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Results 701 - 750 of 4440
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Kawashiri Shin-Ya - - 2013
A 63-year-old male Japanese rheumatoid arthritis (RA) patient, in whom treatment with infliximab and methotrexate (MTX) had once led to drug-free remission, experienced a disease flare in July 2010. He was retreated with a combination of adalimumab and MTX, and clinical remission was achieved in 3 months. In contrast, power Doppler ...
Morino M - - 2013
The aim of oncologic surgery is radical cancer treatment with preservation of function and quality of life. Almost 30 years ago, transanal endoscopic microsurgery (TEM) revolutionised the technique and outcomes of transanal surgery, first becoming the standard of treatment for large rectal adenomas, then offering a possibly curative treatment for early ...
Yeh Yu Jie - - 2013
This study investigated plasma lipopolysaccharides (LPS) concentration and intestinal permeability after 60-min run at 70 % maximum oxygen uptake (VO(2max)) in hot [33 °C, 50 % relative humidity (rH)] and cool (22 °C, 62 % rH) conditions. Fifteen volunteers gave their informed consent to participate in this study. Their venous blood samples were taken before, ...
Lau Hui-Hsuan - - 2013
INTRODUCTION AND HYPOTHESIS: The transobturator suburethral sling is a common surgical treatment for stress urinary incontinence (SUI). In patients with incontinence after trocar-guided transvaginal mesh repair (Prolift™), data on outcome remain limited. In the present study, we hypothesized that transobturator tape in such cases is assumed to be as effective ...
Poirel Christopher L CL Department of Computer Science, Virginia Tech, Blacksburg, VA, - - 2013
Many techniques have been developed to compute the response network of a cell. A recent trend in this area is to compute response networks of small size, with the rationale that only part of a pathway is often changed by disease and that interpreting small subnetworks is easier than interpreting ...
Tang K - - 2013
The 3D thermoluminescent spectra and glow curves of LiF:Mg,Cu,Si with various Mg, Cu and Si concentrations were measured. The shapes of the glow curves in LiF:Mg,Cu,Si, LiF:Mg,Cu and LiF:Mg,Si are similar and the glow curves have peaks at approximately the same temperatures, but with significantly different intensities. Neither the temperature ...
Yokoi Tae - - 2013
To analyze both targeted and measured refractive errors in highly myopic eyes after phacoemulsification and intraocular lens implantation (PEA + IOL) and to examine the preoperative factors which influenced these refractive errors, we reviewed medical records of patients who had undergone PEA + IOL. Highly myopic eye was defined as one with axial length ...
Wallace Daniel J - - 2013
OBJECTIVE: To identify a suitable dosing regimen of the CD22-targeted monoclonal antibody epratuzumab in adults with moderately to severely active systemic lupus erythematosus (SLE). METHODS: A phase IIb, multicentre, randomised controlled study (NCT00624351) was conducted with 227 patients (37-39 per arm) receiving either: placebo, epratuzumab 200 mg cumulative dose (cd) ...
Schaballie Heidi - - 2013
Shwachman-Diamond syndrome (SDS) is an autosomal recessive disorder characterised by skeletal dysplasia, exocrine pancreatic insufficiency and bone marrow failure. Various other conditions, such as hepatopathy and failure to thrive have been associated with SDS. A retrospective study was conducted to describe mutations, clinical features, and the immunological profile of 11 ...
Misiorowski W - - 2013
ABSTRACT Purpose: Accelerated rate of bone turnover and increased resorption due to primary hyperparathyroidism (PHPT) result in osteopenia and an increase in the fracture risk. However, there are no data about the relative frequency of the PHPT in the subpopulation with the low bone mass. The aim of the study ...
Buysschaert Geraldine - - 2013
Short-chain dehydrogenases/reductases (SDR) encompass a large and functionally diverse family of enzymes with representative members in all kingdoms of life. Despite the wealth of reactions catalyzed by SDR, they operate through a well-conserved and efficient reaction mechanism centered in a conserved catalytic tetrad (Asn-Ser-Tyr-Lys), and the employment of an appropriate ...
Bu Jun - - 2013
Heroin is a highly addictive drug, and heroin abuse is considered to be a serious criminal act. The major metabolite of heroin, morphine, can usually be detected as evidence of heroin abuse. However, it is difficult to determine heroin use when morphine and codeine are both detected, because codeine use ...
Russell Robert D - - 2013
PURPOSE: Preoperative range of motion (ROM) has been regarded as one of the most important factors in predicting postoperative ROM following total knee arthroplasty (TKA). Mobile-bearing TKA designs have been suggested to possibly improve the knee kinematics compared to fixed-bearing designs. The purpose of this study was to examine the ...
