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Results 351 - 400 of 4440
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Chan Engle Angela - - 2013
AIM: To report a qualitative study which explores registered nurses' views on the issue of time in the workplace. BACKGROUND: There is a worldwide shortage of healthcare workers, subsequently time as a healthcare resource is both finite and scarce. As a result, increased attention is being paid to the restructuring ...
Adu Emmanuel K - - 2013
Eighteen (18) gravid uteri collected from hunters' kills during February and March 2008 were used to investigate growth and accretion of energy and protein in the gravid uterus during pregnancy in the grasscutter. Each gravid uterus was separated into foetal, placental, empty uterus and foetal fluids (amniotic and allantoic fluids ...
Bundred Nigel - - 2013
Olaparib (AZD2281) is an oral poly(ADP-ribose) polymerase (PARP) inhibitor with antitumour activity in cancer patients with BRCA1/2 germline mutations and in patients with homologous recombination deficiency. In this dose-finding study, patients were randomized to olaparib 10, 30, 100, 200 or 400 mg (capsule formulation) twice daily for the 4-5 days preceding breast ...
Kessous Roy - - 2013
Abstract Objective: To investigate whether a short interdelivery interval from cesarean section (CS) to a subsequent delivery is associated with adverse obstetric outcomes, and specifically uterine rupture. Study design: A retrospective study was conducted, comparing all patients who delivered following CS during the years 1988-2010. Time interval was defined as ...
Hughes Matthew - - 2013
A series of novel, highly substituted N-PMP aziridines have been accessed in high yields by palladium-catalyzed cross-coupling of intact aziridines. The cross-coupling employed aryl bromides and tertiary organometallic aziridines, generated from sulfinyl aziridines by sulfinyl-magnesium exchange and transmetallation to the aziridinyl-zinc with zinc chloride. A wide range of electron rich ...
Swapp Ryan E - - 2013
BACKGROUND: The purpose of this study was to determine whether surgical excision of benign solitary intraductal papillomas (BSIP) diagnosed by core needle biopsy (CNBx) without an associated high-risk lesion and concordant with imaging is justified. METHODS: A review of all papillary lesions diagnosed by CNBx from January 2003 to June ...
Bostani Arash - - 2013
ABSTRACT Aim: The aim of this randomized, double-blind, parallel-group study was to compare the efficacy and safety of low dose cinnarizine and sodium valproate in migraine prophylaxis. Methods: A total of 104 patients were treated during a 12-week treatment period. 25 mg Cinnarizine and 200 mg sodium valproate were administered every 12 hours. ...
Kornblum Cornelia C Department of Neurology, University of Bonn Medical Center, Bonn, - - 2013
Known disease mechanisms in mitochondrial DNA (mtDNA) maintenance disorders alter either the mitochondrial replication machinery (POLG, POLG2 and C10orf2) or the biosynthesis pathways of deoxyribonucleoside 5'-triphosphates for mtDNA synthesis. However, in many of these disorders, the underlying genetic defect has yet to be discovered. Here, we identify homozygous nonsense and ...
Meimarakis Georgios - - 2013
BACKGROUND: The objective of this retrospective study was to assess the survival of patients after resection of hepatic and pulmonary colorectal metastases to identify predictors of long-term survival. METHODS: Patients receiving chemotherapy alone were compared to patients receiving surgery and chemotherapy in a matched-pair analysis with the following criteria: UICC ...
Fraser William D - - 2013
Clinical interest in Vitamin D and its purported roles not only in calcium and bone metabolism but in several other medical conditions (diabetes, cardiovascular disease, multiple sclerosis, cancer, psychiatric disorders, neuro-muscular disease) has led to a surge in laboratory requests for 25 hydroxy vitamin D and 1,25 dihydroxy vitamin D ...
Luong Me-Linh - - 2013
Invasive aspergillosis (IA) is a major cause of morbidity and mortality in immunocompromised hosts. Economic expenditures prompted by this invasive fungal infection (IFI) are significant. Although, the duration and associated costs of hospitalization comprise the largest proportion of costs in large surveillance studies, the newer oral antifungal agents may impact ...
Jiao Rui Hua - - 2013
AIMS: This work was performed to characterize new secondary metabolites with neuraminidase inhibitory activity from marine actinomycete strains. METHODS AND RESULTS: An actinomycete strain IFB-A01, capable of producing new neuraminidase inhibitors, was isolated from the gut of shrimp Penasus orientalis and identified as Streptomyces seoulensis according to its 16S rRNA ...
