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Results 401 - 450 of 3064
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Chung Dong-Hoon - - 2013
ABSTRACT: BACKGROUND: Human respiratory syncytial virus (hRSV) is a highly contagious pathogen and is the most common cause of bronchiolitis and pneumonia for infants and children under one year of age. Worldwide, greater than 33 million children under five years of age are affected by hRSV resulting in three million ...
Woyceichoski Iverson Ernani Cogo - - 2013
Aim:  Crack cocaine is the freebase form of cocaine that can be smoked. The use of this drug has been considered a public health problem in many countries. The aim of this study was to assess the stimulated salivary flow rate (SSFR), pH, and the buffer capacity of saliva in ...
Tsuji Takeshi - - 2013
Results of very recent studies have shown that laser irradiation (LI) of colloidal nanoparticles (NPs) using a non-focused laser beam at moderate fluence transforms the NPs to submicron-sized spherical particles (SMPs). For this study, we applied this technique to prepare gold SMPs from source gold NPs prepared by laser ablation ...
Petersen B - - 2013
BACKGROUND: A great number of journeys to sunny destinations are sold to the Danish population every year. We suspect that this travel considerably increases personal annual ultraviolet radiation (UVR) exposure-dose. This is important because such exposure is the main cause of skin cancer, and studies have shown a correlation between ...
Stadler M - - 2013
BACKGROUND: In patients with type 1 diabetes mellitus (T1DM), insulin is usually replaced systemically (subcutaneously) and not via the physiologic portal route. According to previous studies, the liver's capacity to store glycogen is reduced in T1DM patients, but it is unclear whether this is due to hyperglycaemia, or whether the ...
Karaman Yucel - - 2013
SUMMARY: Following a propofol anesthetic, a 5-year-old girl with lower extremity spasticity seized and developed hypertriglyceridemia, hyperkalemia, and metabolic acidosis. A presumed diagnosis of propofol infusion syndrome (PRIS) was made, but further investigation revealed neonatal adrenoleukodystrophy. PRIS should be considered with this constellation of symptoms, but other neurometabolic disorders must ...
Xu Stanley S The Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA. - - 2013
In the examination of the association between vaccines and rare adverse events after vaccination in postlicensure observational studies, it is challenging to define appropriate risk windows because prelicensure RCTs provide little insight on the timing of specific adverse events. Past vaccine safety studies have often used prespecified risk windows based ...
Bogsrud Martin Prøven - - 2013
Objective. The aim of the present study was to evaluate the possible effects of Q10 and selenium supplementation on statin-induced myopathy (SIM), both for subjective symptoms and muscle function. Design. Patients (N = 43) who had experienced previous or ongoing SIM on atorvastatin therapy were recruited. Following a 6-week washout ...
Ahrens Brian D - - 2013
Isotope ratio mass spectrometry (IRMS) testing is performed to determine if an atypical steroid profile is due to administration of an endogenous steroid. Androsterone (Andro) and etiocholanolone (Etio), and/or the androstanediols (5α- and 5β-androstane-3α,17β-diol) are typically analyzed by IRMS to determine the (13) C/(12) C ratio. The ratios of these ...
Pedersen Vivi Kathrine - - 2013
Landscapes modified by glacial erosion show a distinct distribution of surface area with elevation (hypsometry). In particular, the height of these regions is influenced by climatic gradients controlling the altitude where glacial and periglacial processes are the most active, and as a result, surface area is focused just below the ...
Tang Dianping - - 2013
Recent research has looked to develop innovative, powerful and novel biofunctionalized nanoparticles, controlling and tailoring their properties in a very predictable manner to meet the needs of clinic immunoassays in the biomedical field. This minireview briefly summarizes recent advances covering the last 3 years, exploiting nanoparticle-based electrochemical, optical, mass-sensitive, colorimetric ...
Kraemer Helena Chmura - - 2013
No one treatment is likely to affect all patients with a disorder in the same way. A treatment highly effective for some may be ineffective or even harmful for others. Statistically significant or not, the effect sizes of many treatments tend to be small. Consequently, emphasis in clinical research is ...
Neff K J - - 2013
ABSTRACT: Obesity is recognized as a global health crisis. Bariatric surgery offers a treatment that can reduce weight, induce remission of obesity-related diseases, and improve the quality of life. In this article, we outline the different options in bariatric surgery and summarize the recommendations for selecting and assessing potential candidates ...
