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Results 201 - 250 of 2923
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Short Matthew W - - 2013
Iron deficiency is the most common nutritional disorder worldwide and accounts for approximately one-half of anemia cases. The diagnosis of iron deficiency anemia is confirmed by the findings of low iron stores and a hemoglobin level two standard deviations below normal. Women should be screened during pregnancy, and children screened ...
Liu Jun - - 2013
Quantification of the association between the intake of fruit and vegetables and risk of esophageal squamous cell carcinoma (ESCC) is controversial even though several studies have explored this association. We summarized the evidence from observational studies in categorical, linear, and non-linear dose-response meta-analyses. Eligible studies published up to 31 July ...
O'Halloran Philip J - - 2013
INTRODUCTION: Although uncommon, there is significant morbidity and mortality associated with paediatric spinal glioblastoma. The paucity of cases makes treatment options difficult. The current recommended standard of care is biopsy followed by adjuvant chemo-radiotherapy, with emerging data supporting the role of safe gross total resection. OBJECTIVE: The purpose of this ...
Pereira Guillermo - - 2013
The high cost and restricted availability of black truffle spore inoculum for controlled mycorrhiza formation of host trees produced for truffle orchards worldwide encourage the search for more efficient and sustainable inoculation methods that can be applied globally. In this study, we evaluated the potential of the nurse plant method ...
Banan Mehdi - - 2013
Hydroxyurea (HU) is a drug that induces fetal hemoglobin production. As a result, HU is widely used to treat β-thalassemia (β-thal) patients. However, the response of these patients to HU varies. Some β-thal patients respond favorably to treatment while others do not respond at all. HU has a number of ...
Chen Baowei - - 2013
Arsenic trioxide has been successfully used as a therapeutic in the treatment of acute promyelocytic leukemia (APL). Detailed monitoring of the therapeutic arsenic and its metabolites in various accessible specimens of APL patients can contribute to improving treatment efficacy and minimizing arsenic-induced side effects. This article focuses on the determination ...
Sabounchi N S - - 2013
Basal metabolic rate (BMR) represents the largest component of total energy expenditure and is a major contributor to energy balance. Therefore, accurately estimating BMR is critical for developing rigorous obesity prevention and control strategies. Over the past several decades, numerous BMR formulas have been developed targeted to different population groups. ...
Nelen Stijn D - - 2013
To predict prognosis of gastric cancer, an adequate assessment of the stage of gastric cancer is important. The UICC/AJCC TNM classification is the most commonly used classification system. For adequate N staging at least 15 lymph nodes should be retrieved. In some countries, this amount of lymph nodes is not ...
Lang Chim C - - 2013
The renin-angiotensin-aldosterone system is a well-established therapeutic target in the treatment of heart failure (HF). Substantial advances have been made with existing agents-angiotensin-converting enzyme (ACE) inhibitors, angiotensin II-receptor blockers (ARBs), and mineralocorticoid-receptor antagonists (MRAs)-and new data continue to emerge. The indication for the use of MRAs has been broadened to ...
Spelzini Federico - - 2013
INTRODUCTION AND HYPOTHESIS: The aim of this study was to evaluate the functional outcome of a single-incision sling procedure for the treatment of female stress urinary incontinence (SUI) and to correlate the cure rate with a pelvic floor ultrasound examination METHODS: Fifty-seven patients treated with a single-incision sling procedure between ...
Mohammadi Morteza - - 2013
In this work, the two mixtures of ionic liquid 1-n-propyl-4-amino-1,2,4-triazolium bromide and each type of the aggregated single-walled carbon nanotubes (SWCNTs), i.e. bundled SWCNTs and non-bundled, were investigated using molecular dynamics (MD) simulations. The structural characteristics of a SWCNT in the ionic liquid (IL) were examined by analyzing the radial ...
Wu R Y - - 2013
Background  Commensal bacteria such as probiotics that are neuroactive acutely affect the amplitudes of intestinal migrating motor complexes (MMCs). What is lacking for an improved understanding of these motility effects are region specific measurements of velocity and frequency. We have combined intraluminal pressure recordings with spatiotemporal diameter maps to analyze ...
Rice Todd W - - 2013
QUESTION Is moderate or severe hypoglycemia associated with increased risk for mortality in critically ill adults? METHODS DESIGN Post hoc analysis of a randomized controlled trial (Normoglycemia in Intensive Care Evaluation-Survival Using Glucose Algorithm Regulation [NICE-SUGAR] trial). ClinicalTrials.gov NCT00220987. ALLOCATION {Concealed}*.† BLINDING {Unblinded}*†. FOLLOW-UP PERIOD 90 days. SETTING 42 hospital ...
