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Salvatori Roberto - - 2013
Lanreotide depot (LD; commercial name Somatuline(®) Depot) is an injectable, extended-release formulation of the synthetic somatostatin analog (SSA) lanreotide. In recent clinical trials, LD was found to be suitable for self or partner administration, avoiding the need to travel to a medical facility. The Somatuline(®) Depot for Acromegaly (SODA) study ...
Acharya Deepak - - 2013
Hemolysis is a potential complication of mitral valve repair. We report a case of hemolytic anemia after mitral valve repair successfully treated with re-repair, and review the literature on reoperation after failure of mitral valve repair with associated hemolysis.
Luxán Guillermo G Program of Cardiovascular Developmental Biology, Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares, Madrid, - - 2013
Left ventricular noncompaction (LVNC) causes prominent ventricular trabeculations and reduces cardiac systolic function. The clinical presentation of LVNC ranges from asymptomatic to heart failure. We show that germline mutations in human MIB1 (mindbomb homolog 1), which encodes an E3 ubiquitin ligase that promotes endocytosis of the NOTCH ligands DELTA and ...
Stafford Kristen A - - 2013
INTRODUCTION: Cancer survivors are at increased risk for influenza-related complications. Racial disparities in preventive health services have not been extensively studied among cancer survivors. Our objective is to compare influenza vaccination prevalence among black and white cancer survivors METHODS: We performed a secondary data analysis of 41,346 white and black ...
Dileep Kalarickal Vijayan - - 2013
Phospholipase A2 (PLA(2)) is one of the key enzymes involved in the formation of inflammatory mediators. Inhibition of PLA(2) is considered to be one of the efficient methods to control inflammation. In silico docking studies of 160 selected indole derivatives performed against porcine pancreatic PLA(2) (ppsPLA(2)) suggested that, CID2324681, CID8617 ...
Yoneyama Takeshi - - 2013
Purpose For the application of less invasive robotic neurosurgery to the resection of deep-seated tumors, a prototype system of a force-detecting gripper with a flexible micromanipulator and force feedback to the operating unit will be developed. Methods Gripping force applied on the gripper is detected by strain gauges attached to ...
Long Mei-Rong - - 2013
A novel Gram-negative, aerobic, slightly halophilic, yellow-pigmented, oxidase-negative, Voges-Proskauer positive, non-spore-forming bacterium, designated YIM M 13059(T), was isolated from a sediment sample collected from the South China Sea at a depth of 310 m. Optimal growth was found to occur at 28-30 °C, pH 7.0 and in the presence of 3-4 % (w/v) ...
Wei Shu-Qin - - 2013
Abstract OBJECTIVE: To estimate the associations between maternal vitamin D status and adverse pregnancy outcomes. STUDY DESIGN: We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to October, 2012 using the following keywords: 'vitamin D' and 'status' or 'deficiency' or 'insufficiency' and 'pregnancy'. ...
Kadam Abhijeet B AB Lokmanya Tilak Medical College and General Hospital, Sion, Mumbai 400022, India. - - 2013
The purpose of the study was to propose a method of prone positioning for posterior cervico-dorsal spine surgeries that is easy to achieve without additional equipment and may reduce complications associated with prone positioning in patients. 41 patients underwent posterior spine surgeries using our method of prone positioning on a ...
da Rocha Marilene L - - 2013
α,β-Epoxy-carvone (EC) is a monoterpene found in the essential oils of many species of plants. It can also be obtained by organic synthesis. EC exerts a depressant effect on the central nervous system and is also known to have anticonvulsant, antimicrobial and antioxidant effects. The present study investigated the antinociceptive ...
Berhouma Rym - - 2013
Our study aimed to analyze whether the expression of PPARγ mRNA in subcutaneous adipocyte tissue correlates with Pro12Ala PPARγ2 polymorphism in the obesity context. We found that mRNA expression of PPARγ in subcutaneous adipose tissue was greater in obese subjects (P < 0.05) than in the nonobese control group. Concurrently, genotyping of ...
Feng Xueling - - 2013
Poly(ferrocenyl(3-bromopropyl)methylsilane) and poly(ethylene imine) are employed in a layer-by-layer deposition process to form covalently connected, redox-active multilayer thin films by means of an amine alkylation reaction. The stepwise buildup of these multilayers on silicon, ITO and quartz substrates was monitored by UV-Vis absorption spectroscopy, Fourier Transform infrared spectroscopy (FTIR), static ...
