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Das Ronnie R Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA. - - 2013
Interfacial water lying next to hydrophilic surfaces has been shown to be spectroscopically, mechanically, and electrically distinct from bulk water. Interfacial water has also been shown to exclude negatively and positively charged microspheres and has thus become known as the "exclusion zone". Measurements have demonstrated that exclusion zones exhibit a ...
Oliver Carrie H CH Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, United - - 2013
The functions of members of the large family of transcriptional repressors, the KRAB domain zinc finger proteins, are not well described. We have identified a new member of this family, Zfp157, as a downstream target of the transcription factor Stat6 in mammary gland. Using a gene-trap approach, we have generated ...
Zhang Yinan - - 2013
A novel method to construct the 1-aryl-3-piperidone scaffold is described here. Starting from 3,5-dichloroaniline, a seven-step synthesis, without the use of protecting groups, generates the desired 3-piperidone ring in an overall yield of 30% through a key Morita-Baylis-Hillman reaction and ring-closing metathesis, providing easy access to diverse and useful heterocycles.
Han Junyan - - 2013
Novel fluorescent dyes with ultra pseudo-Stokes Shift were prepared based on intramolecular energy transfer between a fluorescent donor and a Cyanine-7 acceptor. The prepared dyes could be excited at ~ 320 nm and emit fluorescence at ~ 780 nm. The energy transfer efficiencies of the system are found to be ...
Gucinski Ashley C AC Department of Chemistry and Biochemistry, The University of Arizona, 1306 East University Boulevard, P.O. Box 210041, Tucson, Arizona 85721-0041, USA. - - 2013
To probe the structural implications of the proline residue on its characteristic peptide fragmentation patterns, in particular its unusual cleavage at its C-terminus in formation of a b(2) ion in XxxProZzz sequences, the structures of a series of proline-containing b(2)(+) ions were studied by using action infrared multiphoton dissociation (IRMPD) ...
Feldman Ken S - - 2013
The pentacyclic Melodinus alkaloid (±)-meloscine was synthesized in 19 chemical steps from 2-bromobenzaldehyde through a route featuring an allenyl azide cyclization cascade to deliver the core azabicyclo[3.3.0]octane substructure. Peripheral functionalization of this core included a Tollens-type aldol condensation to set the quaternary center at C(20) and a diastereoselective ring closing ...
Patel Rhusheet R Multiple Sclerosis Program, Department of Neurology, University of California, Los Angeles, CA 90095-1769, - - 2013
Sex differences in the structure and organization of the corpus callosum (CC) can be attributed to genetic, hormonal or environmental effects, or a combination of these factors. To address the role of gonadal hormones on axon myelination, functional axon conduction and immunohistochemistry analysis of the CC in intact, gonadectomized and ...
D'Antonio Gianluca - - 2013
The basement membrane (BM) and extracellular matrix (ECM) play critical roles in developmental and cancer biology, and are of great interest in biomathematics. We introduce a model of mechanical cell-BM-ECM interactions that extends current (visco)elastic models (e.g. [8,16]), and connects to recent agent-based cell models (e.g. [2,3,20,26]). We model the ...
Lugonja Nikoleta - - 2013
Early-onset and exclusive breast-feeding provides a significant health benefit to infants compared with infant formulas. The aim of this study was to compare mature breast milk with standard infant formulas by examining their effects on non-vascular smooth muscle contraction and their antioxidative properties. The pharmacologic effects of breast milk and ...
Ezekowitz Justin A - - 2013
Acute heart failure is a public health issue with morbidity and mortality exceeding that of myocardial infarction. Novel compounds for the treatment of acute heart failure are clearly needed and fall into the general categories of inotropic, vasodilatory and other compounds in phase I to III of development. Furthest along ...
Dubois Christopher - - 2013
Experimental evidence suggests that a tumor's environment may be critical to designing successful therapeutic protocols: Modeling interactions between a tumor and its environment could improve our understanding of tumor growth and inform approaches to treatment. This paper describes an efficient, flexible, hybrid cellular automaton-based implementation of numerical solutions to multiple ...