Sagliocca Luciano - - 2013
BACKGROUND: Systematic reviews (SR) of clinical evidence are rightfully considered the basis for developing recommendations to support decisions in current practice. To avoid bias, SRs are expected to be systematic in their research strategy and are exhaustive. The drawback of the latter criteria relies in the substantial work needed to ...
Su Chean-Cheng - - 2013
The oppositely oriented lamellae in ridge and valley bands of ring-banded spherulites in biodegradable poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) interacting with amorphous poly(vinyl acetate) (PVAc) were examined using polarized-light optical, scanning electron, and atomic-force microscopy techniques (POM, SEM, AFM). Solvent-etching and fracturing were utilized for probing the interior morphology of the ...
Spagnuolo P A - - 2013
Parthenolide is selectively toxic to leukemia cells; however, it also activates cell protective responses which may limit its clinical application. Therefore, we sought to identify agents that synergistically enhance parthenolide's cytotoxicity. Using a high-throughput combination drug screen, we identified the hypoglycemic, vildagliptin, which synergized with parthenolide to induce death of ...
Dumitrascu Traian - - 2013
INTRODUCTION: Resection for hilar cholangiocarcinoma is the single hope for long-term survival. METHODS: Ninety patients underwent curative intent surgery for hilar cholangiocarcinoma between 1996 and 2012. The potential prognostic factors were assessed by univariate (Kaplan-Meier curves and log-rank test) and multivariate analyses (Cox proportional hazards model). RESULTS: The median overall ...
Kamerlin Shina C L - - 2013
Phosphoryl transfer plays key roles in signaling, energy transduction, protein synthesis, and maintaining the integrity of the genetic material. On the surface, it would appear to be a simple nucleophile displacement reaction. However, this simplicity is deceptive, as, even in aqueous solution, the low-lying d-orbitals on the phosphorus atom allow ...
Mumtaz Zubia - - 2013
ABSTRACT: While infertility is a global challenge for millions of couples, low income countries have particularly high rates, of up to 30%. Infertility in these contexts is not limited to its clinical definition but is a socially constructed notion with varying definitions. In highly pronatalistic and patriarchal societies like Pakistan, ...
Li Jun-Nan - - 2013
ABSTRACT: BACKGROUND: Wireless esophageal pH monitoring system is an important approach for diagnosis of gastroesophageal reflux disease (GERD), the aim of this study is to test the tolerability and utility of the first wireless esophageal pH monitoring system made in China, and evaluate whether it is feasible for clinical application ...
Shaheen Nicholas J - - 2013
OBJECTIVES:Approximately 20-30% of patients with gastroesophageal reflux disease (GERD) do not experience complete symptom resolution during proton pump inhibitor (PPI) therapy. The aim of this study was to determine the prevalence of esophageal mucosal breaks among patients who have a partial response to PPI therapy.METHODS:This was an analysis of data ...
Rajan Roopa - - 2013
A 27-year-old man, recent visitor to the Middle East, presented with 6-week history of fever (up to 102°F) followed by altered behavior and left hemiparesis. CSF was acellular with raised protein (138 mg/dL). CSF bacterial culture was sterile; adenosine deaminase normal (3 U/L); cryptococcal antigen, Venereal Disease Research Laboratory test, ...
Binauld Sandra - - 2013
Polymers that start degrading under acidic conditions are increasingly investigated as a pathway to trigger the release of drugs once the drug carrier reached the slightly acidic tumour environment or after the drug carrier has been taken up by cells, resulting in the localization of the polymer in the acidic ...
Nascimento Cássio do - - 2013
OBJECTIVES: The aim of this in vivo study was to evaluate the efficacy of three antimicrobial solutions on the disinfection of toothbrushes after storage in closed containers. MATERIALS AND METHODS: Sixteen healthy subjects were enroled in this randomized cross-over clinical investigation. The study was conducted in four phases, in which ...
Perrelli Maria-Giulia - - 2013
Catestatin (CST) limits myocardial ischaemia/reperfusion (I/R) injury with unknown mechanisms. Clearly phosphoinositide-3-kinase (PI3K), protein kinase C (PKC) isoforms, including intra-mitochondrial PKCε, mitochondrial K(ATP) (mitoK(ATP)) channels and subsequent reactive oxygen species (ROS)-signalling play important roles in postconditioning cardioprotection, preventing mitochondrial permeability transition pore (mPTP) opening. Therefore, we studied the role of ...
