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Results 701 - 750 of 2924
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Li Zhe - - 2013
Zn(II) complexes of the following new, fluorine-containing, benzothiazole-derived ligands have been synthesized and characterized crystallographically: 2-(3,3,3-trifluoro-2-oxopropyl)benzothiazole (3), 4,5,6,7-tetrafluoro-2-(3,3,3-trifluoro-2-oxopropyl)benzothiazole (4), 4,5,6,7-tetrafluoro-2-(2-hydroxyphenyl)benzothiazole (12), 2-(3,4,5,6-tetrafluoro-2-hydroxyphenyl)-4,5,6,7-tetrafluorobenzothiazole (13), and 2-(3,4,5,6-tetrafluoro-2-hydroxyphenyl)benzothiazole (16); the Cu(II) complex of ligand 4 is also reported. These are analogs of the important photo- and electroluminescent material [Zn(BTZ)(2)](2), where H-BTZ = 2-(2-hydroxyphenyl)benzothiazole. ...
Fischer Benedikt - - 2013
PURPOSE: Prescription opioid analgesic (POA)-related burden of disease - including mortality - is high and constitutes a major public health problem in the US and Canada. Associations between the overall levels of POA consumption and key related morbidity indicators in the population have been demonstrated. We examined potential correlations between ...
Fidder Henk - - 2013
Dynamics and couplings of N-H stretching vibrations of chemically modified guanosine-cytidine (G•C) base pairs in chloroform are investigated with linear infrared spectroscopy and ultrafast two-dimensional infrared (2D-IR) spectroscopy. Comparison of G•C absorption spectra before and after H/D exchange reveals significant N-H stretching absorption in the region from 2500 up to ...
Naganathan Saranga - - 2013
We developed a general strategy to label expressed membrane proteins with a peptide-epitope tag and to detect the tagged proteins in native cellular membranes. First, we genetically encoded the unnatural amino acid, p-azido-L-phenylalanine (azF) at various specific sites in a G protein-coupled receptor (GPCR), C-C chemokine receptor 5 (CCR5). The ...
Edwards Kate M - - 2013
The role of exercise in health is well known; here we discuss the specific role of exercise in vaccination responses. Chronic exercise or high levels of physical activity have been shown to be related to improved vaccination responses in older adults, illustrating improved immune function, and conferring potentially significant public ...
Rahman Shofiqur - - 2013
This commentary summarizes the laboratory investigations and clinical trials published recently involving per-oral application of IgY supplemented food for specific orogastrointestinal disease prevention and control purposes. The prolonged use and misuse of conventional antibacterial drugs has spawned antibiotic resistant microbes prompting scientists to search for other germ-killing options. In particular, ...
Itoi Toshiyuki - - 2013
BACKGROUND: The angiotensin type 2 (AT2)-receptor plays a unique role on growth inhibition in adult myocardium via modulation of ceramide synthesis. Angiotensin type 1 (AT1)-receptor blockade results in increased AT2-receptor activation by angiotensin II, and AT1-receptor blockers are sometimes prescribed to children for the treatment of cardiac hypertrophy or heart ...
Mohapatra Prasanta K - - 2013
Two new diglycolamide-based task-specific ionic liquids (DGATSILs) were evaluated for the extraction of actinides and lanthanides from acidic feed solutions. These DGATSILs were capable of exceptionally high extraction of trivalent actinide ions, such as Am(3+) , and even higher extraction of the lanthanide ion, Eu(3+) (about 5-10 fold). Dilution of the ...
Kim Dongeun - - 2013
Ir(I)-catalyzed enantioselective decarboxylative allylic etherification of aryl allyl carbonates provides aryl allyl ethers. Key to the generality and high stereoselection of the reaction is the use of the intramolecular decarboxylative allylation process and [Ir(dbcot)Cl](2) as an Ir(I) source. Ir(I)-catalyzed diastereoselective decarboxylative allylic etherification, combined with asymmetric aldehyde crotylation and cross ...
Gibbs Gerald V - - 2013
The bonded radii for more than 700 bonded pairs of atoms, comprising more than 50 oxide crystals, extracted from experimental and theoretical electron density distributions, are averaged and compared with the ionic radii for first, second and third row atoms. At odds with the assumption of a 'fixed' ionic radius ...
Erogbogbo Folarin - - 2013
We demonstrate that nanosize silicon (~10 nm diameter) reacts with water to generate hydrogen 10,000 times faster than bulk silicon, 100 times faster than previously reported Si structures and 6 times faster than competing metal formulations. The H2 production rate using 10 nm Si is 150 times that obtained using ...
