Search Results
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Liu Liyu - - 2013
Metastasis, the truly lethal aspect of cancer, occurs when metastatic cancer cells in a tumor break through the basement membrane and penetrate the extracellular matrix. We show that MDA-MB-231 metastatic breast cancer cells cooperatively invade a 3D collagen matrix while following a glucose gradient. The invasion front of the cells ...
Gleason Nicholas J - - 2013
The ionization states of individual amino acid residues of membrane proteins are difficult to decipher or assign directly in the lipid-bilayer membrane environment. We address this issue for lysines and arginines in designed transmembrane helices. For lysines (but not arginines) at two locations within dioleoyl-phosphatidylcholine bilayer membranes, we measure pK(a) ...
Rhoades Charles C - - 2013
A current pine beetle infestation has caused extensive mortality of lodgepole pine (Pinus contorta) in forests of Colorado and Wyoming; it is part of an unprecedented multispecies beetle outbreak extending from Mexico to Canada. In United States and European watersheds, where atmospheric deposition of inorganic N is moderate to low ...
Chiu Yu-Chin - - 2013
Much research on response inhibition has focused on a consciously triggered variety (i.e., outright stopping of action). However, recent studies have shown that response inhibition can also be triggered unconsciously. For example, van Gaal, Ridderinkhof, Scholte, and Lamme (2010) showed that an unconscious no-go prime slowed down ongoing behavior, at ...
Catov Janet M JM Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. - - 2013
Preterm birth (PTB, <37 weeks) may be a marker of endothelial dysfunction and a proinflammatory phenotype; both are risk factors for cardiovascular disease. We studied 916 women (46% black) with 1181 live births between enrollment in the Coronary Artery Risk Development in Young Adults study (age 18-30 years) and 20 ...
Wu Weiwei - - 2013
During sleep, the brain network processes sensory stimuli without awareness. Stimulation must affect differently brain networks in sleep versus wake, but these differences have yet to be quantified. We recorded cortical activity in stage 2 (SII) sleep and wake using EEG while a tone was intermittently played. Zero-lag correlation measured ...
Little J L JL 1] Fox Chase Cancer Center, Institute of Cancer Research, Philadelphia, PA, USA [2] Department of Biology, Bryn Mawr College, Bryn Mawr, PA, - - 2014
Overexpression of the NEDD9/HEF1/Cas-L scaffolding protein is frequent, and drives invasion and metastasis in breast, head and neck, colorectal, melanoma, lung and other types of cancer. We have examined the consequences of genetic ablation of Nedd9 in the MMTV-HER2/ERBB2/neu mouse mammary tumor model. Unexpectedly, we found that only a limited ...
O'Mahen Heather - - 2013
BACKGROUND: Perinatal women with identified depression in prenatal care settings have low rates of engagement and adherence with depression-specific psychotherapy. We report the feasibility and symptom outcomes of Cognitive Behavioral Therapy (CBT) modified (mCBT) to address the needs of perinatal, low-income women with Major Depressive Disorder (MDD). METHODS: Pregnant women ...
Henning Susanne M SM Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. - - 2013
Tea polyphenols are metabolized by the colonic microflora yielding phenolic metabolites, which may contribute to the health benefits of tea. We determined the serum and urine concentrations of phenolic acids, hippuric acid, and polyhydroxyphenyl-γ-valerolactones during green tea (GT) and black tea (BT) administration. The effects of (-)-epigallocatechin gallate (EGCG) and ...
Tokuriki Shuko - - 2013
BACKGROUND: Biotin plays an important role as a covalently bound coenzyme for carboxylases. Carnitine is essential in β-oxidation to transport long-chain fatty acids across the inner mitochondrial membrane. The present study was conducted to assess the risk of biotin and carnitine deficiencies in preterm infants who received enteral feeding with ...
Eschenbrenner-Lux Vincent - - 2013
Cascade and domino reactions that proceed through multiple steps in one pot and include multiple bond formations are promising methods for the rapid and efficient generation of complex molecular architectures, including the scaffolds of classes of complex natural product. We describe the development of various one-pot cascade reaction sequences to ...
Simon Bernd - - 2013
This article examines the role of dual identity in political radicalism among migrants. Dual identity is defined as identification with both one's ethnocultural minority in-group and one's society of residence. We employed a longitudinal research design using members of the two largest migrant groups in Germany (Turkish migrants and Russian ...