Ensaff Hannah - - 2013
OBJECTIVE: To examine students' school food choice in relation to school food standards and entitlement to free school meals (FSM). DESIGN: Cross-sectional analysis of students' school food choices. SETTING: Two large secondary schools in Yorkshire, England. SUBJECTS: Students (n 2660) aged 11-18 years. RESULTS: Sandwiches and pizza were the most ...
Shiokawa Masahiro - - 2013
OBJECTIVES:Although simultaneous occurrences of autoimmune pancreatitis (AIP) and cancer are occasionally observed, it remains largely unknown whether cancer and AIP occur independently or these disorders are interrelated. The aim of this study was to examine the relationship between AIP and cancer.METHODS:We conducted a multicenter, retrospective cohort study. One hundred and ...
Galal Ahmed - - 2013
Background. Wide-necked and non-saccular aneurysms are difficult to treat with coil embolization. The use of stents has expanded the role of endovascular treatment. Methods. A retrospective study of 43 patients with wide-necked, fusiform or blister aneurysms treated with stent-assisted coiling or stent alone. The review of medical files and images ...
Ye Xiao-Juan - - 2013
A balance between the hydrogen capacity and reversibility is a big challenge in the search for hydrogen storage materials. Using van der Waals-corrected density functional theory, we perform a detailed study of the hydrogen molecules adsorption on lithium (Li) decorated zero- and two-dimensional boron-carbon (B-C) compounds. It is found that ...
Hirsch Calvin - - 2013
QUESTION In elderly patients who report memory complaints to their primary care physicians, does ginkgo biloba extract reduce risk for Alzheimer disease (AD)? METHODS DESIGN Randomized placebo-controlled trial (GuidAge). ClinicalTrials.gov NCT00276510. ALLOCATION Concealed.* BLINDING Blinded* (patients, clinicians, and dementia adjudication committee). FOLLOW-UP PERIOD Median 5 years. Follow-up after 2 years ...
Blevins Erin - - 2013
Studies of aquatic locomotion typically assume that organisms move through unbounded fluid. However, benthic fishes swim close to the substrate and will experience significant ground effects, which will be greatest for fishes with wide spans such as benthic batoids and flatfishes. Ground effects on fixed-wing flight are well understood, but ...
Allena Rachele - - 2013
Cell migration triggered by pseudopodia (or "false feet") is the most used method of locomotion. A 3D finite element model of a cell migrating over a 2D substrate is proposed, with a particular focus on the mechanical aspects of the biological phenomenon. The decomposition of the deformation gradient is used to ...
Kim Eui Hyun - - 2013
BACKGROUND: Intraoperative magnetic resonance imaging (iMRI) is proven to be advantageous in transsphenoidal surgery (TSS) for pituitary adenomas. We evaluated the efficacy of low-field iMRI. Also, we described several techniques to enhance the visibility of the tumor resection margin. METHODS: Two hundred twenty-nine patients who underwent TSS using low-field iMRI ...
Soda Kosuke - - 2013
Widespread outbreaks of highly pathogenic avian influenza (HPAI) caused by H5N1 viruses occurred in wild birds in Japan from 2010-11. Forty out of sixty-three deceased wild birds belonged to the order Anseriformes, and mandarin duck was one of the dominant species. To estimate the risk of mandarin ducks as a ...
Zhang Xiaoyue - - 2013
The mechanical characteristics of human red blood cell (RBC) membrane change due to C(60) nanoparticle (NP) infiltration have been investigated in the present work. Using experimental approaches, including optical tweezer (OT) stretching and atomic force microscopy (AFM) indentation, we found that RBCs in the presence of C(60) NPs are softer ...
Van Spall Harriette G C - - 2013
QUESTION What is the effectiveness of clinical service interventions in patients previously hospitalized for heart failure (HF)? REVIEW SCOPE Included studies had ≥ 6 months of follow-up and compared clinical service interventions with usual care in patients ≥ 18 years of age who had ≥ 1 previous secondary care admission with HF. Clinical ...
Matsumoto Shuzo - - 2013
The structural feature of unfolding intermediate of pokeweed anti-viral protein (PAP) was characterized using time-resolved fluorescence spectroscopic methods to elucidate protein folding/unfolding process. CD and fluorescence spectra consistently demonstrated that the unfolding of PAP completed at 4 M of guanidine hydrochloride (GuHCl). The fluorescence resonance energy transfer (FRET) and time-resolve fluorescence ...