Cabezas Carlos - - 2013
Microwave spectroscopy has been applied to characterize the conformations adopted in the gas phase by a small peptide derived from alanine, N-acetyl-l-alaninamide (Ac-Ala-NH(2)). This compound was vaporized by laser ablation and shown to exist as a mixture of C and C(5) conformers stabilized by a COHN intramolecular hydrogen bond closing ...
Poraty Limor - - 2013
How plants coordinate developmental processes and environmental stress responses is a pressing question. Here, we show that Arabidopsis AtROP6 integrates developmental and pathogen response signaling. AtROP6 expression is induced by auxin and detected in the root meristem, lateral root initials, and leaf hydathodes. Plants expressing a dominant negative AtROP6 (rop6DN) ...
Friedman Mendel - - 2013
  We evaluated the relative bactericidal activities (BA(50) ) of 10 presumed health-promoting food-based powders (nutraceuticals) and, for comparison, selected known components against the following foodborne pathogens: Escherichia coli O157:H7, Salmonella enterica, Listeria monocytogenes, and Staphylococcus aureus. The relative activities were evaluated using quantitative bactericidal activity [(BA(50) value, defined as ...
Ichim G - - 2013
Chromosomes are dynamic structures that must be reversibly condensed and unfolded to accommodate mitotic division and chromosome segregation. Histone modifications are involved in the striking chromatin reconfiguration taking place during mitosis. However, the mechanisms that regulate activity and function of histone-modifying factors as cells enter and exit mitosis are poorly ...
Qin Zhihai - - 2013
Nonresolving inflammation is a hallmark of many types of tumors and the molecular mechanisms maintaining this inflammation are still largely unknown. In a two stage carcinogenesis model, we observed here that the lack of IFNγ receptor or neutralization of IFNγ accelerated spontaneous papilloma regression in mice. The impaired maintenance of ...
Zytoon Ashraf Anas - - 2013
BackgroundOvarian cancer has the highest mortality of all gynecologic malignancies. FDG-PET/CT was proven to be accurate for identification of primary ovarian tumors, regional lymph nodes, and distant metastases.PurposeTo evaluate ovarian masses at FDG-PET/CT in correlation with histopathologic findings.Material and MethodsNinety-eight patients underwent whole body FDG-PET/CT examination. Eighty-six patients with primary ...
Grillner Sten - - 2013
The group of nuclei within the basal ganglia of the forebrain is central to the control of movement. We present data showing that the structure and function of the basal ganglia has been conserved throughout vertebrate evolution over some 560 million years. The interaction between the different nuclei within the ...
Moles Angela T - - 2013
Most plant species have a range of traits that deter herbivores. However, understanding of how different defences are related to one another is surprisingly weak. Many authors argue that defence traits trade off against one another, while others argue that they form coordinated defence syndromes. We collected a dataset of ...
Woodburn Kathryn W - - 2013
Peginesatide, a PEGylated peptide-based erythropoiesis stimulating agent (ESA), stimulates the erythropoietin (EPO) receptor dimer that governs erythropoiesis. Studies were designed to determine the erythropoietic response, pharmacokinetics (PK), tissue distribution, metabolism, and excretion of peginesatide in nonhuman primates following a single intravenous (IV) dose. The PK profile of peginesatide (0.1 to ...
Breglia Susana A - - 2013
Euglenids comprise a distinct clade of flagellates with diverse modes of nutrition, including phagotrophy, osmotrophy and phototrophy. Much of the previous research on euglenids has focused on phototrophic species because of their ecological abundance and significance as indicators for the health of aquatic ecosystems. Although largely understudied, phagotrophic species probably ...
Lumbroso Alexandre - - 2013
Allylic alcohols represent an important and highly versatile class of chiral building blocks for organic synthesis. This Review summarizes the plethora of methods developed for the catalytic asymmetric synthesis of enantioenriched allylic alcohols. These include: dynamic kinetic resolution (DKR/DKAT), nucleophilic 1,2-addition to carbonyl groups, allylic substitution, oxidation of CH bonds, ...
Maguire Jonathon L - - 2013
OBJECTIVES To determine the effect of modifiable dietary intake variables (current vitamin D supplementation and daily cow's milk intake) on 25-hydroxyvitamin D level in early childhood and to evaluate the relationship between these modifiable dietary factors and other largely nonmodifiable determinants of vitamin D status including skin pigmentation and season. ...
