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Results 501 - 550 of 2388
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Toft Andrew A Spinal Cord Group, Institute of Neuroscience & Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United - - 2013
Cell transplantation is one strategy for encouraging regeneration after spinal cord injury and a range of cell types have been investigated for their repair potential. However, variations in study design complicate determination of which cells are most effective. In this study we have carried out a direct comparison of the ...
Ayuso Carmen C 1] Department of Genetics, IIS-Jimenez Diaz Foundation (IIS-FJD), Madrid, Spain [2] Centre for Biomedical Network Research on Rare Diseases CIBERER ISCIII, Valencia, - - 2013
The development of new massive sequencing techniques has now made it possible to significantly reduce the time and costs of whole-genome sequencing (WGS). Although WGS will soon become a routine testing tool, new ethical issues have surfaced. In light of these concerns, a systematic review of papers published by expert ...
Gao Yi - - 2013
The endosperm plays an important role in seed formation and germination, especially in rice (Oryza sativa). We used a high-throughput sequencing technique (RNA-Seq) to reveal the molecular mechanisms involved in rice endosperm development. Three cDNA libraries were taken from rice endosperm at 3, 6 and 10 days after pollination (DAP), which ...
Morgan Jonathan J JJ Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC, - - 2013
This study represents the first longitudinal, within-subject (1) H MRS investigation of the developing rat brain spanning infancy, adolescence and early adulthood. We obtained neurometabolite profiles from a voxel located in a central location of the forebrain, centered on the striatum, with smaller contributions for the cortex, thalamus and hypothalamus, ...
Stoffel Karl K - - 2013
BACKGROUND: Previous studies comparing unipolar and bipolar hemiarthroplasty for treatment of displaced intracapsular femoral neck fractures in elderly patients have often lacked methodological power and yielded conflicting clinical results. The objective of this study was to compare the clinical outcomes from each implant in a randomized cohort of elderly patients ...
Navigante A - - 2013
OBJECTIVE: This study aims to determine the relationship between weakness and bioimpedance analysis (BIA)-derived phase angle in a population of untreated cancer patients with fatigue. METHODS: We prospectively evaluated 41 treatment-naive cancer patients of several origins that presented with performance status 1-2, weight loss >5 % in the last 6 months, and ...
Demir Ozlem - - 2013
Elk-1 is a member of the E-twenty-six (ETS) domain superfamily of transcription factors and has been traditionally associated with mitogen-induced immediate early gene transcription upon phosphorylation by mitogen activated protein kinases (ERK/MAPK). Elk-1 is not only upregulated but also phosphorylated in brain tumour cells. However, in this study, we show ...
Neller Daniel J - - 2013
Users of commonly employed actuarial risk assessment instruments (ARAIs) hope to generate numerical probability statements about risk; however, ARAI manuals often do not explicitly report data that are essential for understanding the classification accuracy of the instruments. In addition, ARAI manuals often contain data that have the potential for misinterpretation. ...
Kim Bora - - 2013
Activation of the pregnane X receptor (PXR) alters the expression of metabolic enzymes and transporters involved in the metabolism of xenobiotics and endobiotics. To identify endogenous biomarkers of PXR activation in humans, rifampin, a strong PXR activator, was administered to 12 healthy male subjects, and their urine was analyzed before ...
Jianwei Zhu - - 2013
Kruppel-like factor 6 (KLF6) is a tumor suppressor gene frequently downregulated in a number of human cancers, including osteosarcoma. However, the role of KLF6 in osteosarcoma remains unclear. This study was aimed at investigating the effects of KLF6 on osteosarcoma cell biological behavior. First, the expression of KLF6 in osteosarcoma ...
Jilma-Stohlawetz Petra - - 2013
BACKGROUND: Octaplas LG is a prion-depleted version of a previous generation product called Octaplas S/D. We compared the recovery, safety, and tolerability of these two pharmaceutical-grade plasmas. STUDY DESIGN AND METHODS: In this comparative, block-randomized, open-label, active-controlled, crossover Phase I trial, 60 healthy adult volunteers received single transfusions of 1200 mL ...
Liu J - - 2013
Total five ear skin fibroblast lines (named F1, F2, F3, F4 and F5) from different newborn Holstein cows have been used as nuclear donor cells for producing cloned cows by somatic cell nuclear transfer (SCNT). The effects of these cell lines on both in vitro and in vivo developmental rates ...