Camp Jacqueline P JP Department of Psychology, University of Nevada, Las Vegas, - - 2013
The psychopathy checklist-revised (PCL-R; Hare, 1991, 2003) is often used to assess risk of violence, perhaps based on the assumption that it captures emotionally detached individuals who are driven to prey upon others. This study is designed to assess the relation between (a) core interpersonal and affective traits of psychopathy ...
Simon Manuel - - 2013
The epithelial cell adhesion molecule (EpCAM) is abundantly expressed in epithelial tumors, on cancer stem cells and circulating tumor cells. Together with its role in oncogenic signaling, this has sparked interest in its potential for tumor targeting with antibodies and drug conjugates for safe and effective cancer therapy. Recent advances ...
Lee Seungki - - 2013
The conservation of endangered fish is of critical importance. Cryobanking could provide an effective backup measure for use in conjunction with the conservation of natural populations; however, methodology for cryopreservation of fish eggs and embryos has not yet been developed. The present study established a methodology capable of deriving functional ...
Elchlepp Heike - - 2013
Brain-potential correlates of response conflict are well documented, but those of task conflict are not. Task-switching studies have suggested a plausible correlate of task conflict-a poststimulus posterior negativity-however, in such paradigms the negativity may also reflect poststimulus task-set reconfiguration postulated in some models. Here, participants alternated between single-task blocks of ...
Dettmer Ulf U Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, - - 2013
Aggregation of α-synuclein (αSyn) in neurons produces the hallmark cytopathology of Parkinson disease and related synucleinopathies. Since its discovery, αSyn has been thought to exist normally in cells as an unfolded monomer. We recently reported that αSyn can instead exist in cells as a helically folded tetramer that resists aggregation ...
Donohue Katelyn - - 2013
OBJECTIVE: To investigate differences in region-specific gray matter (GM) damage between adults with pediatric-onset (PO) multiple sclerosis (MS) and adult-onset (AO) MS. METHODS: Twenty-four relapsing-remitting (RR) adults with POMS (mean age = 35 years, mean disease duration = 18.4 years) were compared to 23 age-matched (AOA, mean age = 33.9 ...
Pérez-Núñez Ricardo - - 2013
Seatbelts and child restraints can reduce deaths resulting from road traffic crashes, and are one of the risk factors being targeted by the Road Safety in 10 Countries project in Mexico. This study quantifies the prevalence of restraint use in two of the intervention sites (Guadalajara-Zapopan and León) and one ...
Timmer M R - - 2013
Barrett's esophagus (BE) is the strongest risk factor for the development of esophageal adenocarcinoma. However, the risk of cancer progression is difficult to ascertain in individuals, as a significant number of patients with BE do not necessarily progress to esophageal adenocarcinoma. There are several issues with the current strategy of ...
Morito T - - 2013
The emergence of microalbuminuria following conditioning chemotherapy may predict the development of renal dysfunction. To confirm this, a 1-year retrospective cohort study was conducted in 31 myeloablative allogeneic SCT patients who received five consecutive measurements of albuminuria before conditioning therapy and on days 0, 7, 14 and 28 following SCT. ...
McIlhenny Stephen - - 2013
This study evaluates the durability of a novel tissue engineered blood vessel (TEBV) created by seeding a natural vascular tissue scaffold (decellularized human saphenous vein allograft) with autologous adipose-derived stem cells (ASC) differentiated into endothelial-like cells. Previous work with this model revealed the graft to be thrombogenic, likely due to ...
Gutierrez Jose - - 2013
BACKGROUND AND PURPOSE: Dolichoectasia (DE) is a vasculopathy that consists of abnormal elongation and dilatation of arteries. The objective of this study is to evaluate the frequency of DE in an unselected population and assess different diagnostic methods. METHODS: The Northern Manhattan Study is a multiethnic population based cohort of ...
Dörfler Florian - - 2013
The emergence of synchronization in a network of coupled oscillators is a fascinating topic in various scientific disciplines. A widely adopted model of a coupled oscillator network is characterized by a population of heterogeneous phase oscillators, a graph describing the interaction among them, and diffusive and sinusoidal coupling. It is ...
Wu Yuan-Ju - - 2013
Infection of newborn rats with Borne disease virus (BDV) results in selective degeneration of granule cell neurons of the dentate gyrus (DG). To study cellular countermechanisms that might prevent this pathology, we screened for rat strains resistant to this BDV-induced neuronal degeneration. To this end, we infected hippocampal slice cultures ...
Connolly Gregory C - - 2013
ABSTRACT: BACKGROUND: Diabetes mellitus (DM) is identified as a negative prognostic indicator in hepatocellular carcinoma (HCC), though the basis for this is unknown. METHODS: This is a retrospective analysis of a prospectively collected database of 191 HCC patients treated at the University of Rochester Medical Center (URMC) with orthotopic liver ...
