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Results 551 - 600 of 4439
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Al-Shamsi Mariam - - 2013
ABSTRACT: BACKGROUND: A novel in vitro system was employed to investigate liver tissue respiration (mitochondrial O2 consumption) in mice treated with concanavalin A (Con A). This study aimed to investigate hepatocyte bioenergetics in this well-studied hepatitis model. METHODS: C57Bl/6 and C57Bl/6 IFN-gamma-/- mice were injected intravenously with 12 mg ConA/kg. ...
Dallos Tomás - - 2013
Objective. Haemochromatosis arthropathy is a secondary OA and the most frequent and earliest clinical presentation of hereditary haemochromatosis (HH). The aim of this study was to perform a direct clinical, functional and radiographic comparison with idiopathic hand OA (HOA) to unravel important differences between these clinical entities.Methods. In total, 299 ...
Cho Kwang Ho - - 2013
OBJECTS: During ontogeny, part of Rathke's pouch, a physiologically superior pouching of the stomodeal ectoderm, may remain, forming the usual anomaly known as Rathke's cleft cyst. More rarely, however, the entire pouch (i.e., the craniopharyngeal canal) remains, resulting in transsphenoidal meningoencephalocele. This study is aimed to provide a better understanding ...
Cao Ran - - 2013
Abstract Background: Tetramethylpyrazine (TMP) is used to treat cerebrovascular and cardiovascular diseases. However, it displays a short half-life that restricts clinical applications. 2-Hydroxymethyl-3,5,6-trimethylpyrazine (HTMP) is the principal active metabolite of TMP, with similar activity of TMP. Therefore, it makes sense to improve the biopharmaceutical characteristics via HTMP bypassing TMP. Purpose: ...
Zittermann Armin - - 2013
AimsA significant proportion of cardiac surgical patients develop critical post-operative complications. We aimed to investigate the association of pre-operative 25-hydroxyvitamin D (25(OH)D) levels with major cardiac and cerebrovascular events (MACCE) in cardiac surgical patients.Methods and resultsFrom January 2010 to August 2011, we consecutively measured circulating 25(OH)D in 4418 operated patients. ...
Mata-Rocha Minerva - - 2013
CatSper channels are essential for hyperactivity of sperm flagellum, progesterone-mediated chemotaxis and oocyte fertilisation. Catsper genes are exclusively expressed in the testis during spermatogenesis, but the function and regulation of the corresponding promoter regions are unknown. Here, we report the cloning and characterization of the promoter regions in the human ...
Creswell J David - - 2013
Brief periods of unconscious thought have been shown to improve decision-making compared to making an immediate decision. We reveal a neural mechanism for unconscious thought in decision making using BOLD contrast fMRI. Participants (N=33) encoded information on a set of consumer products (e.g., 48 attributes describing 4 different cars), and ...
Nakazawa Harumasa - - 2013
A 51-year-old Japanese male underwent on-pump coronary artery bypass grafting surgery. After weaning from cardiopulmonary bypass (348 min), sudden bradycardia and hypotension occurred, followed by ventricular fibrillation. Although defibrillation and infusion of catecholamine restored sinus rhythm, transesophageal echocardiography demonstrated severely reduced contraction of both ventricles, and perioperative vascular spasm was suspected. ...
Tsoi Ho - - 2013
Polyglutamine (polyQ) diseases, including several types of spinocerebellar ataxias and Huntington's disease (HD), are dominantly inherited neurodegenerative disorders caused by the expansion of the glutamine-coding CAG repeat in the open reading frame of the disease gene. Apart from being translated to produce toxic elongated polyQ domain-containing disease proteins, transcribed expanded ...
Kulkarni Sneha A - - 2013
PURPOSE: To investigate the effects of the particle size and surface coating on the cellular uptake of the polymeric nanoparticles for drug delivery across the physiological drug barrier with emphasis on the gastrointestinal (GI) barrier for oral chemotherapy and the blood-brain barrier (BBB) for imaging and therapy of brain cancer. ...
Gorman Ng Melanie - - 2013
Background:Although dustiness and viscosity are potential determinants of dermal exposure, their effect on exposure is poorly understood. The goal of this study was to investigate the effect of dustiness and viscosity on dermal exposure by each of three dermal exposure pathways (deposition, surface contact, and immersion). METHODS: The hands of ...
