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Ganeshan Veena V Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY 14642, - - 2013
Neuroblastoma is a common, frequently fatal, neural crest tumor of childhood. Chemotherapy-resistant neuroblastoma cells typically have Schwann cell-like ("S-type") morphology and express the p75 neurotrophin receptor (p75NTR). p75NTR has been previously shown to modulate the redox state of neural crest tumor cells. We, therefore, hypothesized that p75NTR expression level would ...
Ko Je Yeong JY From the Department of Biological Science, Sookmyung Women's University, Seoul 140-742, Republic of - - 2013
Cilia in ciliated cells consist of protruding structures that sense mechanical and chemical signals from the extracellular environment. Cilia are assembled with variety molecules via a process known as intraflagellar transport (IFT). What controls the length of cilia in ciliated cells is critical to understand ciliary disease such as autosomal ...
Liang Zhong Z WM Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, - - 2013
A skin-tropic invasive group A Streptococcus pyogenes (GAS) strain, AP53, contains a natural inactivating mutation in the covS gene (covS(M)) of the two-component responder (CovR)/sensor (CovS) gene regulatory system. The effects of this mutation on specific GAS virulence determinants have been assessed, with emphasis on expression of the extracellular protease, ...
Beltramo Riccardo R Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, - - 2013
In the absence of external stimuli, the mammalian neocortex shows intrinsic network oscillations. These dynamics are characterized by translaminar assemblies of neurons whose activity synchronizes rhythmically in space and time. How different cortical layers influence the formation of these spontaneous cellular assemblies is poorly understood. We found that excitatory neurons ...
Krey Jocelyn F JF Department of Neurobiology, Stanford University School of Medicine, Stanford, California, - - 2013
L-type voltage gated calcium channels have an important role in neuronal development by promoting dendritic growth and arborization. A point mutation in the gene encoding Ca(V)1.2 causes Timothy syndrome, a neurodevelopmental disorder associated with autism spectrum disorders (ASDs). We report that channels with the Timothy syndrome alteration cause activity-dependent dendrite ...
Gomez Delphine D Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, - - 2013
Chromatin immunoprecipitation assays have contributed greatly to our understanding of the role of histone modifications in gene regulation. However, they do not permit analysis with single-cell resolution, thus confounding analyses of heterogeneous cell populations. Here we present a method that permits visualization of histone modifications of single genomic loci with ...
Kornblum Cornelia C Department of Neurology, University of Bonn Medical Center, Bonn, - - 2013
Known disease mechanisms in mitochondrial DNA (mtDNA) maintenance disorders alter either the mitochondrial replication machinery (POLG, POLG2 and C10orf2) or the biosynthesis pathways of deoxyribonucleoside 5'-triphosphates for mtDNA synthesis. However, in many of these disorders, the underlying genetic defect has yet to be discovered. Here, we identify homozygous nonsense and ...
Hamasaki Yuko Y Department of Nephrology, Tokyo Metropolitan Children's Medical Center, Fuchu, Japan. - - 2013
Cyclosporine has improved remission rates in children with steroid-resistant nephrotic syndrome (SRNS). However, little prospective long-term follow-up data is available. We prospectively followed and analyzed 5-year outcomes of all 35 patients enrolled in our previous prospective multicenter trial with cyclosporine and steroids in children with SRNS. At enrollment, 23 cases ...
Antonarakis Emmanuel S ES Prostate Cancer Research Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB1-1M45, Baltimore, MD 21231-1000, USA. - - 2013
KX2-391 is an oral non-ATP-competitive inhibitor of Src kinase and tubulin polymerization. In phase 1 trials, prostate-specific antigen (PSA) declines were seen in patients with advanced prostate cancer. We conducted a single-arm phase 2 study evaluating KX2-391 in men with chemotherapy-naïve bone-metastatic castration-resistant prostate cancer (CRPC). We treated 31 patients ...
Gora Michalina J MJ Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, - - 2013
Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 μm (lateral) × 7 μm (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural ...
Lyons Nicholas A NA Department of Physiology, University of California, San Francisco, San Francisco, California, - - 2013
Sister-chromatid cohesion is established during S phase when Eco1 acetylates cohesin. In budding yeast, Eco1 activity falls after S phase due to Cdk1-dependent phosphorylation, which triggers ubiquitination by SCF(Cdc4). We show here that Eco1 degradation requires the sequential actions of Cdk1 and two additional kinases, Cdc7-Dbf4 and the GSK-3 homolog ...
