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Xun Miao-Miao - - 2013
Non-viral gene vectors play an important role in the development of gene therapy. In this report, different hydrophobic chains were introduced into low molecular weight (LMW) PEI-based biodegradable oligomers to form a series of lipopolymers (LPs), and their structure-activity relationships were studied. Results revealed that the nine polymers can condense ...
Leyssens Carlien - - 2013
The active form of vitamin D3, 1,25(OH)2D3, is mostly known for its important functions to maintain calcium and phosphate homeostasis. However, next to its classical effects on bone, kidney and intestine, 1,25(OH)2D3 also exerts antineoplastic effects on various types of cancer. The use of 1,25(OH)2D3 itself as treatment against neoplasia ...
Lu Ganhua - - 2013
Interest in graphene has grown extensively in the last decade or so, because of its extraordinary physical properties, chemical tunability, and potential for various applications. However, graphene is intrinsically a semimetal with a zero bandgap, which considerably impedes its use in many applications where a suitable bandgap is required. The ...
Gong Hui - - 2013
PURPOSE: Constitutive activation of nuclear factor-κB (NF-κB) signaling plays vital roles in esophageal squamous cell carcinoma (ESCC) progression. The aim of this study was to evaluate the effect of miR-138 on NF-κB activation and ESCC progression. EXPERIMENTAL DESIGN: Expression of miR-138 in ESCC cell lines, ESCC tissues and 205 archived ...
Kuwahara Shunsuke - - 2013
Chirality transcription and amplification by the formation of chiral [2]pseudorotaxanes by an achiral crown ether having the 2',2''-quaterphenyl group and chiral sec-ammonium ions are reported. It was revealed that the absolute configurations of the chiral sec-ammonium ions can be detected directly from the CD spectra of the chiral [2]pseudorotaxanes.
Poddutoori Prashanth K - - 2013
Two self-assembled supramolecular donor-acceptor triads consisting of Al(III) porphyrin (AlPor) with axially bound naphthalenediimide (NDI) as an acceptor and tetrathiafulvalene (TTF) as a secondary donor are reported. In the triads, the NDI and TTF units are attached to Al(III) on opposite faces of the porphyrin, through covalent and coordination bonds, ...
Order Berndt-Michael - - 2013
BackgroundBreast cancer screening programs have been established worldwide and early detection of breast cancer has increased steadily. The most common way to confirm dignity of non-palpable and sonographically-occult suspicious findings on mammography is the stereotactically-guided vacuum-assisted breast biopsyPurposeTo compare two stereotactically guided vacuum-assisted breast biopsy systems measuring time effectiveness and ...
Sudo Noriko - - 2013
ABSTRACT: BACKGROUND: Focal ground-glass opacity (GGO) on thin-section computed tomography (CT) may be seen in atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ that has recently been renamed from bronchioloalveolar carcinoma (BAC) and various benign conditions. CASE PRESENTATION: We report a case of pulmonary focal fibrosis associated with microscopic arterio-venous fistula ...
Peirano Gisele - - 2013
The success of certain sequence types such as ST131 that produce CTX-Ms or NDMs and ST405 with CTX-Ms among extraintestinal E. coli (ExPEC) had previously been linked to a combination of antimicrobial resistance and certain virulence factors. The adherence properties of these sequence types to gastro-intestinal epithelial cells had not ...
Olano José Miguel - - 2013
Tree-ring anatomy reflects the year-by-year impact of environmental factors on tree growth. Up to now, research in this field has mainly focused on the hydraulic architecture, with ray parenchyma neglected despite the growing recognition of its relevance for xylem function. Our aim was to address this gap by exploring the ...
Rego Eduardo M - - 2013
Modern treatment with all-trans retinoic acid (ATRA) and chemotherapy has converted acute promyelocytic leukemia (APL) into the most frequently curable leukemia. However, this progress has not yielded equivalent benefit to developing countries. The IC-APL was established to create a network in developing countries that would exchange experience and data and ...
Lindberg Daniel M - - 2013
OBJECTIVE:Routine testing of hepatic transaminases, amylase, and lipase has been recommended for all children evaluated for physical abuse, but rates of screening are widely variable, even among abuse specialists, and data for amylase and lipase testing are lacking. A previous study of screening in centers that endorsed routine transaminase screening ...
Bézier David - - 2013
B(C(6)F(5))(3) efficiently catalyzes hydrosilylation of aliphatic and aromatic carboxylic acids to produce disilyl acetals under mild conditions. Catalyst loadings can be as low as 0.05 mol %, and bulky tertiary silanes are favored to give selectively the acetals. Acidic workup of the disilyl acetals results in the formation of aldehydes ...
