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Bell Matthew C - - 2013
Two alternative approaches describe determinants of responding to a stimulus temporally distant from primary reinforcement. One emphasizes the temporal relation of each stimulus to the primary reinforcer, with relative proximity of the stimulus determining response rate. A contrasting view emphasizes immediate consequences of responding to the stimulus, the key factor ...
Camps Jordi - - 2013
Chromosomal copy number alterations (aneuploidy) define the genomic landscape of most cancer cells, but identification of the oncogenic drivers behind these imbalances remains an unfinished task. In this study, we conducted a systematic analysis of colorectal carcinomas that integrated genomic copy number changes and gene expression profiles. This analysis revealed ...
Khan Tahsin N TN Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, - - 2013
Mer receptor tyrosine kinase is a member of the Tyro-3/Axl/Mer (TAM) subfamily of receptor tyrosine kinases, and its expression on phagocytes facilitates their clearance of apoptotic cells (ACs). Mer expression in germinal centers (GCs) occurs predominantly on tingible body macrophages. B and T cells do not express Mer. In this ...
Jiang Yaping - - 2013
Toxic α-dicarbonyl compounds, glyoxal, 2-methylglyoxal and diacetyl (2,3-butanedione) released from the headspace from butter, margarine, safflower oil, beef fat and cheese heated at 100 and 200 °C were analyzed by gas chromatography as quinoxaline derivatives. Total amounts of α-dicarbonyl compounds ranged from 40.5 ng/g (butter) to 331.2 ng/g (beef fat) ...
El Kholy Amani A - - 2013
BACKGROUND: Respiratory syncytial virus (RSV) is the main cause of severe acute respiratory infection (SARI) in infants and young children. This study aimed to identify risk factors for intensive care unit (ICU) admission, prolonged length of stay (PLOS), and mortality in patients hospitalized with SARI caused by RSV. METHODS: A ...
Zhang Xiaobing X Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, - - 2013
Dynorphin, an endogenous ligand of kappa (κ) opioid receptors, has multiple roles in the brain, and plays a positive role in energy balance and food intake. However, the mechanism for this is unclear. With immunocytochemistry, we find that axonal dynorphin immunoreactivity in the arcuate nucleus is strong, and that a ...
Zhan C - - 2013
It's frequently stated that the pyruvate kinase M2 (PKM2) and Warburg effect are important for cancer development by accumulating more raw materials for macromolecule biosynthesis. However, the correlation between PKM2 and cancer is poorly reported. Here, we investigated the PKM2 expression in esophageal squamous cell cancer (ESCC). We observed that ...
Warner Douglas M DM Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts, - - 2013
A carbapenem-resistant clinical isolate of Escherichia coli, which lacked OmpF and OmpC porins, carried a marR mutation and expressed a functional yedS, a normally nontranslated gene. MarR and YedS are described here as having effects on the ability of this strain to resist carbapenems. Additionally, expression of YedS was regulated ...
Jiang Zhi-Qiang - - 2013
Modern technologies not only provide a variety of communication modes (e.g., texting, cell phone conversation, and online instant messaging), but also detailed electronic traces of these communications between individuals. These electronic traces indicate that the interactions occur in temporal bursts. Here, we study intercall duration of communications of the 100,000 ...
Chen H Y - - 2013
Carbon nanotubes: The end section of a carbon nanotube, cut by acid treatment, contains hydrophilic oxygen groups, around which water molecules can assemble to block the entry of the tube. Hydrogen of pressures up to 10 000 bar can be locked inside the tube by such an "aqueous valve".
Wang Long - - 2013
Sodium manganese hexacyanoferrates (NMHFCs) synthesized in aqueous solution at room temperature show high reversible capacity and outstanding rate capability as cathodes for a rechargeable sodium-ion battery (SIB). Earth-abundant elements and a low-cost synthesis route make these NMHFCs promising cathodes for SIBs, independent of natural lithium sources.
Usui Ayumi - - 2013
Sry-related HMG box (Sox) proteins, Sox11 and Sox4 are members of the SoxC subtype. We found that Sox11 was strongly expressed in early retinal progenitor cells and that Sox4 expression began around birth, when expression of Sox11 subsided. To analyze the roles of Sox11 and Sox4 in retinal development, we ...
Song Lihua - - 2013
Chlamydia trachomatis causes chronic inflammatory diseases of the eye and genital tract and has global medical importance. The chlamydial plasmid plays an important role in the pathophysiology of these diseases, as plasmid-deficient organisms are highly attenuated. The cryptic plasmid carries noncoding RNAs and eight conserved open reading frames (ORFs). To ...