Lapkouski Mikalai M Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, - - 2013
Hundreds of structures of type 1 human immunodeficiency virus (HIV-1) reverse transcriptase (RT) have been determined, but only one contains an RNA/DNA hybrid. Here we report three structures of HIV-1 RT complexed with a non-nucleotide RT inhibitor (NNRTI) and an RNA/DNA hybrid. In the presence of an NNRTI, the RNA/DNA ...
Chmielecki Juliann J Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, - - 2013
Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this ...
Trenholm Stuart S Department of Biology, University of Victoria, Victoria, British Columbia, - - 2013
Moving objects can cover large distances while they are processed by the eye, usually resulting in a spatially lagged retinal response. We identified a network of electrically coupled motion-coding neurons in mouse retina that act collectively to register the leading edges of moving objects at a nearly constant spatial location, ...
Sciascia Savino - - 2013
Objective. To develop and validate a risk score [global APS score (GAPSS)] derived from the combination of independent risk for thrombosis and pregnancy loss (PL), taking into account the aPL profile, conventional cardiovascular risk factors and the autoimmune antibody profile.Methods. This cross-sectional study included 211 consecutive SLE patients. Data on ...
Eckardt J - - 2013
Osteogenesis imperfecta (OI) is a genetic disorder causing defects in the development of collagen type I. Clinical signs of affected dachshunds include multiple fractures of bones, joint hyperlaxity and dentinogenesis imperfecta. Recently, a recessive mutation in the SERPINH1 gene was detected in dachshunds and enabled the development of a DNA ...
Delgado Almandoz Josser E - - 2013
BACKGROUND: There is wide variability in the reported incidence of perioperative thromboembolic (0-14%) and hemorrhagic (0-11%) complications after Pipeline Embolization Device (PED) procedures for cerebral aneurysm treatment, which could be partly due to differences in patient response to the P2Y12 receptor antagonist administered while the PED endothelializes. This study aims ...
Ramirez-Moreno David F - - 2013
This work proposes a model of visual bottom-up attention for dynamic scene analysis. Our work adds motion saliency calculations to a neural network model with realistic temporal dynamics [(e.g., building motion salience on top of De Brecht and Saiki Neural Networks 19:1467-1474, (2006)]. The resulting network elicits strong transient responses ...
Avendano Carlos - - 2013
In the first paper of this series [C. Avendaño et al. J. Phys. Chem. B 2011, 115, 11154] we introduced the SAFT-g force field for molecular simulation of fluids. In our approach a molecular-based equation of state (EoS) is used to obtain coarse-grained (CG) intermolecular potentials that can be used ...
Mungrue Kameel - - 2013
Abstract Background: The aim of this study is to measure the occurrences of the following risk factors: tobacco use, levels of physical activity, levels of physical inactivity, and body mass index (BMI) among adolescents in Trinidad. Methods: A two-stage random sampling process was used to select schools and students. Data ...
Dhanasekaran M - - 2013
Current protocols of islet cell transplantation for the treatment of diabetes mellitus have been hampered by islet availability and allograft rejection. Although bone marrow and subcutaneous adipose tissue stem cells feature their tissue repair efficacy, applicability of stem cells from various sources is being researched to develop a promising therapy ...
Taher Leena Yaseen - - 2013
Aggressive fibromatosis is a benign but locally-aggressive tumor, which most often affects the muscles of the shoulder, the pelvic girdle, and the thigh. It usually affects adolescents and young adults. Desmoplastic fibroma, considered the bone counterpart of soft tissue fibromatosis, is a rare tumor that usually affects the metaphyseal or ...
Oriá Arianne P - - 2013
BACKGROUND: The accumulation of pus in the orbit originating from an infected dental root is classified as odontogenic intraorbital abscess. METHODS: Clinical, laboratory, and image evaluation of a non-human primate was performed. RESULTS: The patient was cured after surgical therapy. CONCLUSIONS: This represents the first report of an odontogenic periodontal ...
Boonyagul Sani - - 2013
Aloe vera is a traditional wound healing medicine. We hypothesized acemannan, a polysaccharide extracted from Aloe vera gel, could affect bone formation. Primary rat bone marrow stromal cells (BMSCs) were treated with various concentrations of acemannan. New DNA synthesis, VEGF, BMP-2, alkaline phosphatase activity, bone sialoprotein, osteopontin expression, and mineralization ...
Arnson Yoav - - 2013
Myocardial infarction (MI) is the most common cause of cardiac injury in the Western world. Cardiac injury activates innate immune mechanisms initiating an inflammatory reaction. Inflammatory cytokines and vascular cell adhesion molecules (VCAM) promote adhesive interactions between leukocytes and endothelial cells, resulting in the transmigration of inflammatory cells into the ...