Hvaring Christina L - - 2013
This study aimed to assess infraocclusion, root resorption and restorations and their importance for the prognosis of retained primary mandibular molars lacking successors. The sample comprised 188 persisting primary mandibular second molars in 111 subjects, 48 males and 63 females, with a mean age of 12.6 years. The patients had ...
Rocha Uéslen - - 2013
In this work we report on the multifunctional character of neodymium doped LaF3 core/shell nanoparticles. Because of the spectral overlap of the Neodymium emission bands with the transparency windows of human tissues, these nanoparticles emerge as relevant sub-tissue optical probes. For Neodymium contents optimizing the luminescence brightness of Nd3+:LaF3 nanoparticles, ...
Zaki Jamil - - 2013
Although altruistic and selfish behaviors seem fundamentally incommensurate, humans regularly choose between them. One model of such choices suggests that individuals ascribe a common form of subjective value to their own outcomes and those of others. To test this person invariance hypothesis, we asked individuals to choose between allocating varying ...
Thirugnanasambantham Krishnaraj - - 2013
Bud dormancy is of ecological and economical interest due to its impact on tea (Camellia sinensis (L.) O. Kuntze) plant growth and yield. Growth regulation associated with dormancy is an essential element in plant's life cycle that leads to changes in expression of large number of genes. In order to ...
Oemisch Luise - - 2013
Experimental determination of oil-water partition coefficients often poses difficulties associated with emulsion formation. The aim of this work was to find an appropriate technique for determination of oil-water partition coefficients of polar, nonvolatile compounds. Two different methods were tested. The first method used a "silicone membrane equilibrator." For the second ...
Gordon Christopher T - - 2013
BACKGROUND: Auriculocondylar syndrome (ACS) is a rare craniofacial disorder consisting of micrognathia, mandibular condyle hypoplasia and a specific malformation of the ear at the junction between the lobe and helix. Missense heterozygous mutations in the phospholipase C, β 4 (PLCB4) and guanine nucleotide binding protein (G protein), α inhibiting activity ...
Sipahi Savas - - 2013
ABSTRACT: BACKGROUND: Diabetes is an important reason for end-stage renal failure and diabetic foot wounds worsen the life qualities of these patients. Protein and amino acid support accelerates the wound healing. The purpose of this retrospective study is to examine the effect of beta-hydroxy-beta-methylbutyrate, arginine and glutamine (Abound(R)) supplementation on ...
Werner K T - - 2013
BACKGROUND: The prevalence of portal vein thrombosis (PVT) increases with the severity of liver disease. Development of PVT is often accompanied by increased rate of morbidity and mortality and may affect patient candidacy for liver transplant. There is limited data regarding the role of anticoagulation therapy in patients with PVT ...
Sobocki Jacek - - 2013
BACKGROUND: Autonomic and vagal neuromodulation has been suggested for the treatment of morbid obesity. Occipital nerves remain in close anatomical relation to vagal nerve roots at the entrance to medulla oblongata. The aim of the study was to evaluate the effect of C1-C2 occipital neuromodulation on autonomic activity, body mass, ...
Kretschmer Lutz - - 2013
BACKGROUND: The value of a preoperative lymphoscintigraphy in melanoma patients with clinically evident regional lymph node metastases has not been studied. Therapeutic lymph node dissection (TLND) is regarded as the clinical standard, but the appropriate extent of TLND is controversial in all lymphatic basins. PATIENTS AND METHODS: Of the 115 ...
Ayati Adile - - 2013
A series of thiazoline-incorporated chalconoids, designed based on natural product scaffold, were efficiently synthesized via the reaction of 3-methyl-4-arylthiazole-2(3[Formula: see text])-thiones and appropriate phenacyl halides, and subsequent desulfurization. The starting 3-methyl-4- arylthiazole-2(3[Formula: see text])-thiones were also prepared from phenacyl halides. The structural aspects and ([Formula: see text])-geometry of compounds were ...
Toth Ildiko - - 2013
Mortality due to septic-shock-induced respiratory failure remains high. A recent meta-analysis suggested that IgM-enriched immunoglobulin treatment may be beneficial in these patients. In this prospective randomised controlled pilot study we investigated the effects of IgM-enriched immunoglobulin treatment in patients with early septic shock accompanied by severe respiratory failure. 33 patients ...
Brendler C - - 2013
Laser-based ion mobility (IM) spectrometry was used for the detection of neuroleptics and PAH. A gas chromatograph was connected to the IM spectrometer in order to investigate compounds with low vapour pressure. The substances were ionized by resonant two-photon ionization at the wavelengths λ = 213 and 266 nm and pulse energies between ...
