Search Results
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Cuisset Thomas - - 2013
Variability of response to clopidogrel and prasugrel is a multifactorial process, with clinical consequences, and drug-drug interactions have been proposed as potential factors. Biological modulation of clopidogrel response has been demonstrated for atorvastatin and omeprazole. However, investigations assessing clinical relevance of these findings have been heterogeneous, and real clinical impact ...
Frozza Rudimar L - - 2013
Alzheimer's disease (AD), a neurodegenerative disorder exhibiting a gradual decline in cognitive function, is characterized by the presence of neuritic plaques composed of neurofibrillary tangles and amyloid-β (Aβ) peptide. Available drugs for AD therapy have small effect sizes and do not alter disease progression. Several studies have been shown that ...
Washburn Shannon E - - 2013
Fetal alcohol syndrome (FAS) is a significant problem in human reproductive medicine. Maternal alcohol administration alters maternal amino acid homeostasis and results in acidemia in both mother and fetus, causing fetal growth restriction. We hypothesized that administration of glutamine, which increases renal ammoniagenesis to regulate acid-base balance, may provide an ...
Endo Masayuki - - 2013
PURPOSE: Celiac trunk coil embolization before thoracic endovascular aneurysm repair (TEVAR) of a thoracoabdominal aortic aneurysm involving the celiac trunk can prevent type II endoleaks. One disadvantage of conventional coil embolization is the risk of coil displacement. We performed coil embolization under balloon occlusion of the celiac trunk to address ...
Hernández María Isabel - - 2013
Abstract Aim: To compare pubertal development in age-matched healthy girls born with low birth weight (LBW) or appropriate birth weight for gestational age (AGA). Subjects and methods: Girls with breast in Tanner stage II and normal body mass index were followed for 3 years with a complete physical exam, bone ...
Matsubara Takeshi - - 2013
Allergenic potential of food proteins is associated with stability to gastric and pancreatic digestive enzymes. However, much attention has not been focused on intracellular digestion of protein antigens during the passage through intestinal epithelia. We report here the degradation and survival of a bis-phosphorylated protein, ovalbumin, in the course of ...
Leong Darryl P - - 2013
OBJECTIVES: Right ventricular (RV) function is an important prognostic marker in heart failure. However, its impact on all-cause mortality following cardiac resynchronisation therapy (CRT) independent of confounding factors has not been evaluated. Furthermore, evidence concerning the effect of CRT on RV function is limited. The study's aims were to: (1) ...
Ueda Kazuhiro - - 2013
OBJECTIVES: Absorbable mesh and fibrin glue applied to prevent alveolar air leakage contribute to reducing the length of chest tube drainage, length of hospitalization and the rate of pulmonary complications. This study investigated the feasibility of omitting chest tube drainage in selected patients undergoing thoracoscopic major lung resection. METHODS: Intraoperative ...
Peguero Anthony A - - 2013
There is a growing body of research that suggests parallels between assimilation and increased adolescent violence, which is often referred to as the "immigrant paradox" in the United States. Few studies explore how theories, such as routine activity and lifestyle, could explain the relationship between assimilation and increased violence. This ...
Ramachandran Nivetha - - 2013
X-linked Myopathy with Excessive Autophagy (XMEA) is a childhood onset disease characterized by progressive vacuolation and atrophy of skeletal muscle. We show that XMEA is caused by hypomorphic alleles of the VMA21 gene, that VMA21 is the diverged human ortholog of the yeast Vma21p protein, and that like Vma21p, VMA21 ...
Tu Pei-Chi - - 2013
Recent resting fMRI studies have suggested that the functional connectivity of the brain's large-scale networks is associated with the cognitive decline of aging and is modulated by genetic factors. Our previous study found a significant association between interleukin-1 (IL-1 beta) C-511T polymorphism and working memory performance among elderly people. This ...
Willemink Martin J - - 2013
OBJECTIVES: To explain the technical principles of and differences between commercially available iterative reconstruction (IR) algorithms for computed tomography (CT) in non-mathematical terms for radiologists and clinicians. METHODS: Technical details of the different proprietary IR techniques were distilled from available scientific articles and manufacturers' white papers and were verified by ...
