Search Results
Results 101 - 150 of 4440
1 2 3 4 5 6 7 8 9 10 >
Brandt Roland - - 2013
Abstract Microcompartments are sub-organellar functional units and may have an important role in cellular physiology. They can act as highly dynamic or even transiently forming organizing compartments within cells. In this review, we would like to extend the concept of microcompartments as subcellular structures in individual cells in a way ...
Prevett Martin - - 2013
Over 10 million people in Africa have epilepsy of which most have no access to appropriate treatment. Epilepsy in Africa is different- the incidence is higher, and the causes and cultural attitudes towards it differ. This article examines the epidemiology, causes and treatment of epilepsy in sub-Saharan Africa and looks ...
Candido Kenneth D - - 2013
Cervical epidural steroid injections (CESI) are an accepted treatment for neck pain with a radicular component, and may be accomplished by using either transforaminal (CTFESI) or interlaminar (CILESI) approaches. CESIs are routinely performed using real-time fluoroscopic-guidance in conjunction with the injection of water soluble, iodine-based contrast media to enhance visualization ...
Gondi Vinai - - 2013
To prospectively evaluate the association between hippocampal dose and long-term neurocognitive function (NCF) impairment for benign or low-grade adult brain tumors treated with fractionated stereotactic radiotherapy (FSRT). Adult patients with benign or low-grade adult brain tumors were treated with FSRT per institutional practice. No attempt was made to spare the ...
Kluger Nicolas - - 2013
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) (or autoimmune polyendocrine syndrome type 1) is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator gene. It causes a loss in central immune tolerance, failure to eliminate autoreactive T cells in the thymus, and their escape to the periphery. APECED patients are ...
Bagdasarov Zhanna - - 2013
We investigated the role of anger expression and cultural framework in predicting Russian immigrant women's physical and psychological health status. One hundred Russian immigrant women between the ages of 30 and 65 completed questionnaires assessing anger expression, cultural framework, and health status. All research questions were addressed using hierarchical regression ...
Caravagna Giulio - - 2013
A tumor is kinetically characterized by the presence of multiple spatio-temporal scales in which its cells interplay with, for instance, endothelial cells or Immune system effectors, exchanging various chemical signals. By its nature, tumor growth is an ideal object of hybrid modeling where discrete stochastic processes model low-numbers entities, and ...
Kuppinger David - - 2013
The Nutritional Risk Screening-2002 (NRS-2000) is currently recommended by the European Society of Parenteral and Enteral Nutrition as a screening tool in hospitalized patients. However, for preoperative risk prediction, the usefulness of this tool is uncertain and may depend on the type of surgical disease. The present study investigated the ...
Clarke Collin F M - - 2013
Functional imaging of the central nervous system has been utilized since the 1970s focusing on the concept that neural functioning is coupled to regional cerebral blood flow. This has allowed for extensive mapping of the neural pathways associated with pain, the "pain-matrix." The study of the functional anatomy utilizes positron ...
Congly Stephen E - - 2013
Portal vein thrombosis (PVT) can contribute to significant morbidity and mortality; in patients with cirrhosis, this can make transplant more technically challenging. Additionally, the clot may extend further into the mesenteric and splenic veins, and disturbance of the hepatic blood flow may lead to faster progression of the cirrhosis. Development ...
Lignet Floriane - - 2013
The vascular endothelial growth factor (VEGF) is known as one of the main promoter of angiogenesis - the process of blood vessel formation. Angiogenesis has been recognized as a key stage for cancer development and metastasis. In this paper, we propose a structural model of the main molecular pathways involved ...
Byrne Eilish - - 2013
ABSTRACT This article presents the elements of the Intervention section of the Infant Care Path for Physical Therapy in the Neonatal Intensive Care Unit (NICU). The types of physical therapy interventions presented in this path are evidence-based and the suggested timing of these interventions is primarily based on practice knowledge ...
Yoshioka Yukio - - 2013
The objective of this study was to investigate the histogenesis of ectomesenchymal chondromyxoid tumors (ECTs) of the tongue. The biochemical characteristics of a rarely occurring tumor of the tongue were analyzed by immunohistochemistry and reverse-transcriptase polymerase chain reaction (RT-PCR), and its biological properties were assessed in primary culture in serum-free ...
