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Vozdova Miluse M Department of Genetics and Reproduction, Veterinary Research Institute, Hudcova 70, Brno, Czech Republic. - - 2013
To analyse relationships between semen parameters, sperm chromatin integrity and frequencies of chromosomally unbalanced, disomic and diploid sperm in 13 Robertsonian and 37 reciprocal translocation carriers and to compare the results with data from 10 control donors. Conventional semen analysis, Sperm Chromatin Structure Assay and FISH with probes for chromosomes ...
Chan Simon S M SS Department of Medicine, Norwich Medical School, University of East Anglia, Norwich, UK. - - 2013
Obesity is associated with a proinflammatory state that may be involved in the etiology of inflammatory bowel disease (IBD), for which there are plausible biological mechanisms. Our aim was to perform the first prospective cohort study investigating if there is an association between obesity and the development of incident IBD. ...
Cassidy Aedín A Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, - - 2013
Our current knowledge of modifiable risk factors to prevent myocardial infarction (MI) in young and middle-aged women is limited, and the impact of diet is largely unknown. Dietary flavonoids exert potential beneficial effects on endothelial function in short-term trials; however, the relationship between habitual intake and risk of MI in ...
Khoo Tien K TK Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, - - 2013
Nonmotor symptoms (NMS) are common in patients with established Parkinson disease (PD) but their frequency in early PD has not been extensively studied. Our aim was to determine the frequency of NMS in a cohort of patients with newly diagnosed PD. A total of 159 patients with early PD and ...
Goto Yoshiyuki Y Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, - - 2013
Commensal bacteria regulate the homeostasis of host effector immune cell subsets. The mechanisms involved in this commensal-host crosstalk are not well understood. Intestinal epithelial cells (IECs) not only create a physical barrier between the commensals and immune cells in host tissues, but also facilitate interactions between them. Perturbations of epithelial ...
Otte Rik J RJ Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The - - 2013
Several studies have attributed deterioration of sound localization in the horizontal (azimuth) and vertical (elevation) planes to an age-related decline in binaural processing and high-frequency hearing loss (HFHL). The latter might underlie decreased elevation performance of older adults. However, as the pinnae keep growing throughout life, we hypothesized that larger ...
Skaliczki Gábor G Department of Orthopaedics, Semmelweis University, Karolina út 27, 1113, Budapest, Hungary. - - 2013
Blood-derived proliferative factors such as platelet rich plasma or activated plasma are promising adjuvants for bone grafts. Our earlier studies showed that serum albumin itself can markedly enhance the proliferation of stem cells on bone allograft and postulated that albumin coating alone may improve bone graft integration in vivo. Two ...
Zhou Yong Y Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, 610041, - - 2013
The aim of this study was to investigate the biomechanics of the pelvis reconstructed with a modular hemipelvic prosthesis using finite element (FE) analysis. A three-dimensional FE model of the postoperative pelvis was developed and input into the Abaqus FEA software version 6.7.1. Mesh refinement tests were then performed and ...
Shin Jin-Hong JH Department of Molecular Microbiology and Immunology, School of Medicine, The University of Missouri, Columbia, Missouri 65212, USA. - - 2013
Dystrophin deficiency results in lethal Duchenne muscular dystrophy (DMD). Substituting missing dystrophin with abbreviated microdystrophin has dramatically alleviated disease in mouse DMD models. Unfortunately, translation of microdystrophin therapy has been unsuccessful in dystrophic dogs, the only large mammalian model. Approximately 70% of the dystrophin-coding sequence is removed in microdystrophin. Intriguingly, ...
Williams Calvin B CB Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. - - 2013
The transcription factor Foxp3 plays an indispensible role in the differentiation of regulatory T (Treg) cells and the expression of their suppressive functions. In a recent article published in Nature, Ouyang et al. demonstrate that Treg cell differentiation is also enabled by transcriptional networks controlled by another Forkhead box family ...
Chen Dong D Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, - - 2013
Hepatocellular carcinoma (HCC) is a highly fatal disease mandating development of novel, targeted therapies to elicit prolonged survival benefit to the patients. Insulin-like growth factor-binding protein-7 (IGFBP7), a secreted protein belonging to the IGFBP family, functions as a potential tumor suppressor for HCC. In the present study, we evaluated the ...
Suzuki Masataka M Department of Molecular and Human Genetics, Baylor College of Medicine, Houston,Texas 77030, - - 2013
We previously dissected the components of the innate immune response to Helper-dependent adenoviral vectors (HDAds) using genetic models, and demonstrated that multiple pattern recognition receptor signaling pathways contribute to this host response to HDAds in vivo. Based on analysis of cytokine expression profiles, type I interferon (IFN) mRNA is induced ...