Papadimitriou Dimitrios T - - 2013
BACKROUND: With the recent knowledge of the possible involvement of 1,25-dihydroxyvitamin D in the pathogenesis of Type 1 Diabetes (T1D) and the results of its administration in animal models, we conducted a clinical trial by treating high-risk children, positive in autoantibodies for T1D, with oral calcitriol. METHODS: This prospective trial ...
Castaldelli-Maia João Mauricio - - 2013
Considering the absence of data on the appearance of drugs other than alcohol and tobacco in movie scenes, we decided to study the prevalence of portrayal of illicit drug use in a convenience sample of 50 Brazilian Movies. A total of 192 scenes (12h49'03(″)) meeting the inclusion criteria were identified ...
Wang Xindong - - 2013
A novel strategy was proposed for preparing a highly sensitive glycoprotein sensor based on molecularly imprinted polymers (MIP), which was electropolymerized with o-phenylenediamine and 3-aminophenylboronic acid monohydrate in the presence of template molecules (bovine serum albumin (BSA)). Sensitivity improved dramatically owing to the application of a graphene-Au nanoparticles hybrid as ...
Tsukamoto Megumi - - 2013
Many of the neurodegenerative diseases associated with a decrease in regional cerebral blood flow (rCBF) are untreatable, and the appropriate therapeutic strategy is to slow the progression of the disease. Therefore, it is important that a definitive diagnosis is made as soon as possible when such diseases are suspected. Diagnostic ...
Papp K A - - 2013
BACKGROUND: Long-term safety evaluations of biologics are needed to inform patient management decisions. OBJECTIVES: To evaluate the safety of ustekinumab in patients with moderate-to-severe psoriasis treated for up to five years. PATIENTS AND METHODS: Safety data were pooled from four studies of ustekinumab for psoriasis. Rates of adverse events (AEs), ...
Ghosh Asish K AK Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, - - 2013
Fibrosis, the hallmark of systemic sclerosis (SSc), is characterized by persistent fibroblast activation triggered by transforming growth factor-β (TGF-β). As the acetyltransferase p300 has a key role in fibrosis and its availability governs the intensity of fibrotic responses, we investigated p300 expression in SSc and the molecular basis of its ...
Fischer Jan - - 2013
Extracellular kallikrein-related peptidases (KLKs) are involved in the desquamation process and the initiation of epidermal inflammation by different mechanisms. Their action is tightly controlled by specific protease inhibitors. Recently, we have identified the serine protease inhibitor of Kazal-type (SPINK) 6 as a selective inhibitor of KLKs in human stratum corneum ...
Burden Christy - - 2013
OBJECTIVES: Prospective cohort study to assess the usability of virtual-reality (VR) simulation for obstetric ultrasound trainees. METHODS: Twenty-six participants were recruited; 18 obstetric ultrasound trainees (with little formal ultrasonography training) and eight certified experts. They all performed five sequential VR-simulated crown-rump length (CRL) scans in a single session and three ...
Saito Keiichi - - 2013
Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/MpJ-lpr/lpr (MRL-Fas(lpr)) mice and the expression of 6 ...
Jones-Webb Rhonda - - 2013
We contacted gay bar/club managers in 16 metropolitan statistical areas (MSAs) in the US from 2008 to 2010 and invited them to participate in survey of gay bar/club identification and patronage. The annual response rates were 58%, 74%, and 71%, respectively. We convened two, 1-hr meetings with research staff to ...
Kagiyama Megumi - - 2013
Strigolactones (SLs) are plant hormones that inhibit shoot branching. DWARF14 (D14) inhibits rice tillering and is an SL receptor candidate in the branching inhibition pathway, whereas the close homologue DWARF14-LIKE (D14L) participates in the signaling pathway of karrikins (KARs), which are derived from burnt vegetation as smoke stimulants of seed ...
Scott Daniel J - - 2013
ABSTRACT: BACKGROUND: The Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC-II) database is a free, publicresource for intensive care research. The database was officially released in 2006, and has attracted agrowing number of researchers in academia and industry. We present the two major software toolsthat facilitate accessing the relational database: ...