Ayari H - - 2013
ABSTRACT Purpose: Vascular calcification was considered to be a passive, degenerative, and end-stage process of vascular disease. However, bone associated proteins such as bone morphogenetic proteins, osteopontin, osteonectin, osteocalcin, and matrix Gla protein (MGP) have been found in the calcified atherosclerotic lesions. We studied by microarray analysis whether intact tissue ...
Mao Limin - - 2013
HIV-related risk perceptions and risk practices among gay men have changed over time. We revisited perceived HIV risk and engagement in anal intercourse with casual partners among HIV-negative gay men who participated in one of the Sydney Gay Community Periodic Surveys (GCPS). Perceived HIV risk was assessed by a range ...
Coulibaly G - - 2013
In subjects infected with HIV, proteinuria could represent a marker of HIV associated nephropathy (HIVAN), the most important cause of chronic renal failure in them. To determine the prevalence of proteinuria in children with HIV infection and to improve the screening of renal disease for these children in our country, ...
Yang Jun - - 2013
Hirschsprung's disease (HSCR) is a complex developmental defect characterized by the absence of enteric ganglia in the gastrointestinal tract. Although the genetic defect of enteric nervous system (ENS) was identified to play a critical role in the progress of HSCR, the systemic genetic dissection of HSCR still needs to be ...
Sawano Yukari - - 2013
PURPOSE: The purpose of this study was to compare the dose-related effects of fentanyl on systemic hemodynamics, hormone release and cardiac output in response to endotracheal intubation in patients with and without hypertension. METHODS: Forty-five patients without hypertension and 45 patients with hypertension (total 90 patients) undergoing elective general surgical, ...
Zhao Yong-Jun - - 2013
The performance and temporal variation of hybrid vertical-subsurface flow constructed wetlands (VFCWs) in response to two-stage combinations of vertical upflow (VUF) and vertical downflow (VDF) were analyzed in this research. The results of high carbon (C) treatment and high nitrogen (N) treatment were similar. The Lythrum salicaria treatment showed higher ...
Velasco Silvia - - 2013
Axon membrane glycoproteins are essential for neuronal differentiation, although the mechanisms underlying their polarized sorting and organization are poorly understood. We describe here that galectin-4 (Gal-4), a lectin highly expressed in gastrointestinal tissues and involved in epithelial glycoprotein transport, is expressed by hippocampal and cortical neurons where it is sorted ...
Cox Linda - - 2013
Allergen immunotherapy (AIT) is effective in reducing the clinical symptoms associated with allergic rhinitis, asthma and venom-induced anaphylaxis. Subcutaneous (SCIT) and sublingual immunotherapy (SLIT) with unmodified allergen extracts are the most widely prescribed AIT regimens. The efficacy of these 2 routes appears comparable, but the safety profile with SLIT is ...
Matsushima Hajime - - 2013
BACKGROUND: Prolonged hyperbilirubinemia (HB) following living donor liver transplantation (LDLT) can be a risk factor for early graft loss and mortality. However, some recipients who present with postoperative hyperbilirubinemia do recover and maintain a good liver function. AIM: The purpose of this study was to investigate the risk factors for ...
Kim Jon Jin - - 2013
OBJECTIVE: To analyse the demographics of children with moderate to severe chronic kidney disease (CKD) stages 3-5 over a 5-year period for the population of South East England. METHODS: Retrospective study of all children <18 years of age with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2) managed at Evelina ...
Shi Jiyan - - 2013
Abstract The release of nanoparticles (NPs) to the environment poses an increasing potential threat to biological systems. This study investigated the phytotoxicity and accumulation of copper oxide (CuO) NPs to Elsholtzia splendens (a Cu-tolerant plant) under hydroponic conditions. The 50 % effective concentration (EC(50)) of CuO NPs to E. splendens ...
Kawashiri Shin-Ya - - 2013
A 63-year-old male Japanese rheumatoid arthritis (RA) patient, in whom treatment with infliximab and methotrexate (MTX) had once led to drug-free remission, experienced a disease flare in July 2010. He was retreated with a combination of adalimumab and MTX, and clinical remission was achieved in 3 months. In contrast, power Doppler ...
Morino M - - 2013
The aim of oncologic surgery is radical cancer treatment with preservation of function and quality of life. Almost 30 years ago, transanal endoscopic microsurgery (TEM) revolutionised the technique and outcomes of transanal surgery, first becoming the standard of treatment for large rectal adenomas, then offering a possibly curative treatment for early ...