Kuzminov Andrei A Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. - - 2013
Simple DNA repeats (trinucleotide repeats, micro- and minisatellites) are prone to expansion/contraction via formation of secondary structures during DNA synthesis. Such structures both inhibit replication forks and create opportunities for template-primer slippage, making these repeats unstable. Certain aspects of simple repeat instability, however, suggest additional mechanisms of replication inhibition dependent ...
Khan Akram A Oregon Health and Science University, Portland, OR 97239-3098, USA. - - 2013
Evaluate frequency of diagnostic testing for obstructive sleep apnea (OSA), prevalence of OSA, and factors independently associated with OSA status in adults undergoing bariatric surgery. DESIGN, SETTINGS AND INTERVENTIONS: Longitudinal Assessment of Bariatric Surgery-2 (LABS-2) is an observational cohort of 2,458 adults undergoing bariatric surgery at 10 U.S. hospitals. Within ...
Walensky Rochelle P RP Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2013
U.S. HIV treatment guidelines recommend branded once-daily, 1-pill efavirenz-emtricitabine-tenofovir as first-line antiretroviral therapy (ART). With the anticipated approval of generic efavirenz in the United States, a once-daily, 3-pill alternative (generic efavirenz, generic lamivudine, and tenofovir) will decrease cost but may reduce adherence and virologic suppression. To assess the clinical effect, ...
Karlström A A Department of Health Science, Mid Sweden University, Holmgatan 10, Sundsvall, Sweden. - - 2013
To compare maternal complications and infant outcomes for women undergoing elective caesarean sections based on a maternal request and without recorded medical indication with those of women who underwent spontaneous onset of labour with the intention to have a vaginal birth. Retrospective register study. Sweden; Medical Birth Register used for ...
Vivian Diana D Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, - - 2013
To synthesize a trifluorinated bile acid that can be used for (19)F magnetic resonance imaging (MRI) of bile acid enterohepatic circulation, characterize its in vitro transporter affinity, stability, and (19)F-MRI signal, and assess its ability to concentrate in the gallbladder of C57BL/6 mice. Target compound CA-lys-TFA was synthesized and tested ...
Anakwenze Oke A OA Department of Orthopaedic Surgery, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA. - - 2013
The factors that influence interest among medical students toward different medical specialties with time are important. The potential impact of changes in work-hour rules on orthopaedic applications in comparison to that of primary care medicine has not been reported. The change in number of applicants to general surgery during this ...
Roiko Samuel A SA Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical Sciences, State University of New York, Buffalo, Buffalo, New York 14214-8033, - - 2013
L-lactate represents a potential treatment for GHB overdose by inhibiting GHB renal reabsorption mediated by monocarboxylate transporters. Our objective was to assess the dose-dependence of L-lactate treatment, with and without D-mannitol, on GHB toxicokinetics/toxicodynamics (TK/TD). Rats were administered GHB 600 mg/kg i.v. with L-lactate (low and high doses), D-mannitol, or L-lactate ...
Restaino Odile Francesca OF Department of Experimental Medicine, Second University of Naples, Via De Crecchio 7, 80138 Naples, - - 2013
A bioengineered heparin, as a replacement for animal-derived heparin, is under development that relies on the fermentative production of heparosan by Escherichia coli K5 and its subsequent chemoenzymatic modification using biosynthetic enzymes. A critical enzyme in this pathway is the mammalian 6-O-sulfotransferase (6-OST-1) which specifically sulfonates the glucosamine residue in ...
Stroud Lynfa L Department of Medicine, University of Toronto, Toronto, Canada. - - 2013
Procedures form a core competency for internists, yet many do not master these skills during residency. Simulation can help fill this gap, but many curricula focus on technical skills, and overlook communication skills necessary to perform procedures proficiently. Hybrid simulation (HS) is a novel way to teach and assess procedural ...
Cox Ashley A Division of Urology, University of Toronto, Sunnybrook Health Sciences Centre, Room MG 408, 2075 Bayview Avenue, Toronto, ON M4N 3M5, - - 2013
Many surgical options exist for women with stress urinary incontinence (SUI). The traditional gold standards of Burch retropubic colposuspension and pubovaginal slings are still appropriate treatment options for some patients, but randomized controlled trials have demonstrated that synthetic midurethral slings are just as effective as these traditional procedures but with ...
Singh Manju Rawat MR University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), - - 2013
Wound is one of the oldest suffering associated with the mankind and its history is as old as humanity. Advances in the field of medical sciences created a pile of knowledge and paved the path for the development of a separate branch specifically devoted for wound healing. The understanding and ...