Magnusson Baldur P - - 2013
An important component of clinical trials in drug development is the analysis of treatment efficacy in patient subgroups (subpopulations). Because of concerns of multiplicity and of the small sample sizes often involved, such analyses can present substantial statistical challenges and may lead to misleading conclusions. As a confirmatory seamless phase ...
Mao Xiaoming - - 2013
Burgeoning experimental and simulation activity seeks to understand the existence of self-assembled colloidal structures that are not close-packed. Here we describe an analytical theory based on lattice dynamics and supported by experiments that reveals the fundamental role entropy can play in stabilizing open lattices. The entropy we consider is associated ...
Malik Archana - - 2013
To study the demographic profile, cause, type and severity of ocular injuries, their complications and final visual outcome following fireworks around the time of Deepawali in India. Case records of patients who presented with firework-related injuries during 2005-2009 at the time of Deepawali were reviewed. Data with respect to demographic ...
Ide Seiko - - 2013
Percutaneous coronary intervention for chronic total occlusion remains a challenging field for interventional cardiologists because of inability to advance a wire beyond the occlusion. In case that the wire is not crossed to the distal main vessel but a side branch originated from distal end of the occlusion, we applied ...
Burkhardt T - - 2013
INTRODUCTION: Dehydroepiandrosterone sulfate (DHEA(S)) is a multi-functional steroid implicated in a broad range of biological effects, including obesity, diabetes, bone metabolism, neuroprotection, and anti-tumorigenesis. It has not yet undergone wider research in the context of Cushing's disease. The objective of this study was to determine if perioperative blood levels of ...
Scheiter Maxi M Research Group Cellular Proteomics, Helmholtz Centre for Infection Research, HZI, Inhoffenstraβe 7, D-38124 Braunschweig, - - 2013
The recent Natural Killer (NK) cell maturation model postulates that CD34(+) hematopoietic stem cells (HSC) first develop into CD56(bright) NK cells, then into CD56(dim)CD57(-) and finally into terminally maturated CD56(dim)CD57(+). The molecular mechanisms of human NK cell differentiation and maturation however are incompletely characterized. Here we present a proteome analysis ...
Ran Lishan - - 2013
China, with the confrontation of water-related problems as an element of its long history, has been investing heavily in water engineering projects over the past few decades based on the assumption that these projects can solve its water problems. However, the anticipated benefits did not really occur, or at least ...
Frossard Aline - - 2013
Successional changes of terrestrial vegetation can profoundly influence stream ecosystem structure and function. We hypothesized that microbial enzyme production and community structure in stream beds depend on terrestrial litter inputs reflecting different stages of riparian succession. Outdoor experimental channels were supplied with leaf-litter of varying quantities and qualities to mimic ...
Liang Zhong Z WM Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, - - 2013
A skin-tropic invasive group A Streptococcus pyogenes (GAS) strain, AP53, contains a natural inactivating mutation in the covS gene (covS(M)) of the two-component responder (CovR)/sensor (CovS) gene regulatory system. The effects of this mutation on specific GAS virulence determinants have been assessed, with emphasis on expression of the extracellular protease, ...
Sahraei R - - 2013
In this paper, a new spectrophotometric method is reported for the determination of nanomolar levels of Eriochrome black T in environmental samples. The method is based on the catalytic effect of silver nanoparticles on the oxidation of Eriochrome black T by hexacyanoferrate (III) in acetate-acetic acid medium and at 25 °C. ...
Zhang Mingyang - - 2013
Cystathionine-β-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration. It was reported that CBS was a novel marker of both differentiation and proliferation for certain cell types, suggesting that CBS ...
Ranzani Marco - - 2013
Transposons and γ-retroviruses have been efficiently used as insertional mutagens in different tissues to identify molecular culprits of cancer. However, these systems are characterized by recurring integrations that accumulate in tumor cells and that hamper the identification of early cancer-driving events among bystander and progression-related events. We developed an insertional ...
Gadwala Mallikarjun - - 2013
The outstanding capability of two-dimensional gel electrophoresis in separating all types of proteins basically depends on the efficiency of sample preparation. Sample preparation is one of the most critical steps in two-dimensional gel electrophoresis. Unfortunately, due to severe solubility, resolution of protein on gel is usually hampered, and thus, analysis ...