Eickenberg Bernhard - - 2013
Under the influence of homogeneous, rotating magnetic fields, superparamagnetic beads can be assembled into one- and two-dimensional superstructures on demand and used as dynamic components in microfluidic systems for colloidal separation. In this paper, the influence of the magnetic field strength and the rotation frequency on the device efficiency is ...
Jackson Lisa A - - 2013
OBJECTIVE:Our objective was to assess whether the occurrence of medically attended local reactions to intramuscularly administered vaccines varies by injection site (arm versus thigh) in children 1 to 6 years of age.METHODS:This is a retrospective cohort study of children in the Vaccine Safety Datalink population from 2002 to 2009. Site ...
de Weerth Carolina C Montessorilaan 3, PO Box 9104, 6500 HE, Nijmegen, Netherlands. - - 2013
To provide a comprehensive analysis of the fecal microbiota in infants with colic, as compared with control infants, during their first 100 days of life. Microbial DNA of >200 samples from 12 infants with colic and 12 age-matched control infants was extracted and hybridized to a phylogenetic microarray. Microbiota diversity ...
Chauvin C - - 2013
S6 kinases (S6Ks) are mechanistic target of rapamycin substrates that participate in cell growth control. S6Ks phosphorylate ribosomal protein S6 (rpS6) and additional proteins involved in the translational machinery, although the functional roles of these modifications remain elusive. Here we analyze the S6K-dependent transcriptional and translational regulation of gene expression ...
Wu L L Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, - - 2014
Androgen receptor (AR) has essential roles during prostate cancer progression. With genome-wide AR-binding sites mapped to high resolution, studies have recently reported AR as a transcriptional repressor. How AR inhibits gene expression and how this contributes to prostate cancer, however, are incompletely understood. Through meta-analysis of microarray data, here we ...
Akarsu Saadet - - 2013
BACKGROUND: In this study the effects of the iron deficiency anemia (IDA) and its treatment on plasma total antioxidant capacity (TAOC) were investigated. METHODS: Eighty patients with IDA and the healthy control group form were divided into four subgroups as (oral [PO] group [n: 20], intramusculer [IM] group [n: 20], ...
Admiraal Wanda M - - 2013
Brown adipose tissue (BAT) has become a focus of research in the hope of finding a new target to fight obesity. Metabolic BAT activity can be visualized with (18)F-FDG PET/CT. Furthermore, the sympathetic innervation of BAT can be visualized with the radiolabeled norepinephrine analog (123)I-metaiodobenzylguanidine ((123)I-MIBG). We aimed to determine ...
Ko Eunkyung - - 2013
PURPOSE: This study was aimed at analyzing the recurrence-related prognostic significance of 12 candidate molecular biomarkers in node-negative stage I-II non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: We retrospectively analyzed promoter methylation of eight genes using methylation-specific PCR in formalin-fixed and paraffin-embedded tissues from 328 node-negative stage I-II NSCLCs. And, ...
Salthouse Timothy A TA Department of Psychology, University of Virginia, Charlottesville 22904, USA. - - 2013
It is widely accepted that the level of cognitive functioning can be influenced by characteristics of the environment that change over time. Many developmental researchers have referred to these influences as cohort effects, and have used year of birth as the basis for determining cohort membership. Furthermore, age-related differences in ...
Li Ao - - 2013
BackgroundMultimodal contrast agents usually containing two or more signal components can be used for several imaging modalities. Thus, complimentary information can be obtained by using just one kind of contrast agents.PurposeTo investigate the potential of superparamagnetic perfluorooctylbromide nanoparticles (M-PFOBNP) as a multimodal contrast agent for ultrasonography (US)/magnetic resonance (MR)/computed tomography ...
Keimpema Erik - - 2013
Endocannabinoid, particularly 2-arachidonoyl glycerol (2-AG), signaling has recently emerged as a molecular determinant of neuronal migration and synapse formation during cortical development. However, the cell type specificity and molecular regulation of spatially and temporally confined morphogenic 2-AG signals remain unexplored. Here, we demonstrate that genetic and pharmacological manipulation of CB(1) ...
Chomvarin Chariya C Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, - - 2013
Cholera, caused by Vibrio cholerae, results in significant morbidity and mortality worldwide, including Thailand. Representative V. cholerae strains associated with endemic cholera (n = 32), including strains (n = 3) from surface water sources, in Khon Kaen, Thailand (2003-2011), were subjected to microbiological, molecular and phylogenetic analyses. According to phenotypic ...
