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Grigorian Melina M Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, - - 2013
Hemocytes (blood cells) are motile cells that move throughout the extracellular space and that exist in all clades of the animal kingdom. Hemocytes play an important role in shaping the extracellular environment and in the immune response. Developmentally, hemocytes are closely related to the epithelial cells lining the vascular system ...
Tandon Rajendra R Sitaram Bhartia Institute of Science and Research, B-16, Mehrauli Institutional Area, New Delhi 110016, - - 2013
Rheumatic fever is one of the most-neglected ailments, and its pathogenesis remains poorly understood. The major thrust of research has been directed towards cross-reactivity between streptococcal M protein and myocardial α-helical coiled-coil proteins. M protein has also been the focus of vaccine development. The characteristic pathological findings suggest that the ...
Dieckmann Ralf R Department of Orthopaedics and Tumor Orthopaedics, Münster University Hospital, Albert-Schweitzer-Campus 1, A1, 48149, Münster, Germany. - - 2013
The functional results after reconstruction of the proximal humerus in tumour surgery are poor. Therefore, a reversed proximal humerus replacement was developed in our institution (MUTARS humerus inverse). A low degree of wear on the polyethylene is required because of the patients' youth and demands on shoulder function. A special ...
Sekiya Naosumi N Stem Cell Research Center, University of Pittsburgh, Pittsburgh, PA, - - 2013
Direct intracardiac cell injection for heart repair is hindered by numerous limitations including: cell death, poor spreading of the injected cells, arrhythmia, needle injury, etc. Tissue-engineered cell sheet implantation has the potential to overcome some of these limitations. We evaluated whether the transplantation of a muscle-derived stem cell (MDSC) sheet ...
Viel Thomas T Westfälische Wilhelms-Universität, Münster, Muenster, - - 2013
Despite treatments combining surgery, radiation-, and chemotherapy, patients affected by glioblastoma (GBM) have a limited prognosis. Addition of temozolomide (TMZ) to radiation therapy is the standard therapy in clinical application, but effectiveness of TMZ is limited by the tumor's overexpression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). The goal ...
Yonemitsu Yoshikazu Y Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. - - 2013
We here report the results of a Phase I/IIa open-label four dose-escalation clinical study assessing the safety, tolerability, and possible therapeutic efficacy of a single intramuscular administration of DVC1-0101, a new gene transfer vector based on a nontransmissible recombinant Sendai virus (rSeV) expressing the human fibroblast growth factor-2 (FGF-2) gene ...
Vozdova Miluse M Department of Genetics and Reproduction, Veterinary Research Institute, Hudcova 70, Brno, Czech Republic. - - 2013
To analyse relationships between semen parameters, sperm chromatin integrity and frequencies of chromosomally unbalanced, disomic and diploid sperm in 13 Robertsonian and 37 reciprocal translocation carriers and to compare the results with data from 10 control donors. Conventional semen analysis, Sperm Chromatin Structure Assay and FISH with probes for chromosomes ...
Heller Kristin N KN The Ohio State University, Columbus, OH, - - 2013
Duchenne muscular dystrophy (DMD) is a severe muscle disease caused by mutations in the DMD gene, with loss of its gene product, dystrophin. Dystrophin helps link integral membrane proteins to the actin cytoskeleton and stabilizes the sarcolemma during muscle activity. We investigated an alternative therapeutic approach to dystrophin replacement by ...
Rubenstein Joel H JH Center for Clinical Management Research, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan 48109, USA. - - 2013
Risk factors for Barrett's esophagus include gastroesophageal reflux disease (GERD) symptoms, age, abdominal obesity, and tobacco use. We aimed to develop a tool using these factors to predict the presence of Barrett's esophagus. Male colorectal cancer (CRC) screenees were recruited to undergo upper endoscopy, identifying newly diagnosed cases of Barrett's ...
Chan Simon S M SS Department of Medicine, Norwich Medical School, University of East Anglia, Norwich, UK. - - 2013
Obesity is associated with a proinflammatory state that may be involved in the etiology of inflammatory bowel disease (IBD), for which there are plausible biological mechanisms. Our aim was to perform the first prospective cohort study investigating if there is an association between obesity and the development of incident IBD. ...
Cassidy Aedín A Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, - - 2013
Our current knowledge of modifiable risk factors to prevent myocardial infarction (MI) in young and middle-aged women is limited, and the impact of diet is largely unknown. Dietary flavonoids exert potential beneficial effects on endothelial function in short-term trials; however, the relationship between habitual intake and risk of MI in ...