Hamasaki Yuko Y Department of Nephrology, Tokyo Metropolitan Children's Medical Center, Fuchu, Japan. - - 2013
Cyclosporine has improved remission rates in children with steroid-resistant nephrotic syndrome (SRNS). However, little prospective long-term follow-up data is available. We prospectively followed and analyzed 5-year outcomes of all 35 patients enrolled in our previous prospective multicenter trial with cyclosporine and steroids in children with SRNS. At enrollment, 23 cases ...
Chen Wei-Feng - - 2013
PURPOSE: Colorectal cancer is a common malignancy and one of the major causes of cancer-related deaths worldwide. Similar to other human cancers, tumor metastasis is the biggest obstacle in the clinical treatment of colorectal cancer. In this study, we explored the functional role of SLIT2 in colon tumor metastasis and ...
Parpaleix Alexandre - - 2013
Two-photon phosphorescence lifetime microscopy (2PLM) has been used recently for depth measurements of oxygen partial pressure (PO(2)) in the rodent brain. In capillaries of olfactory bulb glomeruli, 2PLM has also allowed simultaneous measurements of PO(2) and blood flow and revealed the presence of erythrocyte-associated transients (EATs), which are PO(2) gradients ...
Jiang Xiaolong X Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville, Virginia, - - 2013
Deciphering the interneuronal circuitry is central to understanding brain functions, yet it remains a challenging task in neurobiology. Using simultaneous quadruple-octuple in vitro and dual in vivo whole-cell recordings, we found two previously unknown interneuronal circuits that link cortical layer 1-3 (L1-3) interneurons and L5 pyramidal neurons in the rat ...
Scholte Ron H J - - 2013
Previous studies on victimization have either used self-reports of peer-reports, but correspondence between these measures is low, implying that types of victims may exist that differ in convergence between self- and peer-reported victimization. Importantly, the very few studies that do exist on such types were cross-sectional, and did not address ...
Lin Hao Daniel - - 2013
Hematopoietic stem cells (HSCs) from umbilical cord blood have been successfully used to treat blood disorders but one major hurdle is the relatively low cell dose available. Double cord blood unit transplantation results in elevated engraftment failure because one unit predominates over the other. Various approaches are thus being undertaken ...
Iloro Ibon - - 2013
An access to fast and non-invasive techniques to infer or predict the drug-induced injury caused by newly developed drugs and to monitor therapeutic efficacy of established drugs during treatment are of the outmost importance in pharmaceutical industry and clinical diagnosis. Peptidome and low molecular weight proteome profiling is an emerging ...
Glendor Ulf - - 2013
BACKGROUND/AIM: The yearly cost of sports injuries, which affects Swedish society, is estimated to 3 billion SEK (460 million USD). Injuries in ice hockey represent at least 270 million SEK (42 million USD). Despite the high number of injuries, mouth and face guards are rarely used in Swedish ice hockey. The ...
Leisso Rachel - - 2013
The transition from cold storage to ambient temperature alters apple quality through accelerated softening, flavor and color changes, and development of physiological peel disorders, such as superficial scald, in susceptible cultivars. To reveal global metabolism associated with this transition, the 'Granny Smith' peel metabolome was evaluated during storage of 6 ...
Shi Jingchun - - 2013
Marine edible fish samples were collected from two important nearshore fishing sites in the eastern Guangdong Province, China: Shantou Harbor and Haimen Bay. In the mixed edible muscle tissues of marine fish samples, the concentrations of polychlorinated biphenyls, dichlorodiphenyltrichloroethanes (DDTs), hexachlorocyclohexanes (HCHs), chlordanes, and hexachlorobenzene ranged from 1.12 to 53.87, ...
Salgaonkar B B - - 2013
AIMS: Characterization of polyhydroxyalkanotes (PHA) accumulated by halophilic bacteria isolated from solar salterns. METHODS AND RESULTS: Twenty six halophilic isolates were obtained from solar salterns of Goa, India. They were screened for accumulation of PHA by Sudan black B, Nile blue A and Nile red stain. Strains H15, H16 and ...
Heiberg Turid - - 2013
OBJECTIVE: Patient-reported outcomes are important for clinical practice and research, and should reflect what patients perceive as important. The objective of this study was to develop and preliminarily validate a brief, patient-derived, disease-specific tool, the pancreatic cancer disease impact (PACADI) score. METHODS: The development was performed in two phases. Forty-one ...
