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Bianchi Giacomo - - 2013
We present a case of early degeneration of a bioprosthesis in the mitral position three years after implantation. Valve explantation revealed complete neo-intima formation and complete fusion of one commissure due to papillary muscle and chordae tendineae embedding in the bioprosthetic leaflets.
Trenholm Stuart - - 2013
Moving objects can cover large distances while they are processed by the eye, usually resulting in a spatially lagged retinal response. We identified a network of electrically coupled motion-coding neurons in mouse retina that act collectively to register the leading edges of moving objects at a nearly constant spatial location, ...
Ramos-Monroy O - - 2013
The main objective of this work was to evaluate the operational stability of a laboratory-scale aerobic biobarrier designed for the treatment of water contaminated by mixtures of three herbicides frequently found in agricultural runoffs, atrazine, simazine and 2,4-dichlorophenoxyacetic acid (2,4-D). The microbial consortium used to degrade the herbicides was composed ...
Chen Wei-Feng - - 2013
PURPOSE: Colorectal cancer is a common malignancy and one of the major causes of cancer-related deaths worldwide. Similar to other human cancers, tumor metastasis is the biggest obstacle in the clinical treatment of colorectal cancer. In this study, we explored the functional role of SLIT2 in colon tumor metastasis and ...
Scholte Ron H J - - 2013
Previous studies on victimization have either used self-reports of peer-reports, but correspondence between these measures is low, implying that types of victims may exist that differ in convergence between self- and peer-reported victimization. Importantly, the very few studies that do exist on such types were cross-sectional, and did not address ...
Lin Hao Daniel - - 2013
Hematopoietic stem cells (HSCs) from umbilical cord blood have been successfully used to treat blood disorders but one major hurdle is the relatively low cell dose available. Double cord blood unit transplantation results in elevated engraftment failure because one unit predominates over the other. Various approaches are thus being undertaken ...
Gerwick B Clifford - - 2013
A multiyear effort to identify new natural products was built on a hypothesis that both phytotoxins from plant pathogens and antimicrobial compounds might demonstrate herbicidal activity. The discovery of one such compound, mevalocidin, is described in the current report. Mevalocidin was discovered from static cultures of two unrelated fungal isolates ...
Dorantes Mendez Guadalupe - - 2013
The aim of this paper is to compare baroreflex sensitivity (BRS) following anesthesia induction via propofol to pre-induction baseline values through a systematic and mathematically robust analysis. Several mathematical methods for BRS quantification were applied to pre-operative and intra-operative data collected from patients undergoing major surgery, in order to track ...
Soares Giulliana Panfiglio - - 2013
This study evaluated the effect of polymerization mode and time and thermal and mechanical loading cycling (TMC) on microleakage in composite resin restorations. One hundred and eighty cavities were prepared and randomly divided according to the light curing time (20, 40, or 60 s), modes (quartz-tungsten-halogen (QTH)-420 mW/cm(2), LED 2 (2nd degree ...
Miyamoto Hirokuni - - 2013
AIMS: The oral administration of a compost produced by the fermentation of marine animals with thermophiles confers health benefits for fish and pigs. This study aimed to isolate the beneficial bacteria from this compost that would modulate the physiological conditions of host animals. METHODS AND RESULTS: The compost extract was ...
Prakash Dharmalingam - - 2013
Aluminum (Al) is an environmental neurotoxin that affects cerebral functions and causes health complications. However, the role of Al in arbitrating glia homeostasis and pathophysiology remains obscure. Astrocyte, microglia activation (reactive gliosis), and associated inflammatory events play a decisive role in neurodegeneration and may represent a target for treating neurodegenerative ...
Tang Xiaofeng - - 2013
In this study, we describe the quenching of electrochemiluminescence (ECL) of tris(2,2'-bipyridine)-ruthenium(II)(Ru(bpy)32+)/tri-n-propylamine(TPA) at pristine multiwall carbon nanotube (MWNT) modified glassy carbon (GC) electrode. Even that the faradic current of Ru(bpy)32+/TPA system and the oxidation of TPA obtained at pristine MWNT-modified GC electrode is enhanced compared with those at bare GC ...
Lee B-J - - 2013
Two consecutive studies were conducted to evaluate the dietary supplementation of citrus by-products (CB) fermented with probiotic bacteria on growth performance, feed utilization, innate immune responses and disease resistance of juvenile olive flounder. In Experiment I, five diets were formulated to contain 0% (control) or 3% four different CB fermented ...
