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Results 301 - 350 of 2924
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Jiang Rongrong - - 2013
The present study investigated the inhibitory effect of cannabidiol (CBD), a major constituent of marijuana, on the catalytic activity of cytochrome P450 2C19 (CYP2C19). (S)-Mephenytoin 4'-hydroxylase activities of human liver microsomes (HLMs) and recombinant CYP2C19 were inhibited by CBD in a concentration-dependent manner (IC(50) = 8.70 and 2.51 µM, respectively). ...
Uto-Kondo Harumi - - 2013
Endothelium-bound extracellular superoxide dismutase (eEC-SOD), a major antioxidative enzyme in the vasculature, is involved in anti-atherogenesis by inhibiting low-density lipoprotein (LDL) oxidation. The objective was to investigate whether the polyphenol-rich juar tea had beneficial effects on LDL oxidation and eEC-SOD levels in patients with metabolic syndrome (MetS). A total of ...
Boormans1 Joost L - - 2013
Molecular classification of ERG-rearranged prostate cancer clarifies the role of TMPRSS2-ERG in the development and progression of prostate cancer. The objective of the present study was to identify direct ERG target genes in ERG-rearranged prostate cancer. Two independent cohorts of primary prostate cancer (cohort A, n=48; cohort B, n=31), a ...
Na Keun - - 2013
Although alpha-fetoprotein is currently the major serologic biomarker for hepatocellular carcinoma (HCC), it cannot efficiently distinguish this cancer from other forms of liver disease in early diagnosis due to its low sensitivity. The aim of this study is to compare human carboxylesterase 1 (hCE1) biomarker sensitivity and specificity versus alpha-fetoprotein ...
Cuddeback Gary S - - 2013
OBJECTIVE: A previous study of a recovery-oriented assertive community treatment initiative (PACT) in Washington State found reductions in state psychiatric hospital use and related costs for PACT participants, especially in the first six months after enrollment and for consumers who were high users of the state psychiatric hospital before ACT ...
Lloret-Linares C - - 2013
Context:The care of patients with hypothalamic obesity is challenging.Objective:To compare body composition, basal metabolic rate (BMR) and metabolic outcomes of adults, with lesional or genetic hypothalamic obesity, with obese patients suffering from primary obesity, once matched for body mass index (BMI).Design and patients:Adults with hypothalamic obesity of genetic origin (Prader ...
Mousavi Seyed Mohsen - - 2013
Background. There are large geographic differences in breast cancer risk but whether survival differs between low- and high-risk groups is less well-established. As the survival of cancer depends on the level of healthcare and awareness of disease risks, subtle differences in cancer biology cannot be revealed in international comparisons. Instead, ...
Böttcher B - - 2013
Abstract Objective: To measure skin thickness in patients with polycystic ovary syndrome (PCOS) in comparison to controls and to examine a possible association with sex steroids, body mass index, lipid profile and hyperinsulinemia. Methods: Thirty patients with confirmed PCOS were compared to thirty-two women presenting for infertility workup. Skin thickness ...
Abdelazim Ibrahim A - - 2013
AIMS: Lower vaginal swabs were collected to compare the intrapartum polymerase chain reaction (PCR) test to the standard antepartum culture for detection of group B streptococcus (GBS) colonisation. MATERIALS AND METHODS: Four hundred and forty-five pregnant women with documented antepartum GBS cultures, who did not receive either antepartum or intrapartum ...
Haga Hans-Jacob - - 2013
This study aims to measure the serum level of 25-hydroxyvitamin D(3) (25-OH-D(3)) in 302 patients with rheumatoid arthritis (RA), studying the association to disease activity. Three hundred two RA patients underwent clinical examination and serological analysis. 25-Hydroxyvitamin D(3) was determined by high-performance liquid chromatography-tandem mass spectrometry. Vitamin D(3) deficiency defined ...
Yang Fan - - 2013
rSj16, a recombined protein from Schistosoma japonicum, has been identified as an anti-inflammatory molecule. In this study, we demonstrated that rSj16 strongly suppressed the growth of murine myeloid leukemia WEHI-3B JCS cells in a dose- and time-dependent manner. rSj16 induced apoptosis by increasing the proportion of sub-G1 apoptotic cells as ...
Mai Zhimao - - 2013
The gene BglNH encoding a β-glucosidase was cloned from a marine streptomycete. Sequence analysis revealed that BglNH encoded a 456-aa peptide with a calculated mass of 51 kDa. The deduced amino acid sequence of BglNH showed the highest identities of 61 % with known β-glucosidases and contained a catalytic domain which belonged ...