Zhai C - - 2013
ORAOV1 (oral cancer overexpressed) is overexpressed in many solid tumours, making a key contribution to the development of cancer, but the cellular role of ORAOV1 is unknown. The yeast orthologue of this protein is encoded by the hitherto uncharacterized essential gene, YNL260c. Expression of ORAOV1 restores viability to yeast cells ...
MacEnri Joseph - - 2013
This paper presents the analysis of the study of the flicker emitted from the 1.2 MW tidal energy converter (TEC), SeaGen, against varying tidal parameters. This paper outlines the main elements of the TEC itself, the environment it is located in and the measurement set up. In this paper, the flicker ...
Kulesza Urszula - - 2013
1alpha,25-(OH)2-9alpha-Methyl-vitamin D3 (4), the first known analog of the natural hormone 1alpha,25-(OH)2D3 (3) with an alkyl substituent at C-9, and two 1alpha,25-(OH)2-9-methylene-10,19-dihydrovitamin D3 analogs (7 and 8) with an unprecedented non-natural triene system were synthesized by thermal isomerization of 1alpha,25-(OH)2-9-methyl-previtamin D3 (6). Three alternative approaches (Sonogashira, Stille or stereoselective dehydration ...
Bai Dorothy Li - - 2013
Introduction: Few women who reside in Hong Kong exclusively breastfeed, and one-half stop breastfeeding within the first few months. There is little research in this population on the association between intrapartum interventions and breastfeeding duration. Methods: A sample of 1280 mother-infant pairs were recruited from the obstetric units of 4 ...
Jarava-Barrera Carlos - - 2013
Dihydroarylfuran skeletons are efficiently synthesized from (Z)-bromonitroalkenes and naphthol derivatives in good yields and excellent enantioselectivities by using squaramide catalysis.
Epstein Dana R - - 2013
PURPOSE: The study determined the feasibility of implementing a brief, preference-based non-medication insomnia treatment for Iraq/Afghanistan war Veterans who experienced blast and/or other injuries resulting in an altered level of consciousness. METHODS: The study used a one-group pre-post design with a 3-month follow-up assessment. Forty-one veterans (two females, mean age ...
Raja S - - 2013
Optimal treatment of esophageal small-cell cancer, a rare disease, lacks consensus. Based on its lung small-cell cancer analog, we hypothesized that chemotherapy with adjuvant radiotherapy would be optimal. This hypothesis was tested by studying the collective published literature. A meta-analysis of individual patients from 148 articles (1952-2010) explored treatment and ...
Demont A - - 2013
An original Ruddlesden-Popper phase, La(0.77)Sr(3.23)Co(2.75)C(0.25)O(8.40+δ), was isolated and studied by electron, X-ray, and neutron diffraction. This structure has complex crystal chemistry resulting from a high degree of flexibility in the structure, comprising the disordered introduction of carbonates into a cobalt layer and an important oxygen deficiency with a preferential repartition ...
Lee Han-Bo-Ram - - 2013
The formation of Pt nanowires (NWs) by atomic layer deposition on highly ordered pyrolytic graphite (HOPG) is investigated. Pt is deposited only at the step edges of HOPG and not on the basal planes, leading to the formation of laterally aligned Pt NWs. A growth model involving a morphological transition ...
Ramírez N - - 2013
Recipients of hematopoietic SCT undergo a period of profound immunosuppression due to the chemotherapy and/or radiotherapy used for the conditioning and to the graft versus host reaction. SCT patients are highly susceptible to the development of viral infections such as CMV or EBV. The achievement of a competent immunological response, ...
Lee Jae H T - - 2013
Abstract Spinal cord injury (SCI) researchers have predominately utilized rodents and mice for in vivo SCI modeling and experimentation. From these small animal models have come many insights into the biology of SCI, and a growing number of novel treatments that promote behavioral recovery. It has, however, been difficult to ...
Wang Kui - - 2013
BACKGROUND: EGFR and β-catenin are two key mediators of cell signal transduction implicated in the pathogenesis of a variety of tumors. There is emerging evidence indicating that they are overexpressed in glioblastoma multiforme (GBM) and both play significant roles in GBM carcinogenesis. Moreover, down-regulating EGFR individually only provide limited therapeutic ...
Hwang Jongkook - - 2013
We report a facile 'one-pot' method for the synthesis of Sn embedded carbon-silica (CS) mesostructured (nanostructured) composites through the selective interaction of resol (carbon precursor), tetraethylorthosilicate (TEOS), and tributylphenyltin (Sn precursor) with an amphiphilic diblock copolymer, poly (ethylene oxide-b-styrene), PEO-b-PS. A unique morphology transition from Sn nanowires to spherical Sn ...