Carinci Adam J - - 2013
Chronic pelvic pain (CPP) is a significant clinical entity that affects both men and women alike. The etiologies of CPP are multifactorial, and treatments are myriad. Complementary and Alternative Medicine (CAM) refers to non-allopathic health systems, and its use is popular in the United States. In particular, several recent studies ...
d'Onofrio Alberto - - 2013
There is an increasing awareness that to properly understand how tumors originate and grow, and then how to develop effective cures, it must be taken into account the dynamics of tumors and its great complexity. Tumors are characterized not only by the coexistence of multiple scales, both temporal and spatial, ...
Guermazi Ali - - 2013
Osteoarthritis (OA) is the most prevalent joint disorder in the elderly, and there is no effective treatment. Imaging is essential for evaluating the synovial joint structures (including cartilage, meniscus, subchondral bone marrow and synovium) for diagnosis, prognosis, and follow-up. This article describes the roles and limitations of both conventional radiography ...
Smecuol Edgardo - - 2013
: The aim of this exploratory trial was to establish if the probiotic Bifidobacterium natren life start (NLS) strain strain may affect the clinical course and pathophysiological features of patients with untreated celiac disease (CD). Positive findings would be helpful in directing future studies. : Twenty-two adult patients having 2 ...
Mumford Colin J - - 2013
Medicolegal work is a mystery to most neurologists. What does it involve? What does the beginner medical expert need to know? Should barristers be feared? This article provides some of the answers.
Criaco D - - 2013
In a previous paper a mathematical model was developed for the dynamics of activation and clonal expansion of T cells during the immune response to a single type of antigen challenge, constructed phenomenologically in the macroscopic framework of a thermodynamic theory of continuum mechanics for reacting and proliferating fluid mixtures. ...
Vyncke Krishna E - - 2013
The present study assessed whether compliance with the Food-Based Dietary Guidelines is related to habitual fatty acid (FA) intake and blood lipid parameters. Dietary information was collected by two non-consecutive 24-h recalls in 1804 European adolescents. Compliance with the Food-Based Dietary Guidelines was expressed by calculating the Diet Quality Index ...
Yi Chucai - - 2013
In this paper, we propose a novel algorithm to detect text information from natural scene images. Scene text classification and detection are still open research topics. Our proposed algorithm is able to model both character appearance and structure to generate representative and discriminative text descriptors. The contributions of this paper ...
Tello J Ignacio - - 2013
We consider a simple mathematical model of tumor growth based on cancer stem cells. The model consists of four hyperbolic equations of first order to describe the evolution of different subpopulations of cells: cancer stem cells, progenitor cells, differentiated cells and dead cells. A fifth equation is introduced to model ...
Abhishek A - - 2013
Osteoarthritis (OA), the commonest arthropathy, targets the knees, hips, finger interphalangeal joints, thumb bases, first metatarsophalangeal joints, and spinal facet joints, and displays marked heterogeneity of clinical presentation. Signs of OA include coarse crepitus, bony enlargement, reduced range of movement, and joint-line tenderness. Muscle wasting and joint deformity occur with ...
Rodrigues Diego Samuel - - 2013
Dosage and frequency of treatment schedules are important for successful chemotherapy. However, in this work we argue that cell-kill response and tumoral growth should not be seen as separate and therefore are essential in a mathematical cancer model. This paper presents a mathematical model for sequencing of cancer chemotherapy and ...
Galhardo Alessandra Pucci Mantelli - - 2013
The aim of this study was to evaluate the performance of research diagnostic criteria for temporomandibular disorders (RDC/TMD) as a diagnostic test for temporomandibular joint problems using magnetic resonance imaging (MRI) as the gold standard. Sixty-seven women were assessed with RDC/TMD (2 examiners) and underwent MRI examination (3.0 T). Images ...
Löwenberg Mark - - 2013
In recent years, many new agents have been evaluated for the treatment of inflammatory bowel disease. In this paper, we critically review recently published literature about these novel therapies, which have been the result of extensive research identifying molecular targets. Of the various biologicals and small molecules that have recently ...
Properzi Enrico - - 2013
In this article we show how dichotomic classes, binary variables naturally derived from a new mathematical model of the genetic code, can be used in order to characterize different parts of the genome. In particular, we analyze and compare different parts of whole chromosome 1 of Arabidopsis thaliana: genes, exons, ...
Goldstein Lou Ann - - 2013
ABSTRACT Family involvement is essential to the developmental outcome of infants born into Neonatal Intensive Care Unit (NICU). In this article, evidence has been presented on the parent's perspective of having an infant in the NICU and the context of family. Key points to an educational assessment are also reviewed. ...
