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Rice Todd W - - 2013
QUESTION Is moderate or severe hypoglycemia associated with increased risk for mortality in critically ill adults? METHODS DESIGN Post hoc analysis of a randomized controlled trial (Normoglycemia in Intensive Care Evaluation-Survival Using Glucose Algorithm Regulation [NICE-SUGAR] trial). ClinicalTrials.gov NCT00220987. ALLOCATION {Concealed}*.† BLINDING {Unblinded}*†. FOLLOW-UP PERIOD 90 days. SETTING 42 hospital ...
Wiens Miriam E - - 2013
Family communication of genetic risk information is a complex process. Currently, there are no evidence-based interventions to help genetics professionals facilitate the process of disclosure within families. This study was designed to create a framework to assist in the development of tools to support patients in communicating genetic risk information ...
Goutelle Sylvain S Service Pharmaceutique, Groupement Hospitalier de Gériatrie, Hospices Civils de Lyon, Lyon, France. - - 2013
We present a unified quantitative approach to predict the in vivo alteration in drug exposure caused by either cytochrome P450 (CYP) gene polymorphisms or CYP-mediated drug-drug interactions (DDI). An application to drugs metabolized by CYP2C19 is presented. The metrics used is the ratio of altered drug area under the curve ...
Sagliocca Luciano - - 2013
BACKGROUND: Systematic reviews (SR) of clinical evidence are rightfully considered the basis for developing recommendations to support decisions in current practice. To avoid bias, SRs are expected to be systematic in their research strategy and are exhaustive. The drawback of the latter criteria relies in the substantial work needed to ...
Su Chean-Cheng - - 2013
The oppositely oriented lamellae in ridge and valley bands of ring-banded spherulites in biodegradable poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) interacting with amorphous poly(vinyl acetate) (PVAc) were examined using polarized-light optical, scanning electron, and atomic-force microscopy techniques (POM, SEM, AFM). Solvent-etching and fracturing were utilized for probing the interior morphology of the ...
Rosenblat Mira - - 2013
Abstract In the current study, we analyzed free radicals scavenging activity of monocytes-macrophages in the absence or presence of antioxidants such as polyphenols or paraoxonase 1 (PON1). THP-1 human monocytic cell line, murine J774A.1 macrophages, as well as human primary monocytes have the capability to scavenge free radicals, as measured ...
Guan Shan - - 2013
Abstract Aim: The purpose of this study was to investigate the detailed mechanisms of oral absorption enhancement of bergenin (BN) using BN-phospholipid complex (BPC). Methods: Multiple models such as ex vivo everted rat gut sac model and in vitro Caco-2 cell model were used. Meanwhile, the effect of chitosan on ...
Houyel Lucile - - 2013
Outflow tract defects, including cardiac neural crest defects (so-called conotruncal defects) and transposition of the great arteries, are due to an abnormal rotation of the outflow tract during cardiac development. Coronary orifices are often abnormal in outflow tract defects, particularly in common arterial trunk (CAT). A recent study indicates that ...
Sun Chuandi C Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People's Republic of - - 2013
To investigate the possibility of liquid proliposomes being carriers for oral delivery, nimodipine liquid proliposomes-based soft capsules (NPSC) were prepared. Nimodipine proliposomes were characterized by transmission electron microscopy (TEM), conversion rate from proliposomes to liposomes, entrapment efficiency, particle size, and zeta potential. Accelerated stability testing of NPSC was carried out ...
Grigorian Melina M Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, - - 2013
Hemocytes (blood cells) are motile cells that move throughout the extracellular space and that exist in all clades of the animal kingdom. Hemocytes play an important role in shaping the extracellular environment and in the immune response. Developmentally, hemocytes are closely related to the epithelial cells lining the vascular system ...
Wang Jing-Houng - - 2013
To compare the efficacy of hepatocellular carcinoma (HCC) surveillance at 4- and 12-month intervals in a community for patients with chronic viral hepatitis and thrombocytopenia. In 10 townships, adults (≥ 40 years) with platelet ≤ 150 (× 10(9))/l, positive hepatitis B surface antigen, or antibody to hepatitis C virus were ...
Tonolini Massimo - - 2013
The spleen is commonly involved in a wide spectrum of hematologic, immunologic, neoplastic, infectious, and vascular systemic disorders. Sometimes overlooked on imaging studies outside the trauma setting, the spleen may harbor severe infections, and occasionally undergoes spontaneous bleeding or rupture. This pictorial essay reviews common and unusual causes of nontraumatic ...