Kontny Nina E - - 2013
PURPOSE: The aim of the current investigation was to develop a population pharmacokinetic model for doxorubicin and doxorubicinol that could provide improved estimated values for the pharmacokinetic parameters clearance of doxorubicin, volume of distribution of the central compartment, clearance of doxorubicinol and volume of distribution of the metabolite compartment for ...
Hsu Hsueh-Chuan - - 2013
Porous titanium and titanium alloys are promising scaffolds for bone tissue engineering, since they have the potential to provide new bone tissue ingrowth abilities and low elastic modulus to match that of natural bone. In the present study, porous Ti-7.5Mo alloy scaffolds with various porosities from 30 to 75 % ...
Timofeev Julia - - 2013
Abstract Objective: To examine the influence of maternal pre-pregnancy body mass index (BMI) on the rates of recurrent spontaneous preterm birth (SPTB) in women receiving 17α-hydroxyprogesterone caproate (17P). Methods: Retrospective analysis of a cohort of 6,253 women with a singleton gestation and prior SPTB enrolled in 17P home administration program ...
Aitken R J - - 2013
Oxidative stress is known to have a major impact on human sperm function and, as a result, there is a need to develop sensitive methods for measuring reactive oxygen species (ROS) generation by these cells. A variety of techniques have been developed for this purpose including chemiluminescence (luminol and lucigenin), ...
He Liang - - 2013
BACKGROUND: Matrix metalloproteinase-14 (MMP-14) has been considered to play an important role in invasion and metastasis of human solid tumor. AIM: The present study aimed to investigate the association of MMP-14 with overall survival in human gastric cancer. METHODS: Gastric cancer and adjacent normal specimens were collected from 205 patients ...
Rossi Giacomo - - 2013
Several studies of canine spontaneous mast cell tumours have described mutations in the c-kit proto-oncogene. These mutations produce a constitutively activated product and have been suggested to play a role in the malignant transformation of mast cells. We hypothesize that the selective tyrosine kinase inhibitor imatinib mesylate inhibits signal transduction ...
Brendel Bettina - - 2013
Friedreich ataxia (FRDA) is the most frequent recessive ataxia in the Western world. Dysarthria is a cardinal feature of FRDA, often leading to severe impairments in daily functioning, but its exact characteristics are only poorly understood so far. We performed a comprehensive evaluation of dysarthria severity and the profile of ...
Trifa Fatma - - 2013
Aberrant methylation of the CpG islands in promoter regions is one of the mechanisms for inactivation of tumor suppressor genes in many human cancers including breast carcinoma. In this study, we aimed to assess, by methylation-specific PCR, the CpG methylation pattern of the UCHL1 promoter in 94 sporadic and 44 ...
Meng Yan-Yu - - 2013
A Gram-negative, aerobic, rod-shaped, motile, non-spore-forming bacterial strain, designated 13-Q(T), was isolated from seaside soil under the stacks of the red algae in Hainan province in China. Identification was carried out on the basis of polyphasic taxonomy. Phylogenetic analysis of 16S rRNA gene sequences showed that strain 13-Q(T) belonged to ...
Percival Kumiko A - - 2013
The roles of the midget and parasol pathways as the anatomical foundation for high-acuity vision at the fovea are well established. There is also evidence for the presence of other (non-midget, non-parasol) ganglion cell types in the foveal retina, but it is not established whether these cells receive input from ...
Wu Ming - - 2013
Moesin, a member of the ERM family, acts as a linker between the actin cytoskeleton and the plasma membrane and plays a key role in the control of cell morphology, motility, adhesion and other processes of tumourigenesis. The expression pattern and clinical significance of moesin in astrocytoma remain unknown. In ...
Evangelinakis Nikolaos E - - 2013
Abstract Objective: Investigate changes in the cellular component of maternal immune system in a murine preterm delivery model. Methods: C57BL/6J mice were mated and on day 14.5 after plugging either whole blood was harvested or E.coli LPS was intraperitoneally injected. Preterm delivery resulted within 24hrs. 10-12hs after LPS injection (initiation ...
Xu Huipu - - 2013
This study aims to investigate the correlation between the different characteristics of plaques, plasma level of homocysteine (Hcy), and gene polymorphism of Hcy metabolism-related enzyme. In this consecutive case-control study, we measured the plasma Hcy level using fluorescence biochemistry method and examined the gene polymorphism of Hcy metabolism-related enzyme methylenetetrahydrofolate ...