Campbell Suzann K - - 2013
ABSTRACT The purpose of this special issue of Physical & Occupational Therapy in Pediatrics is to present an evidence-based system to guide the physical therapy management of patients in the Neonatal Intensive Care Unit (NICU). Two systematic guides to patient management will be presented. The first is a care path ...
Taneja Ravi - - 2013
The purpose of this study was to evaluate the mechanisms of cardiopulmonary bypass (CPB)-induced dysregulation between thrombin and its regulatory anticoagulant activated protein C (APC). A prospective observational cohort study. A tertiary care university hospital and associated research laboratory. Twenty patients undergoing elective coronary artery bypass surgery with (n = ...
Eley Karen A - - 2013
The objectives of this study were to determine the benefit of pretreatment magnetic resonance imaging (MRI)-based tumor volume (Tv) measurements in patients presenting with squamous cell carcinomas (SCCs) involving the oral cavity subsites most frequently associated with mandibular bone invasion. A 10-year retrospective study of all patients undergoing surgical resection ...
Edinburgh Laurel D - - 2013
How do Hmong immigrant adolescent girls decide to run away, return home, leave again, or stay home? Video diaries by 11 sexually exploited runaway Hmong girls, ages 13-16, revealed four themes: "fighting restrictions," or resisting family and cultural expectations and desires to be like other American teens; "not running away, ...
Bodnar Marek - - 2013
In the paper we consider the model of tumour angiogenesis process proposed by Bodnar and Fory (2009). The model combines ideas of Hahnfeldt et al. (1999) and Agur et al. (2004) describing the dynamics of tumour, angiogenic proteins and effective vessels density. Presented analysis is focused on the dependance of ...
Huda Saif - - 2013
A middle-aged man of South Asian decent presented with a 4-month history of bilateral sensory disturbance affecting the median nerve distribution and dorsum of both feet. Neurological examination was otherwise normal. A patchy absence of sensory responses was noted on nerve conduction studies and electromyogram (NCS/EMG). Over the next 3 months ...
Chen Susie A - - 2013
Locoregional control is associated with breast cancer-specific and overall survival in select women with breast cancer. Although several patient, tumor, and treatment characteristics have been shown to contribute to locoregional recurrence (LRR), studies evaluating factors related to radiotherapy (XRT) technique have been limited. We investigated the relationship between LRR location ...
Scianna Marco - - 2013
Cell migration on and through extracellular matrix is fundamental in a wide variety of physiological and pathological phenomena, and is exploited in scaffold-based tissue engineering. Migration is regulated by a number of extracellular matrix- or cell-derived biophysical parameters, such as matrix fiber orientation, pore size, and elasticity, or cell deformation, ...
Wilson David R - - 2013
Mechanics play a role in the initiation and progression of osteoarthritis. However, our understanding of which mechanical parameters are most important, and what their impact is on the disease, is limited by the challenge of measuring the most important mechanical quantities in living subjects. Consequently, comprehensive statements cannot be made ...
Pun Stephanie Y - - 2013
The most favorable mechanical environment for the hip is one that is free of both instability and impingement, creating a concentric articulation with optimum femoral head coverage by the acetabulum. Anatomic variations such as acetabular dysplasia with associated instability, and femoroacetabular impingement with abnormal constraint, will lead to abnormal joint ...
Taub Pam R - - 2013
Epidemiological data demonstrates that improved regulation of blood glucose correlates with better cardiovascular (CV) outcomes. Conversely, some interventional studies have demonstrated that tight glycemic control has no benefit or can even result in worse CV outcomes. These conclusions parallel the paradox that glycemic control has proven beneficial for microvascular outcomes, ...
De Ambrosi Cristina - - 2013
We started offering an introduction to very basic aspects of molecular biology, for the reader coming from computer sciences, information technology, mathematics. Similarly we offered a minimum of information about pathways and networks in graph theory, for a reader coming from the bio-medical sector. At the crossover about the two ...
Barichella Michela - - 2013
Dietary treatment is important for the management of Parkinson's disease (PD). Our objective was to describe the dietary habits and assess the nutritional status of Ghanaian patients with PD. This study is part of a larger project, for which Ghana has been selected as a pilot country. Fifty-five Ghanaian patients ...