Edwards Rachel L - - 2013
In response to environmental fluctuations or stresses, bacteria can activate transcriptional and phenotypic programs to coordinate an adaptive response. The intracellular pathogen Legionella pneumophila converts from a noninfectious replicative form to an infectious transmissive form when the bacterium encounters alterations in either amino acid concentrations or fatty acid biosynthesis. Here, ...
Liu Y Y Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY, - - 2014
The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in ∼20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM ...
Pan Jingxi - - 2013
High-resolution structural characterization of post-translationally-modified proteins represents a challenge for traditional structural biology methods such as crystallography and NMR. In this study, we have used top-down hydrogen/deuterium exchange mass spectrometry (HDX-MS) with precursor ion selection and electron capture dissociation (ECD) to determine the impact of oxidative modification on calmodulin (CaM) ...
Catania Gianluca - - 2013
ABSTRACT: BACKGROUND: Palliative Care (PC) is an approach that improves the Quality of Life (QoL). A number of QoL assessment tools have been developed and validated in PC. It is not clear how QoL should be measured in PC practice. A procedure of QoL assessment in clinical practice can be ...
Clausen Torben - - 2013
In skeletal muscle, excitation leads to increased [Na(+)](i), loss of K(+), increased [K(+)](o), depolarization, and Cl(-) influx. This study quantifies these changes in rat extensor digitorum longus (EDL) muscles in vitro and in vivo using flame photometric determination of Na(+) and K(+) and (36)Cl as a tracer for Cl(-). In ...
Viel Pascal - - 2013
Covalent immobilization of non-modified biological materials as proteins has been performed through a one-step and soft method. This process is based on polyazidophenylene layer derived from the electroreduction of the parent salt 4-azidobenzenediazonium tetrafluoborate on gold substrates. Wavelength used (365 nm) for the photochemical grafting of a large variety of ...
Moretti Silvia - - 2013
Recent studies sight β-adrenergic receptor (AR) antagonists as novel therapeutic agents for melanoma, as they may reduce disease progression. Here within, we evaluated the expression of β-ARs in a series of human cutaneous melanocytic lesions, and studied the effect of their endogenous agonists, norepinephrine (NE) and epinephrine (E), on primary ...
Valcárcel David - - 2013
PURPOSEComplex karyotype (CK) is the poorest risk factor in patients with myelodysplastic syndrome (MDS). It has recently been reported that monosomal karyotype (MK) worsens the prognosis of patients with CK. PATIENTS AND METHODSWe analyzed 1,054 adult patients with MDS with an abnormal karyotype from the Spanish Registry of MDS. The ...
Bardak-Ozcem Selin - - 2013
In this study, we aimed to compare the antibacterial activities of daptomycin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 43300) in an experimental rabbit meningitis model. After an 8-h period of treatment, bacterial counts decreased significantly in both treatment groups compared ...
He Yinghong - - 2013
ABSTRACT: BACKGROUND: Pharmacologic reactivation of fetal hemoglobin expression is a promising strategy for treatment of sickle cell disease and beta-thalassemia. The objective of this study was to investigate the effect of the methyl transferase inhibitor adenosine-2[prime],3[prime]-dialdehyde (Adox) on induction of human fetal hemoglobin (HbF) in K562 cells and human hematopoietic ...
Bajaj Pavan - - 2013
BACKGROUND: The treatment of molar furcation defects remains a considerable challenge in clinical practice. The identification of clinical measurements influential to treatment outcomes is critical to optimize the results of surgical periodontal therapy. The present study aimed to explore the clinical and radiographical effectiveness of autologous platelet-rich fibrin (PRF) and ...
Furuya Yuriko - - 2013
To date, parathyroid hormone is the only clinically available bone anabolic drug. The major difficulty in the development of such drugs is the lack of clarification of the mechanisms regulating osteoblast differentiation and bone formation. Here, we report a peptide (W9) known to abrogate osteoclast differentiation in vivo via blocking ...
Zhou Zhixue - - 2013
Endonuclease plays an important role in many biological processes, and assay of endonuclease activity is of great significance. However, traditional methods for the assay of endonuclease activity exist undesirable limitations, such as high cost, DNA-consuming and laboriousness. In the present work, a G-quadruplex-based, label-free, fluorescent assay of endonuclease activity has ...