Solovchenko Alexei - - 2013
We investigated the feasibility of rapid, nondestructive assay of carotenoid-to-chlorophyll (Car/Chl) ratio and total carotenoids (Car) in cell suspensions of the carotenogenic chlorophyte Haematococcus pluvialis Flotow under stressful conditions. Whole-cell spectra are characterized by variable nonlinear contributions of Car and chlorophylls (Chl), with a strong influence of Car packaging and ...
Kandziora-Ciupa Marta - - 2013
The purpose of this study was to explore a possible relationship between the availability of metals in soil (Cd, Fe, Mn, Pb and Zn) and their concentrations in leaves of Vaccinium myrtillus L. as a species which has been reported to be a successful colonist of acid-and-heavy metal-contaminated soil. Analysis ...
Xiao Zhi-Yan - - 2013
Bilirubin (BR) aggregating at liquid/liquid interface was firstly detected by Fourier transform infrared (FTIR) imaging/spectroscopy combining with ultraviolet-visible (UV/Vis) absorption spectra. In the UV/Vis absorption spectra of BR aggregate, a new shoulder appeared at 474 nm, and BR absorption maximum underwent red shift from 450 nm to a longer wavelength at 497 nm, ...
Hong T K - - 2013
Objective:The aim of this study was to examine changes over 5 years in body mass index (BMI) and waist circumference (WC) of adolescents from Ho Chi Minh City by age, gender and household economic status.Methods:Anthropometry including height, weight and WC measurements of 759 secondary high school students were collected 1-year ...
Haering Christian H CH European Molecular Biology Laboratory, Heidelberg, Germany. - - 2013
The 106th Boehringer Ingelheim Fonds International Titisee Conference, 'Reconstituting Chromatin: From Self-assembly to Self-organization', took place in October 2012. The organizers, Andrea Musacchio and Tom Muir, brought together biologists, chemists and physicists to discuss the principles of chromosome assembly and organization. Topics of discussion ranged from new insights gained from ...
Ou Daxin - - 2013
A new 6-benzylaminopurine-functionalized disubstituted polyacetylene (P2) with strong green fluorescence is successfully synthesized by utilizing the postfunctional method. The polymer is soluble in common organic solvents, and its strong green fluorescence can be quenched by copper and cobalt ions with a detection limit down to 1.0 × 10(-8) (0.64 ppb) ...
Lim Lionel S - - 2013
QUESTION What are the benefits and harms of general health checks in adults in primary care or community settings? REVIEW SCOPE Included studies compared general health checks (screening for > 1 disease or risk factor in > 1 organ system) with no health checks in adults in primary care or community settings. ...
Schrager Sarina - - 2013
Endometriosis, which affects up to 10 percent of reproductive-aged women, is the presence of endometrial tissue outside of the uterine cavity. It is more common in women with pelvic pain or infertility (25 to 40 percent and 70 to 90 percent, respectively). Some women with endometriosis are asymptomatic, whereas others ...
Rosenberg Richard S - - 2013
The program provides a unique opportunity to compare a large number of scorers with varied levels of experience to determine sleep stage scoring agreement. The objective is to examine areas of disagreement to inform future revisions of the AASM Manual for the Scoring of Sleep and Associated Events. The sample ...
Ba┼čak Esra - - 2013
Bovine liver catalase was covalently immobilized onto amino acid-modified chitosan beads. The beads were characterized with SEM, FTIR, TGA and the effects of immobilization on optimum pH and temperature, thermostability, reusability were evaluated. Immobilized catalase showed the maximal enzyme activity at pH 7.0 at 30°C. The kinetic parameters, K(m) and ...
Klotz Laurence - - 2013
OPINION STATEMENT: Low-risk prostate cancer: How I would treat it?Overtreatment of many conditions diagnosed by screening has become increasingly recognized as a contemporary malady associated with modern medicine's efforts at earlier detection. The diagnosis of low-grade prostate cancer clearly qualifies as an example of potential overdiagnosis and overtreatment. Active surveillance ...
Polanski J F - - 2013
Objective: There are many well-known aetiological mechanisms of presbyacusis, and free radicals have been shown to play an important role. This study aimed to evaluate the effect of antioxidant agents on the hearing threshold of patients with presbyacusis. Methods: One hundred and twenty individuals were divided into four groups and ...
Povarnitsyn Mikhail E - - 2013
Laser ablation in liquids is now commonly used to produce colloidal nanoparticles (NPs) that have found numerous applications in different areas. In experiments, NPs of different materials can be rather easily obtained by using laser systems with various pulse durations, shapes, wavelengths, and fluences. In this paper, we focus our ...
