ...
Sivanandan Sindhu - - 2013
Objective To compare the incidence of medical closure of patent ductus arteriosus (PDA) and adverse events (acute renal dysfunction, necrotizing enterocolitis, spontaneous intestinal perforation, and gastrointestinal bleeding) between preterm infants who received indomethacin and ibuprofen for the treatment of PDA.Study Design A retrospective comparative effectiveness evaluation study was conducted on preterm infants ...
Romero Isabella S - - 2013
To produce conductive, biocompatible, and mechanically robust materials for use in bioelectrical applications, we have developed a new strategy to selectively incorporate poly(pyrrole) (Ppy) into constructs made from silk fibroin. Here, we demonstrate that covalent attachment of negatively charged, hydrophilic sulfonic acid groups to the silk protein can selectively promote ...
Gagnon Kevin J - - 2013
The structural change and resilience of a single crystal of a metal-organic framework (MOF), Zn(HO3PC4H8PO3H) •2H2O (ZAG-4), was investigated under high pressures (0 - 9.9 GPa) using in situ single crystal X-ray diffraction. Although the unit cell volume decreases over 27%, the quality of the single crystal is retained and ...
Huynh Alexis K - - 2013
Abstract Optimal adherence to antiretroviral therapy (ART) is essential for reducing mortality and morbidity in persons living with HIV/AIDS (PLWHA), as well as for reducing the risk of further HIV transmission. While studies have identified psychosocial factors such as lack of social support and poor mental health status as important ...
Chisada Shin-Ichi - - 2013
Vibrios, distributed in marine and brackish environments, can cause vibriosis in fish and shellfish under appropriate conditions. Previously, we clarified by thin-layer chromatography (TLC) overlay assay that (35) S-labeled Vibrio trachuri adhered to GM4 isolated from red sea bream intestine (Chisada et al. Biochem. Biophys. Res. Commun. 333, 367-373, 2005). ...
Han Na-Young - - 2013
OBJECTIVE: Inflammatory bowel disease (IBD) is a disease showing relapsing and remitting inflammatory courses of the colon and small intestine, mostly Crohn's disease (CD) and ulcerative colitis (UC). Biomarkers discriminating UC and CD, especially in cases with indeterminate type, and reflecting disease activities are still lacking, but advanced technology of ...
Yamada T - - 2013
Background and study aims: Acute colorectal obstruction (ACO) often accompanies colorectal cancer (CRC) and requires urgent treatment, but achieving elective laparoscopy-assisted colectomy (LAC) is difficult in this setting. The aim of the current study was to assess the clinical outcomes of a transanal tube (Dennis colorectal tube [DCT]) for CRC ...
Gleeson Michael - - 2013
BACKGROUND: Falls are an increasingly important and costly public health problem. Vision is key to postural stability as we age and this puts adults with visual impairments at greater risk of falls. Physical interventions improve balance in the general population and in older adults with visual impairments in residential care. ...
Azagba Sunday - - 2013
INTRODUCTION: Smoking susceptibility in early adolescence is strongly predictive of subsequent smoking behavior in youth. As such, smoking susceptibility represents a key modifiable factor in reducing the onset of smoking in young people. A growing literature has documented a number of factors that influence susceptibility to smoking; however, there is ...
Huang Hao - - 2013
Multiple antibiotic resistance regulator (MarR) family transcriptional regulators usually regulate gene activity by responding to specific ligands. Here we show that TamR (trans-aconitate methyltransferase regulator), a MarR homolog from Streptomyces coelicolor, functions in oxidative stress responses to regulate a key step in central metabolism. The gene encoding TamR is oriented ...
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