Zhao Hang - - 2013
Behçet's disease (BD) is a multi-system inflammatory disorder. We report the case of a BD patient with severe aortic root vasculitis. Two-dimensional transthoracic echocardiography (2DE) images suggested left Valsalva sinus aneurysm ruptured into the left ventricular outflow tract. However, preoperative transesophageal real-time 3-dimensional echocardiography (3DE) revealed that the aneurysm-like structure ...
Karthikeyan Marimuthu - - 2013
Abstract Background: The aim of the study was to evaluate the incidence of medication error and to categorize medication error in the general medicine department of a tertiary hospital. Thus, the study aims to promote safety in medication use and ensure quality in the healthcare service by effective utilization of ...
Kotsis Fruzsina - - 2013
Since the discovery that proteins mutated in different forms of polycystic kidney disease (PKD) are tightly associated with primary cilia, strong efforts have been made to define the role of this organelle in the pathogenesis of cyst formation. Cilia are filiform microtubular structures, anchored in the basal body and extending ...
Hansen Michael Riis - - 2013
The type I phosphoribosyltransferase OMP synthase (EC 2.4.2.10) is involved in de novo synthesis of pyrimidine nucleotides forming the UMP precursor orotidine 5'-monophosphate (OMP). The homodimeric enzyme has a Rossman α/β core topped by a base-enclosing "hood" domain and a flexible domain-swapped catalytic loop. High-resolution X-ray structures of the homologous ...
Hallen André - - 2013
A key intermediate in the glutamate dehydrogenase (GDH)-catalyzed reaction is an imine. Mechanistically, therefore, GDH exhibits similarities to the ketimine reductases. In the current review, we briefly discuss (a) the metabolic importance of the GDH reaction in liver and brain, (b) the mechanistic similarities between GDH and the ketimine reductases, ...
Hoet Perrine - - 2013
Abstract Background: Trace elements (TEs) are ubiquitous and their potential interest for human health has been constantly expanding. Biological monitoring is generally considered to be a useful tool to assess human exposure to chemical agents in risk assessment both at occupational and environmental levels. However, the knowledge of accurate reference ...
Olver Stuart - - 2013
Activation of naïve CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumor activity. Although this CD8(low) phenotype becomes stable after about a week and can ...
Lu Mei - - 2013
Transition metal thiolate complexes such as [PPN](+)[RuL(3)](-) (PPN = bis(triphenylphosphoranylidene) ammonium and L = diphenylphosphinobenzenethiolate) are known to undergo addition reactions with unsaturated hydrocarbons via the formation of new C-S bonds in solution upon oxidation. The reaction mechanism is proposed to involve metal-stabilized thiyl radical intermediates, a new type of distonic ions such as ...
Matsushige Toshinori - - 2013
INTRODUCTION: Our aim was to systematically investigate radiographic characteristics and outcome of diffusion-weighted imaging (DWI) changes in the elective coiling of unruptured cerebral aneurysm with analyzing the correlation of antiplatelet therapy (APT). METHODS: In a total of 34 consecutive patients with unruptured cerebral aneurysms initially treated by coiling without stent ...
Kojo Katja - - 2013
Increased incidence of skin cancers among airline cabin crew has been reported in several studies. We evaluated whether the difference in risk factor prevalence between Finnish airline cabin crew and the general population could explain the increased incidence of skin cancers among cabin crew, and the possible contribution of estimated ...
Akbaba Yusuf - - 2013
Abstract Six sulfonamides derived from indanes and tetralines were synthesized. The human carbonic anhydrase isozymes hCA I and hCA II inhibition effects of the synthesized sulfonamides were determined. From these compounds, while N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methane sulfonamide showed the most potent inhibitory effect against hCA I (K(i) = 46 ± 5.4 µM, r(2) = 0.978), N-(1,2,3,4-tetrahydronaphthalene-2-yl)methanesulfonamide was found to have ...
Wei Wei - - 2013
MicroRNAs (miRNAs) are recently discovered small RNA molecules that regulate developmental processes, such as proliferation, differentiation and apoptosis; however, the identity of miRNAs and their functions during liver development are largely unknown. Here, we investigated the miRNA and gene expression profiles for E8.5 endoderm, E14.5 Dlk1(+) liver cells (hepatoblasts), and ...