Ahamed Maqusood - - 2013
In medicine, the use of silica nanoparticles (SiO(2) NPs) offers new perspectives in biosensor, drug delivery and cancer therapy. However, questions about potential toxic and deleterious effects of SiO(2) NPs have also been raised. The aim of this study was to investigate the induction of cytotoxicity, oxidative stress and apoptosis ...
Yu Xiaodan - - 2013
Knowledge about the hippocampal morphologic mechanisms of learning and memory for maternal mild zinc deficiency during pregnancy/lactation followed by zinc supplementation of pups after weaning is limited. This study examined the effects of zinc deficiency and zinc supplementation on cognition and hippocampal neurons. One-day pregnant rats were randomly divided into ...
Bogovic John A - - 2013
Deformable models are widely used for image segmentation, most commonly to find single objects within an image. Although several methods have been proposed to segment multiple objects using deformable models, substantial limitations in their utility remain. This paper presents a multiple object segmentation method using a novel and efficient object ...
Zhang Xiaolan - - 2013
Abstract Hepcidin is an iron regulatory protein mainly synthesized by the liver. Hepatocyte production of hepcidin is responsible for serum hepcidin, is responsive to body iron stores, and is critical for maintaining iron homeostasis. Monocytes and macrophages also express hepcidin, and in contrast to the liver, hepcidin expression is primarily ...
Billy Frederique - - 2013
Cell proliferation is controlled by many complex regulatory networks. Our purpose is to analyse, through mathematical modeling, the effects of growth factors on the dynamics of the division cycle in cell populations. Our work is based on an age-structured PDE model of the cell division cycle within a population of ...
Matthews Gloria L - - 2013
Osteoarthritis (OA) is a significant and growing concern to a large segment of the population. Effective treatments for slowing or stopping the progression of the disease are not available despite a great deal of investment-backed effort on the part of academia, government, and the pharmaceutical industry. Target selection has been ...
Pawlotsky Jean-Michel - - 2013
Hepatitis C virus (HCV) RNA level monitoring is currently used to guide the duration of interferon-containing treatment regimens. Nowadays, HCV RNA level quantification is based on real-time polymerase chain reaction assays that are both sensitive and accurate. Assessing the virological response to therapy is used to shorten treatment duration in ...
Bunn Belinda K - - 2013
Kaposi sarcoma is the most common HIV-associated neoplasm, frequently presenting with oral mucosal involvement. This retrospective study aimed to assess and highlight the histomorphological spectrum of oral Kaposi sarcoma. A total of 135 cases diagnosed between 1990 and 2011 were retrieved from the archives of the Oral and Dental Hospital ...
Vurucu S - - 2013
The aim of this study was to investigate the relationship between oxidative stress and chronic daily headache (CDH) in children. Although there are reports that oxidative injury may play a role in the pathophysiology of some neurologic disorders, such as migraine and epilepsy, by disrupting or destroying cell membranes through ...
Bueno Milena Baptista - - 2013
To estimate the nutritional risk in children 2 to 6 y old. The sample consisted of 3058 children enrolled in public and private schools in nine Brazilian cities. The assessment of nutrient intake was based on 1-d data combining direct individual weighing of foods and a food diary. A second ...
Wiles Charles Mark - - 2013
Neurological examination (NE) is a key part of practice for many doctors. UK students learn NE from a variety of specialty tutors and often find it difficult. This article suggests one way of introducing NE interactively with students in their first clinical year supplementary to clerking patients. The content presupposes ...
Sclair Seth N - - 2013
There have been recent key advances in the understanding of hepatitis E virus infection. Since the early 1980s, when the virus was first discovered, hepatitis E has been described as a disease that is endemic only in the African and Asian subcontinents, a disease that is transmitted via the fecal-oral ...
Fimmel Elena - - 2013
In this work an optimization problem for a leukemia treatment model based on the Gompertzian law of cell growth is considered. The quantities of the leukemic and of the healthy cells at the end of the therapy are chosen as the criterion of the treatment quality. In the case where ...