Stebbing J - - 2013
Claudins are integral structural and functional components of apical cell adhesions (tight junctions). Loss of such adhesions has been associated with malignant transformation, a process most often accompanied by a concomitant loss of claudin expression. A growing body of evidence reveals the highly contextual upregulation of claudin expression in certain ...
Nejia Herzi - - 2013
In this study, supercritical fluid extraction (SFE) with CO(2) and hydrodistillation (HD) were compared as methods to isolate the essential oil from Cupressus sempervirens. The odour of the oil obtained by SFE at 90 bar and 40°C was very close to the odour of the leaves of C. sempervirens before ...
Nomura Tadashi - - 2013
Vertebrate brains exhibit vast amounts of anatomical diversity. In particular, the elaborate and complex nervous system of amniotes is correlated with the size of their behavioral repertoire. However, the evolutionary mechanisms underlying species-specific brain morphogenesis remain elusive. In this review we introduce reptiles as a new model organism for understanding ...
Zara S - - 2013
Aims: The carotid body (CB) represents the prime site for detecting and responding to hypoxia. Since the role of heroin in respiratory depression with consequent hypoxia is known, the authors were able to investigate morphological and molecular modifications occurring in the CB of heroin addicted subjects compared to subjects who ...
Mistry Sandeep G - - 2013
Within the United Kingdom, a recent change in "Best Practice Guidance" has suggested that mammograms for symptomatic breast patients, with a clinically benign examination, should be limited to those over 40 years . This has led to anxiety over missing cancer diagnoses in the 35-39 year-old age group. This study aimed to ...
Etzold Sophia - - 2013
Stem CO(2) concentrations (stem [CO(2) ]) undergo large temporal variations that need to be understood to better link tree physiological processes to biosphere-atmosphere CO(2) exchange. During 19 months, stem [CO(2) ] was continuously measured in mature subalpine Norway spruce trees (Picea abies) and jointly analysed with stem, soil and air temperatures, ...
Waldmann Petra - - 2013
Exposure to radiofrequency (RF) electromagnetic fields (EMF) is continuously increasing worldwide. Yet, conflicting results of a possible genotoxic effect of RF EMF continue to be discussed. In the present study, a possible genotoxic effect of RF EMF (GSM, 1,800 MHz) in human lymphocytes was investigated by a collaboration of six ...
Kellett-Gregory Lindsay M - - 2013
OBJECTIVE: To describe the use of automated blood salvage devices for autotransfusion in dogs. TECHNIQUE: Blood salvage devices can be used to collect blood from the intraoperative surgical field or postsurgical drainage sites. The salvage device washes cells in 0.9% saline, removing plasma proteins, other cellular components, and activators of ...
Singhi Pratibha - - 2013
The opsoclonus-myoclonus syndrome is a distinct disorder characterized by opsoclonus, myoclonus, and ataxia, along with marked irritability and behavioral changes. Worldwide, data on its epidemiology, clinical features, and outcome are scarce. The aim of the study was to determine the clinical profile and outcome of children with this disorder. A ...
Bentley Adrienne M - - 2013
OBJECTIVE: To characterize derangements in the hemostatic profiles of dogs with naturally occurring septic peritonitis and determine if such derangements were predictive of survival. DESIGN: Prospective, observational single cohort study. SETTING: University veterinary teaching hospital. ANIMALS: A total of 27 client-owned dogs with naturally occurring septic peritonitis. INTERVENTIONS: Standard treatment ...
Inoue Hirofumi - - 2013
The therapeutic drug monitoring of paroxetine could be used to optimize the pharmacological treatment of depressed patients. A simple and sensitive high-performance liquid chromatography procedure was developed for the determination of paroxetine in serum. After simple pretreatment of serum (50 μL) with acetonitrile and o-phthalaldehyde, paroxetine was derivatized with 4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsulfonyl ...
Hrabok Marianne - - 2013
OBJECTIVES:The purpose of this paper was to investigate the contributions of sociodemographic, neurologic, and neuropsychological variables to health-related quality of life (HRQoL) in children with epilepsy and high seizure burden. Focus was placed on the relationship between memory and HRQoL, which has not been previously investigated.METHODS:Ninety children with epilepsy receiving ...
Souza Ana Cláudia - - 2013
ABSTRACT: BACKGROUND: There is an accumulating body of evidence indicating that neuronal functional specificity to basic sensory stimulation is mutable and subject to experience. Although fMRI experiments have investigated changes in brain activity after relative to before perceptual learning, brain activity during perceptual learning has not been explored. This work ...
