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Murakami Ryusuke R Department of Radiology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo Tokyo 1138602, Japan. - - 2013
A study was conducted to evaluate the sensitivity of computer-aided detection (CAD) with full-field digital mammography in detection of breast cancer, based on mammographic appearance and histopathology. Retrospectively, CAD sensitivity was assessed in total group of 152 cases for subgroups based on breast density, mammographic presentation, lesion size, and results ...
Wu Yao Y School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, - - 2013
Efficient segmentation of tumors in medical images is of great practical importance in early diagnosis and radiation plan. This paper proposes a novel semi-automatic segmentation method based on population and individual statistical information to segment brain tumors in magnetic resonance (MR) images. First, high-dimensional image features are extracted. Neighborhood components ...
Soh BaoLin Pauline BP Medical Image Optimisation and Perception Group (MIOPeG), Discipline of Medical Radiation Sciences (C42), University of Sydney, Room M221, Cumberland Campus, Sydney, NSW 2141, Australia. - - 2013
This study measured reading workstation monitors and the viewing environment currently available within BreastScreen New South Wales (BSNSW) centres to determine levels of adherence to national and international guidelines. Thirteen workstations from four BSNSW service centres were assessed using the American Association of Physicists in Medicine Task Group 18 Quality ...
Gray Clark C Department of Geography, University of North Carolina, Chapel Hill, NC 27599-3220, USA. - - 2013
The question of whether environmental conditions influence human migration has recently gained considerable attention, driven by claims that global environmental change will displace large populations. Despite this high level of interest, few quantitative studies have investigated the potential effects of environmental factors on migration, particularly in the developing world and ...
Mahapatra Dwarikanath D Department of Computer Science, Swiss Federal Institute of Technology (ETH), CAB F 61.1, Universitätstrasse 6, 8092 Zurich, Switzerland. - - 2013
In this paper, we propose a novel method for segmentation of the left ventricle, right ventricle, and myocardium from cine cardiac magnetic resonance images of the STACOM database. Our method incorporates prior shape information in a graph cut framework to achieve segmentation. Poor edge information and large within-patient shape variation ...
Okuno Yusuke Y Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, - - 2013
We identified CD8(+)  CD122(+) regulatory T cells (CD8(+)  CD122(+) Treg cells) and reported their importance in maintaining immune homeostasis. The absence of CD8(+)  CD122(+) Treg cells has been shown to lead to severe systemic autoimmunity in several mouse models, including inflammatory bowel diseases and experimental autoimmune encephalomyelitis. The T-cell receptors ...
Hu Xintao X School of Automation, Northwestern Polytechnical University, Xi'an, - - 2013
In the human brain, functional activity occurs at multiple spatial scales. Current studies on functional brain networks and their alterations in brain diseases via resting-state functional magnetic resonance imaging (rs-fMRI) are generally either at local scale (regionally confined analysis and inter-regional functional connectivity analysis) or at global scale (graph theoretic ...
Rutherford Bret R BR Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, USA. - - 2013
Placebo response in clinical trials of antidepressant medications is substantial and has been increasing. High placebo response rates hamper efforts to detect signals of efficacy for new antidepressant medications, contributing to trial failures and delaying the delivery of new treatments to market. Media reports seize upon increasing placebo response and ...
Scheinost Dustin D Department of Biomedical Engineering, Yale University, New Haven, CT 06510, USA. - - 2013
Real-time functional magnetic resonance imaging (rt-fMRI) has recently gained interest as a possible means to facilitate the learning of certain behaviors. However, rt-fMRI is limited by processing speed and available software, and continued development is needed for rt-fMRI to progress further and become feasible for clinical use. In this work, ...
Manini A F AF Division of Medical Toxicology, Department of Emergency Medicine, Mount Sinai School of Medicine, Elmhurst Hospital Center, New York, NY 10029, USA. - - 2013
Genetic variations in the human mu-opioid receptor gene (OPRM1) mediate individual differences in response to pain and opiate addiction. We studied whether the common A118G (rs1799971) mu-opioid receptor single nucleotide polymorphism (SNP) was associated with overdose severity in humans. In addition, we examined an SNP responsible for alternative splicing of ...