Werner Achim - - 2013
Eps8, a bi-functional actin cytoskeleton remodeller, is a positive regulator of cell proliferation and motility. Here, we describe an unrecognized mechanism regulating Eps8 that is required for proper mitotic progression: whereas Eps8 is stable in G1 and S phase, its half-life drops sharply in G2. This requires G2-specific proteasomal degradation ...
Varettas Kerry - - 2013
Samples of allograft musculoskeletal tissue are cultured by bacteriology laboratories to determine the presence of bacteria and fungi. In Australia, this testing is performed by 6 TGA-licensed clinical bacteriology laboratories with samples received from 10 tissue banks. Culture methods of swab and tissue samples employ a combination of solid agar ...
Kankılıç Gökben Başaran - - 2013
In this study, the concentrations of 13 elements (Al, Fe, Mn, Cr, Ni, Zn, Co, As, Pb, Cu, Mo, Hg, and Cd) were determined in the sediments of three different sites in the Kapulukaya Dam Lake between May 2007 and November 2008. They ranged from 1.47 to 4.64 for Al, ...
Czuber-Dochan W - - 2013
Fatigue is a common and leading concern for patients with inflammatory bowel disease (IBD). It is managed inadequately in IBD, and there is little evidence to support interventions. To examine patients' experience of and factors contributing to IBD-fatigue, and to appraise its management by patients and healthcare professionals. Seven electronic ...
You Minsheng - - 2013
How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood. We report ...
Buizer-Voskamp Jacobine E - - 2013
Genomic copy number variations (CNVs) and increased parental age are both associated with the risk to develop a variety of clinical neuropsychiatric disorders such as autism, schizophrenia and bipolar disorder. At the same time, it has been shown that the rate of transmitted de novo single nucleotide mutations is increased ...
Chen Feng - - 2013
A catalytic asymmetric bromocyclization of tri-substituted olefinic amides is reported using a C2-symmetric mannitol-derived cyclic selenium catalyst and stoichiometric amount of N-bromophthalimide. The resulting enantioenriched pyrrolidine products, which contain two stereogenic centers, could undergo rearrangement to yield 2,3-disubstituted piperidine in excellent diastereoselectivity and enantiospecificity.
Ali Farah N - - 2013
BACKGROUND: Acute kidney injury (AKI) carries a large burden of morbidity and mortality. Early diagnosis may lead to better strategies of clinical care. Cardiac surgery involving cardiopulmonary bypass is associated with a significant incidence of AKI. The study objective was to determine whether or not preoperative fibroblast growth factor-23 (FGF23) ...
Ostergaard Peter J - - 2013
Abstract Accurate histological quantification of astrocytosis after cerebral infarction is needed as this process may affect, and be affected by, many potential restorative treatments under investigation. We performed a systematic review to determine the most reliable histological method reported for measurement of post-infarction astrocytosis. We found reports of multiple techniques ...
Vishnivetskaya Tatiana A - - 2013
The efficiency of a novel integrated treatment system for biological removal of ammonium, nitrite, nitrate, and heavy metals from fossil power plant effluent was evaluated. Microbial communities were analyzed using bacterial and archaeal 16S rRNA gene clone libraries (Sanger sequences) and 454 pyrosequencing technology. While seasonal changes in microbial community ...
Krey Jocelyn F JF Department of Neurobiology, Stanford University School of Medicine, Stanford, California, - - 2013
L-type voltage gated calcium channels have an important role in neuronal development by promoting dendritic growth and arborization. A point mutation in the gene encoding Ca(V)1.2 causes Timothy syndrome, a neurodevelopmental disorder associated with autism spectrum disorders (ASDs). We report that channels with the Timothy syndrome alteration cause activity-dependent dendrite ...
Kastelik Jack A - - 2013
Malignancy is one of the most common causes of pleural effusion. Malignant pleural effusion is defined by the presence of malignant cells in the pleural fluid. Development of malignant pleural effusion usually defines advanced malignancy. Pathophysiology of malignant pleural effusion is not fully understood and may involve complex interactions between ...
Gil-Albarova J - - 2013
The records of 4 children of under 14 years of age treated at our institution for traumatic sternoclavicular dislocation (SCJ) were reviewed. Closed reduction in posterior SCJ after computed tomography (CT) was successful as immediate procedure. For anterior SCJ instability, open reduction and SCJ reconstruction obtained satisfactory results. Conservative treatment of ...
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