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Results 201 - 250 of 2977
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Walensky Rochelle P RP Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2013
U.S. HIV treatment guidelines recommend branded once-daily, 1-pill efavirenz-emtricitabine-tenofovir as first-line antiretroviral therapy (ART). With the anticipated approval of generic efavirenz in the United States, a once-daily, 3-pill alternative (generic efavirenz, generic lamivudine, and tenofovir) will decrease cost but may reduce adherence and virologic suppression. To assess the clinical effect, ...
Ter Veld Frank - - 2013
Wickerhamomyces ciferrii secretes tetraacetyl phytosphingosine (TAPS), and in this study, the catalyzing acetyltransferases were identified using mass spectrometry-based proteomics. The proteome of wild-type strain NRRL Y-1031 served as control and was compared to the tetraacetyl phytosphingosine defective mating type NRRL Y-1031-27. Acetylation of phytosphingosine in W. ciferrii is catalyzed by ...
Chiu Li-Fang - - 2013
Infrared microspectroscopy is an emerging approach for disease analysis owing to its capability for in situ chemical characterization of pathological processes. Synchrotron-based infrared microspectroscopy (SR-IMS) provides ultra-high spatial resolution for profiling biochemical events associated with disease progression. Spectral alterations were observed in cultured oral cells derived from healthy, precancerous, primary, ...
Byun W - - 2013
Objective:To determine the association between accelerometry-derived sedentary behavior and body mass index (BMI) z-score in preschool children, and to determine whether the association changed when applying three different accelerometry cutpoints for sedentary behavior.Design and subjects:Cross-sectional design. Data came from two completed studies: Children's Activity and Movement in Preschool Study (CHAMPS) ...
Wang Lijuan - - 2013
The electronic structure and charge transport property of 9,10-distyrylanthracene (DSA) and its derivatives with high solid-state luminescent efficiency were investigated by using density functional theory (DFT). The impact of substituents on the optimized structure, reorganization energy, ionization potential (IP) and electronic affinity (EA), frontier orbitals, crystal packing, transfer integrals and ...
Saito Shuntaro - - 2013
PURPOSE: To develop a general strategy for optimizing monoclonal antibody (MAb) formulations. METHODS: Colloidal stabilities of four representative MAbs solutions were assessed based on the second virial coefficient (B (2)) at 20°C and 40°C, and net charges at different NaCl concentrations, and/or in the presence of sugars. Conformational stabilities were ...
French Jena - - 2013
Background: With our growing understanding of the immune system and mechanisms employed by the tumor to evade destruction, the field of cancer immunotherapy has been revitalized. Concurrent inflammation has long been associated with follicular cell-derived thyroid cancer (FDTC). In the last decade, much research has focused on characterizing the tumor-associated ...
Nicholl David D M - - 2013
Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have a high prevalence of obstructive sleep apnea (OSA) that can have significant clinical implications. An accurate clinical screening tool for OSA that identifies patients for further diagnostic testing would assist in the identification of this comorbidity. The Berlin ...
Xin Che - - 2013
Abstract Background: In the system of the iontophoresis, the external electric field made the ions in the system moving directly, then, the current was generated. Because the current was contributed by all ions in the system, and the small ions with large amount often had higher conductibility than the drug ...
Mourad W F - - 2013
Background: Ceruminous mucoepidermoid carcinoma of the external auditory canal is extremely rare. This paper highlights the impact of concurrent chemoradiotherapy on the outcomes of this disease. Case report: A 47-year-old female presented with a 2-month history of otalgia and a mass in her right ear. Biopsy revealed high grade ceruminous ...
Chamilos Christos - - 2013
INTRODUCTION: Peri/intraventricular hemorrhage (PIVH) is more often seen in premature neonates and can lead to posthemorrhagic hydrocephalus, characterized by high mortality rate and neurodevelopmental delay. CASE REPORT: We report a case of in utero PIVH in a full-term neonate, which led to hydrocephalus. The infant developed at 8 months of gestational ...
Yun Jung-A - - 2013
BACKGROUND: Laparoscopic colectomy for malignancy currently is the standard operative technique together with open colectomy. Single-incision laparoscopic surgery (SIL) is a recent advance in minimally invasive surgical techniques. This study aimed to compare SIL right colectomy with conventional laparoscopy (CL) used to treat patients with colon cancer. METHODS: This study ...
