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Pieragostino Damiana - - 2013
Transthyretin (TTR) is an homotetrameric protein of the Central Nervous System (CNS) that plays the role of the major Thyroxine (T4) carrier from blood to Cerebrospinal Fluid (CSF). T4 physiologically helps oligodendrocyte precursor cells to turn into myelinating oligodendrocytes, enhancing remyelination after myelin sheet damage. We investigated post-translational oxidative modifications ...
Cheewakriengkrai Laksanun - - 2013
Donepezil is the first cholinesterase inhibitor widely used for the treatment of Alzheimer's disease (AD). Its pharmacological actions are straightforward, enhancing cholinergic activity both in the brain and systemically, with a long-enough half-life to allow for once a day dosing. Its efficacy has been approved for use in mild-to-moderate AD ...
Vijayakumar Mahalingam R - - 2013
The major drawbacks associated with most of the anti-cancer drugs are their potential adverse effects. Distribution of these drugs throughout the body causes untoward adverse effects and less accumulation of drug at the site of tumors also causes decrease in therapeutic efficacy. Targeted nanomedicines are the emerging systems to improve ...
Hubbard Timothy L - - 2013
Memory for the initial pitch of an auditory target that increased or decreased in auditory frequency was examined. Memory was displaced forward in the direction of pitch motion, and this is consistent with the Fröhlich effect previously observed for visual targets moving in visual physical space. The Fröhlich effect for ...
Booth Jodie - - 2013
This paper aims to fill a gap in existing literature by using examples of reflective practice and how these informed service delivery and development with First Australians within a population health paradigm. Population-based approaches have been proposed as useful for providing services that reach beyond the individual. They may be ...
Rachmawati Rachmawati - - 2013
Several methods were used to investigate the possibility of preparing inclusion complexes between amylose and polytetrahydrofurans (PTHF) via direct mixing. Potato amylose (Mv ~200 kg/mol) and synthetic amylose (Mn 42 kg/mol) were complexed with PTHF having different molecular weights (Mn between 650-2900 kg/mol) to study the effect of the length ...
Beigi Maryam - - 2013
Asymmetric mixed carboligation reactions of α-ketoglutarate with different aldehydes were explored with the thiamine diphosphate dependent enzymes SucA from E. coli, Kgd from Mycobacterium tuberculosis, and MenD from E. coli. All three enzymes proved to be efficient biocatalysts to selectively deliver chiral δ-hydroxy-γ-keto acids with moderate to excellent stereoselectivity. The ...
Xu X-L - - 2013
E-cadherin is a 120-KD transmembrane calcium-dependent cell adhesion protein that has been demonstrated drownregulated in a large amount of invasive tumors. However, its effect on the prognosis of esophageal cancer (EC) remains controversial. All the relevant English articles that reported survival data or clinicopathological parameters were enrolled in this meta-analysis. ...
Goldsztein Hernan - - 2013
ObjectiveDescribe intraoperative facial nerve findings in 209 consecutive atresia cases. Identify preoperative and intraoperative anatomical variants that should alert the surgeon to potential high-risk facial nerve anatomy.Study DesignCase series with chart review.SettingTertiary care subspecialty private practice.MethodsRetrospective review of 209 consecutive atresia cases treated between 2007 and 2011. Descriptive analysis of ...
Yu Xiao-Feng - - 2013
Two series of ligand precursors [2-OH-3-(CH(2)NR(2))-5-MeC(6)H(2)](2)CH(2) (: NR(2) = NMe(2); : NR(2) = N(CH(2))(4); : NR(2) = N(CH(2))(5); : NR(2) = N(Me)Ph) and [2-OH-3-(CH[double bond, length as m-dash]NR)-5-MeC(6)H(2)](2)CH(2) (: R = 2,6-PrC(6)H(3); : R = p-MeC(6)H(4); : R = p-ClC(6)H(4); : R = p-MeOC(6)H(4); : R = Bu(t)) were prepared. ...
Su Wen-jing - - 2013
Large numbers of studies have focused on the posttranslational regulation of p53 activity. One of the best-known negative regulators for p53 is MDM2, an E3 ubiquitin ligase that promotes p53 degradation through proteasome degradation pathways. Additional E3 ligases have also been reported to negatively regulate p53. However, whether these E3 ...
Soumyanarayanan Anjan - - 2013
The competition between proximate electronic phases produces a complex phenomenology in strongly correlated systems. In particular, fluctuations associated with periodic charge or spin modulations, known as density waves, may lead to exotic superconductivity in several correlated materials. However, density waves have been difficult to isolate in the presence of chemical ...