Teoh-Fitzgerald M L ML Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA, - - 2014
Expression of the antioxidant enzyme EcSOD in normal human mammary epithelial cells was not recognized until recently. Although expression of EcSOD was not detectable in non-malignant human mammary epithelial cells (HMEC) cultured in conventional two-dimensional (2D) culture conditions, EcSOD protein expression was observed in normal human breast tissues, suggesting that ...
Bregman Howard - - 2013
Potent and selective inhibitors of tankyrases have recently been characterized to bind to an induced pocket. Here we report the identification of a novel potent and selective tankyrase inhibitor that binds to both the nicotinamide pocket and the induced pocket. The crystal structure of human TNKS1 in complex with this ...
Churchfield Matthew J - - 2013
This paper presents our initial work in performing large-eddy simulations of tidal turbine array flows. First, a horizontally periodic precursor simulation is performed to create turbulent flow data. Then those data are used as inflow into a tidal turbine array two rows deep and infinitely wide. The turbines are modelled ...
Rafiq Sajjad - - 2013
Genome-Wide Association Studies (GWAS) have begun to investigate associations between inherited genetic variations and breast cancer prognosis. Here, we report our findings from a GWAS conducted in 536 patients with early-onset breast cancer aged 40 or less at diagnosis and with a mean follow-up period of 4.1 years (SD = ...
Huang Yufen - - 2013
To accelerate the drug development process and shorten approval time, the design of multiregional clinical trials (MRCTs) incorporates subjects from many countries/regions around the world under the same protocol. After showing the overall efficacy of a drug in all global regions, one can also simultaneously evaluate the possibility of applying ...
Seo Byung-Kwan - - 2013
ABSTRACT: BACKGROUND: Chronic non-specific low back pain is the most common medical problem for which patients seek complementary and alternative medical treatment, including bee venom acupuncture. However, the effectiveness and safety of such treatments have not been fully established by randomized clinical trials. The aim of this study is to ...
Takano Tomomi - - 2013
The ST5 lineage of methicillin-resistant Staphylococcus aureus (MRSA) is one of the most globally disseminated hospital-associated MRSA (HA-MRSA) lineages. We isolated a new local variant (designated ST764) over at least 5 years that causes invasive infections, including necrotizing fasciitis, and is carried by medical students, as well as household members. ...
Guo Yanan Y Division of Translational Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, - - 2013
AKT is a critical signaling node downstream of phosphoinositide 3-kinase (PI3K), which is often activated in cancer. We analyzed the state of activation of AKT in 80 human non-small cell lung carcinoma cell lines under serum starvation conditions. We identified 13 lines, which showed persistent AKT activation in the absence ...
Marzi Andrea - - 2013
Ebola viruses cause hemorrhagic disease in humans and nonhuman primates with high fatality rates. These viruses pose a significant health concern worldwide due to the lack of approved therapeutics and vaccines as well as their potential misuse as bioterrorism agents. Although not licensed for human use, recombinant vesicular stomatitis virus ...
Li Zhe - - 2013
Zn(II) complexes of the following new, fluorine-containing, benzothiazole-derived ligands have been synthesized and characterized crystallographically: 2-(3,3,3-trifluoro-2-oxopropyl)benzothiazole (3), 4,5,6,7-tetrafluoro-2-(3,3,3-trifluoro-2-oxopropyl)benzothiazole (4), 4,5,6,7-tetrafluoro-2-(2-hydroxyphenyl)benzothiazole (12), 2-(3,4,5,6-tetrafluoro-2-hydroxyphenyl)-4,5,6,7-tetrafluorobenzothiazole (13), and 2-(3,4,5,6-tetrafluoro-2-hydroxyphenyl)benzothiazole (16); the Cu(II) complex of ligand 4 is also reported. These are analogs of the important photo- and electroluminescent material [Zn(BTZ)(2)](2), where H-BTZ = 2-(2-hydroxyphenyl)benzothiazole. ...
Fischer Benedikt - - 2013
PURPOSE: Prescription opioid analgesic (POA)-related burden of disease - including mortality - is high and constitutes a major public health problem in the US and Canada. Associations between the overall levels of POA consumption and key related morbidity indicators in the population have been demonstrated. We examined potential correlations between ...
Grueter Brad A BA Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, - - 2013
Synaptic modifications in nucleus accumbens (NAc) medium spiny neurons (MSNs) play a key role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction. NAc MSNs participate in two parallel circuits, direct and indirect pathways that subserve distinct behavioral functions. Modification of NAc MSN synapses may occur ...