Hashimoto Tatsuya - - 2013
BACKGROUND: Intramural metastasis (IM) in gastric cancer is rare. However, it often occurs with esophageal squamous cell carcinoma and has been reported to have a poor prognosis. METHODS: In 4,714 cases of gastric cancer that underwent gastrectomy, the clinicopathological features and postoperative prognoses of 29 cases with IM were evaluated ...
Gomez-Zorita Saioa - - 2013
Resveratrol is a naturally occurring polyphenol found in many dietary sources and red wine. Recognized as a cancer chemoprevention agent, an anti-inflammatory factor and an antioxidant molecule, resveratrol has been proposed as a potential anti-obesity compound and to be beneficial in diabetes. Most of the studies demonstrating the anti-adipogenic action ...
Oyetibo Ganiyu Oladunjoye - - 2013
Chromium (VI) [Cr (VI)] biosorption by four resistant autochthonous bacterial strains was investigated to determine their potential for use in sustainable marine water-pollution control. Maximum exchange between Cr (VI) ions and protons on the cells surfaces were at 30-35 °C, pH 2.0 and 350-450 mg/L. The bacterial strains effectively removed 79.0-90.5 % Cr (VI) ...
Nagaraju Mulpuri - - 2013
Human Cyclophilin A (CypA) catalyzes cis-trans isomerization of the prolyl peptide ω-bond in proteins and is involved in many sub-cellular processes. CypA has, therefore, been identified as a potential drug target in many diseases, and the development of potent inhibitors with high selectivity is a key objective. In computer-aided drug ...
Wallengren Ola - - 2013
PURPOSE: Cachexia is associated with adverse outcomes. There is limited information on the impact of different diagnostic criteria of cachexia on patient centered outcomes. METHODS: We compared the prevalence of reduced quality of life (QoL), physical function and survival in palliative care cancer patients classified by different cachexia criteria. Four ...
Zhang Ying - - 2013
Structural variation of the human genome sequence is the insertion, deletion, or rearrangement of stretches of DNA sequence sized from around 1,000 to millions of base pairs. Over the past few years, structural variation has been shown to be far more common in human genomes than previously thought. Very little ...
Hain Nicole - - 2013
Solid-supported lipid bilayers are used as cell membrane models and form the basis of biomimetic and biosensor platforms. The mechanism of their formation from adsorbed liposomes is not well-understood. Using membrane-permeable solute glycerol, impermeable solutes sucrose and dextran, and a pore forming peptide melittin, we studied experimentally how osmotic effects ...
Connor Erin E - - 2013
During weaning, epithelial cell function in the rumen transitions in response to conversion from a pre-ruminant to a true ruminant environment to ensure efficient nutrient absorption and metabolism. To identify gene networks affected by weaning in bovine rumen, Holstein bull calves were fed commercial milk replacer only (MRO) until 42 days ...
Masuda Toshiya - - 2013
Effects of various plant phenolics, including polyphenols, on the oxidation of oxymyoglobin were investigated. Most phenolics promoted the oxidation of oxymyoglobin at both pH 5.4 and 7.4. Potent oxidation-promoting activity was observed by several efficient antioxidant polyphenols with a catechol moiety. Therefore, effects of the catechol structure were investigated using ...
Grugni Graziano - - 2013
OBJECTIVE: A high prevalence (60%) of central adrenal insufficiency (CAI) has been reported in Prader-Willi syndrome (PWS) using the metyrapone test. We have assessed CAI in adults with PWS using the low-dose short synacthen test (LDSST). DESIGN: Basal cortisol and ACTH, and 30 minute cortisol after the administration of 1 ...
Lotti F - - 2013
Metabolic syndrome (MetS) is a diagnostic category which identifies subjects at high risk for diabetes and cardiovascular diseases, erectile dysfunction (ED) and male hypogonadism. However, MetS impact on male infertility has been poorly studied. We systematically evaluated possible associations between MetS and clinical characteristics in men with couple infertility. Out ...
Ko Je Yeong JY From the Department of Biological Science, Sookmyung Women's University, Seoul 140-742, Republic of - - 2013
Cilia in ciliated cells consist of protruding structures that sense mechanical and chemical signals from the extracellular environment. Cilia are assembled with variety molecules via a process known as intraflagellar transport (IFT). What controls the length of cilia in ciliated cells is critical to understand ciliary disease such as autosomal ...