Roy Amanda Leigh - - 2013
Although past research has demonstrated a "health disadvantage" for Puerto Rican adults, very little is known about correlates of health among this group. Given Puerto Ricans' unique experiences of migration and settlement, an ethnic enclave framework that integrates nativity, ethnic density, and neighborhood SES may offer insight into factors influencing ...
Navari Rudolph M - - 2013
PURPOSE: Olanzapine has been shown to be a safe and effective agent for the prevention of chemotherapy-induced nausea and vomiting (CINV). Olanzapine may also be an effective rescue medication for patients who develop breakthrough CINV despite having received guideline-directed CINV prophylaxis. METHODS: A double-blind, randomized phase III trial was performed ...
Pointon Amy A Molecular Toxicology, Global Safety Assessment UK, Innovative Medicines, AstraZeneca R&D, Macclesfield, SK10 4TG, UK. - - 2013
Morphological damage to cardiomyocytes or loss of viability (structural cardiotoxicity) is a common cause of attrition in preclinical and clinical drug development. Currently, no predictive in vitro approaches are available to detect this liability early in drug discovery, and knowledge of the mechanisms involved is limited. Human embryonic stem cell-derived ...
Bhide Alka A - - 2013
The role of muscle spasm is not a new concept in the genesis of pain. Botulinum neurotoxin type A (BoNTA) has been successfully employed in a variety of muscular and inflammatory conditions. The aim of our study was to review the published literature on the role of BoNTA injection of ...
Eid Tony T Orthopedic Surgery Department, Hotel-Dieu de France Hospital, Beirut, Lebanon. - - 2013
Congenital kyphoscoliosis (CKS) results from abnormal vertebral chondrification. Congenital fibrous bands occur in several locations with variable impact on vertebral development. We report a previously unreported case of a female infant with CKS presenting with an L2 hypoplastic vertebra and a costo-vertebral fibrous band extending to the skin in the ...
Hensey Conor C - - 2013
OBJECTIVE: To compare the efficacy of low-flow oxygen, low-flow air and sham treatment given via nasal cannulae in preventing desaturation (falls in oxygen saturation (SpO(2))) in preterm infants. STUDY DESIGN: Infants born at <33 weeks gestation receiving gas at flow rates <1 l/min via nasal cannulae were eligible for inclusion. ...
Pezic Angela - - 2013
Our aim was to examine the association between ethnicity, phenotype, sun behaviour and other characteristics, and constitutive and relative facultative skin pigmentation. 191 participants were recruited, with a mean age of 7.6 years (SD 3.4), during 2009-2011 from Maternal and Child Health Centres and schools in Melbourne, Australia. Parental questionnaire ...
Bao Yanyan - - 2013
MicroRNAs (miRNAs) are a novel class of powerful, endogenous regulators of gene expression. This study identified 16 differentially expressed miRNAs in ischemic myocardium of rats using TaqMan Low Density Array. In addition, bioinformatics analyses, such as Gene ontology and Pathway assays, were applied to determine the apoptosis pathway, only regulated ...
Richert Ranko - - 2013
Physical aging below the glass transition temperature, Tg, is generally understood to be governed by the same slow degrees of freedom that are responsible for structural relaxation in the equilibrium state above Tg. Provided a reliable model of aging is at hand, it should thus be possible to extract very ...
Fahey James R - - 2013
Currently, there is the potential to generate over 200,000 mutant mouse strains between existing mouse strains (over 24,000) and genetically modified mouse embryonic stem cells (over 209,000) that have been entered into the International Mouse Strain Resource Center (IMSR) from laboratories and repositories all over the world. The number of ...
Hoene Andreas - - 2013
Copper (Cu) could serve as antibacterial coating for Ti6Al4V implants. An additional cell-adhesive layer might compensate Cu cytotoxicity. This study aimed at in vitro and in vivo evaluation of low-temperature plasma treatment of Ti6Al4V plates with Ti/Cu magnetron sputtering (Ti6Al4V-Ti/Cu), plasma-polymerized ethylenediamine (Ti6Al4V-PPEDA), or both (Ti6Al4V-Ti/Cu-PPEDA). Ti6Al4V-Ti/Cu and Ti6Al4V-Ti/Cu-PPEDA had ...
Fahim Ayman Ekram - - 2013
OBJECTIVES: The aim of this study was to measure the level of job satisfaction and the work factors associated with it among practicing dentists in Suez Canal governorates hospitals. MATERIALS AND METHODS: Four hundred forty nine dentists were contacted, and 277 agreed to participate (response rate 61.7%). They were surveyed ...