Kim H R - - 2013
Study design:A 6-month follow-up study.Objectives:To investigate the outcome of transanal irrigation (TAI) in patients with spinal cord injury (SCI) and to identify factors significantly related to clinical success.Setting:Survey for community-dwelling patients with SCI in South Korea.Methods:Between December 2010 and March 2012, TAI was initiated with 52 patients (41 men; age: ...
Paun Gabriela - - 2013
Abstract This study was meant to determine the inhibitory activity of tannins and flavonoid compounds from Geranium robertianum, Helleborus purpurascens and Hyssopus officinale plant polyphenol rich extracts against urease and α-chymotrypsin. The G. robertianum, H. purpurascens and H. officinale extracts were purified and concentrated by microfiltration and ultrafiltration. Phenolic compounds ...
Sakai Shinji - - 2013
We report a method for preparing cell-laden hydrogel tubes. This method uses a coaxial double-orifice spinneret, simpler than triple-orifice spinnerets which have been used for preparing similar constructs. The intended application was to create a template for preparing filament-like structures composed of two heterogeneous living cell layers. An aqueous solution ...
Olausson E A - - 2013
Background  Scintigraphy, the gold standard to measure gastric emptying, is expensive and not widely available. Therefore, we compared emptying of radiopaque markers (ROM) from the stomach, by use of fluoroscopy, with scintigraphy in patients with insulin-treated diabetes. Methods  On the same day we measured gastric emptying of 20 ROM using ...
Miernyk Karen - - 2013
BACKGROUND: Helicobacter pylori (H. pylori) infection has been correlated with low serum ferritin and iron deficiency. As a secondary analysis of a study of H. pylori reinfection, we investigated the association of H. pylori infection and the effect of its eradication on serum ferritin and iron deficiency. METHODS: Alaska Native adults undergoing esophagogastroduodenoscopy ...
Luykx J J - - 2013
Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype-phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) constitute a potentially informative target for genetic studies of intermediate phenotypes as their genetic underpinnings may elucidate etiological mechanisms. We therefore conducted a genome-wide ...
Jendeberg Anna Lange - - 2013
Background: Community-acquired pneumonia (CAP) is a common and potentially life-threatening infection. Innate immunity is the first line of defence, and antimicrobial peptides (AMPs) produced by white blood cells and at epithelial barriers participate by killing microorganisms and neutralizing bacterial toxins. We wanted to investigate whether concentrations of AMPs (1) are ...
Chang Joe H - - 2013
Background. This study investigates the use of (18)F-fluoromisonidazole (FMISO) PET-guided radiotherapy dose painting for potentially overcoming the radioresistant effects of hypoxia in head and neck squamous cell carcinoma (HNSCC). Material and methods. The study cohort consisted of eight patients with HNSCC who were planned for definitive radiotherapy. Hypoxic subvolumes were ...
Wu Yao - - 2013
Efficient segmentation of tumors in medical images is of great practical importance in early diagnosis and radiation plan. This paper proposes a novel semi-automatic segmentation method based on population and individual statistical information to segment brain tumors in magnetic resonance (MR) images. First, high-dimensional image features are extracted. Neighborhood components ...
Fanélus Irvens - - 2013
The protein L-isoaspartyl methyltransferase (PIMT) repairs damaged aspartyl residues in proteins. It is commonly described as a cytosolic protein highly expressed in brain tissues. Here, we report that PIMT is an active monomeric as well as a multimeric protein in mitochondria isolated from neuroblastoma cells. Upon treatments with mitochondrial uncoupler ...
New P W - - 2013
Study design:Literature review.Objectives:Globally map non-traumatic spinal cord injury (NTSCI) incidence, prevalence, survival, level of injury and aetiology. Propose a research framework for NTSCI prevention and launch a repository of NTSCI data.Setting:Initiative of the International Spinal Cord Society Prevention Committee.Methods:Literature search of Medline and Embase (1959-June 2011). Relevant articles in any ...
Chatterjee Saurav - - 2013
QUESTION Does an integer score based on readily available risk factors predict risk for mortality in patients with heart failure (HF) and reduced or preserved left ventricular ejection fraction (EF)? METHODS DESIGN Collaborative study using individual patient data from 30 cohort studies (median follow-up 2.5 y) participating in the Meta-Analysis ...
Sfondrini Lucia - - 2013
Studies in preclinical models have demonstrated the superior anti-tumor effect of CpGoligodeoxynucleotides (CpG-ODN) when administered at the tumor site rather than systemically. We evaluated the effect of aerosolized CpG-ODN on lung metastases in mice injected with immunogenic N202.1A mammary carcinoma cells or weakly immunogenic B16 melanoma cells. Upon reaching the ...