Voutsas Ioannis F - - 2013
Abstract Purpose: Overexpression of human epidermal growth factor receptor-2 (HER-2/neu) in breast cancer patients is a prerequisite for treatment with trastuzumab. In the present study, we demonstrate by fluorescence in situ hybridization (FISH) analysis that HER-2/neu gene amplification and chromosome 17 (CEP17) polysomy can be induced by irradiation in human ...
Saghrouni Fatma - - 2013
Candida albicans is one of the most medically important fungi because of its high frequency as a commensal and pathogenic microorganism causing superficial as well as invasive infections. Strain typing and delineation of the species are essential for understanding its biology, epidemiology and population structure. A wide range of molecular ...
Jonusiene Violeta - - 2013
Notch signaling pathway is a highly conserved developmental pathway, which plays an important role in the regulation of cellular proliferation, differentiation and apoptosis. Deregulation of Notch pathway has been connected with the carcinogenesis in a variety of cancers. In this study, we investigated the expression of Notch receptors (NOTCH1, NOTCH2, ...
Buck Katharina - - 2013
Overexpression of CD24 has a negative impact on breast cancer prognosis. We have recently reported that the CD24 codon 57 Val/Val genotype (rs52812045) is associated with pathologic complete response after neoadjuvant chemotherapy for primary breast cancer and correlates with intratumoral lymphocyte infiltrates. This study was performed to investigate the influence ...
Pastuszak A W - - 2013
The question remains as to whether or not men would agree to posthumous sperm use for pregnancy initiation. Often, these individuals' lives are suddenly interrupted and prior consent is rarely given. Therefore, post-mortem retrieval or use of these spermatozoa remains controversial and the incidence of consent for post-mortem sperm use ...
Hietala K - - 2013
AIMS/HYPOTHESIS: This study aimed to investigate whether variation in long-term glycaemia in type 1 diabetes as measured by HbA(1c) variability is associated with the cumulative incidence and risk of retinopathy requiring laser treatment. METHODS: The effect of HbA(1c) variability was assessed in 2,019 Finnish Diabetic Nephropathy (FinnDiane) study patients. The ...
Thun Gian Andri - - 2013
Objective. The molecular mechanisms underlying the association between obesity (BMI ≥ 30 kg/m(2)) and asthma are poorly understood. Since shifts in the fate of bronchial cells due to low-grade systemic inflammation may provide a possible explanation, we investigated whether two of the best documented functional variants in cell cycle control genes modify the ...
Yanagawa Takao - - 2013
PURPOSE: Although erythropoietin (EPO) is known to express angiogenic and cardioprotective effects, it also induces hypertension, polycythemia, and platelet activation, which may cause serious adverse effects in patients with cardiovascular diseases. We compared the angiogenic effects of EPO and its nonerythropoietic derivative, asialo-EPO (AEPO). METHODS: Lower limb ischemia was induced ...
Lee Kyung-Hun - - 2013
PURPOSE: Ethnic diversity of genetic polymorphism can result in individual differences in the efficacy and toxicity of cancer chemotherapy. METHODS: We analyzed 20 germline polymorphisms in 10 genes (TS, MTHFR, ERCC1, XPD, XRCC1, ABCC2, AGXT, GSTP1, GSTT1 and GSTM1) from prospectively enrolled 292 Korean patients treated with adjuvant oxaliplatin plus ...
Mueller Monika - - 2013
Proteins like immunoglobulin (IgGs) are prone to degradation by a variety of pathways. In this study, a stabilizing formulation for long-term storage of a panel of seven monoclonal IgGs was found using differential scanning calorimetry (DSC). In the chosen formulations, the IgGs were subjected to stress, accelerated and real-time storage, ...
Humbeck Klaus - - 2013
Leaf senescence is regulated through a complex regulatory network triggered by internal and external signals for the reprogramming of gene expression. In plants, the major developmental phase transitions and stress responses are under epigenetic control. In this review, the underlying molecular mechanisms are briefly discussed and evidence is shown that ...
Shan Min - - 2013
The estrogen receptor (ER) is a hormone-regulated transcription factor that binds, as a dimer, to estrogens and to specific DNA sequences. To explore at a fundamental level the geometric and topological features of bivalent-ligand binding to the ER dimer, dimeric ER crystal structures were used to rationally design nonsteroidal bivalent ...