Khoo Tien K TK Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, - - 2013
Nonmotor symptoms (NMS) are common in patients with established Parkinson disease (PD) but their frequency in early PD has not been extensively studied. Our aim was to determine the frequency of NMS in a cohort of patients with newly diagnosed PD. A total of 159 patients with early PD and ...
Goto Yoshiyuki Y Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, - - 2013
Commensal bacteria regulate the homeostasis of host effector immune cell subsets. The mechanisms involved in this commensal-host crosstalk are not well understood. Intestinal epithelial cells (IECs) not only create a physical barrier between the commensals and immune cells in host tissues, but also facilitate interactions between them. Perturbations of epithelial ...
Otte Rik J RJ Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The - - 2013
Several studies have attributed deterioration of sound localization in the horizontal (azimuth) and vertical (elevation) planes to an age-related decline in binaural processing and high-frequency hearing loss (HFHL). The latter might underlie decreased elevation performance of older adults. However, as the pinnae keep growing throughout life, we hypothesized that larger ...
Skaliczki Gábor G Department of Orthopaedics, Semmelweis University, Karolina út 27, 1113, Budapest, Hungary. - - 2013
Blood-derived proliferative factors such as platelet rich plasma or activated plasma are promising adjuvants for bone grafts. Our earlier studies showed that serum albumin itself can markedly enhance the proliferation of stem cells on bone allograft and postulated that albumin coating alone may improve bone graft integration in vivo. Two ...
Zhou Yong Y Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, 610041, - - 2013
The aim of this study was to investigate the biomechanics of the pelvis reconstructed with a modular hemipelvic prosthesis using finite element (FE) analysis. A three-dimensional FE model of the postoperative pelvis was developed and input into the Abaqus FEA software version 6.7.1. Mesh refinement tests were then performed and ...
Shin Jin-Hong JH Department of Molecular Microbiology and Immunology, School of Medicine, The University of Missouri, Columbia, Missouri 65212, USA. - - 2013
Dystrophin deficiency results in lethal Duchenne muscular dystrophy (DMD). Substituting missing dystrophin with abbreviated microdystrophin has dramatically alleviated disease in mouse DMD models. Unfortunately, translation of microdystrophin therapy has been unsuccessful in dystrophic dogs, the only large mammalian model. Approximately 70% of the dystrophin-coding sequence is removed in microdystrophin. Intriguingly, ...
Williams Calvin B CB Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. - - 2013
The transcription factor Foxp3 plays an indispensible role in the differentiation of regulatory T (Treg) cells and the expression of their suppressive functions. In a recent article published in Nature, Ouyang et al. demonstrate that Treg cell differentiation is also enabled by transcriptional networks controlled by another Forkhead box family ...
Chen Dong D Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, - - 2013
Hepatocellular carcinoma (HCC) is a highly fatal disease mandating development of novel, targeted therapies to elicit prolonged survival benefit to the patients. Insulin-like growth factor-binding protein-7 (IGFBP7), a secreted protein belonging to the IGFBP family, functions as a potential tumor suppressor for HCC. In the present study, we evaluated the ...
Suzuki Masataka M Department of Molecular and Human Genetics, Baylor College of Medicine, Houston,Texas 77030, - - 2013
We previously dissected the components of the innate immune response to Helper-dependent adenoviral vectors (HDAds) using genetic models, and demonstrated that multiple pattern recognition receptor signaling pathways contribute to this host response to HDAds in vivo. Based on analysis of cytokine expression profiles, type I interferon (IFN) mRNA is induced ...
Kuzminov Andrei A Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. - - 2013
Simple DNA repeats (trinucleotide repeats, micro- and minisatellites) are prone to expansion/contraction via formation of secondary structures during DNA synthesis. Such structures both inhibit replication forks and create opportunities for template-primer slippage, making these repeats unstable. Certain aspects of simple repeat instability, however, suggest additional mechanisms of replication inhibition dependent ...
Pan A - - 2013
OBJECTIVE:To examine the long-term relationship between changes in water and beverage intake and weight change.SUBJECTS:Prospective cohort studies of 50 013 women aged 40-64 years in the Nurses' Health Study (NHS, 1986-2006), 52 987 women aged 27-44 years in the NHS II (1991-2007) and 21 988 men aged 40-64 years in the Health Professionals ...
Khan Akram A Oregon Health and Science University, Portland, OR 97239-3098, USA. - - 2013
Evaluate frequency of diagnostic testing for obstructive sleep apnea (OSA), prevalence of OSA, and factors independently associated with OSA status in adults undergoing bariatric surgery. DESIGN, SETTINGS AND INTERVENTIONS: Longitudinal Assessment of Bariatric Surgery-2 (LABS-2) is an observational cohort of 2,458 adults undergoing bariatric surgery at 10 U.S. hospitals. Within ...