Glannon Walter - - 2013
Neuromodulation consists in altering brain activity to restore mental and physical functions in individuals with neuropsychiatric disorders and brain and spinal cord injuries. This can be achieved by delivering electrical stimulation that excites or inhibits neural tissue, by using electrical signals in the brain to move computer cursors or robotic ...
Todorovic Slobodan M - - 2013
Pain is an important clinical problem and, in its chronic form, may be a disabling condition. Most currently available therapies are insufficient and/or accompanied by serious side effects. Recent studies have implicated the Ca(V)3.2 isoform of T-type Ca channels in nociceptive signaling. Ca(V)3.2 channels are located in the somas of ...
Fan Wenqing - - 2013
Semiconductor-based photocatalysis has attracted much attention in recent years because of its potential for solving energy and environmental problems that we are now facing. Among many photocatalytic reactions, the splitting of H(2)O into H(2) and O(2) and the reduction of CO(2) with H(2)O into organic compounds such as CH(4) and ...
Foulk Michael S MS Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02912, - - 2013
Regulation of DNA replication is critical, and loss of control can lead to DNA amplification. Naturally occurring, developmentally regulated DNA amplification occurs in the DNA puffs of the late larval salivary gland giant polytene chromosomes in the fungus fly, Sciara coprophila. The steroid hormone ecdysone induces DNA amplification in Sciara, ...
Uclés A - - 2013
This work introduces a liquid chromatography-electrospray ionization-hybrid quadrupole/time-of-flight mass spectrometry (LC-ESI-QTOF-MS)-based method for qualitative and quantitative analysis of poly(amidoamine) (PAMAM) dendrimers of generations 0 to 3 in an aqueous matrix. The multiple charging of PAMAM dendrimers generated by means of ESI has provided key advantages in dendrimer identification by assignation ...
Kumar K J Senthil - - 2013
Gallic acid (GA) is a phenolic compound, which has been reported to suppress melanogenesis in melanoma cells. However, the molecular mechanism underlying this inhibitory effect was poorly understood. In this article, we revealed that GA down-regulated melanogenic regulatory genes including tyrosinase, tyrosinase related protein-1 (TRP-1), and dopachrome tatamerase (Dct) expression ...
Jenei Zsigmond M ZM 3rd Department of Internal Medicine, Semmelweis University Budapest, Budapest, Hungary. - - 2013
Predicting the prognosis of comatose, post-cardiac-arrest patients is a complex problem in clinical practice. There are several established methods to foretell neurological outcome; however, further prognostic markers are needed. HSP70 (HSPA1A), which increases rapidly in response to severe stress (among others after ischemic or hypoxic events), is a biomarker of ...
Oliynyk Vitaliy - - 2013
We report a robust and versatile membrane protein based system for selective uptake and release of ions from nanoporous particles sealed with ion-tight lipid bilayers of various compositions that is driven by the addition of ATP or a chemical potential gradient. We have successfully incorporated both a passive ion channel-type ...
Yong Jean H E - - 2013
BACKGROUND: Cost-effectiveness evidence is increasingly considered in the reimbursement decisions of pharmaceuticals. In some jurisdictions such as the UK and Canada, pharmaceutical manufacturers are required to submit economic evaluations when seeking reimbursement. OBJECTIVES: Our objectives were to describe the role of economic evidence in the cancer drug review process in ...
Chito Diana - - 2013
The complexing capacity of synthetic (tartrate 0.011 M in 13.5% ethanol) and real wine (Raimat Abadia) in titrations with added total Zn concentrations up to 0.03 M has been determined following the free Zn concentrations with AGNES (Absence of Gradients and Nernstian Equilibrium Stripping) technique. A correction to find the ...
Ying Xiaofang - - 2013
Identification of high-risk prognostic markers for stage II colorectal cancer (CRC) is currently a big challenge. CD133 is one of the most commonly used CRC stem cell markers. However, its specificity is controversial. Recent studies have demonstrated that the AC133 epitope of CD133, not the CD133 protein, is responsible for ...
Reid Rachel O RO Centers for Medicare & Medicaid Services, Center for Medicare & Medicaid Innovation, Rapid-Cycle Evaluation Group, Baltimore, MD 21244, - - 2013
The US Centers for Medicare & Medicaid Services publishes star ratings reflecting Medicare Advantage plan quality to inform enrollment decisions. To assess the association between publicly reported Medicare Advantage plan quality ratings and enrollment. Cross-sectional study of 2011 Medicare Advantage enrollments among 952,352 first-time enrollees and 322,699 enrollees switching plans. ...