Pérez-Edgar Koraly - - 2013
Behavioral inhibition (BI), a temperament characterized by vigilance to novelty, sensitivity to approach-withdrawal cues, and social reticence in childhood, is associated with risk for anxiety in adolescence. Independent studies link reward hyper-responsivity to BI, adolescent anxiety, and dopamine gene variants. This exploratory study extends these observations by examining the impact ...
L Harrison - - 2013
BACKGROUND: There is a body of opinion in the clinical literature advocating the removal of intranasal contact points to treat facial pain. OBJECTIVES: To review the evidence that intranasal mucosal contact points cause facial pain or headache and their removal is therapeutic. TYPE OF REVIEW: Systematic review SEARCH STRATEGY: A ...
Elmadhoun Wadie M Y - - 2013
BACKGROUND: Infection with schistosomiasis and soil-transmitted helminthes (SSTH) constitutes a major health problem worldwide, yet the burden of disease is in the tropical countries. The disease is endemic in River Nile State, Sudan but the exact prevalence rate is unknown. METHODS: A survey of 2490 pupils in 103 basic schools ...
Goldstein Henry - - 2013
Abstract Parenting a child with chronic disease provides a unique set of challenges for both mothers and fathers throughout all phases of the illness. However, fathers of these children are under-represented in existing research. This review focuses on the fathers of children with chronic disease included in 44 original articles. ...
Swaminathan Anand - - 2013
Abstract Low-contrast retinal images have to be enhanced for good visual perception to aid in retinal vessel analysis. Classical sharpening enhancement techniques such as unsharp masking (USM) improve the contrast and bring out the information along with noise. This article uses a shift-invariant anisotropic Contourlet transform (CT) to decompose the ...
Gicquel Thomas - - 2013
A fast and sensitive liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed and validated for the simultaneous determination of acetaminophen (APAP) and its glucuronide and sulfate metabolites (APAP-GLU and APAP-SUL) in small plasma volumes. This method included a simple step of sample preparation and a chromatographic separation on an LC-MS-MS ...
Chou Hsun-Hua - - 2013
BACKGROUND: Cognitive deficits contribute strongly to functional disability in schizophrenia. The cost of identifying and testing candidate procognitive agents is substantial. Conceivably, candidate drugs might be first identified by positive effects on cognitive domains in sensitive subgroups of healthy subjects. Here, we examined whether the MATRICS Consensus Cognitive Battery (MCCB) ...
Volodarsky Michael - - 2013
Autosomal recessive osteogensis imperfecta (OI) was diagnosed in three unrelated Israeli Bedouin consanguineous families. Fractures were evident in all cases in infancy. Genome wide linkage analysis ruled out association with any of the known osteogenesis imperfecta (OI) genes, and identified a single homozygosity locus of ∼2 Mb on chromosome 9 ...
Tang Michelle C W - - 2013
Post-translational modifications to residues in core histones convey epigenetic information. Their function can be evaluated in amino acid substitution mutants, although to date this method has not been used in mice. To this end, we have evaluated gene targeting vectors designed for Cre recombinase-mediated conditional allelic replacement at the two ...
Qi Yujuan - - 2013
During spermiogenesis, the manchette is an important structure for sperm head and tail formation. However, the mechanisms responsible for this process are poorly understood. In a previous study, we established a comparative proteome profile for mouse testis during the first wave of spermatogenesis, and provided lists of proteins of potential ...
Kajino Yoshitomo - - 2013
BACKGROUND: Hip resurfacing arthroplasty has some advantages, including improved metal-on-metal articulation, a lower dislocation rate and preserved femoral bone. This procedure is a surgical option for younger and more active patients with osteoarthritis and osteonecrosis of the femoral head. Although there have been some reports about the efficacy of this ...
Jones Bruce Vivash - - 2013
The American Veterinary Medical Association is marking its 150th anniversary in 2013, celebrating '150 years of education, science and service'. As Bruce Vivash Jones explains, veterinary surgeons from the UK played a key role in establishing a system of veterinary education in North America.
Sieghart Wolfgang - - 2013
Background We aimed to establish an objective point score to guide the decision for retreatment with transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). Methods 222 patients diagnosed with HCC and treated with multiple TACE cycles between 1/1999 and 12/2009 at the Departments of Gastroenterology/Hepatology of the Medical Universities ...
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