Proctor Darby - - 2013
Is the sense of fairness uniquely human? Human reactions to reward division are often studied by means of the ultimatum game, in which both partners need to agree on a distribution for both to receive rewards. Humans typically offer generous portions of the reward to their partner, a tendency our ...
Zheng Weihua - - 2013
Frustration from strong interdomain interactions can make misfolding a more severe problem in multidomain proteins than in single-domain proteins. On the basis of bioinformatic surveys, it has been suggested that lowering the sequence identity between neighboring domains is one of nature's solutions to the multidomain misfolding problem. We investigate folding ...
Evans Tyler G - - 2013
Some marine ecosystems already experience natural declines in pH approximating those predicted with future anthropogenic ocean acidification (OA), the decline in seawater pH caused by the absorption of atmospheric CO(2) . The molecular mechanisms that allow organisms to inhabit these low pH environments, particularly those building calcium carbonate skeletons, are ...
Manktelow Bradley N BN Department of Health Sciences, University of Leicester, 22-28 Princess Rd West, Leicester LE1 6TP, United Kingdom. - - 2013
Estimates of the probability of survival of very preterm infants admitted to NICU care are vital for counseling parents, informing care, and planning services. In 1999, easy-to-use charts of survival according to gestation, birth weight, and gender were published in the United Kingdom. These charts are widely used in clinical ...
Martel Guillaume - - 2013
Abstract Background: Choledocholithiasis is a complex problem in patients with Roux-en-Y gastric bypass anatomy. Several techniques of biliary clearance have been described, but these can be limited by intra-abdominal adhesions. Patient and Methods: A 36-French surgical gastrostomy was created and was allowed to mature for 10 weeks. It was exchanged ...
Miura K - - 2013
Shp2 is a positive regulator for Erk activation downstream of receptor tyrosine kinases for growth factors. It has been controversial how Shp2 induces Erk activation. We here demonstrate that EphA2 is responsible for Shp2-mediated Erk activation by phosphorylating Tyr542 and Tyr580 of Shp2 in the cells stimulated with growth factors. ...
Lu Ganhua - - 2013
Interest in graphene has grown extensively in the last decade or so, because of its extraordinary physical properties, chemical tunability, and potential for various applications. However, graphene is intrinsically a semimetal with a zero bandgap, which considerably impedes its use in many applications where a suitable bandgap is required. The ...
Gong Hui - - 2013
PURPOSE: Constitutive activation of nuclear factor-κB (NF-κB) signaling plays vital roles in esophageal squamous cell carcinoma (ESCC) progression. The aim of this study was to evaluate the effect of miR-138 on NF-κB activation and ESCC progression. EXPERIMENTAL DESIGN: Expression of miR-138 in ESCC cell lines, ESCC tissues and 205 archived ...
Kuwahara Shunsuke - - 2013
Chirality transcription and amplification by the formation of chiral [2]pseudorotaxanes by an achiral crown ether having the 2',2''-quaterphenyl group and chiral sec-ammonium ions are reported. It was revealed that the absolute configurations of the chiral sec-ammonium ions can be detected directly from the CD spectra of the chiral [2]pseudorotaxanes.
Poddutoori Prashanth K - - 2013
Two self-assembled supramolecular donor-acceptor triads consisting of Al(III) porphyrin (AlPor) with axially bound naphthalenediimide (NDI) as an acceptor and tetrathiafulvalene (TTF) as a secondary donor are reported. In the triads, the NDI and TTF units are attached to Al(III) on opposite faces of the porphyrin, through covalent and coordination bonds, ...
Order Berndt-Michael - - 2013
BackgroundBreast cancer screening programs have been established worldwide and early detection of breast cancer has increased steadily. The most common way to confirm dignity of non-palpable and sonographically-occult suspicious findings on mammography is the stereotactically-guided vacuum-assisted breast biopsyPurposeTo compare two stereotactically guided vacuum-assisted breast biopsy systems measuring time effectiveness and ...
Sudo Noriko - - 2013
ABSTRACT: BACKGROUND: Focal ground-glass opacity (GGO) on thin-section computed tomography (CT) may be seen in atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ that has recently been renamed from bronchioloalveolar carcinoma (BAC) and various benign conditions. CASE PRESENTATION: We report a case of pulmonary focal fibrosis associated with microscopic arterio-venous fistula ...
Peirano Gisele - - 2013
The success of certain sequence types such as ST131 that produce CTX-Ms or NDMs and ST405 with CTX-Ms among extraintestinal E. coli (ExPEC) had previously been linked to a combination of antimicrobial resistance and certain virulence factors. The adherence properties of these sequence types to gastro-intestinal epithelial cells had not ...