Rubenstein Joel H JH Center for Clinical Management Research, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan 48109, USA. - - 2013
Risk factors for Barrett's esophagus include gastroesophageal reflux disease (GERD) symptoms, age, abdominal obesity, and tobacco use. We aimed to develop a tool using these factors to predict the presence of Barrett's esophagus. Male colorectal cancer (CRC) screenees were recruited to undergo upper endoscopy, identifying newly diagnosed cases of Barrett's ...
Pavlovic Aleksandra M AM Neurology Clinic, Faculty of Medicine, University of Belgrade, Dr Subotica 6, 11000, Belgrade, Serbia. - - 2013
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common heritable cause of stroke and vascular dementia in adults. We present a family from Serbia presenting with stroke and depression in the lack of vascular risk factors, with brain MRI indicating CADASIL. A novel NOTCH3 Gly89Cys ...
Heller Kristin N KN The Ohio State University, Columbus, OH, - - 2013
Duchenne muscular dystrophy (DMD) is a severe muscle disease caused by mutations in the DMD gene, with loss of its gene product, dystrophin. Dystrophin helps link integral membrane proteins to the actin cytoskeleton and stabilizes the sarcolemma during muscle activity. We investigated an alternative therapeutic approach to dystrophin replacement by ...
Pan A A 1] Department of Nutrition, Harvard School of Public Health, Boston, MA, USA [2] Saw Swee Hock School of Public Health and Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Republic of - - 2013
To examine the long-term relationship between changes in water and beverage intake and weight change. Prospective cohort studies of 50013 women aged 40-64 years in the Nurses' Health Study (NHS, 1986-2006), 52987 women aged 27-44 years in the NHS II (1991-2007) and 21988 men aged 40-64 years in the Health ...
Lefkowitz Robert A RA Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. - - 2013
Myxofibrosarcoma frequently shows curvilinear extensions of high T2 signal that also enhance on magnetic resonance imaging; these "tails" represent fascial extension of tumor at histopathological examination. This study was performed to determine whether the tail sign is helpful in distinguishing myxofibrosarcoma from other myxoid-containing neoplasms. The study group consisted of ...
Rai M F MF Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes-Jewish Hospital, St Louis, MO, - - 2013
Aging and obesity contribute to the initiation and progression of osteoarthritis with little information on their relation to gene expression in joint tissues, particularly the meniscus. Here, we test the hypothesis that patient age and body mass index (BMI) correlate with the expression of osteoarthritis- and obesity-related gene signatures in ...
Maleki Nasim N P.A.I.N. Group, Department of Anesthesia, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. - - 2013
The majority of functional MRI studies of pain processing in the brain use the blood oxygenation level-dependent (BOLD) imaging approach. However, the BOLD signal is complex as it depends on simultaneous changes in blood flow, vascular volume and oxygen metabolism. Arterial spin labeling (ASL) perfusion imaging is another imaging approach ...
Jacques Paul F PF Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA. - - 2013
Evidence for cardioprotective effects of lycopene is inconsistent. Studies of circulating lycopene generally report inverse associations with CVD risk, but studies based on lycopene intake do not. The failure of dietary studies to support the findings based on biomarkers may be due in part to misclassification of lycopene intakes. To ...
Stöck M - - 2013
Contrasting with birds and mammals, most ectothermic vertebrates present homomorphic sex chromosomes, which might be due either to a high turnover rate or to occasional X-Y recombination. We tested these two hypotheses in a group of Palearctic green toads that diverged some 3.3 million years ago. Using sibship analyses of sex-linked ...
Sawatzky Jo-Ann V - - 2013
AIMS: To describe and compare the outcomes of a nurse practitioner-managed cardiac surgery follow-up model of care with the standard model of primary care provider follow-up for coronary artery bypass graft surgery patients. BACKGROUND: Advances in healthcare have had a favourable impact on length of stay following cardiac surgery; however, ...
Kawasaki Keitarou - - 2013
Chronic inflammation is an important contributor to the development and progression of metabolic syndrome. Recent evidence indicates that, in addition to innate immune cells, adaptive immune cells have an important role in this process. We previously showed that the serum level of B-cell-activating factor (BAFF) was increased in patients with ...
Alberti Giancarla - - 2013
New solid-phases for the binding, separation and extraction of perrhenate and pertechnetate (ReO(4)(-) and TcO(4)(-)) from water solutions have been developed from a selective molecular receptor. Host compounds being capable of encapsulating these oxoanions are of great interest. The azacryptand, containing two tripodal tetra-amine subunits covalently linked by p-xylyl spacers, ...
Wang Liang-Bing - - 2013
This communication reports a rational design of CaHPO4-α-amylase hybrid nanobiocatalytic system based on allosteric effect and an explanation of the increase in catalytic activity when certain enzymes are immobilized in specific nanomaterials. Employing a calcification approach in aqueous solutions, we acquired such new nanobiocatalytic systems with three different morphologies, i.e. ...