Jammi Suribabu - - 2013
Propargyl iodides are good precursors for allenylzincs via reaction with diethylzinc, even in non-degassed medium. These reactions proceed via zinc/iodine exchange. Owing to the previously reported detection of propargyl radical by ESR experiments in this process a radical mechanism was suspected. Calculations of the C-Zn BDEs in allenyl- and propargylzinc ...
Bell Charlotte - - 2013
P-glycoprotein (Pgp) represents the archetypal mechanism of drug resistance. But Pgp alone cannot expel drugs. A small but growing body of works has demonstrated that the membrane biophysical properties are central to Pgp-mediated drug resistance. For example, a change in the membrane surface pressure is expected to support drug-Pgp interaction. ...
Shinohara Hisashi - - 2013
We focused on the embryology and topographic anatomy of the infrapyloric lymph region, which is frequently involved in node metastases but technically complicated for dissection in gastric cancer surgery. Gastrointestinal organs possess their own mesenteries composed of double layers of peritoneum that enclose the intermediate adipose layer providing pathways for ...
Søndergaard Jens - - 2013
This study investigated dispersion and bioaccumulation of mining-related elements from an open-pit olivine mine at Seqi in Southwest Greenland (64° N) using lichens (Flavocetraria nivalis), seaweeds (Fucus vesiculosus), mussels (Mytilus edulis) and fish (Myoxocephalus scorpius). The mine operated between 2005 and 2009, and samples were taken every year within a monitoring ...
Alves Cresio - - 2013
INTRODUCTION: Hypothalamic hamartomas are very rare (1:200,000) and range in size from 17.9 to 18 mm. When their dimensions exceed 30-40 mm, they are classified as giant hypothalamic hamartomas. METHODS: We present a 14-month-old boy with central precocious puberty and gelastic seizures in whom a magnetic resonance imaging scan revealed a giant ...
Childs Alexander S - - 2013
OBJECT: At high-field strengths (≥3T) inhomogeneity of the radio frequency (RF) field and RF power deposition become increasingly problematic. Parallel Transmission (PTx)-the use of segmented transmission arrays with independently driven elements-affords the ability to combat both of these issues. There are a variety of existing designs for PTx coils, ranging ...
Paquette Julie - - 2013
AIMS: To determine the effect of a nurse telephone follow-up on paediatric post-tonsillectomy pain intensity, complications, and use of other healthcare services. BACKGROUND: After tonsillectomy, children experience moderate-to-severe pain for days. Parents tend to give insufficient analgesia, with resulting increases in pain and postoperative complications. In adults, nurse telephone follow-up ...
Skilbrei O T - - 2013
The impact of salmon lice on the survival of migrating Atlantic salmon smolts was studied by comparing the adult returns of sea-ranched smolts treated for sea lice using emamectin benzoate or substance EX with untreated control groups in the River Dale in western Norway. A total of 143 500 smolts were ...
Shinoura Nobusada - - 2013
ABSTRACT The anatomic localization of brain functions can be characterized via diffusion tensor imaging (DTI) in patients with brain tumors and neurologic symptoms. The goal of the present study was to evaluate the function of the ventral, arcuate fasciculus (AF) and the superior longitudinal fasciculus (SLF)-related language pathways using these ...
Naderi Sahar - - 2013
Community-based interventions (CBI) have been targeted as a potential means of tackling cardiovascular disease in women. However, there have been mixed results in terms of their impact on health, with at least some of this being attributed to high attrition rates. This study explores factors that may be contributing to ...
Paerl Hans W - - 2013
Cyanobacteria are the Earth's oldest oxygenic photoautotrophs and have had major impacts on shaping its biosphere. Their long evolutionary history (∼3.5 by) has enabled them to adapt to geochemical and climatic changes, and more recently anthropogenic modifications of aquatic environments, including nutrient over-enrichment (eutrophication), water diversions, withdrawals, and salinization. Many ...
Poley J - - 2013
Several immunostimulatory feed additives have shown the ability to induce protective responses in Atlantic salmon to infection with Lepeophtheirus salmonis. However, even the most encouraging results rarely surpass a 50% protective index in the host. That fact coupled with the well-documented limitations of single-therapy strategies in the effective management of ...
Yampolskaya Svetlana - - 2013
The goal of this study was to examine factors associated with time to first and subsequent readmissions of youth (N = 1,432) to one of Florida's residential mental health treatment programs, known as State Inpatient Psychiatric Program (SIPP). Results of multivariate Cox regression analysis indicated that greater maltreatment severity, shorter length of ...
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