Olano José Miguel - - 2013
Tree-ring anatomy reflects the year-by-year impact of environmental factors on tree growth. Up to now, research in this field has mainly focused on the hydraulic architecture, with ray parenchyma neglected despite the growing recognition of its relevance for xylem function. Our aim was to address this gap by exploring the ...
Rego Eduardo M - - 2013
Modern treatment with all-trans retinoic acid (ATRA) and chemotherapy has converted acute promyelocytic leukemia (APL) into the most frequently curable leukemia. However, this progress has not yielded equivalent benefit to developing countries. The IC-APL was established to create a network in developing countries that would exchange experience and data and ...
Lindberg Daniel M - - 2013
OBJECTIVE:Routine testing of hepatic transaminases, amylase, and lipase has been recommended for all children evaluated for physical abuse, but rates of screening are widely variable, even among abuse specialists, and data for amylase and lipase testing are lacking. A previous study of screening in centers that endorsed routine transaminase screening ...
Bézier David - - 2013
B(C(6)F(5))(3) efficiently catalyzes hydrosilylation of aliphatic and aromatic carboxylic acids to produce disilyl acetals under mild conditions. Catalyst loadings can be as low as 0.05 mol %, and bulky tertiary silanes are favored to give selectively the acetals. Acidic workup of the disilyl acetals results in the formation of aldehydes ...
Kuchenreuther M J MJ 1] BRIGHT Institute, Washington University School of Medicine, St Louis, MO, USA [2] Department of Internal Medicine, Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO, - - 2014
ARF is a multifunctional tumor suppressor that acts as both a sensor of oncogenic stimuli and as a key regulator of ribosome biogenesis. Recently, our group established the DEAD-box RNA helicase and microRNA (miRNA) microprocessor accessory subunit, DDX5, as a critical target of basal ARF function. To identify other molecular ...
Stebbing J - - 2013
Claudins are integral structural and functional components of apical cell adhesions (tight junctions). Loss of such adhesions has been associated with malignant transformation, a process most often accompanied by a concomitant loss of claudin expression. A growing body of evidence reveals the highly contextual upregulation of claudin expression in certain ...
Consul Claudio A - - 2013
This paper explores the influence of blockage and free-surface deformation on the hydrodynamic performance of a generic marine cross-flow turbine. Flows through a three-bladed turbine with solidity 0.125 are simulated at field-test blade Reynolds numbers, O(10(5)-10(6)), for three different cross-stream blockages: 12.5, 25 and 50 per cent. Two representations of ...
Sood Anjali - - 2013
Here we present novel hybrid inorganic-organic thin films of the (-Zn-O-C(6)H(4)-NH-)(n) type deposited in an atomic/molecular layer-by-layer manner through sequential gas-surface reactions of separately introduced inorganic (diethyl zinc) and organic (4-aminophenol) precursor pulses. The organic precursor employed is heterobifunctional (containing both hydroxyl and amino groups) and possesses a rigid benzene ...
Katagiri Seiichiro - - 2013
The Hedgehog signaling pathway is a key regulator of cell growth and differentiation during development. Whereas the Hedgehog pathway is inactive in most normal adult tissues, Hedgehog pathway reactivation has been implicated in the pathogenesis of several neoplasms including BCR-ABL1-positive leukemia. The clear link between the Hedgehog pathway and BCR-ABL1-positive ...
Andrikopoulos Prokopis C - - 2013
The role of framework oxygen atoms in N(2) O decomposition [N(2) O(g)→N(2) (g) and ${{{{1} \over {2}}}}$O(2) (g)] over Fe-ferrierite is investigated employing a combined experimental (N(2) (18) O decomposition in batch experiments followed by mass spectroscopy measurements) and theoretical (density functional theory calculations) approach. The occurrence of the isotope ...
Silvestri Romano - - 2013
Boger et al. synthesized a series of C20' urea derivatives of vinblastine that matched or exceeded the potency of vinblastine in cell growth inhibition assays. The studies demonstrated the importance of the H-bond donor on the C20' position and revealed the presence of a space surrounding the C20' substituent that ...
Bharathi M Jayahar MJ Department of Microbiology and Molecular Biology, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu 627 001, India. - - 2013
Microsporidia are obligate intracellular parasites that infect eukaryotic cells and have emerged as major opportunistic human pathogens. Due to the difficulties in definitive laboratory diagnosis and insufficient knowledge, ocular microsporidiosis is infrequently reported in India. To improve diagnostic facilities, we have developed a novel duplex PCR (dPCR) for the simultaneous ...