Muravyeva Maria M Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, - - 2013
Cardiac mitochondria and the sarcolemmal (sarc)KATP channels contribute to cardioprotective signaling of anesthetic-induced preconditioning. Changes in mitochondrial bioenergetics influence the sarcolemmal ATP-sensitive K (sarcKATP) channel function, but whether this channel has impacts on mitochondria is uncertain. We used the mouse model with deleted pore-forming Kir6.2 subunit of sarcKATP channel (Kir6.2 ...
Patel Vishal N - - 2013
Acute ischemic stroke carries high morbidity and mortality. The advent of intravenous thrombolysis and endovascular reperfusion techniques have helped improve clinical outcomes for patients with large vessel acute ischemic stroke. The care of the post-endovascular stroke patient is complex and encompasses almost all aspects of medicine. Hemodynamics should be optimized ...
Pearson Rebecca M RM Academic Unit of Psychiatry, Oakfield House, Oakfield Grove, University of Bristol, Bristol, UK. - - 2013
Understanding the origins of negative cognitive style could provide a means to prevent adult depression. Cognitive style is an important target for intervention because although it is not possible to remove the stress and adversities in people's lives, it may be possible to modify interpretation of such adversities through cognitive ...
Bai Qiang Q CHU Montpellier, SAFE-IPS Reprogramming Platform, Institute of Research in Biotherapy, Montpellier, F34000 - - 2013
Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) are two types of pluripotent stem cells that hold great promise for biomedical research and medical applications. iPSCs were initially favorably compared to ESCs. This view was first based on ethical arguments (the generation of iPSCs does not require the ...
Solary Eric E Institut Gustave Roussy, Villejuif cedex, France. - - 2013
Tubulin-binding agents are potent cytotoxic drugs that are largely used to treat haematological malignancies and solid tumours. In this issue of British Journal of Pharmacology, doxorubicin was shown to decrease the activity of vincristine when administered simultaneously, unless cell cycle arrest mechanisms were disrupted. This observation emphasizes the need to ...
Caplan David D Neuropsychology Laboratory, Department of Neurology, Massachusetts General Hospital, 175 Cambridge Street, Suite 340, Boston, MA 02114, USA. - - 2013
Efforts to characterize the memory system that supports sentence comprehension have historically drawn extensively on short-term memory as a source of mechanisms that might apply to sentences. The focus of these efforts has changed significantly in the past decade. As a result of changes in models of short-term working memory ...
Yang Xi-Ming XM Department of Physiology, MSB 3050, University of South Alabama College of Medicine, Mobile, AL 36688, - - 2013
Recent studies in rabbits have demonstrated that platelet P2Y12 receptor antagonists are cardioprotective, and that the mechanism is surprisingly not related to blockade of platelet aggregation but rather to triggering of the same signal transduction pathway seen in pre- and postconditioning. We wanted to determine whether this same cardioprotection could ...
Kornfield Rachel R Institute for Health Research and Policy, University of Illinois at Chicago, Westside Research Office Bldg., 1747 West Roosevelt Rd., Chicago, IL 60608, USA. - - 2013
This study assessed the effect of public health advisories issued between 2005 and 2007 by the U.S. Food and Drug Administration (FDA) on treatments of attention-deficit hyperactivity disorder (ADHD) and physician prescribing practices. Data obtained from the IMS Health National Disease and Therapeutic Index, a nationally representative audit of ambulatory ...
Kendler Kenneth S KS Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, USA. - - 2013
Early onset of regular smoking is associated with an elevated risk for later nicotine dependence. Whether or not this association is causal is unknown and has substantial public policy implications. The authors used a monozygotic co-twin control study design. Pairs were selected from the Virginia Adult Twin Study of Psychiatric ...
Lubik Amy A - - 2013
IGF2 is a mitogenic foetal growth factor commonly over-expressed in cancers, including prostate cancer (PC). We recently demonstrated that insulin can activate de novo steroidogenesis in PC cells, a major pathway for reactivation of androgen pathways and PC progression. IGF2 can activate the IGF1 receptor (IGF1R) or insulin receptor (INSR) ...