Ramakrishna Harish - - 2013
Cardiothoracic and vascular critical care has emerged as a subspecialty due to procedural breakthroughs, an aging population, and a multidisciplinary collaboration. This subspecialty now has a dedicated professional society, recently published guidelines, and plans for standardized certification. This paradigm shift represents a major collaboration opportunity for our specialty. The rise ...
Behnia Mehdi - - 2013
The purpose of the study was to measure the improvement in vision and contrast sensitivity in patients with central serous chorioretinopathy after macular subthreshold laser therapy. Cases included in this clinical trial were patients diagnosed with acute central serous chorioretinopathy less than 1 month in duration. Each patient was randomized ...
Neff Guy W - - 2013
The purpose of this study was to assess the incidence of Clostridium difficile infection in patients who received rifaximin for the treatment of hepatic encephalopathy (HE). Medical charts of patients who received rifaximin for the treatment of HE were reviewed. The number of patients who developed diarrhea during treatment with ...
Siegwart John T JT Jr Department of Vision Sciences, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama 35294-4390, USA. - - 2013
To determine if early restraint of axial elongation in response to plus lenses increases the subsequent response to interrupted hyperopia in tree shrews. The normal interrupted hyperopia group (n = 5) had normal visual exposure until 24 days of visual experience (VE). Then, from 24 to 45 days of VE, ...
Suk Jung Im JI Department of Neurology, School of Medicine, Catholic University of Daegu, 3056-6, Daemyeong-4-dong, Nam-gu, Daegu, South Korea. - - 2013
Over the last decade, neuromuscular ultrasonography has emerged as a useful tool for the diagnosis of peripheral nerve disorders. This article reviews sonographic findings of normal nerves, including key quantitative ultrasound measurements that are helpful in the evaluation of focal and possibly generalized peripheral neuropathies. It also discusses several recent ...
Armstead William M WM Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA. - - 2013
Traumatic brain injury contributes to morbidity in children and boys are disproportionately represented. Autoregulation is impaired more in male compared with female piglets after traumatic brain injury through sex-dependent up-regulation of the spasmogen endothelin-1 and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK), a family of three kinases: ERK, p38, ...
Schambach Axel A Institute of Experimental Hematology, Hannover Medical School, D-30625 Hannover, - - 2013
Over the past decades, lentiviral vectors have evolved as a benchmark tool for stable gene transfer into cells with a high replicative potential. Their relatively flexible genome and ability to transduce many forms of nondividing cells, combined with the potential for cell-specific pseudotyping, provides a rich resource for numerous applications ...
Singh Jasvinder A JA Medicine Service and Center for Surgical Medical Acute care Research and Transitions (C-SMART), Birmingham VA Medical Center, Birmingham, AL 35294, USA. - - 2013
Gout affects 8.3 million Americans according to NHANES 2007-2008, approximately 3.9 % of the US population. Gout has substantial effect on physical function, productivity, health-related quality of life (HRQOL), and health care costs. Uncontrolled gout is also associated with significant use of emergency care services. Women are less likely to have ...
Spence John Paul JP Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, IN 46202, - - 2013
The alcohol-preferring (P) and -nonpreferring (NP) rat lines were developed using bidirectional selective breeding for alcohol consumption (g/kg/day) and alcohol preference (water:ethanol ratio). During a preliminary study, we detected a difference in body weight between inbred P (iP) and inbred NP (iNP) rats that appeared to be associated with the ...
Fernandes Peter M PM Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK. - - 2013
Diagnosing stroke is not always straightforward. Stroke mimics such as Todd's paresis or hemiplegic migraine account for between a fifth and a quarter of suspected strokes (depending on the setting in which they are assessed). Stroke chameleons can arise when the tempo of symptom onset is not apoplectic or if ...
MacDonald D D Division of Oral and Maxillofacial Radiology, Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, - - 2013
The solitary keratocystic odontogenic tumor (KCOT) is a neoplasm, which recurs in 28% of cases. The purpose of this study is to determine whether clinicoradiographic features can predict recurrence. From 2000 to 2009, 106 solitary KCOTs were retrieved from the Oral Biology Service of British Columbia. Among 58 KCOTs including ...