Jang Ji Woong - - 2013
BACKGROUND AND AIM: Comparatively little is known about acute pancreatitis or acute recurrent pancreatitis (AP/ARP) with intraductal papillary mucinous neoplasm of the pancreas (IPMN) as the causative lesion although there have been many reports about the malignant potential of IPMN as a premalignant lesion. METHODS: From 2000 to 2008, in ...
Whiteoak Christopher J - - 2013
An aluminium complex based on an amino triphenolate ligand scaffold shows unprecedented high activity (initial TOFs up to 36,000 h-1), substrate scope and functional group tolerance in the formation of highly functional organic carbonates prepared from epoxides and CO2. The developed catalytic protocol is further characterized by low catalyst loadings ...
Tunca Yusuf - - 2013
The coincidence of trisomy 21 and a structural rearrangement is very rare, and even it has not been reported as a prenatal diagnosis yet. In this article, we present an autosomal translocation carrier fetus with trisomy 21: 47,XX,+21, t(3;8)(p21;q24). Although the coincidence of reciprocal translocation and trisomy may be seen ...
Vera-Ramirez Laura - - 2013
Liver diseases pose a major medical problem worldwide and a wide variety of herbs have been studied for the management of liver-related diseases. In this respect, curcumin has long been used in traditional medicine, and in recent years it has been the object of increasing research interest. In combating liver ...
Orihuela Ruben - - 2013
Abstract The carcinogen inorganic arsenic (iAs) undergoes biomethylation (BMT) in some cells. The methylated metabolite, monomethylarsonous (MMA(3+)), may cause oxidative DNA damage (ODD). With chronic iAs exposure, BMT-competent cells show ODD while BMT-deficient do not. To further define these events, we studied ODD produced by acute iAs or MMA(3+) in ...
Riek Alexander - - 2013
A large number of analyses have examined how basal metabolic rate (BMR) is affected by body mass in mammals. By contrast, the critical ambient temperatures that define the thermo-neutral zone (TNZ), in which BMR is measured, have received much less attention. We provide the first phylogenetic analyses on scaling of ...
Laufer Yocheved - - 2013
There is still unsettled controversy regarding the optimal neuromuscular electrical stimulation (NMES) parameters that will induce the strongest contractions with minimal discomfort. The purpose of this study was to determine whether the introduction of an interphase interval (IPI) interposed within the two phases of biphasic pulses will affect sensory and ...
Lesniak Aleksandra B - - 2013
BACKGROUND: This retrospective cohort study was designed to assess the impact of intrathecal morphine compared with no intrathecal morphine on blood loss and on hemodynamic stability during surgery for pediatric idiopathic scoliosis correction. METHODS: A retrospective review was done of 256 anesthetic charts who underwent scoliosis surgery between January 1993 ...
Syed Farhatullah - - 2013
Mammalian target of rapamycin (mTOR) is essential in controlling several cellular functions. This pathway is dysregulated in keloid disease (KD). KD is a common fibroproliferative dermal lesion with an ill-defined treatment strategy. KD demonstrates excessive matrix deposition, angiogenesis, and inflammatory cell infiltration. In KD, both total and phosphorylated forms of ...
García Josefa Bernat - - 2013
Non-melanoma skin cancer (NMSC) is the most frequent malignancy in organ transplant recipients. The aetiology of NMSC after transplant is multifactorial. The aim of this study was to determine the clinical and environmen-tal factors involved in the development of NMSC in a Spanish kidney transplant population from the Mediterranean region. ...
Vogt Isabelle - - 2013
Fire blight is a destructive bacterial disease caused by Erwinia amylovora affecting plants in the family Rosaceae, including apple. Host resistance to fire blight is present mainly in accessions of Malus spp. and is thought to be quantitative in this pathosystem. In this study we analyzed the importance of the ...
Cruz Célia F - - 2013
Human hair has an important and undeniable relevance in society due to its important role in visual appearance and social communication. Hair is mainly composed of structural proteins, mainly keratin and keratin associated proteins, and lipids. Herein, we report a comprehensive study of the content and distribution of the lipids ...
Qin Andong - - 2013
Recent evidence showed that limited activation of PI3K/Akt pathway was critical for induction and function sustainment of CD4(+) Foxp3(+) regulatory T cells (Tregs). However, the underlying mechanism remains largely unknown. In this study, we reported that miR-126 was expressed in mouse and human Tregs. Further study showed that silencing of ...
