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Results 401 - 450 of 4440
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Galvagnion C - - 2013
Mainly present in the mitochondria, the translocator protein, TSPO, previously known as the peripheral benzodiazepine receptor, is a small essential membrane protein, involved in the translocation of cholesterol across mitochondrial membranes, a rate determining step in steroids biosynthesis. We previously reported the structure of five fragments encompassing the five putative ...
Jour G - - 2013
Salivary gland tumors (SGT) are a heterogeneous group of lesions. There is conflicting data concerning the molecular events involving the tumour suppressor retinoblastoma protein (pRb) pathway in these tumors. Few studies examined the alterations in components of the Rb pathway by immunohistochemical (IHC) methods in benign and malignant SGTs. Furthermore, ...
Haas Michael - - 2013
PURPOSE: CA 19-9 is the only established tumor marker in pancreatic cancer (PC); the prognostic role of other serum markers like CEA, CRP, LDH or bilirubin has not yet been defined. METHODS: We pooled pre-treatment data on CA 19-9, CEA, CRP, LDH and bilirubin levels from two German multicenter randomized ...
Gadwala Mallikarjun - - 2013
The outstanding capability of two-dimensional gel electrophoresis in separating all types of proteins basically depends on the efficiency of sample preparation. Sample preparation is one of the most critical steps in two-dimensional gel electrophoresis. Unfortunately, due to severe solubility, resolution of protein on gel is usually hampered, and thus, analysis ...
Chaisakul Janeyuth - - 2013
Pre-synaptic PLA(2) neurotoxins are important components of many Australasian elapid snake venoms. These toxins disrupt neurotransmitter release. Taipoxin, a pre-synaptic neurotoxin isolated from the venom of the coastal taipan (Oxyuranus scutellatus), causes necrosis and muscle degeneration. The present study examined the myotoxic and cytotoxic activities of venoms from Papuan taipan ...
Guo Xun-Xiang - - 2013
The addition of o-halobenzoic acids to active internal alkynes proceeds efficiently in the presence of CuCl2 as a catalyst to give the corresponding isocoumarin derivatives in moderate to good yields. This strategy offers a simple efficient route to synthesis of the isocoumarin derivatives.
Ben-Mustapha Imen - - 2013
INTRODUCTION: Major histocompatibility complex class II (MHC-II) expression deficiency is a combined primary immunodeficiency leading to the impairment of the cellular and humoral immune responses. A majority of affected patients belong to consanguineous families particularly from the Maghreb, where a founder effect for a highly frequent mutation (named c.338-25_338del26) in ...
Jammi Suribabu - - 2013
Propargyl iodides are good precursors for allenylzincs via reaction with diethylzinc, even in non-degassed medium. These reactions proceed via zinc/iodine exchange. Owing to the previously reported detection of propargyl radical by ESR experiments in this process a radical mechanism was suspected. Calculations of the C-Zn BDEs in allenyl- and propargylzinc ...
Shinohara Hisashi - - 2013
We focused on the embryology and topographic anatomy of the infrapyloric lymph region, which is frequently involved in node metastases but technically complicated for dissection in gastric cancer surgery. Gastrointestinal organs possess their own mesenteries composed of double layers of peritoneum that enclose the intermediate adipose layer providing pathways for ...
Søndergaard Jens - - 2013
This study investigated dispersion and bioaccumulation of mining-related elements from an open-pit olivine mine at Seqi in Southwest Greenland (64° N) using lichens (Flavocetraria nivalis), seaweeds (Fucus vesiculosus), mussels (Mytilus edulis) and fish (Myoxocephalus scorpius). The mine operated between 2005 and 2009, and samples were taken every year within a monitoring ...
Yoshikawa Keiichi - - 2013
We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine ...
Zambriski Jennifer A - - 2013
The objective was to describe the probability of Cryptosporidium parvum fecal oocyst shedding at different magnitudes of exposure, the pattern of fecal shedding over time, and factors affecting fecal shedding in dairy calves. Within the first 24 h of life, 36 calves were experimentally challenged with C. parvum oocysts at one ...
Poley J - - 2013
Several immunostimulatory feed additives have shown the ability to induce protective responses in Atlantic salmon to infection with Lepeophtheirus salmonis. However, even the most encouraging results rarely surpass a 50% protective index in the host. That fact coupled with the well-documented limitations of single-therapy strategies in the effective management of ...