Jan Linda - - 2013
The mechanisms leading to the deposition of colloidal particles in a copper-gold galvanic microreactor are investigated. Using in situ current density measurements and particle velocimetry, we establish correlations between the spatial arrangement and the geometry of the electrodes, current density distribution, and particle aggregation behavior. Ionic transport phenomena are responsible ...
Singh Nikhlesh K NK Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, - - 2013
To understand the mechanisms of Src-PLD1-PKCγ-cPLA2 activation by vascular endothelial growth factor A (VEGFA), we studied the role of Kdr and Flt1. VEGFA, while having no effect on Flt1 phosphorylation, induced Kdr phosphorylation in human retinal microvascular endothelial cells (HRMVECs). Depletion of Kdr attenuated VEGFA-induced Src-PLD1-PKCγ-cPLA2 activation. Regardless of its ...
Daubersies Laure - - 2013
We engineered specific microfluidic devices based on the pervaporation of water through a PDMS membrane, to formulate continuous and steady concentration gradients of a binary aqueous molecular mixture at the nanolitre scale. In the case of a model complex fluid (a triblock copolymer solution), we demonstrate that such a steady ...
Broggi Julie - - 2013
The [Pd(SIPr)(PCy(3))] complex efficiently promotes a tandem process involving dehydrogenation of formic acid and hydrogenation of C-C multiple bonds using H(2) formed in situ. The isolation of a key catalytic hydridoformatopalladium species, [Pd{OC(O)H}(H)(IPr)(PCy(3))], is reported. The complex plays a key role in the Pd(0)-mediated formation of hydrogen from formic acid. ...
Jung Deokho - - 2013
Recently, significant advances have been made in live cell imaging owing to the rapid development of selective labeling of proteins in vivo. Green fluorescent protein (GFP) was the first example of fluorescent reporters genetically introduced to protein of interest (POI). While GFP and various types of engineered fluorescent proteins (FPs) ...
An Se-A - - 2013
ABSTRACT: BACKGROUND: Thrombolysis is strongly recommended for patients with significant neurologic deficits secondary to acute ischemic stroke. Extracranial bleeding is a rare but major complication of thrombolysis. CASE PRESENTATION: A 78-year-old woman presented with acute ischemic stroke caused by occlusion of the basilar artery. Clinical recovery was observed after successful ...
Guo Gang G Stanley Scott Cancer Center, Louisiana State University Medical Center, New Orleans, Louisiana, - - 2013
Inactivation of the tumor suppressor p53 through somatic mutations, observed in 50% of human cancers, is one of the leading causes of tumorigenesis. Clinical and experimental evidence also reveals that p53 mutations sometimes occur in tumor-associated fibroblasts, which correlate with an increased rate of metastases and poor prognosis, suggesting that ...
Oistämö Emma - - 2013
BackgroundBoth colon cancer and diverticular disease are common in the Western world. A challenge when patients present with clinical findings is that both diseases can present with symptoms that may mimic the other.PurposeTo determine whether magnetic resonance imaging (MRI) could be helpful to differentiate between diverticulitis and cancer of the ...
Ded Lukas - - 2013
Estrogens play a crucial role in spermatogenesis, and estrogen receptor alpha knock-out male mice are infertile. It has been demonstrated that estrogens significantly increase the speed of capacitation in vitro; however, this may lead to the reduction of reproductive potential due to the decreased ability of these sperm to undergo ...
Munich Stephan A - - 2013
Background The expanded endonasal endoscopic approach provides excellent visualization and access to midline skull base lesions, albeit with a relatively high risk of postoperative cerebrospinal fluid (CSF) leakage. We present our experience with the expanded endonasal endoscopic approach to the skull base in an institution where, previously, a traditional transsphenoidal approach ...
Smith Elizabeth S - - 2013
Unilateral nigrostriatal dopamine depletion in animals induces contralateral sensorimotor deficits that are like symptoms associated with Parkinson's disease (PD). Unilateral nigrostriatal dopamine depletion also causes a contralateral deficit in disengagement behavior (e.g., ability to stop an ongoing activity to orient/attend to a new stimulus). This disengagement deficit has been shown ...
Ding J - - 2013
Primary, small-cell esophageal carcinoma (SCEC) is a rare but highly malignant tumor. Due to lack of randomized, controlled, prospective studies, there are currently no unified treatment modalities for SCEC. This study retrospectively analyzed the outcomes of different treatments and prognostic factors that influence overall survival in patients with limited-stage SCEC. ...
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