Ahn Jinho - - 2013
Amide-linked tripyridine derivatives , with a para-substituent, and , with a meta-substituent, were gelated in water or water-DMSO. The gelation capabilities of and were attributed to the cooperative effects of mainly CH-π and π-π stacking or strong intermolecular hydrogen bonding interactions between the amide groups. The fluorescence properties of gels ...
Thiem Stefan - - 2013
Gastrointestinal cancers are frequently associated with chronic inflammation and excessive secretion of IL-6 family cytokines, which promote tumorigenesis through persistent activation of the GP130/JAK/STAT3 pathway. Although tumor progression can be prevented by genetic ablation of Stat3 in mice, this transcription factor remains a challenging therapeutic target with a paucity of ...
Yuan Yiyang - - 2013
Transgenic rice expressing Bacillus thuringiensis (Bt) endotoxins (Bt rice) for pest control is considered an important solution to food security in China. However, tests for potential effects on non-target soil organisms are required for environmental risk assessment. The soil collembolan Folsomia candida L. (Collembola: Isotomidae) is a potential non-target arthropod ...
Kwint Henk-Frans - - 2013
BACKGROUND: Many studies have investigated the effect of medication review on a variety of outcomes, but the elements of the interventions have been quite diverse. Moreover, implementation rates of recommendations also vary widely between studies. OBJECTIVE: The objective of this study was to investigate how the extent of collaboration between ...
Adappa Nithin D - - 2013
BACKGROUND: We recently demonstrated the bitter taste receptor T2R38 upregulates sinonasal mucosal innate defense in response to gram-negative quorum-sensing molecules through increased nitric oxide production and mucociliary clearance. T2R38 was initially identified in the quest to understand the variability in bitter taste perception to the compound phenylthiocarbamide (PTC) and demonstrated ...
Gisondi P - - 2013
BACKGROUND: Chronic plaque psoriasis is frequently associated to metabolic disorders including obesity. Anti-TNF-alpha treatments can induce body weight increase in patients with psoriasis. Information on the effect of ustekinumab on the body weight is not available. OBJECTIVE: To investigate whether therapy with ustekinumab is associated with changes in body mass ...
Mitchell Anna L - - 2013
OBJECTIVE: This case series documents the response of nine individuals with glucocorticoid-refractory Graves' orbitopathy (GO) to B cell depletion therapy with rituximab (RTX). CONTEXT: Graves' disease (GD) is one of the commonest autoimmune conditions and is frequently associated with inflammatory changes around the eyes (GO). GO frequently results in significant ...
Willets Katherine A - - 2013
Super-resolution far-field imaging has recently emerged as a novel strategy for imaging interactions between plasmonic nanostructures and single molecules with spatial resolution <5 nm. In these experiments, the emission centroid of a diffraction-limited spot is modeled as a two-dimensional Gaussian, allowing the position of an emitter to be determined with ...
Qiang Sheng Yang - - 2013
Background/Aims: Diabetes mellitus (DM) has been considered to be relevant to an increased risk of several different types of cancers. However, its relationship with extrahepatic cholangiocarcinoma (ECC) remains unclear. Methodology: To investigate a quantitative assessment of this relationship, we performed a meta-analysis to evaluate the association between diabetes and the ...
Lee Chil Won - - 2013
Benzo[4,5]thieno[2,3-b]pyridine (BTP) was newly developed as an electron deficient moiety for high triplet energy materials and two BTP derivatives with the BTP and carbazole groups were synthesized as high triplet energy bipolar host materials. The BTP derivatives were effective as the host materials for green and blue phosphorescent organic light-emitting ...
Thutupalli Shashi - - 2013
Droplet interface bilayers are a convenient tool to produce and explore lipid membrane properties. We discuss why their formation time in microfluidics can be three to six orders of magnitude faster compared to conventional bulk settings.
Stenhagen Ida S R - - 2013
The Ag-mediated electrophilic [(18)F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [(18)F]selectfluor bis(triflate) in acetone. The process gave 6-[(18)F]fluoro-l-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol(-1).
