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Results 301 - 350 of 2977
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Bai Jane P F JP Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA. - - 2013
Gene expression is useful for identifying the molecular signature of a disease and for correlating a pharmacodynamic marker with the dose-dependent cellular responses to exposure of a drug. Gene expression offers utility to guide drug discovery by illustrating engagement of the desired cellular pathways/networks, as well as avoidance of acting ...
Majumder Kaustav - - 2013
Egg protein ovotransferrin-derived peptides (IRW and IQW) can attenuate tumor necrosis factor (TNF)-induced inflammatory responses and oxidative stress in endothelial cells. The present study investigates the structural requirements and the molecular mechanisms underlying these events. While IRW significantly inhibited TNF-induced up-regulation of intercellular cell adhesion molecule-I (ICAM-1) and vascular cell ...
Desai Monica Dandona - - 2013
Gastrointestinal (GI) malignancies account for nearly one-fourth of all cancer-related deaths in the United States and approximately 30% of all cancer-related deaths worldwide. Use of combination cytotoxic therapy offers a modest improvement in survival, but the prognosis and long-term survival of most patients with GI cancer remains poor. In certain ...
Watson Melanie - - 2013
BACKGROUND: The economic costs of maternal obesity and underweight have not been described. We aim to assess the effect of maternal underweight and obesity on hospital utilisation and hospital costs. METHODS: Data from the Queensland Perinatal Data Collection and Queensland Hospital Admitted Patient Data Collection were analysed for 2008. The ...
Sunil Thankam S - - 2013
Childhood malnutrition is a major problem in developing countries, and in Cambodia, it is estimated that approximately 42% of the children are stunted, which is considered to be very high. In the present study, we examined the effects of proximate and socio-economic determinants on childhood malnutrition in Cambodia. In addition, ...
Clark Clancy J - - 2013
BACKGROUND: Autoimmune pancreatitis (AIP) is a rare subtype of chronic pancreatitis that may mimic adenocarcinoma of the pancreas. The aim of this study was to evaluate the short-term and long-term outcomes of pancreatectomy for patients with AIP. METHODS: In this multi-institutional study, we identified all patients who underwent pancreatectomy for ...
Pan Jun-Ying - - 2013
Three star-shaped D-A small molecules, (P-DPP)3TPA, (4-FP-DPP)3TPA, and (4-BuP-DPP)3TPA were designed and synthesized with triphenylamine (TPA) as the core, diketopyrrolopyrrole (DPP) as the arm, and unsubstituted or substituted benzene rings (phenyl, P; 4-fluoro-phenyl, 4-FP; 4-n-butyl-phenyl, 4-BuP) as the end-group. All the three small molecules show relatively narrow optical band gaps ...
Foster Paul A - - 2013
AIM: The role of oestrogen metabolism and action in colorectal cancer (CRC) is controversial. An extensive review of the current literature, encompassing epidemiological evidence, systemic and peripheral oestrogen concentrations, 17β-hydroxysteroid dehydrogenase (17β-HSD) and aromatase in CRC, steroid sulphatase (STS)/oestrone sulphotransferase (EST) and in vitro and in vivo genomic effects was ...
Cox Ashley A Division of Urology, University of Toronto, Sunnybrook Health Sciences Centre, Room MG 408, 2075 Bayview Avenue, Toronto, ON M4N 3M5, - - 2013
Many surgical options exist for women with stress urinary incontinence (SUI). The traditional gold standards of Burch retropubic colposuspension and pubovaginal slings are still appropriate treatment options for some patients, but randomized controlled trials have demonstrated that synthetic midurethral slings are just as effective as these traditional procedures but with ...
Buckley Ashura - - 2013
To evaluate for the first night effect (FNE) in a group of young children with autism. Analysis of polysomnographic data from a 2-night sleep laboratory study. Clinical Center of the National Institutes of Health. 15 children (aged 2-10 years) with a diagnosis of an ASD. None. Polysomnographic analysis showed the ...
Wu Meng-Chen MC Department of Neurology, National Taiwan University Hospital, - - 2013
A 60-year-old man with a history of atrial fibrillation had an acute onset of ballistic movements of the left limbs with sensory extinction (video on the Neurology® Web site at www.neurology.org). The patient was treated with risperidone and anticoagulant; symptoms subsided 3 days later. Brain MRI showed acute infarction of ...
Feng Ningdong - - 2013
The origin of the exceptionally high activity of (B, Ag)-codoped TiO2 catalysts under solar-light irradiation has been investigated by XPS and 11B solid-state NMR spectroscopy in conjunction with density functional theory (DFT) calculations. XPS experimental results demonstrated that a portion of the dopant Ag (Ag3+) ions were implanted into the ...