Ter-Minassian Monica M Department of Medical Oncology, Dana-Farber Cancer Institute, Dana 1250, 450 Brookline Avenue, Boston, MA 02215, USA. - - 2013
The rarity of neuroendocrine tumors (NET) has contributed to a paucity of large epidemiologic studies of patients with this condition. We characterized presenting symptoms and clinical outcomes in a prospective database of over 900 patients with NET. We used data from patient questionnaires and the medical record to characterize presenting ...
Roychowdhury Sanjoy S Departments of Pathobiology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, OH, USA. - - 2013
Hepatocyte cell death via apoptosis and necrosis are major hallmarks of ethanol-induced liver injury. However, inhibition of apoptosis is not sufficient to prevent ethanol-induced hepatocyte injury or inflammation. Because receptor-interacting protein kinase (RIP) 3-mediated necroptosis, a nonapoptotic cell death pathway, is implicated in a variety of pathological conditions, we tested ...
Vosburg Suzanne K SK Division on Substance Abuse, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA. - - 2013
To examine whether tamper-resistant formulations (TRFs) of tapentadol hydrochloride extended-release (ER) 50 mg (TAP50) and tapentadol hydrochloride 250 mg (TAP250) could be converted into forms amenable to intranasal (study 1) or intravenous abuse (study 2). Randomized, repeated-measures study designs were employed. A non-TRF of OxyContin® 40 mg (OXY40) served as a positive control. ...
Li Jingmei J Human Genetics, Genome Institute of Singapore, Singapore, - - 2013
There is experimental evidence that calcium protects against breast cancer development. Prospective epidemiologic studies supporting a protective effect of calcium on breast cancer risk have mainly been limited to Western populations. We examined the association between calcium intake and breast cancer risk in the Singapore Chinese Health Study, a large ...
Xie Yufen Y Department of Obstetrics and Gynecology, C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI 48201, - - 2013
The AMP-activated protein kinase (AMPK) mediates rapid, stress-induced loss of the inhibitor of differentiation (Id)2 in blastocysts and trophoblast stem cells (TSC), and a lasting differentiation in TSC. However, it is not known if AMPK regulates other potency factors or regulates them before the blastocyst stage. The caudal-related homeodomain protein ...
Kadiyala Irina - - 2013
This paper provides an overview of current formulation approaches to mitigate toxicity of orally administrated drugs. The formulation approaches are characterized by their intended impact on a drug's pharmacokinetic parameters, pharmacological properties or metabolic pathways. Regulatory opportunities and constraints with focus on U.S. regulations in optimizing a drug's safety or ...
Jäderling Gabriella - - 2013
To evaluate characteristics and outcome of ICU patients admitted from general wards based on mode of admittance, via a rapid response team or conventional contact. Observational prospective study. General ICU of a university hospital. : A total of 694 admissions to ICU from general wards. None. Between 2007 and 2009, ...
Scholl Ute I - - 2013
Primary aldosteronism is a major cause of secondary hypertension worldwide. This review describes the recent studies that have provided dramatic new insight into the pathogenesis of aldosterone-producing adenomas (APAs) and inherited primary aldosteronism, revealing the role of mutations in the potassium channel KCNJ5 in these disorders. Either of two somatic ...
Kristensen Bo S BS Department of Anaesthesiology and Intensive Care, Aarhus University Hospital Skejby, Skejby, Aarhus, Denmark. - - 2013
The effectiveness of postoperative analgesia through a wound catheter is subject to considerable debate. To test the hypothesis that local wound infusion with bupivacaine followed by continuous infusion could reduce postoperative need for opioids in patients undergoing retropubic prostatectomy. Single-centre prospective, double-blinded, placebo-controlled trial. A major university hospital in Denmark. ...
Ross Randal G RG Department of Psychiatry, Obstetrics and Gynecology, University of Colorado Denver, Aurora, USA. - - 2013
Deficient cerebral inhibition is a pathophysiological brain deficit related to poor sensory gating and attention in schizophrenia and other disorders. Cerebral inhibition develops perinatally, influenced by genetic and in utero factors. Amniotic choline activates fetal α7-nicotinic acetylcholine receptors and facilitates development of cerebral inhibition. Increasing this activation may protect infants ...