Krontiras Helen - - 2013
OPINION STATEMENT: Breast cancer is a complex, heterogeneous disease. Approximately 230,000 women are diagnosed with breast cancer in the United States each year and approximately 40,000 women die each year with breast cancer. Although prevention of the disease would be preferred, no real prospects are available in the near future ...
Ashkani S - - 2013
Malaysian rice, Pongsu Seribu 2, has wide-spectrum resistance against blast disease. Chromosomal locations conferring quantitative resistance were detected by linkage mapping with SSRs and quantitative trait locus (QTL) analysis. For the mapping population, 188 F(3) families were derived from a cross between the susceptible cultivar, Mahsuri, and a resistant variety, ...
Wu Ming - - 2013
Moesin, a member of the ERM family, acts as a linker between the actin cytoskeleton and the plasma membrane and plays a key role in the control of cell morphology, motility, adhesion and other processes of tumourigenesis. The expression pattern and clinical significance of moesin in astrocytoma remain unknown. In ...
Evangelinakis Nikolaos E - - 2013
Abstract Objective: Investigate changes in the cellular component of maternal immune system in a murine preterm delivery model. Methods: C57BL/6J mice were mated and on day 14.5 after plugging either whole blood was harvested or E.coli LPS was intraperitoneally injected. Preterm delivery resulted within 24hrs. 10-12hs after LPS injection (initiation ...
Xu Huipu - - 2013
This study aims to investigate the correlation between the different characteristics of plaques, plasma level of homocysteine (Hcy), and gene polymorphism of Hcy metabolism-related enzyme. In this consecutive case-control study, we measured the plasma Hcy level using fluorescence biochemistry method and examined the gene polymorphism of Hcy metabolism-related enzyme methylenetetrahydrofolate ...
Hashimoto Tatsuya - - 2013
BACKGROUND: Intramural metastasis (IM) in gastric cancer is rare. However, it often occurs with esophageal squamous cell carcinoma and has been reported to have a poor prognosis. METHODS: In 4,714 cases of gastric cancer that underwent gastrectomy, the clinicopathological features and postoperative prognoses of 29 cases with IM were evaluated ...
Gomez-Zorita Saioa - - 2013
Resveratrol is a naturally occurring polyphenol found in many dietary sources and red wine. Recognized as a cancer chemoprevention agent, an anti-inflammatory factor and an antioxidant molecule, resveratrol has been proposed as a potential anti-obesity compound and to be beneficial in diabetes. Most of the studies demonstrating the anti-adipogenic action ...
Oyetibo Ganiyu Oladunjoye - - 2013
Chromium (VI) [Cr (VI)] biosorption by four resistant autochthonous bacterial strains was investigated to determine their potential for use in sustainable marine water-pollution control. Maximum exchange between Cr (VI) ions and protons on the cells surfaces were at 30-35 °C, pH 2.0 and 350-450 mg/L. The bacterial strains effectively removed 79.0-90.5 % Cr (VI) ...
Iloro Ibon - - 2013
An access to fast and non-invasive techniques to infer or predict the drug-induced injury caused by newly developed drugs and to monitor therapeutic efficacy of established drugs during treatment are of the outmost importance in pharmaceutical industry and clinical diagnosis. Peptidome and low molecular weight proteome profiling is an emerging ...
Glendor Ulf - - 2013
BACKGROUND/AIM: The yearly cost of sports injuries, which affects Swedish society, is estimated to 3 billion SEK (460 million USD). Injuries in ice hockey represent at least 270 million SEK (42 million USD). Despite the high number of injuries, mouth and face guards are rarely used in Swedish ice hockey. The ...
Leisso Rachel - - 2013
The transition from cold storage to ambient temperature alters apple quality through accelerated softening, flavor and color changes, and development of physiological peel disorders, such as superficial scald, in susceptible cultivars. To reveal global metabolism associated with this transition, the 'Granny Smith' peel metabolome was evaluated during storage of 6 ...
Shi Jingchun - - 2013
Marine edible fish samples were collected from two important nearshore fishing sites in the eastern Guangdong Province, China: Shantou Harbor and Haimen Bay. In the mixed edible muscle tissues of marine fish samples, the concentrations of polychlorinated biphenyls, dichlorodiphenyltrichloroethanes (DDTs), hexachlorocyclohexanes (HCHs), chlordanes, and hexachlorobenzene ranged from 1.12 to 53.87, ...