Fu Haoliang - - 2013
The use of multiple-center intramolecular H-bonds for the efficient construction of macrocycles of varying structures and functions is among the newest and the most noteworthy additions to the toolbox for macrocycle synthesis. This strategy has allowed the creation of sizable interior cavities as small as 2.8 Å and as large ...
Skaliczki Gábor G Department of Orthopaedics, Semmelweis University, Karolina út 27, 1113, Budapest, Hungary. - - 2013
Blood-derived proliferative factors such as platelet rich plasma or activated plasma are promising adjuvants for bone grafts. Our earlier studies showed that serum albumin itself can markedly enhance the proliferation of stem cells on bone allograft and postulated that albumin coating alone may improve bone graft integration in vivo. Two ...
Kaylani Samer S Division of Hematology-Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, - - 2013
Infantile hemangiomas (IHs) are common benign tumors of childhood. IHs often regress satisfactorily without intervention, but a subset of IHs may lead to functional or cosmetic morbidity necessitating therapy. PHACE syndrome is characterized by a variety of neurocutaneous and vascular anomalies that typically include segmental hemangiomas. We present an infant ...
Magalhães Pedro - - 2013
Pulse wave velocity (PWV) is an independent predictor of cardiovascular (CV) risk. Higher PWV values have been observed in Africans; however, there are no established age- and gender-adjusted reference values for this population. Therefore, PWV was measured using a validated device (Complior SP) in 544 subjects recruited from an occupational ...
Ryan Emily L EL Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, GA, - - 2013
Classic galactosemia is a potentially lethal disorder that results from profound deficiency of galactose-1-phosphate uridylyltransferase (GALT), the second enzyme in the Leloir pathway of galactose metabolism. Although early diagnosis and rigorous dietary restriction of galactose prevent or resolve the potentially lethal acute symptoms, patients are at markedly increased risk of ...
Idota Yoko - - 2013
Alginate (ALA), which is an intercellular polysaccharide associated with brown algae, is used as a food additive, a health food and a medicine. Here, we first examined the adsorption of strontium (Sr) and cesium (Cs) by ALA in vitro, and then evaluated the effects of ALA on absorption and excretion ...
Dalal Shalini - - 2013
Access to pain relief is a crucial concern for patients with cancer, and remains so at all stages of the illness trajectory. This Review covers the scope of the problem and considers the optimal palliative strategy, mainly through the use of opioids. It also discusses various barriers to effective pain ...
Chatterjee Saurav - - 2013
QUESTION Does an integer score based on readily available risk factors predict risk for mortality in patients with heart failure (HF) and reduced or preserved left ventricular ejection fraction (EF)? METHODS DESIGN Collaborative study using individual patient data from 30 cohort studies (median follow-up 2.5 y) participating in the Meta-Analysis ...
Vats Anima - - 2013
Colon-specific drug delivery systems have recently gained importance for delivering a variety of therapeutic agents via oral route. This mode offers the feasibility of treating colonic pathologies with less risk of bioburden to other organs/tissues and has been widely researched for the delivery of challenging drugs. Microspheres targeted to colon ...
Sfondrini Lucia - - 2013
Studies in preclinical models have demonstrated the superior anti-tumor effect of CpGoligodeoxynucleotides (CpG-ODN) when administered at the tumor site rather than systemically. We evaluated the effect of aerosolized CpG-ODN on lung metastases in mice injected with immunogenic N202.1A mammary carcinoma cells or weakly immunogenic B16 melanoma cells. Upon reaching the ...
Goto Yoshiyuki Y Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, - - 2013
Commensal bacteria regulate the homeostasis of host effector immune cell subsets. The mechanisms involved in this commensal-host crosstalk are not well understood. Intestinal epithelial cells (IECs) not only create a physical barrier between the commensals and immune cells in host tissues, but also facilitate interactions between them. Perturbations of epithelial ...
He Ying - - 2013
Rice glutelin is a multi-subunit storage protein and has high nutritional value. However, many glutelin subunits are still not identified by experiment approach. In this study, a novel subunit (OsGluBX) was discovered by sequence alignment in the UniProtKB database. And then, the OsGluBX of rice from japonica cv. Nipponbare and ...
Tsui Irena - - 2013
PURPOSE:To examine whether clinically significant patent ductus arteriosus (PDA) or indomethacin treatment are associated with plus disease or retinopathy of prematurity (ROP) requiring treatment. METHODS:Retrospective, cross-sectional study. Charts were reviewed for gestational age, birth weight, birth head circumference, birth length, maternal characteristics, gender, bronchopulmonary dysplasia, neurologic comorbidities, PDA and its ...