Dietz H P - - 2013
INTRODUCTION AND HYPOTHESIS: Multichannel urodynamic testing is commonly used to diagnose urodynamic stress incontinence (USI). It has been claimed that USI may be diagnosed by imaging. In this study we determined the predictive value of ultrasound findings for USI. METHODS: This is an observational study utilising data obtained during urodynamic ...
Meek Rick L RL Providence Medical Research Center, Providence Sacred Heart Medical Center, Spokane, WA, USA. - - 2013
Overfeeding amino acids (AAs) increases cellular exposure to advanced glycation end-products (AGEs), a mechanism for protein intake to worsen diabetic kidney disease (DKD). This study assessed receptor for AGE (RAGE)-mediated apoptosis and inflammation in glomerular cells exposed to metabolic stressors characteristic of high-protein diets and/or diabetes in vitro with proof-of-concept ...
Caillol Fabrice - - 2013
BACKGROUND: Most modalities for tissue confirmation during endoscopic retrograde cholangiopancreatography (ERCP) suffer from low sensitivity and poor diagnostic accuracy. Probe-based confocal laser endomicroscopy (pCLE) was prospectively evaluated in a multicenter registry including 102 patients with indeterminate strictures and demonstrated excellent sensitivity (98 %). Yet, several false-positive cases were induced by benign ...
Sundqvist J - - 2013
Is it possible to replicate the previously identified genetic association of four single-nucleotide polymorphisms (SNPs), rs12700667, rs7798431, rs1250248 and rs7521902, with endometriosis in a Caucasian population? A borderline association was observed for rs1250248 and endometriosis (P = 0.049). However, we could not replicate the other previously identified endometriosis-associated SNPs (rs12700667, ...
Zhang Hai-Lan - - 2013
BACKGROUND: The optimal treatment of appendiceal phlegmon or abscess with an appendicolith is controversial. This study aimed to evaluate outcomes and prognosis of nonoperative management of appendiceal phlegmon or abscess with an appendicolith in children. METHODS: From 2007 to 2011, 105 children with appendiceal phlegmon or abscess who were treated ...
Tomek Petr - - 2013
Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan-catabolizing enzyme whose expression by a broad range of clinical tumors is associated with immunosuppression and poor patient outcome. Here we describe a new fluorescence assay for measuring IDO1 activity suitable for high-throughput screening of compound libraries for novel IDO1 inhibitors. This assay is ...
Tanaka Torahiko T Division of Biochemistry, Department of Biomedical Sciences and Nihon University School of Medicine, Tokyo 173-8610, - - 2013
Lipid droplets (LD) are dynamic storage organelles that are involved in lipid homeostasis. Hepatitis C virus (HCV) is closely associated with LDs. HCV Core and nonstructural (NS) proteins colocalize with LDs and presumably are involved in virion formation at that site. We demonstrated that HCV NS4B, an integral membrane protein ...
Kojo Katja - - 2013
Increased incidence of skin cancers among airline cabin crew has been reported in several studies. We evaluated whether the difference in risk factor prevalence between Finnish airline cabin crew and the general population could explain the increased incidence of skin cancers among cabin crew, and the possible contribution of estimated ...
Akbaba Yusuf - - 2013
Abstract Six sulfonamides derived from indanes and tetralines were synthesized. The human carbonic anhydrase isozymes hCA I and hCA II inhibition effects of the synthesized sulfonamides were determined. From these compounds, while N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methane sulfonamide showed the most potent inhibitory effect against hCA I (K(i) = 46 ± 5.4 µM, r(2) = 0.978), N-(1,2,3,4-tetrahydronaphthalene-2-yl)methanesulfonamide was found to have ...
Wei Wei - - 2013
MicroRNAs (miRNAs) are recently discovered small RNA molecules that regulate developmental processes, such as proliferation, differentiation and apoptosis; however, the identity of miRNAs and their functions during liver development are largely unknown. Here, we investigated the miRNA and gene expression profiles for E8.5 endoderm, E14.5 Dlk1(+) liver cells (hepatoblasts), and ...
Pérez-Edgar Koraly - - 2013
Behavioral inhibition (BI), a temperament characterized by vigilance to novelty, sensitivity to approach-withdrawal cues, and social reticence in childhood, is associated with risk for anxiety in adolescence. Independent studies link reward hyper-responsivity to BI, adolescent anxiety, and dopamine gene variants. This exploratory study extends these observations by examining the impact ...
Spankowsky S - - 2013
The oral administration of the amino acid, tyrosine, has been for years recommended in order to improve fertility, especially to improve copulation behaviour in female dogs. However, evidence is comparatively poor. The objective of our study was to determine whether oral administration of tyrosine has an effect on oestradiol-17β concentrations ...