Yeh Kuo-Wei - - 2013
This population-based study aimed to determine the trend of incidence, prevalence, and mortality of systemic lupus erythematosus (SLE) in a 6-year period in Taiwan. Patients with international classification of diseases ninth revision (ICD-9) code 710.0 were retrieved from the Taiwanese National Health Insurance Research Database (NHIRD), which covered more than ...
Hosseini Morteza Tavakkoli - - 2013
ABSTRACT: We present a case of surgical implantation of biventricular epicardial pacing leads and a defibrillating patch via lower half mini sternotomy. Although median sternotomy is routinely used for this purpose, lower half mini sternotomy could provide the surgeon with the same surgical field exposure and a faster post operative ...
Trollvik Anne - - 2013
AIM AND OBJECTIVES: To explore the participation and responses of children to an asthma education programme that was developed with the aid of children with asthma. In a larger perspective, the aim was to understand how educational approaches can be designed to help children learn to live and cope with ...
Carney Kerrilynn - - 2013
Although injection drug use (IDU) and blood transfusions prior to 1992 are well-accepted risk factors for hepatitis C virus (HCV) infection, many prior studies that have evaluated tattooing as a risk factor for HCV infection did not control for a history of IDU or transfusion prior to 1992. In this ...
Lehnert Michael - - 2013
The bio-modification of surfaces especially titanium, is an important issue in current biomedical research. Regarding titanium, it is also important to ensure a specific protein modification of its surface, because here too random protein binding can be observed. Specific nanoscale architectures can be applied to overcome this problem. As recently ...
Willie Christopher K - - 2013
The post-exercise period is associated with hypotension, and an increased risk of syncope attributed to decreases in venous return and/or vascular resistance. Increased local and systemic vasodilators, sympatholysis, and attenuated baroreflex sensitivity following exercise are also manifest. Although resting cerebral blood flow is maintained, cerebrovascular regulation to acute decreases in ...
Carpenter Delesha M - - 2013
The primary purpose of this article is to document whether demographic, clinical, regimen-related, intrapersonal, and interpersonal factors predict medication non-adherence for vasculitis patients. A secondary purpose is to explore whether adherence varies by medication type and whether patients experienced drug-related side effects. Vasculitis patients (n = 228) completed online baseline and 3-month ...
Ryan P - - 2013
Little is known about the dimensions of osteoporosis prevention programs essential to changing health behaviors. The purpose of this review was to determine the impact of select characteristics of structured osteoporosis prevention programs on calcium intake in women. This systematic review included 12 experimental and quasi-experimental studies conducted internationally with ...
Patanwala Asad E - - 2013
OBJECTIVE: The primary objective of this study was to compare the analgesic response to morphine in non-obese, obese and morbidly obese patients for acute pain. METHODS: This was a retrospective cohort study conducted in a tertiary care emergency department in the USA. Consecutive adults who received intravenous morphine 4 mg ...
Dogan Vehbi - - 2013
The aim of our study was to evaluate myocardial functions with strain/strain rate echocardiography in asymptomatic patients having congenital aortic stenosis (CAS) with normal cardiac functions as determined by conventional echocardiographic techniques and comparing them with those of healthy controls. A total of 58 patients with various degrees of isolated ...
Présumey Jessy - - 2013
OBJECTIVES: Nicotinamide phosphoribosyltransferase (NAMPT)/pre-B-cell colony-enhancing factor/visfatin exerts multiple functions and has been implicated in the pathogenesis of rheumatoid arthritis. To gain insight into its role in arthritis and given that NAMPT is identified as a novel mediator of innate immunity, we addressed the function of monocyte-derived NAMPT in experimental arthritis ...
Al-Shamsi Mariam - - 2013
ABSTRACT: BACKGROUND: A novel in vitro system was employed to investigate liver tissue respiration (mitochondrial O2 consumption) in mice treated with concanavalin A (Con A). This study aimed to investigate hepatocyte bioenergetics in this well-studied hepatitis model. METHODS: C57Bl/6 and C57Bl/6 IFN-gamma-/- mice were injected intravenously with 12 mg ConA/kg. ...
Dallos Tomás - - 2013
Objective. Haemochromatosis arthropathy is a secondary OA and the most frequent and earliest clinical presentation of hereditary haemochromatosis (HH). The aim of this study was to perform a direct clinical, functional and radiographic comparison with idiopathic hand OA (HOA) to unravel important differences between these clinical entities.Methods. In total, 299 ...