Stöck M - - 2013
Contrasting with birds and mammals, most ectothermic vertebrates present homomorphic sex chromosomes, which might be due either to a high turnover rate or to occasional X-Y recombination. We tested these two hypotheses in a group of Palearctic green toads that diverged some 3.3 million years ago. Using sibship analyses of sex-linked ...
Sawatzky Jo-Ann V - - 2013
AIMS: To describe and compare the outcomes of a nurse practitioner-managed cardiac surgery follow-up model of care with the standard model of primary care provider follow-up for coronary artery bypass graft surgery patients. BACKGROUND: Advances in healthcare have had a favourable impact on length of stay following cardiac surgery; however, ...
Kawasaki Keitarou - - 2013
Chronic inflammation is an important contributor to the development and progression of metabolic syndrome. Recent evidence indicates that, in addition to innate immune cells, adaptive immune cells have an important role in this process. We previously showed that the serum level of B-cell-activating factor (BAFF) was increased in patients with ...
Alberti Giancarla - - 2013
New solid-phases for the binding, separation and extraction of perrhenate and pertechnetate (ReO(4)(-) and TcO(4)(-)) from water solutions have been developed from a selective molecular receptor. Host compounds being capable of encapsulating these oxoanions are of great interest. The azacryptand, containing two tripodal tetra-amine subunits covalently linked by p-xylyl spacers, ...
Wang Liang-Bing - - 2013
This communication reports a rational design of CaHPO4-α-amylase hybrid nanobiocatalytic system based on allosteric effect and an explanation of the increase in catalytic activity when certain enzymes are immobilized in specific nanomaterials. Employing a calcification approach in aqueous solutions, we acquired such new nanobiocatalytic systems with three different morphologies, i.e. ...
Pagano Silvia - - 2013
To investigate whether semantic information relative to numbers is retained during multiple object individuation, we recorded N2pc-a neural measure of selection/individuation-during a numerical version of the Stroop task. Participants enumerated a varying number of target digits (1 to 4) whose identity was either congruent or incongruent with their numerosity. N2pc ...
Efe Erkan - - 2013
The severe ischemia or necrosis of the glans penis is a rarely seen complication after circumcision. We report the case of a 7-year-old boy with severe glans penis ischemia occurring 24 hours after circumcision with local anesthesia (0.1% xylocaine containing ephedrine). His hemogram and levels of proteins C and S ...
Jin L - - 2013
Src is the founding member of a diverse family of intracellular tyrosine kinases, and Src has a key role in promoting cancer growth, in part, through its association with receptor tyrosine kinases. However, some Src-related proteins have widely divergent physiological roles, and these proteins include the Rak/Frk tyrosine kinase (Frk ...
Bahaj AbuBakr S - - 2013
Marine currents can carry large amounts of energy, largely driven by the tides, which are a consequence of the gravitational effects of the planetary motion of the Earth, the Moon and the Sun. Augmented flow velocities can be found where the underwater topography (bathymetry) in straits between islands and the ...
Ko Jean Y - - 2013
Introduction: Postpartum screening for glucose intolerance among women with recent histories of gestational diabetes mellitus (GDM) is important for identifying women with continued glucose intolerance after birth, yet screening rates are suboptimal. In a thorough review of the literature, we found no studies of screening practices among certified nurse-midwives (CNMs). ...
Casanova-Moreno Jannu R - - 2013
In-situ examination of the reductive desorption process for Au microelectrodes modified with a thiol self-assembled monolayer (SAM) using fluorescence microscopy enabled the study of the fate of the desorbed thiolate species. The Bodipy labelled alkyl-thiol SAM, when adsorbed, is not fluorescent due to quenching by the Au surface. Once reductively ...
Sankhe Shilpa - - 2013
BackgroundIntracerebral tuberculomas usually manifest as ring-enhancing of nodular lesions on magnetic resonance imaging (MRI). These imaging findings are also observed in other lesions like metastases and toxoplasmosis.PurposeTo study the MRI perfusion characteristics of tuberculomas and its potential role in their definitive diagnosis.Material and MethodsThirty-four tuberculomas were evaluated by conventional and ...
D'Argenio Alberto - - 2013
The international literature shows that in 40-50% of the cases, homicides-suicides involving children under the age of 10 are committed by mothers. Here, we report some results on homicides-suicides, in the mother-child relationship, occurred in Italy between 1992 and 2010. We examined 36 cases of filicide-suicide mothers by consulting the ...
De Poli Matteo - - 2013
Oligomers of the achiral amino acid Aib adopt helical conformations in which the screw-sense may be controlled by a single N-terminal residue. Using crystallographic and NMR techniques, we show that the left- or right-handed sense of helical induction arises from the nature of the beta-turn at the N terminus: the ...