Jacques Paul F PF Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA. - - 2013
Evidence for cardioprotective effects of lycopene is inconsistent. Studies of circulating lycopene generally report inverse associations with CVD risk, but studies based on lycopene intake do not. The failure of dietary studies to support the findings based on biomarkers may be due in part to misclassification of lycopene intakes. To ...
Sherf Dagan Shiri - - 2013
ABSTRACT: OBJECTIVE: Body mass index (BMI) is more commonly used than waist circumference as a measure of adiposity in clinical and research settings. The purpose of this study was to compare the associations of BMI and waist circumference with cardiorespiratory fitness. METHODS: In a cross-sectional study of 403 healthy men ...
Rubenstein Joel H JH Center for Clinical Management Research, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan 48109, USA. - - 2013
Risk factors for Barrett's esophagus include gastroesophageal reflux disease (GERD) symptoms, age, abdominal obesity, and tobacco use. We aimed to develop a tool using these factors to predict the presence of Barrett's esophagus. Male colorectal cancer (CRC) screenees were recruited to undergo upper endoscopy, identifying newly diagnosed cases of Barrett's ...
Karlström A A Department of Health Science, Mid Sweden University, Holmgatan 10, Sundsvall, Sweden. - - 2013
To compare maternal complications and infant outcomes for women undergoing elective caesarean sections based on a maternal request and without recorded medical indication with those of women who underwent spontaneous onset of labour with the intention to have a vaginal birth. Retrospective register study. Sweden; Medical Birth Register used for ...
Short Matthew W - - 2013
Iron deficiency is the most common nutritional disorder worldwide and accounts for approximately one-half of anemia cases. The diagnosis of iron deficiency anemia is confirmed by the findings of low iron stores and a hemoglobin level two standard deviations below normal. Women should be screened during pregnancy, and children screened ...
St-Onge Marie-Pierre - - 2013
Short sleep duration and obesity are common occurrence in today's society. An extensive literature from cross-sectional and longitudinal epidemiological studies shows a relationship between short sleep and prevalence of obesity and weight gain. However, causality cannot be inferred from such studies. Clinical intervention studies have examined whether reducing sleep in ...
Liu Jun - - 2013
Quantification of the association between the intake of fruit and vegetables and risk of esophageal squamous cell carcinoma (ESCC) is controversial even though several studies have explored this association. We summarized the evidence from observational studies in categorical, linear, and non-linear dose-response meta-analyses. Eligible studies published up to 31 July ...
O'Halloran Philip J - - 2013
INTRODUCTION: Although uncommon, there is significant morbidity and mortality associated with paediatric spinal glioblastoma. The paucity of cases makes treatment options difficult. The current recommended standard of care is biopsy followed by adjuvant chemo-radiotherapy, with emerging data supporting the role of safe gross total resection. OBJECTIVE: The purpose of this ...
Pereira Guillermo - - 2013
The high cost and restricted availability of black truffle spore inoculum for controlled mycorrhiza formation of host trees produced for truffle orchards worldwide encourage the search for more efficient and sustainable inoculation methods that can be applied globally. In this study, we evaluated the potential of the nurse plant method ...
Stanbrook Matthew B - - 2013
QUESTION Is biomarker- or symptom-based adjustment of inhaled corticosteroid (ICS) dose better than physician assessment-based adjustment for preventing treatment failure in adults with mild to moderate asthma? METHODS DESIGN Randomized, placebo-controlled, 3-group trial (Best Adjustment Strategy for Asthma in the Long Term [BASALT] trial). ClinicalTrials.gov NCT00495157. ALLOCATION Unclear allocation concealment.* ...
Shepherd Kelly - - 2013
Continuous positive airway pressure (CPAP), the mainstay treatment for obstructive sleep apnea (OSA), involves administration of air under pressure to the upper airway. A well-known but poorly understood side effect of positive airway pressure therapies is aerophagia, air entering the esophagus and stomach rather than the lungs. Gastric distension, a ...
Yonemitsu Yoshikazu Y Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. - - 2013
We here report the results of a Phase I/IIa open-label four dose-escalation clinical study assessing the safety, tolerability, and possible therapeutic efficacy of a single intramuscular administration of DVC1-0101, a new gene transfer vector based on a nontransmissible recombinant Sendai virus (rSeV) expressing the human fibroblast growth factor-2 (FGF-2) gene ...