Yampolskaya Svetlana - - 2013
The goal of this study was to examine factors associated with time to first and subsequent readmissions of youth (N = 1,432) to one of Florida's residential mental health treatment programs, known as State Inpatient Psychiatric Program (SIPP). Results of multivariate Cox regression analysis indicated that greater maltreatment severity, shorter length of ...
de Novais Cândido Barreto - - 2013
Hyphal anastomoses which play a key role in the formation of interconnected mycorrhizal networks and in genetic exchange among compatible individuals have been studied in a limited number of species and isolates of arbuscular mycorrhizal fungi (AMF), mainly in symbiotic mycelium. In this work, the occurrence and frequency of anastomosis ...
Wei Shu-Qin - - 2013
Abstract OBJECTIVE: To estimate the associations between maternal vitamin D status and adverse pregnancy outcomes. STUDY DESIGN: We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to October, 2012 using the following keywords: 'vitamin D' and 'status' or 'deficiency' or 'insufficiency' and 'pregnancy'. ...
Kadam Abhijeet B - - 2013
PURPOSE: The purpose of the study was to propose a method of prone positioning for posterior cervico-dorsal spine surgeries that is easy to achieve without additional equipment and may reduce complications associated with prone positioning in patients. METHODS: 41 patients underwent posterior spine surgeries using our method of prone positioning ...
da Rocha Marilene L - - 2013
α,β-Epoxy-carvone (EC) is a monoterpene found in the essential oils of many species of plants. It can also be obtained by organic synthesis. EC exerts a depressant effect on the central nervous system and is also known to have anticonvulsant, antimicrobial and antioxidant effects. The present study investigated the antinociceptive ...
Berhouma Rym - - 2013
Our study aimed to analyze whether the expression of PPARγ mRNA in subcutaneous adipocyte tissue correlates with Pro12Ala PPARγ2 polymorphism in the obesity context. We found that mRNA expression of PPARγ in subcutaneous adipose tissue was greater in obese subjects (P < 0.05) than in the nonobese control group. Concurrently, genotyping of ...
Castro-Puyana María - - 2013
A novel experimental design was used to optimize the extraction of carotenoids from Neochloris oleoabundans using pressurized liquid extraction with food-grade solvents such as ethanol and limonene. Experimental factors, including the extraction temperature and the solvent composition, were optimized using a three-level factorial design. The response variables extraction yield and ...
Lachnit Tim - - 2013
The macroalga Fucus vesiculosus carries a specific community of surface bacteria. To identify chemical compounds that possibly mediate abundance and community composition of algae-associated bacteria, we tested the effect of surface-available algal compounds on bacterial settlement and community composition under field conditions. Compounds on algal thalli were separated from the ...
Matsuzawa Tomohiko - - 2013
Fission yeast flocculates non-sexually by induction of the flocculin encoded by gsf2(+) which is controlled by the positive regulator Mbx2. Here we report a novel gene designated gsf1(+) found to be a negative regulator of non-sexual flocculation. We identified gsf1(+) as a multicopy suppressor of a sam2 mutation, which caused ...
Byrnes John J - - 2013
RATIONALE: The use and misuse of prescription opiates in adolescent populations, and in particular, adolescent female populations, has increased dramatically in the past two decades. Given the significant role that opioids play in neuroendocrine function, exposure to opiates during this critical developmental period could have significant consequences for the female, ...
Hannemann A - - 2013
Research in the last decade has revealed that bone is not only a target tissue for numerous circulating hormones but functions as an endocrine organ itself. As a recent study demonstrated a stimulatory effect of the osteoblast-derived hormone osteocalcin (OCN) on testosterone production in mice, we investigated whether such an ...
Liu Feng - - 2013
BACKGROUND: To explore the predictive factors of cardiorespiratory abnormality in nonsedated patients at high altitude (HA) during upper gastrointestinal endoscopy (UGIE). METHODS: The pulse and saturated oxygen (SaO(2)) levels of 993 patients undergoing nonsedated UGIE in Tibet were monitored. Bivariate correlation and logistic regression were used to identify predictive risk ...