Pagano Silvia - - 2013
To investigate whether semantic information relative to numbers is retained during multiple object individuation, we recorded N2pc-a neural measure of selection/individuation-during a numerical version of the Stroop task. Participants enumerated a varying number of target digits (1 to 4) whose identity was either congruent or incongruent with their numerosity. N2pc ...
Efe Erkan - - 2013
The severe ischemia or necrosis of the glans penis is a rarely seen complication after circumcision. We report the case of a 7-year-old boy with severe glans penis ischemia occurring 24 hours after circumcision with local anesthesia (0.1% xylocaine containing ephedrine). His hemogram and levels of proteins C and S ...
Jin L - - 2013
Src is the founding member of a diverse family of intracellular tyrosine kinases, and Src has a key role in promoting cancer growth, in part, through its association with receptor tyrosine kinases. However, some Src-related proteins have widely divergent physiological roles, and these proteins include the Rak/Frk tyrosine kinase (Frk ...
Bahaj AbuBakr S - - 2013
Marine currents can carry large amounts of energy, largely driven by the tides, which are a consequence of the gravitational effects of the planetary motion of the Earth, the Moon and the Sun. Augmented flow velocities can be found where the underwater topography (bathymetry) in straits between islands and the ...
Ko Jean Y - - 2013
Introduction: Postpartum screening for glucose intolerance among women with recent histories of gestational diabetes mellitus (GDM) is important for identifying women with continued glucose intolerance after birth, yet screening rates are suboptimal. In a thorough review of the literature, we found no studies of screening practices among certified nurse-midwives (CNMs). ...
Casanova-Moreno Jannu R - - 2013
In-situ examination of the reductive desorption process for Au microelectrodes modified with a thiol self-assembled monolayer (SAM) using fluorescence microscopy enabled the study of the fate of the desorbed thiolate species. The Bodipy labelled alkyl-thiol SAM, when adsorbed, is not fluorescent due to quenching by the Au surface. Once reductively ...
Sankhe Shilpa - - 2013
BackgroundIntracerebral tuberculomas usually manifest as ring-enhancing of nodular lesions on magnetic resonance imaging (MRI). These imaging findings are also observed in other lesions like metastases and toxoplasmosis.PurposeTo study the MRI perfusion characteristics of tuberculomas and its potential role in their definitive diagnosis.Material and MethodsThirty-four tuberculomas were evaluated by conventional and ...
D'Argenio Alberto - - 2013
The international literature shows that in 40-50% of the cases, homicides-suicides involving children under the age of 10 are committed by mothers. Here, we report some results on homicides-suicides, in the mother-child relationship, occurred in Italy between 1992 and 2010. We examined 36 cases of filicide-suicide mothers by consulting the ...
De Poli Matteo - - 2013
Oligomers of the achiral amino acid Aib adopt helical conformations in which the screw-sense may be controlled by a single N-terminal residue. Using crystallographic and NMR techniques, we show that the left- or right-handed sense of helical induction arises from the nature of the beta-turn at the N terminus: the ...
Zhang Dongdi - - 2013
Two novel octamolybdate-based tricarbonyl metal derivatives have been successfully synthesized and characterized, which represent the first two examples of tricarbonyl metal groups attached to a new {Mo(8)O(30)} building block.
Itzykson Raphaël - - 2013
Genomic studies in chronic myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), and MPN/MDS, have identified common mutations in genes encoding signaling, epigenetic, transcription and splicing factors. In the present study, we interrogated the clonal architecture by mutation-specific discrimination analysis of single-cell-derived colonies in 28 patients with chronic myelomonocytic ...
Dethe Dattatraya H - - 2013
A novel approach was developed for the synthesis of highly substituted indene derivatives, using an FeCl(3) catalyzed Prins-type cyclization reaction which was further applied in the total synthesis of jungianol and epi-jungianol.
Wu J - - 2013
Malignant peripheral nerve sheath tumors (MPNSTs) develop sporadically or in the context of neurofibromatosis type 1. Epidermal growth factor receptor (EGFR) overexpression has been implicated in MPNST formation, but its precise role and relevant signaling pathways remain unknown. We found that EGFR overexpression promotes mouse neurofibroma transformation to aggressive MPNST ...
Ammoun S - - 2013
TAM family receptor tyrosine kinases comprising Tyro3 (Sky), Axl, and Mer are overexpressed in some cancers, correlate with multidrug resistance and contribute to tumourigenesis by regulating invasion, angiogenesis, cell survival and tumour growth. Mutations in the gene coding for a tumour suppressor merlin cause development of multiple tumours of the ...
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