Fustero Santos - - 2013
A gold-catalyzed tandem intramolecular hydroamination-formal aza-Diels-Alder reaction of propargylic amino esters is described. The overall process leads to the formation of a tetracyclic framework as a single diastereoisomer, with the creation of four bonds and five stereocenters.
Wang Wei - - 2013
The efficient asymmetric Michael addition reactions of aryl methyl ketones with 2-furanones were catalyzed by a simple and commercially available chiral 1,2-diphenyl-1,2-ethanediamine and p-TSA·H(2)O as cocatalyst with good yields (up to 95%) and excellent enantioselectivities (up to >99% ee). A bi-functional catalytic mechanism for the reaction was proposed.
Langstrup Henriette - - 2013
In this article I argue that attention to the spatial and material dimensions of chronic disease management and its place-making effects is necessary if we are to understand the implications of the increased mobilisation - technologically or otherwise - of the home in chronic disease management. Analysing home treatment in ...
Sydsjö Gunilla - - 2013
Objective. To evaluate the effect of a weight-gain restriction programme for obese pregnant women on sickness absence days and pregnancy benefit days during pregnancy and postpartum. Design. A prospective, controlled intervention study. The Swedish Social Security Agency's records were utilized to compile sickness absence and pregnancy benefit information. Setting. Antenatal ...
Eslamian Ladan - - 2013
Abstract Objectives: To study the effect of benzocaine mucoadhesive patches (20%) on orthodontic pain caused by elastomeric separators. Subjects and methods. A split-mouth design was used in 30 patients (12 female, 18 male, aged 23 ± 3.75 years). They were instructed to apply benzocaine and placebo patches randomly for right ...
Pateraki Irini - - 2013
Chromoplasts are non-photosynthetic plastids specialized in the synthesis and accumulation of carotenoids. During fruit ripening, chloroplasts differentiate into photosynthetically inactive chromoplasts in a process characterized by the degradation of the thylakoid membranes and the active synthesis and accumulation of carotenoids. This transition renders chromoplasts unable to photochemically synthesize ATP and ...
Mogi Taketo - - 2013
Using the voltage-multiplying circuits of chemolitho-autotrophic Fe-oxidizing bacteria (Mariprofundus ferrooxydans), we describe an integrated bioelectrochemical system that affords simultaneous CO(2) reduction and H(2)O oxidation at an external voltage of less than 1.24 V.
Chun Seung Min - - 2013
Cutaneous metastatic carcinoma of the nose is a rare presentation associated with lung cancer. We report here 3 cases of cutaneous metastatic carcinoma of the nose that originated from lung cancer. Two men, age 61 and 76 years, with lung cancers were referred for evaluation of a tumour on the ...
Cinta Pinzaru Simona - - 2013
An interdisciplinary approach employing functionalized nanoparticles and ultrasensitive spectroscopic techniques is reported here to track the molecular changes in early stage of malignancy. Melanoma tissue tracking at molecular level using both labelled and unlabelled silver and gold nanoparticles has been achieved using surface enhanced Raman scattering (SERS) technique. We used ...
Hattori Mitsuru - - 2013
We developed bioluminescence probes to detect quantitative interaction of GPCRs with arrestin isoforms β-arrestin1 and β-arrestin2 based on split luciferase complementation. Time-dependent GPCR-β-arrestin interactions showed two-types of remarkable variations that were consistent with a classification of GPCR classes. Positive charge residues in serine clusters located at the C-terminal region of ...
Yurt Lambrecht Fatma - - 2013
Abstract Bombesin and its derivatives exhibit a high affinity for gastrin-releasing peptide receptor (GRPr), which is over-expressed in a variety of human cancers (prostate, pancreatic, lung, etc.). The aim of this study was to investigate the in vitro potential of the hydrazinonicotinamide (HYNIC)-Q-Litorin. (99m)Tc labeling was performed by using different ...
Kallem Raja Reddy - - 2013
A highly sensitive and specific LC-ESI-MS/MS method has been developed and validated for simultaneous quantification of felodipine (FDP) and metoprolol (MPL) in rat plasma (50 μL) using phenacetin as an internal standard (IS) as per the FDA guidelines. Liquid-liquid extraction method was used to extract the analytes and IS from rat ...
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