Isfort M - - 2013
In this article selected results of a descriptive study on personnel staffing and patient care in German intensive care units are presented and discussed. The main focus is on comparing features of personnel staffing with indicators of the job situation and patient care. The study is based on a standardized ...
Lv Yanni - - 2013
Nonmuscle myosin heavy chain IIA (NMMHC IIA, gene code: MYH9) plays a critical role in physiological and pathological functions. A homology model of NMMHC IIA was constructed based on the crystal structure of smooth muscle myosin II. Blebbistatin, a myosin II ATPase inhibitor, had been found to bind to NMMHC ...
Dygai A M - - 2013
The effects of nanotechnology (electron-beam) -PEGylated (or immobilized; Im) hyaluronidase (HD) on the state of the pool of bone marrow progenitor cells and their mobilization induced by granulocyte colony stimulating factor (G-CSF) were studied. A high specific activity of the drug Im-HD on progenitor cells of different classes was demonstrated ...
Trifa Fatma - - 2013
Aberrant methylation of the CpG islands in promoter regions is one of the mechanisms for inactivation of tumor suppressor genes in many human cancers including breast carcinoma. In this study, we aimed to assess, by methylation-specific PCR, the CpG methylation pattern of the UCHL1 promoter in 94 sporadic and 44 ...
Meng Yan-Yu - - 2013
A Gram-negative, aerobic, rod-shaped, motile, non-spore-forming bacterial strain, designated 13-Q(T), was isolated from seaside soil under the stacks of the red algae in Hainan province in China. Identification was carried out on the basis of polyphasic taxonomy. Phylogenetic analysis of 16S rRNA gene sequences showed that strain 13-Q(T) belonged to ...
Percival Kumiko A - - 2013
The roles of the midget and parasol pathways as the anatomical foundation for high-acuity vision at the fovea are well established. There is also evidence for the presence of other (non-midget, non-parasol) ganglion cell types in the foveal retina, but it is not established whether these cells receive input from ...
Kessous Roy - - 2013
Abstract Objective: To investigate whether a short interdelivery interval from cesarean section (CS) to a subsequent delivery is associated with adverse obstetric outcomes, and specifically uterine rupture. Study design: A retrospective study was conducted, comparing all patients who delivered following CS during the years 1988-2010. Time interval was defined as ...
Hughes Matthew - - 2013
A series of novel, highly substituted N-PMP aziridines have been accessed in high yields by palladium-catalyzed cross-coupling of intact aziridines. The cross-coupling employed aryl bromides and tertiary organometallic aziridines, generated from sulfinyl aziridines by sulfinyl-magnesium exchange and transmetallation to the aziridinyl-zinc with zinc chloride. A wide range of electron rich ...
Swapp Ryan E - - 2013
BACKGROUND: The purpose of this study was to determine whether surgical excision of benign solitary intraductal papillomas (BSIP) diagnosed by core needle biopsy (CNBx) without an associated high-risk lesion and concordant with imaging is justified. METHODS: A review of all papillary lesions diagnosed by CNBx from January 2003 to June ...
Bostani Arash - - 2013
ABSTRACT Aim: The aim of this randomized, double-blind, parallel-group study was to compare the efficacy and safety of low dose cinnarizine and sodium valproate in migraine prophylaxis. Methods: A total of 104 patients were treated during a 12-week treatment period. 25 mg Cinnarizine and 200 mg sodium valproate were administered every 12 hours. ...
Meimarakis Georgios - - 2013
BACKGROUND: The objective of this retrospective study was to assess the survival of patients after resection of hepatic and pulmonary colorectal metastases to identify predictors of long-term survival. METHODS: Patients receiving chemotherapy alone were compared to patients receiving surgery and chemotherapy in a matched-pair analysis with the following criteria: UICC ...
Stormoen M - - 2013
High mortality during the salmonid seawater phase is a continuous problem for the salmonid aquaculture industry, although the mortality levels show a large variation both in farms with a disease history and those without. We wanted to examine the mortality patterns in farms with pancreas disease (PD) and compare it ...
Hauser Ingrid - - 2013
Large-scale amine-based CO(2) capture will generate waste containing large amounts of ammonia, in addition to contaminants such as the actual amine as well as degradation products thereof. Monoethanolamine (MEA) has been a dominant amine applied so far in this context. This study reveals how biological N removal can be achieved ...