Lu Kai - - 2013
The formation of relevant biological structures poses a challenge for regenerative medicine. During embryogenesis, embryonic cells differentiate into somatic tissues and undergo morphogenesis to produce three-dimensional organs. Using stem cells, we can recapitulate this process and create biological constructs for therapeutic transplantation. However, imperfect imitation of nature sometimes results in ...
Ellwood Philippa - - 2013
BACKGROUND: Certain foods may increase or decrease the risk of developing asthma, rhinoconjunctivitis and eczema. We explored the impact of the intake of types of food on these diseases in Phase Three of the International Study of Asthma and Allergies in Childhood. METHODS: Written questionnaires on the symptom prevalence of ...
Makdasi Efi - - 2013
L chain allelic inclusion has been proposed as a B cell tolerance mechanism in addition to clonal deletion, clonal anergy, and receptor editing. It is said to rescue autoreactive B cells from elimination by diluting out the self-reactive BCR through the expression of a second innocuous L chain. In autoimmune ...
Byun Chang Kyu - - 2013
This paper describes a system to study how small physical perturbations can affect bacterial community behavior in unexpected ways through modulation of diffusion and convective transport of chemical communication molecules and resources. A culture environment that mimics the chemically open characteristic of natural bacterial habitats but with user-defined spatio-temporal control ...
Daniels Judith K - - 2013
Recent reviews and meta-analyses reported structural gray matter changes in patients suffering from adult-onset posttraumatic stress disorder (PTSD) and in subjects with and without PTSD who experienced childhood trauma. However, it remains unclear if such structural changes are also affecting the white matter. The aim of this systematic review is ...
Yates Nick - - 2013
A two-dimensional west coast tidal model, built on the ADCIRC platform (an unstructured grid two-dimensional depth-integrated shallow water model), has been developed to examine the scope for reliable and fully predictable electricity generation from UK coastal waters using an ambitious combination of estuary barrages, tidal lagoons and tidal stream generator ...
Fitneva Stanka A - - 2013
The testimony of others and direct experience play a major role in the development of children's knowledge. Children actively use questions to seek others' testimony and explore the environment. It is unclear though whether children distinguish when it is better to ask from when it is better to try to ...
Janeliunas Dainius - - 2013
Come together: Self-assembly can drive the formation of conjugated imine polymers in water, and stabilization of otherwise unstable imine bonds is used to obtain fully π-conjugated, responsive dynamic covalent polyimines in aqueous environments. Both the optical properties and the aggregate morphology can be tuned by varying the aromatic monomers.
Peterson Amy M - - 2013
The Diels-Alder reaction was used to yield thermal reversibility of the bonding between a partially furan functionalized epoxy thermosetting matrix and a maleimide treated glass fiber. Under ambient temperature conditions the covalent bond forming product reaction dominates, but this reaction reverses at elevated temperatures to allow for interfacial healing. Single ...
Vesikari Timo - - 2013
Disease protection provided by herpes zoster (HZ) vaccination tends to reduce as age increases. This study was designed to ascertain whether a second dose of the HZ vaccine, Zostavax (®) , would increase varicella zoster virus (VZV)-specific immune response among individuals aged ≥ 70 y. Individuals aged ≥ 70 y ...
Gu Yan - - 2013
Graphene wrapped CoS nanoparticles are synthesized by a solvothermal approach. The product is significantly different from porous CoS microspheres prepared in the absence of graphene under similar preparation conditions. The CoS microspheres and CoS/graphene composite are fabricated as anode materials for lithium ion batteries. The CoS/graphene composite is found to ...
Alverson Dale C - - 2013
Abstract An overview of the Center for Telehealth and Cybermedicine Research at the University of New Mexico Health Sciences Center was presented along with several other national and international programs as part of the of a symposium-workshop on telehealth, "Sustaining and Realizing the Promise of Telemedicine," held at the University ...
Kumari U - - 2013
Fanconi Anemia (FA) is a rare genetic disorder associated with a bone-marrow failure, cancer predisposition and hypersensitivity to DNA crosslinking agents. Majority of the 15 FA genes and encoded proteins characterized so far are integrated into DNA repair pathways, however, other important functions cannot be excluded. FA cells are sensitive ...
De Miranda Briana - - 2013
There are currently no registered drugs that slow the progression of neurodegenerative diseases, in part because translation from animal models to the clinic has been hampered by poor distribution to brain. The present studies examined a selected series of para-phenyl substituted diindolylmethane (C-DIM) compounds that display anti-inflammatory and neuroprotective efficacy ...
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