Yabluchanskiy Andriy A San Antonio Cardiovascular Proteomics Center, The University of Texas Health Science Center, San Antonio, TX 78245, - - 2013
Myocardial infarction (MI) remains a major cause of morbidity and mortality worldwide. Rapid advances in the treatment of acute MI have significantly improved short-term outcomes in patients, due in large part to successes in preventing myocardial cell death and limiting infarct area during the time of ischemia and subsequent reperfusion. ...
Kucukguven Arda A Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115, - - 2013
Varicose veins (VVs) are a common venous disease of the lower extremity characterized by incompetent valves, venous reflux, and dilated and tortuous veins. If untreated, VVs could lead to venous thrombosis, thrombophlebitis and chronic venous leg ulcers. Various genetic, hormonal and environmental factors may lead to structural changes in the ...
Campbell Kristine A KA University of Utah, Department of Pediatrics, IntermountainInjury Control and Research Center, 295 Chipeta Way, Salt Lake City, UT 84158, USA. - - 2013
OBJECTIVE To describe longitudinal change in child behavior problems associated with resolution of intimate partner violence (IPV) after an investigation for suspected child maltreatment. DESIGN Retrospective cohort study. SETTING The National Survey of Child and Adolescent Well-Being, a nationally representative longitudinal sample of US households investigated for suspected child maltreatment. ...
Chen Wei-Chiang WC Johns Hopkins Physical Sciences-Oncology Center, The Johns Hopkins University, Baltimore, Maryland 21218, - - 2013
Cell cycle distribution of adherent cells is typically assessed using flow cytometry, which precludes the measurements of many cell properties and their cycle phase in the same environment. Here we develop and validate a microscopy system to quantitatively analyze the cell-cycle phase of thousands of adherent cells and their associated ...
Sartor Carolyn E CE Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA. - - 2013
To assess the extent to which the association between childhood sexual abuse (CSA) and early use of alcohol, cigarettes and cannabis in adolescent girls is mediated by risk factors that tend to cluster in families where CSA occurs. An abridged version of the Semi-Structured Assessment for the Genetics of Alcoholism ...
Ballon Jacob J Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, - - 2013
Combining psychotropic medications is common for people diagnosed with schizophrenia facing a variety of clinical circumstances. This review provides an update on evidence regarding the effectiveness of polypharmacy approaches. Epidemiology studies have demonstrated that polypharmacy is extremely common, but evidence regarding all polypharmacy approaches for schizophrenia from randomized controlled trials ...
Sherman Marion E ME VA Gulf Coast Veterans Health Care System, US Department of Veterans Affairs, Biloxi, MS 39531, USA. - - 2013
This study compared causes of death, crude mortality rates, and standardized mortality ratios (SMRs) between decedents with mental illness in Ohio's publicly funded mental health system ("mental illness decedents") and all Ohio decedents. Ohio death certificates and Ohio Department of Mental Health service utilization data were used to assess mortality ...
Gustafson David H DH Center for Health Enhancement Systems Studies, Industrial and Systems Engineering Department, College of Engineering, University of Wisconsin–Madison, 1513 University Avenue, Madison, WI 53706, USA. - - 2013
Improvement collaboratives consisting of various components are used throughout health care to improve quality, but no study has identified which components work best. This study tested the effectiveness of different components in addiction treatment services, hypothesizing that a combination of all components would be most effective. An unblinded cluster-randomized trial ...
Svrakic Dragan M DM Department of Psychiatry, Washington University School of Medicine in St Louis, 660 S Euclid Avenue, Campus Box 8134, St Louis, MO 63110, USA. - - 2013
To systematize existing data and review new findings on the cause of schizophrenia and outline an improved mixed model of schizophrenia risk. Multiple and variable genetic and environmental factors interact to influence the risk of schizophrenia. Both rare variants with large effect and common variants with small effect contribute to ...