Ong Loke Meng - - 2013
AIM: The objective of the study was to compare the efficacy and safety of oral paricalcitol with oral calcitriol for treating secondary hyperparathyroidism. METHODS: We conducted the first multicenter open-labelled parallel group randomised controlled trial in 66 patients on dialysis. Patients were randomized to paricalcitol or calcitriol at a 3:1 ...
Marseille Elliot - - 2013
Abstract Objective: Gestational diabetes mellitus (GDM) is associated with elevated risks of perinatal complications and type 2 diabetes mellitus, and screening and intervention can reduce these risks. We quantified the cost, health impact, and cost-effectiveness of GDM screening and intervention in India and Israel, settings with contrasting epidemiologic and cost ...
Jasim Sina - - 2013
Abstract Granulomatous myopathy is an uncommon skeletal muscles disorder. It can develop in association with other granuloma-forming diseases and is then considered a secondary myopathy or, less frequently, a primary disorder for which no etiology is identified. Studies of granulomatous myopathies have focused on examining the differences between primary and ...
Manto Mario - - 2013
Although considerable progress has been made in developing models of cerebellar function in sensorimotor control, the exact nature of the basic operations performed by the cerebellum remain elusive. Several major theories have emerged these last decades. According to the hypothesis of Marr and Albus, the climbing fiber input carries an ...
Quirié Aurore - - 2013
Because arginase and nitric oxide (NO) synthases (NOS) compete to degrade l-arginine, arginase plays a crucial role in the modulation of NO production. Moreover, the arginase 1 isoform is a marker of M2 phenotype macrophages that play a key role in tissue remodeling and resolution of inflammation. While NO has ...
Schackert Gabriele - - 2013
BACKGROUND: Metastases are the most frequent tumours in the brain. At the time of diagnosis, more than 50% of patients present with multiple lesions. The goal of our retrospective investigation was to evaluate the outcome of patients who undergo surgery for multiple cerebral metastases and to determine prognostic factors. METHODS: ...
Forer Arthur - - 2013
Univalent sex chromosomes in crane-fly spermatocytes have kinetochore spindle fibres to each spindle pole (amphitelic orientation) from metaphase throughout anaphase. The univalents segregate in anaphase only after the autosomes approach the poles. As each univalent moves in anaphase, one spindle fibre shortens and the other spindle fibre elongates. To test ...
Hechtman Jaclyn Frances - - 2013
Pancreatic neuroendocrine tumors of the main pancreatic duct are rare and usually small due to symptoms of pancreatic duct obstruction. We present a case of a large (3 cm), well-differentiated (G1) lipid-rich polypoid neuroendocrine tumor of the pancreas completely occluding the main pancreatic duct with non-neoplastic-entrapped ductules and CK19 positivity. Clinical, ...
Alves Cresio - - 2013
INTRODUCTION: Hypothalamic hamartomas are very rare (1:200,000) and range in size from 17.9 to 18 mm. When their dimensions exceed 30-40 mm, they are classified as giant hypothalamic hamartomas. METHODS: We present a 14-month-old boy with central precocious puberty and gelastic seizures in whom a magnetic resonance imaging scan revealed a giant ...
Zheng Qi - - 2013
ABSTRACT: BACKGROUND: Gastric cancer is a common and highly lethal malignancy in the world, but its pathogenesis remains elusive. In this study, we focus on the biological functions of CDK-associated Cullin1 (CAC1), a novel gene of the cullin family, in gastric cancer, which may help us to further understand the ...
Farhath Sabeena - - 2013
Abstract: Objective: To study the relationship between pepsinogen/pepsin in a mouth swab and clinical gastroesophageal reflux (GER) in preterm infants. Methods: Preterm infants [birth weight (BW) ≤ 2000 grams] on full enteral feeds were enrolled. Mouth swabs from cheek and below the tongue were collected 1, 2 and 3 hours ...
Sun Xiaoyan - - 2013
Colloidal particles in water-lutidine (WL) binary liquid mixture experience temperature-dependent attraction close to the mixture's demixing temperature. This temperature-tunable interaction potentially can be harnessed to assemble colloids and grow colloidal crystals. In this paper, a novel attractive force gradient method, for the first time, is presented to fabricate high quality, ...
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