Mahapatra Dwarikanath - - 2013
In this paper, we propose a novel method for segmentation of the left ventricle, right ventricle, and myocardium from cine cardiac magnetic resonance images of the STACOM database. Our method incorporates prior shape information in a graph cut framework to achieve segmentation. Poor edge information and large within-patient shape variation ...
He Ying - - 2013
Rice glutelin is a multi-subunit storage protein and has high nutritional value. However, many glutelin subunits are still not identified by experiment approach. In this study, a novel subunit (OsGluBX) was discovered by sequence alignment in the UniProtKB database. And then, the OsGluBX of rice from japonica cv. Nipponbare and ...
Tsui Irena - - 2013
PURPOSE:To examine whether clinically significant patent ductus arteriosus (PDA) or indomethacin treatment are associated with plus disease or retinopathy of prematurity (ROP) requiring treatment. METHODS:Retrospective, cross-sectional study. Charts were reviewed for gestational age, birth weight, birth head circumference, birth length, maternal characteristics, gender, bronchopulmonary dysplasia, neurologic comorbidities, PDA and its ...
Dogaris Ioannis - - 2013
Microbial production of ethanol might be a potential route to replace oil and chemical feedstocks. Bioethanol is by far the most common biofuel in use worldwide. Lignocellulosic biomass is the most promising renewable resource for fuel bioethanol production. Bioconversion of lignocellulosics to ethanol consists of four major unit operations: pretreatment, ...
Pluim Dick - - 2013
Pharmacodynamic (PD) analysis requires accurate and precise quantification of enzyme activity targeted by anticancer agents in surrogate cells like peripheral blood mononuclear cells (PBMCs). Enzyme activity is normally reported per mass unit of protein input. However, high and fluctuating hemoglobin (Hb) contamination strongly influences the protein content of PBMC cytosolic ...
Giles L C - - 2013
Objective:Rapid growth, possibly occurring in critical periods in early life, may be important for the development of obesity. It is unknown whether this is influenced by postnatal exposures such as age-relevant sources of stress. Frequent house moves may be one such stressor. We aimed to examine if there is a ...
Jerger James - - 2013
Two quite sensible ways of recording audiometric threshold data emerged in the early 1920s. They were advanced by Edmund Prince Fowler, an otologist, and by Harvey Fletcher, a physicist. Either would probably have been better than the present system, and would have preserved scientific tradition relative to the orientation of ...
Pihlajamaa Tero - - 2013
Thrombospondin-related anonymous protein (TRAP), localized in the micronemes and on the surface of sporozoites of infamous malaria parasite Plasmodium, is a key molecule upon infection of mammalian host hepatocytes and invasion of mosquito salivary glands. TRAP contains two adhesive domains responsible for host cell recognition and invasion, and is known ...
Jones Natalie - - 2013
PTEN plays a well-established role in the negative regulation of the PI3K pathway which is frequently activated in several cancer types, including breast cancer. A nuclear function in the maintenance of chromosomal stability has been proposed for PTEN but is yet to be clearly defined. In order to improve understanding ...
Stanbrook Matthew B - - 2013
QUESTION Is biomarker- or symptom-based adjustment of inhaled corticosteroid (ICS) dose better than physician assessment-based adjustment for preventing treatment failure in adults with mild to moderate asthma? METHODS DESIGN Randomized, placebo-controlled, 3-group trial (Best Adjustment Strategy for Asthma in the Long Term [BASALT] trial). ClinicalTrials.gov NCT00495157. ALLOCATION Unclear allocation concealment.* ...
McIntosh Robert A - - 2013
BACKGROUND: Resting echocardiographic measures of cardiac function such as left ventricular ejection fraction correlate poorly with exercise capacity. Assessment during exercise using measures less dependent on hemodynamic loading conditions, such as tissue Doppler imaging (TDI), may more accurately characterize the relationship between cardiac function and exercise capacity. METHODS AND RESULTS: ...
Tseng L-S - - 2013
Objective: We describe a rare case of sudden onset of unilateral sensorineural hearing loss occurring as the first symptom of moyamoya disease, which is characterised by progressive stenosis of the intracranial internal carotid arteries and their proximal anterior cerebral arteries and middle cerebral arteries. Method: Case report and review of ...