Yan Xin-Long - - 2013
Recent evidence indicates that cancer-associated mesenchymal stem cells (MSCs) play a pivotal role in modulating tumor progression. However, the interactions between liver cancer-associated MSCs (LC-MSCs) and hepatocellular carcinoma (HCC) remain unreported. Here, for the first time, we identified the presence of MSCs in HCC tissues. We also showed that LC-MSCs ...
Bhide Alka A - - 2013
A biomarker is an indicator of a particular disease. It is generally used to define the presence (diagnostic biomarker), severity, progression (prognostic biomarker) of a condition and/or its response to a specific treatment (predictive biomarker). Biomarkers can be specific cells, enzymes, hormones, genes or gene products, which can be detected ...
Williams Teresa A - - 2013
AIMS AND OBJECTIVES: To develop and test strategies to reduce interruptions to enteral feeding to improve practice and promote attainment of nutritional goals. BACKGROUND: Enteral nutrition is preferred for feeding patients in the intensive care unit who are unable to have oral nutrition. Interruption to feeding is likely to be ...
Beaulieu Robert - - 2013
INTRODUCTION: Management of fistula-in-ano requires understanding of both perianal and rectal anatomy, as well as the surgical approaches available to ensure the highest possible postoperative continence and wound healing. Further, high rates of recurrence with medical management commonly bring these patients under the care of the colorectal surgeon after variable ...
Theveneau Eric - - 2013
Directional cell migration is required for proper embryogenesis, immunity, and healing, and its underpinning regulatory mechanisms are often hijacked during diseases such as chronic inflammations and cancer metastasis. Studies on migratory epithelial tissues have revealed that cells can move as a collective group with shared responsibilities. First thought to be ...
Liu Wen-Xiu - - 2013
The levels of organochlorine pesticides (OCPs) in the water, suspended solids, and sediments from Lake Chaohu during the high water level period were measured by a solid-phase extraction gas chromatograph-electron capture detector. The spatial distributions of the three phases and the water/suspended solids and sediment/water partition coefficients were analyzed. The ...
Giovacchini Giampiero - - 2013
PURPOSE: Myocardial ischaemia is frequently silent in patients with type 2 diabetes. Although it has been proposed as a potential screening tool, the role of myocardial perfusion single photon emission computed tomography (MPS) has recently been questioned, due to the low prevalence of positive scans and the low rate of ...
Neu Volker - - 2013
A reaction scheme was derived for the thermal degradation of thyroxine in the solid state using data obtained from ultrahigh-performance liquid chromatography and high-resolution mass spectrometry (UHPLC-HRMS). For studying the reaction mechanism and kinetics of the thermal degradation of the pharmaceutical in the solid state, a workflow was developed by ...
Holly Alice C - - 2013
We have previously described a statistical model capable of distinguishing young (age<65yrs) from old (age≥75yrs) individuals. Here we studied the performance of a modified model in three populations and determined whether individuals predicted to be biologically younger than their chronological age had biochemical and functional measures consistent with a younger ...
Bellés Montserrat - - 2013
The purpose of this study was to determine the daily dietary intake of uranium (U) by the general population of Catalonia, Spain. Uranium concentrations were measured in foods widely consumed by the population living in that autonomous community. Food samples were randomly acquired in 12 representative cities of Catalonia. The ...
Knerr Wendy - - 2013
Family and youth violence are increasingly recognized as key public health issues in developing countries. Parenting interventions form an important evidence-based strategy for preventing violence, both against and by children, yet most rigorous trials of parenting interventions have been conducted in high-income countries, with far fewer in low- and middle-income ...
Mapelli P - - 2013
PURPOSE: Gestational trophoblastic neoplasia (GTN) is a rare and aggressive tumour that is usually sensitive to chemotherapy. The usefulness of conventional imaging modalities in evaluating treatment response is limited, mainly due to the difficulty in differentiating between residual tumour tissue and necrosis. The aim of the present study was to ...
Daghistani Razan - - 2013
INTRODUCTION: Dysembryoplastic neuroepithelial tumors (DNET) are classically considered as benign, cortically based tumors that are stable. However, there were case reports that suggested DNET may not be as benign as previously thought. The purpose of our study was to identify atypical location, characteristics, and behavior of DNET in children. METHODS: ...