Nixon Carly - - 2013
We have carried out experiments to investigate the aging of latent fingerprints deposited on black PVC over a period of 4-15 weeks. A thumbprint was used in each case and before deposition of the print the donor rubbed their thumb around their nose to add sebaceous deposits. We have studied ...
Roman A - - 2013
BACKGROUND: The aim of this study was to evaluate whether the combination of enamel matrix derivative (EMD) with subepithelial connective tissue graft (SCTG) plus coronally advanced flap (CAF) would improve the treatment outcomes of Miller class I and II gingival recessions when compared with the same technique (SCTG plus CAF) ...
Park Tae Yeop - - 2013
BACKGROUND AND PURPOSE: Prostaglandin E(2) (PGE(2) ) has been implicated in the regulation of adhesion molecules, leukocyte adhesion and infiltration into inflamed site. However, the underlying mechanism therein involved remains ill-defined. In this study, we explored its cellular mechanism of action in the regulation of the intercellular adhesion molecule-1 (ICAM-1) ...
Kurotaki Daisuke D Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, - - 2013
Monocytes regulate host defenses, inflammation, and tissue homeostasis. The transcription factor interferon regulatory factor-8 (IRF8) stimulates monocyte/macrophage differentiation, yet genome-wide understanding of the differentiation program initiated by IRF8 is lacking. By combining chromatin immunoprecipitation sequencing with gene expression profiling, we show that during IRF8-dependent monocyte differentiation, IRF8 binding occurs at ...
McCormick Taylor - - 2013
The differential diagnosis for the infant presenting with an apparent life-threatening event (ALTE) is broad. Toxic ingestions are a relatively uncommon cause of an ALTE, although several over-the-counter, prescription, and illicit drugs have been implicated. We present 2 cases of ethanol intoxication in infants as a previously unreported cause of ...
Gordon Judith S JS Department of Family and Community Medicine, University of Arizona, 1450 E. Cherry Ave, Tucson, AZ 85719, USA. - - 2013
We report the results of a randomized clinical trial of a 3-hour, web-based, tobacco cessation education program, the Web-Based Respiratory Education About Tobacco and Health (WeBREATHe) program, for practicing pediatric respiratory therapists (RTs), registered nurses (RNs), and nurse practitioners (NPs). Two hundred fifteen RTs (n = 40), RNs (n = ...
Mathis Gérald - - 2013
2'-O-Neopentyldeoxyuridine (Un) was synthesized and incorporated into a series of oligodeoxyribonucleotides. Single and triple incorporations in various arrangements were performed. The Watson and Crick pairing properties with complementary DNA and RNA were investigated by UV melting curves, CD spectroscopy, and molecular dynamic simulations. The results were compared to those obtained ...
Andre Jo-Anne D - - 2013
The emphasis on scholarship in nursing, demands for evidence-based practice, and attention to writing have raised the profile of academic writing within nursing curricula. This article provides a comprehensive review of English and writing course requirements across 81 English-language baccalaureate nursing programs in Canada. The data were gathered from a ...
Fujita Shigeru - - 2013
ABSTRACT: BACKGROUND: Quality and safety issues are receiving growing attention. Patient safety culture (PSC) plays an important role in patient safety. The characteristics of PSC in various countries, each with a different set of values, have not been determined sufficiently. The aim of this study is to investigate the characteristics ...
Treno Andrew J AJ Pacific Institute for Research and Evaluation, Berkeley, CA 94704, USA. - - 2013
Alcohol beverage prices or taxes have been shown to be related to alcohol sales and use and related problems. What is not clear are the mechanisms underlying these relationships. This study examines the relationship between alcohol outlet density under conditions of the partial privatization of off-premise consumption in British Columbia ...
Jacoby George A - - 2013
qnr genes were discovered on plasmids by their ability to reduce quinolone susceptibility, but homologs can be found in the genomes of at least 92 Gram-negative, Gram-positive, and strictly anaerobic bacterial species. The related pentapeptide repeat protein-encoding mfpA gene is present in the genome of at least 19 species of ...
Belmonte Mark F - - 2013
Seeds are complex structures that consist of the embryo, endosperm, and seed-coat regions that are of different ontogenetic origins, and each region can be further divided into morphologically distinct subregions. Despite the importance of seeds for food, fiber, and fuel globally, little is known of the cellular processes that characterize ...
Akhavan-Sigari Reza - - 2013
Background Toxic epidermal necrolysis (TEN) is a rare, severe adverse drug reaction. Steven-Johnson syndrome (SJS) represents the milder end of the spectrum. The exact pathogenesis of TEN and SJS is still unknown. Many drugs, including prednisolone, cyclosporin, and intravenous immunoglobulin (IVIG), have been used in an attempt to halt the disease ...
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