Lee Janet T - - 2013
PURPOSE: Clostridium difficile infection (CDI) rates have been rising in recent years. We aimed to characterize CDI in lung transplant recipients in the modern era and hypothesized that CDI would increase the mortality risk. METHODS: We performed a retrospective chart review of patients undergoing transplantation at our center from 1/2006 ...
Solga A C - - 2013
Low-grade glial neoplasms (astrocytomas) represent one of the most common brain tumors in the pediatric population. These tumors frequently form in the optic pathway (optic pathway gliomas, OPGs), especially in children with the neurofibromatosis type 1 (NF1)-inherited tumor predisposition syndrome. To model these tumors in mice, we have previously developed ...
Jegaskanda Sinthujan - - 2013
A better understanding of immunity to influenza virus is needed to generate cross-protective vaccines. Engagement of Ab-dependent cellular cytotoxicity (ADCC) Abs by NK cells leads to killing of virus-infected cells and secretion of antiviral cytokines and chemokines. ADCC Abs may target more conserved influenza virus Ags compared with neutralizing Abs. ...
Shatnawei Abdullah - - 2013
Background: Intra-abdominal desmoid tumors (IADTs) are a common complication of familial adenomatous polyposis (FAP). Treatment is not standardized for advanced disease. Medical and surgical treatments may be ineffective in preventing complications, which can cause intestinal failure. Home parenteral nutrition (HPN) can be a life-saving treatment in these patients. The aim ...
Singh Vijay P - - 2013
Vitamin B6 is involved in a variety of enzymatic transformations. Some recent findings also indicate an antioxidant role of the Vitamin in biological systems. We set out to turn pyridoxine (1a) into a catalytic chain-breaking and hydroperoxide-decomposing antioxidant by replacing the 2-methyl substituent for an alkyltelluro group. Target molecules 12 ...
Liu X - - 2013
BACKGROUND: Neuroprotection from therapeutic hypothermia increases when combined with the anaesthetic gas xenon in animal studies. A clinical feasibility study of the combined treatment has been successfully undertaken in asphyxiated human term newborns. It is unknown whether xenon alone would be sufficient for sedation during hypothermia eliminating or reducing the ...
Stock Letícia - - 2013
Due to their remarkable roles in electrical cells signaling, voltage-gated cation channels (VGCCs) have been the subject of intense investigations and debate for over 50 years. Ultimately, the prospective implications of such studies imparts the understanding of VGCCs molecular properties involved in consciousness, anesthesia and diseases, to mention a few. ...
Stoica Mihaela V - - 2013
Bath salts are new designer drugs with stimulant effects on the central nervous system. White or brown powder sold online and in mini-marts under different brand names, bath salts can be used by injecting, snorting, smoking, or ingesting with food or drink. The case of a 30-year-old Caucasian male who ...
Noelken Robert - - 2013
BACKGROUND: Placement of implants into extraction sockets targets the maintenance of peri-implant hard and soft tissue structures and the support of a natural and esthetic contour. The main advantages of immediate implant insertion in comparison with delayed implant placement protocols are as follows: a reduced treatment time, less number of ...
Ho Rainbow T H - - 2013
Abstract Purpose: The aim of this review is to summarize and assess critically clinical trial evidence of the effect of t'ai chi (TC) exercise on immunity and TC efficacy for treating infectious diseases. Methods: Fourteen databases were searched from their respective inceptions through January 2011. No language restrictions were imposed. ...
Churchfield Matthew J - - 2013
This paper presents our initial work in performing large-eddy simulations of tidal turbine array flows. First, a horizontally periodic precursor simulation is performed to create turbulent flow data. Then those data are used as inflow into a tidal turbine array two rows deep and infinitely wide. The turbines are modelled ...
Huang Yufen - - 2013
To accelerate the drug development process and shorten approval time, the design of multiregional clinical trials (MRCTs) incorporates subjects from many countries/regions around the world under the same protocol. After showing the overall efficacy of a drug in all global regions, one can also simultaneously evaluate the possibility of applying ...
Seo Byung-Kwan - - 2013
ABSTRACT: BACKGROUND: Chronic non-specific low back pain is the most common medical problem for which patients seek complementary and alternative medical treatment, including bee venom acupuncture. However, the effectiveness and safety of such treatments have not been fully established by randomized clinical trials. The aim of this study is to ...