Rishi Praveen - - 2013
Abstract Emerging drug resistance has forced the scientific community to revisit the observational data documented in the folklore and come up with novel and effective alternatives. Candidates from eukaryotic origin including herbal products and antimicrobial peptides are finding a strategic place in the therapeutic armamentarium against infectious diseases. These agents ...
Dale Gillian - - 2013
When the second of two targets (T2) is presented in close temporal proximity (within 200-500 ms) to the first (T1), the accuracy for reporting T2 is reduced relative to when the targets are separated by longer durations; this effect is known as the attentional blink (AB). Two recent studies have shown ...
Gilgunn Sarah - - 2013
Prostate cancer-the most commonly diagnosed cancer in men worldwide-can have a substantial effect on quality of life, regardless of the route the cancer takes. The serum PSA assay is the current gold standard option for diagnosing prostate cancer. However, a growing body of evidence suggests that PSA screening for prostate ...
Feng Ningdong - - 2013
The origin of the exceptionally high activity of (B, Ag)-codoped TiO2 catalysts under solar-light irradiation has been investigated by XPS and 11B solid-state NMR spectroscopy in conjunction with density functional theory (DFT) calculations. XPS experimental results demonstrated that a portion of the dopant Ag (Ag3+) ions were implanted into the ...
Fu Haoliang - - 2013
The use of multiple-center intramolecular H-bonds for the efficient construction of macrocycles of varying structures and functions is among the newest and the most noteworthy additions to the toolbox for macrocycle synthesis. This strategy has allowed the creation of sizable interior cavities as small as 2.8 Å and as large ...
Magalhães Pedro - - 2013
Pulse wave velocity (PWV) is an independent predictor of cardiovascular (CV) risk. Higher PWV values have been observed in Africans; however, there are no established age- and gender-adjusted reference values for this population. Therefore, PWV was measured using a validated device (Complior SP) in 544 subjects recruited from an occupational ...
Idota Yoko - - 2013
Alginate (ALA), which is an intercellular polysaccharide associated with brown algae, is used as a food additive, a health food and a medicine. Here, we first examined the adsorption of strontium (Sr) and cesium (Cs) by ALA in vitro, and then evaluated the effects of ALA on absorption and excretion ...
Dalal Shalini - - 2013
Access to pain relief is a crucial concern for patients with cancer, and remains so at all stages of the illness trajectory. This Review covers the scope of the problem and considers the optimal palliative strategy, mainly through the use of opioids. It also discusses various barriers to effective pain ...
Rao Nithya - - 2013
The metalloproteinase ADAMTS4/aggrecanase-1 is highly expressed in cartilage and has been implicated in human arthritis. Although abundantly expressed in many types of cancer, its role in cancer remains unknown. In this work, we demonstrate for the first time that full-length ADAMTS4 or its catalytically more active N-terminal 53 kDa autocatalytic ...
Gianicolo Emilio Antonio Luca - - 2013
Exposure to air pollutants has been associated with increased hospital admissions (HAs) for respiratory and cardiovascular diseases. This work describes a short-term epidemiological study in Brindisi, a highly industrialized town in Southern Italy. The effects of daily exposure to PM(10) and NO(2) on daily HAs for cardiac, respiratory, and cerebrovascular ...
Majumder Kaustav - - 2013
Egg protein ovotransferrin-derived peptides (IRW and IQW) can attenuate tumor necrosis factor (TNF)-induced inflammatory responses and oxidative stress in endothelial cells. The present study investigates the structural requirements and the molecular mechanisms underlying these events. While IRW significantly inhibited TNF-induced up-regulation of intercellular cell adhesion molecule-I (ICAM-1) and vascular cell ...
Watson Melanie - - 2013
BACKGROUND: The economic costs of maternal obesity and underweight have not been described. We aim to assess the effect of maternal underweight and obesity on hospital utilisation and hospital costs. METHODS: Data from the Queensland Perinatal Data Collection and Queensland Hospital Admitted Patient Data Collection were analysed for 2008. The ...
Tonolini Massimo - - 2013
The spleen is commonly involved in a wide spectrum of hematologic, immunologic, neoplastic, infectious, and vascular systemic disorders. Sometimes overlooked on imaging studies outside the trauma setting, the spleen may harbor severe infections, and occasionally undergoes spontaneous bleeding or rupture. This pictorial essay reviews common and unusual causes of nontraumatic ...
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