Byrne Eilish - - 2013
ABSTRACT This article presents the elements of the Observation and Assessment section of the Infant Care Path for Physical Therapy in the Neonatal Intensive Care Unit (NICU). The types of physical therapy assessments presented in this path are evidence-based and the suggested timing of these assessments is primarily based on ...
Macintyre Linda M - - 2013
Malawi women are in the ironic juxtaposition of being socially disempowered while, at the same time, thought to hold the key to shaping an effective community response to the HIV crisis. Based on this juxtaposition, a descriptive, qualitative study was conducted in Malawi and the United States where 26 participants ...
Barbosa Vanessa Maziero - - 2013
ABSTRACT Medical and technological advances in neonatology have prompted the initiation and expansion of developmentally supportive services for newborns and have incorporated rehabilitation professionals into the neonatal intensive care unit (NICU) multidisciplinary team. Availability of therapists specialized in the care of neonates, the roles of rehabilitation professionals, and models of ...
McEniry M - - 2013
Population aging and subsequent projected large increases in chronic conditions will be important health concerns in low- and middle-income countries. Although evidence is accumulating, little is known regarding the impact of poor early-life conditions on older adult (50 years and older) health in these settings. A systematic review of 1141 ...
Wang Lin - - 2013
Puerarin (PU), a natural flavonoid, has been reported to possess anti-oxidative and anti-inflammatory activities. In the present study, female Sprague-Dawley rats received lead (Pb) nitrate (300 mg/L, via drinking water) and/or PU (400 mg/kg/day, orally) to investigate the protective effects of PU on Pb-induced renal damage. Renal toxicity was evaluated by detecting ...
Azadbakht Leila - - 2013
To assess the association between consuming or skipping breakfast and dietary quality indices such as the Healthy Eating Index (HEI), the Dietary Diversity Score (DDS), diversity scores of different food groups, and anthropometric measurements in young Isfahanian women. Women 18 to 28 y old were selected randomly from among university ...
Popoola Bayode Isaiah - - 2013
The researcher investigated occupational hazards of sex work and determined coping strategies adopted by female sex workers in Nigeria. Participants were 112 female sex workers selected from three urban towns in southwestern Nigeria. An instrument titled "Questionnaire on Sex Work" adapted from Akinnawo ( 1995 ) was administered to collect ...
Asrani Sumeet K - - 2013
Significant strides have been made in the last few years in advancing our knowledge of the natural history of cirrhosis. These include (1) a better understanding of prognosis in compensated and decompensated cirrhosis, (2) improved estimates of the natural course of variceal bleeding in patients receiving standard of care therapy, ...
Chanpong Brian - - 2013
The purpose of this study was to develop a methodological technique for the ultrasonographic visualization of the inferior alveolar nerve (IAN) using a novel hockey stick-shaped 8- to 15-MHz transducer in volunteers, followed by simulated IAN scanning and injection in cadavers. In 20 volunteers, bilateral scans of the IAN nerve ...
Huang Yang-Mu - - 2013
This randomized controlled trial examined serum and macular (in vivo measured macular pigment optical density [MPOD]) responses to supplemental lutein and zeaxanthin in Chinese subjects with early age-related macular degeneration. One hundred and eight patients with early age-related macular degeneration older than 50 y were randomized to low lutein (LL; 10 ...
Morales-Rodrigo Cristian - - 2013
This paper is devoted to a nonlinear system of partial differential equations modeling the effect of an anti-angiogenic therapy based on an agent that binds to the tumor angiogenic factors. The main feature of the model under consideration is a nonlinear flux production of tumor angiogenic factors at the boundary ...
Garber June - - 2013
ABSTRACT This article presents the elements of the Oral Motor Intervention section of the Infant Care Path for Physical Therapy in the Neonatal Intensive Care Unit (NICU). The types of physical therapy interventions presented in this path are evidence based as well as infant driven and family focused. In the ...
Gomes Carolina Cavaliéri - - 2013
The objective of this study was to assess loss of heterozygosity (LOH) in tumor suppressor gene loci in oral granular cell tumors (GCTs). We assessed LOH in 8 samples of oral GCT using polymorphic microsatellite markers at chromosome regions 3p, 9p, 11q, and 17p, flanking areas close to tumor suppressor ...
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