Li Zhe - - 2013
Zn(II) complexes of the following new, fluorine-containing, benzothiazole-derived ligands have been synthesized and characterized crystallographically: 2-(3,3,3-trifluoro-2-oxopropyl)benzothiazole (3), 4,5,6,7-tetrafluoro-2-(3,3,3-trifluoro-2-oxopropyl)benzothiazole (4), 4,5,6,7-tetrafluoro-2-(2-hydroxyphenyl)benzothiazole (12), 2-(3,4,5,6-tetrafluoro-2-hydroxyphenyl)-4,5,6,7-tetrafluorobenzothiazole (13), and 2-(3,4,5,6-tetrafluoro-2-hydroxyphenyl)benzothiazole (16); the Cu(II) complex of ligand 4 is also reported. These are analogs of the important photo- and electroluminescent material [Zn(BTZ)(2)](2), where H-BTZ = 2-(2-hydroxyphenyl)benzothiazole. ...
Fischer Benedikt - - 2013
PURPOSE: Prescription opioid analgesic (POA)-related burden of disease - including mortality - is high and constitutes a major public health problem in the US and Canada. Associations between the overall levels of POA consumption and key related morbidity indicators in the population have been demonstrated. We examined potential correlations between ...
Fidder Henk - - 2013
Dynamics and couplings of N-H stretching vibrations of chemically modified guanosine-cytidine (G•C) base pairs in chloroform are investigated with linear infrared spectroscopy and ultrafast two-dimensional infrared (2D-IR) spectroscopy. Comparison of G•C absorption spectra before and after H/D exchange reveals significant N-H stretching absorption in the region from 2500 up to ...
Naganathan Saranga - - 2013
We developed a general strategy to label expressed membrane proteins with a peptide-epitope tag and to detect the tagged proteins in native cellular membranes. First, we genetically encoded the unnatural amino acid, p-azido-L-phenylalanine (azF) at various specific sites in a G protein-coupled receptor (GPCR), C-C chemokine receptor 5 (CCR5). The ...
Itoi Toshiyuki - - 2013
BACKGROUND: The angiotensin type 2 (AT2)-receptor plays a unique role on growth inhibition in adult myocardium via modulation of ceramide synthesis. Angiotensin type 1 (AT1)-receptor blockade results in increased AT2-receptor activation by angiotensin II, and AT1-receptor blockers are sometimes prescribed to children for the treatment of cardiac hypertrophy or heart ...
Mohapatra Prasanta K - - 2013
Two new diglycolamide-based task-specific ionic liquids (DGATSILs) were evaluated for the extraction of actinides and lanthanides from acidic feed solutions. These DGATSILs were capable of exceptionally high extraction of trivalent actinide ions, such as Am(3+) , and even higher extraction of the lanthanide ion, Eu(3+) (about 5-10 fold). Dilution of the ...
Kim Dongeun - - 2013
Ir(I)-catalyzed enantioselective decarboxylative allylic etherification of aryl allyl carbonates provides aryl allyl ethers. Key to the generality and high stereoselection of the reaction is the use of the intramolecular decarboxylative allylation process and [Ir(dbcot)Cl](2) as an Ir(I) source. Ir(I)-catalyzed diastereoselective decarboxylative allylic etherification, combined with asymmetric aldehyde crotylation and cross ...
Gibbs Gerald V - - 2013
The bonded radii for more than 700 bonded pairs of atoms, comprising more than 50 oxide crystals, extracted from experimental and theoretical electron density distributions, are averaged and compared with the ionic radii for first, second and third row atoms. At odds with the assumption of a 'fixed' ionic radius ...
Erogbogbo Folarin - - 2013
We demonstrate that nanosize silicon (~10 nm diameter) reacts with water to generate hydrogen 10,000 times faster than bulk silicon, 100 times faster than previously reported Si structures and 6 times faster than competing metal formulations. The H2 production rate using 10 nm Si is 150 times that obtained using ...
Cabezas Carlos - - 2013
Microwave spectroscopy has been applied to characterize the conformations adopted in the gas phase by a small peptide derived from alanine, N-acetyl-l-alaninamide (Ac-Ala-NH(2)). This compound was vaporized by laser ablation and shown to exist as a mixture of C and C(5) conformers stabilized by a COHN intramolecular hydrogen bond closing ...
Poraty Limor - - 2013
How plants coordinate developmental processes and environmental stress responses is a pressing question. Here, we show that Arabidopsis AtROP6 integrates developmental and pathogen response signaling. AtROP6 expression is induced by auxin and detected in the root meristem, lateral root initials, and leaf hydathodes. Plants expressing a dominant negative AtROP6 (rop6DN) ...
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