Feldman Mark - - 2013
Serious, life-threatening conditions may result from too much gastric acid secretion by parietal cells, too little secretion of gastric acid and intrinsic factor by parietal cells, or loss of secreted gastric hydrochloric acid from the body. Understanding the physiology and pathophysiology of gastric secretion and its regulation can improve patient ...
Woo Peter Yat Ming - - 2013
A 45-year-old woman complained of a progressive 2-month history of bilateral hearing impairment and diplopia on upward gaze. She had a history of a recurrent pineal region ganglioglioma with repeated tumor excision, adjuvant radiotherapy, and a ventriculo-peritoneal shunt performed 12 years prior. Subsequent imaging studies 6 years ago showed a ...
Huang Yufang - - 2013
RESP18 (Regulated endocrine-specific protein, 18 kDa) was first identified as a dopaminergic drugs-regulated intermediate pituitary transcript. RESP18 protein is a unique endoplasmic reticulum (ER) resident protein. Its functions in the brain especially in the nervous system disorders remain unknown. ER stress (ERS) has been proved to be one of the important ...
Xu Ming - - 2013
Autism is a developmental disorder affecting communication, social interaction, motor skills, and cerebellar structure and functions. Recent studies have indicated that maternal infection during brain development may be one of the risk factors for autism. We have previously demonstrated the abnormal overexpression of neurotrophin-3 (NT-3) in autistic cerebellum. To examine ...
Burke Matthew D MD GlaxoSmithKline R&D, New Frontiers Science Park, Third Avenue, Harlow, Essex, UK, CM19 5AW. - - 2013
The purpose of this research was to develop a stable fixed dose combination tablet for a model DPP-IV inhibitor and metformin hydrochloride. The dipeptidyl peptidase IV (DPP-IV) inhibitor was particularly challenging to formulate due to its significant chemical instability and moisture sensitivity. Various formulation strategies were investigated and placed on ...
Van Spall Harriette G C - - 2013
QUESTION What is the effectiveness of clinical service interventions in patients previously hospitalized for heart failure (HF)? REVIEW SCOPE Included studies had ≥ 6 months of follow-up and compared clinical service interventions with usual care in patients ≥ 18 years of age who had ≥ 1 previous secondary care admission with HF. Clinical ...
Matsumoto Shuzo - - 2013
The structural feature of unfolding intermediate of pokeweed anti-viral protein (PAP) was characterized using time-resolved fluorescence spectroscopic methods to elucidate protein folding/unfolding process. CD and fluorescence spectra consistently demonstrated that the unfolding of PAP completed at 4 M of guanidine hydrochloride (GuHCl). The fluorescence resonance energy transfer (FRET) and time-resolve fluorescence ...
Rishi Praveen - - 2013
Abstract Emerging drug resistance has forced the scientific community to revisit the observational data documented in the folklore and come up with novel and effective alternatives. Candidates from eukaryotic origin including herbal products and antimicrobial peptides are finding a strategic place in the therapeutic armamentarium against infectious diseases. These agents ...
Dale Gillian - - 2013
When the second of two targets (T2) is presented in close temporal proximity (within 200-500 ms) to the first (T1), the accuracy for reporting T2 is reduced relative to when the targets are separated by longer durations; this effect is known as the attentional blink (AB). Two recent studies have shown ...
Gilgunn Sarah - - 2013
Prostate cancer-the most commonly diagnosed cancer in men worldwide-can have a substantial effect on quality of life, regardless of the route the cancer takes. The serum PSA assay is the current gold standard option for diagnosing prostate cancer. However, a growing body of evidence suggests that PSA screening for prostate ...
Lopatnikova Julia A - - 2013
Abstract Background: Tumor necrosis factor (TNF)-α is an anti-inflammatory cytokine, the biological effects of which are mediated by the interaction with specific membrane-bound receptors. To assess TNF-α receptor (TNFR) expression, it is important to estimate both the number of cells that carry these receptors and the number of receptors per ...
Casanova M J - - 2013
OBJECTIVES:The safety of thiopurines and anti-tumor necrosis factor-α (TNF-α) drugs during pregnancy remains controversial, as the experience with these drugs in this situation is limited. Our aim is to assess the safety of thiopurines and anti-TNF-α drugs for the treatment of inflammatory bowel disease (IBD) during pregnancy.METHODS:Retrospective, multicenter study in ...
Socaci Sonia A - - 2013
INTRODUCTION: The health benefits of sea buckthorn (Hippophae rhamnoides L.) are well documented due to its rich content in bioactive phytochemicals (pigments, phenolics and vitamins) as well as volatiles responsible for specific flavours and bacteriostatic action. The volatile compounds are good biomarkers of berry freshness, quality and authenticity. OBJECTIVE: To ...