McIntosh Robert A - - 2013
BACKGROUND: Resting echocardiographic measures of cardiac function such as left ventricular ejection fraction correlate poorly with exercise capacity. Assessment during exercise using measures less dependent on hemodynamic loading conditions, such as tissue Doppler imaging (TDI), may more accurately characterize the relationship between cardiac function and exercise capacity. METHODS AND RESULTS: ...
Lefkowitz Robert A RA Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. - - 2013
Myxofibrosarcoma frequently shows curvilinear extensions of high T2 signal that also enhance on magnetic resonance imaging; these "tails" represent fascial extension of tumor at histopathological examination. This study was performed to determine whether the tail sign is helpful in distinguishing myxofibrosarcoma from other myxoid-containing neoplasms. The study group consisted of ...
Tseng L-S - - 2013
Objective: We describe a rare case of sudden onset of unilateral sensorineural hearing loss occurring as the first symptom of moyamoya disease, which is characterised by progressive stenosis of the intracranial internal carotid arteries and their proximal anterior cerebral arteries and middle cerebral arteries. Method: Case report and review of ...
Suchánek Jan - - 2013
The formation of self-assemblies between CdSe quantum dots (QDs) and Zn phthalocyanines (Pc) and azaphthalocyanines (AzaPc) bearing alkylsulfanyl substituents and the photophysical properties of these assemblies were studied using both steady-state and time-resolved luminescence/absorption spectroscopy. The formation of the self-assemblies was accompanied by a blue shift of the Q band ...
Hafeez Shaista - - 2013
Bone metastases cause significant morbidity and mortality in castration-resistant prostate cancer (CRPC). Until recently, treatment options have been limited, but now six drugs are known to extend life expectancy, with docetaxel the current standard first-line cytotoxic therapy. Phase III studies have also shown a survival advantage for sipuleucel-T, cabazitaxel, abiraterone, ...
Banan Mehdi - - 2013
Hydroxyurea (HU) is a drug that induces fetal hemoglobin production. As a result, HU is widely used to treat β-thalassemia (β-thal) patients. However, the response of these patients to HU varies. Some β-thal patients respond favorably to treatment while others do not respond at all. HU has a number of ...
Chen Baowei - - 2013
Arsenic trioxide has been successfully used as a therapeutic in the treatment of acute promyelocytic leukemia (APL). Detailed monitoring of the therapeutic arsenic and its metabolites in various accessible specimens of APL patients can contribute to improving treatment efficacy and minimizing arsenic-induced side effects. This article focuses on the determination ...
Sabounchi N S - - 2013
Basal metabolic rate (BMR) represents the largest component of total energy expenditure and is a major contributor to energy balance. Therefore, accurately estimating BMR is critical for developing rigorous obesity prevention and control strategies. Over the past several decades, numerous BMR formulas have been developed targeted to different population groups. ...
Nelen Stijn D - - 2013
To predict prognosis of gastric cancer, an adequate assessment of the stage of gastric cancer is important. The UICC/AJCC TNM classification is the most commonly used classification system. For adequate N staging at least 15 lymph nodes should be retrieved. In some countries, this amount of lymph nodes is not ...
Lang Chim C - - 2013
The renin-angiotensin-aldosterone system is a well-established therapeutic target in the treatment of heart failure (HF). Substantial advances have been made with existing agents-angiotensin-converting enzyme (ACE) inhibitors, angiotensin II-receptor blockers (ARBs), and mineralocorticoid-receptor antagonists (MRAs)-and new data continue to emerge. The indication for the use of MRAs has been broadened to ...
Spelzini Federico - - 2013
INTRODUCTION AND HYPOTHESIS: The aim of this study was to evaluate the functional outcome of a single-incision sling procedure for the treatment of female stress urinary incontinence (SUI) and to correlate the cure rate with a pelvic floor ultrasound examination METHODS: Fifty-seven patients treated with a single-incision sling procedure between ...
Mohammadi Morteza - - 2013
In this work, the two mixtures of ionic liquid 1-n-propyl-4-amino-1,2,4-triazolium bromide and each type of the aggregated single-walled carbon nanotubes (SWCNTs), i.e. bundled SWCNTs and non-bundled, were investigated using molecular dynamics (MD) simulations. The structural characteristics of a SWCNT in the ionic liquid (IL) were examined by analyzing the radial ...
Wu R Y - - 2013
Background  Commensal bacteria such as probiotics that are neuroactive acutely affect the amplitudes of intestinal migrating motor complexes (MMCs). What is lacking for an improved understanding of these motility effects are region specific measurements of velocity and frequency. We have combined intraluminal pressure recordings with spatiotemporal diameter maps to analyze ...
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