Suchánek Jan - - 2013
The formation of self-assemblies between CdSe quantum dots (QDs) and Zn phthalocyanines (Pc) and azaphthalocyanines (AzaPc) bearing alkylsulfanyl substituents and the photophysical properties of these assemblies were studied using both steady-state and time-resolved luminescence/absorption spectroscopy. The formation of the self-assemblies was accompanied by a blue shift of the Q band ...
Moist Louise - - 2013
QUESTION In adults with type 2 diabetes mellitus, does intensive blood pressure (BP) control improve clinical outcomes more than standard BP control? REVIEW SCOPE Included studies compared antihypertensive therapies to achieve prespecified BP targets in adults who had type 2 diabetes, and assessed ≥ 1 of mortality, myocardial infarction (MI), or ...
Keaveny Eric - - 2013
Recent advances in micro- and nano-scale fabrication techniques allow for the construction of rigid, helically-shaped micro-swimmers that can be actuated using applied magnetic fields. These swimmers represent the first steps toward the development of micro-robots for targeted drug delivery and minimally invasive surgical procedures. To assess the performance of these ...
Cornelius Jan Frederick - - 2013
BACKGROUND: About 90 % of meningiomas are benign (WHO grade I), atypical and anaplastic variants exist (WHO grade II/III, 10 %). Tumour grade has important implications for management. Non-invasive diagnosis of tumour grade is still not feasible. The purpose of this survey was to analyse epidemiological risk factors such as sex, age ...
Williams Monique - - 2013
Abstract Mycobacterium tuberculosis (Mtb) and other members of the Mtb complex possess an expanded complement of genes for the biosynthesis of molybdenum cofactor (MoCo), a tricyclic pterin molecule that is covalently attached to molybdate. This cofactor allows the redox properties of molybdenum to be harnessed by enzymes in order to ...
Giangaspero Massimo - - 2013
A serological survey was carried out in the northern prefectures of Hokkaido, Iwate and Aomori in Japan, for the presence of antibodies against Toxoplasma gondii, Chlamydia psittaci var. ovis, Mycobacterium paratuberculosis, Coxiella burnetii, Brucella spp., Leptospirosis, and orf virus (ORFV). Out of 267 samples tested, highest overall prevalence (28.78%) was ...
Ho Jennifer H - - 2013
High-fat diet (HFD)-induced glucose intolerance and insulin resistance increases the chances of developing type-2 diabetes and cardiovascular disease. To study the mechanism(s) by which a HFD impairs glucose tolerance, we used a quantitative proteomic platform that integrated pI-based OFFGEL fractionation and iTRAQ labeling to profile the temporal changes in adipose ...
Shin Seong Sik - - 2013
Ternary oxides are potential candidates as an electron-transporting material that can replace TiO(2) in dye-sensitized solar cells (DSSCs), as their electronic/optical properties can be easily controlled by manipulating the composition and/or by doping. Here, we report a new highly efficient DSSC using perovskite BaSnO(3) (BSO) nanoparticles. In addition, the effects ...
Rosenblat Mira - - 2013
Abstract In the current study, we analyzed free radicals scavenging activity of monocytes-macrophages in the absence or presence of antioxidants such as polyphenols or paraoxonase 1 (PON1). THP-1 human monocytic cell line, murine J774A.1 macrophages, as well as human primary monocytes have the capability to scavenge free radicals, as measured ...
Guan Shan - - 2013
Abstract Aim: The purpose of this study was to investigate the detailed mechanisms of oral absorption enhancement of bergenin (BN) using BN-phospholipid complex (BPC). Methods: Multiple models such as ex vivo everted rat gut sac model and in vitro Caco-2 cell model were used. Meanwhile, the effect of chitosan on ...
Houyel Lucile - - 2013
Outflow tract defects, including cardiac neural crest defects (so-called conotruncal defects) and transposition of the great arteries, are due to an abnormal rotation of the outflow tract during cardiac development. Coronary orifices are often abnormal in outflow tract defects, particularly in common arterial trunk (CAT). A recent study indicates that ...
Arestedt Liselott - - 2013
AIMS AND OBJECTIVES: The aim of the study was to illuminate the meaning of lived experience of living as a family in the midst of chronic illness. BACKGROUND: Chronic illness implies a change for both the individual and the family. In this changed situation, all family members seem to benefit ...
Mao Kairui - - 2013
Inflammasomes are multi-protein complexes that trigger the activation of caspase-1 and the maturation of interleukin-1β (IL-1β), yet the regulation of these complexes remains poorly characterized. Here we show that nitric oxide (NO) inhibited the NLRP3-mediated ASC pyroptosome formation, caspase-1 activation and IL-1β secretion in myeloid cells from both mice and ...
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