Fidder Henk - - 2013
Dynamics and couplings of N-H stretching vibrations of chemically modified guanosine-cytidine (G•C) base pairs in chloroform are investigated with linear infrared spectroscopy and ultrafast two-dimensional infrared (2D-IR) spectroscopy. Comparison of G•C absorption spectra before and after H/D exchange reveals significant N-H stretching absorption in the region from 2500 up to ...
Naganathan Saranga - - 2013
We developed a general strategy to label expressed membrane proteins with a peptide-epitope tag and to detect the tagged proteins in native cellular membranes. First, we genetically encoded the unnatural amino acid, p-azido-L-phenylalanine (azF) at various specific sites in a G protein-coupled receptor (GPCR), C-C chemokine receptor 5 (CCR5). The ...
Edwards Kate M KM Exercise Health and Performance Research Group; University of Sydney; Lidcombe, NSW - - 2013
The role of exercise in health is well known; here we discuss the specific role of exercise in vaccination responses. Chronic exercise or high levels of physical activity have been shown to be related to improved vaccination responses in older adults, illustrating improved immune function, and conferring potentially significant public ...
Rahman Shofiqur S Immunology Research Institute in Gifu; EW Nutrition Japan; Sano, Gifu - - 2013
This commentary summarizes the laboratory investigations and clinical trials published recently involving per-oral application of IgY supplemented food for specific orogastrointestinal disease prevention and control purposes. The prolonged use and misuse of conventional antibacterial drugs has spawned antibiotic resistant microbes prompting scientists to search for other germ-killing options. In particular, ...
Silva Nuno A NA 3B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, - - 2013
Adipose-derived adult stem cells (ASCs), bone marrow mesenchymal stem cells (bmMSCs), and human umbilical cord perivascular cells (HUCPVCs) tissue have been widely tested for regenerative applications, such as bone regeneration. Moreover, olfactory ensheathing cells (OECs) show promise in promoting spinal cord injury (SCI) regeneration. Our group recently proposed the use ...
Standley Eric A EA Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2013
The synthesis and characterization of the air-stable nickel(II) complex trans-(PCy(2)Ph)(2)Ni(o-tolyl)Cl is described in conjunction with an investigation of its use for the Mizoroki-Heck-type, room temperature, internally selective coupling of substituted benzyl chlorides with terminal alkenes. This reaction, which employs a terminal alkene as an alkenylmetal equivalent, provides rapid, convergent access ...
Stöck M - - 2013
Contrasting with birds and mammals, most ectothermic vertebrates present homomorphic sex chromosomes, which might be due either to a high turnover rate or to occasional X-Y recombination. We tested these two hypotheses in a group of Palearctic green toads that diverged some 3.3 million years ago. Using sibship analyses of sex-linked ...
Patton Susana R SR Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. - - 2013
Electronic measures of adherence can be superior to patient report. In type 1 diabetes, frequency of blood glucose monitoring (BGM), as measured by patients' home blood glucose meters, has already been identified as a valid proxy of adherence. We present methodology to calculate adherence using insulin pump records and evaluate ...
Sawatzky Jo-Ann V - - 2013
AIMS: To describe and compare the outcomes of a nurse practitioner-managed cardiac surgery follow-up model of care with the standard model of primary care provider follow-up for coronary artery bypass graft surgery patients. BACKGROUND: Advances in healthcare have had a favourable impact on length of stay following cardiac surgery; however, ...
Kawasaki Keitarou - - 2013
Chronic inflammation is an important contributor to the development and progression of metabolic syndrome. Recent evidence indicates that, in addition to innate immune cells, adaptive immune cells have an important role in this process. We previously showed that the serum level of B-cell-activating factor (BAFF) was increased in patients with ...
Hong Sun-Hae - - 2013
We measured the distance between fluorescent-labeled DNA loci of various interloci contour lengths in Caulobacter crescentus swarmer cells to determine the in vivo configuration of the chromosome. For DNA segments less than about 300 kb, the mean interloci distances, <r>, scale as n(0.22), where n is the contour length, and ...
Caucheteux Stephane M - - 2013
The proportion of CD4 T cells with phenotypic and functional properties of naïve cells out of total CD4 T cells is similar in the lung parenchyma and lymph nodes. On treatment with a sphingosine-1-phosphate agonist, the frequency of these cells falls precipitously, but with a delay of ∼14 h compared ...
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