Azenha Manuel - - 2013
Macromolecules such as polyethylene glycol (PEG) have been frequently used in the preparation of xerogels mainly with the purpose of tuning the meso or macroporosity. However, PEG has never been applied in the context of the preparation of molecularly imprinted xerogels for small molecules. Thus we decided to conduct a ...
Tang Juan - - 2013
Platinum-cerium oxide hybrid nanocatalysts (CeO(2)-Pt) were for the first time designed as bionanolabels for highly efficient electrochemical immunosensing of low-abundance proteins coupling nanocatalyst-based redox cycling with in situ signal amplification strategy.
Robinson Philip C - - 2013
Patient education is an important aspect of gout management, but there is evidence that many patients lack adequate knowledge of their condition. Our aim was to examine the characteristics of gout patient education resources. Ten gout patient information resources were examined for readability (Flesch-Kincaid reading level, the Simple Measure of ...
Szelenyi Istvan - - 2013
Flupirtine was developed long before K(V)7 (KCNQ) channels were known. However, it was clear from the beginning that flupirtine is neither an opioid nor a nonsteroidal anti-inflammatory analgesic. Its unique muscle relaxing activity was discovered by serendipity. In the meantime, broad and intensive research has resulted in a partial clarification ...
Ladak Adil - - 2013
The soleus sling has been recently identified as a site of compression of the tibial nerve resulting in tibial neuropathy. Diagnosis of soleal sling syndrome is difficult, and has been based mainly on clinical examination. Advances in MR imaging with high-resolution 3-Tesla scanners have made direct visualization of nerve pathology ...
Valasek Tamás T Faculty of Health Sciences, Semmelweis University, Vas U. 17, Budapest, 1444, - - 2013
Patient-reported outcome measurements (PROMs) are widely used in spine care. The development of reliable and valid National versions of spine-related disability questionnaires is strongly recommended from both the clinical and scientific points-of-view. The aims of this study were to adapt and validate the Oswestry Disability Index (ODI) and the Quebec ...
Kujawinski Dorothea M - - 2013
The interest in compound-specific isotope analysis for product authenticity control and source differentiation in environmental sciences has grown rapidly during the last decade. However, the isotopic analysis of very polar analytes is a challenging task due to the lack of suitable chromatographic separation techniques which can be used coupled to ...
Hart Stephen D - - 2013
We investigated the precision of individual risk estimates made using actuarial risk assessment instruments (ARAIs) by discussing some major conceptual issues and then illustrating them by analyzing new data. We used a standard multivariate statistical procedure, logistic regression, to create a new ARAI based on data from a follow-up study ...
Ruderfer Douglas M DM Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, - - 2013
Recent reports suggest that somatic structural changes occur in the human genome, but how these genomic alterations might contribute to disease is unknown. Using samples collected as part of the International Schizophrenia Consortium (schizophrenia, n=3518; control, n=4238) recruited across multiple university research centers, we assessed single-nucleotide polymorphism genotyping arrays for ...
Urbin M A MA Department of Kinesiology, Auburn University, Auburn, AL, 36849-5323, USA. - - 2013
This investigation examined whether visual feedback is used to make online adjustments during overarm throwing performance. Eight healthy, college-aged males able to throw in excess of 31.3 m/s with previous baseball pitching experience participated. Subjects performed maximal-effort overarm throws under a pretest condition and three test conditions. Under the randomly presented ...
Pang Hongchang - - 2013
A template-free strategy is exploited to bottom-up synthesize yolk-shell vanadium oxide through a two-step spontaneous assembly of hydrolytically formed subunits in a one-pot process. The unique structured vanadium pentoxide exhibits excellent cathode performance for lithium ion batteries.
On-Yee Chan Anna - - 2013
A new approach for selective modification of cysteine-containing peptides through gold-mediated oxidative allene-thiol coupling reaction in aqueous medium is developed.
Herrick Amy L - - 2013
This commentary presents the content and results of a recent symposium held to discuss how resiliencies among gay and bisexual men, and other men who have sex with men, could inform HIV prevention interventions. We outline the argument for including resiliencies in prevention work and present a critique of the ...
Caglar Erkan - - 2013
Background/Aims: The efficacy of endoscopic ultrasound with fine-needle aspiration (EUS-FNA) in the diagnosis and staging of pancreatic malignancy is quite well established. The aim of this study is to describe a single-centre's experience. Methodology: Data were collected retrospectively on all patients with solid pancreatic masses undergoing EUS-FNA from January 2006 ...
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