Akre Christina - - 2013
Abstract This study aimed at exploring adolescents' perceptions of unwanted sexual experiences (USE) in order to set up definitions, categories, and boundaries on the continuum between consensual and non-consensual sex. Methods: We conducted a qualitative thematic analysis of four focus group discussions gathering a total of 29 male and female ...
Gao Yongshun Y Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, - - 2013
Few epidemiological studies have examined the relationship between dietary fat, which may affect immune function and risk of Hodgkin lymphoma (HL). The aim of this study was to test the hypothesis that high dietary intake of fat and specific subtypes of fat is associated with the risk of HL among ...
Courcoutsakis Nikos A - - 2013
The complex of myxomas, spotty skin pigmentation and endocrine overactivity, or Carney complex (CNC), is a familial multiple endocrine neoplasia and lentiginosis syndrome. CNC is inherited in an autosomal dominant manner and is genetically heterogeneous. Its features overlap those of McCune-Albright syndrome and other multiple endocrine neoplasia (MEN) syndromes. Spotty ...
Gilmore Thomas D - - 2013
This report summarizes information discussed at the second Nematostella vectensis research conference, which took place on August 27, 2012 in Boston, MA, USA. The startlet sea anemone Nematostella is emerging as one of leading model organisms among cnidarians, in part because of the extensive genome and transcriptome resources that are ...
Carr Brian I BI Department of Nutritional Carcinogenesis, IRCCS S. de Bellis, National Institute for Digestive Diseases, Via Turi 27, 70013, Castellana Grotte, BA, Italy. - - 2013
Thrombocytopenia has been reported to be both a risk factor for hepatocellular carcinoma (HCC) development as well as a prognostic factor. Many HCCs also occur in presence of normal platelets. To examine a cohort of HCC patients with associated thrombocytosis. Records were examined of a cohort of 634 biopsy-proven and ...
Patanwala Asad E - - 2013
OBJECTIVE: The primary objective of this study was to compare the analgesic response to morphine in non-obese, obese and morbidly obese patients for acute pain. METHODS: This was a retrospective cohort study conducted in a tertiary care emergency department in the USA. Consecutive adults who received intravenous morphine 4 mg ...
Dogan Vehbi - - 2013
The aim of our study was to evaluate myocardial functions with strain/strain rate echocardiography in asymptomatic patients having congenital aortic stenosis (CAS) with normal cardiac functions as determined by conventional echocardiographic techniques and comparing them with those of healthy controls. A total of 58 patients with various degrees of isolated ...
Présumey Jessy - - 2013
OBJECTIVES: Nicotinamide phosphoribosyltransferase (NAMPT)/pre-B-cell colony-enhancing factor/visfatin exerts multiple functions and has been implicated in the pathogenesis of rheumatoid arthritis. To gain insight into its role in arthritis and given that NAMPT is identified as a novel mediator of innate immunity, we addressed the function of monocyte-derived NAMPT in experimental arthritis ...
Al-Shamsi Mariam - - 2013
ABSTRACT: BACKGROUND: A novel in vitro system was employed to investigate liver tissue respiration (mitochondrial O2 consumption) in mice treated with concanavalin A (Con A). This study aimed to investigate hepatocyte bioenergetics in this well-studied hepatitis model. METHODS: C57Bl/6 and C57Bl/6 IFN-gamma-/- mice were injected intravenously with 12 mg ConA/kg. ...
El Kaffas Ahmed - - 2013
PURPOSE: Large doses of radiation (8-20 Gy) preferentially target tumor vasculature. This vascular response is suggested to regulate tumor response to radiotherapy. Here, we investigate the relative contributions of direct cell killing by radiation versus tumor cell death due to radiation effects on the vasculature. We also examine Sunitinib's mechanism of ...
Giordano Gennaro G Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA. - - 2013
Domoic acid (DomA) is a potent marine neurotoxin. By activating α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid/kainate receptors, DomA induces oxidative stress-mediated apoptotic cell death in neurons. The effect of prolonged (10 days) exposure to a low, nontoxic concentration (5nM) of DomA on acute (intermediate concentration) neurotoxicity of this toxin was investigated in cerebellar granule ...
Kaplan Kimberly A - - 2013
We report results of studies of global and targeted neuronal metabolomes by ambient pressure ion mobility mass spectrometry. The rat frontal cortex, striatum, and thalamus were sampled from control nontreated rats and those treated with acute cocaine or pargyline. Quantitative evaluations were made by standard additions or isotopic dilution. The ...
Moreno Ricardo - - 2013
ABSTRACT: BACKGROUND: Several studies seek biological markers that give diagnostic and degree of tumor development. The aim of this study was to validate the determination of plasma DNA using nanotechnology (NanovueTM-NV) in samples of 80 patients with prostate cancer. METHODS: Blood samples of 80 patients of the Urology Ambulatory of ...
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