Cho Kwang Ho - - 2013
OBJECTS: During ontogeny, part of Rathke's pouch, a physiologically superior pouching of the stomodeal ectoderm, may remain, forming the usual anomaly known as Rathke's cleft cyst. More rarely, however, the entire pouch (i.e., the craniopharyngeal canal) remains, resulting in transsphenoidal meningoencephalocele. This study is aimed to provide a better understanding ...
Cao Ran - - 2013
Abstract Background: Tetramethylpyrazine (TMP) is used to treat cerebrovascular and cardiovascular diseases. However, it displays a short half-life that restricts clinical applications. 2-Hydroxymethyl-3,5,6-trimethylpyrazine (HTMP) is the principal active metabolite of TMP, with similar activity of TMP. Therefore, it makes sense to improve the biopharmaceutical characteristics via HTMP bypassing TMP. Purpose: ...
Zittermann Armin - - 2013
AimsA significant proportion of cardiac surgical patients develop critical post-operative complications. We aimed to investigate the association of pre-operative 25-hydroxyvitamin D (25(OH)D) levels with major cardiac and cerebrovascular events (MACCE) in cardiac surgical patients.Methods and resultsFrom January 2010 to August 2011, we consecutively measured circulating 25(OH)D in 4418 operated patients. ...
Simal Julián Juan Antonio - - 2013
PURPOSE: Indocyanine green videoangiography (IGV) has proven its effectiveness in the field of exovascular neurosurgery, both in the intracranial and spinal compartment, but is necessary to define a systematic process for the performance of the IGV to facilitate its interpretation during the procedure. We have defined and applied the concept ...
Mata-Rocha Minerva - - 2013
CatSper channels are essential for hyperactivity of sperm flagellum, progesterone-mediated chemotaxis and oocyte fertilisation. Catsper genes are exclusively expressed in the testis during spermatogenesis, but the function and regulation of the corresponding promoter regions are unknown. Here, we report the cloning and characterization of the promoter regions in the human ...
Creswell J David - - 2013
Brief periods of unconscious thought have been shown to improve decision-making compared to making an immediate decision. We reveal a neural mechanism for unconscious thought in decision making using BOLD contrast fMRI. Participants (N=33) encoded information on a set of consumer products (e.g., 48 attributes describing 4 different cars), and ...
Nakazawa Harumasa - - 2013
A 51-year-old Japanese male underwent on-pump coronary artery bypass grafting surgery. After weaning from cardiopulmonary bypass (348 min), sudden bradycardia and hypotension occurred, followed by ventricular fibrillation. Although defibrillation and infusion of catecholamine restored sinus rhythm, transesophageal echocardiography demonstrated severely reduced contraction of both ventricles, and perioperative vascular spasm was suspected. ...
Tsoi Ho - - 2013
Polyglutamine (polyQ) diseases, including several types of spinocerebellar ataxias and Huntington's disease (HD), are dominantly inherited neurodegenerative disorders caused by the expansion of the glutamine-coding CAG repeat in the open reading frame of the disease gene. Apart from being translated to produce toxic elongated polyQ domain-containing disease proteins, transcribed expanded ...
Kulkarni Sneha A - - 2013
PURPOSE: To investigate the effects of the particle size and surface coating on the cellular uptake of the polymeric nanoparticles for drug delivery across the physiological drug barrier with emphasis on the gastrointestinal (GI) barrier for oral chemotherapy and the blood-brain barrier (BBB) for imaging and therapy of brain cancer. ...
Gorman Ng Melanie - - 2013
Background:Although dustiness and viscosity are potential determinants of dermal exposure, their effect on exposure is poorly understood. The goal of this study was to investigate the effect of dustiness and viscosity on dermal exposure by each of three dermal exposure pathways (deposition, surface contact, and immersion). METHODS: The hands of ...
Hvaring Christina L - - 2013
This study aimed to assess infraocclusion, root resorption and restorations and their importance for the prognosis of retained primary mandibular molars lacking successors. The sample comprised 188 persisting primary mandibular second molars in 111 subjects, 48 males and 63 females, with a mean age of 12.6 years. The patients had ...
Rocha Uéslen - - 2013
In this work we report on the multifunctional character of neodymium doped LaF3 core/shell nanoparticles. Because of the spectral overlap of the Neodymium emission bands with the transparency windows of human tissues, these nanoparticles emerge as relevant sub-tissue optical probes. For Neodymium contents optimizing the luminescence brightness of Nd3+:LaF3 nanoparticles, ...
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