Kazancioglu Hakki Oguz - - 2013
Abstract Objective. This is a questionnaire study aimed to collect information from Turkish dentists and oral and maxillofacial surgeons concerning common occupation-related health problems, their knowledge about these problems and the precautions they commonly took. Study design. This study involved a postal questionnaire survey of oral and maxillofacial surgeons and ...
Kim Tae Hyung - - 2013
PURPOSE:Clinical patterns in pediatric patients with dry eye syndrome and allergic conjunctivitis were investigated. METHODS:Children aged 6 to 15 years with dry eye symptoms were included. Slit-lamp examinations including tear film break-up time, Schirmer's test, and fluorescent staining were performed, and subjective symptoms were investigated. Patients with allergic conjunctivitis were ...
Jovov Biljana B Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7032, USA. - - 2013
Radiofrequency ablation (RFA) of Barrett's esophagus (BE) is a common strategy for the prevention of esophageal adenocarcinoma (EAC). After RFA, the ablated esophagus heals on acid suppressive therapy, and is re-populated with a stratified squamous epithelium, referred to as "neosquamous epithelium (NSE)." Because the ability of the NSE to protect ...
Edwards Jodi D JD School of Population and Public Health, University of British Columbia, Vancouver, - - 2013
To quantitatively characterize domain-specific cognition in individuals with symptomatic lacunar stroke in a systematic review. Systematic searches of MEDLINE and EMBASE were conducted. Inclusion criteria were all articles published prior to December 2011 evaluating domain-specific cognitive status in individuals with a symptomatic lacunar infarct. Data extraction identified cognitive domains with ...
Disterer Petra P Institute for Liver and Digestive Health, UCL, London, - - 2013
Familial hypercholesterolemia (FH) is a genetic disorder characterized by extremely high levels of plasma low-density lipoprotein (LDL), due to defective LDL receptor-apolipoprotein B (APOB) binding. Current therapies such as statins or LDL apheresis for homozygous FH are insufficiently efficacious at lowering LDL cholesterol or are expensive. Treatments that target APOB100, ...
Dogaris Ioannis - - 2013
Microbial production of ethanol might be a potential route to replace oil and chemical feedstocks. Bioethanol is by far the most common biofuel in use worldwide. Lignocellulosic biomass is the most promising renewable resource for fuel bioethanol production. Bioconversion of lignocellulosics to ethanol consists of four major unit operations: pretreatment, ...
Pluim Dick - - 2013
Pharmacodynamic (PD) analysis requires accurate and precise quantification of enzyme activity targeted by anticancer agents in surrogate cells like peripheral blood mononuclear cells (PBMCs). Enzyme activity is normally reported per mass unit of protein input. However, high and fluctuating hemoglobin (Hb) contamination strongly influences the protein content of PBMC cytosolic ...
Giles L C - - 2013
Objective:Rapid growth, possibly occurring in critical periods in early life, may be important for the development of obesity. It is unknown whether this is influenced by postnatal exposures such as age-relevant sources of stress. Frequent house moves may be one such stressor. We aimed to examine if there is a ...
Jerger James - - 2013
Two quite sensible ways of recording audiometric threshold data emerged in the early 1920s. They were advanced by Edmund Prince Fowler, an otologist, and by Harvey Fletcher, a physicist. Either would probably have been better than the present system, and would have preserved scientific tradition relative to the orientation of ...
Pihlajamaa Tero - - 2013
Thrombospondin-related anonymous protein (TRAP), localized in the micronemes and on the surface of sporozoites of infamous malaria parasite Plasmodium, is a key molecule upon infection of mammalian host hepatocytes and invasion of mosquito salivary glands. TRAP contains two adhesive domains responsible for host cell recognition and invasion, and is known ...
Jones Natalie - - 2013
PTEN plays a well-established role in the negative regulation of the PI3K pathway which is frequently activated in several cancer types, including breast cancer. A nuclear function in the maintenance of chromosomal stability has been proposed for PTEN but is yet to be clearly defined. In order to improve understanding ...
Tomfohr Lianne M - - 2013
The current study investigated the factor structure of the Pittsburgh Sleep Quality Index (PSQI) among English speaking non-Hispanic whites (NHW) and English and Spanish speaking Hispanics of Mexican descent (HMD). The PSQI was administered during a telephone interview. In order to test the factor structure of the PSQI structure across ...