Vivekanandan-Giri Anuradha - - 2013
OBJECTIVE: Phagocyte-derived myeloperoxidase (MPO) and pro-inflammatory high density lipoprotein (HDL) associate with rheumatoid arthritis (RA), but the link between MPO and HDL has not been systematically examined. In this study, we investigated whether MPO can oxidise HDL and determined MPO-specific oxidative signature by apoA-1 by peptide mapping in RA subjects ...
Sakai Tsutomu - - 2013
OBJECTIVE: To evaluate the changes in health-related and vision-related quality of life (HR-QoL and VR-QoL) in patients with Behçet uveitis (BU) receiving infliximab therapy. METHODS: Twenty patients with recurrent BU attacks were enrolled. All patients were treated with infliximab. We evaluated the mean number of uveitis attacks and the mean ...
Kusz-Zamelczyk Kamila - - 2013
BACKGROUND: The Nanos gene is a key translational regulator of specific mRNAs involved in Drosophila germ cell development. Disruption of mammalian homologues, Nanos2 or Nanos3, causes male infertility in mice. In humans, however, no evidence of NANOS2 or NANOS3 mutations causing male infertility has been reported. Although Nanos1 seems dispensable ...
Healy Donagh A - - 2013
BACKGROUND: Full-body CT scanning is increasingly being used in the initial evaluation of severely injured patients. We sought to analyse the literature to determine the benefits of full-body scanning in terms of mortality and length of time spent in the emergency department (ED). METHODS: A systematic search of the Pubmed ...
Vazquez Rodriguez Gabriela - - 2013
Angiogenesis has been considered an important target for cancer therapy. The inhibition of angiogenesis represents a promising strategy for anti-cancer treatment, tumor growth inhibition, and metastasis. Vasostatin 30 (Vs30), and the 14.1 kDa vasoinhibin (Vi-II-14.1) are two peptides with remarkable anti-tumor and anti-angiogenic effect. The aim of this study was to ...
Warschkow Rene - - 2013
While LRYGB has become a cornerstone in the surgical treatment of morbidly obese patients, concomitant cholecystectomy during LRYGB remains a matter of debate. The aim of this meta-analysis was to estimate the rate and morbidity of subsequent cholecystectomy after laparoscopic Roux-en-Y gastric bypass (LRYGB) in obese patients. A meta-analysis was ...
Van Gosen Bradley S - - 2013
Erionite, a mineral series within the zeolite group, is classified as a Group 1 known respiratory carcinogen. This designation resulted from extremely high incidences of mesothelioma discovered in three small villages from the Cappadocia region of Turkey, where the disease was linked to environmental exposures to fibrous forms of erionite. ...
Ma Yi-Shih - - 2013
Crude extract of Rheum palmatum L (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the effects of CERP on LS1034 human colorectal cancer cells in vitro and also examined possible mechanisms of cell death. Flow cytometric assays were used ...
Yang Dan - - 2013
A facile thermal decomposing method has been developed for the fabrication of CoxP nanostructures with controlled size, phase and shape (e.g. Co2P rod and spheres, CoP hollow and solid particles). An amorphous carbon layer could be introduced by the carbonization of organic surfactants from the precursors. The electrochemical performance of ...
Bluguermann Carolina - - 2013
Mesenchymal stem or stromal cells (MSCs) were initially isolated from the bone marrow and received their name on the basis of their ability to differentiate into multiple lineages such as bone, cartilage, fat and muscle. However, more recent studies suggest that MSCs residing in perivascular compartments of the small and ...
Zhang Chengjun - - 2013
SUMMARY: gKaKs is a codon-based genome level Ka/Ks computation pipeline developed and based on programs from four widely used packages: BLAT, BLASTALL (including bl2seq, formatdb and fastacmd), PAML (including codeml and yn00) and KaKs_Calculator (including 10 substitution rate estimation methods). gKaKs can automatically detect and eliminate frame-shift mutations and premature ...
Mumm Patrick - - 2013
Anion transporters in plants play a fundamental role in volume regulation and signaling. Currently, two plasma membrane located anion channel families - SLAC/SLAH and ALMT - are known. Among the ALMT family the root expressed ALuminium-activated Malate Transporter 1 was identified by a comparative screen between aluminum-tolerant and Al(3+)-sensitive wheat ...
Fareri Dominic S - - 2013
Social interactions occur within a variety of different contexts-cooperative/competitive-and often involve members of our social network. Here we investigated whether social network modulated the value placed on positive outcomes during a competitive context. Eighteen human participants played a simple card-guessing game with three different competitors: a close friend (in-network), a ...
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