Türkyılmaz Kemal - - 2013
Purpose: To compare peripapillary retinal nerve fiber layer (RNFL) thicknesses measured by Cirrus HD optical coherence tomography (OCT) of patients with vitamin B12 deficiency with healthy controls and to evaluate the correlation between the peripapillary RNFL thickness and plasma vitamin B12 levels. Materials and Methods: Forty-five patients (19 male and ...
Zhang Dongdi - - 2013
Two novel octamolybdate-based tricarbonyl metal derivatives have been successfully synthesized and characterized, which represent the first two examples of tricarbonyl metal groups attached to a new {Mo(8)O(30)} building block.
Itzykson Raphaël - - 2013
Genomic studies in chronic myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), and MPN/MDS, have identified common mutations in genes encoding signaling, epigenetic, transcription and splicing factors. In the present study, we interrogated the clonal architecture by mutation-specific discrimination analysis of single-cell-derived colonies in 28 patients with chronic myelomonocytic ...
Crosswhite Patrick - - 2013
Chronic exposure to cold caused pulmonary arterial hypertension (cold-induced pulmonary hypertension [CIPH]) and increased phosphodiesterase-1C (PDE-1C) expression in pulmonary arteries (PAs) in rats. The purpose of this study is to investigate a hypothesis that inhibition of PDE-1 would decrease inflammatory infiltrates and superoxide production leading to attenuation of CIPH. Three ...
Dethe Dattatraya H - - 2013
A novel approach was developed for the synthesis of highly substituted indene derivatives, using an FeCl(3) catalyzed Prins-type cyclization reaction which was further applied in the total synthesis of jungianol and epi-jungianol.
Wu J - - 2013
Malignant peripheral nerve sheath tumors (MPNSTs) develop sporadically or in the context of neurofibromatosis type 1. Epidermal growth factor receptor (EGFR) overexpression has been implicated in MPNST formation, but its precise role and relevant signaling pathways remain unknown. We found that EGFR overexpression promotes mouse neurofibroma transformation to aggressive MPNST ...
Ammoun S - - 2013
TAM family receptor tyrosine kinases comprising Tyro3 (Sky), Axl, and Mer are overexpressed in some cancers, correlate with multidrug resistance and contribute to tumourigenesis by regulating invasion, angiogenesis, cell survival and tumour growth. Mutations in the gene coding for a tumour suppressor merlin cause development of multiple tumours of the ...
Berggren Dusty Rose - - 2013
Results are presented from a chemostat study where the reductive dehalogenation of PCE was evaluated in the absence and presence of sulfate. Two chemostats inoculated with the Point Mugu culture, which contains strains of Dehalococcoides mccartyi, were operated at a 50 day HRT and fed PCE (12 mM) and lactate ...
Sloniec Jagoda - - 2013
Fluorescent derivatives of the (129) Xe NMR contrast agent cryptophane-A were obtained by functionalization with near infrared fluorescent dyes DY680 and DY682. The resulting conjugates were spectrally characterized, and their interaction with giant and large unilamellar vesicles of varying phospholipid composition was analyzed by fluorescence and NMR spectroscopy. In the ...
Long James Z - - 2013
The objective of this research is to determine whether there are significant differences in the (18)F-FDG produced by either the phosphate or the citrate buffer cassettes in the FASTlab synthesizer. METHODS: Forty batches of (18)F-FDG were produced with each cassette and analyzed retrospectively. The analysis consisted of determining the mean ...
McDonald Jennifer S - - 2013
Purpose:To perform a systematic review and meta-analysis of controlled studies examining the incidence of acute kidney injury (AKI) and other outcomes in patients exposed to intravenous (IV) contrast medium compared with patients who underwent an imaging examination without contrast medium or were otherwise unexposed (control group).Materials and Methods:MEDLINE, EMBASE, Scopus, ...
Schweickart Oliver - - 2013
How do people compare quantitative attributes of real-world objects? (e.g., Which country has the higher per capita GDP, Mauritania or Nepal?). The research literature on this question is divided: Although researchers in the 1970s and 1980s assumed that a 2-stage magnitude comparison process underlies these types of judgments (Banks, 1977), ...
Way Leilani Ireland - - 2013
OBJECTIVE: To determine the utility of performing urine Gram stain for detection of bacteriuria compared to routine urine sediment examination and bacterial aerobic urine culture. DESIGN: Prospective, observational study. SETTING: University teaching hospital. ANIMALS: Urine samples acquired via cystocentesis through convenience sampling from 103 dogs presenting to a tertiary referral ...
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