Klaas James P JP Mayo Clinic, Rochester, MN, - - 2013
To review descriptions of paroxysmal dysarthria and ataxia in multiple sclerosis (MS), with special attention given to Parker and his 1946 case series. Evaluation of original publications describing paroxysmal dysarthria and ataxia, bibliographic information, writings, and unpublished letters from the Mayo Clinic Historical Unit. In 1940, Störring described a patient ...
Eisenberg D P - - 2013
A Val(66)Met single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured hippocampal neurons and predicts impaired memory and exaggerated basal hippocampal activity in healthy humans. Several clinical genetic association studies along with multi-modal evidence for hippocampal dysfunction in schizophrenia indirectly suggest a relationship ...
Bozóky Benedek - - 2013
Increasing evidence indicates the importance of the tumor microenvironment, in particular cancer associated fibroblasts, in cancer development and progression. In this study we developed a novel, visually based method to identify new immunohistochemical signatures of these fibroblasts. The method employed a protein list based on 759 protein products of genes ...
Vasquez N - - 2013
Study design:Retrospective review.Objectives:The International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) assesses cutaneous sensibility through light touch (LT) and sharp-dull discrimination, referred to as pin prick (PP). This project aimed to confirm a tendency for LT to score higher than PP in SCI subjects and discuss possible reasons ...
Hoque Romy - - 2013
Excessive fragmentary myoclonus (EFM) consists of brief, asynchronous, twitch-like movements appearing asymmetrically in sleep. The new AASM Manual for the Scoring of Sleep and Associated Events identifies some EFM scoring criteria but does not provide amplitude criteria for scoring EFM. Older observational series have used 50 μVs. We report data ...
Kuhla Angela - - 2013
Aging often restricts the capacity of the immune system. Endotoxemia is characterized by an immune response initiated by a group of pattern recognition receptors including the receptor for advanced glycation end products (RAGE). The aim of this study was to clarify to which extent RAGE and its signaling pathways such ...
Yang Ian A - - 2013
Asthma and COPD continue to have considerable impact on disease burden and mortality world-wide. Early diagnosis still remains a challenge, with low uptake of spirometry in many countries. Implementing best practice management for airways disease is a critical goal for health care systems - the management now includes pharmacological and ...
Sorelle J A - - 2013
AIMS/HYPOTHESIS: Beta cell death triggered by pro-inflammatory cytokines plays a central role in the pathogenesis of type 1 diabetes and loss of transplanted islets. The nuclear factor κB (NF-κB) signalling pathway is a key regulator of beta cell stress response, survival and apoptosis. Withaferin A (WA), a steroidal lactone derived ...
Wu Tzy-Haw - - 2013
ABSTRACT: BACKGROUND: Evidence about whether white blood cell (WBC) or its subtypes can act as a biomarker to predict the ischemic stroke events in the general population is scanty, particularly in Asian populations. The aim of this study is to establish the predictive ability of total WBC count or subtypes ...
Völzke Henry - - 2013
Objectives Studies on the potential association of socioeconomic status with iodine supply and the risk for thyroid disorders from developed countries are sparse. Socioeconomic status, however, may particularly impact the efficiency of iodine prophylaxis programs, which are based on the voluntary principle. This study aims to investigate whether the socioeconomic ...
Kern Lisa M - - 2013
The federal Electronic Health Record Incentive Program requires electronic reporting of quality from electronic health records, beginning in 2014. Whether electronic reports of quality are accurate is unclear. To measure the accuracy of electronic reporting compared with manual review. Cross-sectional study. A federally qualified health center with a commercially available ...
Sawanyawisuth Kittisak - - 2013
To investigate the prevalence and predictors of RLS in Hispanics of Mexican descent (HMD) and non-Hispanic whites (NHW). A population-based random digit dialing telephone questionnaire. San Diego County California 1,754 HMD and 1,913 NHW adults ≥ 18 years of age able to participate in a telephone interview in English or ...
El-Sitt Sally - - 2013
Abstract RhoGTPases are defined as a family of 20 small G proteins playing important roles in almost every cellular process. RhoGTPases are guanine nucleotide-binding proteins existing in two forms: the active form which is GTP bound and the inactive one that being GDP bound. RhoGTPase-activating proteins known as RhoGAPs constitute ...
Barsoumian Alice - - 2013
Background: Acinetobacter baumannii-calcoaceticus complex (ABC) isolates are often multidrug-resistant, including to carbapenems. Chromogenic media can facilitate the rapid detection of Gram-negative bacteria, often with the addition of supplements to a base chromogenic medium to detect resistance. We examined various combinations of available media to detect imipenem resistance among 107 ABC ...