Luykx J J - - 2013
Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype-phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) constitute a potentially informative target for genetic studies of intermediate phenotypes as their genetic underpinnings may elucidate etiological mechanisms. We therefore conducted a genome-wide ...
Hirobe Sachiko - - 2013
Vaccination, which is the major fundamental prophylaxis against illness and death from infectious disease, has greatly contributed to the global improvement of human health. However, the disadvantages of conventional injection systems hamper the delivery of vaccination technologies to developing countries. The imminent practice of easy-to-use vaccination methods is expected to ...
Jendeberg Anna Lange - - 2013
Background: Community-acquired pneumonia (CAP) is a common and potentially life-threatening infection. Innate immunity is the first line of defence, and antimicrobial peptides (AMPs) produced by white blood cells and at epithelial barriers participate by killing microorganisms and neutralizing bacterial toxins. We wanted to investigate whether concentrations of AMPs (1) are ...
Chang Joe H - - 2013
Background. This study investigates the use of (18)F-fluoromisonidazole (FMISO) PET-guided radiotherapy dose painting for potentially overcoming the radioresistant effects of hypoxia in head and neck squamous cell carcinoma (HNSCC). Material and methods. The study cohort consisted of eight patients with HNSCC who were planned for definitive radiotherapy. Hypoxic subvolumes were ...
Fanélus Irvens - - 2013
The protein L-isoaspartyl methyltransferase (PIMT) repairs damaged aspartyl residues in proteins. It is commonly described as a cytosolic protein highly expressed in brain tissues. Here, we report that PIMT is an active monomeric as well as a multimeric protein in mitochondria isolated from neuroblastoma cells. Upon treatments with mitochondrial uncoupler ...
New P W - - 2013
Study design:Literature review.Objectives:Globally map non-traumatic spinal cord injury (NTSCI) incidence, prevalence, survival, level of injury and aetiology. Propose a research framework for NTSCI prevention and launch a repository of NTSCI data.Setting:Initiative of the International Spinal Cord Society Prevention Committee.Methods:Literature search of Medline and Embase (1959-June 2011). Relevant articles in any ...
Shin Jin-Hong JH Department of Molecular Microbiology and Immunology, School of Medicine, The University of Missouri, Columbia, Missouri 65212, USA. - - 2013
Dystrophin deficiency results in lethal Duchenne muscular dystrophy (DMD). Substituting missing dystrophin with abbreviated microdystrophin has dramatically alleviated disease in mouse DMD models. Unfortunately, translation of microdystrophin therapy has been unsuccessful in dystrophic dogs, the only large mammalian model. Approximately 70% of the dystrophin-coding sequence is removed in microdystrophin. Intriguingly, ...
Cristofalo Renata - - 2013
Abstract Silibinin is a polyphenolic plant flavonoid with anti-inflammatory properties. The present study investigated the effect of silibinin on oxidative metabolism and cytokine production - tumor necrosis factor-alpha (TNF-α), interleukin (IL)12, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, IL-10, and transforming growth factor beta (TGF-β(1)) - by peripheral blood monocytes (PBM) from ...
Sermkaew Namfa N Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112, - - 2013
Novel self-microemulsifying floating tablets were developed to enhance the dissolution and oral absorption of the poorly water-soluble tetrahydrocurcumin (THC). Their physicochemical properties and THC permeability across Caco-2 cell monolayers were assessed. The self-microemulsifying liquid containing THC was adsorbed onto colloidal silicon dioxide, mixed with HPMC, gas-generating agents (sodium bicarbonate and ...
Bagraith Karl S - - 2013
The objective of this study was to determine whether the International Classification of Functioning, Disability and Health (ICF) and an associated core set are adequate to describe multidisciplinary clinical assessments of patients with chronic musculoskeletal conditions. The multidisciplinary assessment (medical, psychiatry, nursing, physiotherapy, occupational therapy and psychology) of a patient ...
Vlot John - - 2013
BACKGROUND: Adequate working space is a prerequisite for safe and efficient minimal access surgery. No objective data exist in literature about the effect of mechanical bowel preparation (MBP) on working space in laparoscopic surgery. We objectively measured this effect with computed tomography in a porcine laparoscopy model. METHODS: Using standardized ...
Sreejit P - - 2013
Cellular therapy using stem cells for cardiac diseases has recently gained much interest in the scientific community due to its potential in regenerating damaged and even dead tissue and thereby restoring the organ function. Stem cells from various sources and origin are being currently used for regeneration studies directly or ...
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