Salgaonkar B B - - 2013
AIMS: Characterization of polyhydroxyalkanotes (PHA) accumulated by halophilic bacteria isolated from solar salterns. METHODS AND RESULTS: Twenty six halophilic isolates were obtained from solar salterns of Goa, India. They were screened for accumulation of PHA by Sudan black B, Nile blue A and Nile red stain. Strains H15, H16 and ...
Nagaraju Mulpuri - - 2013
Human Cyclophilin A (CypA) catalyzes cis-trans isomerization of the prolyl peptide ω-bond in proteins and is involved in many sub-cellular processes. CypA has, therefore, been identified as a potential drug target in many diseases, and the development of potent inhibitors with high selectivity is a key objective. In computer-aided drug ...
Wallengren Ola - - 2013
PURPOSE: Cachexia is associated with adverse outcomes. There is limited information on the impact of different diagnostic criteria of cachexia on patient centered outcomes. METHODS: We compared the prevalence of reduced quality of life (QoL), physical function and survival in palliative care cancer patients classified by different cachexia criteria. Four ...
Zhang Ying - - 2013
Structural variation of the human genome sequence is the insertion, deletion, or rearrangement of stretches of DNA sequence sized from around 1,000 to millions of base pairs. Over the past few years, structural variation has been shown to be far more common in human genomes than previously thought. Very little ...
Hain Nicole - - 2013
Solid-supported lipid bilayers are used as cell membrane models and form the basis of biomimetic and biosensor platforms. The mechanism of their formation from adsorbed liposomes is not well-understood. Using membrane-permeable solute glycerol, impermeable solutes sucrose and dextran, and a pore forming peptide melittin, we studied experimentally how osmotic effects ...
Connor Erin E - - 2013
During weaning, epithelial cell function in the rumen transitions in response to conversion from a pre-ruminant to a true ruminant environment to ensure efficient nutrient absorption and metabolism. To identify gene networks affected by weaning in bovine rumen, Holstein bull calves were fed commercial milk replacer only (MRO) until 42 days ...
Kim Eunkyoung - - 2013
Redox-cycling provides a mechanism to amplify electrochemical signals for analyte detection. Previous studies have shown that diverse mediators/shuttles can engage in redox-cycling reactions with a bio-based redox-capacitor that is fabricated by grafting redox-active catechols onto a chitosan film. Here, we report that redox-cycling with this catechol-chitosan redox-capacitor can amplify electrochemical ...
Guidotti Maurizio - - 2013
Selected polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) were detected by gas-chromatography coupled to triple quadrupole mass spectrometry (GC-QqQ-MS/MS) in marine sediments collected in central Italy. Total PCDD/Fs concentrations ranged from 11.58 to 193.29 pg/g d.w., with PCDFs as the major contributors in most cases. The congener profiles were characterized by high ...
Massas Ioannis - - 2013
The Thriassio plain is located 25 km west of Athens city, the capital of Greece. Two major towns (Elefsina and Aspropyrgos), heavy industry plants, medium to large-scale manufacturing, logistics plants, and agriculture comprise the main land uses of the studied area. The aim of the present study was to measure the ...
Song Jaeman - - 2013
We evaluated the impact of genetic variation in the prostate-specific antigen (PSA) gene (rs266882) on serum PSA levels in healthy men as well as risk factors for benign prostate hypertrophy (BPH) and prostate cancer. The study population comprised 91 men with PSA levels below 2.0 ng/ml as healthy controls, 78 men ...
Sahraei R - - 2013
In this paper, a new spectrophotometric method is reported for the determination of nanomolar levels of Eriochrome black T in environmental samples. The method is based on the catalytic effect of silver nanoparticles on the oxidation of Eriochrome black T by hexacyanoferrate (III) in acetate-acetic acid medium and at 25 °C. ...
Zhang Mingyang - - 2013
Cystathionine-β-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration. It was reported that CBS was a novel marker of both differentiation and proliferation for certain cell types, suggesting that CBS ...
Galvagnion C - - 2013
Mainly present in the mitochondria, the translocator protein, TSPO, previously known as the peripheral benzodiazepine receptor, is a small essential membrane protein, involved in the translocation of cholesterol across mitochondrial membranes, a rate determining step in steroids biosynthesis. We previously reported the structure of five fragments encompassing the five putative ...
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