Erbek S - - 2013
Objective: Proteases of the disintegrin and metalloproteinase family (also known as ADAM proteins) are involved in various physiological and pathological processes. This study assessed the expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma. Materials and methods: The study evaluated cholesteatoma specimens from 19 patients, and ...
Jiang Rongrong - - 2013
The present study investigated the inhibitory effect of cannabidiol (CBD), a major constituent of marijuana, on the catalytic activity of cytochrome P450 2C19 (CYP2C19). (S)-Mephenytoin 4'-hydroxylase activities of human liver microsomes (HLMs) and recombinant CYP2C19 were inhibited by CBD in a concentration-dependent manner (IC(50) = 8.70 and 2.51 µM, respectively). ...
Uto-Kondo Harumi - - 2013
Endothelium-bound extracellular superoxide dismutase (eEC-SOD), a major antioxidative enzyme in the vasculature, is involved in anti-atherogenesis by inhibiting low-density lipoprotein (LDL) oxidation. The objective was to investigate whether the polyphenol-rich juar tea had beneficial effects on LDL oxidation and eEC-SOD levels in patients with metabolic syndrome (MetS). A total of ...
Boormans1 Joost L - - 2013
Molecular classification of ERG-rearranged prostate cancer clarifies the role of TMPRSS2-ERG in the development and progression of prostate cancer. The objective of the present study was to identify direct ERG target genes in ERG-rearranged prostate cancer. Two independent cohorts of primary prostate cancer (cohort A, n=48; cohort B, n=31), a ...
Otte Rik J RJ Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The - - 2013
Several studies have attributed deterioration of sound localization in the horizontal (azimuth) and vertical (elevation) planes to an age-related decline in binaural processing and high-frequency hearing loss (HFHL). The latter might underlie decreased elevation performance of older adults. However, as the pinnae keep growing throughout life, we hypothesized that larger ...
Vian Izabele - - 2013
Previous studies have shown that maternal consumption of polyphenol-rich foods after the third trimester of pregnancy may interfere with the anatomical and functional activity of the fetal heart as, to our knowledge, there are no validated instruments to quantify total polyphenols in pregnant women. The aim of this study was ...
Sinclair Kenneth - - 2013
Mesenchymal stem cells (MSC) are a population of tissue resident adult progenitor cells which were originally identified in bone marrow, but have now been identified in many organs including the lung. Although their precise role in organ function remains incompletely defined, mounting evidence suggests that they are an important component ...
Pavlovic Aleksandra M AM Neurology Clinic, Faculty of Medicine, University of Belgrade, Dr Subotica 6, 11000, Belgrade, Serbia. - - 2013
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common heritable cause of stroke and vascular dementia in adults. We present a family from Serbia presenting with stroke and depression in the lack of vascular risk factors, with brain MRI indicating CADASIL. A novel NOTCH3 Gly89Cys ...
Williams Calvin B CB Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. - - 2013
The transcription factor Foxp3 plays an indispensible role in the differentiation of regulatory T (Treg) cells and the expression of their suppressive functions. In a recent article published in Nature, Ouyang et al. demonstrate that Treg cell differentiation is also enabled by transcriptional networks controlled by another Forkhead box family ...
Hagely Katherine B - - 2013
Soybeans are an important source of protein-rich meal for livestock feed formulations. Recent changes in the cost of commodity-based sources of metabolizable energy (ME) inputs has put pressure on soybean meal to deliver both protein and ME in feed formulations. The non-oil fraction of soybean contains approximately 12% soluble carbohydrates, ...
Cormie P - - 2013
Background:Previous research has shown exercise to be an effective method to mitigate many adverse treatment-related effects of androgen suppression therapy (AST) but the potential impact of exercise on sexual activity remains unknown. The purpose of this investigation was to report the effect of a 12-week exercise program on sexual activity ...
Abboudi Hamid H Royal Sussex County Hospital, Easter Road, Brighton BN2 5BE, - - 2013
Although ureteric injury is relatively uncommon, it is a serious event that can result in intra-abdominal sepsis, renal failure, and loss of the ipsilateral renal unit. Most injuries are iatrogenic and remain undiagnosed until the patient presents with symptoms postoperatively. In addition to compromising patient safety, missed ureteric injuries frequently ...
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