Scott Brian J BJ Department of Neurology, University of California-San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA. - - 2013
Central nervous system (CNS) lymphoma can present a diagnostic challenge. Currently, there is no consensus regarding what presurgical evaluation is warranted or how to proceed when lesions are not surgically accessible. We conducted a review of the literature on CNS lymphoma diagnosis (1966 to October 2011) to determine whether a ...
Suflita Michael T MT Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, - - 2013
Skin-derived precursors (SKPs) are an attractive stem cell model for cell-based therapies. SKPs can be readily generated from embryonic and adult mice and adult humans, exhibit a high degree of multipotency, and have the potential to serve as a patient autologous stem cell. The advancement of these cells toward therapeutic ...
Gonzales Ralph - - 2013
National quality indicators show little change in the overuse of antibiotics for uncomplicated acute bronchitis. We compared the effect of 2 decision support strategies on antibiotic treatment of uncomplicated acute bronchitis. We conducted a 3-arm cluster randomized trial among 33 primary care practices belonging to an integrated health care system ...
Akanbi Maxwell O MO APIN Center, Jos University Teaching Hospital, Jos, Nigeria. - - 2013
Our objective was to determine tuberculosis (TB) incidence and evaluate TB risk in adults after one or more years of use of combination antiretroviral therapy (cART) through a retrospective cohort study in Jos, Nigeria. We studied a cohort of HIV-infected adults treated with ART for at least 1 year. Based ...
Ivanov Alexander R AR Barnett Institute of Chemical and Biological Analysis, Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA. - - 2013
Proteomics is a rapidly transforming interdisciplinary field of research that embraces a diverse set of analytical approaches to tackle problems in fundamental and applied biology. This viewpoint article highlights the benefits of interlaboratory studies and standardization initiatives to enable investigators to address many of the challenges found in proteomics research. ...
Jackson Nicola P NP Department of Pathology, University of Cambridge, Cambridge, United - - 2013
Distinct peptide-MHC-II complexes, recognised by Type A and B CD4(+) T-cell subsets, are generated when antigen is loaded in different intracellular compartments. Conventional Type A T cells recognize their peptide epitope regardless of the route of processing, whereas unconventional Type B T cells only recognise exogenously supplied peptide. Type B ...
Levine Hagai H Medical Corps, Israel Defense Force, Israel. - - 2013
Cutaneous melanoma (CM) is a common cancer with increasing incidence in many parts of the world where light-skinned populations live. We conducted a large-scale nationally representative migrant cohort study to assess country of origin and age at migration as predictors of CM, controlling for possible confounders. Data on 1,086,569 Israeli ...
Heitzer Ellen - - 2013
With the increasing number of available predictive biomarkers, clinical management of cancer is becoming increasingly reliant on the accurate serial monitoring of tumor genotypes. We tested whether tumor-specific copy number changes can be inferred from the peripheral blood of patients with cancer. To this end, we determined the plasma DNA ...
Shakeri Ramin R Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, - - 2013
Opium use has been associated with higher risk of cancers of the esophagus, bladder, larynx, and lung; however, no previous study has examined its association with gastric cancer. There is also little information on the associations between hookah (water pipe) smoking or the chewing of tobacco products and the risk ...
Figlin Robert A - - 2013
With the advent of molecularly targeted agents, treatment of metastatic renal cell carcinoma (mRCC) has improved significantly. Agents targeting the vascular endothelial growth factor receptor (VEGFR) and the mammalian target of rapamycin complex 1 (mTORC1) are more effective and less toxic than previous standards of care involving cytotoxic and cytokine ...
Papisov Mikhail I MI Massachusetts General Hospital, Shriners Hospitals for Children-Boston, and Harvard Medical School, 51 Blossom Street, Boston, Massachusetts 02114, United States. - - 2013
Presently, there are no effective treatments for several diseases involving the CNS, which is protected by the blood-brain, blood-CSF, and blood-arachnoid barriers. Traversing any of these barriers is difficult, especially for macromolecular drugs and particulates. However, there is significant experimental evidence that large molecules can be delivered to the CNS ...
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