VanderBeek Brian L BL Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA. - - 2013
To determine if statins are associated with the development or progression of age-related macular degeneration (AMD). A large, national insurance claims database was reviewed to identify individuals aged 60 years or older who were enrolled for ≥2 years and had ≥1 visits to an eye provider. Prescription claims for statins ...
Cheng Sam X SX Section of Gastroenterology, Department of Pediatrics, Yale University, New Haven, CT, - - 2013
Celiac disease and inflammatory bowel disease including ulcerative colitis (UC) and Crohn's disease are both immune-mediated enteropathies. It is rare for both celiac disease and inflammatory bowel disease to occur together in an individual patient. This association has been reported in adults, however, very rarely in children. Here, we report ...
Di Cello Francescopaolo F Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, - - 2013
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive leukemia with high relapse rates compared to B-lineage ALL. We previously showed that HMGA1a transgenic mice develop aggressive T-ALL, indicating that HMGA1 causes leukemic transformation in vivo. HMGA1 is also highly expressed in embryonic stem cells, hematopoietic stem cells and diverse, refractory ...
Ruben Eliza A EA Department of Biochemistry, Stanford University, Stanford, CA 94305, - - 2013
We compared the binding affinities of ground state analogues for bacterial ketosteroid isomerase (KSI) with a wild-type anionic Asp general base and with uncharged Asn and Ala in the general base position to provide a measure of potential ground state destabilization that could arise from the close juxtaposition of the ...
Chaudhuri Arunima A Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Uppal Road, Hyderabad 500 007, - - 2013
Water plays a fundamental role in the folding, structure, dynamics, and function of proteins and peptides. The extracellular N-terminal domain of chemokine receptors is crucial in mediating binding affinity, receptor selectivity, and regulating function. The flexible N-terminal domain becomes ordered in membranes and membrane-mimetic assemblies, thereby indicating that the membrane ...
Ehrenman Karen K Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, - - 2013
Cryptosporidium spp. are responsible for devastating diarrhoea in immunodeficient individuals. In the intestinal tract, the developmental stages of the parasite are confined to the apical surfaces of epithelial cells. Upon invasion, Cryptosporidium incorporates the microvillous membrane of the enterocyte to form the parasitophorous vacuole (PV) and sequesters itself from the ...
Kumar Nigam N Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, - - 2013
Reactive oxygen species (ROS) play crucial roles in physiology and pathology. In this report, we use NMR spectroscopy and mass spectrometry (MS) to demonstrate that proteins (galectin-1, ubiquitin, RNase, cytochrome c, myoglobin, and lysozyme) under reducing conditions with dithiothreitol (DTT) become alkylated at lysine-N(ζ) groups and O-phosphorylated at serine and ...
Yu Yixuan Y Department of Chemical Engineering, Texas Materials Institute, and Center for Nano- and Molecular Science and Technology, The University of Texas at Austin, Austin, Texas 78712-1062, United - - 2013
H-terminated Si nanocrystals undergo room temperature hydrosilylation with bifunctional alkenes with distal polar moieties-ethyl ester, methyl ester, or carboxylic acids-without the aid of light or added catalyst. The passivated Si nanocrystals exhibit bright photoluminescence (PL) and disperse in polar solvents, including water. We propose a reaction mechanism in which ester ...
Tang Jingling J Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599-7360, United - - 2013
Multidrug resistance (MDR) is a major barrier to the chemotherapy treatment of many cancers. However, some nonionic surfactants, for example, Brij, have been shown to restore the sensitivity of MDR cells to such drugs. The aim of this study was to explore the reversal effect of Brij on MDR tumor ...
McCormack Michael P MP Department of Chemistry, The University of Vermont, 82 University Place, Burlington, Vermont 05405, - - 2013
A concise entry to functionalized indolizidine scaffolds through a domino 2-aza-Cope-[3 + 2] dipolar cycloaddition and Pauson-Khand [2 + 2 + 1] cyclization has been accomplished. The process was conducted under mild conditions to afford diverse indolizidine systems as single diastereomers in good overall yields.
Zhu Rui R Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, - - 2013
O(6)-Alkylguanine-DNA alkyltransferase (AGT) is a DNA repair protein which removes alkyl groups from the O-6 position of guanine, thereby providing strong resistance to anticancer agents which alkylate this position. The clinical usefulness of these anticancer agents would be substantially augmented if AGT could be selectively inhibited in tumor tissue, without ...
1 2 3 4 5 6 7 8 9 10 >